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Prof. Dr. rer. nat. Carsten Jürgen Kirschning

Institut für Medizinische Mikrobiologie am Universitätsklinikum Essen

Anschrift
Hufelandstr. 55
45122 Essen
Telefon
0201/723 1824
E-Mail
Carsten.Kirschning@uk-essen.de

Funktionen

  • Universitätsprofessor/in, Institut für Medizinische Mikrobiologie

Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.

    Artikel in Zeitschriften

  • Dyckhoff-Shen, Susanne; Masouris, Ilias; Islam, Heba; Hammerschmidt, Sven; Angele, Barbara; Marathe, Veena; Buer, Jan; Völk, Stefanie; Pfister, Hans-Walter; Klein, Matthias; Koedel, Uwe; Kirschning, Carsten J.
    Combining antibiotic with anti-TLR2/ TLR13 therapy prevents brain pathology in pneumococcal meningitis
    In: JCI Insight Jg. 9 (2024) Nr. 6, e165737
    Online Volltext: dx.doi.org/ (Open Access)
  • Madel, Rabea J.; Börger, Verena; Dittrich, Robin; Bremer, Michel; Tertel, Tobias; Phuong, Nhi Ngo Thi; Baba, Hideo Andreas; Kordelas, Lambros; Staubach, Simon; Stein, Frank; Haberkant, Per; Hackl, Matthias; Grillari, Regina; Grillari, Johannes; Buer, Jan; Horn, Peter; Westendorf, Astrid; Brandau, Sven; Kirschning, Carsten Jürgen; Giebel, Bernd
    Independent human mesenchymal stromal cell–derived extracellular vesicle preparations differentially attenuate symptoms in an advanced murine graft-versus-host disease model
    In: Cytotherapy (2023)
    Online Volltext: dx.doi.org/ (Open Access)
  • Buys, Willem; Bick, Alexandra; Madel, Rabea J.; Westendorf, Astrid; Buer, Jan; Herbstreit, Frank; Kirschning, Carsten Jürgen; Peters, Jürgen
    Substantial heterogeneity of inflammatory cytokine production and its inhibition by a triple cocktail of toll-like receptor blockers in early sepsis
    In: Frontiers in Immunology Jg. 14 (2023) 1277033
    Online Volltext: dx.doi.org/; Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Wyczanska, Maja; Rohling, Jana; Keller, Ursula; Benz, Marcus R.; Kirschning, Carsten; Lange-Sperandio, Bärbel
    TLR2 mediates renal apoptosis in neonatal mice subjected experimentally to obstructive nephropathy
    In: PLoS ONE Jg. 18 (2023) Nr. 11, e0294142
    Online Volltext: dx.doi.org/ (Open Access)
  • Wilk, Camilla; Effenberg, Laura; Abberger, Hanna; Steenpass, Laura; Hansen, Wiebke; Zeschnigk, Michael; Kirschning, Carsten Jürgen; Buer, Jan; Kehrmann, Jan
    CRISPR/Cas9-mediated demethylation of FOXP3-TSDR toward Treg-characteristic programming of Jurkat T cells
    In: Cellular Immunology Jg. 371 (2022) 104471
    Online Volltext: dx.doi.org/
  • Meng, Guangxun; Kirschning, Carsten Jürgen; Zhou, Rongbin
    Editorial: Patho- and Physiological Roles of Inflammasomes
    In: Frontiers in Immunology Jg. 13 (2022) 857929
    Online Volltext: dx.doi.org/ (Open Access)
  • Bick, Alexandra; Buys, Willem; Engler, Andrea; Madel, Rabea; Atia, Mazen; Faro, Francesca; Westendorf, Astrid; Limmer, Andreas; Buer, Jan; Herbstreit, Frank; Kirschning, Carsten Jürgen; Peters, Jürgen
    Immune hyporeactivity to bacteria and multiple TLR-ligands, yet no response to checkpoint inhibition in patients just after meeting Sepsis-3 criteria
    In: PLoS ONE Jg. 17 (2022) Nr. 8, e0273247
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Yang, Xiaoli; Ali, Shafaqat; Zhao, Manman; Richter, Lisa; Schäfer, Vanessa; Schliehe-Diecks, Julian; Frank, Marian; Qi, Jing; Larsen, Pia-Katharina; Skerra, Jennifer; Islam, Heba; Wachtmeister, Thorsten; Alter, Christina; Huang, Anfei; Bhatia, Sanil; Köhrer, Karl; Kirschning, Carsten Jürgen; Weighardt, Heike; Kalinke, Ulrich; Kalscheuer, Rainer; Uhrberg, Markus; Scheu, Stefanie
    The Mycotoxin Beauvericin Exhibits Immunostimulatory Effects on Dendritic Cells via Activating the TLR4 Signaling Pathway
    In: Frontiers in Immunology Jg. 13 (2022) 856230
    Online Volltext: dx.doi.org/ (Open Access)
  • Teske, Nina C.; Engelen-Lee, Joo-Yeon; Dyckhoff-Shen, Susanne; Pfister, Hans-Walter; Klein, Matthias; van de Beek, Diederik; Kirschning, Carsten Jürgen; Koedel, Uwe; Brouwer, Matthijs C.
