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Dr. rer. nat. Heike Grassmé

Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.

    Artikel in Zeitschriften

  • Wu, Yuqing; Riehle, Andrea; Pollmeier, Barbara; Kadow, Stephanie; Schumacher, Fabian; Drab, Marek; Kleuser, Burkhard; Gulbins, Erich; Grassmé, Heike
    Caveolin-1 affects early mycobacterial infection and apoptosis in macrophages and mice
    In: Tuberculosis Jg. 147 (2024) 102493
    Online Volltext: dx.doi.org/ (Open Access)
  • May, Helene; Liu, Yongjie; Kadow, Stephanie; Edwards, Michael J.; Keitsch, Simone; Wilker, Barbara; Kamler, Markus; Grassmé, Heike; Wu, Yuqing; Gulbins, Erich
    Sphingosine kills intracellular Pseudomonas aeruginosa and Staphylococcus aureus
    In: Pathogens and Disease Jg. 82 (2024) ftae016
    Online Volltext: dx.doi.org/ (Open Access)
  • Schnitker, Fabian; Liu, Yongjie; Keitsch, Simone; Soddemann, Matthias; Verhasselt, Hedda Luise; Kehrmann, Jan; Grassmé, Heike; Kamler, Markus; Gulbins, Erich; Wu, Yuqing
    Reduced Sphingosine in Cystic Fibrosis Increases Susceptibility to Mycobacterium abscessus Infections
    In: International Journal of Molecular Sciences (IJMS) Jg. 24 (2023) Nr. 18, 14004
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Wu, Yuqing; Liu, Yongjie; Gulbins, Erich; Grassmé, Heike
    The Anti-Infectious Role of Sphingosine in Microbial Diseases
    In: Cells Jg. 10 (2021) Nr. 5, 1105
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Wu, Yuqing; Li, Cao; Peng, Huiming; Swaidan, Ashraf; Riehle, Andrea; Pollmeier, Barbara; Zhang, Yang; Gulbins, Erich; Grassmé, Heike
    Acid Sphingomyelinase Contributes to the Control of Mycobacterial Infection via a Signaling Cascade Leading from Reactive Oxygen Species to Cathepsin D
    In: Cells Jg. 9 (2020) Nr. 11, S. 2406
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Li, Cao; Wang, Anni; Wu, Yuqing; Gulbins, Erich; Grassmé, Heike; Zhao, Zhigang
    Acid Sphingomyelinase-Ceramide System in Bacterial Infections
    In: Cellular Physiology and Biochemistry Jg. 52 (2019) Nr. 2, S. 280 - 301
    Online Volltext: dx.doi.org/ (Open Access)
  • Wu, Yuqing; Gulbins, Erich; Grassmé, Heike
    Crosstalk between sphingomyelinases and reactive oxygen species in mycobacterial infection
    In: Antioxidants and Redox Signaling Jg. 28 (2018) Nr. 10, S. 935 - 948
    Online Volltext: dx.doi.org/
  • Wu, Yuqing; Li, Cao; Riehle, Andrea; Pollmeier, Barbara; Gulbins, Erich; Grassmé, Heike
    Mycobacterial Infection is Promoted by Neutral Sphingomyelinase 2 Regulating a Signaling Cascade Leading to Activation of β1-Integrin
    In: Cellular Physiology and Biochemistry Jg. 51 (2018) Nr. 4, S. 1815 - 1829
    Online Volltext: dx.doi.org/ (Open Access)
  • Li, Cao; Wu, Yuqing; Riehle, Andrea; Orian-Rousseau, Véronique; Zhang, Yang; Gulbins, Erich; Grassmé, Heike
    Regulation of Staphylococcus aureus Infection of Macrophages by CD44, Reactive Oxygen Species, and Acid Sphingomyelinase
    In: Antioxidants and Redox Signaling Jg. 28 (2018) Nr. 10, S. 916 - 934
    Online Volltext: dx.doi.org/ (Open Access)
  • Becker-Flegler, Katrin; Riethmüller, Joachim; Seitz, Aaron P.; Gardner, Aaron; Boudreau, Ryan; Kamler, Markus; Kleuser, Burkhard; Schuchman, Edward; Caldwell, Charles C.; Edwards, Michael J.; Grassmé, Heike; Brodlie, Malcolm; Gulbins, Erich
