Publikationen/Publications

Selected publications

1. Carpinteiro A, Edwards MJ, Hoffmann M, Kochs G, Gripp B, Weigang S, Adams C, Carpinteiro E, Gulbins A, Keitsch S, Sehl C, Soddemann M, Wilker B, Kamler M, Bertsch T, Lang KS, Patel S, Wilson GC, Walter S, Hengel H, Pöhlmann S, Lang PA, Kornhuber J, Becker KA, Ahmad SA, Fassbender K, Gulbins E. Pharmacological inhibition of acid sphingomyelinase prevents uptake of SARS-CoV-2 by epithelial cells. CELL Rep Med 2020;1:100142.
    
2. Verhaegh R, Becker KA, Edwards MJ, Gulbins E. Sphingosine kills bacteria by binding to cardiolipin. J Biol Chem 2020;295:7686-96.
    
3. Gardner AI, Haq IJ, Simpson AJ, Becker KA, Gallagher J, Saint-Criq V, Verdon B, Mavin E, Trigg A, Gray MA, Koulman A, McDonnell MJ, Fisher AJ, Kramer EL, Clancy JP, Ward C, Schuchman EH, Gulbins E, Brodlie M. Recombinant acid ceramidase reduces inflammation and infection in cystic fibrosis. Am J Respir Crit Care Med 2020;202:1133-1145.
4. Lang J, Bohn P, Bhat H, Jastrow H, Walkenfort B, Cansiz F, Fink J, Bauer M, Olszewski D, Ramos-Nascimento A, Duhan V, Friedrich SK, Becker KA, Krawczyk A, Edwards MJ, Burchert A, Huber M, Friebus-Kardash J, Göthert JR, Hardt C, Probst HC, Schumacher F, Köhrer K, Kleuser B, Babiychuk EB, Sodeik B, Seibel J, Greber UF, Lang PA*, Gulbins E*, Lang KS*. Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease. Nat Commun 2020;11:1338. (*shared)
    
5. Gulbins A, Schumacher F, Becker KA, Wilker B, Soddemann M, Boldrin F, Müller CP, Edwards MJ, Goodman M, Caldwell CC, Kleuser B, Kornhuber J, Szabo I, Gulbins E. Antidepressants act by inducing autophagy controlled by sphingomyelin-ceramide. Mol Psychiatry 2018;23:2324-46.
    
6. Grassmé H, Henry B, Ziobro R, Becker KA, Riethmüller J, Gardner A, Seitz AP, Steinmann J, Lang S, Ward C, Schuchman EH, Caldwell CC, Kamler M, Edwards MJ, Brodlie M, Gulbins E. β1-Integrin accumulates in cystic fibrosis luminal airway epithelial membranes and decreases sphingosine, promoting bacterial infections. Cell Host Microbe 2017;21:707-718.
    
7. Nojima H, Freeman CM, Schuster RM, Japtok L, Kleuser B, Edwards MJ, Gulbins E, Lentsch AB. Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate. J Hepatol 2016;64:60-8.
    
8. Henry BD*, Neill DR*, Becker KA*, Gore S, Bricio-Moreno L, Ziobro R, Edwards MJ, Mühlemann K, Steinmann J, Kleuser B, Japtok L, Luginbühl M, Wolfmeier H, Scherag A, Gulbins E*, Kadioglu A*, Draeger A*, Babiychuk EB*. Engineered liposomes sequester bacterial exotoxins and protect from severe invasive bacterial infections in mice. Nat Biotechnol 2015;33:81-8. (*shared first authorship and senior authorship).
    
9. Carpinteiro A, Becker KA, Japtok L, Hessler G, Keitsch S, Pozgajova M, Schmid KW, Adams C, Müller S, Kleuser B, Edwards MJ, Grassmé H, Helfrich I, Gulbins E. Regulation of hematogenous tumor metastasis by acid sphingomyelinase. EMBO Mol Med 2015;7:714-34.
    
10. Pewzner-Jung Y, Tavakoli Tabazavareh S, Grassmé H, Becker KA, Japtok L, Steinmann J, Joseph T, Lang S, Tuemmler B, Schuchman EH, Lentsch AB, Kleuser B, Edwards MJ, Futerman AH, Gulbins E. Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa. EMBO Mol Med 2014;6:1205-14.
     
11. Gulbins E, Palmada M, Reichel M, Lüth A, Böhmer C, Amato D, Müller CP, Tischbirek CH, Groemer TW, Tabatabai G, Becker KA, Tripal P, Staedtler S, Ackermann TF, v. Brederode J, Alzheimer C, Weller M, Lang UE, Kleuser B, Grassmé H, Kornhuber J. Acid sphingomyelinase/ceramide system mediates effects of antidepressant drugs. Nat Med 2013;19:934-8.
     
12. Leanza L, Henry B, Sassi N, Zoratti M, Chandy KG, Gulbins E, Szabò I. Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells. EMBO Mol Med 2012;4:577-93.
     
13. Zhang Y, Li X, Carpinteiro A, Goettel JA, Soddemann M, Gulbins E. Kinase suppressor of Ras-1 protects against pulmonary Pseudomonas aeruginosa infections. Nat Med 2011;17:341-6.
     
14. Szabo I, Bock J, Grassmé H, Soddemann M, Wilker B, Lang F, Zoratti M, Gulbins E. Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes. Proc Natl Acad Sci U S A 2008;105:14861-6.
     
15. Teichgräber V, Ulrich M, Endlich N, Riethmüller J, Wilker B, De Oliveira-Munding CC, van Heeckeren AM, Barr ML, von Kürthy G, Schmid KW, Weller M, Tümmler B, Lang F, Grassmé H, Döring G, Gulbins E. Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis. Nat Med 2008;14:382-91.
     
16. Lang PA, Schenck M, Nicolay JP, Becker JU, Kempe DS, Lupescu A, Koka S, Eisele K, Klarl BA, Rübben H, Schmid KW, Mann K, Hildenbrand S, Hefter H, Huber SM, Wieder T, Erhardt A, Häussinger D, Gulbins E*, Lang F*. Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide. Nat Med 2007;13:164-70. (*shared corresponding authorship).
     
