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PD Dr. rer. nat. Jürgen Thomale

E-Mail
juergen.thomale@uni-uk.de.
Webseite
http://www.uni-due.de/home/fb/ifz/forschung/drl/de_startseite.shtml

Funktionen

  • Privatdozent/in, Institut für Zellbiologie (Tumorforschung)

Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.

    Artikel in Zeitschriften

  • Demuytere, Jesse; Carlier, Charlotte; Van Helden, Tom; Belza, Joke; Vanhaecke, Frank; Xie, Feifan; Vermeulen, An; Weerts, Joseph; Thomale, Jürgen; Denys, Hannelore; Tummers, Philippe; Van Kerschaver, Olivier; Willaert, Wouter; Cosyns, Sarah; Merseburger, Peter; Claeys, Arne; Van Den Eynden, Jimmy; Ceelen, Wim
    Effects of hyperthermia on cisplatin tissue penetration and gene expression in peritoneal metastases : Results from a randomized trial in ovarian cancer
    In: British Journal of Surgery (BJS) Jg. 111 (2024) Nr. 4, znae078
    Online Volltext: dx.doi.org/
  • Klotz, Daniel Martin; Schwarz, Franziska Maria; Dubrovska, Anna; Schuster, Kati; Theis, Mirko; Krüger, Alexander; Kutz, Oliver; Link, Theresa; Wimberger, Pauline; Drukewitz, Stephan; Buchholz, Frank; Thomale, Jürgen; Kuhlmann, Jan Dominik
    Establishment and Molecular Characterization of an In Vitro Model for PARPi-Resistant Ovarian Cancer
    In: Cancers Jg. 15 (2023) Nr. 15, 3774
    Online Volltext: dx.doi.org/ (Open Access)
  • Frank, Daria; Patnana, Pradeep Kumar; Vorwerk, Jan; Mao, Lianghao; Gopal, Lavanya Mokada; Jung, Noelle; Hennig, Thorben; Ruhnke, Leo; Frenz, Joris Maximillian; Kuppusamy, Maithreyan; Autry, Robert; Wei, Lanying; Sun, Kaiyan; Mohammed Ahmed, Helal Mohammed; Künstner, Axel; Busch, Hauke; Müller, Heiko; Hutter, Stephan; Hoermann, Gregor; Liu, Longlong; Xie, Xiaoqing; Al-Matary, Yahya; Nimmagadda, Subbaiah Chary; Cano, Fiorella Charles; Heuser, Michael; Thol, Felicitas; Göhring, Gudrun; Steinemann, Doris; Thomale, Jürgen; Leitner, Theo; Fischer, Anja; Rad, Roland; Röllig, Christoph; Altmann, Heidi; Kunadt, Desiree; Berdel, Wolfgang E.; Hüve, Jana; Neumann, Felix; Klingauf, Jürgen; Calderon, Virginie; Opalka, Bertram; Dührsen, Ulrich; Rosenbauer, Frank; Dugas, Martin; Varghese, Julian; Reinhardt, Hans Christian; von Bubnoff, Nikolas; Möröy, Tarik; Lenz, Georg; Batcha, Aarif M. N.; Giorgi, Marianna; Selvam, Murugan; Wang, Eunice; McWeeney, Shannon K.; Tyner, Jeffrey W.; Stölzel, Friedrich; Mann, Matthias; Jayavelu, Ashok Kumar; Khandanpour, Cyrus; Mokada Gopal, Lavanya; Ahmed, Helal; Charles Cano, Fiorella
    Germ line variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapy
    In: Blood Jg. 142 (2023) Nr. 25, S. 2175 - 2191
    Online Volltext: dx.doi.org/ (Open Access)
  • Hansel, Christine; Hlouschek, Julian; Xiang, Kexu; Melnikova, Margarita; Thomale, Jürgen; Helleday, Thomas; Jendrossek, Verena; Matschke, Johann
    Adaptation to chronic-cycling hypoxia renders cancer cells resistant to mth1-inhibitor treatment which can be counteracted by glutathione depletion
    In: Cells Jg. 10 (2021) Nr. 11, 3040
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Ewers, Katharina M.; Patil, Shilpa; Kopp, Waltraut; Thomale, Jürgen; Quilitz, Tabea; Magerhans, Anna; Wang, Xin; Hessmann, Elisabeth; Dobbelstein, Matthias
    HSP90 Inhibition Synergizes with Cisplatin to Eliminate Basal-like Pancreatic Ductal Adenocarcinoma Cells
    In: Cancers Jg. 13 (2021) Nr. 24, 6163
    Online Volltext: dx.doi.org/ (Open Access)
  • Heinze, Karolin; Hölzer, Martin; Ungelenk, Martin; Gerth, Melanie; Thomale, Jürgen; Heller, Regine; Morden, Claire R.; McManus, Kirk J.; Mosig, Alexander S.; Dürst, Matthias; Runnebaum, Ingo B.; Häfner, Norman