    The role of plasminogen activator inhibitor-2 in pneumococcal meningitis
    In: Acta Neuropathologica Communications Jg. 10 (2022) Nr. 1, 155
    Online Volltext: dx.doi.org/ (Open Access)
  • Li, Qian; Wang, Jun; Islam, Heba; Kirschning, Carsten Jürgen; Lu, Hongzhou; Hoffmann, Daniel; Dittmer, Ulf; Lu, Mengji
    Hepatitis B virus particles activate B cells through the TLR2–MyD88–mTOR axis
    In: Cell Death and Disease Jg. 12 (2021) Nr. 1, 34
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Kibler, Artur; Budeus, Bettina; Homp, Ekaterina; Bronischewski, Kevin; Berg, Victoria; Sellmann, Ludger; Murke, Florian; Heinold, Andreas; Heinemann, Falko M.; Lindemann, Monika; Bekeredjian-Ding, Isabelle; Horn, Peter; Kirschning, Carsten Jürgen; Küppers, Ralf; Seifert, Marc
    Systematic memory B cell archiving and random display shape the human splenic marginal zone throughout life
    In: Journal of Experimental Medicine (JEM) Jg. 218 (2021) Nr. 4, S. e20201952
    Online Volltext: dx.doi.org/ (Open Access)
  • Kleinertz, Holger; Hepner-Schefczyk, Monika; Ehnert, Sabrina; Claus, Maren; Halbgebauer, Rebecca; Boller, Lea; Huber-Lang, Markus; Cinelli, Paolo; Kirschning, Carsten Jürgen; Flohé, Sascha; Sander, André; Waydhas, Christian; Vonderhagen, Sonja; Jäger, Marcus; Dudda, Marcel; Watzl, Carsten; Flohe, Stefanie
    Circulating growth/differentiation factor 15 is associated with human CD56(bright) natural killer cell dysfunction and nosocomial infection in severe systemic inflammation
    In: EBioMedicine Jg. 43 (2019) S. 380 - 391
    Online Volltext: dx.doi.org/ (Open Access)
  • Heß, Rebecca; Storcksdieck Genannt Bonsmann, Michael; Lapuente, Dennis; Maaske, Andre; Kirschning, Carsten Jürgen; Ruland, Jürgen; Lepenies, Bernd; Hannaman, Drew; Tenbusch, Matthias; Überla, Klaus
    Glycosylation of HIV Env Impacts IgG Subtype Responses to Vaccination
    In: Viruses Jg. 11 (2019) Nr. 2, S. 153
    Online Volltext: dx.doi.org/ (Open Access)
  • Madel, R.; Borger, V.; Bremer, M.; Horn, Peter; Baba, Hideo Andreas; Brandau, Sven; Buer, Jan; Giebel, Bernd; Kirschning, Carsten Jürgen
    MSC-EVS protect mice from graft-versus-host disease pathology in a preparation dependent manner
    In: Cytotherapy Jg. 21 (2019) Nr. Suppl. 5, S. 57
    Online Volltext: dx.doi.org/
  • Fleming, Viktor; Hu, Xiaoying; Weller, Céline; Weber, Rebekka; Groth, Christopher; Riester, Zeno; Hüser, Laura; Sun, Qian; Nagibin, Vasyl; Kirschning, Carsten Jürgen; Bronte, Vincenzo; Utikal, Jochen; Altevogt, Peter; Umansky, Viktor
    Melanoma extracellular vesicles generate immunosuppressive myeloid cells by upregulating PD-L1 via TLR4 signaling
    In: Cancer Research Jg. 79 (2019) Nr. 18, S. 4715 - 4728
    Online Volltext: dx.doi.org/ (Open Access)
  • Zhang, Ejuan; Ma, Zhiyong; Li, Qian; Yan, Hu; Liu, Jia; Wu, Weimin; Guo, Jiabao; Zhang, Xiaoyong; Kirschning, Carsten Jürgen; Xu, Haifeng; Lang, Philipp A.; Yang, Dongliang; Dittmer, Ulf; Yan, Huimin; Lu, Mengji
    TLR2 stimulation increases cellular metabolism in CD8⁺ T cells and thereby enhances CD8⁺ T cell activation, function, and antiviral activity
    In: The Journal of Immunology (JI) Jg. 203 (2019) Nr. 11, S. 2872 - 2886
    Online Volltext: dx.doi.org/ (Open Access)
  • Li, Qian; Yan, Yan; Liu, Jia; Huang, Xuan; Zhang, Xiaoyong; Kirschning, Carsten Jürgen; Xu, Haifeng C.; Lang, Philipp A.; Dittmer, Ulf; Zhang, Ejuan; Lu, Mengji
