AG Sutter

Area of Research

During most viral infections, the initial immune response is characterized by the induction of type I interferon (IFN). IFN belongs to a gene family that includes up to 13 different IFN-α subtypes and IFN-β. These interferons all exhibit different biological activities such as antiviral, anti-proliferative and immunomodulatory properties. After their induction, all interferons bind to the same receptor, resulting in the expression of a variety of IFN-stimulated genes that encode antiviral proteins that directly inhibit viral replication as well as modulate immune cell function. Therefore, induction of type I IFN is a powerful tool to combat viral infections. Many viruses have found ways to evade the IFN response. Therefore, the therapeutic administration of exogenous type I IFN should have great potential for future immunotherapies against viral infections. The working group is mainly interested in the different antiviral and immunomodulatory properties of all human and murine IFN-α subtypes in acute and chronic viral infections. Particular attention is paid to the induction of the various subtypes, their regulation and their different biological properties, especially the modulation of immune responses.

PD Dr. rer. nat. Kathrin Sutter

IG1, Room 2.045

Tel. 0201/723-83250

Fax 0201/723-5543

kathrin.sutter@uk-essen.de

Lab Members

​ZehraZehra Karaköse, M.Sc.

PhD Student

Room 2.051

Tel. 02101/723-4224

zehra.karakoese@uk-essen.de

​MaraMara Schwerdtfeger, M.Sc.

PhD Student

Room 2.051

Tel. 0201/723-4050

mara.schwerdtfeger@uk-essen.de

​Sandra FrancoisSandra Francois

Technical Assistant

Room 2.061

Tel. 0201/723-83737

sandra.francois@uk-essen.de

​Thea​Ann Therese Paraguya

Student Assistant

Room 2.061

Tel. 0201/723-4055

AnnTherese.Paraguya@uk-essen.de

​random faceJulia Boesner

Bachelor Student

Raum 2.051

Tel. 0201/723-4050

 

 

Publications

    2024

  • Shahhamzehei, Nasim; Abdelfatah, Sara; Schwarzer-Sperber, Hannah S.; Sutter, Kathrin; Yücer, Rümeysa; Bringmann, Gerhard; Schwarzer, Roland; Efferth, Thomas
    Identification of nitrile-containing isoquinoline-related natural product derivatives as coronavirus entry inhibitors in silico and in vitro
    In: Biomedicine & Pharmacotherapy Vol. 180 (2024) 117517
    Online Full Text: dx.doi.org/ (Open Access)
  • Schreiber, Timm; Koll, Nora; Padberg, Claudia; de los Reyes, Buena; Quinting, Theresa; Malyshkina, Anna; Metzen, Eric; Sutter, Kathrin; Fandrey, Joachim; Winning, Sandra
    Reduced vacuolar ATPase protects mice from Friend virus infection – an unintended but instructive effect in Hif-2afl mice
    In: Journal of Cell Science Vol. 137 (2024) Nr. 12, jcs261893
    Online Full Text: dx.doi.org/
  • Kühn, Daniel; Heinen, Natalie; Sutter, Kathrin; Herrmann, Simon T.; Nocke, Maximilian K.; Todt, Daniel; Burbelo, Peter D.; Steinmann, Eike; Ziehe, Dominik; Koos, Björn; Adamzik, Michael; Putensen, Christian; Zarbock, Alexander; Gravemann, Ute; Jork, Christine; Pfaender, Stephanie
    Divergent autoantibody and cytokine levels in COVID-19 sepsis patients influence survival
    In: Journal of Medical Virology Vol. 96 (2024) Nr. 10, e29935
    Online Full Text: dx.doi.org/ (Open Access)
  • Karakoese, Zehra; Ingola, Martha; Sitek, Barbara; Dittmer, Ulf; Sutter, Kathrin
    IFNα Subtypes in HIV Infection and Immunity
    In: Viruses Vol. 16 (2024) Nr. 3, 364
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Roesmann, Fabian; Sertznig, Helene; Klaassen, Katleen; Wilhelm, Alexander; Heininger, Delia; Heß, Stefanie; Elsner, Carina; Marschalek, Rolf; Santiago, Mario L.; Esser, Stefan; Sutter, Kathrin; Dittmer, Ulf; Widera, Marek
    The interferon-regulated host factor hnRNPA0 modulates HIV-1 production by interference with LTR activity, mRNA trafficking, and programmed ribosomal frameshifting
    In: Journal of Virology Vol. 98 (2024) Nr. 7, e0053424
    Online Full Text: dx.doi.org/
  • Steinbach, Philine; Pastille, Eva; Kaumanns, Lara; Adamczyk, Alexandra; Sutter, Kathrin; Hansen, Wiebke; Dittmer, Ulf; Buer, Jan; Westendorf, Astrid M.; Knuschke, Torben
    Influenza virus infection enhances tumour-specific CD8+ T-cell immunity, facilitating tumour control
    In: PLoS Pathogens Vol. 20 (2024) Nr. 1, e1011982
    Online Full Text: dx.doi.org/ (Open Access)
  • Albanese, Manuel; Chen, Hong-Ru; Gapp, Madeleine; Muenchhoff, Maximilian; Yang, Hsiu-Hui; Peterhoff, David; Hoffmann, Katja; Xiao, Qianhao; Ruhle, Adrian; Ambiel, Ina; Schneider, Stephanie; Mejías-Pérez, Ernesto; Stern, Marcel; Wratil, Paul R.; Hofmann, Katharina; Amann, Laura; Jocham, Linda; Fuchs, Thimo; Ulivi, Alessandro F.; Besson-Girard, Simon; Weidlich, Simon; Schneider, Jochen; Spinner, Christoph D.; Sutter, Kathrin; Dittmer, Ulf; Humpe, Andreas; Baumeister, Philipp; Wieser, Andreas; Rothenfusser, Simon; Bogner, Johannes; Roider, Julia; Knolle, Percy; Hengel, Hartmut; Wagner, Ralf; Laketa, Vibor; Fackler, Oliver T.; Keppler, Oliver T.
    Receptor transfer between immune cells by autoantibody-enhanced, CD32-driven trogocytosis is hijacked by HIV-1 to infect resting CD4 T cells
    In: Cell Reports Medicine Vol. 5 (2024) Nr. 4, 101483
    Online Full Text: dx.doi.org/ (Open Access)

