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Prof. Dr. med. Winfried Siffert

Telefon
+49 201 723 3470
E-Mail
winfried.siffert@uk-essen.de
Webseite
http://www.uni-due.de/pharmakogenetik/index.php

Funktionen

  • Geschäftsführende/r Direktor/in, Institut für Pharmakogenetik

Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.

    Artikel in Zeitschriften

  • Schönfelder, Kristina; Möhlendick, Birte; Eisenberger, Ute; Kribben, Andreas; Siffert, Winfried; Heinemann, Falko M.; Gäckler, Anja; Wilde, Benjamin; Friebus-Kardash, Justa
    Early CYP3A5 Genotype-Based Adjustment of Tacrolimus Dosage Reduces Risk of De Novo Donor-Specific HLA Antibodies and Rejection among CYP3A5-Expressing Renal Transplant Patients
    In: Diagnostics Jg. 14 (2024) Nr. 19, 2202
    Online Volltext: dx.doi.org/ (Open Access)
  • Zacher, Christoph; Schönfelder, Kristina; Rohn, Hana; Siffert, Winfried; Möhlendick, Birte
    The single nucleotide polymorphism rs4986790 (c.896A>G) in the gene TLR4 as a protective factor in corona virus disease 2019 (COVID-19)
    In: Frontiers in Immunology Jg. 15 (2024) 1355193
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Büchter, Matthias; Dorn, Dominik; Möhlendick, Birte; Siffert, Winfried; Baba, Hideo Andreas; Gerken, Guido; Kahraman, Alisan
    Characteristics and Long-Term Outcome of 535 Patients with Autoimmune Hepatitis : The 20-Year Experience of a High-Volume Tertiary Center
    In: Journal of Clinical Medicine (JCM) Jg. 12 (2023) Nr. 13, 4192
    Online Volltext: dx.doi.org/ (Open Access)
  • Čiučiulkaitė, Ieva; Siffert, Winfried; Elsner, Carina; Dittmer, Ulf; Wichert, Marc; Wagner, Bernd; Volbracht, Lothar; Mosel, Frank; Möhlendick, Birte
    Influence of the Single Nucleotide Polymorphisms rs12252 and rs34481144 in IFITM3 on the Antibody Response after Vaccination against COVID-19
    In: Vaccines Jg. 11 (2023) Nr. 7, 1257
    Online Volltext: dx.doi.org/ (Open Access)
  • Birkner, Simon; Möhlendick, Birte; Wilde, Benjamin; Schoenfelder, Kristina; Boss, Kristina; Siffert, Winfried; Kribben, Andreas; Friebus-Kardash, Justa
    Single-Nucleotide Polymorphism in Genes Encoding G Protein Subunits GNB3 and GNAQ Increase the Risk of Cardiovascular Morbidity among Patients Undergoing Renal Replacement Therapy
    In: International Journal of Molecular Sciences (IJMS) Jg. 24 (2023) Nr. 20, 15260
    Online Volltext: dx.doi.org/ (Open Access)
  • Peitz, Tobias; Möhlendick, Birte; Eisenberger, Ute; Siffert, Winfried; Heinemann, Falko M.; Kribben, Andreas; Friebus-Kardash, Justa
    CC Genotype of GNAS c.393C>T (rs7121) Polymorphism Has a Protective Effect against Development of BK Viremia and BKV-Associated Nephropathy after Renal Transplant
    In: Pathogens Jg. 11 (2022) Nr. 10, 1138
    Online Volltext: dx.doi.org/ (Open Access)
  • Friebus-Kardash, Justa; Nela, Ejona; Möhlendick, Birte; Kribben, Andreas; Siffert, Winfried; Heinemann, Falko M.; Eisenberger, Ute
    Development Of De Novo Donor-Specific HLA Antibodies and ABMR in Renal Transplant Patients Depends on CYP3A5 Genotype
    In: Transplantation Jg. 106 (2022) Nr. 5, S. 1031 - 1042
    Online Volltext: dx.doi.org/ (Open Access)
  • Peitz, Tobias; Möhlendick, Birte; Siffert, Winfried; Heinemann, Falko M.; Kribben, Andreas; Eisenberger, Ute; Friebus-Kardash, Justa
    GNB3 c.825C>T (rs5443) Polymorphism and Risk of Acute Cardiovascular Events after Renal Allograft Transplant
    In: International Journal of Molecular Sciences (IJMS) Jg. 23 (2022) Nr. 17, 9783
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Čiučiulkaitė, Ieva; Möhlendick, Birte; Thümmler, Laura; Fisenkci, Neslinur; Elsner, Carina; Dittmer, Ulf; Siffert, Winfried; Lindemann, Monika
    GNB3 c.825c>T polymorphism influences T-cell but not antibody response following vaccination with the mRNA-1273 vaccine
    In: Frontiers in Genetics Jg. 13 (2022) 932043
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Möhlendick, Birte; Čiučiulkaitė, Ieva; Elsner, Carina; Anastasiou, Olympia E.; Trilling, Mirko; Wagner, Bernd; Zwanziger, Denise; Jöckel, Karl-Heinz; Dittmer, Ulf; Siffert, Winfried
    Individuals With Weaker Antibody Responses After Booster Immunization Are Prone to Omicron Breakthrough Infections
    In: Frontiers in Immunology Jg. 13 (2022) 907343
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Möhlendick, Birte; Schönfelder, Kristina; Zacher, Christoph; Elsner, Carina; Rohn, Hana; Konik, Margarethe; Thümmler, Laura; Rebmann, Vera; Lindemann, Monika; Jöckel, Karl-Heinz; Siffert, Winfried
    The GNB3 c.825C > T (rs5443) polymorphism and protection against fatal outcome of corona virus disease 2019 (COVID-19)
    In: Frontiers in Genetics Jg. 13 (2022) 960731
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Möhlendick, Birte; Schönfelder, Kristina; Breuckmann, Katharina; Elsner, Carina; Babel, Nina; Balfanz, Paul; Dahl, Edgar; Dreher, Michael; Fistera, David; Herbstreit, Frank; Hölzer, Bodo; Koch, Michael; Kohnle, Matthias; Marx, Nikolaus; Risse, Joachim; Schmidt, Karsten; Skrzypczyk, Sarah; Sutharsan, Sivagurunathan; Taube, Christian; Westhoff, Timm H.; Jöckel, Karl-Heinz; Dittmer, Ulf; Siffert, Winfried; Kribben, Andreas
    ACE2 polymorphism and susceptibility for SARS-CoV-2 infection and severity of COVID-19
    In: Pharmacogenetics and Genomics Jg. 31 (2021) Nr. 8, S. 165 - 171
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Stegen, Maike; Engler, Andrea; Ochsenfarth, Crista; Manthey, Iris; Peters, Jürgen; Siffert, Winfried; Frey, Ulrich
    Characterization of the G protein-coupled receptor kinase 6 promoter reveals a functional CREB binding site
    In: PLoS ONE Jg. 16 (2021) Nr. 2, S. e0247087
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Radulovic, Ivana; Dogan, Burcin; Dohna-Schwake, Christian; Schündeln, Michael; Siffert, Winfried; Möhlendick, Birte
    NAT2 polymorphisms as a cause of metamizole-induced agranulocytosis
    In: Pharmacogenetics and Genomics Jg. 31 (2021) Nr. 6, S. 140 - 143
    Online Volltext: dx.doi.org/
  • Schönfelder, Kristina; Breuckmann, Katharina; Elsner, Carina; Dittmer, Ulf; Fistera, David; Herbstreit, Frank; Risse, Joachim; Schmidt, Karsten-Daniel; Sutharsan, Sivagurunathan; Taube, Christian; Jöckel, Karl-Heinz; Siffert, Winfried; Kribben, Andreas; Möhlendick, Birte
    The influence of IFITM3 polymorphisms on susceptibility to SARS-CoV-2 infection and severity of COVID-19
    In: Cytokine Jg. 142 (2021) S. 155492
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Schönfelder, Kristina; Breuckmann, Katharina; Elsner, Carina; Dittmer, Ulf; Fistera, David; Herbstreit, Frank; Risse, Joachim; Schmidt, Karsten-Daniel; Sutharsan, Sivagurunathan; Taube, Christian; Jöckel, Karl-Heinz; Siffert, Winfried; Kribben, Andreas; Möhlendick, Birte