    Toll-Like Receptor 7 Activation Enhances CD8+ T Cell Effector Functions by Promoting Cellular Glycolysis
    In: Frontiers in Immunology Jg. 10 (2019) S. 2191
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Robak, Oliver H.; Heimesaat, Markus M.; Kruglov, Andrey A.; Prepens, Sandra; Ninnemann, Justus; Gutbier, Birgitt; Reppe, Katrin; Hochrein, Hubertus; Suter, Mark; Kirschning, Carsten Jürgen; Marathe, Veena; Buer, Jan; Hornef, Mathias W.; Schnare, Markus; Schneider, Pascal; Witzenrath, Martin; Bereswill, Stefan; Steinhoff, Ulrich; Suttorp, Norbert; Sander, Leif E.; Chaput, Catherine; Opitz, Bastian
    Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia
    In: The Journal of Clinical Investigation (JCI) Jg. 128 (2018) Nr. 8, S. 3535 - 3545
    Online Volltext: dx.doi.org/ (Open Access)
  • Gharun, Kourosh; Senges, Julia; Seidl, Maximilian; Lösslein, Anne; Kolter, Julia; Lohrmann, Florens; Fliegauf, Manfred; Elgizouli, Magdeldin; Alber, Marco; Vavra, Martina; Schachtrup, Kristina; Illert, Anna L; Gilleron, Martine; Kirschning, Carsten Jürgen; Triantafyllopoulou, Antigoni; Henneke, Philipp
    Corrigendum: Mycobacteria exploit nitric oxide-induced transformation of macrophages into permissive giant cells
    In: EMBO Reports Jg. 19 (2018) Nr. 12, S. e47190
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Klein, Johanna C.; Moses, Katrin; Zelinskyy, Gennadiy; Sody, Simon; Buer, Jan; Lang, Stephan; Helfrich, Iris; Dittmer, Ulf; Kirschning, Carsten Jürgen; Brandau, Sven
    Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth
    In: Nature Communications Jg. 8 (2017) S. 14600
    Online Volltext: dx.doi.org/ (Open Access)
  • Krieg, Sandro M; Voigt, Florian; Knuefermann, Pascal; Kirschning, Carsten Jürgen; Plesnila, Nikolaus; Ringel, Florian
    Decreased Secondary Lesion Growth and Attenuated Immune Response after Traumatic Brain Injury in Tlr2/4-/- Mice.
    In: Frontiers in Neurology Jg. 8 (2017) S. 455
    Online Volltext: dx.doi.org/ (Open Access)
  • Stein, Karina; Brand, Stephanie; Jenckel, André; Sigmund, Anna; Chen, Zhijian James; Kirschning, Carsten Jürgen; Kauth, Marion; Heine, Holger
    Endosomal recognition of Lactococcus lactis G121 and its RNA by dendritic cells is key to its allergy-protective effects
    In: The Journal of Allergy and Clinical Immunology Jg. 139 (2017) Nr. 2, S. 667 - 678.e5
    Online Volltext: dx.doi.org/
  • Gharun, Kourosh; Senges, Julia; Seidl, Maximilian; Lösslein, Anne; Kolter, Julia; Lohrmann, Florens; Fliegauf, Manfred; Elgizouli, Magdeldin; Vavra, Martina; Schachtrup, Kristina; Illert, Anna L; Gilleron, Martine; Kirschning, Carsten Jürgen; Triantafyllopoulou, Antigoni; Henneke, Philipp
    Mycobacteria exploit nitric oxide-induced transformation of macrophages into permissive giant cells
    In: EMBO Reports Jg. 18 (2017) Nr. 12, S. 2144 - 2159
    Online Volltext: dx.doi.org/
  • Makkawi, Hasnaa; Hoch, Shifra; Burns, Elia; Hosur, Kavita; Hajishengallis, George; Kirschning, Carsten Jürgen; Nussbaum, Gabriel
    Porphyromonas gingivalis stimulates TLR2-PI3K signaling to escape immune clearance and induce bone resorption independently of MyD88
    In: Frontiers in Cellular and Infection Microbiology Jg. 7 (2017) S. 359
    Online Volltext: dx.doi.org/ (Open Access)
  • Stein, K.; Jenckel, A.; Brand, S.; Sigmund, A.; Kirschning, Carsten Jürgen; Kauth, M.; Heine, H.