    • 2023

  • Steinbach, Philine; Sutter, Kathrin; Westendorf, Astrid; Buer, Jan; Knuschke, Torben;
    Respiratory but not systemic viral infection induces tumour growth inhibition through CD8+T-cell activation
    Joint Conference of the Société Française d'Immunologie (SFI) and the Deutsche Gesellschaft für Immunologie (DGfI) ; 26-29 September, 2023, Strasbourg, France,
    In: European Journal of Immunology Vol. 53 (2023) Nr. S2, Special issue: Abstracts: Joint Conference of the Société Française d'Immunologie (SFI) and the Deutsche Gesellschaft für Immunologie (DGfI), 26–29 September, 2023, Strasbourg, France, pp. 189
    Online Full Text: dx.doi.org/ (Open Access)
  • Kruth, Carolin; Schwarzer-Sperber, Hannah; Esser, Stefan; Dittmer, Ulf; Schwarzer, Roland; Sutter, Kathrin;
    Effects of type I interferons on HIV latency
    DÖAK 2023 / German-Austrian AIDS Conference, Bonn, Germany, 23-25 March 2023,
    In: HIV Medicine Vol. 24 (2023) Nr. S1, pp. 82
  • Karakoese, Zehra; Schwerdtfeger, Mara; Karsten, Christina; Esser, Stefan; Dittmer, Ulf; Sutter, Kathrin;
    Distinct type I interferon subtypes differentially stimulate T cell responses in HIV1-infected individuals
    DÖAK 2023 / German-Austrian AIDS Conference, Bonn, Germany, 23-25 March 2023,
    In: HIV Medicine Vol. 24 (2023) Nr. 1, pp. 92
  • Schefczyk, Stefan; Luo, Xufeng; Liang, Yaojie; Hasenberg, Mike; Walkenfort, Bernd; Trippler, Martin; Schuhenn, Jonas; Sutter, Kathrin; Lu, Mengji; Wedemeyer, Heiner; Schmidt, Hartmut H.; Broering, Ruth
    Tg1.4HBV-s-rec mice, a crossbred hepatitis B virus-transgenic model, develop mild hepatitis
    In: Scientific Reports Vol. 13 (2023) Nr. 1, 22829
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Malyshkina, Anna; Bayer, Wibke; Podschwadt, Philip; Otto, Lucas; Karakoese, Zehra; Sutter, Kathrin; Bruderek, Kirsten; Wang, Baoxiao; Lavender, Kerry J.; Santiago, Mario L.; Leipe, Pia Madeleine; Elsner, Carina; Esser, Stefan; Brandau, Sven; Gunzer, Matthias; Dittmer, Ulf
    Immunotherapy-induced cytotoxic T follicular helper cells reduce numbers of retrovirus-infected reservoir cells in B cell follicles
    In: PLoS Pathogens Vol. 19 (2023) Nr. 10, e1011725
    Online Full Text: dx.doi.org/ (Open Access)
  • Westmeier, Jaana; Brochtrup, Annika; Paniskaki, Krystallenia; Karakoese, Zehra; Werner, Tanja; Sutter, Kathrin; Dolff, Sebastian; Limmer, Andreas; Mittermüller, Daniela; Liu, Jia; Zheng, Xin; Koval, Tetiana; Kaidashev, Igor; Berger, Marc Moritz; Herbstreit, Frank; Brenner, Thorsten; Witzke, Oliver; Trilling, Mirko; Lu, Mengji; Yang, Dongliang; Babel, Nina; Westhoff, Timm; Dittmer, Ulf; Zelinskyy, Gennadiy
    Macrophage migration inhibitory factor receptor CD74 expression is associated with expansion and differentiation of effector T cells in COVID-19 patients
    In: Frontiers in Immunology Vol. 14 (2023) 1236374
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Li, Ziwei; Xiang, Tiandan; Liang, Boyun; Liu, Jing; Deng, Hui; Yang, Xuecheng; Wang, Hua; Feng, Xuemei; Zelinskyy, Gennadiy; Trilling, Mirko; Sutter, Kathrin; Lu, Mengji; Dittmer, Ulf; Wang, Baoju; Yang, Dongliang; Zheng, Xin; Liu, Jia
    SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection
    In: Virologica Sinica Vol. 38 (2023) Nr. 4, pp. 606 - 619
    Online Full Text: dx.doi.org/ (Open Access)
  • Karakoese, Zehra; Le-Trilling, Vu Thuy Khanh; Schuhenn, Jonas; Francois, Sandra; Lu, Mengji; Liu, Jia; Trilling, Mirko; Hoffmann, Daniel; Dittmer, Ulf; Sutter, Kathrin
    Targeted mutations in IFNα2 improve its antiviral activity against various viruses
    In: mBio Vol. 14 (2023) Nr. 6, e02357-23
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Wang, Qin; Liu, Yanan; Luo, Jinzhuo; Yang, Shangqing; Wang, Lu; Lu, Yinping; Feng, Xuemei; Yang, Xuecheng; Sutter, Kathrin; Dittmer, Ulf; Lu, Mengji; Zheng, Xin; Yang, Dongliang; Liu, Jia
    A systematic comparison reveals dynamic differences in early adaptive immune responses of acute-resolving versus chronic HBV replication
    In: Journal of Medical Virology Vol. 95 (2023) Nr. 3, e28670
    Online Full Text: dx.doi.org/ (Open Access)

