Publikationen/Publications

1: Wu Y, Li C, Peng H, Swaidan A, Riehle A, Pollmeier B, Zhang Y, Gulbins E, Grassmé H. Acid sphingomyelinase contributes to the control of mycobacterial infection via a signaling cascade leading from reactive oxygen species to cathepsin D. Cells 2020;9(11):2406. https://doi.org/10.3390/cells9112406

2: Wu, Y.; Liu, Y.; Gulbins, E.; Grassmé, H. The Anti-Infectious Role of Sphingosine in Microbial Diseases. Cells 2021, 10, 1105. https://doi.org/10.3390/cells10051105

3: Li C, Wang A, Wu Y, Gulbins E, Grassmé H, Zhao Z. Acid Sphingomyelinase-Ceramide System in Bacterial Infections. Cell Physiol Biochem. 2019;52(2):280-301. doi: 10.33594/000000021. Epub 2019 Feb 28. Review. PubMed PMID: 30816675.

4: Wu Y, Li C, Riehle A, Pollmeier B, Gulbins E, Grassmé H. Mycobacterial Infection is Promoted by Neutral Sphingomyelinase 2 Regulating a Signaling Cascade Leading to Activation of β1-Integrin. Cell Physiol Biochem. 2018;51(4):1815-1829. doi: 10.1159/000495683. Epub 2018 Nov 30. PubMed PMID: 30504725.

5: Wu Y, Gulbins E, Grassmé H. The function of sphingomyelinases in mycobacterial infections. Biol Chem. 2018 Sep 25;399(10):1125-1133. doi: 10.1515/hsz-2018-0179. Review. PubMed PMID: 29924725.

6: Becker KA, Riethmüller J, Seitz AP, Gardner A, Boudreau R, Kamler M, Kleuser B, Schuchman E, Caldwell CC, Edwards MJ, Grassmé H, Brodlie M, Gulbins E. Sphingolipids as targets for inhalation treatment of cystic fibrosis. Adv Drug Deliv Rev. 2018 Aug;133:66-75. doi: 10.1016/j.addr.2018.04.015. Epub 2018 Apr 24. Review. PubMed PMID: 29698625.

7: Becker KA, Fahsel B, Kemper H, Mayeres J, Li C, Wilker B, Keitsch S, Soddemann M, Sehl C, Kohnen M, Edwards MJ, Grassmé H, Caldwell CC, Seitz A, Fraunholz M, Gulbins E. Staphylococcus aureus Alpha-Toxin Disrupts Endothelial-Cell Tight Junctions via Acid Sphingomyelinase and Ceramide. Infect Immun. 2017 Dec 19;86(1). pii: e00606-17. doi: 10.1128/IAI.00606-17. Print 2018 Jan. PubMed PMID: 29084896; PubMed Central PMCID: PMC5736828.

8: Li C, Wu Y, Riehle A, Orian-Rousseau V, Zhang Y, Gulbins E, Grassmé H. Regulation of Staphylococcus aureus Infection of Macrophages by CD44, Reactive Oxygen Species, and Acid Sphingomyelinase. Antioxid Redox Signal. 2017 Aug 29. doi: 10.1089/ars.2017.6994. [Epub ahead of print] PubMed PMID: 28747072.

9: Grassmé H, Henry B, Ziobro R, Becker KA, Riethmüller J, Gardner A, Seitz AP, Steinmann J, Lang S, Ward C, Schuchman EH, Caldwell CC, Kamler M, Edwards MJ, Brodlie M, Gulbins E. β1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingosine, Promoting Bacterial Infections. Cell Host Microbe. 2017 Jun 14;21(6):707-718.e8. doi: 10.1016/j.chom.2017.05.001. Epub 2017 May 25. PubMed PMID: 28552668; PubMed Central PMCID: PMC5475347.

10: Li C, Wu Y, Riehle A, Ma J, Kamler M, Gulbins E, Grassmé H. Staphylococcus aureus Survives in Cystic Fibrosis Macrophages, Forming a Reservoir for Chronic Pneumonia. Infect Immun. 2017 Apr 21;85(5). pii: e00883-16. doi: 10.1128/IAI.00883-16. Print 2017 May. PubMed PMID: 28289144; PubMed Central PMCID: PMC5400852.

11: Wu Y, Gulbins E, Grassmé H. Crosstalk Between Sphingomyelinases and Reactive Oxygen Species in Mycobacterial Infection. Antioxid Redox Signal. 2017 Apr 6. doi: 10.1089/ars.2017.7050. [Epub ahead of print] PubMed PMID: 28276697.