    RNA is the key element of the th1-promoting and allergy-protective activation of dendritic cells by the cowshed bacterium lactococcus lactis G121
    In: Allergy Jg. 72 (2017) Nr. Suppl. 103 SI, S. 93 Abstract 0108
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Ma, Zhiyong; Liu, Jia; Wu, Weimin; Zhang, Ejuan; Zhang, Xiaoyong; Li, Qian; Zelinskyy, Gennadiy; Buer, Jan; Dittmer, Ulf; Kirschning, Carsten Jürgen; Lu, Mengji
    The IL-1R/TLR signaling pathway is essential for efficient CD8+ T-cell responses against hepatitis B virus in the hydrodynamic injection mouse model
    In: Cellular & Molecular Immunology Jg. 14 (2017) Nr. 12, S. 997 - 1008
    Online Volltext: dx.doi.org/ (Open Access)
  • Schick, Judith; Etschel, Philipp; Bailo, Rebeca; Ott, Lisa; Bhatt, Apoorva; Lepenies, Bernd; Kirschning, Carsten Jürgen; Burkovski, Andreas; Lang, Roland
    Toll-like receptor 2 and Mincle cooperatively sense corynebacterial cell wall glycolipids
    In: Infection and Immunity Jg. 85 (2017) Nr. 7, S. e00075 - 17
    Online Volltext: dx.doi.org/ (Open Access)
  • Lehmann, Michael H.; Torres-Domínguez, Lino E.; Price, Philip J. R.; Brandmüller, Christine; Kirschning, Carsten Jürgen; Sutter, Gerd
    CCL2 expression is mediated by type I IFN receptor and recruits NK and T cells to the lung during MVA infection
    In: Journal of Leukocyte Biology (JLB) Jg. 99 (2016) Nr. 6, S. 1057 - 1064
    Online Volltext: dx.doi.org/
  • Maney, Sathish Kumar; Xu, Haifeng C; Huang, Jun; Pandyra, Aleksandra A; Ehlting, Christian; Aguilar-Valenzuela, Renan; Pozdeev, Vitaly I; McIlwain, David R; Zimmermann, Albert; Bode, Johannes G; Hengel, Hartmut; Kirschning, Carsten Jürgen; Kim, Ira R; Hiscott, John; Brenner, Dirk; Häussinger, Dieter; Ohashi, Pamela S; Mak, Tak W; Lang, Karl S.; Lang, Philipp A
    RAIDD Mediates TLR3 and IRF7 Driven Type I Interferon Production
    In: Cellular Physiology and Biochemistry Jg. 39 (2016) Nr. 4, S. 1271 - 1280
    Online Volltext: dx.doi.org/ (Open Access)
  • Kaesler, Susanne; Biedermann, Tilo; Röcken, Martin; Kirschning, Carsten Jürgen; Hartung, Thomas; Hein, Ulrike; Wölbing, Florian; Köberle, Martin; Volz, Thomas; Kempf, Wolfgang E.; Chen, Ko-Ming; Skabytska, Yuliya
    Staphylococcus aureus–derived lipoteichoic acid induces temporary T-cell paralysis independent of Toll-like receptor 2
    In: The Journal of Allergy and Clinical Immunology Jg. 138 (2016) Nr. 3, S. 780 - 790.e6
    Online Volltext: dx.doi.org/
  • Kolter, Julia; Kirschning, Carsten Jürgen; Waskow, Claudia; Goldmann, Tobias; Trieu-Cuot, Patrick; Elling, Roland; Gharun, Kourosh; Spoeri, Evelyne; Feuerstein, Reinhild
    Streptococci Engage TLR13 on Myeloid Cells in a Site-Specific Fashion
    In: The Journal of Immunology (JI) Jg. 196 (2016) Nr. 6, S. 2733 - 2741
    Online Volltext: dx.doi.org/ (Open Access)
  • Castiglia, Virginia; Piersigilli, Alessandra; Ebner, Florian; Janos, Marton; Goldmann, Oliver; Damböck, Ursula; Kröger, Andrea; Weiss, Sigfried; Knapp, Sylvia; Jamieson, Amanda M; Kirschning, Carsten Jürgen; Kalinke, Ulrich; Strobl, Birgit; Müller, Mathias; Stoiber, Dagmar; Lienenklaus, Stefan; Kovarik, Pavel
    Type I Interferon Signaling Prevents IL-1β-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue
    In: Cell Host & Microbe Jg. 19 (2016) Nr. 3, S. 375 - 387
    Online Volltext: dx.doi.org/ (Open Access)
  • Heine, H.; Stein, K.; Jenckel, A.; Brand, S.; Sigmund, A; Holst, O.; Kirschning, Carsten Jürgen; Kauth, M.
    Allergy-protection by the cowshed bacterium Lactococcus lactis G121 involves endosomal acidification and signaling through TLR13 in dendritic cells
    In: Allergy Jg. 70 (2015) Nr. Suppl. 101, S. 52 - 53
    Online Volltext: dx.doi.org/ (Open Access)
  • Krüger, Anne; Oldenburg, Marina; Chebrolu, Chiranjeevi; Beisser, Daniela; Kolter, Julia; Sigmund, Anna M.; Steinmann, Jörg; Schäfer, Simon; Hochrein, Hubertus; Rahmann, Sven; Wagner, Hermann; Henneke, Philipp; Hornung, Veit; Buer, Jan; Kirschning, Carsten Jürgen
    Human TLR8 senses UR/URR motifs in bacterial and mitochondrial RNA
    In: EMBO Reports Jg. 16 (2015) Nr. 12, S. 1656 - 1663
    Online Volltext: dx.doi.org/ (Open Access)
  • Fieber, Christina; Janos, Marton; Koestler, Tina; Gratz, Nina; Li, Xiao-Dong; Castiglia, Virginia; Aberle, Marion; Sauert, Martina; Wegner, Mareike; Alexopoulou, Lena; Kirschning, Carsten Jürgen; Chen, Zhijian J.; Haeseler, Arndt von; Kovarik, Pavel
    Innate immune response to Streptococcus pyogenes depends on the combined activation of TLR13 and TLR2
    In: PLoS ONE Jg. 10 (2015) Nr. 3, S. e0119727
    Online Volltext: dx.doi.org/ (Open Access)
  • Chebrolu, Chiranjeevi; Artner, Daniel; Sigmund, Anna M; Buer, Jan; Zamyatina, Alla; Kirschning, Carsten Jürgen
    Species and mediator specific TLR4 antagonism in primary human and murine immune cells by βGlcN(1 ↔ 1)αGlc based lipid A mimetics
    In: Molecular Immunology Jg. 67 (2015) Nr. 2 B, S. 636 - 641
    Online Volltext: dx.doi.org/
  • Price,, Phillip J. R.; Luckow, Bruno; Torres-Domínguez, Lino E.; Brandmüller, Christine; Zorn, Julia; Kirschning, Carsten Jürgen; Sutter, Gerd; Lehmann, Michael H.
