Welcome to ZMB
Welcome to ZMB
The Center of Medical Biotechnology (ZMB) is an interdisciplinary scientific center of the University of Duisburg-Essen, integrating medical research at the University Hospital and natural sciences at the Campus.
News & Events
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New targets for cancer therapies Röntgen Prize for PD Dr. Johann Matschke
Congratulations: The renowned 15,000 euro Röntgen Prize of Justus Liebig University Giessen this year goes to cell biologist PD Dr. Johann Matschke from Essen University Hospital. ZMB member and radiation researcher Johann Matschke receives the prize for his research into the radiation resistance of cancer cells. He has discovered that the defense systems of tumor cells that have become resistant to radiotherapy can be impaired in such a way that the cells are again vulnerable to reactive oxygen radicals and thus to radiation, and hopes to derive new biomarkers for radiation resistance from his findings.
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Mike Blüggel Awarded Joachim Herz Add-on Fellowship
Congratulations to Mike Blüggel on receiving the Joachim Herz Add-on Fellowship for "Innovative Tumor Treatment Project"! His project "Sundowner", explores light-controlled protein degradation using nanobody-PHOTACs in collaboration with UDE´s Faculty of Chemistry. The goal is to combine PHOTACs with nanobodies to enable targeted degradation of the apoptosis inhibitor Survivin in tumor tissue, thereby protecting healthy tissue.
The fellowship enables research stays, conference attendance, training, science communication activities, and participation in fellowship meetings.
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CRC1430 Guest Speaker Series
28.01.2025
Sascha Martens, Vienna BioCenter (VBC), Max Perutz Labs, University of Vienna
18.02.2025
Hana Polasek-Sedlackova, Institute of Biophysics, Czech Academy of Sciences
28.02.2025
Helge Ewers, Institute for Chemistry and Biochemistry, Freie Universität Berlin
Press Releases 2024/2025
![image representing research](/imperia/md/images/pool-ps/inhalt/2025/2025-02-13-selenoprotein-c-tasdogan-lab-1920x1080.jpg)
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Hautkrebs Wie Stress in Krebszellen die Metastasierung hemmen kann
[13.02.2025]
Ein Forschungsteam der Medizinischen Fakultät der Universität Duisburg-Essen hat eine neue Entdeckung gemacht: Das Protein SELENOO aus der Familie der Selenoproteine spielt eine wichtige Rolle bei der Ausbreitung von Krebszellen. Das zeigt das Team in einer neuen Studie, veröffentlicht im Fachjournal Cancer Research.
ZMB Member: Prof. Dr. Alpaslan Tasdogan
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Krebsbehandlung KI verbessert personalisierte Therapie
[31.01.2025]
Maßgeschneiderte, personalierte Medizin basiert bisher auf einer geringen Anzahl an Parametern. Ein Forschungsteam der Medizinischen Fakultät der UDE, der Ludwig-Maximilians-Universität München (LMU) und des Berlin Institute for the Foundations of Learning and Data (BIFOLD) an der Technischen Universität Berlin entwickelt einen neuen Ansatz zur Verbesserung der personalisierten Krebsbehandlung durch Künstliche Intelligenz.
ZMB Member: Prof. Dr. Sebastian Bauer,
Prof. Dr. Dagmar Führer-Sakel,
Prof. Dr. Ken Herrmann,
Prof. Dr. Tienush Rassaf, Prof. Dr. Alexander Roesch, Prof. Dr. Dirk Schadendorf, Prof. Dr. Jens Siveke, Prof. Dr. Martin Schuler
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Chemische Verschmutzung bekämpfen Gewässerreinigung mit Algen
[24.01.2025]
Europas Gewässer sind in schlechtem Zustand: Über die Hälfte von ihnen ist chemisch stark belastet. Kein Wunder – täglich werden in Europa in Industrie und Landwirtschaft bis zu 70.000 verschiedene Chemikalien eingesetzt. Forschende der Universität Duisburg-Essen haben jetzt eine neue Methode entwickelt, um verschmutzte Gewässer zu reinigen. Ihre aktuelle Studie zeigt*, dass fossile Überreste von Kieselalgen (Diatomeen) Schadstoffe effizient aus dem Wasser entfernen können, nachdem sie chemisch modifiziert wurden.