17. Szabo I, Bock J, Jekle A, Soddemann M, Adams C, Lang F, Zoratti M, Gulbins E. A novel potassium channel in lymphocyte mitochondria. J Biol Chem 2005;280:12790-8.
     
18. Grassmé H, Jendrossek V, Riehle A, von Kürthy G, Berger J, Schwarz H, Weller M, Kolesnick R, Gulbins E. Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts. Nat Med 2003;9:322-30.
     
19. Grassmé H, Kirschnek S, Riethmueller J, Riehle A, von Kürthy G, Lang F, Weller M, Gulbins E. CD95/CD95 ligand interactions on epithelial cells in host defense to Pseudomonas aeruginosa. Science 2000;290:527-30.
     
20. Grassmé H, Jekle A, Riehle A, Schwarz H, Berger J, Sandhoff K, Kolesnick R, Gulbins E. CD95 signaling via ceramide-rich membrane rafts. J Biol Chem 2001;276:20589-96.
     
21. *Grassmé H, *Gulbins E, Brenner B, Ferlinz K, Sandhoff K, Harzer K, Lang F, Meyer TF. Acidic sphingomyelinase mediates entry of N. gonorrhoeae into nonphagocytic cells. Cell 1997;91:605-15. (*shared first authorship).

 

Other publications

1: Kalinichenko LS, Hammad L, Reichel M, Kohl Z, Gulbins E, Kornhuber J, Müller CP. Acid sphingomyelinase controls dopamine activity and responses to appetitive stimuli in mice. Brain Res Bull. 2019 Mar;146:310-319. doi: 10.1016/j.brainresbull.2019.01.026. Epub 2019 Feb 1. PubMed PMID: 30716394.

2: Gulbins A, Schumacher F, Becker KA, Wilker B, Soddemann M, Boldrin F, Müller CP, Edwards MJ, Goodman M, Caldwell CC, Kleuser B, Kornhuber J, Szabo I, Gulbins E. Antidepressants regulate autophagy by targeting acid sphingomyelinase. Mol Psychiatry. 2018 Dec;23(12):2251. doi: 10.1038/s41380-018-0319-7. PubMed PMID: 30552418.

3: Mühle C, Weinland C, Gulbins E, Lenz B, Kornhuber J. Peripheral Acid Sphingomyelinase Activity Is Associated with Biomarkers and Phenotypes of Alcohol Use and Dependence in Patients and Healthy Controls. Int J Mol Sci. 2018 Dec 13;19(12). pii: E4028. doi: 10.3390/ijms19124028. PubMed PMID: 30551571; PubMed Central PMCID: PMC6320816.

4: Wu Y, Li C, Riehle A, Pollmeier B, Gulbins E, Grassmé H. Mycobacterial Infection is Promoted by Neutral Sphingomyelinase 2 Regulating a Signaling Cascade Leading to Activation of β1-Integrin. Cell Physiol Biochem. 2018;51(4):1815-1829. doi: 10.1159/000495683. Epub 2018 Nov 30. PubMed PMID: 30504725.

5: Bodas M, Pehote G, Silverberg D, Gulbins E, Vij N. Autophagy augmentation alleviates cigarette smoke-induced CFTR-dysfunction, ceramide-accumulation and COPD-emphysema pathogenesis. Free Radic Biol Med. 2019 Feb 1;131:81-97. doi: 10.1016/j.freeradbiomed.2018.11.023. Epub 2018 Nov 28. PubMed PMID: 30500419.

6: Park MH, Lee JY, Park KH, Jung IK, Kim KT, Lee YS, Ryu HH, Jeong Y, Kang M, Schwaninger M, Gulbins E, Reichel M, Kornhuber J, Yamaguchi T, Kim HJ, Kim SH, Schuchman EH, Jin HK, Bae JS. Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM. Neuron. 2018 Nov 7;100(3):762. doi: 10.1016/j.neuron.2018.10.038. PubMed PMID: 30408445.

7: Reichel M, Rhein C, Hofmann LM, Monti J, Japtok L, Langgartner D, Füchsl AM, Kleuser B, Gulbins E, Hellerbrand C, Reber SO, Kornhuber J. Chronic Psychosocial Stress in Mice Is Associated With Increased Acid Sphingomyelinase Activity in Liver and Serum and With Hepatic C16:0-Ceramide Accumulation. Front Psychiatry. 2018 Oct 16;9:496. doi: 10.3389/fpsyt.2018.00496. eCollection 2018. PubMed PMID: 30386262; PubMed Central PMCID: PMC6198178.

8: Baker JE, Boudreau RM, Seitz AP, Caldwell CC, Gulbins E, Edwards MJ. Sphingolipids and Innate Immunity: A New Approach to Infection in the Post-Antibiotic Era? Surg Infect (Larchmt). 2018 Oct 2. doi: 10.1089/sur.2018.187. [Epub ahead of print] PubMed PMID: 30277846.

9: Park MH, Lee JY, Park KH, Jung IK, Kim KT, Lee YS, Ryu HH, Jeong Y, Kang M, Schwaninger M, Gulbins E, Reichel M, Kornhuber J, Yamaguchi T, Kim HJ, Kim SH, Schuchman EH, Jin HK, Bae JS. Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM. Neuron. 2018 Oct 10;100(1):167-182.e9. doi: 10.1016/j.neuron.2018.09.010. Epub 2018 Sep 27. Erratum in: Neuron. 2018 Nov 7;100(3):762. PubMed PMID: 30269989.

10: Rhein C, Löber S, Gmeiner P, Gulbins E, Tripal P, Kornhuber J. Derivatization of common antidepressant drugs increases inhibition of acid sphingomyelinase and reduces induction of phospholipidosis. J Neural Transm (Vienna). 2018 Dec;125(12):1837-1845. doi: 10.1007/s00702-018-1923-z. Epub 2018 Sep 6. PubMed PMID: 30191367.

