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Hufelandstr. 55
45122 Essen
45122 Essen
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Gruppe der akademischen Mitarbeiterinnen und Mitarbeiter, Institut für Molekularbiologie (Tumorforschung)
Aktuelle Veranstaltungen
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2024 WS
Vergangene Veranstaltungen (max. 10)
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2024 SS
- Praktikum Zell- und Molekularbiologie für med. Biologen (Bachelor) (PV)
- Prinzipien der zellulären Signaltransduktion (*)
- Seminar für Molekularbiologie / Zellbiologie u. experimentelle Krebsforschung (mit Gastsprechern) (*)
- Anleitung zu selbständigem wissenschaftlichen Arbeiten (*)
- Molekulare Immunologie (*)
- Molekulare Mechanismen bakterieller Infektionen (*)
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2023 WS
Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
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Fluoxetine and Sertraline Potently Neutralize the Replication of Distinct SARS-CoV-2 VariantsIn: Viruses Jg. 16 (2024) Nr. 4, 545Online Volltext: dx.doi.org/ (Open Access)
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Acid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinomaIn: Journal of Molecular Medicine Jg. 101 (2023) Nr. 7, S. 891 - 903Online Volltext: dx.doi.org/ (Open Access)
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Medications Modulating the Acid Sphingomyelinase/Ceramide System and 28-Day Mortality among Patients with SARS-CoV-2: An Observational StudyIn: Pharmaceuticals Jg. 16 (2023) Nr. 8, 1107Online Volltext: dx.doi.org/ (Open Access)
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Risk of Death in Individuals Hospitalized for COVID-19 With and Without Psychiatric Disorders : An Observational Multicenter Study in FranceIn: Biological Psychiatry Global Open Science Jg. 3 (2023) Nr. 1, S. 56 - 67Online Volltext: dx.doi.org/ (Open Access)
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Simultaneous targeting of mitochondrial Kv1.3 and lysosomal acid sphingomyelinase amplifies killing of pancreatic ductal adenocarcinoma cells in vitro and in vivoIn: Journal of Molecular Medicine Jg. 101 (2023) Nr. 3, S. 295 - 310Online Volltext: dx.doi.org/ (Open Access)
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Antidepressant Use and Its Association with 28-Day Mortality in Inpatients with SARS-CoV-2 : Support for the FIASMA Model against COVID-19In: Journal of Clinical Medicine (JCM) Jg. 11 (2022) Nr. 19, 5882Online Volltext: dx.doi.org/ (Open Access)
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Antimicrobial effects of inhaled sphingosine against Pseudomonas aeruginosa in isolated ventilated and perfused pig lungsIn: PLoS ONE Jg. 17 (2022) e0271620Online Volltext: dx.doi.org/ (Open Access)
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Cell-intrinsic ceramides determine T cell function during melanoma progressionIn: eLife Jg. 11 (2022) e83073Online Volltext: dx.doi.org/ (Open Access)
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Comorbid medical conditions are a key factor to understand the relationship between psychiatric disorders and COVID-19-related mortality : Results from 49,089 COVID-19 inpatientsIn: Molecular Psychiatry Jg. 27 (2022) Nr. 3, S. 1278 - 1280Online Volltext: dx.doi.org/ (Open Access)
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Acid ceramidase rescues cystic fibrosis mice from pulmonary infectionsIn: Infection and Immunity Jg. 89 (2021) Nr. 2, S. e00677 - 20Online Volltext: dx.doi.org/ (Open Access)
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Ceramide and related molecules in viral infectionsIn: International Journal of Molecular Sciences (IJMS) Jg. 22 (2021) Nr. 11,Online Volltext: dx.doi.org/ (Open Access)
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Corrigendum to: “Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the family”In: Redox Biology Jg. 45 (2021) 102036Online Volltext: dx.doi.org/ (Open Access)
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Ex vivo assay to evaluate the efficacy of drugs targeting sphingolipids in preventing SARS-CoV-2 infection of nasal epithelial cellsIn: STAR Protocols Jg. 2 (2021) Nr. 1, S. 100356Online Volltext: dx.doi.org/ (Open Access)