    RUNX3 transcript variants have distinct roles in ovarian carcinoma and differently influence platinum sensitivity and angiogenesis
    In: Cancers Jg. 13 (2021) Nr. 3, S. 476
    Online Volltext: dx.doi.org/ (Open Access)
  • Böckelmann, Lukas; Starzonek, Christin; Niehoff, Ann-Christin; Karst, Uwe; Thomale, Jürgen; Schlüter, Hartmut; Bokemeyer, Carsten; Aigner, Achim; Schumacher, Udo
    Detection of doxorubicin, cisplatin and therapeutic antibodies in formalin-fixed paraffin-embedded human cancer cells
    In: Histochemistry and Cell Biology Jg. 153 (2020) Nr. 5, S. 367 - 377
    Online Volltext: dx.doi.org/ (Open Access)
  • Melnikova, Margarita; Wauer, Ulrike Sophie; Mendus, Diana; Hilger, Ralf Axel; Oliver, Trudy G.; Mercer, Kim; Gohlke, Björn Oliver; Erdmann, Kati; Niederacher, Dieter; Neubauer, Hans; Buderath, Paul; Wimberger, Pauline; Kuhlmann, Jan Dominik; Thomale, Jürgen
    Diphenhydramine increases the therapeutic window for platinum drugs by simultaneously sensitizing tumor cells and protecting normal cells
    In: Molecular Oncology Jg. 14 (2020) Nr. 4, S. 686 - 703
    Online Volltext: dx.doi.org/ (Open Access)
  • Seoane, Marcos; Buhs, Sophia; Iglesias, Pablo; Strauss, Julia; Puller, Ann-Christin; Müller, Jürgen; Gerull, Helwe; Feldhaus, Susanne; Alawi, Malik; Brandner, Johanna M.; Eggert, Dennis; Du, Jinyan; Thomale, Jürgen; Wild, Peter J.; Zimmermann, Martin; Sternsdorf, Thomas; Schumacher, Udo; Nollau, Peter; Fisher, David E.; Horstmann, Martin A.
    Lineage-specific control of TFIIH by MITF determines transcriptional homeostasis and DNA repair
    In: Oncogene Jg. 38 (2019) Nr. 19, S. 3616 - 3635
    Online Volltext: dx.doi.org/ (Open Access)
  • Riaz, Muhammad Assad; Sak, Ali; Erol, Yasin Bahadir; Groneberg, Michael; Thomale, Jürgen; Stuschke, Martin
    Metformin enhances the radiosensitizing effect of cisplatin in non-small cell lung cancer cell lines with different cisplatin sensitivities
    In: Scientific Reports Jg. 9 (2019) S. 1282
    Online Volltext: dx.doi.org/ (Open Access)
  • Riaz, A.; Sak, Ali; Erol, Y. B.; Groneberg, M.; Melnikova, M.; Thomale, Jürgen; Stuschke, Martin
    Combined effects of metformin and cisplatin on radiation sensitivity in non-small cell lung cancer cells
    In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics Jg. 194 (2018) Nr. Suppl.1, S. 100
    Online Volltext: dx.doi.org/ (Open Access)
  • Skowron, Margaretha A.; Melnikova, Margarita; Van Roermund, Joep G. H.; Romano, Andrea; Albers, Peter; Thomale, Jürgen; Schulz, Wolfgang A.; Niegisch, Günter; Hoffmann, Michèle J.
    Multifaceted mechanisms of cisplatin resistance in long-term treated urothelial carcinoma cell lines
    In: International Journal of Molecular Sciences (IJMS) Jg. 19 (2018) Nr. 2, S. 590
    Online Volltext: dx.doi.org/ (Open Access)
  • Leo, Markus; Schmitt, Linda-Isabell; Jastrow, Holger; Thomale, Jürgen; Kleinschnitz, Christoph; Hagenacker, Tim
    Cisplatin alters the function and expression of N-type voltage-gated calcium channels in the absence of morphological damage of sensory neurons.
    In: Molecular Pain Jg. 13 (2017) 1744806917746565
    Online Volltext: dx.doi.org/ (Open Access)
  • Leo, Markus; Schmitt, Linda-Isabell; Erkel, Martin; Melnikova, Margarita; Thomale, Jürgen; Hagenacker, Tim
    Cisplatin-induced neuropathic pain is mediated by upregulation of N-type voltage-gated calcium channels in dorsal root ganglion neurons
    In: Experimental Neurology Jg. 288 (2017) S. 62 - 74
    Online Volltext: dx.doi.org/
  • Ruhe, Lena; Ickert, Stefanie; Hochkirch, Ulrike; Hofmann, Johanna; Beck, Sebastian; Thomale, Jürgen; Linscheid, Michael W.
