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Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
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Multiple myeloma in the young : Insights on prognosis, clinical features and treatment outcome derived from nationwide German registry data and a nested multicenter sampleIn: Haematologica / The Hematology Journal Jg. 109 (2024) Nr. 11, S. 3795 - 3799Online Volltext: dx.doi.org/ (Open Access)
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Combination Treatment Targeting mTOR and MAPK Pathways Has Synergistic Activity in Multiple MyelomaIn: Cancers Jg. 15 (2023) Nr. 8, 2373Online Volltext: dx.doi.org/ (Open Access)
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Dose-dependent effect of GFI1 expression in the reconstitution and the differentiation capacity of HSCsIn: Frontiers in Cell and Developmental Biology Jg. 11 (2023) 866847Online Volltext: dx.doi.org/ (Open Access)
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Dose-dependent expression of GFI1 alters metabolism in the haematopoietic progenitors and MLL::AF9-induced leukaemic cellsIn: British Journal of Haematology Jg. 202 (2023) Nr. 5, S. 1033 - 1048Online Volltext: dx.doi.org/ (Open Access)
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Germ line variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapyIn: Blood Jg. 142 (2023) Nr. 25, S. 2175 - 2191Online Volltext: dx.doi.org/ (Open Access)
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Addition of isatuximab to lenalidomide, bortezomib, and dexamethasone as induction therapy for newly diagnosed, transplantation-eligible patients with multiple myeloma (GMMG-HD7) : Part 1 of an open-label, multicentre, randomised, active-controlled, phase 3 trialIn: The Lancet Haematology Jg. 9 (2022) Nr. 11, S. e810 - e821Online Volltext: dx.doi.org/
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Curcumin as an epigenetic therapeutic agent in myelodysplastic syndromes (Mds)In: International Journal of Molecular Sciences (IJMS) Jg. 23 (2022) Nr. 1, 411Online Volltext: dx.doi.org/ (Open Access)
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Dexamethasone-mediated inhibition of Notch signalling blocks the interaction of leukaemia and mesenchymal stromal cellsIn: British Journal of Haematology Jg. 196 (2022) Nr. 4, S. 995 - 1006Online Volltext: dx.doi.org/ (Open Access)
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GFI1B acts as a metabolic regulator in hematopoiesis and acute myeloid leukemiaIn: Leukemia Jg. 36 (2022) Nr. 9, S. 2196 - 2207Online Volltext: dx.doi.org/ (Open Access)
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High Metabolic Dependence on Oxidative Phosphorylation Drives Sensitivity to Metformin Treatment in MLL/AF9 Acute Myeloid LeukemiaIn: Cancers Jg. 14 (2022) Nr. 3, 486Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Presence of the GFI1-36N single nucleotide polymorphism enhances the response of MLL-AF9 leukemic cells to CDK4/6 inhibitionIn: Frontiers in Oncology Jg. 12 (2022) 903691Online Volltext: dx.doi.org/ (Open Access)
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Reduced expression but not deficiency of GFI1 causes a fatal myeloproliferative disease in miceIn: Leukemia Jg. 33 (2019) Nr. 1, S. 110 - 121Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1.In: Nature Communications Jg. 9 (2018) S. 1418Online Volltext: dx.doi.org/ (Open Access)
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GFI1 is required for RUNX1/ETO positive acute myeloid leukemiaIn: Haematologica / The Hematology Journal Jg. 103 (2018) Nr. 9, S. e395 - e399Online Volltext: dx.doi.org/ (Open Access)
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Gfi1b : A key player in the genesis and maintenance of acute myeloid leukemia and myelodysplastic syndromeIn: Haematologica / The Hematology Journal Jg. 103 (2018) Nr. 4, S. 614 - 625Online Volltext: dx.doi.org/ (Open Access)
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Enforced GFI1 expression impedes human and murine leukemic cell growth.In: Scientific Reports Jg. 7 (2017) S. 15720Online Volltext: dx.doi.org/ (Open Access)
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GFI1B-A novel oncosuppressor which restricts number of leukemic stem stellsIn: Haematologica / The Hematology Journal Jg. 102 (2017) Nr. Suppl. 2, S. 204 - 204
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Growth factor independence 1 (GFI !) regulates the AML supporting function of mesenchymal stromal cellsIn: Haematologica / The Hematology Journal Jg. 102 (2017) Nr. Suppl. 2, S. 459 - 459
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Myelodysplastic syndromes and bone loss in mice and menIn: Leukemia Jg. 31 (2017) Nr. 4, S. 1003 - 1007Online Volltext: dx.doi.org/
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A 6-Base Pair in Frame Germline Deletion in Exon 7 Of RET Leads to Increased RET Phosphorylation, ERK Activation, and MEN2AIn: The Journal of Clinical Endocrinology & Metabolism (JCEM) Jg. 101 (2016) Nr. 3, S. 1016 - 1022Online Volltext: dx.doi.org/ (Open Access)
