21.08.2022 - 11:05:48

Novel Web Tool PPI-Affinity

A new paper is out, published in the Journal of Proteome Research with a cover image featured in the current issue. It introduces PPI-Affinity, a web tool developed by scientists of the groups of Elsa Sánchez García and Michael Ehrmann. The web server scores protein–protein and protein–peptide complexes based on their predicted binding affinity and also optimizes the affinity of a complex by mutating and screening selected residues. PPI-Affinity can be employed at early steps of drug design processes and thus support the design of new therapeutics significantly. PPI-Affinity is freely accessible at https://protdcal.zmb.uni-due.de/PPIAffinity.