    Comprehensive Molecular Characterization of a Cisplatin-Specific Monoclonal Antibody
    In: Molecular Pharmaceutics Jg. 14 (2017) Nr. 12, S. 4454 - 4461
    Online Volltext: dx.doi.org/
  • Sánchez-González, Penélope D.; López-Hernández, Francisco J.; Dueñas, Montserrat; Prieto, Marta; Sánchez-López, Elsa; Thomale, Jürgen; Ruiz-Ortega, Marta; López-Novoa, José M.; Morales, Ana I.
    Differential effect of quercetin on cisplatin-induced toxicity in kidney and tumor tissues
    In: Food and Chemical Toxicology Jg. 107 (2017) S. 226 - 236
    Online Volltext: dx.doi.org/
  • Riaz, A. M.; Sak, Ali; Erol, B. Y.; Groneberg, M.; Melnikova, M.; Thomale, Jürgen; Stuschke, Martin
    Metformin potentiates radiosensitizing effect of cisplatin in NSCLC cells
    In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics Jg. 193 (2017) Nr. Suppl.1, S. 27
  • Mary Photini, Stella; Dürst, Matthias; Jansen, Lars; Steinbach, Daniel; Gajda, Mieczyslaw; Sonnemann, Jürgen; Hoffmann, Franziska; Thomale, Jürgen; Runnebaum, Ingo B.; Mosig, Alexander S.; Melnikova, Margarita; Häfner, Norman; Peters, Sven; Kritsch, Daniel
    Tribbles 2 mediates cisplatin sensitivity and DNA damage response in epithelial ovarian cancer
    In: International Journal of Cancer Jg. 141 (2017) Nr. 8, S. 1600 - 1614
    Online Volltext: dx.doi.org/
  • Hampp, Stephanie; Kiessling, Tina; Buechle, Kerstin; Mansilla, Sabrina F; Thomale, Jürgen; Rall, Melanie; Ahn, Jinwoo; Pospiech, Helmut; Gottifredi, Vanesa; Wiesmüller, Lisa
    DNA damage tolerance pathway involving DNA polymerase ? and the tumor suppressor p53 regulates DNA replication fork progression
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Jg. 113 (2016) Nr. 30, S. E4311 - 9
    Online Volltext: dx.doi.org/ (Open Access)
  • Jokić, Mladen; Vlašić, Ignacija; Rinneburger, Miriam; Klümper, Niklas; Spiro, Judith; Vogel, Wenzel; Offermann, Anne; Kümpers, Christiane; Fritz, Christian; Schmitt, Anna; Riabinska, Arina; Wittersheim, Maike; Michels, Sebastian; Ozretić, Luka; Florin, Alexandra; Welcker, Daniela; Akyuz, Mehmet Deniz; Nowak, Michael; Erkel, Martin; Wolf, Jürgen; Büttner, Reinhard; Schumacher, Björn; Thomale, Jürgen; Persigehl, Thorsten; Maintz, David; Perner, Sven; Reinhardt, Hans Christian
    Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner
    In: Molecular Cancer Research Jg. 14 (2016) Nr. 11, S. 1110 - 1123
    Online Volltext: dx.doi.org/
  • Krüger, Katharina; Ziegler, Verena; Hartmann, Christina; Henninger, Christian; Thomale, Jürgen; Schupp, Nicole; Fritz, Gerhard
    Lovastatin prevents cisplatin-induced activation of pro-apoptotic DNA damage response (DDR) of renal tubular epithelial cells
    In: Toxicology and Applied Pharmacology Jg. 292 (2016) S. 103 - 114
    Online Volltext: dx.doi.org/
  • Bretz, Anne Catherine; Gittler, Miriam P; Charles, Joël P; Gremke, Niklas; Eckhardt, Ines; Mernberger, Marco; Mandic, Robert; Thomale, Jürgen; Nist, Andrea; Wanzel, Michael; Stiewe, Thorsten
    ΔNp63 activates the Fanconi anemia DNA repair pathway and limits the efficacy of cisplatin treatment in squamous cell carcinoma
    In: Nucleic Acids Research Jg. 44 (2016) Nr. 7, S. 3204 - 3218
    Online Volltext: dx.doi.org/ (Open Access)
  • Paul-Konietzko, Katja; Thomale, Jürgen; Arakawa, Hiroshi; Iliakis, George
    DNA Ligases I and III Support Nucleotide Excision Repair in DT40 Cells with Similar Efficiency
    In: Photochemistry and Photobiology Jg. 91 (2015) Nr. 5, S. 1173 - 1180
    Online Volltext: dx.doi.org/
  • Zivanovic, Oliver; Abramian, Alina; Kullmann, Maximilian; Fuhrmann, Christine; Coch, Christoph; Hoeller, Tobias; Ruehs, Hauke; Keyver-Paik, Mignon Denise; Rudlowski, Christian; Weber, Stefan; Kiefer, Nicholas; Poelcher, Martin L.; Thiesler, Thore; Rostamzadeh, Babak; Mallmann, Michael; Schaefer, Nico; Permantier, Maryse; Latten, Sandra; Kalff, Joerg; Thomale, Jürgen; Jaehde, Ulrich; Kuhn, Walter C.