    Transmembrane serine protease 2 Polymorphisms and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection : A German Case-Control Study
    In: Frontiers in Genetics Jg. 12 (2021) 667231
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Klenke, Stefanie; Lehmann, Nils; Erbel, Raimund; Jöckel, Karl-Heinz; Siffert, Winfried; Frey, Ulrich; Peters, Jürgen
    Genetic variations in G-protein signal pathways influence progression of coronary artery calcification : Results from the Heinz Nixdorf Recall study
    In: Atherosclerosis Jg. 310 (2020) S. 102 - 108
    Online Volltext: dx.doi.org/
  • Huetter, Franz Korbinian; Moehlendick, Birte; Knop, Dietmar; Siffert, Winfried
    Lack of association of common polymorphisms linked to empathic behavior with self-reported trait empathy in healthy volunteers
    In: Hormones and Behavior Jg. 126 (2020) S. 104841
    Online Volltext: dx.doi.org/
  • Bergmann, Lars; Nowak, Hartmuth; Siffert, Winfried; Peters, Jürgen; Adamzik, Michael; Koos, Björn; Rahmel, Tim
    Major Adverse Kidney Events Are Associated with the Aquaporin 5 -1364A/C Promoter Polymorphism in Sepsis : A Prospective Validation Study
    In: Cells Jg. 9 (2020) Nr. 4, 904
    Online Volltext: dx.doi.org/ (Open Access)
  • Rump, Katharina; Unterberg, Matthias; Dahlke, Agnes; Nowak, Hartmuth; Koos, Björn; Bergmann, Lars; Siffert, Winfried; Schäfer, Simon; Peters, Jürgen; Adamzik, Michael; Rahmel, Tim
    DNA methylation of a NF-κB binding site in the aquaporin 5 promoter impacts on mortality in sepsis
    In: Scientific Reports Jg. 9 (2019) Nr. 1, 18511
    Online Volltext: dx.doi.org/ (Open Access)
  • Möhlendick, Birte; Schmid, Kurt Werner; Siffert, Winfried
    The GNAS SNP c.393C>T (rs7121) as a marker for disease progression and survival in cancer
    In: Pharmacogenomics Jg. 20 (2019) Nr. 7, S. 553 - 562
    Online Volltext: dx.doi.org/
  • Hütter, Franz Korbinian; Horn, Peter; Siffert, Winfried
    Sex-specific association of a common GNAS polymorphism with self-reported cognitive empathy in healthy volunteers
    In: PLoS ONE Jg. 13 (2018) Nr. 10, S. e0206114
    Online Volltext: dx.doi.org/ (Open Access)
  • Klenke, Stefanie; Engler, Andrea; Ecker, Daniel; Ochsenfarth, Crista; Danowski, Nina; Peters, Jürgen; Siffert, Winfried; Frey, Ulrich
    The GRK2 Promoter Is Regulated by Early-Growth Response Transcription Factor EGR-1
    In: Basic and Clinical Pharmacology and Toxicology (BCPT) Jg. 123 (2018) Nr. 6, S. 660 - 669
    Online Volltext: dx.doi.org/ (Open Access)
  • Rahmel, Tim; Nowak, Hartmuth; Rump, Katharina; Siffert, Winfried; Peters, Jürgen; Adamzik, Michael
    The aquaporin 5 -1364A/C promoter polymorphism impacts on resolution of acute kidney injury in pneumonia evoked ARDS.
    In: PLoS ONE Jg. 13 (2018) Nr. 12, S. e0208582
    Online Volltext: dx.doi.org/ (Open Access)
  • Frey, Ulrich; Klenke, Stefanie; Mitchell, Anna; Knüfermann, Tim; Jakob, Heinz G.; Thielmann, Matthias Klaus; Siffert, Winfried; Peters, Jürgen
    GNAQ TT(-695/-694)GC Polymorphism Is Associated with Increased Gq Expression, Vascular Reactivity, and Myocardial Injury after Coronary Artery Bypass Surgery
    In: Anesthesiology Jg. 127 (2017) Nr. 1, S. 70 - 77
    Online Volltext: dx.doi.org/
  • Rump, Katharina; Unterberg, Matthias; Bergmann, Lars; Bankfalvi, Agnes; Menon, Anil; Schäfer, Simon; Scherag, Andre; Bazzi, Zainab; Siffert, Winfried; Peters, Jürgen; Adamzik, Michael
    AQP5-1364A/C polymorphism and the AQP5 expression influence sepsis survival and immune cell migration : a prospective laboratory and patient study
    In: Journal of Translational Medicine Jg. 14 (2016) Nr. 1, 321
    Online Volltext: dx.doi.org/ (Open Access)
  • Huetter, Franz Korbinian; Bachmann, Hagen Sjard; Reinders, Anette; Siffert, Doris; Stelmach, Patrick; Knop, Dietmar; Horn, Peter; Siffert, Winfried
    Association of a Common Oxytocin Receptor Gene Polymorphism with Self-Reported 'Empathic Concern' in a Large Population of Healthy Volunteers
    In: PLoS ONE Jg. 11 (2016) Nr. 7, S. e0160059
    Online Volltext: dx.doi.org/ (Open Access)
  • Wimberger, Pauline; Bankfalvi, Agnes; Schmid, Kurt Werner; Callies, Rainer; Kimmig, Rainer; Kuhlmann, J. D.; Siffert, Winfried; Bachmann, Hagen Sjard
    Caspase-8 Polymorphisms As Independent Prongostic Factors For Survival In Breast Cancer Patients
    In: International Journal of Gynecological Cancer Jg. 26 (2016) Nr. Suppl. 2, S. 30
    Online Volltext: dx.doi.org/
  • Wieneke, Heinrich; Svendsen, Jesper Hastrup; Lande, Jeffrey; Spencker, Sebastian; Martinez, Juan Gabriel; Strohmer, Bernhard; Toivonen, Lauri; Le Marec, Hervé; Garcia-Fernandez, F Javier; Corrado, Domenico; Huertas-Vazquez, Adriana; Uy-Evanado, Audrey; Rusinaru, Carmen; Reinier, Kyndaron; Foldesi, Csaba; Hulak, Wieslaw; Chugh, Sumeet S; Siffert, Winfried
    Polymorphisms in the GNAS Gene as Predictors of Ventricular Tachyarrhythmias and Sudden Cardiac Death : Results From the DISCOVERY Trial and Oregon Sudden Unexpected Death Study
    In: Journal of the American Heart Association Jg. 5 (2016) Nr. 12, S. e003905
    Online Volltext: dx.doi.org/ (Open Access)
  • Kuhlmann, J D; Bankfalvi, Agnes; Schmid, Kurt Werner; Callies, Rainer; Kimmig, Rainer; Wimberger, Pauline; Siffert, Winfried; Bachmann, Hagen Sjard
    Prognostic relevance of caspase 8 -652 6N InsDel and Asp302His polymorphisms for breast cancer
    In: BMC Cancer Jg. 16 (2016) S. 618
    Online Volltext: dx.doi.org/ (Open Access)
  • Rump, Katharina; Siffert, Winfried; Peters, Jürgen; Adamzik, Michael
    The Transcription Factor NMP4 Binds to the AQP5 Promoter and Is a Novel Transcriptional Regulator of the AQP5 Gene
    In: DNA and Cell Biology Jg. 35 (2016) Nr. 7, S. 322 - 327
    Online Volltext: dx.doi.org/
  • Lehnerdt, Götz; Bachmann, Hagen Sjard; Adamzik, Michael; Panic, Andrej; Köksal, E; Weller, Patrick; Lang, Stephan; Schmid, Kurt Werner; Siffert, Winfried; Bankfalvi, Agnes
    AQP1, AQP5, Bcl-2 and p16 in pharyngeal squamous cell carcinoma
    In: The Journal of Laryngology and Otology Jg. 129 (2015) Nr. 6, S. 580 - 586
    Online Volltext: dx.doi.org/
  • Heubner, Martin; Wimberger, Pauline; Kasimir-Bauer, Sabine; Singer, Bernhard B.; Ruf, Peter; Kimmig, Rainer; Siffert, Winfried
    Single nucleotide polymorphisms of the EpCAM-coding gene TACSTD1 in patients with ovarian cancer and their potential translational aspects
    In: Archives of Gynecology and Obstetrics Jg. 292 (2015) Nr. 6, S. 1367 - 1372
    Online Volltext: dx.doi.org/
  • Bachmann, Hagen Sjard; Wimberger, Pauline; Aminossadati, Behnaz; Schmalfeldt, Barbara; Burges, Alexander; Hillemanns, Peter; Huober, Jens B.; Wollschlaeger, Kerstin M.; Sehouli, Jalid; Siffert, Winfried; Kuhlmann, Jan Dominik; Kimmig, Rainer; Du Bois, Andreas; Meier, Werner
    The FNTB promoter polymorphism rs11623866 as a potential predictive biomarker for lonafarnib treatment of ovarian cancer patients