    • 2022

  • Xie, Xiaohong; Karakoese, Zehra; Ablikim, Dilhumare; Ickler, Julia; Schuhenn, Jonas; Zeng, Xiaoqing; Feng, Xuemei; Yang, Xuecheng; Dittmer, Ulf; Yang, Dongliang; Sutter, Kathrin; Liu, Jia
    IFNα subtype-specific susceptibility of HBV in the course of chronic infection
    In: Frontiers in Immunology Vol. 13 (2022) 1017753
    Online Full Text: dx.doi.org/ (Open Access)
  • Meister, Toni Luise; Brüggemann, Yannick; Nocke, Maximilian K.; Ulrich, Rainer G.; Schuhenn, Jonas; Sutter, Kathrin; Gömer, André; Bader, Verian; Winklhofer, Konstanze F.; Bröring, Ruth; Verhoye, Lieven; Meuleman, Philip; Vondran, Florian W. R.; Camuzet, Charline; Cocquerel, Laurence; Todt, Daniel; Steinmann, Eike
    A ribavirin-induced ORF2 single-nucleotide variant produces defective hepatitis E virus particles with immune decoy function
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 119 (2022) Nr. 34, e2202653119
    Online Full Text: dx.doi.org/ (Open Access)
  • Wenzek, Christina; Steinbach, Philine; Wirsdörfer, Florian; Sutter, Kathrin; Boehme, Julia D.; Geffers, Robert; Klopfleisch, Robert; Bruder, Dunja; Jendrossek, Verena; Buer, Jan; Westendorf, Astrid; Knuschke, Torben
    CD47 restricts antiviral function of alveolar macrophages during influenza virus infection
    In: iScience Vol. 25 (2022) Nr. 12, 105540
    Online Full Text: dx.doi.org/
  • Schmitz, Yasmin; Schwerdtfeger, Mara; Westmeier, Jaana; Littwitz-Salomon, Elisabeth; Alt, Mira; Brochhagen, Leonie; Krawczyk, Adalbert; Sutter, Kathrin
    Superior antiviral activity of IFNβ in genital HSV-1 infection
    In: Frontiers in Cellular and Infection Microbiology Vol. 12 (2022) 949036
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Schuhenn, Jonas; Meister, Toni Luise; Todt, Daniel; Bracht, Thilo; Schork, Karin; Billaud, Jean-Noel; Elsner, Carina; Heinen, Natalie; Karakoese, Zehra; Haid, Sibylle; Kumar, Sriram; Brunotte, Linda; Eisenacher, Martin; Di, Yunyun; Lew, Jocelyne; Falzarano, Darryl; Chen, Jieliang; Yuan, Zhenghong; Pietschmann, Thomas; Wiegmann, Bettina; Uebner, Hendrik; Taube, Christian; Le-Trilling, Vu Thuy Khanh; Trilling, Mirko; Krawczyk, Adalbert; Ludwig, Stephan; Sitek, Barbara; Steinmann, Eike; Dittmer, Ulf; Lavender, Kerry J.; Sutter, Kathrin; Pfaender, Stephanie
    Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 119 (2022) Nr. 8, e2111600119
    Online Full Text: dx.doi.org/ (Open Access)
  • Rout, Saurav S.; Di, Yunyun; Dittmer, Ulf; Sutter, Kathrin; Lavender, Kerry J.
    Distinct effects of treatment with two different interferon-alpha subtypes on HIV-1-associated T-cell activation and dysfunction in humanized mice
    In: AIDS Vol. 36 (2022) Nr. 3, pp. 325 - 336
    Online Full Text: dx.doi.org/
  • Hussain, Timon; Domnich, Maksim; Bordbari, Sharareh; Pylaeva, Ekaterina; Siakaeva, Elena; Spyra, Ilona; Ozel, Irem; Droege, Freya; Squire, Anthony; Lienenklaus, Stefan; Sutter, Kathrin; Hasenberg, Anja; Gunzer, Matthias; Lang, Stephan; Jablonska, Jadwiga
    IFNAR1 Deficiency Impairs Immunostimulatory Properties of Neutrophils in Tumor-Draining Lymph Nodes
    In: Frontiers in Immunology Vol. 13 (2022)
    Online Full Text: dx.doi.org/ (Open Access)
  • Sertznig, Helene; Roesmann, Fabian; Wilhelm, Alexander; Heininger, Delia; Bleekmann, Barbara; Elsner, Carina; Santiago, Mario; Schuhenn, Jonas; Karakoese, Zehra; Benatzy, Yvonne; Snodgrass, Ryan; Esser, Stefan; Sutter, Kathrin; Dittmer, Ulf; Widera, Marek
    SRSF1 acts as an IFN-I-regulated cellular dependency factor decisively affecting HIV-1 post-integration steps
    In: Frontiers in Immunology Vol. 13 (2022) 935800
    Online Full Text: dx.doi.org/ (Open Access)
  • Sperber, Hannah Sabeth; Sutter, Kathrin; Müller, Karin; Müller, Peter; Schwarzer, Roland
    The Bovine Seminal Plasma Protein PDC-109 Possesses Pan-Antiviral Activity
    In: Viruses Vol. 14 (2022) Nr. 9, 2031
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Karakoese, Zehra; Schwerdtfeger, Mara; Karsten, Christina; Esser, Stefan; Dittmer, Ulf; Sutter, Kathrin
    Distinct Type I Interferon Subtypes Differentially Stimulate T Cell Responses in HIV-1-Infected Individuals
    In: Frontiers in Immunology Vol. 13 (2022) 936918
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Schwerdtfeger, Mara; Dickow, Julia; Schmitz, Yasmin; Francois, Sandra; Karakoese, Zehra; Malyshkina, Anna; Knuschke, Torben; Dittmer, Ulf; Sutter, Kathrin
    Immunotherapy With Interferon α11, But Not Interferon Beta, Controls Persistent Retroviral Infection
    In: Frontiers in Immunology Vol. 12 (2022) 809774
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • David, Paul; Westmeier, Jaana; Drabczyk-Pluta, Malgorzata; Werner, Tanja; Ickler, Julia; Francois, Sandra; Bayer, Wibke; Sutter, Kathrin; Del Rio, Maria Luisa; Rodriguez-Barbosa, Jose-Ignacio; Dittmer, Ulf; Zelinskyy, Gennadiy
    The Role of the Inhibitory Ligand HVEM and Its Receptors CD160 and BTLA in the Regulation of Anti-retroviral T Cell Responses
    In: Frontiers in Virology Vol. 2 (2022) 836291
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)