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Acute myeloid leukemia cells polarize macrophages towards a leukemia supporting state in a Growth factor independence 1 dependent mannerIn: Haematologica / The Hematology Journal Jg. 101 (2016) Nr. 10, S. 1216 - 1227Online Volltext: dx.doi.org/ (Open Access)
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Bone homeostasis is altered in a mouse model of myelodysplastic syndromeIn: Oncology Research and Treatment Jg. 39 (2016) Nr. Suppl. 3, S. 123 - 123
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Bone homeostasis is significantly altered in a myelodysplastic syndrome mouse modelIn: Haematologica / The Hematology Journal Jg. 101 1 (2016) S. 493 - 493(Open Access)
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Epigenetic therapy as a novel approach for GFI136N-associated murine/human AMLIn: Experimental Hematology Jg. 44 (2016) Nr. 8, S. 713 - 726.e14Online Volltext: dx.doi.org/ (Open Access)
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Functional inhibition of mesenchymal stromal cells in acute myeloid leukemiaIn: Leukemia Jg. 30 (2016) Nr. 3, S. 683 - 691Online Volltext: dx.doi.org/
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GFI1 as a novel prognostic and therapeutic factor for AML/MDSIn: Leukemia Jg. 30 (2016) Nr. 6, S. 1237 - 1245Online Volltext: dx.doi.org/
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GFI136N as a therapeutic and prognostic marker for myelodysplastic syndromeIn: Experimental Hematology Jg. 44 (2016) Nr. 7, S. 590 - 595.e1Online Volltext: dx.doi.org/ (Open Access)
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High Frequencies of Anti-Host Reactive CD8+ T Cells Ignore Non-Hematopoietic Antigen after Bone Marrow Transplantation in a Murine ModelIn: Cellular Physiology and Biochemistry Jg. 38 (2016) Nr. 4, S. 1343 - 1353Online Volltext: dx.doi.org/ (Open Access)
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Low GFI1 expression level drive the development of acute myeloid leukemia and fatal myeloproliferative neoplasia by blocking differentiation and P53-mediated apoptosisIn: Experimental Hematology Jg. 44 1 (2016) Nr. 9, S. 71 - S71Online Volltext: dx.doi.org/
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Threshold Levels of Gfi1 Maintain E2A Activity for B Cell Commitment via Repression of Id1In: PLoS ONE Jg. 11 (2016) Nr. 7, S. e0160344Online Volltext: dx.doi.org/ (Open Access)
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Virus-specific antibodies allow viral replication in the marginal zone, thereby promoting CD8 + T-cell priming and viral controlIn: Scientific Reports Jg. 6 (2016) S. 19191Online Volltext: dx.doi.org/ (Open Access)
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72 personalized treatment approach for GFI 136N heterozygous or homozygous MDS patientsIn: Leukemia Research Jg. 39 (2015) Nr. Suppl. 1, S. S35Online Volltext: dx.doi.org/
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From cytopenia to leukemia : the role of Gfi1 and Gfi1b in blood formationIn: Blood Jg. 126 (2015) Nr. 24, S. 2561 - 2569Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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A dominant-negative GFI1B mutation in the gray platelet syndromeIn: The New England Journal of Medicine Jg. 370 (2014) Nr. 3, S. 245 - 253Online Volltext: dx.doi.org/ (Open Access)
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Gfi1 as a novel prognostic marker and tumor suppressor in acute myeloid leukemiaIn: Onkologie Jg. 36 7 (2013) S. 193 - 193
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Gfi1 as a regulator of p53 and a therapeutic target for ALLIn: OncoTarget Jg. 4 (2013) Nr. 3, S. 374 - 375Online Volltext: dx.doi.org/
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Gfi136N is a novel prognostic marker for the progression of myelodysplastic syndrome to Acute myeloid leukemiaIn: Onkologie Jg. 36 (2013) Nr. Suppl. 7, S. 188 - 188
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Growth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemiaIn: Cancer Cell Jg. 23 (2013) Nr. 2, S. 200 - 214Online Volltext: dx.doi.org/ (Open Access)
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Hand-foot syndrome : common presentation in an uncommon situationIn: European Journal of Haematology Jg. 91 (2013) Nr. 5, S. 472Online Volltext: dx.doi.org/
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Leukämien : Modellkrankheiten für die Entstehung und Behandlung von KrebsIn: Unikate: Berichte aus Forschung und Lehre (2013) Nr. 44: Medizin : 50 Jahre Universitätsklinikum Essen, S. 114 - 125Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Origin of the brush cell lineage in the mouse intestinal epitheliumIn: Developmental Biology Jg. 362 (2012) Nr. 2, S. 194 - 218Online Volltext: dx.doi.org/
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The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in miceIn: Blood Jg. 120 (2012) Nr. 19, S. 4006 - 4017Online Volltext: dx.doi.org/