    In: British Journal of Clinical Pharmacology (BJCP) Jg. 80 (2015) Nr. 5, S. 1139 - 1148
    Online Volltext: dx.doi.org/ (Open Access)
  • Wieneke, Heinrich; Corrado, D.; Lande, J.; Fernandez, J. G.; Svendsen, J.; Le Marec, H.; Martinez, J. G.; Spencker, S.; Strohmer, B.; Toivonen, L.; Siffert, Winfried
    The role of genetic in ventricular tachyarrhythmia risk stratification : Primary results from the discovery trial
    In: Journal of the American College of Cardiology (JACC) Jg. 65 (2015) Nr. 10 Supplement, S. A270
    Online Volltext: dx.doi.org/ (Open Access)
  • Akdeli, Neval; Riemann, Kathrin; Westphal, Jana; Heß, Jochen A.; Siffert, Winfried; Bachmann, Hagen Sjard
    A 3′UTR polymorphism modulates mRNA stability of the oncogene and drug target Polo-like Kinase 1
    In: Molecular Cancer Jg. 13 (2014) 87
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Klenke, Stefanie; Frey, Ulrich; Siffert, Winfried; Peters, Jürgen; Engler, Andrea; Buschkamp, Kai; Rump, Katharina
    Characterization of the PLCB1 promoter and regulation by early growth response transcription factor EGR-1
    In: European Journal of Pharmacology Jg. 742 (2014) Nr. 5, S. 8 - 14
    Online Volltext: dx.doi.org/
  • Frey, Ulrich; Moebus, Susanne; Möhlenkamp, Stefan; Kälsch, Hagen; Bauer, Marcus; Lehmann, Nils; Nöthen, Markus; Mühleisen, Thomas W; Stang, Andreas; Erbel, Raimund; Jöckel, Karl-Heinz; Peters, Jürgen; Siffert, Winfried
    GNB3 gene 825 TT variant predicts hard coronary events in the population-based Heinz Nixdorf Recall study
    In: Atherosclerosis Jg. 237 (2014) Nr. 2, S. 437 - 442
    Online Volltext: dx.doi.org/
  • Alakus, Hakan; Bollschweiler, Elfriede H.; Hölscher, Hölscher, Arnulf H.; Warnecke-Eberz, Ute; Frazer, Kelly A.; Harismendy, Olivier; Lowy, Andrew M.; Mönig, Stefan P.; Eberz, Pascal M.; Maus, Martin K. H.; Drebber, Uta; Siffert, Winfried; Metzger, Ralf
    Homozygous GNAS 393C-Allele Carriers with Locally Advanced Esophageal Cancer Fail to Benefit from Platinum-Based Preoperative Chemoradiotherapy
    In: Annals of Surgical Oncology Jg. 21 (2014) Nr. 13, S. 4375 - 4382
    Online Volltext: dx.doi.org/
  • Schäfer, Simon; Gessner, Sophia; Scherag, Andre; Rump, Katharina; Frey, Ulrich; Siffert, Winfried; Westendorf, Astrid; Steinmann, Jörg; Peters, Jürgen; Adamzik, Michael
    Hydrocortisone Fails to Abolish NF-κB1 Protein Nuclear Translocation in Deletion Allele Carriers of the NFKB1 Promoter Polymorphism (-94ins/delATTG) and Is Associated with Increased 30-Day Mortality in Septic Shock
    In: PLoS ONE Jg. 9 (2014) Nr. 8, e104953
    Online Volltext: dx.doi.org/ (Open Access)
  • Heubner, MartinLeon; Wimberger, Pauline; Kasimir-Bauer, Sabine; Singer, Bernhard B.; Ruf, Peter; Kimmig, Rainer; Siffert, Winfried
    Single nucleotide polymorphism of the EpCAM-coding gene TACSTD1 in patients with ovarian cancer and their potential implications in clinical practice
    In: Journal of Clinical Oncology (JCO) Jg. 32 (2014) Nr. 15 Suppl., S. e16515
    Online Volltext: dx.doi.org/
  • Wimberger, Pauline; Bachmann, Hagen Sjard; Du Bois, A.; Kimmig, Rainer; Kuhlmann, J. D.; Siffert, Winfried; Sehoull, J.; Wollschlaeger, K.; Huober, J. B.; Hillemanns, P.; Burges, A.; Schmalfeldt, B.; Amlnossadatl, B.; Meier, W.
    The FNTB-609G>C polymorphism as a possible predictive factor for efficacy of lonafarnib-treatment? : Exploratory analysis of a randomized phase II clinical trial in stage IIb-IV ovarian cancer, treated with first-line platinum-based chemotherapy with or without lonafarnib
    In: Journal of Clinical Oncology (JCO) Jg. 32 (2014) Nr. 15 Suppl., S. e16534
    Online Volltext: dx.doi.org/
  • Heubner, Martin; Kimmig, Rainer; Aktas, Bahriye; Siffert, Winfried; Frey, Ulrich
    The haplotype of three polymorphisms in the SATB1 promoter region impacts survival in breast cancer patients
    In: Oncology Letters Jg. 7 (2014) Nr. 6, S. 2007 - 2012
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Rump, Katharina; Brendt, Peter; Frey, Ulrich; Schäfer, Simon; Siffert, Winfried; Peters, Jürgen; Adamzik, Michael
    Aquaporin 1 and 5 expression evoked by the β2 adrenoreceptor agonist terbutaline and lipopolysaccharide in mice and in the human monocytic cell line THP-1 is differentially regulated
    In: Shock Jg. 40 (2013) Nr. 5, S. 430 - 436
    Online Volltext: dx.doi.org/
  • Klenke, Stefanie; Siffert, Winfried; Frey, Ulrich
    Cloning and characterization of the GNA11 promoter and its regulation by early growth response 1
    In: Basic and Clinical Pharmacology and Toxicology (BCPT) Jg. 113 (2013) Nr. 5, S. 316 - 324
    Online Volltext: dx.doi.org/
  • El Hindy, Nicolai; Sandalcioglu, Ibrahim Erol; Sure, Ulrich; Siffert, Winfried; Zhu, Yuan; Lambertz, Nicole; Adamzik, Michael; Herring, Arne; Bankfalvi, Agnes
    Correlation of Aquaporin-1 Water Channel Protein Expression with Tumor Angiogenesis in Human Astrocytoma
    In: Anticancer Research Jg. 33 (2013) Nr. 2, S. 609 - 613
    Online Volltext
  • Danowski, Nina; Manthey, Iris; Jakob, Heinz G.; Siffert, Winfried; Peters, Jürgen; Frey, Ulrich
    Decreased expression of miR-133a but not of miR-1 is associated with signs of heart failure in patients undergoing coronary bypass surgery
    In: Cardiology Jg. 125 (2013) Nr. 2, S. 125 - 130
    Online Volltext: dx.doi.org/
  • Lambertz, Nicole; Hindy, Nicolai El; Adler, Cordula; Rump, Katharina; Adamzik, Michael; Keyvani, Kathy; Bankfalvi, Agnes; Siffert, Winfried; Sandalcioglu, Ibrahim Erol; Bachmann, Hagen Sjard
    Expression of aquaporin 5 and the AQP5 polymorphism A(-1364)C in association with peritumoral brain edema in meningioma patients
    In: Journal of Neuro-Oncology Jg. 112 (2013) Nr. 2, S. 297 - 305
    Online Volltext: dx.doi.org/
  • Siffert, Winfried
    Institutional profile : institute of pharmacogenetics at the university hospital essen
    In: Pharmacogenomics Jg. 14 (2013) Nr. 3, S. 241 - 243
    Online Volltext: dx.doi.org/
  • Plicht, Björn; Konorza, Thomas; Kahlert, Philipp; Al-Rashid, Fadi; Kälsch, Hagen; Janosi, Rolf Alexander; Buck, Thomas; Bachmann, Hagen Sjard; Siffert, Winfried; Heusch, Gerd; Erbel, Raimund
    Risk factors for thrombus formation on the amplatzer cardiac plug after left atrial appendage occlusion
    In: JACC Cardiovascular Interventions Jg. 6 (2013) Nr. 6, S. 606 - 613
    Online Volltext: dx.doi.org/
  • Adamzik, Michael; Schäfer, Simon; Frey, Ulrich; Becker, Arne; Kreuzer, Maximiliane; Winning, Sandra; Frede, Stilla; Steinmann, Jörg; Fandrey, Joachim; Zacharowski, Kai; Siffert, Winfried; Peters, Jürgen; Hartmann, Matthias
    The NFKB1 promoter polymorphism (-94ins/delATTG) alters nuclear translocation of NF-κB1 in monocytes after lipopolysaccharide stimulation and is associated with increased mortality in sepsis.
