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Aktuelle Veranstaltungen
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2024 WS
- Molekulare Mechanismen bakterieller Infektionen (*)
- Prinzipien der zellulären Signaltransduktion (*)
- Seminar für Molekularbiologie / Zellbiologie u. experimentelle Krebsforschung (mit Gastsprechern) (*)
- Anleitung zu selbständigem wissenschaftlichen Arbeiten (*)
- Molekulare Immunologie (*)
- Seminar für Studierende im Praktischen Jahr
Vergangene Veranstaltungen (max. 10)
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2024 SS
- Anleitung zu selbständigem wissenschaftlichen Arbeiten (*)
- Prinzipien der zellulären Signaltransduktion (*)
- Molekulare Mechanismen bakterieller Infektionen (*)
- Seminar für Molekularbiologie / Zellbiologie u. experimentelle Krebsforschung (mit Gastsprechern) (*)
- Seminar für Studierende im Praktischen Jahr
- Molekulare Immunologie (*)
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2023 WS
Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
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(Non)-Exertional Variables of Cardiopulmonary Exercise Testing in Heart Failure with and Without Cardiac AmyloidosisIn: Current Heart Failure Reports Jg. 21 (2024) Nr. 3, S. 224 - 237Online Volltext: dx.doi.org/ (Open Access)
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Current Therapies and Future Horizons in Cardiac Amyloidosis TreatmentIn: Current Heart Failure Reports Jg. 21 (2024) Nr. 4, S. 305 - 321Online Volltext: dx.doi.org/ (Open Access)
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Daratumumab in first-line treatment of patients with light chain amyloidosis and Mayo stage IIIb improves treatment response and overall survivalIn: Haematologica / The Hematology Journal Jg. 109 (2024) Nr. 1, S. 220 - 230Online Volltext: dx.doi.org/ (Open Access)
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Real-world analysis of teclistamab in 123 RRMM patients from GermanyIn: Leukemia Jg. 38 (2024) Nr. 2, S. 365 - 371Online Volltext: dx.doi.org/ (Open Access)
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Screening for Occult Transthyretin Amyloidosis in Patients with Severe Aortic Stenosis and Amyloid Red FlagsIn: Journal of Clinical Medicine (JCM) Jg. 13 (2024) Nr. 3, 671Online Volltext: dx.doi.org/ (Open Access)
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Teclistamab in relapsed or refractory AL amyloidosis : a multinational retrospective case seriesIn: Blood Jg. 143 (2024) Nr. 8, S. 734 - 737Online Volltext: dx.doi.org/
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Acid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinomaIn: Journal of Molecular Medicine Jg. 101 (2023) Nr. 7, S. 891 - 903Online Volltext: dx.doi.org/ (Open Access)
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Corneal confocal microscopy identifies corneal nerve loss and increased Langerhans cells in presymptomatic carriers and patients with hereditary transthyretin amyloidosisIn: Journal of Neurology Jg. 270 (2023) Nr. 7, S. 3483 - 3491Online Volltext: dx.doi.org/ (Open Access)
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Medications Modulating the Acid Sphingomyelinase/Ceramide System and 28-Day Mortality among Patients with SARS-CoV-2: An Observational StudyIn: Pharmaceuticals Jg. 16 (2023) Nr. 8, 1107Online Volltext: dx.doi.org/ (Open Access)
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Quantitative ⁹⁹mTc-DPD-SPECT/CT assessment of cardiac amyloidosisIn: Journal of Nuclear Cardiology Jg. 30 (2023) Nr. 1, S. 101 - 111Online Volltext: dx.doi.org/ (Open Access)
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Regression of Myocardial ⁹⁹mTc-DPD Uptake After Tafamidis Treatment of Cardiac Transthyretin AmyloidosisIn: Journal of Nuclear Medicine (JNM) Jg. 64 (2023) Nr. 7, S. 1083 - 1086Online Volltext: dx.doi.org/ (Open Access)
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Risk of Death in Individuals Hospitalized for COVID-19 With and Without Psychiatric Disorders : An Observational Multicenter Study in FranceIn: Biological Psychiatry Global Open Science Jg. 3 (2023) Nr. 1, S. 56 - 67Online Volltext: dx.doi.org/ (Open Access)