    • 2021

  • Liu, Jia; Yang, Xuecheng; Wang, Hua; Li, Ziwei; Deng, Hui; Liu, Jing; Xiong, Shue; He, Junyi; Feng, Xuemei; Guo, Chunxia; Wang, Weixian; Zelinskyy, Gennadiy; Trilling, Mirko; Sutter, Kathrin; Senff, Tina; Menne, Christopher; Timm, Jörg; Zhang, Yanfang; Deng, Fei; Lu, Yinping; Wu, Jun; Lu, Mengji; Yang, Dongliang; Dittmer, Ulf; Wang, Baoju; Zheng, Xin
    Analysis of the long-term impact on cellular immunity in COVID-19-recovered individuals reveals a profound nkt cell impairment
    In: mBio Vol. 12 (2021) Nr. 2, pp. e00085 - 21
    Online Full Text: dx.doi.org/ (Open Access)
  • Wienhöfer, Lisa; Marker, Max; Antoni, Anne-Charlotte; Sutter, Kathrin; Sander, André; Dudda, Marcel; Flohe, Stefanie
    TLR4 Transactivates CD8⁺ T Lymphocytes upon Acute Sterile Tissue Injury
    In: ImmunoHorizons Vol. 5 (2021) Nr. 5, pp. 298 - 306
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Li, Ziwei; Xiang, Tiandan; Liang, Boyun; Deng, Hui; Wang, Hua; Feng, Xuemei; Quan, Xufeng; Wang, Xiaoyan; Li, Sumeng; Lu, Sihong; Yang, Xuecheng; Wang, Baoju; Zelinskyy, Gennadiy; Trilling, Mirko; Sutter, Kathrin; Lu, Mengji; Dittmer, Ulf; Yang, Dongliang; Zheng, Xin; Liu, Jia
    Characterization of SARS-CoV-2-Specific Humoral and Cellular Immune Responses Induced by Inactivated COVID-19 Vaccines in a Real-World Setting
    In: Frontiers in Immunology Vol. 12 (2021) 802858
    Online Full Text: dx.doi.org/ (Open Access)
  • Chen, Jieliang; Li, Yaming; Lai, Fritz; Wang, Yang; Sutter, Kathrin; Dittmer, Ulf; Ye, Jianyu; Zai, Wenjing; Liu, Min; Shen, Fang; Wu, Min; Hu, Kongying; Li, Baocun; Lu, Mengji; Zhang, Xiaonan; Zhang, Jiming; Li, Jianhua; Chen, Qingfeng; Yuan, Zhenghong
    Functional Comparison of Interferon-α Subtypes Reveals Potent Hepatitis B Virus Suppression by a Concerted Action of Interferon-α and Interferon-γ Signaling
    In: Hepatology Vol. 73 (2021) Nr. 2, pp. 486 - 502
    Online Full Text: dx.doi.org/
  • Xiong, Shue; Zhu, Dan; Liang, Boyun; Li, Mingyue; Pan, Wen; He, Junyi; Wang, Hua; Sutter, Kathrin; Dittmer, Ulf; Lu, Mengji; Liu, Di; Yang, Dongliang; Liu, Jia; Zheng, Xin
    Longitudinal characterization of phenotypic profile of T cells in chronic hepatitis B identifies immune markers associated with HBsAg loss
    In: EBioMedicine Vol. 69 (2021) 103464
    Online Full Text: dx.doi.org/ (Open Access)