    Chemokine (C-C Motif) Receptor 1 Is Required for Efficient Recruitment of Neutrophils during Respiratory Infection with Modified Vaccinia Virus Ankara
    In: Journal of Virology Jg. 88 (2014) Nr. 18, S. 10840 - 10850
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Dankmeyer, Jennifer L.; Fast, Randy L.; Cote, Christopher K.; Worsham, Patricia L.; Fritz, David; Fisher, Diana; Kern, Steven J.; Merkel, Tod; Kirschning, Carsten Jürgen; Amemiya, Kei
    Multiple roles of Myd88 in the immune response to the plague F1-V vaccine and in protection against an aerosol challenge of Yersinia pestis CO92 in mice
    In: Journal of Immunology Research (2014) S. 341820
    Online Volltext: dx.doi.org/ (Open Access)
  • Volz, Thomas; Skabytska, Yuliya; Guenova, Emmanuella; Chen, Ko-Ming; Frick, Julia-Stefanie; Kirschning, Carsten Jürgen; Kaesler, Susanne; Röcken, Martin; Biedermann, Tilo
    Nonpathogenic bacteria alleviating atopic dermatitis inflammation induce IL-10-producing dendritic cells and regulatory Tr1 cells
    In: Journal of Investigative Dermatology Jg. 134 (2014) Nr. 1, S. 96 - 104
    Online Volltext: dx.doi.org/ (Open Access)
  • Knuschke, Torben; Bayer, Wibke; Rotan, Olga; Sokolova, Viktoriya; Wadwa, Munisch; Kirschning, Carsten Jürgen; Hansen, Wiebke; Sparwasser, T.; Dittmer, Ulf; Epple, Matthias; Buer, Jan; Westendorf, Astrid
    Prophylactic and therapeutic vaccination with a nanoparticle-based peptide vaccine induces efficient protective immunity during acute and chronic retroviral infection
    In: Nanomedicine: Nanotechnology, Biology, and Medicine Jg. 10 (2014) Nr. 8, S. 1787 - 1798
    Online Volltext: dx.doi.org/
  • Hochrein, Hubertus; Kirschning, Carsten Jürgen
    Bacteria evade immune recognition via TLR13 and binding of their 23S rRNA by MLS antibiotics by the same mechanisms
    In: OncoImmunology Jg. 2 (2013) Nr. 3, e23141
    Online Volltext: dx.doi.org/
  • Reimer, Elisa; Somplatzki, Stefan; Zegenhagen, Diana; Hänel, Svenja; Fels, Alina; Bollhorst, Thorsten; Grosse-Hovest, Ludger; Bauer, Stefan; Kirschning, Carsten Jürgen; Böldicke, Thomas
    Molecular cloning and characterization of a novel anti-TLR9 intrabody
    In: Cellular and Molecular Biology Letters Jg. 18 (2013) Nr. 3, S. 433 - 446
    Online Volltext: dx.doi.org/
  • Muntasell, Aura; Costa-Garcia, Marcel; Vera, Andrea; Marina-Garcia, Noemí; Kirschning, Carsten Jürgen; López-Botet, Miguel
    Priming of NK cell anti-viral effector mechanisms by direct recognition of human cytomegalovirus
    In: Frontiers in Immunology Jg. 4 (2013) S. 40
    Online Volltext: dx.doi.org/ (Open Access)
  • Kerur, Nagaraj; Hirano, Yoshio; Tarallo, Valeria; Fowler, Benjamin J.; Bastos-Carvalho, Ana; Yasuma, Tetsuhiro; Yasuma, Reo; Kim, Younghee; Hinton, David R.; Kirschning, Carsten Jürgen; Gelfand, Bradley D.; Ambati, Jayakrishna
    TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy
    In: Investigative Ophthalmology & Visual Science, IOVS Jg. 54 (2013) Nr. 12, S. 7395 - 7401
    Online Volltext: dx.doi.org/
  • Desel, Christiane; Werninghaus, Kerstin; Ritter, Manuel; Jozefowski, Katrin; Wenzel, Jens; Russkamp, Norman; Schleicher, Ulrike; Christensen, Dennis; Wirtz, Stefan; Kirschning, Carsten Jürgen; Agger, Else Marie; Prazeres da Costa, Clarissa; Lang, Roland
    The Mincle-activating adjuvant TDB induces MyD88-dependent Th1 and Th17 responses through IL-1R signaling
    In: PLoS ONE Jg. 8 (2013) Nr. 1, S. e53531
    Online Volltext: dx.doi.org/ (Open Access)