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Simultaneous targeting of mitochondrial Kv1.3 and lysosomal acid sphingomyelinase amplifies killing of pancreatic ductal adenocarcinoma cells in vitro and in vivoIn: Journal of Molecular Medicine Jg. 101 (2023) Nr. 3, S. 295 - 310Online Volltext: dx.doi.org/ (Open Access)
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A novel TTR mutation (p.Ala65Val) underlying late-onset hereditary transthyretin (ATTRv) amyloidosis with mixed cardiac and neuropathic phenotype : a case reportIn: BMC Neurology Jg. 22 (2022) Nr. 1, 469Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Acquired Hemophilia A : A Permanent Challenge for All PhysiciansIn: Medicines Jg. 9 (2022) Nr. 3, 21Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Antidepressant Use and Its Association with 28-Day Mortality in Inpatients with SARS-CoV-2 : Support for the FIASMA Model against COVID-19In: Journal of Clinical Medicine (JCM) Jg. 11 (2022) Nr. 19, 5882Online Volltext: dx.doi.org/ (Open Access)
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Antiviral and Anti-Inflammatory Activities of Fluoxetine in a SARS-CoV-2 Infection Mouse ModelIn: International Journal of Molecular Sciences (IJMS) Jg. 23 (2022) Nr. 21, S. 13623Online Volltext: dx.doi.org/ (Open Access)
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Association between FIASMA psychotropic medications and reduced risk of intubation or death in individuals with psychiatric disorders hospitalized for severe COVID-19 : an observational multicenter studyIn: Translational Psychiatry Jg. 12 (2022) 90Online Volltext: dx.doi.org/ (Open Access)
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Ceramide levels in blood plasma correlate with major depressive disorder severity and its neutralization abrogates depressive behavior in miceIn: The Journal of Biological Chemistry (JBC) Jg. 298 (2022) Nr. 8, 102185Online Volltext: dx.doi.org/ (Open Access)
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Clinical features and predictors of atrial fibrillation in patients with light-chain or transthyretin cardiac amyloidosisIn: ESC Heart Failure Jg. 9 (2022) Nr. 3, S. 1740 - 1748Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Comorbid medical conditions are a key factor to understand the relationship between psychiatric disorders and COVID-19-related mortality : Results from 49,089 COVID-19 inpatientsIn: Molecular Psychiatry Jg. 27 (2022) Nr. 3, S. 1278 - 1280Online Volltext: dx.doi.org/ (Open Access)
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Corneal confocal microscopy to detect early immune-mediated small nerve fibre loss in AL amyloidosisIn: Annals of Clinical and Translational Neurology Jg. 9 (2022) Nr. 6, S. 853 - 863Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Luspatercept, a two‐edged sword in beta‐thalassemia‐associated paravertebral extramedullary hematopoietic masses (EHMs)In: European Journal of Haematology Jg. 109 (2022) Nr. 6, S. 664 - 671Online Volltext: dx.doi.org/ (Open Access)
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Mitochondrial Kv1.3 Channels as Target for Treatment of Multiple MyelomaIn: Cancers Jg. 14 (2022) Nr. 8, 1955Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Prevalence and predictors of neurological manifestations in systemic AL amyloidosisIn: Journal of the Neurological Sciences Jg. 440 (2022) 120341Online Volltext: dx.doi.org/
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Sphingosine as a new antifungal agent against Candida and Aspergillus spp.In: International Journal of Molecular Sciences (IJMS) Jg. 23 (2022) Nr. 24, 15510Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasmaIn: Journal of Molecular Medicine Jg. 100 (2022) Nr. 10, S. 1493 - 1508Online Volltext: dx.doi.org/ (Open Access)
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¹⁸F-flutemetamol positron emission tomography in cardiac amyloidosisIn: Journal of Nuclear Cardiology Jg. 29 (2022) Nr. 2, S. 779 - 789Online Volltext: dx.doi.org/ (Open Access)
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Association Between FIASMAs and Reduced Risk of Intubation or Death in Individuals Hospitalized for Severe COVID-19: An Observational Multicenter StudyIn: Clinical Pharmacology & Therapeutics Jg. 110 (2021) Nr. 6, S. 1498 - 1511Online Volltext: dx.doi.org/ (Open Access)