    In: Anesthesiology Jg. 118 (2013) Nr. 1, S. 123 - 133
    Online Volltext: dx.doi.org/
  • El Hindy, Nicolai; Sandalcioglu, Ibrahim Erol; Adamzik, Michael; Peters, Jürgen; Sure, Ulrich; Siffert, Winfried; Bankfalvi, Agnes; Frey, Ulrich; Zhu, Yuan; Lambertz, Nicole; Rump, Katharina
    The functional Aquaporin 1 −783G/C-polymorphism is associated with survival in patients with glioblastoma multiforme
    In: Journal of Surgical Oncology Jg. 108 (2013) Nr. 7, S. 492 - 498
    Online Volltext: dx.doi.org/
  • Bachmann, Hagen Sjard; Siffert, Winfried; Jansen, K.; Michalik, C.; Moll, A.; Dupke, S.; Koppe, S.; Harrer, T.; Rausch, M.; Brockmeyer, N. H.; Skaletz-Rorowski, A.; Competence Network For HIV AIDS
    HCV-HIV-coinfected Patients of the Competence Network for HIV/AIDS Cohort : Impact of IL28B Polymorphisms on Sustained Virological Response
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) Jg. 10 (2012) Nr. Suppl. 3, S. 36 - 37
  • Arweiler-Harbeck, Diana; Saidi, F.; Lang, Stephan; Peters, Jürgen; Siffert, Winfried; Adamzik, Michael
    The -1364A/C Aquaporin 5 Gene Promoter Polymorphism Is Not Associated with Menière’s Disease
    In: ISRN Otolaryngology (2012) S. 706896
    Online Volltext: dx.doi.org/
  • Dusse, Fabian; Frey, Ulrich; Bilalic, Adisa; Dirkmann, Daniel; Görlinger, Klaus; Siffert, Winfried; Peters, Jürgen
    The GNB3 C825T polymorphism influences platelet aggregation in human whole blood
    In: Pharmacogenetics and Genomics Jg. 22 (2012) Nr. 1, S. 43 - 49
    Online Volltext: dx.doi.org/
  • Bachmann, Hagen Sjard; Akdeli, N.; Heukamp, L.; Schulte, J.; Siffert, Winfried
    The small molecule Bcl-2/Mcl-1 inhibitor TW-37 shows single-agent cytotoxicity in neuroblastoma cell lines
    In: Naunyn-Schmiedeberg's Archives of Pharmacology Jg. 385 (2012) Nr. Suppl. 1, S. 7 - 7
  • Klenke, Stefanie; Siffert, Winfried; Frey, Ulrich
    A novel aspect of GNAS imprinting : Higher maternal expression of Gαs in human lymphoblasts, peripheral blood mononuclear cells, mammary adipose tissue, and heart
    In: Molecular and Cellular Endocrinology Jg. 341 (2011) Nr. 1-2, S. 63 - 70
    Online Volltext: dx.doi.org/
  • Adamzik, Michael; Frey, Ulrich H.; Möhlenkamp, Stephan; Scherag, Andre; Waydhas, Christian; Marggraf, Günther; Dammann, Marc; Steinmann, Jörg; Siffert, Winfried; Peters, Jürgen
    Aquaporin 5 gene promoter -1364A/C polymorphism associated with 30-day survival in severe sepsis
    In: Anesthesiology Jg. 114 (2011) Nr. 4, S. 912 - 917
    Online Volltext: dx.doi.org/ (Open Access)
  • El Hindy, Nicolai; Sandalcioglu, Ibrahim Erol; Siffert, Winfried; Zhu, Yuan; Sure, Ulrich; Worm, Karl; Nückel, Holger; Adamzik, Michael; Lambertz, Nicole; Bachmann, Hagen Sjard
    Association of the CC genotype of the regulatory BCL2 promoter polymorphism (−938C>A) with better 2-year survival in patients with glioblastoma multiforme
    In: Journal of Neurosurgery (JNS) Jg. 114 (2011) Nr. 6, S. 1631 - 1639
    Online Volltext: dx.doi.org/
  • Klenke, Stefanie; Siffert, Winfried; Frey, Ulrich
    Characterization of the GNA11 promoter and regulation by Egr-1
    In: Naunyn-Schmiedeberg's Archives of Pharmacology Jg. 383 (2011) Nr. Suppl. 1, S. 29 - 30
  • Frey, Ulrich; Kottenberg, Eva; Kamler, Markus; Leineweber, Kirsten; Manthey, I.; Heusch, Gerd; Siffert, Winfried; Peters, Jürgen
    Genetic interactions in the β-adrenoceptor/G-protein signal transduction pathway and survival after coronary artery bypass grafting : a pilot study
    In: British Journal of Anaesthesia (BJA) Jg. 107 (2011) Nr. 6, S. 869 - 878
    Online Volltext: dx.doi.org/ (Open Access)
  • Holtmann, G.; Van Rensburg, C.; Schwan, T.; Sander, P.; Siffert, Winfried
    Improvement of Non-Steroidal Anti-Inflammatory Drug-Induced Gastrointestinal Symptoms during Proton Pump Inhibitor Treatment : Are G-Protein β3 Subunit Genotype, Helicobacter pylori Status, and Environmental Factors Response Modifiers?