    HIPEC ROC I : A phase i study of cisplatin administered as hyperthermic intraoperative intraperitoneal chemoperfusion followed by postoperative intravenous platinum-based chemotherapy in patients with platinum-sensitive recurrent epithelial ovarian cancer
    In: International Journal of Cancer Jg. 136 (2015) Nr. 3, S. 699 - 708
    Online Volltext: dx.doi.org/ (Open Access)
  • Krüger, Katharina; Thomale, Jürgen; Stojanović, Nikolina; Osmak, Maja; Henninger, Christian; Bormann, Stefanie; Fritz, Gerhard
    Platinum-induced kidney damage : Unraveling the DNA damage response (DDR) of renal tubular epithelial and glomerular endothelial cells following platinum injury
    In: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Jg. 1853 (2015) Nr. 3, S. 685 - 698
    Online Volltext: dx.doi.org/ (Open Access)
  • Keitel, Ulrike; Scheel, Andreas; Thomale, Jürgen; Halpape, Rovena; Kaulfuß, Silke; Scheel, Christina; Dobbelstein, Matthias
    Bcl-xL mediates therapeutic resistance of a mesenchymal breast cancer cell subpopulation
    In: OncoTarget Jg. 5 (2014) Nr. 23, S. 11778 - 11791
    Online Volltext: dx.doi.org/ (Open Access)
  • Barr, M. P.; Rausch, R.; Thomale, Jürgen; Richard, D.; Cuffe, S.; Finn, S.; O'Byrne, K. J.
    Inhibition of PARP activity by PJ34 sensitises NSCLC cells to cisplatin
    In: Lung Cancer Jg. 83 (2014) Nr. Suppl. 1, S. 2
    Online Volltext: dx.doi.org/
  • Raluy, Laia Pagerols; Nollau, Peter; Brandner, Johanna M.; Wild, Peter J.; Zimmermann, Martin; Schumacher, Udo; Kaufmann, Karoline; Horstmann, Martin A.; Strauss, Julia; Thomale, Jürgen; Dierck, Kevin; Fisher, David E.; Seoane, Marcos; Du, Jinyan
    Regulation of the functional interface between nucleotide excision repair and transcription by MITF modulates melanoma growth
    In: Cancer Research Jg. 74 (2014) Nr. 19 Suppl., S. 2950
    Online Volltext: dx.doi.org/
  • Houthuijzen, JuliaM; Daenen, LauraGM; Roodhart, JeanineML; Govaert, KlaasM; Smith, MichelleE; Thomale, Jürgen; Sadatmand, SaharJ; Rosing, Hilde; Kruse, Fabian; van Rooijen, Nico; Beijnen, JosH; Borst, Piet; Rottenberg, Sven; Haribabu, Bodduluri; Voest, EmileE
    Splenic macrophages induce chemotherapy resistance via DNA damage repair
    In: Cancer Research Jg. 74 (2014) Nr. Suppl. 19, S. 3771
    Online Volltext: dx.doi.org/
  • Funk, Florian; Krüger, Katharina; Henninger, Christian; Wätjen, Wim; Proksch, Peter; Thomale, Jürgen; Fritz, Gerhard
    Spongean alkaloids protect rat kidney cells against cisplatin-induced cytotoxicity
    In: Anti-Cancer Drugs Jg. 25 (2014) Nr. 8, S. 917 - 929
    Online Volltext: dx.doi.org/
  • Krueger, K.; Fritz, G.; Thomale, Jürgen
    Comparative analysis of the sensitivity of normal rat kidney cells towards different types of platinum compounds
    In: Naunyn-Schmiedeberg's Archives of Pharmacology Jg. 386 (2013) Nr. Suppl. 1, S. 45
  • Friboulet, Luc; Olaussen, Ken André; Pignon, Jean-Pierre; Shepherd, Frances A.; Tsao, Ming-Sound; Graziano, Stephen; Kratzke, Robert; Douillard, Jean-Yves; Seymour, Lesley; Pirker, Robert; Filipits, Martin; André, Fabrice; Solary, Eric; Ponsonnailles, Florence; Robin, Angélique; Stoclin, Annabelle; Dorvault, Nicolas; Commo, Frédéric; Adam, Julien; Vanhecke, Elsa; Saulnier, Patrick; Thomale, Jürgen; Le Chevalier, Thierry; Dunant, Ariane; Rousseau, Vanessa; Le Teuff, Gwénaël; Brambilla, Elisabeth; Soria, Jean-Charles
    ERCC1 isoform expression and DNA repair in non-small-cell lung cancer
    In: The New England Journal of Medicine Jg. 368 (2013) Nr. 12, S. 1101 - 1110
    Online Volltext: dx.doi.org/
  • Eicher, Carmen; Dewerth, Alexander; Thomale, Jürgen; Ellerkamp, Verena; Hildenbrand, Sibylle L.; Warmann, Steven W.; Fuchs, Jörg; Armeanu-Ebinger, Sorin
    Effect of sorafenib combined with cytostatic agents on hepatoblastoma cell lines and xenografts
    In: British Journal of Cancer (BJC) Jg. 108 (2013) Nr. 2, S. 334 - 341
    Online Volltext: dx.doi.org/ (Open Access)
  • Berulava, Tea; Ziehe, Matthias; Klein-Hitpaß, Ludger; Mladenov, Emil; Thomale, Jürgen; Rüther, Ulrich; Horsthemke, Bernhard
    FTO levels affect RNA modification and the transcriptome
    In: European Journal of Human Genetics Jg. 21 (2013) Nr. 3, S. 317 - 323
    Online Volltext: dx.doi.org/
  • Nel, I.; Gauler, Thomas; Eberhardt, Wilfried; Nickel, A. C.; Schuler, Martin; Thomale, Jürgen; Hoffmann, Andreas-Claudius
    Formation and repair kinetics of Pt-(GpG) DNA adducts in extracted circulating tumour cells and response to platinum treatment
    In: British Journal of Cancer (BJC) Jg. 109 (2013) Nr. 5, S. 1223 - 1229
    Online Volltext: dx.doi.org/ (Open Access)
  • Barr, Martin P.; Gray, Steven G.; Hoffmann, Andreas-Claudius; Hilger, Ralf A.; Thomale, Jürgen; O'Flaherty, John D.; Fennell, Dean A.; Richard, Derek; O'Leary, John J.; O'Byrne, Kenneth J.