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Growth factor independence 1 (Gfi1) as a regulator of lymphocyte development and activationIn: Seminars in immunology Jg. 23 (2011) Nr. 5, S. 368 - 378Online Volltext: dx.doi.org/
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Growth factor independence 1 protects hematopoietic stem cells against apoptosis but also prevents the development of a myeloproliferative-like diseaseIn: Stem Cells Jg. 29 (2011) Nr. 2, S. 376 - 385Online Volltext: dx.doi.org/
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A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemiaIn: Blood Jg. 115 (2010) Nr. 12, S. 2462 - 2472Online Volltext: dx.doi.org/
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Evidence that Growth factor independence 1b (Gfi1b) regulates dormancy and peripheral blood mobilization of hematopoietic stem cellsIn: Blood Jg. 116 (2010) Nr. 24, S. 5149 - 5161Online Volltext: dx.doi.org/
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Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65In: Molecular and Cellular Biology (MCB) Jg. 30 (2010) Nr. 16, S. 3929 - 3942Online Volltext: dx.doi.org/
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Growth factor independent 1b (Gfi1b) and a new splice variant of Gfi1b are highly expressed in patients with acute and chronic leukemiaIn: International Journal of Hematology Jg. 89 (2009) Nr. 4, S. 422 - 430Online Volltext: dx.doi.org/
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The zinc finger protein Gfi1 is implicated in the regulation of IgG2b production and the expression of Iγ2b germline transcriptsIn: European Journal of Immunology Jg. 38 (2008) Nr. 11, S. 2916 - 3244Online Volltext: dx.doi.org/
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Germline variant GFI1-36N affects DNA repair in AML cells resulting in sensitivity to DNA damage and repair therapy
Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie ; 13. bis 16. Oktober 2023, Hamburg, Germany,In: Oncology Research and Treatment Jg. 46 (2023) Nr. Supplement 5: DGHO Abstracts, S. 135Online Volltext: dx.doi.org/ (Open Access) -
Growth factor independence 1 expression regulates acute myeloid leukemia cell metabolism by regulating the equilibrium between the rate of glycolysis and oxidative phosphorylation
Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie ; 13. bis 16. Oktober 2023, Hamburg, Germany,In: Oncology Research and Treatment Jg. 46 (2023) Nr. Supplement 5: DGHO Abstracts, S. 138Online Volltext: dx.doi.org/ (Open Access) -
Addition of Isatuximab to Lenalidomide, Bortezomib and Dexamethasone As Induction Therapy for Newly-Diagnosed, Transplant-Eligible Multiple Myeloma Patients : The Phase III GMMG-HD7 Trial
63rd ASH Annual Meeting and Exposition, 11-14 December 2021, Atlanta,In: Blood Jg. 138 (2021) Nr. Supplement 1: 63rd ASH Annual Meeting Abstracts, S. 463 - 465Online Volltext: dx.doi.org/ (Open Access) -
Leukaemia Cells Induced Metabolic Alterations in AML Associated Mesenchymal Stem Cells Via Notch Signalling
63rd ASH Annual Meeting and Exposition, 11-14 December 2021, Atlanta,In: Blood Jg. 138 (2021) Nr. Supplement 1: 63rd ASH Annual Meeting Abstracts, S. 4347 - 4348Online Volltext: dx.doi.org/ (Open Access) -
Growth factor independence 1 expression induced metabolic vulnerabilities and presents novel therapeutic opportunities in acute myeloid leukemia
Virtuelle Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie, 09.–11. Oktober 2020,In: Oncology Research and Treatment Jg. 43 (2020) Nr. Suppl. 4, S. 43 - 44Online Volltext: dx.doi.org/ (Open Access) -
Curcumin as a treatment approach for MDS/AML in human
Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie ; 28. September - 2. Oktober 2018, Wien,In: Oncology Research and Treatment Jg. 41 (2018) Nr. Suppl. 4, S. 76Online Volltext: dx.doi.org/ (Open Access) -
The bone marrow niche as a potential target to improve the outcome of acute myeoloid leukemia using dexamethasone
Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie ; 28. September - 2. Oktober 2018, Wien,In: Oncology Research and Treatment Jg. 41 (2018) Nr. Suppl. 4, S. 73 - 74Online Volltext: dx.doi.org/ (Open Access) -
Growth Factor Independent-1 (Gfi1) Is Critically Required for T-Cell Acute Lymphoblastic Leukemia (T-ALL) Tumor Initiation and MaintenanceIn: Blood Jg. 116 (2010) Nr. 21, S. 1299Online Volltext: dx.doi.org/
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Funktion der Transkriptonsfaktoren Gfi1 und Gfi1b in der physiologischen und malignen Entwicklung des hämatopoetischen SystemsDuisburg ; Essen (2017) 1 CD-ROM
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Affinitätschromatographie mit orientiert und nicht-orientiert immobilisiertem Calmodulin am Beispiel der Aufreinigung der Ubiquityl-Calmodulin-Synthetase Faktor 2Duisburg-Essen (2005) 99 Bl. : Ill., graph. Darst.
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Entwicklungen im Überleben beim Multiplen Myelom : eine Analyse des Krebsregisters NRW
Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie, 7.–10. Oktober 2022, Wien, Austria,In: Oncology Research and Treatment Jg. 45 (2022) Nr. Supplement 2, S. 85 - 86Online Volltext: dx.doi.org/ (Open Access)