Cardioprotection works in experimental models - but does it also work in humans? Only through detailed analysis can mechanisms that could in principle also provide cardioprotection in patients be identified and utilized. In a study published in "Circulation Research" (Circ Res; 123: 1152-1163), we demonstrated that the spleen plays a central role as a relay organ in remote cardioprotection. After brief interruptions of the blood flow to the hindleg of a laboratory animal, the spleen is activated via the vagal nervous system and releases cardioprotective substances into the blood stream. This study also demonstrated the close connection between the heart and the immune system in acute myocardial infarction.

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