    Generation and characterisation of cisplatin-resistant non-small cell lung cancer cell lines displaying a stem-like signature
    In: PLoS ONE Jg. 8 (2013) Nr. 1, e54193
    Online Volltext: dx.doi.org/ (Open Access)
  • Olaussen, Ken A.; Adam, Julien; Vanhecke, Elsa; Vielh, Philippe; Pirker, Robert; Friboulet, Luc; Popper, Helmut; Robin, Angélique; Commo, Fréderic; Thomale, Jürgen; Kayitalire, Louis; Filipits, Martin; Le Chevalier, Thierry; André, Fabrice; Brambilla, Elisabeth; Soria, Jean-Charles
    PARP1 impact on DNA repair of platinum adducts: Preclinical and clinical read-outs
    In: Lung Cancer Jg. 80 (2013) Nr. 2, S. 216 - 222
    Online Volltext: dx.doi.org/
  • Rausch, Raya; Barr, MartinP; Thomale, Jürgen; Richard, Derek; OByrne, Kenneth
    Parb inhibition increases sensitivity of NSCLC cells to cisplatin
    In: Journal of Thoracic Oncology Jg. 8 (2013) Nr. Suppl. 2, S. 470
  • Fenske, Annabelle E.; Glaesener, Stephanie; Bokemeyer, Carsten; Thomale, Jürgen; Dahm-Daphi, Jochen; Honecker, Friedemann; Dartsch, Dorothee C.
    Cisplatin resistance induced in germ cell tumour cells is due to reduced susceptibility towards cell death but not to altered DNA damage induction or repair
    In: Cancer Letters Jg. 324 (2012) Nr. 2, S. 171 - 178
    Online Volltext: dx.doi.org/
  • Thomale, Jürgen
    Efficient pharmacological prevention of the major side effects of cisplatin without affecting the antineoplastic effiacy in vivo
    In: Annals of Oncology Jg. 23 (2012) Nr. Suppl. 1, S. 25
  • Ziehe, Matthias; Esteban-Fernández, Diego; Hochkirch, Ulrike; Thomale, Jürgen; Linscheid, Michael W.
    On the complexity and dynamics of in vivo Cisplatin-DNA adduct formation using HPLC/ICP-MS
    In: Metallomics Jg. 4 (2012) Nr. 10, S. 1098 - 1104
    Online Volltext: dx.doi.org/
  • Galluzzi, Lorenzo; Vitale, Ilio; Senovilla, Laura; Olaussen, Ken André; Pinna, Guillaume; Eisenberg, Tobias; Goubar, Aïcha; Martins, Isabelle; Michels, Judith; Kratassiouk, Gueorgui; Carmona-Gutierrez, Didac; Scoazec, Marie; Vacchelli, Erika; Schlemmer, Frederic; Kepp, Oliver; Shen, Shensi; Tailler, Maximilien; Niso-Santano, Mireia; Morselli, Eugenia; Criollo, Alfredo; Adjemian, Sandy; Jemaà, Mohamed; Chaba, Kariman; Pailleret, Claire; Michaud, Mickaël; Pietrocola, Federico; Tajeddine, Nicolas; de La Motte Rouge, Thibault; Araujo, Natalia; Morozova, Nadya; Robert, Thomas; Ripoche, Hugues; Commo, Frederic; Besse, Benjamin; Validire, Pierre; Fouret, Pierre; Robin, Angélique; Dorvault, Nicolas; Girard, Philippe; Gouy, Sébastien; Pautier, Patricia; Jägemann, Nora; Nickel, Ann-Christin; Marsili, Sabrina; Paccard, Caroline; Servant, Nicolas; Hupé, Philippe; Behrens, Carmen; Behnam-Motlagh, Parviz; Kohno, Kimitoshi; Cremer, Isabelle; Damotte, Diane; Alifano, Marco; Midttun, Øivind; Ueland, Per Magne; Lazar, Vladimir; Dessen, Philippe; Zischka, Hans; Chatelut, Etienne; Castedo, Maria; Madeo, Frank; Barillot, Emmanuel; Thomale, Jürgen; Wistuba, Ignacio Ivan; Sautès-Fridman, Catherine; Zitvogel, Laurence; Soria, Jean-Charles; Harel-Bellan, Annick; Kroemer, Guido; Olaussen, Ken André; de La Motte Rouge, Thibault; Ueland, Per Magne; Wistuba, Ignacio Ivan
    Prognostic Impact of Vitamin B6 Metabolism in Lung Cancer
    In: Cell Reports Jg. 2 (2012) Nr. 2, S. 257 - 269
    Online Volltext: dx.doi.org/ (Open Access)
  • Mowaka, Shereen; Ziehe, Matthias; Mohamed, Dalia; Hochkirch, Ulrike; Thomale, Jürgen; Linscheid, Michael W.