11: Carpinteiro A, Becker KA, Gulbins E. Highlight: sphingolipids in infectious biology and immunology. Biol Chem. 2018 Sep 25;399(10):1113. doi: 10.1515/hsz-2018-0341. PubMed PMID: 30138109.

12: Gulbins A, Schumacher F, Becker KA, Wilker B, Soddemann M, Boldrin F, Müller CP, Edwards MJ, Goodman M, Caldwell CC, Kleuser B, Kornhuber J, Szabo I, Gulbins E. Antidepressants act by inducing autophagy controlled by sphingomyelin-ceramide. Mol Psychiatry. 2018 Dec;23(12):2324-2346. doi: 10.1038/s41380-018-0090-9. Epub 2018 Jul 23. PubMed PMID: 30038230; PubMed Central PMCID: PMC6294742.

13: Bezgovsek J, Gulbins E, Friedrich SK, Lang KS, Duhan V. Sphingolipids in early viral replication and innate immune activation. Biol Chem. 2018 Sep 25;399(10):1115-1123. doi: 10.1515/hsz-2018-0181. PubMed PMID: 29975662.

14: Wu Y, Gulbins E, Grassmé H. The function of sphingomyelinases in mycobacterial infections. Biol Chem. 2018 Sep 25;399(10):1125-1133. doi: 10.1515/hsz-2018-0179. Review. PubMed PMID: 29924725.

15: Beckmann N, Kadow S, Schumacher F, Göthert JR, Kesper S, Draeger A, Schulz-Schaeffer WJ, Wang J, Becker JU, Kramer M, Kühn C, Kleuser B, Becker KA, Gulbins E, Carpinteiro A. Pathological manifestations of Farber disease in a new mouse model. Biol Chem. 2018 Sep 25;399(10):1183-1202. doi: 10.1515/hsz-2018-0170. PubMed PMID: 29908121.

16: Becker KA, Riethmüller J, Seitz AP, Gardner A, Boudreau R, Kamler M, Kleuser B, Schuchman E, Caldwell CC, Edwards MJ, Grassmé H, Brodlie M, Gulbins E. Sphingolipids as targets for inhalation treatment of cystic fibrosis. Adv Drug Deliv Rev. 2018 Aug;133:66-75. doi: 10.1016/j.addr.2018.04.015. Epub 2018 Apr 24. Review. PubMed PMID: 29698625.

17: Keitsch S, Riethmüller J, Soddemann M, Sehl C, Wilker B, Edwards MJ, Caldwell CC, Fraunholz M, Gulbins E, Becker KA. Pulmonary infection of cystic fibrosis mice with Staphylococcus aureus requires expression of α-toxin. Biol Chem. 2018 Sep 25;399(10):1203-1213. doi: 10.1515/hsz-2018-0161. PubMed PMID: 29613852.

18: Xia BT, Beckmann N, Winer LK, Kim Y, Goetzman HS, Veile RE, Gulbins E, Goodman MD, Nomellini V, Caldwell CC. Amitriptyline Treatment Mitigates Sepsis-Induced Tumor Necrosis Factor Expression and Coagulopathy. Shock. 2019 Mar;51(3):356-363. doi: 10.1097/SHK.0000000000001146. PubMed PMID: 29608550.

19: Kim Y, Abplanalp WA, Jung AD, Schuster RM, Lentsch AB, Gulbins E, Caldwell CC, Pritts TA. Endocytosis of Red Blood Cell Microparticles by Pulmonary Endothelial Cells is Mediated By Rab5. Shock. 2018 Mar;49(3):288-294. doi: 10.1097/SHK.0000000000000995. PubMed PMID: 29438268; PubMed Central PMCID: PMC5813702.

20: Kalinichenko LS, Gulbins E, Kornhuber J, Müller CP. The role of sphingolipids in psychoactive drug use and addiction. J Neural Transm (Vienna). 2018 Apr;125(4):651-672. doi: 10.1007/s00702-018-1840-1. Epub 2018 Jan 10. Review. PubMed PMID: 29322265.

21: Li PL, Gulbins E. Bioactive Lipids and Redox Signaling: Molecular Mechanism and Disease Pathogenesis. Antioxid Redox Signal. 2018 Jan 24. doi: 10.1089/ars.2017.7467. [Epub ahead of print] PubMed PMID: 29237272; PubMed Central PMCID: PMC5849277.

22: Becker KA, Halmer R, Davies L, Henry BD, Ziobro-Henry R, Decker Y, Liu Y, Gulbins E, Fassbender K, Walter S. Blockade of Experimental Multiple Sclerosis by Inhibition of the Acid Sphingomyelinase/Ceramide System. Neurosignals. 2017;25(1):88-97. doi: 10.1159/000484621. Epub 2017 Nov 6. PubMed PMID: 29131010.

23: Becker KA, Fahsel B, Kemper H, Mayeres J, Li C, Wilker B, Keitsch S, Soddemann M, Sehl C, Kohnen M, Edwards MJ, Grassmé H, Caldwell CC, Seitz A, Fraunholz M, Gulbins E. Staphylococcus aureus Alpha-Toxin Disrupts Endothelial-Cell Tight Junctions via Acid Sphingomyelinase and Ceramide. Infect Immun. 2017 Dec 19;86(1). pii: e00606-17. doi: 10.1128/IAI.00606-17. Print 2018 Jan. PubMed PMID: 29084896; PubMed Central PMCID: PMC5736828.

24: Rice TC, Pugh AM, Seitz AP, Gulbins E, Nomellini V, Caldwell CC. Sphingosine rescues aged mice from pulmonary pseudomonas infection. J Surg Res. 2017 Nov;219:354-359. doi: 10.1016/j.jss.2017.06.042. Epub 2017 Jul 25. PubMed PMID: 29078905; PubMed Central PMCID: PMC5663241.

25: Ma J, Gulbins E, Edwards MJ, Caldwell CC, Fraunholz M, Becker KA. Staphylococcus aureus α-Toxin Induces Inflammatory Cytokines via Lysosomal Acid Sphingomyelinase and Ceramides. Cell Physiol Biochem. 2017;43(6):2170-2184. doi: 10.1159/000484296. Epub 2017 Oct 25. PubMed PMID: 29069651.