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Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cellsIn: The Journal of Biological Chemistry (JBC) Jg. 296 (2021) 100701Online Volltext: dx.doi.org/ (Open Access)
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Integrative genomic analyses of patient-matched intracranial and extracranial metastases reveal a novel brain-specific landscape of genetic variants in driver genes of malignant melanomaIn: Cancers Jg. 13 (2021) Nr. 4, S. 731Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Interferon regulatory factor 8 regulates expression of acid ceramidase and infection susceptibility in cystic fibrosisIn: The Journal of Biological Chemistry (JBC) Jg. 296 (2021) 100650Online Volltext: dx.doi.org/ (Open Access)
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Repurposing antidepressants inhibiting the sphingomyelinase acid/ceramide system against COVID-19 : Current evidence and potential mechanismsIn: Molecular Psychiatry Jg. 26 (2021) Nr. 12, S. 7098 - 7099Online Volltext: dx.doi.org/ (Open Access)
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Staphylococcus aureus α-Toxin Induces Acid Sphingomyelinase Release From a Human Endothelial Cell LineIn: Frontiers in Microbiology Jg. 12 (2021) 694489Online Volltext: dx.doi.org/ (Open Access)
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Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe diseaseIn: Nature Communications Jg. 11 (2020) Nr. 1, S. 1338Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Acid sphingomyelinase regulates TH2 cytokine release and bronchial asthmaIn: Allergy Jg. 75 (2020) Nr. 3, S. 603 - 615Online Volltext: dx.doi.org/ (Open Access)
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Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitroIn: Journal of Lipid Research Jg. 61 (2020) Nr. 6, S. 896 - 910Online Volltext: dx.doi.org/ (Open Access)
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Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the familyIn: Redox Biology Jg. 37 (2020) 101705Online Volltext: dx.doi.org/ (Open Access)
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Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial CellsIn: Cell Reports Medicine Jg. 1 (2020) Nr. 8, S. 100142Online Volltext: dx.doi.org/ (Open Access)
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Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic FibrosisIn: American Journal of Respiratory and Critical Care Medicine (AJRCCM) Jg. 202 (2020) Nr. 8, S. 1133 - 1145Online Volltext: dx.doi.org/ (Open Access)
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Role of 1-Deoxysphingolipids in docetaxel neurotoxicityIn: Journal of Neurochemistry Jg. 154 (2020) Nr. 6,Online Volltext: dx.doi.org/ (Open Access)
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Sphingosine is able to prevent and eliminate Staphylococcus epidermidis biofilm formation on different orthopedic implant materials in vitroIn: Journal of Molecular Medicine Jg. 98 (2020) Nr. 2, S. 209 - 219Online Volltext: dx.doi.org/ (Open Access)
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Sphingosine kills bacteria by binding to cardiolipinIn: The Journal of Biological Chemistry (JBC) Jg. 295 (2020) Nr. 22, S. 7686 - 7696Online Volltext: dx.doi.org/ (Open Access)
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Sphingosine prevents binding of SARS-CoV-2 spike to its cellular receptor ACE2In: The Journal of Biological Chemistry (JBC) Jg. 295 (2020) Nr. 45, S. 15174 - 15182Online Volltext: dx.doi.org/ (Open Access)
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Acid sphingomyelinase deficiency ameliorates farber diseaseIn: International Journal of Molecular Sciences (IJMS) Jg. 20 (2019) Nr. 24, S. 6253Online Volltext: dx.doi.org/ (Open Access)
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Clinical development of sphingosine as anti-bacterial drug : Inhalation of sphingosine in mini pigs has no adverse side effectsIn: Cellular Physiology and Biochemistry Jg. 53 (2019) Nr. 6, S. 1015 - 1028Online Volltext: dx.doi.org/ (Open Access)
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Inhibition of PI-3-K and AKT Amplifies Kv1.3 Inhibitor-Induced Death of Human T Leukemia CellsIn: Cellular Physiology and Biochemistry Jg. 53 (2019) Nr. S1, S. 1 - 10Online Volltext: dx.doi.org/ (Open Access)