ZMB Member: Prof. Dr. Anzhela Galstyan
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Kooperation mit dem Lawrence Berkeley National Laboratory Algenforschung im Teilchenbeschleuniger
[24.01.2025]
Die Universität Duisburg-Essen beherbergt mit über 7.000 Stämmen die größte Algensammlung der Welt. Nun wird die Sammlung am Teilchenbeschleuniger Advanced Light Source des Lawrence Berkeley National Laboratory mittels Infrarotspektroskopie untersucht. So wollen die Forschenden die chemische Zusammensetzung der Algenzellen entschlüsseln und herausfinden, welche Biomoleküle sie produzieren. Algen stellen beispielsweise Biomoleküle in Form von Lipiden her, die als nachhaltiger Energieträger genutzt werden können.
ZMB Member: Prof. Dr. Alexander Probst
![Kathrin Thedieck portrait](/imperia/md/images/pool-ps/personen/thedieck-kathrin-2024-c-ude-bettina-engel-albustin.jpg)
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UA Ruhr Berufung: Kathrin Thedieck Stoffwechselsignale eröffnen neue Ansätze für Krebsforschung und seltene Erkrankungen
[07.01.2025]
Stress gilt allgemein als ungesund. Wie er sich auf den menschlichen Stoffwechsel auswirkt untersucht Prof. Dr. Kathrin Thedieck, neu berufene Professorin für Metabolismus, Seneszenz und Autophagie an der Fakultät für Medizin der UDE. Dafür forscht sie am Research Center One Health der Universitätsallianz Ruhr zur Kontrolle des Stoffwechsels in Tumorzellen.
ZMB Member: Prof. Dr. Kathrin Thedieck
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Wilhelm Sander-Stiftung fördert Vorhaben Photo-dynamische Liganden für die Onkologie
[06.01.2025]
Ein kleines Protein namens Survivin hilft Tumorzellen dabei, den gängigen Behandlungsmethoden zu entkommen, und sichert so deren Überleben. Die Molekularbiologin Prof. Dr. Shirley Knauer und Chemiker Prof. Dr. Michael Giese von der Universität Duisburg-Essen wollen nun dynamische, durch Licht schaltbare Liganden-Systeme als neuartige Survivin-Inhibitoren entwickeln. Ihr Vorhaben fördert die Wilhelm Sander-Stiftung mit knapp 190.000 Euro für zwei Jahre.
ZMB Member: Prof. Dr. Shirley Knauer
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Oxygen and chlorine evolution without noble metals Electrode potential transforms surfaces
[17.12.2024] They are highly selective and can be easily separated from the reaction mixture: single-atom catalysts combine the advantages of homogeneous and heterogeneous catalysis. Until now, their production has generally been associated with precious metals that are anchored to a solid substrate. Researchers led by the University of Duisburg-Essen have now shown that such structures can also be formed electrochemically – independently and without noble metals. Their findings, published in the scientific journal JACS*, open up new avenues for a simpler, more sustainable production of catalytically active materials.
ZMB Member: Prof. Dr. Kai Exner
10.02.2025 - 11:30:00
Besser kommunizieren: Kostenloses E-Learning-Angebot für ärztlichen Nachwuchs
28.01.2025 - 09:31:11
Neue App reduziert Herz-Kreislauf-Risiko bei Patient:innen mit Herzkrankheiten
ZMB Research Programs
Oncology
The concept of this research program is to understand fundamental processes in tumor biology in order to develop novel molecularly defined and rationally applied cancer treatments.
Participating researchers from biology, experimental and clinical medicine study tumors as “biological systems" and so called “neo-organs”.
A large variety of approaches, experimental systems and methodologies are in place to analyse many aspects of tumor development, growth, progression and tumor cell migration.
Immunology, Infectious Diseases and Transplantation
The immune system responds to various pathogens including viruses and bacteria in different ways to prevent severe disease and persistence in the host. Many pathogens, however, have developed mechanisms to evade immune defence.
