20.07.2023 - 12:36:24

Cell-Based Assays for PROTAC

There is a new paper published in Cell Chemical Biology, featuring the cover. Martin Schwalm from the Knapp lab (B03) and his colleagues have developed a cell-based assays to measure PROTAC (PROteolysis TArgeting Chimeras) -induced degradation and ternary complex formation kinetics and stability in cells. These assays offer a strategy for the rational optimization of PROTACs in early degradation cascades.