01.08.2023 - 10:37:15

A Link Between Melanoma Resistance and HLA-II Antigen Presentation

The latest paper by Annette Paschen (A13) and her group was recently published in the Journal of Clinical Cancer Research. Their research establishes a connection between melanoma resistance and CD4 T cells, IFN?, and ICB, all at the HLA-II level. This underscores the importance of tumor cell-intrinsic HLA-II antigen presentation in controlling the disease and emphasizes the need for strategies to counteract its downregulation, aiming for better patient outcomes.