    • 2020

  • Wang, Shichuan; Trilling, Mirko; Sutter, Kathrin; Dittmer, Ulf; Lu, Mengji; Zheng, Xin; Yang, Dongliang; Liu, Jia
    A Crowned Killer’s Résumé : Genome, Structure, Receptors, and Origin of SARS-CoV-2
    In: Virologica Sinica (2020)
    Online Full Text: dx.doi.org/ (Open Access)
  • Sutter, Kathrin
    Die Einmischer: Interferone : Wie sie die Immunantwort beeinflussen, um Viren effektiv zu bekämpfen
    In: Unikate: Berichte aus Forschung und Lehre (2020) Nr. 54: Medizin: Infektionskrankheiten - ein globales Problem, pp. 18 - 27
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Liu, Jia; Zheng, Xin; Tong, Qiaoxia; Li, Wei; Wang, Baoju; Sutter, Kathrin; Trilling, Mirko; Lu, Mengji; Dittmer, Ulf; Yang, Dongliang
    Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV
    In: Journal of Medical Virology Vol. 92 (2020) Nr. 5, pp. 491 - 494
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Guo, Kejun; Shen, Guannan; Kibbie, Jon; Gonzalez, Tania; Dillon, Stephanie M.; Smith, Harry A.; Cooper, Emily H.; Lavender, Kerry; Hasenkrug, Kim J.; Sutter, Kathrin; Dittmer, Ulf; Kroehl, Miranda; Kechris, Katerina; Wilson, Cara C.; Santiago, Mario L.
    Qualitative differences between the IFNα subtypes and IFNβ influence chronic mucosal HIV-1 pathogenesis
    In: PLoS Pathogens Vol. 16 (2020) Nr. 10, pp. 1008986
    Online Full Text: dx.doi.org/ (Open Access)
  • Heilingloh, Christiane Silke; Aufderhorst, Ulrich Wilhelm; Schipper, Leonie; Dittmer, Ulf; Witzke, Oliver; Yang, Dongliang; Zheng, Xin; Sutter, Kathrin; Trilling, Mirko; Alt, Mira; Steinmann, Eike; Krawczyk, Adalbert
    Susceptibility of SARS-CoV-2 to UV irradiation
    In: American Journal of Infection Control Vol. 48 (2020) Nr. 10, pp. 1273 - 1275
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Westmeier, Jaana; Paniskaki, Krystallenia; Karaköse, Zehra; Werner, Tanja; Sutter, Kathrin; Dolff, Sebastian; Overbeck, Marvin; Limmer, Andreas; Liu, Jia; Zheng, Xin; Brenner, Thorsten; Berger, Marc; Witzke, Oliver; Trilling, Mirko; Lu, Mengji; Yang, Dongliang; Babel, Nina; Westhoff, Timm; Dittmer, Ulf; Zelinskyy, Gennadiy
    Erratum for Westmeier et al., "Impaired Cytotoxic CD8⁺ T Cell Response in Elderly COVID-19 Patients"
    In: mBio Vol. 11 (2020) Nr. 5, pp. 02243 - 02220
    Online Full Text: dx.doi.org/ (Open Access)
  • Ickler, Julia; Francois, Sandra; Widera, Marek; Santiago, Mario L.; Dittmer, Ulf; Sutter, Kathrin
    HIV infection does not alter interferon α/β receptor 2 expression on mucosal immune cells
    In: PLoS ONE Vol. 15 (2020) Nr. 1, pp. e0218905
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Westmeier, Jaana; Paniskaki, Krystallenia; Karaköse, Zehra; Werner, Tanja; Sutter, Kathrin; Dolff, Sebastian; Overbeck, Marvin; Limmer, Andreas; Liu, Jia; Zheng, Xin; Brenner, Thorsten; Berger, Marc; Witzke, Oliver; Trilling, Mirko; Lu, Mengji; Yang, Dongliang; Babel, Nina; Westhoff, Timm; Dittmer, Ulf; Zelinskyy, Gennadiy
    Impaired cytotoxic CD8⁺ T cell response in elderly COVID-19 patients
    In: mBio Vol. 11 (2020) Nr. 5, pp. e02243 - 20
    Online Full Text: dx.doi.org/ (Open Access)
  • Zutz, Ariane; Schölz, Christian; Schneider, Stephanie; Pierini, Virginia; Münchhoff, Maximilian; Sutter, Kathrin; Wittmann, Georg; Dittmer, Ulf; Draenert, Rika; Bogner, Johannes R.; Fackler, Oliver T.; Keppler, Oliver T.
    SERINC5 Is an Unconventional HIV Restriction Factor That Is Upregulated during Myeloid Cell Differentiation
    In: Journal of Innate Immunity Vol. 12 (2020) Nr. 5, pp. 399 - 409
    Online Full Text: dx.doi.org/ (Open Access)