26: Becker KA, Li X, Seitz A, Steinmann J, Koch A, Schuchman E, Kamler M, Edwards MJ, Caldwell CC, Gulbins E. Neutrophils Kill Reactive Oxygen Species-Resistant Pseudomonas aeruginosa by Sphingosine. Cell Physiol Biochem. 2017;43(4):1603-1616. doi: 10.1159/000482024. Epub 2017 Oct 17. PubMed PMID: 29040968.

27: Beckmann N, Becker KA, Walter S, Becker JU, Kramer M, Hessler G, Weber S, Göthert JR, Fassbender K, Gulbins E, Carpinteiro A. Regulation of Arthritis Severity by the Acid Sphingomyelinase. Cell Physiol Biochem. 2017;43(4):1460-1471. doi: 10.1159/000481968. Epub 2017 Oct 16. PubMed PMID: 29035882.

28: Fayyaz S, Japtok L, Schumacher F, Wigger D, Schulz TJ, Haubold K, Gulbins E, Völler H, Kleuser B. Lysophosphatidic Acid Inhibits Insulin Signaling in Primary Rat Hepatocytes via the LPA3 Receptor Subtype and is Increased in Obesity. Cell Physiol Biochem. 2017;43(2):445-456. doi: 10.1159/000480470. Epub 2017 Sep 1. PubMed PMID: 28922661.

29: Item F, Wueest S, Lemos V, Stein S, Lucchini FC, Denzler R, Fisser MC, Challa TD, Pirinen E, Kim Y, Hemmi S, Gulbins E, Gross A, O'Reilly LA, Stoffel M, Auwerx J, Konrad D. Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function. Nat Commun. 2017 Sep 7;8(1):480. doi: 10.1038/s41467-017-00566-9. PubMed PMID: 28883393; PubMed Central PMCID: PMC5589858.

30: Venturini E, Leanza L, Azzolini M, Kadow S, Mattarei A, Weller M, Tabatabai G, Edwards MJ, Zoratti M, Paradisi C, Szabò I, Gulbins E, Becker KA. Targeting the Potassium Channel Kv1.3 Kills Glioblastoma Cells. Neurosignals. 2017;25(1):26-38. doi: 10.1159/000480643. Epub 2017 Sep 1. PubMed PMID: 28869943.

31: Li C, Wu Y, Riehle A, Orian-Rousseau V, Zhang Y, Gulbins E, Grassmé H. Regulation of Staphylococcus aureus Infection of Macrophages by CD44, Reactive Oxygen Species, and Acid Sphingomyelinase. Antioxid Redox Signal. 2017 Aug 29. doi: 10.1089/ars.2017.6994. [Epub ahead of print] PubMed PMID: 28747072.

32: Rice TC, Pugh AM, Xia BT, Seitz AP, Whitacre BE, Gulbins E, Caldwell CC. Bronchoalveolar Lavage Microvesicles Protect Burn-Injured Mice from Pulmonary Infection. J Am Coll Surg. 2017 Oct;225(4):538-547. doi: 10.1016/j.jamcollsurg.2017.06.010. Epub 2017 Jul 6. PubMed PMID: 28690205; PubMed Central PMCID: PMC5614837.

33: Schumacher F, Neuber C, Finke H, Nieschalke K, Baesler J, Gulbins E, Kleuser B. The sphingosine 1-phosphate breakdown product, (2E)-hexadecenal, forms protein adducts and glutathione conjugates in vitro. J Lipid Res. 2017 Aug;58(8):1648-1660. doi: 10.1194/jlr.M076562. Epub 2017 Jun 6. PubMed PMID: 28588048; PubMed Central PMCID: PMC5538286.

34: Chami M, Halmer R, Schnoeder L, Anne Becker K, Meier C, Fassbender K, Gulbins E, Walter S. Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelination. PLoS One. 2017 Jun 5;12(6):e0178622. doi: 10.1371/journal.pone.0178622. eCollection 2017. PubMed PMID: 28582448; PubMed Central PMCID: PMC5459450.

35: Grassmé H, Henry B, Ziobro R, Becker KA, Riethmüller J, Gardner A, Seitz AP, Steinmann J, Lang S, Ward C, Schuchman EH, Caldwell CC, Kamler M, Edwards MJ, Brodlie M, Gulbins E. β1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingosine, Promoting Bacterial Infections. Cell Host Microbe. 2017 Jun 14;21(6):707-718.e8. doi: 10.1016/j.chom.2017.05.001. Epub 2017 May 25. PubMed PMID: 28552668; PubMed Central PMCID: PMC5475347.

36: Sydor S, Sowa JP, Megger DA, Schlattjan M, Jafoui S, Wingerter L, Carpinteiro A, Baba HA, Bechmann LP, Sitek B, Gerken G, Gulbins E, Canbay A. Acid sphingomyelinase deficiency in Western diet-fed mice protects against adipocyte hypertrophy and diet-induced liver steatosis. Mol Metab. 2017 Mar 12;6(5):416-427. doi: 10.1016/j.molmet.2017.03.002. eCollection 2017 May. PubMed PMID: 28462076; PubMed Central PMCID: PMC5404101.

37: Kovacic B, Sehl C, Wilker B, Kamler M, Gulbins E, Becker KA. Glucosylceramide Critically Contributes to the Host Defense of Cystic Fibrosis Lungs. Cell Physiol Biochem. 2017;41(3):1208-1218. doi: 10.1159/000464382. Epub 2017 Mar 6. PubMed PMID: 28427052.

38: Leanza L, Romio M, Becker KA, Azzolini M, Trentin L, Managò A, Venturini E, Zaccagnino A, Mattarei A, Carraretto L, Urbani A, Kadow S, Biasutto L, Martini V, Severin F, Peruzzo R, Trimarco V, Egberts JH, Hauser C, Visentin A, Semenzato G, Kalthoff H, Zoratti M, Gulbins E, Paradisi C, Szabo I. Direct Pharmacological Targeting of a Mitochondrial Ion Channel Selectively Kills Tumor Cells In Vivo. Cancer Cell. 2017 Apr 10;31(4):516-531.e10. doi: 10.1016/j.ccell.2017.03.003. PubMed PMID: 28399409.