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Intestinal acid sphingomyelinase protects from severe pathogen-driven colitisIn: Frontiers in Immunology Jg. 10 (2019) 1386Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Pharmacological Inhibition of Acid Sphingomyelinase Ameliorates Experimental Autoimmune EncephalomyelitisIn: Neurosignals Jg. 27 (2019) Nr. S1, S. 20 - 31Online Volltext: dx.doi.org/ (Open Access)
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Signalling Effects Induced by Acid Ceramidase in Human Epithelial Or Leukemic Cell LinesIn: Cellular Physiology and Biochemistry Jg. 52 (2019) Nr. 5, S. 1092 - 1102Online Volltext: dx.doi.org/ (Open Access)
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Specific inhibition of the NLRP3 inflammasome as an antiinflammatory strategy in cystic fibrosisIn: American Journal of Respiratory and Critical Care Medicine (AJRCCM) Jg. 200 (2019) Nr. 11, S. 1381 - 1391Online Volltext: dx.doi.org/
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Sphingosine-coating of plastic surfaces prevents ventilator-associated pneumoniaIn: Journal of Molecular Medicine Jg. 97 (2019) Nr. 8, S. 1195 - 1211Online Volltext: dx.doi.org/ (Open Access)
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T cell-specific overexpression of acid sphingomyelinase results in elevated T cell activation and reduced parasitemia during Plasmodium yoelii infectionIn: Frontiers in Immunology Jg. 10 (2019) S. 1225Online Volltext: dx.doi.org/ (Open Access)
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Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramideIn: Molecular Psychiatry Jg. 23 (2018) Nr. 12, S. 2324 - 2346Online Volltext: dx.doi.org/ (Open Access)
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Antidepressants regulate autophagy by targeting acid sphingomyelinaseIn: Molecular Psychiatry Jg. 23 (2018) Nr. 12, S. 2251Online Volltext: dx.doi.org/
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Blockade of experimental multiple sclerosis by inhibition of the acid sphingomyelinase/ceramide systemIn: Neurosignals Jg. 25 (2018) Nr. 1, S. 88 - 97Online Volltext: dx.doi.org/ (Open Access)
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Highlight : Sphingolipids in infectious biology and immunologyIn: Biological Chemistry Jg. 399 (2018) Nr. 10, S. 1113 - 1113Online Volltext: dx.doi.org/
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Pathological manifestations of Farber disease in a new mouse modelIn: Biological Chemistry Jg. 399 (2018) Nr. 10, S. 1183 - 1202Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Pulmonary infection of cystic fibrosis mice with Staphylococcus aureus requires expression of α-toxinIn: Biological Chemistry Jg. 399 (2018) Nr. 10, S. 1203 - 1213Online Volltext: dx.doi.org/
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Sphingolipids as targets for inhalation treatment of cystic fibrosisIn: Advanced Drug Delivery Reviews Jg. 133 (2018) S. 66 - 75Online Volltext: dx.doi.org/
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Staphylococcus aureus alpha-toxin disrupts endothelial-cell tight junctions via acid sphingomyelinase and ceramideIn: Infection and Immunity Jg. 86 (2018) Nr. 1, S. e00606 - 17Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Targeting the potassium channel Kv1.3 kills glioblastoma cellsIn: Neurosignals Jg. 25 (2018) Nr. 1, S. 26 - 38Online Volltext: dx.doi.org/ (Open Access)
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Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelinationIn: PLoS ONE Jg. 12 (2017) Nr. 6, S. e0178622Online Volltext: dx.doi.org/ (Open Access)
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Direct pharmacological targeting of a mitochondrial ion channel selectively kills tumor cells in vivoIn: Cancer Cell Jg. 31 (2017) Nr. 4, S. 516 - 531.e10Online Volltext: dx.doi.org/ (Open Access)
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Glucosylceramide Critically Contributes to the Host Defense of Cystic Fibrosis LungsIn: Cellular Physiology and Biochemistry Jg. 41 (2017) Nr. 3, S. 1208 - 1218Online Volltext: dx.doi.org/ (Open Access)
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Melanoma cell metastasis via P-selectin-mediated activation of acid sphingomyelinase in plateletsIn: Clinical and Experimental Metastasis Jg. 34 (2017) Nr. 1, S. 25 - 35Online Volltext: dx.doi.org/