  • Eigenbrod, Tatjana; Franchi, Luigi; Muñoz-Planillo, Raul; Kirschning, Carsten Jürgen; Freudenberg, Marina A.; Núñez, Gabriel; Dalpke, Alexander
    Bacterial RNA mediates activation of caspase-1 and IL-1β release independently of TLRs 3, 7, 9 and TRIF but is dependent on UNC93B
    In: The Journal of Immunology (JI) Jg. 189 (2012) Nr. 1, S. 328 - 336
    Online Volltext: dx.doi.org/
  • Schwandt, Timo; Schumak, Beatrix; Gielen, Gerrit H.; Jüngerkes, Frank; Schmidbauer, Patricia; Klocke, Katrin; Staratschek-Jox, Andrea; Van Rooijen, Niko; Kraal, Georg; Ludwig-Portugall, Isis; Franken, Lars; Wehner, Sven; Kalff, Jörg C.; Weber, Olaf; Kirschning, Carsten Jürgen; Coch, Christoph; Kalinke, Ulrich; Wenzel, Jörg; Kurts, Christian; Zawatzky, Rainer; Holzmann, Bernhard; Layland, Laura; Schultze, Joachim L.; Burgdorf, Sven; Den Haan, Joke M.M.; Knolle, Percy A.; Limmer, Andreas
    Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis
    In: The EMBO Journal Jg. 31 (2012) Nr. 1, S. 201 - 213
    Online Volltext: dx.doi.org/
  • Welsch, Janina; Hübschle, Thomas; Murgott, Jolanta; Kirschning, Carsten Jürgen; Rummel, Christoph; Gerstberger, Rüdiger; Roth, Joachim
    Fever induction by systemic stimulation with macrophage-activating lipopeptide-2 depends upon TLR2 but not CD36
    In: Innate Immunity Jg. 18 (2012) Nr. 3, S. 541 - 559
    Online Volltext: dx.doi.org/
  • Krueger, A.; Oldenburg, M.; Ferstl, R.; Sigmund, A.; Akira, S.; Kawai, T.; Buer, Jan; Wagner, H.; Bauer, Sebastian; Hochrein, H.; Kirschning, Carsten Jürgen
    Neutralization of pathogenic Gram-positive bacteria by macrophages is independent from TLR2,-3,-4,-7, and-9 yet depends upon MyD88
    In: Immunology Jg. 137 (2012) Nr. Suppl. 1, S. 299 - 299
  • Bekeredjian-Ding, Isabelle; Foermer, Sandra; Kirschning, Carsten Jürgen; Parcina, Marijo; Heeg, Klaus
    Poke weed mitogen requires toll-like receptor ligands for proliferative activity in human and murine b lymphocytes
    In: PLoS ONE Jg. 7 (2012) Nr. 1,
    Online Volltext: dx.doi.org/ (Open Access)
  • Gamrekelashvili, Jaba; Ormandy, Lars A.; Heimesaat, Markus M.; Kirschning, Carsten Jürgen; Manns, Michael P.; Korangy, Firouzeh; Greten, Tim F.
    Primary sterile necrotic cells fail to cross-prime CD8⁺ T cells
    In: OncoImmunology Jg. 1 (2012) Nr. 7, S. 1017 - 1026
    Online Volltext: dx.doi.org/
  • Ganal, Stephanie C.; Sanos, Stephanie L.; Kallfass, Carsten; Oberle, Karin; Johner, Caroline; Kirschning, Carsten; Lienenklaus, Stefan; Weiss, Siegfried; Staeheli, Peter; Aichele, Peter; Diefenbach, Andreas
    Priming of Natural Killer Cells by Nonmucosal Mononuclear Phagocytes Requires Instructive Signals from Commensal Microbiota
    In: Immunity Jg. 37 (2012) Nr. 1, S. 171 - 186
    Online Volltext: dx.doi.org/
  • Sigmund, Alexander; Dreher, S.; Wagner, H.; Weitkunat, M.; Kirschning, Carsten Jürgen
    TLR- NOX2 interaction-driven oxidative burst
    In: Immunology Jg. 137 (2012) Nr. Suppl. 1, S. 4 - 4
  • Oldenburg, Marina; Krüger, Anne; Ferstl, Ruth; Kaufmann, Andreas; Nees, Gernot; Sigmund, Anna; Bathke, Barbara; Lauterbach, Henning; Suter, Mark; Dreher, Stefan; Koedel, Uwe; Akira, Shizuo; Kawai, Taro; Buer, Jan; Wagner, Hermann; Bauer, Stefan; Hochrein, Hubertus; Kirschning, Carsten Jürgen
    TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance - Forming modification
    In: Science Jg. 337 (2012) Nr. 6098, S. 1111 - 1115
    Online Volltext: dx.doi.org/
  • Tchaptchet, Sandrine; Gumenscheimer, Marina; Kalis, Christoph; Freudenberg, Nikolaus; Hölscher, Christoph; Kirschning, Carsten Jürgen; Lamers, Marinus; Galanos, Chris; Freudenberg, Marina A.
