17.06.2023 - 13:34:04

Innovative Catalyst-Free Method for Oxazolidinone Synthesis

In the newest volume of the European Journal of Organic Chemistry Journal, there is a new paper by Markus Kaiser (B01) and his group.This work introduces a catalyst-free, multicomponent method for oxazolidinone synthesis. By ingeniously combining primary aliphatic/aromatic amines with dibromoethane and using cesium carbonate/hydrogencarbonate as base and C1 source, the study enables streamlined late-stage functionalization of amino groups into N-substituted oxazolidinones. Notably, the versatility of this approach shines through in the synthesis of an oxazolidinone-modified dipeptidyl peptidase 8 (DPP8) inhibitor, showcasing its potential in medicinal chemistry.