39: Martin GE, Boudreau RM, Couch C, Becker KA, Edwards MJ, Caldwell CC, Gulbins E, Seitz A. Sphingosine's role in epithelial host defense: A natural antimicrobial and novel therapeutic. Biochimie. 2017 Oct;141:91-96. doi: 10.1016/j.biochi.2017.03.014. Epub 2017 Mar 21. PubMed PMID: 28341550.

40: Li C, Wu Y, Riehle A, Ma J, Kamler M, Gulbins E, Grassmé H. Staphylococcus aureus Survives in Cystic Fibrosis Macrophages, Forming a Reservoir for Chronic Pneumonia. Infect Immun. 2017 Apr 21;85(5). pii: e00883-16. doi: 10.1128/IAI.00883-16. Print 2017 May. PubMed PMID: 28289144; PubMed Central PMCID: PMC5400852.

41: Wu Y, Gulbins E, Grassmé H. Crosstalk Between Sphingomyelinases and Reactive Oxygen Species in Mycobacterial Infection. Antioxid Redox Signal. 2017 Apr 6. doi: 10.1089/ars.2017.7050. [Epub ahead of print] PubMed PMID: 28276697.

42: Bao J, Li G, Yuan X, Li PL, Gulbins E. Contribution of p62 to Phenotype Transition of Coronary Arterial Myocytes with Defective Autophagy. Cell Physiol Biochem. 2017;41(2):555-568. doi: 10.1159/000457877. Epub 2017 Feb 3. PubMed PMID: 28214847.

43: Rice TC, Armocida SM, Kuethe JW, Midura EF, Jain A, Hildeman DA, Healy DP, Gulbins E, Caldwell CC. Burn injury influences the T cell homeostasis in a butyrate-acid sphingomyelinase dependent manner. Cell Immunol. 2017 Mar;313:25-31. doi: 10.1016/j.cellimm.2016.12.004. Epub 2016 Dec 26. PubMed PMID: 28063598; PubMed Central PMCID: PMC5559081.

44: Hoehn RS, Jernigan PL, Japtok L, Chang AL, Midura EF, Caldwell CC, Kleuser B, Lentsch AB, Edwards MJ, Gulbins E, Pritts TA. Acid Sphingomyelinase Inhibition in Stored Erythrocytes Reduces Transfusion-Associated Lung Inflammation. Ann Surg. 2017 Jan;265(1):218-226. doi: 10.1097/SLA.0000000000001648. PubMed PMID: 28009749.

45: Müller CP, Kalinichenko LS, Tiesel J, Witt M, Stöckl T, Sprenger E, Fuchser J, Beckmann J, Praetner M, Huber SE, Amato D, Mühle C, Büttner C, Ekici AB, Smaga I, Pomierny-Chamiolo L, Pomierny B, Filip M, Eulenburg V, Gulbins E, Lourdusamy A, Reichel M, Kornhuber J. Paradoxical antidepressant effects of alcohol are related to acid sphingomyelinase and its control of sphingolipid homeostasis. Acta Neuropathol. 2017 Mar;133(3):463-483. doi: 10.1007/s00401-016-1658-6. Epub 2016 Dec 20. PubMed PMID: 28000031; PubMed Central PMCID: PMC5325869.

46: Rhein C, Reichel M, Kramer M, Rotter A, Lenz B, Mühle C, Gulbins E, Kornhuber J. Alternative splicing of SMPD1 coding for acid sphingomyelinase in major depression. J Affect Disord. 2017 Feb;209:10-15. doi: 10.1016/j.jad.2016.09.019. Epub 2016 Sep 28. PubMed PMID: 27866044.

47: Bao JX, Zhang QF, Wang M, Xia M, Boini KM, Gulbins E, Zhang Y, Li PL. Implication of CD38 gene in autophagic degradation of collagen I in mouse coronary arterial myocytes. Front Biosci (Landmark Ed). 2017 Jan 1;22:558-569. PubMed PMID: 27814632; PubMed Central PMCID: PMC5509348.

48: Johnson BL 3rd, Rice TC, Xia BT, Boone KI, Green EA, Gulbins E, Caldwell CC. Amitriptyline Usage Exacerbates the Immune Suppression Following Burn Injury. Shock. 2016 Nov;46(5):541-548. PubMed PMID: 27172154; PubMed Central PMCID: PMC5103308.

49: Becker KA, Beckmann N, Adams C, Hessler G, Kramer M, Gulbins E, Carpinteiro A. Melanoma cell metastasis via P-selectin-mediated activation of acid sphingomyelinase in platelets. Clin Exp Metastasis. 2017 Jan;34(1):25-35. doi: 10.1007/s10585-016-9826-6. Epub 2016 Oct 15. PubMed PMID: 27744579.

50: Wang L, Chen Y, Li X, Zhang Y, Gulbins E, Zhang Y. Enhancement of endothelial permeability by free fatty acid through lysosomal cathepsin B-mediated Nlrp3 inflammasome activation. Oncotarget. 2016 Nov 8;7(45):73229-73241. doi: 10.18632/oncotarget.12302. PubMed PMID: 27689324; PubMed Central PMCID: PMC5341975.

51: Hollmann C, Werner S, Avota E, Reuter D, Japtok L, Kleuser B, Gulbins E, Becker KA, Schneider-Schaulies J, Beyersdorf N. Inhibition of Acid Sphingomyelinase Allows for Selective Targeting of CD4+ Conventional versus Foxp3+ Regulatory T Cells. J Immunol. 2016 Oct 15;197(8):3130-3141. Epub 2016 Sep 16. PubMed PMID: 27638864.

