News
June 2024 ISHR Europen Section / Toulouse 2024
Chantal Eickelmann received the "ISHR-ES Travel Award" at the congress of the International Society for Heart Research (ISHR) in Toulouse, France.
During the cardioprotection session, she presented our unpublished data on the cardiac mitochondrial proteome in Ossabaw miniature pigs. This animal model is characterized by a polygenic predisposition to metabolic syndrome.
June 2024 Activation of the non-neuronal cholinergic cardiac system by hypoxic preconditioning protects isolated adult cardiomyocytes from hypoxia/reoxygenation injury
Braczko F, Fischl SR, Reinders J, Lieder H, Kleinbongard P
Am J Physiol Heart Circ Physiol 10.1152/ajpheart.00211.2024
June 2014 Vago-splenic signal transduction of cardioprotection in humans
Lieder HR, Paket U, Skyschally A, Rink AD, Baars T, Neuhäuser M, Kleinbongard P, Heusch G
Vago-splenic signal transduction of cardioprotection in humans. Eur Heart J; 6:ehae250
April 2024 Symposium "Koronare Herzkrankheit - ein update"
Coronary heart disease continues to affect many people in Germany and, with its complications such as heart attack, arrhythmias, and heart failure, remains one of the leading causes of death. On April 23, 2024, the North Rhine-Westphalian Academy of Sciences and Arts held a public expert symposium to inform about fundamental new scientific findings in the prevention, diagnosis, therapy, and research of coronary heart disease.
April 2024 APS SUMMIT 2024
Chantal Eickelmann received the "International Early-Career Physiologist (IECP) Travel Award" at the American Physiological Society (APS) "SUMMIT 2024" congress in Long Beach, USA. During the poster presentations, she presented our recently published data on vascular function in Ossabaw miniature pigs. This animal model is characterized by a polygenic predisposition to metabolic syndrome.
April 2024 “Expression of concern”: publication bias for positive preclinical cardioprotection studies
Skyschally, A., Kleinbongard, P., Neuhäuser, M., Heusch, G. “Expression of concern”: publication bias for positive preclinical cardioprotection studies. Basic Res Cardiol (2024) doi: 10.1007/s00395-024-01050-4.
March 2024 Cardioprotection research has left its comfort zone
Please see our editorial in EHJ https://doi.org/10.1093/eurheartj/ehae079 to the manuscript Vilahur et al. https://doi.org/10.1093/eurheartj/ehae107. Pre-clinical studies in clinically relevant animal models will close the translational gap in cardioprotection research.
January 2024 Myocardial ischemia/reperfusion: Translational pathophysiology of ischemic heart disease
Recently published in Med; 5:10-31
A brief summary of the state of the art in myocardial ischemia/reperfusion research with a view on both its coronary vascular and myocardial aspects
January 2024 Differences in vasomotor function of mesenteric arteries between Ossabaw minipigs with predisposition to metabolic syndrome and Göttingen minipigs
Recently published in Am J Physiol Heart Circ Physiol326: H408-H417
Animal models with a predisposition to metabolic syndrome and atherosclerosis are attracting growing interest for translational research, as they may better mimic the variability of patients with cardiovascular disease.
In Ossabaw minipigs, with a polygenic predisposition to metabolic syndrome, but without the diseased phenotype, we characterized that vasoconstriction is more and vasodilation less pronounced in mesenteric arteries than in Göttingen minipigs.
Thus, Ossabaw minipigs may be a more suitable model of human cardiovascular disease.
2023
17.11.2023 Federal Cross of Merit 1st Class: Pathophysiologist Prof. Dr. Dr. hc. Gerd Heusch honored again
16.11.2023
Award of the Doctor Honoris Causa for special services in cardiovascular research at Semmelweis University in Budapest
16.11.2023 Highly cited papers which rank in the top 1 % for field and publication year in the Web of Science
06.10.2023
November 2023 Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection
Reactive oxygen species are signals of cardioprotection and executors of injury
-> this review summarizes the beneficial and detrimental roles of reactive oxygen species in myocardial ischemia/reperfusion injury and cardioprotection.
August 2023 Perspective: mitochondrial STAT3 in cardioprotection
Time-dependent—acute, subacute, chronic—and non-canonical vs. canonical effects of STAT3 activation on myocardial ischemia/reperfusion; created with BioRender.com
ATP adenosine triphosphate, MPTP mitochondrial permeability transition pore, ROS reactive oxygen species, STAT3 signal transducer and activator of transcription 3
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