12: Gulbins A, Grassmé H, Hoehn R, Kohnen M, Edwards MJ, Kornhuber J, Gulbins E. Role of Janus-Kinases in Major Depressive Disorder. Neurosignals. 2016;24(1):71-80. doi: 10.1159/000442613. Epub 2016 Aug 3. PubMed PMID: 27487096.

13: Gulbins A, Grassmé H, Hoehn R, Wilker B, Soddemann M, Kohnen M, Edwards MJ, Kornhuber J, Gulbins E. Regulation of Neuronal Stem Cell Proliferation in the Hippocampus by Endothelial Ceramide. Cell Physiol Biochem. 2016;39(2):790-801. doi: 10.1159/000447789. Epub 2016 Aug 1. PubMed PMID: 27475812.

14: Hoehn R, Monse M, Pohl E, Wranik S, Wilker B, Keitsch S, Soddemann M, Kornhuber J, Kohnen M, Edwards MJ, Grassmé H, Gulbins E. Melatonin Acts as an Antidepressant by Inhibition of the Acid Sphingomyelinase/Ceramide System. Neurosignals. 2016;24(1):48-58. doi: 10.1159/000442611. Epub 2016 Jul 11. PubMed PMID: 27398923.

15: Tavakoli Tabazavareh S, Seitz A, Jernigan P, Sehl C, Keitsch S, Lang S, Kahl BC, Edwards M, Grassmé H, Gulbins E, Becker KA. Lack of Sphingosine Causes Susceptibility to Pulmonary Staphylococcus Aureus Infections in Cystic Fibrosis. Cell Physiol Biochem. 2016;38(6):2094-102. doi: 10.1159/000445567. Epub 2016 May 17. PubMed PMID: 27184795.

16: Li C, Peng H, Japtok L, Seitz A, Riehle A, Wilker B, Soddemann M, Kleuser B, Edwards M, Lammas D, Zhang Y, Gulbins E, Grassme H. Inhibition of neutral sphingomyelinase protects mice against systemic tuberculosis. Front Biosci (Elite Ed). 2016 Jan 1;8:311-25. PubMed PMID: 26709664.

17: Jernigan PL, Hoehn RS, Grassmé H, Edwards MJ, Müller CP, Kornhuber J, Gulbins E. Sphingolipids in Major Depression. Neurosignals. 2015;23(1):49-58. doi: 10.1159/000442603. Epub 2015 Dec 19. Review. PubMed PMID: 26684792.

18: Grassmé H, Jernigan PL, Hoehn RS, Wilker B, Soddemann M, Edwards MJ, Müller CP, Kornhuber J, Gulbins E. Inhibition of Acid Sphingomyelinase by Antidepressants Counteracts Stress-Induced Activation of P38-Kinase in Major Depression. Neurosignals. 2015;23(1):84-92. doi: 10.1159/000442606. Epub 2015 Dec 19. PubMed PMID: 26682751.

19: Carpinteiro A, Becker KA, Japtok L, Hessler G, Keitsch S, Požgajovà M, Schmid KW, Adams C, Müller S, Kleuser B, Edwards MJ, Grassmé H, Helfrich I, Gulbins E. Regulation of hematogenous tumor metastasis by acid sphingomyelinase. EMBO Mol Med. 2015 Jun;7(6):714-34. doi: 10.15252/emmm.201404571. PubMed PMID: 25851537; PubMed Central PMCID: PMC4459814.

20: Seitz AP, Grassmé H, Edwards MJ, Pewzner-Jung Y, Gulbins E. Ceramide and sphingosine in pulmonary infections. Biol Chem. 2015 Jun;396(6-7):611-20. doi: 10.1515/hsz-2014-0285. PubMed PMID: 25720061.

21: Managò A, Becker KA, Carpinteiro A, Wilker B, Soddemann M, Seitz AP, Edwards MJ, Grassmé H, Szabò I, Gulbins E. Pseudomonas aeruginosa pyocyanin induces neutrophil death via mitochondrial reactive oxygen species and mitochondrial acid sphingomyelinase. Antioxid Redox Signal. 2015 May 1;22(13):1097-110. doi: 10.1089/ars.2014.5979. Epub 2015 Mar 18. PubMed PMID: 25686490; PubMed Central PMCID: PMC4403017.

22: Peng H, Li C, Kadow S, Henry BD, Steinmann J, Becker KA, Riehle A, Beckmann N, Wilker B, Li PL, Pritts T, Edwards MJ, Zhang Y, Gulbins E, Grassmé H. Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis. J Mol Med (Berl). 2015 Jun;93(6):675-89. doi: 10.1007/s00109-014-1246-y. Epub 2015 Jan 25. PubMed PMID: 25616357; PubMed Central PMCID: PMC4432103.