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Neutrophils Kill Reactive Oxygen Species-Resistant Pseudomonas aeruginosa by SphingosineIn: Cellular Physiology and Biochemistry Jg. 43 (2017) Nr. 4, S. 1603 - 1616Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Regulation of Arthritis Severity by the Acid SphingomyelinaseIn: Cellular Physiology and Biochemistry Jg. 43 (2017) Nr. 4, S. 1460 - 1471Online Volltext: dx.doi.org/ (Open Access)
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Sphingosine's role in epithelial host defense : a natural antimicrobial and novel therapeuticIn: Biochimie Jg. 141 (2017) S. 91 - 96Online Volltext: dx.doi.org/
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Staphylococcus aureus α-Toxin Induces Inflammatory Cytokines via Lysosomal Acid Sphingomyelinase and CeramidesIn: Cellular Physiology and Biochemistry Jg. 43 (2017) Nr. 6, S. 2170 - 2184Online Volltext: dx.doi.org/ (Open Access)
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The activity of the neutral sphingomyelinase is important in T cell recruitment and directional migrationIn: Frontiers in Immunology Jg. 8 (2017) S. 1007Online Volltext: dx.doi.org/ (Open Access)
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β1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingosine, Promoting Bacterial InfectionsIn: Cell Host & Microbe Jg. 21 (2017) Nr. 6, S. 707 - 718.e8Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Inhibition of Acid Sphingomyelinase Allows for Selective Targeting of CD4+ Conventional versus Foxp3+ Regulatory T CellsIn: The Journal of Immunology (JI) Jg. 197 (2016) Nr. 8, S. 3130 - 3141Online Volltext: dx.doi.org/ (Open Access)
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Lack of Sphingosine Causes Susceptibility to Pulmonary Staphylococcus Aureus Infections in Cystic FibrosisIn: Cellular Physiology and Biochemistry Jg. 38 (2016) Nr. 6, S. 2094 - 2102Online Volltext: dx.doi.org/ (Open Access)
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Role of Acid Sphingomyelinase-Induced Signaling in Melanoma Cells for Hematogenous Tumor MetastasisIn: Cellular Physiology and Biochemistry Jg. 38 (2016) Nr. 1, S. 1 - 14Online Volltext: dx.doi.org/ (Open Access)
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A central role for the acid sphingomyelinase/ceramide system in neurogenesis and major depressionIn: Journal of Neurochemistry Jg. 134 (2015) Nr. 2, S. 183 - 192Online Volltext: dx.doi.org/
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Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in miceIn: Nature Biotechnology Jg. 33 (2015) Nr. 1, S. 81 - 88Online Volltext: dx.doi.org/
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Novel mechanisms of action of classical chemotherapeutic agents on sphingolipid pathwaysIn: Biological Chemistry Jg. 396 (2015) Nr. 6-7, S. 669 - 679Online Volltext: dx.doi.org/
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Pseudomonas aeruginosa Pyocyanin Induces Neutrophil Death via Mitochondrial Reactive Oxygen Species and Mitochondrial Acid SphingomyelinaseIn: Antioxidants and Redox Signaling Jg. 22 (2015) Nr. 13, S. 1097 - 1110Online Volltext: dx.doi.org/ (Open Access)
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Regulation of hematogenous tumor metastasis by acid sphingomyelinaseIn: EMBO Molecular Medicine Jg. 7 (2015) Nr. 6, S. 714 - 734Online Volltext: dx.doi.org/ (Open Access)
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Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogonsIn: Frontiers in Physiology (2014) Nr. 5, S. 331Online Volltext: dx.doi.org/ (Open Access)
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Invariant natural killer T (iNKT) cells prevent autoimmunity, but induce pulmonary inflammation in cystic fibrosisIn: Cellular Physiology and Biochemistry Jg. 34 (2014) Nr. 1, S. 56 - 70Online Volltext: dx.doi.org/ (Open Access)
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Regulation of the inflammasome by ceramide in cystic fibrosis lungsIn: Cellular Physiology and Biochemistry Jg. 34 (2014) Nr. 1, S. 45 - 55Online Volltext: dx.doi.org/ (Open Access)
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Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugsIn: Nature Medicine Jg. 19 (2013) Nr. 7, S. 934 - 938Online Volltext: dx.doi.org/
