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Wissenschaftliche/r Mitarbeiter/in, Institut für Zellbiologie (Tumorforschung)
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Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
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Elevated NLRP3 Inflammasome Activation Is Associated with Motor Neuron Degeneration in ALSIn: Cells Jg. 13 (2024) Nr. 12, 995Online Volltext: dx.doi.org/ (Open Access)
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German radiation oncology’s next generation : A web-based survey of young biologists, medical physicists, and physicians — from problems to solutionsIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics (2024) in pressOnline Volltext: dx.doi.org/ (Open Access)
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Metabolic pathway-based subtypes associate glycan biosynthesis and treatment response in head and neck cancerIn: npj Precision Oncology Jg. 8 (2024) Nr. 1, 116Online Volltext: dx.doi.org/ (Open Access)
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α-Ketoglutarate supplementation and NAD+ modulation enhance metabolic rewiring and radiosensitization in SLC25A1 inhibited cancer cellsIn: Cell Death Discovery Jg. 10 (2024) Nr. 1, 27Online Volltext: dx.doi.org/ (Open Access)
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A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in GlioblastomaIn: Clinical Cancer Research Jg. 29 (2023) Nr. 2, S. 488 - 500Online Volltext: dx.doi.org/ (Open Access)
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Cigarette smoke causes a bioenergetic crisis in RPE cells involving the downregulation of HIF-1α under normoxiaIn: Cell Death Discovery Jg. 9 (2023) Nr. 1, 398Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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The second PI(3,5)P₂binding site in the S0 helix of KCNQ1 stabilizes PIP₂-at the primary PI1 site with potential consequences on intermediate-to-open state transitionIn: Biological Chemistry Jg. 404 (2023) Nr. 4,Online Volltext: dx.doi.org/
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Accumulation of oncometabolite D-2-Hydroxyglutarate by SLC25A1 inhibition: A metabolic strategy for induction of HR-ness and radiosensitivityIn: Cell Death and Disease Jg. 13 (2022) Nr. 7, 641Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reactionIn: Cell Death and Disease Jg. 13 (2022) Nr. 7, 662Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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ROS scavengers decrease γH2ax spots in motor neuronal nuclei of ALS model mice in vitroIn: Frontiers in Cellular Neuroscience Jg. 16 (2022) 963169Online Volltext: dx.doi.org/ (Open Access)
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Targeting AKT-Dependent Regulation of Antioxidant Defense Sensitizes AKT-E17K Expressing Cancer Cells to Ionizing RadiationIn: Frontiers in Oncology Jg. 12 (2022) 920017Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Adaptation to chronic-cycling hypoxia renders cancer cells resistant to mth1-inhibitor treatment which can be counteracted by glutathione depletionIn: Cells Jg. 10 (2021) Nr. 11, 3040Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Increased ROS-Dependent Fission of Mitochondria Causes Abnormal Morphology of the Cell Powerhouses in a Murine Model of Amyotrophic Lateral SclerosisIn: Oxidative Medicine and Cellular Longevity Jg. 2021 (2021) 6924251Online Volltext: dx.doi.org/ (Open Access)
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Metabolic reprograming of antioxidant defense : A precision medicine perspective for radiotherapy of lung cancer?In: Biochemical Society Transactions Jg. 49 (2021) Nr. 3, S. 1265 - 1277Online Volltext: dx.doi.org/
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Metabolism of cancer cells commonly responds to irradiation by a transient early mitochondrial shutdownIn: iScience Jg. 24 (2021) Nr. 11, 103366Online Volltext: dx.doi.org/ (Open Access)
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A new twist in protein kinase b/akt signaling : Role of altered cancer cell metabolism in akt-mediated therapy resistanceIn: International Journal of Molecular Sciences (IJMS) Jg. 21 (2020) Nr. 22, S. 8563Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Oncometabolites and the response to radiotherapyIn: Radiation Oncology Jg. 15 (2020) S. 197Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Proton Irradiation Increases the Necessity for Homologous Recombination Repair Along with the Indispensability of Non-Homologous End JoiningIn: Cells Jg. 9 (2020) Nr. 4, S. 889Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Oxidative stress: the lowest common denominator of multiple diseasesIn: Neural Regeneration Research Jg. 14 (2019) Nr. 2, S. 238 - 241Online Volltext: dx.doi.org/ (Open Access)
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Sequence-dependent cross-resistance of combined radiotherapy plus BRAFV⁶⁰⁰E inhibition in melanomaIn: European Journal of Cancer (EJC) Jg. 109 (2019) S. 137 - 153Online Volltext: dx.doi.org/
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Targeting SLC25A10 alleviates improved antioxidant capacity and associated radioresistance of cancer cells induced by chronic-cycling hypoxiaIn: Cancer Letters Jg. 439 (2018) S. 24 - 38Online Volltext: dx.doi.org/
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The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeostasis and Mitochondrial Metabolism Supporting Radioresistance of Cancer Cells With Tolerance to Cycling Severe HypoxiaIn: Frontiers in Oncology Jg. 8 (2018) S. 170Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Role of SGK1 for fatty acid uptake, cell survival and radioresistance of NCI-H460 lung cancer cells exposed to acute or chronic cycling severe hypoxiaIn: Radiation Oncology Jg. 11 (2016) Nr. 1, S. 75 - 87Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Targeted Inhibition of Glutamine-Dependent Glutathione Metabolism Overcomes Death Resistance Induced by Chronic Cycling HypoxiaIn: Antioxidants and Redox Signaling Jg. 25 (2016) Nr. 2, S. 89 - 107Online Volltext: dx.doi.org/