    • 2019

  • Sutter, Kathrin; Lavender, Kerry J.; Messer, Ronald J.; Widera, Marek; Williams, Katie; Race, Brent; Hasenkrug, Kim J.; Dittmer, Ulf
    Concurrent administration of IFNα14 and cART in TKO-BLT mice enhances suppression of HIV-1 viremia but does not eliminate the latent reservoir
    In: Scientific Reports Vol. 9 (2019) pp. 18089
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Dickow, Julia; Francois, Sandra; Kaiserling, Rouven-Luca; Malyshkina, Anna; Drexler, Ingo; Westendorf, Astrid Maria; Lang, Karl Sebastian; Santiago, Mario L.; Dittmer, Ulf; Sutter, Kathrin
    Diverse immunomodulatory effects of individual IFNα subtypes on virus-specific CD8⁺ T cell responses
    In: Frontiers in Immunology Vol. 10 (2019) 2255
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Matos, Aline da Rocha; Wunderlich, Katharina; Schloer, Sebastian; Schughart, Klaus; Geffers, Robert; Seders, Martine; Witt, Marlous de; Christersson, Anmari; Wiewrodt, Rainer; Wiebe, Karsten; Barth, Peter; Hocke, Andreas; Hippenstiel, Stefan; Hönzke, Katja; Dittmer, Ulf; Sutter, Kathrin; Rescher, Ursula; Rodionycheva, Svetlana; Matera, Nicoletta; Ludwig, Stephan; Brunotte, Linda
    Antiviral potential of human IFN-α subtypes against influenza A H3N2 infection in human lung explants reveals subtype-specific activities
    In: Emerging Microbes & Infections Vol. 8 (2019) Nr. 1, pp. 1763 - 1776
    Online Full Text: dx.doi.org/ (Open Access)
  • Passos, Vânia; Zillinger, Thomas; Casartelli, Nicoletta; Wachs, Amelie S.; Xu, Shuting; Malassa, Angelina; Steppich, Katja; Schilling, Hildegard; Franz, Sergej; Todt, Daniel; Steinmann, Eike; Sutter, Kathrin; Dittmer, Ulf; Bohne, Jens; Schwartz, Olivier; Barchet, Winfried; Goffinet, Christine
    Characterization of Endogenous SERINC5 Protein as Anti-HIV-1 Factor
    In: Journal of Virology Vol. 93 (2019) Nr. 24, pp. e01221 - 19
    Online Full Text: dx.doi.org/ (Open Access)
  • Hasenkrug, Kim J.; Lavender, Kerry J.; Santiago, Mario L.; Sutter, Kathrin; Dittmer, Ulf
    Different Biological Activities of Specific Interferon Alpha Subtypes
    In: mSphere Vol. 4 (2019) Nr. 4, e00127 - 19
    Online Full Text: dx.doi.org/ (Open Access)
  • Malyshkina, Anna; Littwitz-Salomon, Elisabeth; Sutter, Kathrin; Ross, Jean Alexander; Paschen, Annette; Windmann, Sonja; Schimmer, Simone; Dittmer, Ulf
    Chronic retroviral infection of mice promotes tumor development, but CD137 agonist therapy restores effective tumor immune surveillance
    In: Cancer Immunology, Immunotherapy Vol. 68 (2019) Nr. 3, pp. 479 - 488
    Online Full Text: dx.doi.org/
  • Dittmer, Ulf; Sutter, Kathrin; Kassiotis, George; Zelinskyy, Gennadiy; Bánki, Zoltán; Stoiber, Heribert; Santiago, Mario L.; Hasenkrug, Kim J.
    Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity
    In: FEMS Microbiology Reviews Vol. 43 (2019) Nr. 5, pp. 435 - 456
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Gujer, Cornelia; Murer, Anita; Müller, Anne; Vanoaica, Danusia; Sutter, Kathrin; Jacque, Emilie; Fournier, Nathalie; Kalchschmidt, Jens; Zbinden, Andrea; Capaul, Riccarda; Dzionek, Andrzej; Mondon, Philippe; Dittmer, Ulf; Münz, Christian
    Plasmacytoid dendritic cells respond to Epstein-Barr virus infection with a distinct type I interferon subtype profile
    In: Blood Advances Vol. 3 (2019) Nr. 7, pp. 1129 - 1144
    Online Full Text: dx.doi.org/ (Open Access)
  • Braun, Elisabeth; Hotter, Dominik; Koepke, Lennart; Zech, Fabian; Groß, Rüdiger; Sparrer, Konstantin M.J.; Müller, Janis A.; Pfaller, Christian K.; Heusinger, Elena; Wombacher, Rebecka; Sutter, Kathrin; Dittmer, Ulf; Winkler, Michael; Simmons, Graham; Jakobsen, Martin R.; Conzelmann, Karl-Klaus; Pöhlmann, Stefan; Münch, Jan; Fackler, Oliver T.; Kirchhoff, Frank; Sauter, Daniel
    Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins
    In: Cell Reports Vol. 27 (2019) Nr. 7, pp. 2092 - 2104.e10
    Online Full Text: dx.doi.org/ (Open Access)
  • Xia, Yuchen; Schlapschy, Martin; Morath, Volker; Roeder, Natalie; Vogt, Elisabeth I.; Stadler, Daniela; Cheng, Xiaoming; Dittmer, Ulf; Sutter, Kathrin; Heikenwalder, Mathias; Skerra, Arne; Protzer, Ulrike
    PASylated interferon α efficiently suppresses hepatitis B virus and induces anti-HBs seroconversion in HBV-transgenic mice
    In: Antiviral Research Vol. 161 (2019) pp. 134 - 143
    Online Full Text: dx.doi.org/

    • 2018

  • Shen, Fang; Li, Yaming; Wang, Yang; Sozzi, Vitina; Revill, Peter A.; Liu, Jiangxia; Gao, Lu; Yang, Guang; Lu, Mengji; Sutter, Kathrin; Dittmer, Ulf; Chen, Jieliang; Yuan, Zhenghong
    Hepatitis B virus sensitivity to interferon-α in hepatocytes is more associated with cellular interferon response than with viral genotype
    In: Hepatology Vol. 67 (2018) Nr. 4, pp. 1237 - 1252
    Online Full Text: dx.doi.org/ (Open Access)
  • Lavender, Kerry J.; Pace, Craig; Sutter, Kathrin; Messer, Ronald J.; Pouncey, Dakota L.; Cummins, Nathan W.; Natesampillai, Sekar; Zheng, Jim; Goldsmith, Joshua; Widera, Marek; Van Dis, Erik S.; Phillips, Katie; Race, Brent; Dittmer, Ulf; Kukolj, George; Hasenkrug, Kim J.
    An advanced BLT-humanized mouse model for extended HIV-1 cure studies
    In: AIDS Vol. 32 (2018) Nr. 1, pp. 1 - 10
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Korth, Johannes; Anastasiou, Olympia E.; Verheyen, Jens; Dickow, Julia; Sertznig, Helene; Frericks, Nicola; Bleekmann, Barbara; Kribben, Andreas; Brinkhoff, Alexandra; Wilde, Benjamin; Sutter, Kathrin; Dittmer, Ulf; Ciesek, Sandra; Witzke, Oliver; Widera, Marek
    Impact of immune suppressive agents on the BK-Polyomavirus non coding control region
    In: Antiviral Research Vol. 159 (2018) pp. 68 - 76
    Online Full Text: dx.doi.org/
  • Knuschke, Torben; Rotan, Olga; Bayer, Wibke; Kollenda, Sebastian; Dickow, Julia; Sutter, Kathrin; Hansen, Wiebke; Dittmer, Ulf; Lang, Karl S.; Epple, Matthias; Buer, Jan; Westendorf, Astrid
    Induction of Type I Interferons by Therapeutic Nanoparticle-Based Vaccination Is Indispensable to Reinforce Cytotoxic CD8+ T Cell Responses During Chronic Retroviral Infection
    In: Frontiers in Immunology Vol. 9 (2018) 614
    Online Full Text: dx.doi.org/ (Open Access)
  • Sutter, Kathrin; Dickow, Julia; Dittmer, Ulf
    Interferon α subtypes in HIV infection
    In: Cytokine & Growth Factor Reviews Vol. 40 (2018) pp. 13 - 18
    Online Full Text: dx.doi.org/