The molecular and cellular interactions of pathogens with the immune system are studied within this program.
Molecular and Chemical Cell Biology
Molecular and chemical cell biology is an interdisciplinary research program connecting molecular cell biology and genetics with chemistry and structural biology. Scientists of the participating disciplines collaborate to advance the understanding of basic molecular mechanisms of important biological processes.
The analysis of regulation and deregulation of key pathways is linking basic biology with pathophysiology.
Latest Publications
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Aspartate signalling drives lung metastasis via alternative translationIn: Nature (2025) 15267 in pressOnline Full Text: dx.doi.org/
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Autogene cevumeran with or without atezolizumab in advanced solid tumors: a phase 1 trialIn: Nature Medicine Vol. 31 (2025) Nr. 1, pp. 152 - 164Online Full Text: dx.doi.org/ (Open Access)
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In situ Cyclization of Aromatic Thioethers in Emissive Materials to Generate Phosphorescent DibenzothiophenesIn: Angewandte Chemie International Edition Vol. 64 (2025) Nr. 2, e202414326Online Full Text: dx.doi.org/ (Open Access)
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Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response in pancreatic cancerIn: Nature Communications Vol. 16 (2025) Nr. 1, 335Online Full Text: dx.doi.org/ (Open Access)
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A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanomaIn: Cell Vol. 187 (2024) Nr. 1, pp. 166 - 183.e25Online Full Text: dx.doi.org/ (Open Access)
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A global comparison of surface and subsurface microbiomes reveals large-scale biodiversity gradients, and a marine-terrestrial divideIn: Science Advances Vol. 10 (2024) Nr. 51, eadq0645Online Full Text: dx.doi.org/ (Open Access)
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A modular DNA origami nanocompartment for engineering a cell-free, protein unfolding and degradation pathwayIn: Nature Nanotechnology Vol. 19 (2024) Nr. 10, pp. 1521 - 1531Online Full Text: dx.doi.org/ (Open Access)
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A validation strategy to assess the role of phase separation as a determinant of macromolecular localizationIn: Molecular Cell Vol. 84 (2024) Nr. 9, pp. 1783 - 1801.e7Online Full Text: dx.doi.org/ (Open Access)
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Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054) : Long-term, health-related quality-of-life results from a double-blind, randomised, controlled, phase 3 trialIn: The Lancet Oncology Vol. 25 (2024) Nr. 9, pp. 1202 - 1212Online Full Text: dx.doi.org/
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Alteration of LARGE1 abundance in patients and a mouse model of 5q-associated spinal muscular atrophyIn: Acta Neuropathologica Vol. 147 (2024) Nr. 1, 53Online Full Text: dx.doi.org/ (Open Access)
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Amivantamab plus lazertinib versus osimertinib in first-line EGFR-mutant advanced non-small-cell lung cancer with biomarkers of high-risk disease : a secondary analysis from MARIPOSAIn: Annals of Oncology Vol. 35 (2024) Nr. 9, pp. 805 - 816Online Full Text: dx.doi.org/ (Open Access)
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An atlas of cells in the human tonsilIn: Immunity Vol. 57 (2024) Nr. 2, pp. 379 - 399.e18Online Full Text: dx.doi.org/ (Open Access)
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Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRAIn: Nature Communications Vol. 15 (2024) Nr. 1, 63Online Full Text: dx.doi.org/ (Open Access)
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BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathwayIn: Science Advances Vol. 10 (2024) Nr. 36, eadn9361Online Full Text: dx.doi.org/ (Open Access)
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CCooperative Active Sites on Ag2Pt3TiS6 for Enhanced Low-Temperature Ammonia Fuel Cell ElectrocatalysisIn: Angewandte Chemie International Edition (2024) e202418691 in pressOnline Full Text: dx.doi.org/ (Open Access)