    Structures of oxaliplatin-oligonucleotide adducts from DNA
    In: Journal of Mass Spectrometry Jg. 47 (2012) Nr. 10, S. 1282 - 1293
    Online Volltext: dx.doi.org/
  • Boeckmann, L.; Nickel, A-C; Kuschal, C.; Schaefer, A.; Thoms, K-M; Schoen, M. P.; Thomale, Jürgen; Emmert, S.
    Differential Melanoma-Chemoresistence to Temozolomide within varying Treatment Schemes : DNA-Damage-Accumulation as Determinants
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) Jg. 9 (2011) Nr. 9, S. 791 - 791
  • Wang, Qi-En; Milum, Keisha; Han, Chunhua; Huang, Yi-Wen; Wani, Gulzar; Thomale, Jürgen; Wani, Altaf A.
    Differential contributory roles of nucleotide excision and homologous recombination repair for enhancing cisplatin sensitivity in human ovarian cancer cells
    In: Molecular Cancer (2011) 24
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Boeckmann, Lars; Nickel, Ann-Christin; Kuschal, Christiane; Schaefer, Annika; Thoms, Kai-Martin; Schön, Michael P; Thomale, Jürgen; Emmert, Steffen
    Temozolomide chemoresistance heterogeneity in melanoma with different treatment regimens : DNA damage accumulation contribution
    In: Melanoma Research Jg. 21 (2011) Nr. 3, S. 206 - 216
    Online Volltext: dx.doi.org/
  • Gutekunst, Matthias; Oren, Moshe; Weilbacher, Andrea; Dengler, Michael A.; Markwardt, Christiane; Thomale, Jürgen; Aulitzky, Walter E.; van der Kuip, Heiko
    p53 Hypersensitivity Is the Predominant Mechanism of the Unique Responsiveness of Testicular Germ Cell Tumor (TGCT) Cells to Cisplatin
    In: PLoS ONE Jg. 6 (2011) Nr. 4,
    Online Volltext: dx.doi.org/ (Open Access)
  • Oliver, Trudy G.; Mercer, Kim L.; Sayles, Leanne C.; Burke, James R.; Mendus, Diana; Lovejoy, Katherine S.; Cheng, Mei-Hsin; Subramanian, Aravind; Mu, David; Powers, Scott; Crowley, Denise; Bronson, Roderick T.; Whittaker, Charles A.; Bhutkar, Arjun; Lippard, Stephen J.; Golub, Todd; Thomale, Jürgen; Jacks, Tyler; Sweet-Cordero, E. Alejandro
    Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer
    In: Genes and Development Jg. 24 (2010) Nr. 8, S. 837 - 852
    Online Volltext: dx.doi.org/
  • Usanova, Svetlana; Piée-Staffa, Andrea; Sied, Ulrike; Thomale, Jürgen; Schneider, Astrid; Kaina, Bernd; Köberle, Beate
    Cisplatin sensitivity of testis tumour cells is due to deficiency in interstrand-crosslink repair and low ERCC1-XPF expression
    In: Molecular Cancer Jg. 9 (2010) 248
    Online Volltext: dx.doi.org/ (Open Access)
  • Geis, Christian; Graulich, M.; Wissmann, Andreas; Hagenacker, Tim; Thomale, Jürgen; Sommer, Claudia L.; Schäfers, Maria
    Evoked pain behavior and spinal glia activation is dependent on tumor necrosis factor receptor 1 and 2 in a mouse model of bone cancer pain
    In: Neuroscience Jg. 169 (2010) Nr. 1, S. 463 - 474
    Online Volltext: dx.doi.org/
  • Yoon, Min-Suk; Bechmann, Lars Peter; Obermann, Mark; Yepnjouo, Olivia; Egensperger, Rupert; Gerken, Guido; Katsarava, Zaza; Thomale, Jürgen; Holtmann, Gerald
    Recombinant human erythropoietin counteracts cisplatin-induced visceral hyperalgesia
    In: Neuroscience Bulletin Jg. 26 (2010) Nr. 4, S. 282 - 288
    Online Volltext: dx.doi.org/
  • Aleksunes, Lauren M.; Goedken, Michael J.; Rockwell, Cheryl E.; Thomale, Jürgen; Manautou, Jose E.; Klaassen, Curtis D.
    Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity
    In: The Journal of Pharmacology and Experimental Therapeutics Jg. 335 (2010) Nr. 1, S. 2 - 12
    Online Volltext: dx.doi.org/ (Open Access)
  • Eisele, Lewin; Prinz, Robert; Klein-Hitpaß, Ludger; Nückel, Holger; Lowinksi, Kerstin; Thomale, Jürgen; Möller, Lars; Dührsen, Ulrich; Dürig, Jan
    Combined PER2 and CRY1 expression predicts outcome in chronic lymphocytic leukemia
    In: European Journal of Haematology Jg. 83 (2009) Nr. 4, S. 320 - 327
    Online Volltext: dx.doi.org/
  • Yoon, Min-Suk; Katsarava, Zaza; Obermann, Mark; Schäfers, Maria; Liedert, Bernd; Dzagnidze, Anna; Kribben, Andreas; Egensperger, Rupert; Limmroth, Volker; Diener, Hans Christoph; Thomale, Jürgen
    Erythropoietin overrides the triggering effect of DNA platination products in a mouse model of Cisplatin-induced neuropathy
    In: BMC Neuroscience Jg. 10 (2009) 77
    Online Volltext: dx.doi.org/ (Open Access)
  • Hüttmann, Andreas; Klein-Hitpaß, Ludger; Thomale, Jürgen; Deenen, R.; Nückel, Holger; Ebeling, Peter; Führer, A.; Edelmann, J.; Sellmann, Ludger; Dührsen, Ulrich; Dürig, Jan
    Gene expression signatures separate B-cell chronic lymphocytic leukaemia prognostic subgroups defined by ZAP-70 and CD38 expression status
    In: Leukemia Jg. 20 (2006) Nr. 10, S. 1774 - 1782
    Online Volltext: dx.doi.org/

    • Abstracts

  • Qiu, Ye; Mladenov, Emil; Thomale, Jürgen; Sak, Ali; Stuschke, Martin; Iliakis, George
    Cell cycle specific analysis of cisplatin-radiation interactions : Focus on DNA double strand break induction and processing
    In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics Jg. 199 (2023)
    Online Volltext: dx.doi.org/ (Open Access)
  • Yasin Bahadir, Erol; Sak, Ali; Groneberg, Michael; Thomale, Jürgen; Iliakis, George; Stuschke, Martin
    Effect of combined Cisplatin treatment and Mre11 inhibition on radiation induced DSB Repair in NSCLC cell lines and human fibroblast cells
    In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics Jg. 199 (2023) Nr. Suppl. 1, S. S138
    Online Volltext: dx.doi.org/ (Open Access)
  • Benduhn, US; Melnikova, Mariya; Gohlke, BO; Thomale, Jürgen; Wimberger, Pauline; Kuhlmann, Jan Dominik;
    Diphenhydramin als potentieller Platinsensitizer für das Ovarialkarzinom
    XXIX. Wissenschaftliche Tagung der Arbeitsgemeinschaft für gynäkologische Onkologie (AGO) der Österreichischen Gesellschaft für Gynäkologie und Geburtshilfe (OEGGG) und 18. Österreichischer Kongress „Krebs bei der Frau“, 15.-17.04.2021, Virtuell,
    In: Geburtshilfe und Frauenheilkunde Jg. 81 (2021) Nr. 6, S. E38 - E39
    Online Volltext: dx.doi.org/
  • Frank, D.; Jayavelu, A. K.; Wei, L.; Al-Matary, Yahya; Patnana, P. K.; Nimmagadda, S. C.; Heuser, M.; Thol, F.; Göhring, G.; Thomale, Jürgen; Pfaus, A.; Rad, R.;
    A single nucleotide polymorphism of the transcription factor Growth Factor Independence 1 (GFI1) accelerates AML evolution and sensitizes AML cells to treatment with DNA repair inhibitors
    Virtuelle Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie, 09.–11. Oktober 2020,
    In: Oncology Research and Treatment Jg. 43 (2020) Nr. Suppl. 4, S. 36 - 37
    Online Volltext: dx.doi.org/ (Open Access)
  • Leo, M.; Schmitt, L. I.; Erkel, M.; Melnikova, M.; Thomale, Jürgen; Hagenacker, Tim
    Cisplatin-induced neuropathic pain is mediated by N-type voltage-gated calcium channels
    In: Acta Physiologica Jg. 216 (2016) Nr. Suppl. 707, Special Issue: Abstracts of the 95th Annual Meeting of the German Physiological Society, 3–5 March 2016, S. 87