    • 2017

  • Li, Yanpeng; Sun, Binlian; Esser, Stefan; Jessen, Heiko; Streeck, Hendrik; Widera, Marek; Yang, Rongge; Dittmer, Ulf; Sutter, Kathrin
    Expression pattern of individual IFNA subtypes in chronic HIV infection
    In: Journal of Interferon & Cytokine Research Vol. 37 (2017) Nr. 12, pp. 541 - 549
    Online Full Text: dx.doi.org/
  • Zhou, Yun; Li, Sheng; Tang, Zongsheng; Xu, Chunli; Huang, Shunmei; Wu, Jun; Dittmer, Ulf; Dickow, Julia; Sutter, Kathrin; Lu, Mengji; Yang, Dongliang; Song, Jingjiao
    Different antiviral effects of IFNα and IFNβ in an HBV mouse model
    In: Immunobiology Vol. 222 (2017) Nr. 3, pp. 562 - 570
    Online Full Text: dx.doi.org/
  • Ziegler, Susanne M.; Beisel, Claudia; Sutter, Kathrin; Griesbeck, Morgane; Hildebrandt, Heike; Hagen, Sven H.; Dittmer, Ulf; Altfeld, Marcus
    Human pDCs display sex-specific differences in type I interferon subtypes and interferon α/β receptor expression
    In: European Journal of Immunology Vol. 47 (2017) Nr. 2, pp. 251 - 256
    Online Full Text: dx.doi.org/
  • Song, Jingjiao; Li, Sheng; Zhou, Yun; Liu, Jia; Francois, Sandra; Lu, Mengji; Yang, Dongliang; Dittmer, Ulf; Sutter, Kathrin
    Different antiviral effects of IFNα subtypes in a mouse model of HBV infection
    In: Scientific Reports Vol. 7 (2017) Nr. 1, pp. 334
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Malyshkina, Anna; Littwitz-Salomon, Elisabeth; Sutter, Kathrin; Zelinskyy, Gennadiy; Windmann, Sonja; Schimmer, Simone; Paschen, Annette; Streeck, Hendrik; Hasenkrug, Kim J; Dittmer, Ulf
    Fas Ligand-mediated cytotoxicity of CD4+ T cells during chronic retrovirus infection
    In: Scientific Reports Vol. 7 (2017) pp. 7785
    Online Full Text: dx.doi.org/ (Open Access)
  • Schreiber, Timm; Quinting, Theresa; Dittmer, Ulf; Fandrey, Joachim; Sutter, Kathrin
    Hypoxia-inducible factor 1α is essential for macrophage-mediated erythroblast proliferation in acute friend retrovirus infection
    In: Scientific Reports Vol. 7 (2017) art. no. 17236
    Online Full Text: dx.doi.org/ (Open Access)

    • 2016

  • Littwitz-Salomon, Elisabeth; Dittmer, Ulf; Sutter, Kathrin
    Insufficient natural killer cell responses against retroviruses : How to improve NK cell killing of retrovirus-infected cells
    In: Retrovirology Vol. 13 (2016) Nr. 1, 77
    Online Full Text: dx.doi.org/ (Open Access)
  • Lavender, Kerry J.; Gibbert, Kathrin; Peterson, Karin E.; Van Dis, Erik; Francois, Sandra; Woods, Tyson; Messer, Ronald J.; Gawanbacht, Ali; Müller, Janis A.; Münch, Jan; Phillips, Katie; Race, Brent; Harper, Michael S.; Guo, Kejun; Lee, Eric J.; Trilling, Mirko; Hengel, Hartmut; Piehler, Jacob; Verheyen, Jens; Wilson, Cara C.; Santiago, Mario L.; Hasenkrug, Kim J.; Dittmer, Ulf
    Interferon alpha subtype-specific suppression of HIV-1 infection in vivo
    In: Journal of Virology Vol. 90 (2016) Nr. 13, pp. 6001 - 6013
    Online Full Text: dx.doi.org/ (Open Access)
  • Blömker, Dominique; Mollérus, Sina; Gibbert, Kathrin; Dittmer, Ulf; Del Rey, Adriana E.; Schedlowski, Manfred; Engler, Harald
    Inhibition of catecholamine degradation ameliorates while chemical sympathectomy aggravates the severity of acute Friend retrovirus infection in mice
    In: Brain, Behavior and Immunity Vol. 54 (2016) pp. 252 - 259
    Online Full Text: dx.doi.org/

    • 2015

  • Harper, Michael S.; Guo, Kejun; Gibbert, Kathrin; Lee, Eric J.; Dillon, Stephanie M.; Barrett, Bradley S.; McCarter, Martin D.; Hasenkrug, Kim J.; Dittmer, Ulf; Wilson, Cara C.; Santiago, Mario L.
    Interferon-α subtypes in an ex vivo model of acute HIV-1 infection : expression, potency and effector mechanisms
    In: PLoS Pathogens Vol. 11 (2015) Nr. 11, pp. e1005254
    Online Full Text: dx.doi.org/ (Open Access)
  • Littwitz-Salomon, Elisabeth; Akhmetzyanova, Ilseyar; Vallet, Cecilia; Francois, Sandra; Dittmer, Ulf; Gibbert, Kathrin
    Activated regulatory T cells suppress effector NK cell responses by an IL-2-mediated mechanism during an acute retroviral infection
    In: Retrovirology Vol. 12 (2015) Nr. 1, 66
    Online Full Text: dx.doi.org/ (Open Access)
  • Wu, Weimin; Dietze, Kirsten; Gibbert, Kathrin; Lang, Karl S.; Trilling, Mirko; Yan, Huimin; Wu, Jun; Yang, Dongliang; Lu, Mengji; Roggendorf, Michael; Dittmer, Ulf; Liu, Jia
    TLR ligand induced IL-6 counter-regulates the anti-viral CD8+ T cell response during an acute retrovirus infection
    In: Scientific Reports Vol. 5 (2015) pp. 10501
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)