    TLR9-dependent and independent pathways drive activation of the immune system by propionibacterium acnes
    In: PLoS ONE Jg. 7 (2012) Nr. 6, S. e37155
    Online Volltext: dx.doi.org/ (Open Access)
  • Hanley, Peter J.; Kronlage, Moritz; Kirschning, Carsten Jürgen; Del Rey, Adriana; Di Virgilio, Francesco; Leipziger, Jens; Chessell, Iain P.; Sargin, Sarah; Filippov, Mikhail A.; Lindemann, Otto; Mohr, Simon; Königs, Volker; Schillers, Hermann; Bähler, Martin; Schwab, Albrecht
    Transient P2X 7 receptor activation triggers macrophage death independent of toll-like receptors 2 and 4, caspase-1, and pannexin-1 proteins
    In: The Journal of Biological Chemistry (JBC) Jg. 287 (2012) Nr. 13, S. 10650 - 10663
    Online Volltext: dx.doi.org/
  • Diefenbach, A.; Sanos, S. L.; Kallfass, C.; Kirschning, Carsten Jürgen; Lienenklaus, S.; Weiss, S.; Staeheli, P.; Aichele, P.; Ganal, S. C.
    Type I interferon gene expression by non-mucosal mononuclear phagocytes requires poising by the commensal microbiota
    In: Immunology Jg. 137 (2012) Nr. Suppl. 1, S. 245
  • Yakimchuk, Konstantin; Roura-Mir, Carme; Magalhaes, Kelly G.; De Jong, Annemieke; Kasmar, Anne G.; Granter, Scott R.; Budd, Ralph; Steere, Allen; Pena-Cruz, Victor; Kirschning, Carsten Jürgen; Cheng, Tan-Yun; Moody, D. Branch
    Borrelia burgdorferi infection regulates CD1 expression in human cells and tissues via IL1-β
    In: European Journal of Immunology Jg. 41 (2011) Nr. 3, S. 694 - 705
    Online Volltext: dx.doi.org/ (Open Access)
  • Specht, Sabine; Frank, Jutta K.; Alferink, Judith; Dubben, Bettina; Layland, Laura E.; Denece, Gaelle; Bain, Odile; Förster, Irmgard; Kirschning, Carsten Jürgen; Martin, Coralie; Hoerauf, Achim
    CCL17 Controls Mast Cells for the Defense against Filarial Larval Entry
    In: The Journal of Immunology (JI) Jg. 186 (2011) Nr. 8, S. 4845 - 4852
    Online Volltext: dx.doi.org/
  • Lippmann, Juliane; Müller, Holger C.; Naujoks, Jan; Tabeling, Christoph; Shin, Sunny; Witzenrath, Martin; Hellwig, Katharina; Kirschning, Carsten Jürgen; Taylor, Gregory A.; Barchet, Winfried; Bauer, Stefan; Suttorp, Norbert; Roy, Craig R.; Opitz, Bastian
    Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice
    In: Cellular Microbiology Jg. 13 (2011) Nr. 11, S. 1668 - 1682
    Online Volltext: dx.doi.org/
  • Mersmann, Jan; Habeck, Katharina; Latsch, Kathrina; Zimmermann, René; Jacoby, Christoph; Fischer, Jens W.; Hartmann, Christian; Schrader, Jürgen; Kirschning, Carsten Jürgen; Zacharowski, Kai
    Left ventricular dilation in toll-like receptor 2 deficient mice after myocardial ischemia/reperfusion through defective scar formation
    In: Basic Research in Cardiology Jg. 106 (2011) Nr. 1, S. 89 - 98
    Online Volltext: dx.doi.org/
  • Hoegen, Tobias; Tremel, Nadin; Klein, Matthias; Angele, Barbara; Wagner, Hermann; Kirschning, Carsten Jürgen; Pfister, Hans-Walter; Fontana, Adriano; Hammerschmidt, Sven; Koedel, Uwe
    The NLRP3 Inflammasome Contributes to Brain Injury in Pneumococcal Meningitis and Is Activated through ATP-Dependent Lysosomal Cathepsin B Release
    In: The Journal of Immunology (JI) Jg. 187 (2011) Nr. 10, S. 5440 - 5451
    Online Volltext: dx.doi.org/ (Open Access)
  • Kirschning, Carsten Jürgen; Dreher, Stefan; Maaß, Björn; Fichte, Sylvia; Schade, Jutta; Köster, Mario; Noack, Andreas; Lindenmaier, Werner; Wagner, Hermann; Böldicke, Thomas
    Generation of anti-TLR2 intrabody mediating inhibition of macrophage surface TLR2 expression and TLR2-driven cell activation
    In: BMC Biotechnology Jg. 10 (2010) 31
    Online Volltext: dx.doi.org/ (Open Access)
  • Gibbert, Kathrin; Dietze, Kirsten; Zelinskyy, Gennadiy; Lang, Karl S.; Barchet, Winfried; Kirschning, Carsten Jürgen; Dittmer, Ulf