    In: Digestion Jg. 84 (2011) Nr. 4, S. 289 - 298
    Online Volltext: dx.doi.org/
  • Bachmann, Hagen Sjard; Lieb, B.; Bonnet, Udo; Specka, M.; Augener, S.; Siffert, Winfried; Scherbaum, Norbert
    Influence of the 393T>C Polymorphism of the GNAS1 Gene on the Intensity of Opiate Withdrawal
    In: Pharmacopsychiatry Jg. 44 (2011) Nr. 4, S. 159 - 160
    Online Volltext: dx.doi.org/
  • Eisenhardt, Andreas; Scherag, Andre; Jöckel, Karl-Heinz; Reis, Henning; Rübben, Herbert; Siffert, Winfried
    Lack of Association of the Genotype in the GNAS Fok I Polymorphism and Prostate Cancer
    In: Urologia Internationalis Jg. 87 (2011) Nr. 1, S. 80 - 86
    Online Volltext: dx.doi.org/
  • Bachmann, Hagen Sjard; Heukamp, Lucas C.; Schmitz, Klaus Jürgen; Hilburn, Caroline F.; Kahl, Philip; Buettner, Reinhard; Nückel, Holger; Eisenhardt, Andreas; Rübben, Herbert; Schmid, Kurt Werner; Siffert, Winfried; Eggert, Angelika; Schramm, Alexander; Schulte, Johannes
    Regulatory BCL2 promoter polymorphism (-938C>A) is associated with adverse outcome in patients with prostate carcinoma
    In: International Journal of Cancer Jg. 129 (2011) Nr. 10, S. 2390 - 2399
    Online Volltext: dx.doi.org/
  • El Hindy, Nicolai; Sandalcioglu, Ibrahim Erol; Siffert, Winfried; Sure, Ulrich; Zhu, Yuan; Adamzik, Michael; Frey, Ulrich; Lambertz, Nicole
    Role of the GNAS1 T393C polymorphism in patients with glioblastoma multiforme
    In: Journal of Clinical Neuroscience Jg. 18 (2011) Nr. 11, S. 1495 - 1499
    Online Volltext: dx.doi.org/
  • Klenke, Stefanie; Siffert, Winfried
    SNPs in genes encoding G proteins in pharmacogenetics
    In: Pharmacogenomics Jg. 12 (2011) Nr. 5, S. 633 - 654
    Online Volltext: dx.doi.org/
  • Klenke, Stefanie; Kussmann, Martin; Siffert, Winfried
    The GNB3 C825T polymorphism as a pharmacogenetic marker in the treatment of hypertension, obesity, and depression
    In: Pharmacogenetics and Genomics Jg. 21 (2011) Nr. 9, S. 594 - 606
    Online Volltext: dx.doi.org/
  • Adamzik, Michael; Schaefer, S.; Frey, Ulrich; Becker, A.; Kreutzer, M.; Winning, S.; Frede, Stilla; Steinmann, Jörg; Fandrey, Joachim; Zacharowski, K.; Siffert, Winfried; Peters, Jürgen; Hartmann, Matthias
    The NFKB1 promoter polymorphism (94ins/delATTG) alters nuclear translocation of NF-KB1 in monocytes following lipopolysaccharide stimulation and is associated with increased mortality in sepsis
    In: Infection - A Journal of Infectious Disease Jg. 39 (2011) Nr. Suppl. 2, S. 102
  • Grabellus, Florian; Worm, Karl; Sheu, Sien-Yi; Siffert, Winfried; Schmid, Kurt Werner; Bachmann, Hagen Sjard
    The prevalence of the c-kit exon 10 variant, M541L, in aggressive fibromatosis does not differ from the general population
    In: Journal of Clinical Pathology: JCP Online Jg. 64 (2011) Nr. 11, S. 1021 - 1024
    Online Volltext: dx.doi.org/
  • Klenke, Stefanie; Tan, Susanne; Hahn, Susanne; Mann, Klaus; Hauner, Hans; Manthey, Iris; Peters, Jürgen; Siffert, Winfried; Frey, Ulrich
    A functional GNAQ promoter haplotype is associated with altered Gq expression and with insulin resistance and obesity in women with polycystic ovary syndrome
    In: Pharmacogenetics and Genomics Jg. 20 (2010) Nr. 8, S. 476 - 484
    Online Volltext: dx.doi.org/
  • Khandanpour, Cyrus; Thiede, Christian; Valk, Peter J.; Sharif-Askari, Ehssan; Nückel, Holger; Lohmann, Dietmar; Horsthemke, Bernhard; Siffert, Winfried; Neubauer, Andreas; Grzeschik, Karl-Heinz; Bloomfield, Clara D.; Marcucci, Guido; Maharry, Kati; Slovak, Marilyn L.; van der Reijden, Bert A.; Jansen, Joop H.; Schackert, Hans K.; Afshar, Khashayar; Schnittger, Susanne; Peeters, Justine K.; Kroschinsky, Frank; Ehninger, Gerhard; Lowenberg, Bob; Dührsen, Ulrich; Möröy, Tarik
    A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia
    In: Blood Jg. 115 (2010) Nr. 12, S. 2462 - 2472
    Online Volltext: dx.doi.org/
  • Otterbach, Friedrich; Callies, Rainer; Adamzik, Michael; Kimmig, Rainer; Siffert, Winfried; Schmid, Kurt Werner; Bankfalvi, Agnes
    Aquaporin 1 (AQP1) expression is a novel characteristic feature of a particularly aggressive subgroup of basal-like breast carcinomas
    In: Breast Cancer Research and Treatment Jg. 120 (2010) Nr. 1, S. 67 - 76
    Online Volltext: dx.doi.org/
  • El Hindy, Nicolai; Adamzik, Michael; Lambertz, Nicole; Bachmann, Hagen Sjard; Worm, Karl; Egensperger, Rupert; Frey, Ulrich; Asgari, Siamak; Sure, Ulrich; Siffert, Winfried; Sandalcioglu, Erol
    Association of the GNB3 825T-allele with better survival in patients with glioblastoma multiforme
    In: Journal of Cancer Research and Clinical Oncology Jg. 136 (2010) Nr. 9, S. 1423 - 1429
    Online Volltext: dx.doi.org/
  • Frey, Ulrich; Fritz, A.; Rotterdam, Sebastian; Schmid, Kurt Werner; Potthoff, Anja; Altmeyer, Peter; Siffert, Winfried; Brockmeyer, Norbert
    GNAS1 T393C polymorphism and disease progression in patients with malignant melanoma
    In: European Journal of Medical Research Jg. 15 (2010) Nr. 10, S. 422 - 427
    Online Volltext: dx.doi.org/ (Open Access)
  • Bachmann, Hagen Sjard; Hanenkamp, Sandra; Kornacki, Bartlomiej; Frey, Ulrich; Bau, Maja; Siffert, Winfried; Wedemeyer, Christian
    Gender‐dependent association of the GNAS1 T393C polymorphism with early aseptic loosening after total hip arthroplasty : Reply : Letters to the Editors
    In: Journal of Orthopaedic Research Jg. 28 (2010) Nr. 9, S. 1258
    Online Volltext: dx.doi.org/
  • Kussmann, Martin; Krause, Lutz; Siffert, Winfried
    Nutrigenomics : Where are we with genetic and epigenetic markers for disposition and susceptibility?
    In: Nutrition Reviews Jg. 68 (2010) Nr. 11 Suppl. 1, S. 38 - S47
    Online Volltext: dx.doi.org/
  • Wieneke, Heinrich; Spencker, Sebastian; Svendsen, Jesper Hastrup; Martinez, Juan Gabriel; Strohmer, Bernhard; Toivonen, Lauri; Le Marec, Hervé; Garcia, Javier; Kaup, Bernd; Soykan, Orhan; Corrado, Domenico; Siffert, Winfried
    Polymorphisms associated with ventricular tachyarrhythmias : Rationale, design, and endpoints of the 'diagnostic data influence on disease management and relation of genomics to ventricular tachyarrhythmias in implantable cardioverter/defibrillator patients (DISCOVERY)' study
    In: EP Europace Jg. 12 (2010) Nr. 3, S. 424 - 429
    Online Volltext: dx.doi.org/ (Open Access)
  • Arweiler-Harbeck, Diana; Öztürk, Ender; Bankfalvi, Agnes; Lang, Stephan; Siffert, Winfried; Schmid, Kurt Werner; Peters, Jürgen; Adamzik, Michael
    Posttonsillectomy hemorrhage : Blame on surgeons or genes?
    In: Laryngoscope Jg. 120 (2010) Nr. 9, S. 1784 - 1787
    Online Volltext: dx.doi.org/
  • Fingas, Christian; Katsounas, Antonios; Kahraman, Alisan; Siffert, Winfried; Jochum, Christoph; Gerken, Guido; Nckel, Holger; Canbay, Aliekber; Nückel, Holger
    Prognostic assessment of three single-nucleotide polymorphisms (GNB3 825C>T, BCL2-938C>A, MCL1-386C>G) in extrahepatic cholangiocarcinoma
    In: Cancer Investigation Jg. 28 (2010) Nr. 5, S. 472 - 478
    Online Volltext: dx.doi.org/
  • Leineweber, Kirsten; Frey, Ulrich; Tenderich, Gero; Toliat, Mohammad Reza; Zittermann, Armin; Nürnberg, Peter; Körfer, Reiner; Siffert, Winfried; Heusch, Gerd
    The Arg16Gly-β2-adrenoceptor single nucleotide polymorphism : exercise capacity and survival in patients with end-stage heart failure
    In: Naunyn-Schmiedeberg's Archives of Pharmacology Jg. 382 (2010) Nr. 4, S. 357 - 365
    Online Volltext: dx.doi.org/
  • Heubner, Martin; Wimberger, Pauline; Riemann, Kathrin; Kasimir-Bauer, Sabine; Otterbach, Friedrich; Kimmig, Rainer; Siffert, Winfried
    The CYP1A1 Ile462Val polymorphism and platinum resistance of epithelial ovarian neoplasms
    In: Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics Jg. 18 (2010) Nr. 7, S. 343 - 347
    Online Volltext: dx.doi.org/
  • Bachmann, Hagen Sjard; Novotny, Jürgen; Sixt, Stephan Urs; Liebisch, Peter; Frey, Ulrich; Dührsen, Ulrich; Siffert, Winfried; Nückel, Holger
    The G-Allele of the PSMA6-8C>G polymorphism is associated with poor outcome in multiple myeloma independently of circulating proteasome serum levels
    In: European Journal of Haematology Jg. 85 (2010) Nr. 2, S. 108 - 113
    Online Volltext: dx.doi.org/
  • Riemann, Kathrin; Struwe, Henrike; Alakus, Hakan; Obermaier, Brigitte; Schmitz, Klaus Jürgen; Schmid, Kurt Werner; Siffert, Winfried
    Association of GNB4 intron-1 haplotypes with survival in patients with UICC stage III and IV colorectal carcinoma.