52: Makdessi SA, Sweidan H, Schmid E, Weimar U, Gulbins E, Lang F. Quantitative Determination of Ceramide Molecular Species in Dendritic Cells. Cell Physiol Biochem. 2016;39(4):1608-17. doi: 10.1159/000447862. Epub 2016 Sep 15. PubMed PMID: 27627650.

53: Hoehn RS, Seitz AP, Jernigan PL, Gulbins E, Edwards MJ. Ischemia/Reperfusion Injury Alters Sphingolipid Metabolism in the Gut. Cell Physiol Biochem. 2016;39(4):1262-70. doi: 10.1159/000447831. Epub 2016 Sep 8. PubMed PMID: 27607915.

54: Zoicas I, Reichel M, Gulbins E, Kornhuber J. Role of Acid Sphingomyelinase in the Regulation of Social Behavior and Memory. PLoS One. 2016 Sep 6;11(9):e0162498. doi: 10.1371/journal.pone.0162498. eCollection 2016. PubMed PMID: 27598773; PubMed Central PMCID: PMC5012580.

55: Nojima H, Konishi T, Freeman CM, Schuster RM, Japtok L, Kleuser B, Edwards MJ, Gulbins E, Lentsch AB. Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in Hepatocytes. PLoS One. 2016 Aug 23;11(8):e0161443. doi: 10.1371/journal.pone.0161443. eCollection 2016. PubMed PMID: 27551720; PubMed Central PMCID: PMC4995008.

56: Zhou Y, Salker MS, Walker B, Münzer P, Borst O, Gawaz M, Gulbins E, Singh Y, Lang F. Acid Sphingomyelinase (ASM) is a Negative Regulator of Regulatory T Cell (Treg) Development. Cell Physiol Biochem. 2016;39(3):985-95. doi: 10.1159/000447806. Epub 2016 Aug 12. PubMed PMID: 27512981.

57: Gulbins A, Grassmé H, Hoehn R, Kohnen M, Edwards MJ, Kornhuber J, Gulbins E. Role of Janus-Kinases in Major Depressive Disorder. Neurosignals. 2016;24(1):71-80. doi: 10.1159/000442613. Epub 2016 Aug 3. PubMed PMID: 27487096.

58: Gulbins A, Grassmé H, Hoehn R, Wilker B, Soddemann M, Kohnen M, Edwards MJ, Kornhuber J, Gulbins E. Regulation of Neuronal Stem Cell Proliferation in the Hippocampus by Endothelial Ceramide. Cell Physiol Biochem. 2016;39(2):790-801. doi: 10.1159/000447789. Epub 2016 Aug 1. PubMed PMID: 27475812.

59: Rice TC, Seitz AP, Edwards MJ, Gulbins E, Caldwell CC. Frontline Science: Sphingosine rescues burn-injured mice from pulmonary Pseudomonas aeruginosa infection. J Leukoc Biol. 2016 Dec;100(6):1233-1237. Epub 2016 Jul 14. PubMed PMID: 27418352.

60: Hoehn R, Monse M, Pohl E, Wranik S, Wilker B, Keitsch S, Soddemann M, Kornhuber J, Kohnen M, Edwards MJ, Grassmé H, Gulbins E. Melatonin Acts as an Antidepressant by Inhibition of the Acid Sphingomyelinase/Ceramide System. Neurosignals. 2016;24(1):48-58. doi: 10.1159/000442611. Epub 2016 Jul 11. PubMed PMID: 27398923.

61: Adams C, Icheva V, Deppisch C, Lauer J, Herrmann G, Graepler-Mainka U, Heyder S, Gulbins E, Riethmueller J. Long-Term Pulmonal Therapy of Cystic Fibrosis-Patients with Amitriptyline. Cell Physiol Biochem. 2016;39(2):565-72. doi: 10.1159/000445648. Epub 2016 Jul 11. PubMed PMID: 27395380.

62: Hoehn RS, Jernigan PL, Chang AL, Edwards MJ, Caldwell CC, Gulbins E, Pritts TA. Acid Sphingomyelinase Inhibition Prevents Hemolysis During Erythrocyte Storage. Cell Physiol Biochem. 2016;39(1):331-40. doi: 10.1159/000445627. Epub 2016 Jun 29. PubMed PMID: 27352097; PubMed Central PMCID: PMC5731776.

63: Schneider M, Levant B, Reichel M, Gulbins E, Kornhuber J, Müller CP. Lipids in psychiatric disorders and preventive medicine. Neurosci Biobehav Rev. 2017 May;76(Pt B):336-362. doi: 10.1016/j.neubiorev.2016.06.002. Epub 2016 Jun 16. Review. PubMed PMID: 27317860.

64: Tavakoli Tabazavareh S, Seitz A, Jernigan P, Sehl C, Keitsch S, Lang S, Kahl BC, Edwards M, Grassmé H, Gulbins E, Becker KA. Lack of Sphingosine Causes Susceptibility to Pulmonary Staphylococcus Aureus Infections in Cystic Fibrosis. Cell Physiol Biochem. 2016;38(6):2094-102. doi: 10.1159/000445567. Epub 2016 May 17. PubMed PMID: 27184795.

65: Folkesson M, Vorkapic E, Gulbins E, Japtok L, Kleuser B, Welander M, Länne T, Wågsäter D. Inflammatory cells, ceramides, and expression of proteases in perivascular adipose tissue adjacent to human abdominal aortic aneurysms. J Vasc Surg. 2017 Apr;65(4):1171-1179.e1. doi: 10.1016/j.jvs.2015.12.056. Epub 2016 Mar 6. PubMed PMID: 26960947.

66: Huston JP, Kornhuber J, Mühle C, Japtok L, Komorowski M, Mattern C, Reichel M, Gulbins E, Kleuser B, Topic B, De Souza Silva MA, Müller CP. A sphingolipid mechanism for behavioral extinction. J Neurochem. 2016 May;137(4):589-603. doi: 10.1111/jnc.13537. Epub 2016 Mar 15. PubMed PMID: 26788861.