    Sphingolipids as targets for inhalation treatment of cystic fibrosis
    In: Advanced Drug Delivery Reviews Jg. 133 (2018) S. 66 - 75
    Online Volltext: dx.doi.org/
  • Becker-Flegler, Katrin; Fahsel, Björn; Kemper, Hannes; Mayeres, Joelina; Li, Cao; Wilker, Barbara; Keitsch, Simone; Soddemann, Matthias; Sehl, Carolin; Kohnen, Marcus; Edwards, Michael J.; Grassmé, Heike; Caldwell, Charles C.; Seitz, Aaron; Fraunholz, Martin; Gulbins, Erich
    Staphylococcus aureus alpha-toxin disrupts endothelial-cell tight junctions via acid sphingomyelinase and ceramide
    In: Infection and Immunity Jg. 86 (2018) Nr. 1, S. e00606 - 17
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Wu, Yuqing; Gulbins, Erich; Grassmé, Heike
    The function of sphingomyelinases in mycobacterial infections
    In: Biological Chemistry Jg. 399 (2018) Nr. 10, S. 1125 - 1133
    Online Volltext: dx.doi.org/
  • Li, Cao; Wu, Yuqing; Riehle, Andrea; Ma, Jie; Kamler, Markus; Gulbins, Erich; Grassmé, Heike
    Staphylococcus aureus survives in cystic fibrosis macrophages, forming a reservoir for chronic pneumonia
    In: Infection and Immunity Jg. 85 (2017) Nr. 5, S. e00883-16-1 - e00883-16-11
    Online Volltext: dx.doi.org/ (Open Access)
  • Grassmé, Heike; Henry, Brian; Ziobro, Regan; Becker, Katrin Anne; Riethmüller, Joachim; Gardner, Aaron; Seitz, Aaron P.; Steinmann, Jörg; Lang, Stephan; Ward, Christopher; Schuchman, Edward H.; Caldwell, Charles C.; Kamler, Markus; Edwards, Michael J.; Brodlie, Malcolm; Gulbins, Erich
    β1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingosine, Promoting Bacterial Infections
    In: Cell Host & Microbe Jg. 21 (2017) Nr. 6, S. 707 - 718.e8
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Tavakoli Tabazavareh, Shaghayegh; Seitz, Aaron P.; Jernigan, Peter L.; Sehl, Carolin; Keitsch, Simone; Lang, Stephan; Kahl, Barbara C.; Edwards, Michael John Richard; Grassmé, Heike; Gulbins, Erich; Becker-Flegler, Katrin
    Lack of Sphingosine Causes Susceptibility to Pulmonary Staphylococcus Aureus Infections in Cystic Fibrosis
    In: Cellular Physiology and Biochemistry Jg. 38 (2016) Nr. 6, S. 2094 - 2102
    Online Volltext: dx.doi.org/ (Open Access)
  • Hoehn, Richard; Monse, Marlene; Pohl, Ella; Wranik, Sina; Wilker, Barbara; Keitsch, Simone; Soddemann, Matthias; Kornhuber, Johannes; Kohnen, Marcus; Edwards, Michael J; Grassmé, Heike; Gulbins, Erich
    Melatonin Acts as an Antidepressant by Inhibition of the Acid Sphingomyelinase/Ceramide System
    In: Neurosignals Jg. 24 (2016) Nr. 1, S. 48 - 58
    Online Volltext: dx.doi.org/ (Open Access)
  • Gulbins, Anne; Grassmé, Heike; Hoehn, Richard; Kohnen, Marcus; Edwards, Michael J; Kornhuber, Johannes; Gulbins, Erich
    Role of Janus-Kinases in Major Depressive Disorder
    In: Neurosignals Jg. 24 (2016) Nr. 1, S. 71 - 80
    Online Volltext: dx.doi.org/ (Open Access)
  • Peng, Huiming; Li, Cao; Kadow, Stephanie; Henry, Brian D.; Steinmann, Jörg; Becker, Katrin Anne; Riehle, Andrea; Beckmann, Natalie; Wilker, Barbara; Li, Pin-Lan; Pritts, Timothy; Edwards, Michael J.; Zhang, Yang; Gulbins, Erich; Grassmé, Heike
    Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis
    In: Journal of Molecular Medicine Jg. 93 (2015) Nr. 6, S. 675 - 689
    Online Volltext: dx.doi.org/ (Open Access)
  • Grassmé, Heike; Jernigan, Peter L; Hoehn, Richard S; Wilker, Barbara; Soddemann, Matthias; Edwards, Michael J; Müller, Christian P; Kornhuber, Johannes; Gulbins, Erich
    Inhibition of Acid Sphingomyelinase by Antidepressants Counteracts Stress-Induced Activation of P38-Kinase in Major Depression
    In: Neurosignals Jg. 23 (2015) Nr. 1, S. 84 - 92
    Online Volltext: dx.doi.org/ (Open Access)
  • Managò, Antonella; Becker-Flegler, Katrin; Carpinteiro, Alexander; Wilker, Barbara; Soddemann, Matthias; Seitz, Aaron P.; Edwards, Michael John Richard; Grassmé, Heike; Szabò, Ildikò M.; Gulbins, Erich
    Pseudomonas aeruginosa Pyocyanin Induces Neutrophil Death via Mitochondrial Reactive Oxygen Species and Mitochondrial Acid Sphingomyelinase
    In: Antioxidants and Redox Signaling Jg. 22 (2015) Nr. 13, S. 1097 - 1110
    Online Volltext: dx.doi.org/ (Open Access)
  • Carpinteiro, Alexander; Becker-Flegler, Katrin; Japtok, Lukasz; Hessler, Gabriele; Keitsch, Simone; Požgajovà, Miroslava; Schmid, Kurt Werner; Adams, Constantin; Müller, Stefan; Kleuser, Burkhard; Edwards, Michael J.; Grassmé, Heike; Helfrich, Iris; Gulbins, Erich
    Regulation of hematogenous tumor metastasis by acid sphingomyelinase
    In: EMBO Molecular Medicine Jg. 7 (2015) Nr. 6, S. 714 - 734
    Online Volltext: dx.doi.org/ (Open Access)
  • Jernigan, Peter L.; Hoehn, Richard S.; Grassmé, Heike; Edwards, Michael J.; Müller, Christian P.; Kornhuber, Johannes; Gulbins, Erich
    Sphingolipids in major depression
    In: Neurosignals Jg. 23 (2015) S. 49 - 58
    Online Volltext: dx.doi.org/ (Open Access)
  • Mueller, Nora; Avota, Elita; Collenburg, Lena; Grassmé, Heike; Schneider-Schaulies, Sibylle
    Neutral Sphingomyelinase in Physiological and Measles Virus Induced T Cell Suppression
    In: PLoS Pathogens Jg. 10 (2014) Nr. 12, S. e1004574
    Online Volltext: dx.doi.org/ (Open Access)
  • Grassmé, Heike; Carpinteiro, Alexander; Edwards, Michael J; Gulbins, Erich; Becker-Flegler, Katrin
    Regulation of the inflammasome by ceramide in cystic fibrosis lungs
    In: Cellular Physiology and Biochemistry Jg. 34 (2014) Nr. 1, S. 45 - 55
    Online Volltext: dx.doi.org/ (Open Access)
  • Pewzner-Jung, Yael; Tavakoli Tabazavareh, Shaghayegh; Grassmé, Heike; Becker, Katrin A.; Japtok, Lukasz; Steinmann, Jörg; Joseph, Tammar; Lang, Stephan; Tuemmler, Burkhard; Schuchman, Edward H.; Lentsch, Alex B.; Kleuser, Burkhard P.; Edwards, Michael J. R.; Futerman, Anthony H.; Gulbins, Erich
    Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa
    In: EMBO Molecular Medicine Jg. 6 (2014) Nr. 9, S. 1205 - 1214
    Online Volltext: dx.doi.org/ (Open Access)
  • Gulbins, Erich; Palmada, Monica; Reichel, Martin; Lüth, Anja; Böhmer, Christoph; Amato, Davide; Müller, Christian P.; Tischbirek, Carsten H.; Groemer, Teja W.; Tabatabai, Ghazaleh; Becker-Flegler, Katrin; Tripal, Philipp; Staedtler, Sven; Ackermann, Teresa F.; Van Brederode, Johannes; Alzheimer, Christian; Weller, Michael; Lang, Undine E.; Kleuser, Burkhard; Grassmé, Heike; Kornhuber, Johannes
    Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs
    In: Nature Medicine Jg. 19 (2013) Nr. 7, S. 934 - 938
    Online Volltext: dx.doi.org/
  • Grassmé, Heike; Becker, Katrin; Gulbins, Erich
    Wirkungsvolle Lipide : Sphingolipide, bakterielle Infektionen und zystische Fibrose
    In: Unikate: Berichte aus Forschung und Lehre (2013) Nr. 44: Medizin: 50 Jahre Universitätsklinikum Essen, S. 22 - 31
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Becker-Flegler, Katrin; Henry, Brian; Ziobro, Regan; Tümmler, Burkhard; Gulbins, Erich; Grassmé, Heike
    Role of CD95 in pulmonary inflammation and infection in cystic fibrosis
    In: Journal of Molecular Medicine Jg. 90 (2012) Nr. 9, S. 1011 - 1023
    Online Volltext: dx.doi.org/
  • Becker, Katrin Anne; Tümmler, Burkhard; Gulbins, Erich; Grassmé, Heike
    Accumulation of ceramide in the trachea and intestine of cystic fibrosis mice causes inflammation and cell death
    In: Biochemical and Biophysical Research Communications (BBRC) Jg. 403 (2010) Nr. 3-4, S. 368 - 374
    Online Volltext: dx.doi.org/
  • Zhang, Yang; Li, Xiang; Grassmé, Heike; Döring, Gerd; Gulbins, Erich
    Alterations in Ceramide Concentration and pH Determine the Release of Reactive Oxygen Species by Cftr-Deficient Macrophages on Infection
    In: The Journal of Immunology (JI) Jg. 184 (2010) Nr. 9, S. 5104 - 5111
    Online Volltext: dx.doi.org/
  • Grassmé, Heike; Becker-Flegler, Katrin; Zhang, Yang; Gulbins, Erich
    CFTR-dependent susceptibility of the cystic fibrosis-host to Pseudomonas aeruginosa
    In: International Journal of Medical Microbiology (IJMM) Jg. 300 (2010) Nr. 8, S. 578 - 583
    Online Volltext: dx.doi.org/
  • Becker, Katrin Anne; Grassmé, Heike; Zhang, Yang; Gulbins, Erich
    Ceramide in pseudomonas aeruginosa infections and cystic fibrosis
    In: Cellular Physiology and Biochemistry Jg. 26 (2010) Nr. 1, S. 57 - 66
    Online Volltext: dx.doi.org/ (Open Access)
  • Gulbins, Erich; Sassi, Nicola; Grassmè, Heike; Zoratti, Mario; Szabò, Ildikò
    Role of Kv1.3 mitochondrial potassium channel in apoptotic signalling in lymphocytes
    In: Biochimica et Biophysica Acta (BBA) - Bioenergetics Jg. 1797 (2010) Nr. 6-7, S. 1251 - 1259
    Online Volltext: dx.doi.org/ (Open Access)
  • Teichgräber, Volker; Ulrich, Martina; Endlich, Nicole; Riethmüller, Joachim; Wilker, Barbara; De Oliveira-Munding, Cheyla Conceição; Van Heeckeren, Anna M.; Barr, Mark L.; Von Kürthy, Gabriele; Schmid, Kurt Werner; Weller, Michael; Tümmler, Burkhard; Lang, Florian; Grassme, Heike; Döring, Gerd; Gulbins, Erich
    Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis
    In: Nature Medicine Jg. 14 (2008) Nr. 4, S. 382 - 391
    Online Volltext: dx.doi.org/ (Open Access)

    • Beiträge in Sammelwerken und Tagungsbänden

  • Grassmé, Heike; Becker, Katrin Anne
    Bacterial infections and ceramide
    In: Sphingolipids in Disease / Gulbins, Erich; Petrache, Irina 2013, S. 305 - 320
    Online Volltext: dx.doi.org/
  • Grassmé, Heike; Riethmüller, Joachim; Gulbins, Erich
    Ceramide in cystic fibrosis
    In: Sphingolipids in Disease / Gulbins, Erich; Petrache, Irina 2013, S. 265 - 274
    Online Volltext: dx.doi.org/