    In: Anticancer Research Jg. 29 (2009) Nr. 4, S. 1271 - 1274
  • Heubner, Martin; Wimberger, Pauline; Otterbach, Friedrich; Kasimir-Bauer, Sabine; Siffert, Winfried; Kimmig, Rainer; Nückel, Holger
    Association of the AA genotype of the BCL2 (-938C>A) promoter polymorphism with better survival in ovarian cancer
    In: The International Journal of Biological Markers (IJBM) Jg. 24 (2009) Nr. 4, S. 223 - 229
    Online Volltext: dx.doi.org/
  • Alakus, Hakan; Mönig, Stefan P.; Warnecke-Eberz, Ute; Alakus, Gül; Winde, Günther; Drebber, Uta; Schmitz, Klaus Jürgen; Schmid, Kurt Werner; Riemann, Kathrin; Siffert, Winfried; Bollschweiler, Elfriede; Hölscher, Arnulf H.; Metzger, Ralf
    Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer
    In: World Journal of Gastroenterology Jg. 15 (2009) Nr. 48, S. 6061 - 6067
    Online Volltext: dx.doi.org/ (Open Access)
  • Zenz, Thorsten; Benner, Axel; Dührsen, Ulrich; Dürig, Jan; Döhner, Hartmut; Siffert, Winfried; Stilgenbauer, Stephan; Nückel, Holger
    BCL2-938C>A polymorphism and disease progression in chronic lymphocytic leukemia
    In: Leukemia and Lymphoma Jg. 50 (2009) Nr. 11, S. 1837 - 1842
  • Bachmann, Hagen Sjard; Rübben, Herbert; Schmid, Kurt Werner; Siffert, Winfried; Riemann, Kathrin
    DNA repair gene XRCC1 polymorphisms and outcome of renal cell carcinoma in Caucasian patients
    In: Anticancer Research Jg. 29 (2009) Nr. 12, S. 5131 - 5135
  • Nückel, Holger; Collins, Christa H.; Sellmann, Ludger; Dürig, Jan; Siffert, Winfried; Dührsen, Ulrich
    FCRL2 mRNA expression is inversely associated with clinical progression in chronic lymphocytic leukemia
    In: European Journal of Haematology Jg. 83 (2009) Nr. 6, S. 541 - 549
    Online Volltext: dx.doi.org/
  • Heubner, Martin; Wimberger, Pauline; Kasimir-Bauer, Sabine; Otterbach, Friedrich; Kimmig, Rainer; Siffert, Winfried
    The AA genotype of a L1C G842A polymorphism is associated with an increased risk for ovarian cancer.
    In: Anticancer Research Jg. 29 (2009) Nr. 8, S. 3449 - 3452
  • Heubner, Martin; Riemann, Kathrin; Otterbach, Friedrich; Kimmig, Rainer; Kasimir-Bauer, Sabine; Siffert, Winfried; Wimberger, Pauline
    The haplotype of two FSHR polymorphisms in ovarian cancer : A potential role of ethnology in risk modification
    In: Gynecologic Oncology Jg. 112 (2009) Nr. 3, S. 486 - 489
    Online Volltext: dx.doi.org/
  • Lehnerdt, Götz; Franz, P.; Bankfalvi, Agnes; Grehl, S.; Kelava, A.; Nückel, Holger; Lang, Stephan; Schmid, Kurt Werner; Siffert, Winfried; Bachmann, Hagen Sjard
    The regulatory BCL2 promoter polymorphism (-938C>A) is associated with relapse and survival of patients with oropharyngeal squamous cell carcinoma
    In: Annals of Oncology Jg. 20 (2009) Nr. 6, S. 1094 - 1099
    Online Volltext: dx.doi.org/ (Open Access)
  • Frey, Ulrich; Hauner, Hans; Jöckel, Karl-Heinz; Manthey, Iris; Brockmeyer, Norbert; Siffert, Winfried
    A novel promoter polymorphism in the human gene GNAS affects binding of transcription factor upstream stimulatory factor 1, Gαs protein expression and body weight regulation
    In: Pharmacogenetics and Genomics Jg. 18 (2008) Nr. 2, S. 141 - 151
    Online Volltext: dx.doi.org/
  • Adamzik, Michael; Frey, Ulrich; Bitzer, Kathrin; Jakob, Heinz G.; Baba, Hideo Andreas; Schmieder, Roland E.; Schneider, Markus P.; Heusch, Gerd; Peters, Jürgen; Siffert, Winfried
    A novel-1364A/C aquaporin 5 gene promoter polymorphism influences the responses to salt loading of the renin-angiotensin-aldosterone system and of blood pressure in young healthy men
    In: Basic Research in Cardiology Jg. 103 (2008) Nr. 6, S. 598 - 610
    Online Volltext: dx.doi.org/
  • Lehnerdt, Götz; Franz, Peter; Bankfalvi, Agnes; Grehl, Sara; Jahnke, Klaus; Lang, Stephan; Schmid, Kurt Werner; Siffert, Winfried; Frey, Ulrich
    Association study of the G-protein β3 subunit C825T polymorphism with disease progression an overall survival in patients with head and neck squamous cell carcinoma
    In: Cancer Epidemiology, Biomarkers & Prevention Jg. 17 (2008) Nr. 11, S. 3203 - 3207
    Online Volltext: dx.doi.org/ (Open Access)
  • Riemann, Kathrin; Struwe, Henrike; Eisenhardt, Andreas; Obermaier, Brigitte; Schmid, Kurt Werner; Siffert, Winfried
    Characterization of intron-1 haplotypes of the G protein β4 subunit gene : Association with survival and progression in patients with urothelial bladder carcinoma
    In: Pharmacogenetics and Genomics Jg. 18 (2008) Nr. 11, S. 999 - 1008
    Online Volltext: dx.doi.org/
  • Adamzik, Michael; Frey, Ulrich; Riemann, Kathrin; Sixt, Stephan Urs; Lehmann, Nils; Siffert, Winfried; Peters, Jürgen
    Factor v Leiden mutation is associated with improved 30-day survival in patients with acute respiratory distress syndrome
    In: Critical Care Medicine Jg. 36 (2008) Nr. 6, S. 1776 - 1779
    Online Volltext: dx.doi.org/
  • Lehnerdt, Götz; Franz, Peter; Zaqoul, Anwar; Schmitz, Klaus Jürgen; Grehl, Sara; Lang, Stephan; Schmid, Kurt Werner; Siffert, Winfried; Jahnke, Klaus; Frey, Ulrich
    Overall and relapse-free survival in oropharyngeal and hypopharyngeal squamous cell carcinoma are associated with genotypes of T393C polymorphism of the GNAS1 gene
    In: Clinical Cancer Research Jg. 14 (2008) Nr. 6, S. 1753 - 1758
    Online Volltext: dx.doi.org/ (Open Access)
  • Lehnerdt, Götz; Franz, Peter; Winterhoff, Sebastian M.; Bankfalvi, Agnes; Grehl, Sara; Lang, Stephan; Schmid, Kurt Werner; Siffert, Winfried; Jahnke, Klaus; Frey, Ulrich
    The GNAS1 T393C polymorphism predicts survival in patients with advanced squamous cell carcinoma of the larynx
    In: Laryngoscope Jg. 118 (2008) Nr. 12, S. 2172 - 2176
    Online Volltext: dx.doi.org/