67: Carpinteiro A, Beckmann N, Seitz A, Hessler G, Wilker B, Soddemann M, Helfrich I, Edelmann B, Gulbins E, Becker KA. Role of Acid Sphingomyelinase-Induced Signaling in Melanoma Cells for Hematogenous Tumor Metastasis. Cell Physiol Biochem. 2016;38(1):1-14. doi: 10.1159/000438604. Epub 2016 Jan 8. PubMed PMID: 26741636.

68: Lee H, Rotolo JA, Mesicek J, Penate-Medina T, Rimner A, Liao WC, Yin X, Ragupathi G, Ehleiter D, Gulbins E, Zhai D, Reed JC, Haimovitz-Friedman A, Fuks Z, Kolesnick R. Correction: Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation. PLoS One. 2015 Dec 30;10(12):e0146210. doi: 10.1371/journal.pone.0146210. eCollection 2015. PubMed PMID: 26716446; PubMed Central PMCID: PMC4696794.

69: Li C, Peng H, Japtok L, Seitz A, Riehle A, Wilker B, Soddemann M, Kleuser B, Edwards M, Lammas D, Zhang Y, Gulbins E, Grassme H. Inhibition of neutral sphingomyelinase protects mice against systemic tuberculosis. Front Biosci (Elite Ed). 2016 Jan 1;8:311-25. PubMed PMID: 26709664.

70: Jernigan PL, Hoehn RS, Grassmé H, Edwards MJ, Müller CP, Kornhuber J, Gulbins E. Sphingolipids in Major Depression. Neurosignals. 2015;23(1):49-58. doi: 10.1159/000442603. Epub 2015 Dec 19. Review. PubMed PMID: 26684792.

71: Grassmé H, Jernigan PL, Hoehn RS, Wilker B, Soddemann M, Edwards MJ, Müller CP, Kornhuber J, Gulbins E. Inhibition of Acid Sphingomyelinase by Antidepressants Counteracts Stress-Induced Activation of P38-Kinase in Major Depression. Neurosignals. 2015;23(1):84-92. doi: 10.1159/000442606. Epub 2015 Dec 19. PubMed PMID: 26682751.

72: Leanza L, Managò A, Zoratti M, Gulbins E, Szabo I. Pharmacological targeting of ion channels for cancer therapy: In vivo evidences. Biochim Biophys Acta. 2016 Jun;1863(6 Pt B):1385-97. doi: 10.1016/j.bbamcr.2015.11.032. Epub 2015 Nov 30. Review. PubMed PMID: 26658642.

73: Managò A, Leanza L, Carraretto L, Sassi N, Grancara S, Quintana-Cabrera R, Trimarco V, Toninello A, Scorrano L, Trentin L, Semenzato G, Gulbins E, Zoratti M, Szabò I. Early effects of the antineoplastic agent salinomycin on mitochondrial function. Cell Death Dis. 2015 Oct 22;6:e1930. doi: 10.1038/cddis.2015.263. PubMed PMID: 26492365; PubMed Central PMCID: PMC4632293.

74: Schumacher F, Chakraborty S, Kleuser B, Gulbins E, Schwerdtle T, Aschner M, Bornhorst J. Highly sensitive isotope-dilution liquid-chromatography-electrospray ionization-tandem-mass spectrometry approach to study the drug-mediated modulation of dopamine and serotonin levels in Caenorhabditis elegans. Talanta. 2015 Nov 1;144:71-9. doi: 10.1016/j.talanta.2015.05.057. Epub 2015 May 28. PubMed PMID: 26452793; PubMed Central PMCID: PMC4600537.

75: Reichel M, Hönig S, Liebisch G, Lüth A, Kleuser B, Gulbins E, Schmitz G, Kornhuber J. Alterations of plasma glycerophospholipid and sphingolipid species in male alcohol-dependent patients. Biochim Biophys Acta. 2015 Nov;1851(11):1501-10. doi: 10.1016/j.bbalip.2015.08.005. Epub 2015 Aug 17. PubMed PMID: 26291032.

76: Merches K, Khairnar V, Knuschke T, Shaabani N, Honke N, Duhan V, Recher M, Navarini AA, Hardt C, Häussinger D, Tümmler B, Gulbins E, Futerman AH, Hoffmann D, Lang F, Lang PA, Westendorf AM, Lang KS. Virus-Induced Type I Interferon Deteriorates Control of Systemic Pseudomonas Aeruginosa Infection. Cell Physiol Biochem. 2015;36(6):2379-92. doi: 10.1159/000430200. Epub 2015 Jul 27. PubMed PMID: 26279441.

77: Nojima H, Freeman CM, Schuster RM, Japtok L, Kleuser B, Edwards MJ, Gulbins E, Lentsch AB. Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate. J Hepatol. 2016 Jan;64(1):60-8. doi: 10.1016/j.jhep.2015.07.030. Epub 2015 Aug 5. PubMed PMID: 26254847; PubMed Central PMCID: PMC4843792.

78: Gulbins E, Walter S, Becker KA, Halmer R, Liu Y, Reichel M, Edwards MJ, Müller CP, Fassbender K, Kornhuber J. A central role for the acid sphingomyelinase/ceramide system in neurogenesis and major depression. J Neurochem. 2015 Jul;134(2):183-92. doi: 10.1111/jnc.13145. Epub 2015 May 23. Review. PubMed PMID: 25925550.

79: Gulbins E. Highlight: molecular medicine of sphingolipids. Biol Chem. 2015 Jun;396(6-7):569-71. doi: 10.1515/hsz-2015-0163. PubMed PMID: 25910400.

80: Carpinteiro A, Becker KA, Japtok L, Hessler G, Keitsch S, Požgajovà M, Schmid KW, Adams C, Müller S, Kleuser B, Edwards MJ, Grassmé H, Helfrich I, Gulbins E. Regulation of hematogenous tumor metastasis by acid sphingomyelinase. EMBO Mol Med. 2015 Jun;7(6):714-34. doi: 10.15252/emmm.201404571. PubMed PMID: 25851537; PubMed Central PMCID: PMC4459814.