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Daratumumab, lenalidomide, and dexamethasone in systemic light-chain amyloidosis: High efficacy, relevant toxicity and main adverse effect of gain 1q21In: American Journal of Hematology Jg. 96 (2021) Nr. 7, S. E253 - E257Online Volltext: dx.doi.org/ (Open Access)
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Ex vivo assay to evaluate the efficacy of drugs targeting sphingolipids in preventing SARS-CoV-2 infection of nasal epithelial cellsIn: STAR Protocols Jg. 2 (2021) Nr. 1, S. 100356Online Volltext: dx.doi.org/ (Open Access)
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Impact of time to diagnosis on Mayo stages, treatment outcome, and survival in patients with AL amyloidosis and cardiac involvementIn: European Journal of Haematology Jg. 107 (2021) Nr. 4, S. 449 - 457Online Volltext: dx.doi.org/ (Open Access)
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Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cellsIn: The Journal of Biological Chemistry (JBC) Jg. 296 (2021) 100701Online Volltext: dx.doi.org/ (Open Access)
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Integrative genomic analyses of patient-matched intracranial and extracranial metastases reveal a novel brain-specific landscape of genetic variants in driver genes of malignant melanomaIn: Cancers Jg. 13 (2021) Nr. 4, S. 731Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Pregnancies and neonatal outcomes in patients with sickle cell disease (SCD) : Still a (high-)risk constellation?In: Journal of Personalized Medicine Jg. 11 (2021) Nr. 9, 870Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Rare variant (p.Ser43Asn) of familial transthyretin amyloidosis associated with isolated cardiac phenotype : A case series with literature reviewIn: Molecular Genetics & Genomic Medicine Jg. 9 (2021) Nr. 12, e1581Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Repurposing antidepressants inhibiting the sphingomyelinase acid/ceramide system against COVID-19 : Current evidence and potential mechanismsIn: Molecular Psychiatry Jg. 26 (2021) Nr. 12, S. 7098 - 7099Online Volltext: dx.doi.org/ (Open Access)
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A Novel Visible Range FRET Probe for Monitoring Acid Sphingomyelinase Activity in Living CellsIn: Chemistry - A European Journal Jg. 26 (2020) Nr. 26, S. 5780 - 5783Online Volltext: dx.doi.org/ (Open Access)
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Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitroIn: Journal of Lipid Research Jg. 61 (2020) Nr. 6, S. 896 - 910Online Volltext: dx.doi.org/ (Open Access)
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Daratumumab for systemic AL amyloidosis : prognostic factors and adverse outcome with nephrotic-range albuminuriaIn: Blood Jg. 135 (2020) Nr. 18, S. 1517 - 1530Online Volltext: dx.doi.org/ (Open Access)
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Diagnosing cardiac amyloidosis in every-day practice : A practical guide for the cardiologistIn: International Journal of Cardiology (IJC) Heart & Vasculature Jg. 28 (2020) S. 100519Online Volltext: dx.doi.org/ (Open Access)
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Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial CellsIn: Cell Reports Medicine Jg. 1 (2020) Nr. 8, S. 100142Online Volltext: dx.doi.org/ (Open Access)
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Publisher Correction to: 18F-florbetaben positron emission tomography detects cardiac involvement in systemic AA amyloidosisIn: European Journal of Nuclear Medicine and Molecular Imaging Jg. 47 (2020) Nr. 13, S. 3196Online Volltext: dx.doi.org/ (Open Access)
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Sphingosine prevents binding of SARS-CoV-2 spike to its cellular receptor ACE2In: The Journal of Biological Chemistry (JBC) Jg. 295 (2020) Nr. 45, S. 15174 - 15182Online Volltext: dx.doi.org/ (Open Access)
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Veno-Venous Extracorporeal Membrane Oxygenation in Adult Patients with Sickle Cell Disease and Acute Chest Syndrome : a Single-Center ExperienceIn: Hemoglobin Jg. 44 (2020) Nr. 2, S. 71 - 77Online Volltext: dx.doi.org/