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Clofazimine, Psora-4 and PAP-1, inhibitors of the potassium channel Kv1.3, as a new and selective therapeutic strategy in chronic lymphocytic leukemiaIn: Leukemia Jg. 27 (2013) Nr. 8, S. 1782 - 1785Online Volltext: dx.doi.org/
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Glioma Cell Death Induced by Irradiation or Alkylating Agent Chemotherapy Is Independent of the Intrinsic Ceramide PathwayIn: PLoS ONE Jg. 8 (2013) Nr. 5, S. e63527Online Volltext: dx.doi.org/ (Open Access)
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Targeting the ceramide system in cancerIn: Cancer Letters Jg. 332 (2013) Nr. 2, S. 286 - 294Online Volltext: dx.doi.org/
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Wirkungsvolle Lipide : Sphingolipide, bakterielle Infektionen und zystische FibroseIn: Unikate: Berichte aus Forschung und Lehre (2013) Nr. 44: Medizin: 50 Jahre Universitätsklinikum Essen, S. 22 - 31Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Role of CD95 in pulmonary inflammation and infection in cystic fibrosisIn: Journal of Molecular Medicine Jg. 90 (2012) Nr. 9, S. 1011 - 1023Online Volltext: dx.doi.org/
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Lipids in cystic fibrosisIn: Expert Review of Respiratory Medicine Jg. 5 (2011) Nr. 4, S. 527 - 535Online Volltext: dx.doi.org/
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Molecular Analysis of Staphylococcus Aureus Isolates from an Ongoing Prospective Observational Longitudinal Multicenter Study Determining Staphylococcus Aureus Airway Colonization or Infection in Cystic Fibrosis PatientsIn: Pediatric pulmonology Jg. 34 (2011) S. 323 - 323Online Volltext: dx.doi.org/
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Accumulation of ceramide in the trachea and intestine of cystic fibrosis mice causes inflammation and cell deathIn: Biochemical and Biophysical Research Communications (BBRC) Jg. 403 (2010) Nr. 3-4, S. 368 - 374Online Volltext: dx.doi.org/
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Acid sphingomyelinase inhibitors normalize pulmonary ceramide and inflammation in cystic fibrosisIn: American Journal of Respiratory Cell and Molecular Biology Jg. 42 (2010) Nr. 6, S. 716 - 724Online Volltext: dx.doi.org/
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CFTR-dependent susceptibility of the cystic fibrosis-host to Pseudomonas aeruginosaIn: International Journal of Medical Microbiology (IJMM) Jg. 300 (2010) Nr. 8, S. 578 - 583Online Volltext: dx.doi.org/
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Ceramide in pseudomonas aeruginosa infections and cystic fibrosisIn: Cellular Physiology and Biochemistry Jg. 26 (2010) Nr. 1, S. 57 - 66Online Volltext: dx.doi.org/ (Open Access)
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Ceramide in redox signaling and cardiovascular diseasesIn: Cellular Physiology and Biochemistry Jg. 26 (2010) Nr. 1, S. 41 - 48Online Volltext: dx.doi.org/ (Open Access)
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The Role of Sphingolipids and Ceramide in Pulmonary Inflammation in Cystic FibrosisIn: Open Respiratory Medicine Journal Jg. 4 (2010) S. 39 - 47Online Volltext: dx.doi.org/
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Antidepressant Use and Its Association with 28-Day Mortality in Inpatients with SARS-CoV-2 : Support for the FIASMA Model against COVID-19
31st European Congress of Psychiatry, EPA 2023, 25-28 March 2023, Paris, France,In: European Psychiatry Jg. 66 (2023) Nr. S1, S. S118 - S119Online Volltext: dx.doi.org/ (Open Access) -
Development of sphingosine-coupled oxygen carriers as novel drugs for treating pneumonia
98th Meeting of the German Physiological Society, 30 September ‐ 2 October 2019, Ulm, Germany,In: Acta Physiologica Jg. 227 (2019) Nr. S719, B 04-10 -
Acid SphingomyelinaseIn: Sphingolipids: Basic Science and Drug Development / Gulbins, Erich; Petrache, Irena 2013, S. 77 - 88Online Volltext: dx.doi.org/
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Bacterial infections and ceramideIn: Sphingolipids in Disease / Gulbins, Erich; Petrache, Irina 2013, S. 305 - 320Online Volltext: dx.doi.org/
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Rolle vonSphingolipidenbei Entzündungen und InfektionenDuisburg ; Essen (2017) 1 CD-ROM