    Online Volltext: dx.doi.org/
  • Krueger, K.; Thomale, Jürgen; Fritz, G.;
    Characterization of the stress response of normal rat kidney cells to platinating anticancer drugs and modulation by lipid lowering drugs
    Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie e.V., 81th Annual Meeting, March 10 - 12, 2015, Kiel, Germany,
    In: Naunyn-Schmiedeberg's Archives of Pharmacology Jg. 388 (2015) Nr. Suppl.1, S. 66
    Online Volltext: dx.doi.org/
  • Schmitt, L. I.; Leo, M.; Thomale, Jürgen; Hagenacker, Tim;
    Oxaliplatin modulates voltage-gated calcium channel currents in small DRG neurons
    94th Annual Meeting of the German Physiological Society, 5‐7 March 2015, Magdeburg, Germany,
    In: Acta Physiologica Jg. 213 (2015) Nr. Suppl. 699, S. 68
    Online Volltext: dx.doi.org/
  • Leo, M.; Schmitt, L. I.; Thomale, Jürgen; Hagenacker, Tim;
    Subtype-dependent modulation of voltage-gated calcium channels in small dorsal root ganglion neurons by cisplatin
    94th Annual Meeting of the German Physiological Society, 5‐7 March 2015, Magdeburg, Germany,
    In: Acta Physiologica Jg. 213 (2015) Nr. Suppl. 699, S. 69
  • Nel, I.; Gauler, Thomas; Nickel, A.; Eberhardt, Wilfried; Thomale, Jürgen; Schuler, Martin; Hoffmann, A.;
    Prä-therapeutische ex-vivo Reparatur Kinetiken von Cisplatin-DNA-Addukten in Zirkulierenden Tumorzellen als Platin-Resistenz Test
    119. Kongress der Deutschen Gesellschaft für Innere Medizin e.V., 06. - 09. April 2013, Wiesbaden,
    In: Der Internist Jg. 54 (2013) Nr. Suppl. 1, S. 95 - 96
    Online Volltext: dx.doi.org/
  • Friboulet, Luc; Thomale, Jürgen; Commo, Frederic; Saulnier, Patrick; Dorvault, Nicolas; Olaussen, Ken; Soria, Jean-Charles
    Functional characterization of ERCC1 isoforms in NSCLC
    In: Cancer Research Jg. 71 (2011) Nr. 8, Suppl., S. 3895
    Online Volltext: dx.doi.org/

    • Beiträge in Sammelwerken und Tagungsbänden

  • Melnikova, Margarita; Thomale, Jürgen
    Visualization and Quantitative Measurement of Drug-Induced Platinum Adducts in the Nuclear DNA of Individual Cells by an Immuno-Cytological Assay
    In: Urothelial Carcinoma: Methods and Protocols / Schulz, Wolfgang A.; Hoffmann, Michèle J.; Niegisch, Günter (Hrsg.) 2018, S. 351 - 358
    Online Volltext: dx.doi.org/

    • Poster / Posterbeiträge

  • Barr, M. P.; Gray, S. G.; Fennell, D. A.; O'Leary, J. J.; Richard, D.; Thomale, Jürgen; Hoffmann, Andreas-Claudius; O'Byrne, K. J.;
    MicroRNA profiling and cisplatin–DNA interactions in an isogenic model of cisplatin resistant NSCLC cell lines
    11th Annual British Thoracic Oncology Group Conference, 23-25 January 2013, Dublin, Ireland,
    In: Lung Cancer Jg. 79 (2013) Nr. Suppl. 1, S. S1
    Online Volltext: dx.doi.org/
  • Nell, I.; Gauler, Thomas; Nickel, A. C.; Alotaibi, S.; Thomale, Jürgen; Schuler, Martin; Hoffmann, Andreas-Claudius;
    Pre-therapeutic ex-vivo repair kinetics of cisplatin-DNA-adducts in circulating tumor cells (CTC) as platinum resistance test
    11th Annual British Thoracic Oncology Group Conference, 23-25 January 2013, Dublin, Ireland,
    In: Lung Cancer Jg. 79 (2013) Nr. Suppl. 1, S. S2
    Online Volltext: dx.doi.org/
  • Barr, M.; Gray, S. G.; Fennell, D. A.; O'Leary, J. J.; Richard, D.; Thomale, Jürgen; Hoffmann, Andreas-Claudius; O'Byrne, K. J.;
    Microrna profiling and CDDP-GPG dna adduct formation analysis in a panel of cisplatin resistant non-small cell lung cancer cell lines
    37th ESMO Congress, 28 September - 2 October 2012, Vienna, Austria,
    In: Annals of Oncology Jg. 23 (2012) Nr. Suppl. 9, S. ix68
    Online Volltext: dx.doi.org/