81: Nojima H, Freeman CM, Gulbins E, Lentsch AB. Sphingolipids in liver injury, repair and regeneration. Biol Chem. 2015 Jun;396(6-7):633-43. doi: 10.1515/hsz-2014-0296. Review. PubMed PMID: 25781682.

82: Seitz AP, Grassmé H, Edwards MJ, Pewzner-Jung Y, Gulbins E. Ceramide and sphingosine in pulmonary infections. Biol Chem. 2015 Jun;396(6-7):611-20. doi: 10.1515/hsz-2014-0285. PubMed PMID: 25720061.

83: Managò A, Becker KA, Carpinteiro A, Wilker B, Soddemann M, Seitz AP, Edwards MJ, Grassmé H, Szabò I, Gulbins E. Pseudomonas aeruginosa pyocyanin induces neutrophil death via mitochondrial reactive oxygen species and mitochondrial acid sphingomyelinase. Antioxid Redox Signal. 2015 May 1;22(13):1097-110. doi: 10.1089/ars.2014.5979. Epub 2015 Mar 18. PubMed PMID: 25686490; PubMed Central PMCID: PMC4403017.

84: Lang E, Bissinger R, Gulbins E, Lang F. Ceramide in the regulation of eryptosis, the suicidal erythrocyte death. Apoptosis. 2015 May;20(5):758-67. doi: 10.1007/s10495-015-1094-4. Review. PubMed PMID: 25637185.

85: Peng H, Li C, Kadow S, Henry BD, Steinmann J, Becker KA, Riehle A, Beckmann N, Wilker B, Li PL, Pritts T, Edwards MJ, Zhang Y, Gulbins E, Grassmé H. Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis. J Mol Med (Berl). 2015 Jun;93(6):675-89. doi: 10.1007/s00109-014-1246-y. Epub 2015 Jan 25. PubMed PMID: 25616357; PubMed Central PMCID: PMC4432103.

86: Müller CP, Reichel M, Mühle C, Rhein C, Gulbins E, Kornhuber J. Brain membrane lipids in major depression and anxiety disorders. Biochim Biophys Acta. 2015 Aug;1851(8):1052-65. doi: 10.1016/j.bbalip.2014.12.014. Epub 2014 Dec 24. Review. PubMed PMID: 25542508.

87: Chen Y, Li X, Boini KM, Pitzer AL, Gulbins E, Zhang Y, Li PL. Endothelial Nlrp3 inflammasome activation associated with lysosomal destabilization during coronary arteritis. Biochim Biophys Acta. 2015 Feb;1853(2):396-408. doi: 10.1016/j.bbamcr.2014.11.012. Epub 2014 Nov 15. PubMed PMID: 25450976; PubMed Central PMCID: PMC4289419.

88: Leanza L, Venturini E, Kadow S, Carpinteiro A, Gulbins E, Becker KA. Targeting a mitochondrial potassium channel to fight cancer. Cell Calcium. 2015 Jul;58(1):131-8. doi: 10.1016/j.ceca.2014.09.006. Epub 2014 Oct 18. Review. PubMed PMID: 25443654.

89: Henry BD, Neill DR, Becker KA, Gore S, Bricio-Moreno L, Ziobro R, Edwards MJ, Mühlemann K, Steinmann J, Kleuser B, Japtok L, Luginbühl M, Wolfmeier H, Scherag A, Gulbins E, Kadioglu A, Draeger A, Babiychuk EB. Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice. Nat Biotechnol. 2015 Jan;33(1):81-8. doi: 10.1038/nbt.3037. Epub 2014 Nov 2. PubMed PMID: 25362245.

90: Beckmann N, Sharma D, Gulbins E, Becker KA, Edelmann B. Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons. Front Physiol. 2014 Sep 2;5:331. doi: 10.3389/fphys.2014.00331. eCollection 2014. Review. PubMed PMID: 25228885; PubMed Central PMCID: PMC4151525.

91: Hilker R, Munder A, Klockgether J, Losada PM, Chouvarine P, Cramer N, Davenport CF, Dethlefsen S, Fischer S, Peng H, Schönfelder T, Türk O, Wiehlmann L, Wölbeling F, Gulbins E, Goesmann A, Tümmler B. Interclonal gradient of virulence in the Pseudomonas aeruginosa pangenome from disease and environment. Environ Microbiol. 2015 Jan;17(1):29-46. doi: 10.1111/1462-2920.12606. Epub 2014 Sep 29. PubMed PMID: 25156090.

92: Neuber C, Schumacher F, Gulbins E, Kleuser B. Method to simultaneously determine the sphingosine 1-phosphate breakdown product (2E)-hexadecenal and its fatty acid derivatives using isotope-dilution HPLC-electrospray ionization-quadrupole/time-of-flight mass spectrometry. Anal Chem. 2014 Sep 16;86(18):9065-73. doi: 10.1021/ac501677y. Epub 2014 Sep 3. PubMed PMID: 25137547.

93: Pewzner-Jung Y, Tavakoli Tabazavareh S, Grassmé H, Becker KA, Japtok L, Steinmann J, Joseph T, Lang S, Tuemmler B, Schuchman EH, Lentsch AB, Kleuser B, Edwards MJ, Futerman AH, Gulbins E. Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa. EMBO Mol Med. 2014 Sep;6(9):1205-14. doi: 10.15252/emmm.201404075. PubMed PMID: 25085879; PubMed Central PMCID: PMC4197866.

94: Lang E, Gatidis S, Freise NF, Bock H, Kubitz R, Lauermann C, Orth HM, Klindt C, Schuier M, Keitel V, Reich M, Liu G, Schmidt S, Xu HC, Qadri SM, Herebian D, Pandyra AA, Mayatepek E, Gulbins E, Lang F, Häussinger D, Lang KS, Föller M, Lang PA. Conjugated bilirubin triggers anemia by inducing erythrocyte death. Hepatology. 2015 Jan;61(1):275-84. doi: 10.1002/hep.27338. Epub 2014 Nov 24. PubMed PMID: 25065608; PubMed Central PMCID: PMC4303990.