    • 2014

  • Bröring, Ruth; Real, Catherine; John, Matthias J.; Jahn-Hofmann, Kerstin; Ickenstein, Ludger M.; Kleinehr, Kathrin; Paul, Andreas; Sutter, Kathrin; Dittmer, Ulf; Gerken, Guido; Schlaak, Jörg Friedrich
    Chemical modifications on siRNAs avoid Toll-like-receptor-mediated activation of the hepatic immune system in vivo and in vitro
    In: International Immunology Vol. 26 (2014) Nr. 1, pp. 35 - 46
    Online Full Text: dx.doi.org/

    • 2013

  • Gibbert, K.; Schlaak, Jörg Friedrich; Yang, D.; Dittmer, Ulf; Schlaak, JF
    IFN-α subtypes : Distinct biological activities in anti-viral therapy
    In: British Journal of Pharmacology (BJP) Vol. 168 (2013) Nr. 5, pp. 1048 - 1058
    Online Full Text: dx.doi.org/ (Open Access)
  • Littwitz-Salomon, Elisabeth; Francois, Sandra; Dittmer, Ulf; Gibbert, Kathrin
    Distinct roles of NK cells in viral immunity during different phases of acute Friend retrovirus infection
    In: Retrovirology Vol. 10 (2013) Nr. 1, 127
    Online Full Text: dx.doi.org/ (Open Access)
  • Harper, Michael S.; Barrett, Bradley S.; Smith, Diana S.; Li, Sam X.; Gibbert, Kathrin; Dittmer, Ulf; Hasenkrug, Kim J.; Santiago, Mario L.
    IFN-α treatment inhibits acute friend retrovirus replication primarily through the antiviral effector molecule Apobec3
    In: The Journal of Immunology (JI) Vol. 190 (2013) Nr. 4, pp. 1583 - 1590
    Online Full Text: dx.doi.org/
  • Behrendt, Rayk; Schumann, Tina; Gerbaulet, Alexander; Nguyen, Laura A.; Schubert, Nadja; Alexopoulou, Dimitra; Berka, Ursula; Lienenklaus, Stefan; Peschke, Katrin; Gibbert, Kathrin; Wittmann, Sabine; Lindemann, Dirk; Weiss, Siegfried; Dahl, Andreas; Naumann, Ronald; Dittmer, Ulf; Kim, Baek; Mueller, Werner; Gramberg, Thomas; Roers, Axel
    Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response
    In: Cell Reports Vol. 4 (2013) Nr. 4, pp. 689 - 696
    Online Full Text: dx.doi.org/ (Open Access)
  • Wobben, Regina; Hüsecken, Yvonne; Lodewick, Claudia; Gibbert, Kathrin; Fandrey, Joachim; Winning, Sandra
    Role of hypoxia inducible factor-1 α for interferon synthesis in mouse dendritic cells
    In: Biological Chemistry Vol. 394 (2013) Nr. 4, pp. 495 - 505
    Online Full Text: dx.doi.org/

    • 2012

  • Gibbert, Kathrin; Joedicke, Jara J.; Meryk, Andreas; Trilling, Mirko; Francois, Sandra; Duppach, Janine; Kraft, Anke; Lang, Karl S.; Dittmer, Ulf
    Interferon-alpha Subtype 11 Activates NK Cells and Enables Control of Retroviral Infection
    In: PLoS Pathogens Vol. 8 (2012) Nr. 8, pp. e1002868
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)

    • 2011

  • Gibbert, Kathrin; Dittmer, Ulf
    Distinct antiviral activities of IFN-α subtypes
    In: Immunotherapy Vol. 3 (2011) Nr. 7, pp. 813 - 816
    Online Full Text: dx.doi.org/
  • Zelinskyy, Gennadiy; Myers, Lara; Dietze, Kirsten; Gibbert, Kathrin; Roggendorf, Michael; Liu, Jia; Lu, Mengji; Kraft, Anke R.; Teichgräber, Volker; Hasenkrug, Kim J.; Dittmer, Ulf
    Virus-Specific CD8+ T Cells Upregulate Programmed Death-1 Expression during Acute Friend Retrovirus Infection but Are Highly Cytotoxic and Control Virus Replication
    In: The Journal of Immunology (JI) Vol. 187 (2011) Nr. 7, pp. 3730 - 3737
    Online Full Text: dx.doi.org/
  • Dietze, Kirsten; Zelinskyy, Gennadiy; Gibbert, Kathrin; Schimmer, Simone; Francois, Sandra; Myers, Lara; Sparwasser, Tim; Hasenkrug, Kim J.; Dittmer, Ulf
    Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8⁺ T cells and reduces chronic retroviral set points
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 108 (2011) Nr. 6, pp. 2420 - 2425
    Online Full Text: dx.doi.org/ (Open Access)

    • 2010

  • Sender, Linda Y.; Gibbert, Kathrin; Suezer, Yasemin; Radeke, Heinfried H.; Kalinke, Ulrich; Waibler, Zoe
    CD40 ligand-triggered human dendritic cells mount interleukin-23 responses that are further enhanced by danger signals
    In: Molecular Immunology Vol. 47 (2010) Nr. 6, pp. 1255 - 1261
    Online Full Text: dx.doi.org/
  • Gibbert, Kathrin; Dietze, Kirsten; Zelinskyy, Gennadiy; Lang, Karl S.; Barchet, Winfried; Kirschning, Carsten Jürgen; Dittmer, Ulf
    Polyinosinic-polycytidylic acid treatment of Friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced disease
    In: The Journal of Immunology (JI) Vol. 185 (2010) Nr. 10, pp. 6179 - 6189
    Online Full Text: dx.doi.org/ (Open Access)