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Cardiac wasting and cancerIn: European Heart Journal Vol. 45 (2024) Nr. 34, pp. 3135 - 3137Online Full Text: dx.doi.org/ (Open Access)
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Cell-mediated cytotoxicity within CSF and brain parenchyma in spinal muscular atrophy unaltered by nusinersen treatmentIn: Nature Communications Vol. 15 (2024) Nr. 1, 4120Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Clinical Benefit of Avapritinib in KIT-Mutant Gastrointestinal Stromal Tumors : A Post Hoc Analysis of the Phase I NAVIGATOR and Phase I/II CS3007-001 StudiesIn: Clinical Cancer Research Vol. 30 (2024) Nr. 4, pp. 719 - 728Online Full Text: dx.doi.org/
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Comparison of pulsed field ablation versus cryoballon and radiofrequency ablation for pulmonary vein isolation in atrial fibrillation patients with heart failureIn: European Heart Journal Vol. 45 (2024) Nr. Supplement_1, ehae666.578Online Full Text: dx.doi.org/ (Open Access)
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Cranioencephalic functional lymphoid units in glioblastomaIn: Nature Medicine Vol. 30 (2024) Nr. 10, pp. 2947 - 2956Online Full Text: dx.doi.org/ (Open Access)
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De novo and salvage purine synthesis pathways across tissues and tumorsIn: Cell Vol. 187 (2024) Nr. 14, pp. 3602 - 3618.e20Online Full Text: dx.doi.org/
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Differential activity of MAPK signalling defines fibroblast subtypes in pancreatic cancerIn: Nature Communications Vol. 15 (2024) Nr. 1, 10534Online Full Text: dx.doi.org/ (Open Access)
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Directionality of HLA-DP permissive mismatches improves risk prediction in HCT for acute leukemia and MDSIn: Blood Vol. 144 (2024) Nr. 16, pp. 1747 - 1751Online Full Text: dx.doi.org/
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Entirely noninvasive outcome prediction in central nervous system lymphomas using circulating tumor DNAIn: Blood Vol. 143 (2024) Nr. 6, pp. 522 - 534Online Full Text: dx.doi.org/
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Evolutionary trajectories of small cell lung cancer under therapyIn: Nature Vol. 627 (2024) Nr. 8005, pp. 880 - 889Online Full Text: dx.doi.org/ (Open Access)
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Final Results for Adjuvant Dabrafenib plus Trametinib in Stage III MelanomaIn: The New England Journal of Medicine Vol. 7 (2024) Nr. 391, pp. 1709 - 1720Online Full Text: dx.doi.org/
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Genetic and functional analyses of CTBP2 in anorexia nervosa and body weight regulationIn: Molecular Psychiatry (2024) in pressOnline Full Text: dx.doi.org/ (Open Access)
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Genomic heterogeneity and ploidy identify patients with intrinsic resistance to PD-1 blockade in metastatic melanomaIn: Science Advances Vol. 10 (2024) Nr. 48, eadp4670Online Full Text: dx.doi.org/ (Open Access)
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Günter Wulff (1935 –2023) : Father of Molecular ImprintingIn: Angewandte Chemie International Edition Vol. 63 (2024) Nr. 12, e202402244Online Full Text: dx.doi.org/ (Open Access)
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HBV shows different levels of adaptation to HLA class I-associated selection pressure correlating with markers of replicationIn: Journal of Hepatology (2024) in pressOnline Full Text: dx.doi.org/ (Open Access)
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Lysosomal damage sensing and lysophagy initiation by SPG20-ITCHIn: Molecular Cell (2024) pp. 1556 - 1569.e10Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Microtubule end-on attachment maturation regulates Mps1 association with its kinetochore receptorIn: Current Biology Vol. 34 (2024) Nr. 11, pp. 2279 - 2293.e6Online Full Text: dx.doi.org/ (Open Access)
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Neoadjuvant nivolumab with or without relatlimab in resectable non-small-cell lung cancer : A randomized phase 2 trialIn: Nature Medicine Vol. 30 (2024) Nr. 6, pp. 1602 - 1611Online Full Text: dx.doi.org/ (Open Access)