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¹⁸F-florbetaben positron computed tomography detects cardiac involvement in systemic AA amyloidosisIn: European Journal of Nuclear Medicine and Molecular Imaging Jg. 47 (2020) Nr. 13, S. 3186 - 3187Online Volltext: dx.doi.org/ (Open Access)
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Acid sphingomyelinase deficiency ameliorates farber diseaseIn: International Journal of Molecular Sciences (IJMS) Jg. 20 (2019) Nr. 24, S. 6253Online Volltext: dx.doi.org/ (Open Access)
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Clinical development of sphingosine as anti-bacterial drug : Inhalation of sphingosine in mini pigs has no adverse side effectsIn: Cellular Physiology and Biochemistry Jg. 53 (2019) Nr. 6, S. 1015 - 1028Online Volltext: dx.doi.org/ (Open Access)
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Inhibition of PI-3-K and AKT Amplifies Kv1.3 Inhibitor-Induced Death of Human T Leukemia CellsIn: Cellular Physiology and Biochemistry Jg. 53 (2019) Nr. S1, S. 1 - 10Online Volltext: dx.doi.org/ (Open Access)
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Signalling Effects Induced by Acid Ceramidase in Human Epithelial Or Leukemic Cell LinesIn: Cellular Physiology and Biochemistry Jg. 52 (2019) Nr. 5, S. 1092 - 1102Online Volltext: dx.doi.org/ (Open Access)
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Highlight : Sphingolipids in infectious biology and immunologyIn: Biological Chemistry Jg. 399 (2018) Nr. 10, S. 1113 - 1113Online Volltext: dx.doi.org/
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Pathological manifestations of Farber disease in a new mouse modelIn: Biological Chemistry Jg. 399 (2018) Nr. 10, S. 1183 - 1202Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Acid sphingomyelinase deficiency in Western diet-fed mice protects against adipocyte hypertrophy and diet-induced liver steatosisIn: Molecular Metabolism Jg. 6 (2017) Nr. 5, S. 416 - 427Online Volltext: dx.doi.org/ (Open Access)
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Melanoma cell metastasis via P-selectin-mediated activation of acid sphingomyelinase in plateletsIn: Clinical and Experimental Metastasis Jg. 34 (2017) Nr. 1, S. 25 - 35Online Volltext: dx.doi.org/
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Regulation of Arthritis Severity by the Acid SphingomyelinaseIn: Cellular Physiology and Biochemistry Jg. 43 (2017) Nr. 4, S. 1460 - 1471Online Volltext: dx.doi.org/ (Open Access)
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High Frequencies of Anti-Host Reactive CD8+ T Cells Ignore Non-Hematopoietic Antigen after Bone Marrow Transplantation in a Murine ModelIn: Cellular Physiology and Biochemistry Jg. 38 (2016) Nr. 4, S. 1343 - 1353Online Volltext: dx.doi.org/ (Open Access)
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Role of Acid Sphingomyelinase-Induced Signaling in Melanoma Cells for Hematogenous Tumor MetastasisIn: Cellular Physiology and Biochemistry Jg. 38 (2016) Nr. 1, S. 1 - 14Online Volltext: dx.doi.org/ (Open Access)
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Pseudomonas aeruginosa Pyocyanin Induces Neutrophil Death via Mitochondrial Reactive Oxygen Species and Mitochondrial Acid SphingomyelinaseIn: Antioxidants and Redox Signaling Jg. 22 (2015) Nr. 13, S. 1097 - 1110Online Volltext: dx.doi.org/ (Open Access)
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Regulation of hematogenous tumor metastasis by acid sphingomyelinaseIn: EMBO Molecular Medicine Jg. 7 (2015) Nr. 6, S. 714 - 734Online Volltext: dx.doi.org/ (Open Access)
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Targeting a mitochondrial potassium channel to fight cancerIn: Cell Calcium Jg. 58 (2015) Nr. 1, S. 131 - 138Online Volltext: dx.doi.org/
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Regulation of the inflammasome by ceramide in cystic fibrosis lungsIn: Cellular Physiology and Biochemistry Jg. 34 (2014) Nr. 1, S. 45 - 55Online Volltext: dx.doi.org/ (Open Access)
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Connexin 31 (GJB3) deficiency in mouse trophoblast stem cells alters giant cell differentiation and leads to loss of oxygen sensingIn: Biology of Reproduction Jg. 87 (2012) Nr. 2, S. 37Online Volltext: dx.doi.org/