  • Nückel, Holger; Frey, Ulrich; Bau, Maja; Sellmann, Ludger; Stanelle, Jens; Dürig, Jan; Jöckel, Karl-Heinz; Dührsen, Ulrich; Siffert, Winfried
    Association of a novel regulatory polymorphism (-938C>A) in the BCL2 gene promoter with disease progression and survival in chronic lymphocytic leukemia
    In: Blood Jg. 109 (2007) Nr. 1, S. 290 - 297
    Online Volltext: dx.doi.org/
  • Riemann, Kathrin; Adamzik, Michael; Frauenrath, Stefan; Egensperger, Rupert; Schmid, Kurt Werner; Brockmeyer, Norbert H.; Siffert, Winfried
    Comparison of manual and automated nucleic acid extraction from whole-blood samples
    In: Journal of Clinical Laboratory Analysis Jg. 21 (2007) Nr. 4, S. 244 - 248
    Online Volltext: dx.doi.org/ (Open Access)
  • Schmitz, Klaus Jürgen; Langy, Hauke; Frey, Ulrich; Sotiropoulos, Georgios; Wohlschläger, Jeremias; Reis, Henning; Takeda, Atsushi; Siffert, Winfried; Schmid, Kurt Werner; Baba, Hideo Andreas
    GNAS1 T393C polymorphism is associated with clinical course in patients with intrahepatic cholangiocarcinoma
    In: Neoplasia: An International Journal for Oncology Research Jg. 9 (2007) Nr. 2, S. 159 - 165
    Online Volltext: dx.doi.org/ (Open Access)
  • Bachmann, Hagen Sjard; Otterbach, Friedrich; Callies, Rainer; Nückel, Holger; Bau, Maja; Schmid, Kurt Werner; Siffert, Winfried; Kimmig, Rainer
    The AA genotype of the regulatory BCL2 promoter polymorphism (-938C>A) is associated with a favorable outcome in lymph node negative invasive breast cancer patients
    In: Clinical Cancer Research Jg. 13 (2007) Nr. 19, S. 5790 - 5797
    Online Volltext: dx.doi.org/ (Open Access)
  • Sheu, Sien-Yi; Handke, S.; Bröcker-Preuß, Martina; Görges, Rainer; Frey, Ulrich; Ensinger, C.; Öfner, D.; Farid, N.R.; Siffert, Winfried; Schmid, Kurt Werner
    The C allele of the GNB3 C825T polymorphism of the G protein β3-subunit is associated with an increased risk for the development of oncocytic thyroid tumours
    In: The Journal of Pathology Jg. 211 (2007) Nr. 1, S. 60 - 66
    Online Volltext: dx.doi.org/
  • Otterbach, Friedrich; Callies, Rainer; Frey, Ulrich; Schmitz, Klaus Jürgen; Wreczycki, Christof; Kimmig, Rainer; Siffert, Winfried; Schmid, Kurt Werner
    The T393C polymorphism in the gene GNAS1 of G protein is associated with survival of patients with invasive breast carcinoma
    In: Breast Cancer Research and Treatment Jg. 105 (2007) Nr. 3, S. 311 - 317
    Online Volltext: dx.doi.org/
  • Nückel, Holger; Frey, Ulrich; Sellmann, Ludger; Bau, M.; Dürig, Jan; Dührsen, Ulrich; Siffert, Winfried
    Bax gene G(-248)A promoter polymorphism and chronic lymphocytic leukemia: lack of association with incidence, disease stage and progression-free survival
    In: Leukemia Jg. 20 (2006) Nr. 4, S. 724
    Online Volltext: dx.doi.org/
  • Riemann, Kathrin; Becker, Lucie; Struwe, Henrike; Nückel, Holger; Dührsen, Ulrich; Alakus, Hakan; Winde, Günter; Neuhäuser, Markus; Rübben, Herbert; Schmitz, Klaus Jürgen; Wohlschläger, Jeremias; Schmid, Kurt Werner; Siffert, Winfried
    No association of the NFKB1 insertion/deletion promoter polymorphism with survival in colorectal and renal cell carcinoma as well as disease progression in B-cell chronic lymphocytic leukemia
    In: Pharmacogenetics and Genomics Jg. 16 (2006) Nr. 11, S. 783 - 788
    Online Volltext: dx.doi.org/
  • Frey, Ulrich; Nückel, Holger; Sellmann, Ludger; Siemer, Dörte; Küppers, Ralf; Siemer, Dörte; Küppers, Ralf; Dürig, Jan; Dührsen, Ulrich; Siffert, Winfried
    The GNAS1 T393C polymorphism is associated with disease progression and survival in chronic lymphocytic leukemia
    In: Clinical Cancer Research Jg. 12 (2006) Nr. 19, S. 5686 - 5692
    Online Volltext: dx.doi.org/
  • Frey, Ulrich; Lümmen, Gerd; Jäger, Tobias; Jöckel, Karl-Heinz; Schmid, Kurt Werner; Rübben, Herbert; Müller, Norbert; Siffert, Winfried; Eisenhardt, Andreas
    The GNAS1 T393C polymorphism predicts survival in patients with clear cell renal cell carcinoma
    In: Clinical Cancer Research Jg. 12 (2006) Nr. 3, S. 759 - 763
    Online Volltext: dx.doi.org/ (Open Access)
  • Sheu, Sien-Yi; Görges, Rainer; Ensinger, Christian; Öfner, Dietmar; Farid, Nadir R.; Siffert, Winfried; Schmid, Kurt Werner
    Different genotype distribution of the GNB3 C825T polymorphism of the G protein β3 subunit in adenomas and differentiated thyroid carcinomas of follicular cell origin
    In: The Journal of Pathology Jg. 207 (2005) Nr. 4, S. 430 - 435
    Online Volltext: dx.doi.org/
  • Frey, Ulrich; Alakus, Hakan; Wohlschläger, Jeremias; Schmitz, Klaus Jürgen; Winde, Günther; Van Calker, Hans G.; Jöckel, Karl-Heinz; Siffert, Winfried; Schmid, Kurt Werner
    GNAS1 T393C polymorphism and survival in patients with sporadic colorectal cancer
    In: Clinical Cancer Research Jg. 11 (2005) Nr. 14, S. 5071 - 5077
    Online Volltext: dx.doi.org/ (Open Access)
  • Brockmeyer, N H; Potthoff, A; Kasper, A; Nabring, C; Jöckel, Karl-Heinz; Siffert, Winfried
    GNB3 C825T polymorphism and response to anti-retroviral combination therapy in HIV-1-infected patients--a pilot study
    In: European Journal of Medical Research Jg. 10 (2005) Nr. 11, S. 489 - 494
  • Frey, Ulrich; Eisenhardt, Andreas; Lümmen, Gerd; Rübben, Herbert; Jöckel, Karl-Heinz; Schmid, Kurt Werner; Siffert, Winfried
    The T393C polymorphism of the Gαs gene (GNAS1) is a novel prognostic marker in bladder cancer
    In: Cancer Epidemiology, Biomarkers & Prevention Jg. 14 (2005) Nr. 4, S. 871 - 877
    Online Volltext: dx.doi.org/ (Open Access)
  • Holtmann, Gerald; Siffert, Winfried; Haag, Sebastian; Mueller, Norbert; Langkafel, Mathias; Senf, Wolfgang; Zotz, Rainer; Talley, Nicholas J.