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Pathogenic mitochondrial DNA mutations inhibit melanoma metastasisIn: Science Advances Vol. 10 (2024) Nr. 44, eadk8801Online Full Text: dx.doi.org/ (Open Access)
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Rational correction of pathogenic conformational defects in HTRA1In: Nature Communications Vol. 15 (2024) Nr. 1, 5944Online Full Text: dx.doi.org/ (Open Access)
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Regulation of minimal spindle midzone organization by mitotic kinasesIn: Nature Communications Vol. 15 (2024) Nr. 1, 9213Online Full Text: dx.doi.org/ (Open Access)
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Retrotransposons are co-opted to activate hematopoietic stem cells and erythropoiesisIn: Science Vol. 386 (2024) Nr. 6722, eado6836Online Full Text: dx.doi.org/
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Ripretinib versus sunitinib in gastrointestinal stromal tumor : ctDNA biomarker analysis of the phase 3 INTRIGUE trialIn: Nature Medicine Vol. 30 (2024) Nr. 2, pp. 498 - 506Online Full Text: dx.doi.org/ (Open Access)
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Role of protein kinase PLK1 in the epigenetic maintenance of centromeresIn: Science Vol. 385 (2024) Nr. 6713, pp. 1091 - 1097Online Full Text: dx.doi.org/
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Routine extracorporeal life support in infarct-related cardiogenic shock : 1-year results of the ECLS-SHOCK trialIn: European Heart Journal Vol. 45 (2024) Nr. 39, pp. 4200 - 4203Online Full Text: dx.doi.org/ (Open Access)
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Short-term post-fast refeeding enhances intestinal stemness via polyaminesIn: Nature Vol. 633 (2024) Nr. 8031, pp. 895 - 904Online Full Text: dx.doi.org/
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Structure of the human KMN complex and implications for regulation of its assemblyIn: Nature Structural & Molecular Biology Vol. 31 (2024) Nr. 6, pp. 861 - 873Online Full Text: dx.doi.org/ (Open Access)
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Structure-based discovery of first inhibitors targeting the helicase activity of human PIF1In: Nucleic Acids Research Vol. 52 (2024) Nr. 20, pp. 12616 - 12632Online Full Text: dx.doi.org/ (Open Access)
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Subtilase SBT5.2 inactivates flagellin immunogenicity in the plant apoplastIn: Nature Communications Vol. 15 (2024) Nr. 1, 10431Online Full Text: dx.doi.org/ (Open Access)
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T lymphocyte recruitment to melanoma brain tumors depends on distinct venous vesselsIn: Immunity Vol. 57 (2024) Nr. 11, pp. 2688 - 2703.e11Online Full Text: dx.doi.org/ (Open Access)
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The journey to understand previously unknown microbial genesIn: Nature Vol. 626 (2024) Nr. 7998, pp. 267 - 269Online Full Text: dx.doi.org/ (Open Access)
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Thirty years of structural changesIn: Nature Structural & Molecular Biology Vol. 31 (2024) Nr. 1, pp. 4 - 5Online Full Text: dx.doi.org/
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TopBP1 utilises a bipartite GINS binding mode to support genome replicationIn: Nature Communications Vol. 15 (2024) Nr. 1, 1797
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VCF1 is a p97/VCP cofactor promoting recognition of ubiquitylated p97-UFD1-NPL4 substratesIn: Nature Communications Vol. 15 (2024) Nr. 1, 2459Online Full Text: dx.doi.org/ (Open Access)
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Vimseltinib versus placebo for tenosynovial giant cell tumour (MOTION) : a multicentre, randomised, double-blind, placebo-controlled, phase 3 trialIn: Lancet Vol. 403 (2024) Nr. 10445, pp. 2709 - 2719Online Full Text: dx.doi.org/
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XPO1-Mediated mRNA Export of Genome Maintenance Regulators Drives Chemotherapy Resistance in Aggressive LymphomaIn: Cancer Research Vol. 84 (2024) Nr. 1, pp. 3 - 5Online Full Text: dx.doi.org/ (Open Access)
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iSERS : From nanotag design to protein assays and ex vivo imagingIn: Chemical Society Reviews Vol. 53 (2024) Nr. 13, pp. 6675 - 6693Online Full Text: dx.doi.org/ (Open Access)