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p53 protein expression in chronic lymphocytic leukemiaIn: Leukemia and Lymphoma Jg. 53 (2012) Nr. 7, S. 1282 - 1288Online Volltext: dx.doi.org/
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Kinase suppressor of Ras-1 protects against pulmonary Pseudomonas aeruginosa infectionsIn: Nature Medicine Jg. 17 (2011) Nr. 3, S. 341 - 346Online Volltext: dx.doi.org/
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Gene dosage effects in chronic lymphocytic leukemiaIn: Cancer Genetics and Cytogenetics Jg. 203 (2010) Nr. 2, S. 149 - 160Online Volltext: dx.doi.org/
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The zinc finger protein and transcriptional repressor Gfi1 as a regulator of the innate immune responseIn: Immunobiology Jg. 213 (2008) Nr. 3-4, S. 341 - 352Online Volltext: dx.doi.org/
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Ceramide : physiological and pathophysiological aspectsIn: Archives of Biochemistry and Biophysics (ABB) Jg. 462 (2007) Nr. 2, S. 171 - 175Online Volltext: dx.doi.org/
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Gründung einer Arbeitsgruppe „Lymphknotenmetastasierung“ am Westdeutschen Tumorzentrum (WTZE), Universitätsklinikum EssenIn: Der Urologe Jg. 46 (2007) Nr. 9, S. 1257 - 1260Online Volltext: dx.doi.org/
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Proapoptotische Antikörper als neue TumortherapeutikaIn: Der Urologe Jg. 46 (2007) Nr. 9, S. 1262 - 1265Online Volltext: dx.doi.org/
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Antidepressant Use and Its Association with 28-Day Mortality in Inpatients with SARS-CoV-2 : Support for the FIASMA Model against COVID-19
31st European Congress of Psychiatry, EPA 2023, 25-28 March 2023, Paris, France,In: European Psychiatry Jg. 66 (2023) Nr. S1, S. S118 - S119Online Volltext: dx.doi.org/ (Open Access) -
Real-World Analysis of Teclistamab in 115 RRMM Patients from GermanyIn: Blood Jg. 142 (2023) Nr. Supplement 1: Annual Meeting Abstracts (65th ASH Annual Meeting and Exposition, 9-12 Dezember 2023, San Diego), S. 3329 - 3329Online Volltext: dx.doi.org/ (Open Access)
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Screening for occult transthyretin amyloidosis in patients with degenerative aortic stenosis and amyloid red-flagsIn: European Journal of Heart Failure Jg. 25 (2023) Nr. Suppl. 2, S. 359 - 359
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Glomerular Fitration Rate and Lactate Dehydrogenase Predicts Survival in Mayo Iiib Stage Light-Chain AmyloidosisIn: Blood Jg. 140 (2022) Nr. Supplement 1: 64th Annual Meeting, S. 12571 - 12572Online Volltext: dx.doi.org/ (Open Access)
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Think twice : Anemia of chronic disease (ACD) due to angiomatoid fibrous histiocytoma (AFH)
Virtuelle Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie, 09.–11. Oktober 2020,In: Oncology Research and Treatment Jg. 43 (2020) Nr. Suppl. 4, S. 181Online Volltext: dx.doi.org/ (Open Access) -
Effects of nitric oxide on hematogenous metastasis
9th International Luebeck Conference Pathophysiology and Pharmacology of Erythropoietin and other Hemopoietic Grow Factors, 13 - 15 July 2012, Lübeck, Germany,In: American Journal of Hematology Jg. 87 (2012) Nr. 10, S. E112 - E112Online Volltext: dx.doi.org/ -
Role of the acid sphingomyelinase in hematogenous tumor metastasis in a mouse model
Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Onkologie. Basel, 30.09.–04.10. 2011,In: Onkologie Jg. 34 (2011) Nr. Suppl. 6, S. 46Online Volltext: dx.doi.org/ -
Role of the antigenic stimulation in the pathogenesis of chronic lymphocytic leukemia
Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Onkologie. Berlin, 1.–5. Oktober 2010,In: Onkologie Jg. 33 (2010) Nr. Suppl. 6, S. 39Online Volltext: dx.doi.org/ -
Analysis of lipids in ceramide-enriched membrane domainsIn: Lipid Rafts: Methods and Protocols / Bieberich, Erhard (Hrsg.) 2021, S. 207 - 213Online Volltext: dx.doi.org/
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Hemmung der sauren Sphingomyelinase als neuer therapeutischer AngriffspunktDuisburg ; Essen (2020) 1 CD-ROM