    G-Protein β3 Subunit 825 CC Genotype Is Associated with Unexplained (Functional) Dyspepsia
    In: Gastroenterology Jg. 126 (2004) Nr. 4, S. 971 - 979
    Online Volltext: dx.doi.org/
  • Geller, Frank; Reichwald, Kathrin; Dempfle, Astrid; Illig, Thomas; Vollmert, Caren; Herpertz, Stephan; Siffert, Winfried; Platzer, Matthias; Hess, Claudia; Gudermann, Thomas; Biebermann, Heike; Wichmann, H.-Erich; Schäfer, Helmut; Hinney, Anke; Hebebrand, Johannes
    Melanocortin-4 Receptor Gene Variant I103 Is Negatively Associated with Obesity
    In: American Journal of Human Genetics Jg. 74 (2004) Nr. 3, S. 572 - 581
    Online Volltext: dx.doi.org/ (Open Access)
  • Nückel, Holger; Frey, Ulrich; Dürig, Jan; Dührsen, Ulrich; Siffert, Winfried
    Methylenetetrahydrofolate reductase (MTHFR) gene 677C>T and 1298A>C polymorphisms are associated with differential apoptosis of leukemic B cells in vitro and disease progression in chronic lymphocytic leukemia
    In: Leukemia Jg. 18 (2004) Nr. 11, S. 1816 - 1823
    Online Volltext: dx.doi.org/
  • Frey, Ulrich; Nückel, Holger; Dobrev, Dobromir; Manthey, Iris; Sandalcioglu, Erol; Eisenhardt, Andreas; Worm, Karl; Hauner, Hans; Siffert, Winfried
    Quantification of G protein Gαs subunit splice variants in different human tissues and cells using pyrosequencing
    In: Gene Expression Jg. 12 (2004) Nr. 2, S. 69 - 81
    Online Volltext: dx.doi.org/ (Open Access)
  • Nückel, Holger; Frey, Ulrich; Dürig, Jan; Dührsen, Ulrich; Siffert, Winfried; Aral, Nese
    The CC genotype of the C825T polymorphism of the G protein beta3 gene (GNB3) is associated with a high relapse rate in patients with chronic lymphocytic leukaemia
    In: Leukemia & Lymphoma Jg. 44 (2003) Nr. 10, S. 1739 - 1743
    Online Volltext: dx.doi.org/

    • Abstracts

  • Moehlendick, B.; Ciuciulkaite, I.; Elsner, C.; Wagner, B.; Dittmer, Ulf; Siffert, Winfried;
    Individuals with weaker humoral response after second booster vaccination are prone to SARS-CoV-2 Omicron BA.5 infections
    8th German Pharm-Tox Summit 2023, 06.-09.03.2023, Ulm,
    In: Naunyn-Schmiedeberg's Archives of Pharmacology Jg. 396 (2023) Nr. Supplement 1: 8th German Pharm-Tox Summit 2023 Abstracts of the 89. Jahrestagung der Deutschen Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie (DGPT) in Zusammenarbeit mit der AGAH, S. S5
    Online Volltext: dx.doi.org/ (Open Access)
  • Moehlendick, B.; Ting, S.; Schmid, Kurt Werner; Siffert, Winfried;
    The single nucleotide polymorphism rs7121 in the gene GNAS as a biomarker for tumor progression and poor survival in intrahepatic cholangiocellular carcinoma patients
    8th German Pharm-Tox Summit 2023, 06.-09.03.2023, Ulm,
    In: Naunyn-Schmiedeberg's Archives of Pharmacology Jg. 396 (2023) Nr. Supplement 1: 8th German Pharm-Tox Summit 2023 Abstracts of the 89. Jahrestagung der Deutschen Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie (DGPT) in Zusammenarbeit mit der AGAH, S. S46
    Online Volltext: dx.doi.org/ (Open Access)
  • Brune, Bastian; Korth, Johannes; Dolff, Sebastian; Wilde, Benjamin; Siffert, Winfried; Kribben, Andreas; Witzke, Oliver
    Role of the Endothelin System in the Interactions of the Vasopressor Systems in Vivo in Men : Importance of Genetic Host Factors
    In: Nephrology Dialysis Transplantation (NDT) Jg. 36 (2021) Nr. Supplement_1,
    Online Volltext: dx.doi.org/
  • Friebus-Kardash, Justa; Nela, E.; Moehlendick, B.; Heinemann, Falko M.; Heinold, Andreas; Kribben, Andreas; Siffert, Winfried; Eisenberger, Ute
    Development of de Novo Anti-HLA-DSA in renaö transplant patients depends on CYP3A5 genotype
    In: Transplant International Jg. 33 (2020) Nr. S2, Special Issue: Abstracts of the 29th Annual Meeting of the German Transplantation Society, Cologne, Germany, 15–17 October 2020, S. 10 - 11
    Online Volltext: dx.doi.org/ (Open Access)
  • Stein, G.; Stelmach, Patrick; Kasper, Stefan; Paul, Andreas; Wedemeyer, Heiner H.; Schmid, Kurt Werner; Schumacher, B.; Markus, P.; Siffert, Winfried; Schuler, Martin; Bachmann, Hagen Sjard; Virchow, I.;
    The prognostic impact of UDP-glucuronyltransferase 1A1*1 (UGT1A1*1) polymorphism in patients with advanced colorectal and non-colorectal cancer treated with irinotecan-based systemic chemotherapies
    Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie ; 28. September - 2. Oktober 2018, Wien,
    In: Oncology Research and Treatment Jg. 41 (2018) Nr. Suppl. 4, S. 122 - 123
    Online Volltext: dx.doi.org/ (Open Access)
  • Stelmach, Patrick; Manthey, I.; Siffert, Winfried; Bachmann, Hagen Sjard;
    Characterization of the promoter region of a variant of the beta-subunit of the human farnesyltransferase
    Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie e.V., 81th Annual Meeting, March 10 - 12, 2015, Kiel, Germany,
    In: Naunyn-Schmiedeberg's Archives of Pharmacology Jg. 388 (2015) Nr. Suppl. 1, S. 54
    Online Volltext: dx.doi.org/
  • Virchow, Isabel; Schmid, Kurt Werner; Rübben, Herbert; Heukomp, L. C.; Siffert, Winfried; Bachmann, Hagen Sjard;
    FNTB promoter polymorphisms influence survival in prostate cancer
    Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie, 9.-13. Oktober 2015, Basel, Schweiz,
    In: Oncology Research and Treatment Jg. 38 (2015) Nr. Suppl. 5, S. 80
    Online Volltext: dx.doi.org/
  • Wieneke, Heinrich; Siffert, Winfried; Svendsen, J. H.; Spencker, S.; Strohmer, B.; Le Marec, H.; Toivonen, L.; Martinez, J. G.; Huertas-Vazquez, A.; Chugh, S.
    Polymorphism in the GNAS gene predicts ventricular tachyarrhythmias and sudden cardiac death : results from the DISCOVERY trial and Oregon Sudden Death Study
    In: European Heart Journal Jg. 36 (2015) Nr. Suppl. 1: Basic and Translational Science Hot Line, S. 1209
    Online Volltext: dx.doi.org/
  • Bachmann, Hagen Sjard; Meier, W.; du Bois, A.; Kimmig, Rainer; Kuhlmann, J. D.; Siffert, Winfried; Sehouli, J.; Wollschlaeger, K.; Huober, J.; Hillemanns, P.; Burges, A.; Schmalfeldt, B.; Aminossadati, B.; Wimberger, Pauline;
    The FNTB-609G > C polymorphism as a possible predictive factor for efficacy of lonafarnib-treatment? : Exploratory analysis of a randomized phase II clinical trial in stage IIb-IV ovarian cancer, treated with first-line platinum-based chemotherapy with or without lonafarnib
    Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie e.V., 81th Annual Meeting, March 10 - 12, 2015, Kiel, Germany,
    In: Naunyn-Schmiedeberg's Archives of Pharmacology Jg. 388 (2015) Nr. Suppl. 1, S. 52
    Online Volltext: dx.doi.org/
  • Heubner, Martin; Kimmig, Rainer; Siffert, Winfried; Ulrich, F.
    The haplotype of three polymorphisms in the SATB1 promoter-region and impact on survival in breast cancer patients
    In: Journal of Clinical Oncology (JCO) Jg. 31 (2013) Nr. 15 Suppl., S. 584
  • Bachmann, Hagen Sjard; Liebig; Bonnet, Udo; Specka, M.; Augener, S.; Scherbaum, Norbert; Siffert, Winfried;
    The T-allele of the GNB3 825C > T polymorphism is associated with increased intensity of opiate withdrawal
    8th International Sphingolipid Club Meeting, Glasgow, UK, June 30 – July 2, 2010,
    In: Naunyn-Schmiedeberg's Archives of Pharmacology Jg. 381 (2010) Nr. Suppl. 1, S. 87
    Online Volltext: dx.doi.org/
  • Klenke, Stefanie; Frey, Ulrich; Nürnberger, Jens; Erbel, Raimund; Siffert, Winfried; Naber, Christoph;
    The functional GNAQ promoter polymorphism TT(-695/-694) GC is associated with increased cardiac output in healthy subjects and patients with coronary artery disease
    51th Annual Meeting Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie Mainz, March 23 – 25, 2010,
    In: Naunyn-Schmiedeberg's Archives of Pharmacology Jg. 381 (2010) Nr. Suppl. 1, S. 87
    Online Volltext: dx.doi.org/

    • Poster / Posterbeiträge

  • Friebus-Kardash, Justa; Möhlendick, Birte; Heinemann, Falko M.; Nela, E.; Kribben, Andreas; Siffert, Winfried; Eisenberger, Ute
    Differential Effects of CYP3A4*22 and POR*28 on Tacrolimus Metabolism and Alloimmunization after Kidney Tranplantation in Contrast to CYP3A5 Genotype
    In: Transplant International Jg. 34 (2021) Nr. S2, S. 33
    Online Volltext: dx.doi.org/ (Open Access)