    Polyinosinic-polycytidylic acid treatment of Friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced disease
    In: The Journal of Immunology (JI) Jg. 185 (2010) Nr. 10, S. 6179 - 6189
    Online Volltext: dx.doi.org/ (Open Access)
  • Wang, Shijun; Schmaderer, Christoph; Kiss, Eva; Schmidt, Claudia; Bonrouhi, Mahnaz; Porubsky, Stefan; Gretz, Norbert; Schaefer, Liliana; Kirschning, Carsten Jürgen; Popovic, Zoran V.; Gröne, Hermann-Josef
    Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88- and TRIF-dependent signaling
    In: Disease Models and Mechanisms (DMM) Jg. 3 (2010) Nr. 1-2, S. 92 - 103
    Online Volltext: dx.doi.org/
  • Mersmann, Jan; Koch, Alexander; Tran, Nguyen; Zimmermann, René; Granja, Tiago F.; Larmann, Jan; Herzog, Christine; Theilmeier, Gregor; Bornstein, Stefan R.; Kirschning, Carsten Jürgen; Zacharowski, Kai
    Toll-like receptor 2 signaling triggers fatal arrhythmias upon myocardial ischemia-reperfusion
    In: Critical Care Medicine Jg. 38 (2010) Nr. 10, S. 1927 - 1932
    Online Volltext: dx.doi.org/
  • Baiersdörfer, Markus; Schwarz, Margarethe; Seehafer, K.; Lehmann, Hans-Joachim; Heit, Antje; Wagner, Hermann; Kirschning, Carsten Jürgen; Koch-Brandt, Claudia
    Toll-like receptor 3 mediates expression of clusterin/apolipoprotein J in vascular smooth muscle cells stimulated with RNA released from necrotic cells
    In: Experimental Cell Research Jg. 316 (2010) Nr. 20, S. 3489 - 3500
    Online Volltext: dx.doi.org/
  • Rusai, Krisztina; Sollinger, Daniel; Baumann, Marcus; Wagner, Bettina; Strobl, Matthias; Schmaderer, Christoph; Roos, Marcel; Kirschning, Carsten Jürgen; Heemann, Uwe; Lutz, Jens
    Toll-like receptors 2 and 4 in renal ischemia/reperfusion injury
    In: Pediatric Nephrology Jg. 25 (2010) Nr. 5, S. 853 - 860
    Online Volltext: dx.doi.org/

    • Abstracts

  • Urbonaviciute, Vilma; Starke, Charlotte; Gräf, Daniela; Mroz, Markus; Kirschning, Carsten; Schett, Georg; Voll, Reinhard E.
    Involvement of toll-like receptor 2 in pristane-induced lupus
    In: Annals of the Rheumatic Diseases (ARD) Jg. 70 (2011) Nr. Suppl. 2, S. A37 - A38
    Online Volltext: dx.doi.org/
  • Urbonaviciute, V.; Fuernrohr, B. G.; Meister, S.; Munoz, L.; Heyder, P.; De Marchis, F.; Bianchi, M. E.; Kirschning, Carsten Jürgen; Wagner, H.; Manfredi, A. A.; Kalden, J. R.; Schett, G.; Rovere-Querini, P.; Herrmann, M.; Voll, R. E.;
    HMGB1 Containing Nucleosomes from Apoptotic Cells Induce Inflammation and Immune Activation via TLR2-Implications for the Etiopathogenesis of Systemic Lupus Erythematosus
    30th European Workshop for Rheumatology Research, 4-7 March 2010, Bamberg, Germany,
    In: Annals of the Rheumatic Diseases (ARD) Jg. 69 (2010) Nr. Suppl. 2, S. A1
    Online Volltext: dx.doi.org/

    • Poster / Posterbeiträge

  • Yang, Xiaoli; Ali, Shafaqat; Richter, Lisa; Schäfer, Vanessa; Schliehe-Diecks, Julian; Frank, Marian; Larsen, Pia-Katharina; Skerra, Jennifer; Islam, Heba; Wachtmeister, Thorsten; Alter, Christina; Bhatia, Sanil; Köhrer, Karl; Kirschning, Carsten Jürgen; Weighardt, Heike; Kalinke, Ulrich; Kalscheuer, Rainer; Uhrberg, Markus; Scheu, Stefanie;
    The mycotoxin Beauvericin exhibits immunostimulatory effects on dendritic cells via activating the TLR4 signaling pathway
    Joint Conference of the Société Française d'Immunologie (SFI) and the Deutsche Gesellschaft für Immunologie (DGfI) ; 26-29 September, 2023, Strasbourg, France,
    In: European Journal of Immunology Jg. 53 (2023) Nr. S2, Special issue: Abstracts: Joint Conference of the Société Française d'Immunologie (SFI) and the Deutsche Gesellschaft für Immunologie (DGfI), 26–29 September, 2023, Strasbourg, France, S. 35
    Online Volltext: dx.doi.org/ (Open Access)