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The Natural Plant Product Rottlerin Activates Kv7.1/KCNE1 ChannelsIn: Cellular Physiology and Biochemistry Jg. 40 (2016) Nr. 6, S. 1549 - 1558Online Volltext: dx.doi.org/ (Open Access)
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Chronic intermittent hypoxia triggers adaptive changes that promote protection against cell deathIn: European Journal of Cancer (EJC) Jg. 49 (2013) Nr. Suppl. 2, S. 101Online Volltext: dx.doi.org/
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Defects in DNA Damage Response Reinforce Proton Beam Specific Radiosensitivity of Cancer CellsIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics Jg. 199 (2023) Nr. Suppl. 1, S. S36 - S37Online Volltext: dx.doi.org/ (Open Access)
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Cross-talk of radiotherapy-induced mitochondrial impairment and resulting metabolic reprogramming impact DNA DSB repair capacity
ESTRO 2022: Learning from every patient, 6-10 May 2022, Copenhagen,In: Radiotherapy and Oncology (The Green Journal) Jg. 170 (2022) Nr. Supplement 1: ESTRO 2022, 6-10 May 2022, Copenhagen. Onsite in Copenhagen and Online, S. S307Online Volltext: dx.doi.org/ -
KDM5B's role in creating radiation synthetic vulnerabilities and its effects on sequential therapy combinations
48th Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF): Virtual, Innsbruck, 23-26 February 2022,In: Experimental Dermatology Jg. 31 (2022) Nr. 2, S. e9 - e10Online Volltext: dx.doi.org/ -
Ensuring fuels for DNA repair : Analysis of irradiated cancer cells reveals mitochondrial shutdownIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics Jg. 197 (2021) Nr. Suppl. 1, S. 200
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Modeling common aspects of the metabolic response of cancer cells to ionizing radiationIn: Cancer Research Jg. 81 (2021) Nr. 13, 3065
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The Role of KDM5B in the Development of radiation-synthetic Vulnerability and its Effect on sequential Therapy CombinationsIn: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) Jg. 19 (2021) Nr. Suppl. 4, S. 74
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The citrate carrier SLC25A1 acts as master regulator of metabolic reprogramming and offers an innovative strategy for metabolic induction of HRness and synthetic lethality approaches with radiotherapyIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics Jg. 197 (2021) Nr. Suppl. 1, S. 48 - S49
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Inhibition of the mitochondrial citrate carrier SLC25A1 induces a DNA repair defect and increases cancer cell radiosensitivity
26. Jahrestagung der Deutschen Gesellschaft für Radioonkologie (DEGRO) ; 24. - 28. Juni 2020, Wiesbaden, Germany,In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics Jg. 196 (2020) Nr. 1 Supplement: Abstracts DEGRO 2020, S. S184Online Volltext: dx.doi.org/ (Open Access) -
Combined inhibition of GSH levels and sanitization of dNTPs is effective in eradicating cancer cells exposed to acute hypoxia or chronic cycling severe hypoxiaIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics Jg. 194 (2018) Nr. Suppl. 1, S. 172Online Volltext: dx.doi.org/ (Open Access)
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Targeting of antioxidant-associated mitochondrial transport systems overcomes chronic-cycling hypoxia-induced radioresistance
33. Deutscher Krebskongress - Perspektiven verändern Krebs - Krebs verändert Perspektiven. Diagnose - Therapie - (Über-)Leben ; Berlin, 21.-24. Februar 2018,In: Oncology Research and Treatment Jg. 41 (2018) Nr. Suppl. 1, S. 150Online Volltext: dx.doi.org/ (Open Access) -
Targeting of the mitochondrial citrate carrier (SLC25A1) lowers antioxidant defense systems and increases radiosensitivity of hypoxic cancer cellsIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics Jg. 194 (2018) Nr. Suppl. 1, S. 30Online Volltext: dx.doi.org/ (Open Access)
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Senescence-like responses in irradiated melanoma cellsIn: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) Jg. 13 (2015) Nr. Suppl.2, S. 34Online Volltext: dx.doi.org/
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Chronic intermittent hypoxia triggers adaptive changes that promote protection against cell deathIn: European Journal of Cancer (EJC) Jg. 50 (2014) Nr. Suppl. 5, S. 51Online Volltext: dx.doi.org/
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Dihydroartemisinin exerts context-dependent lethal effects in combination with ionizing radiation
19. Jahreskongress der Deutschen Gesellschaft für Radioonkologie; 9. bis 12. Mai 2013, Berlin,In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics Jg. 189 (2013) Nr. SUPPL. 1, S. 128 - 129Online Volltext: dx.doi.org/ -
Metabolische Abhängigkeiten als molekulare Zielstruktur zur Überwindung der StrahlenresistenzDuisburg ; Essen (2024) 1 CD-ROM
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Inhibierung der AKT-abhängigen Regulation der antioxidant defense erhöht die Radiosensitivität von Krebszellen
28. Kongress der Deutschen Gesellschaft für Radioonkologie ; DEGRO 2022 ; 26. bis 28.05.2022, Stuttgart, Germany,In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics Jg. 198 (2022) Nr. Supplement 1, S. S157Online Volltext: dx.doi.org/ (Open Access) -
The citrate carrier SLC25A1 acts as regulator of metabolic reprogramming offering an innovative strategy for synthetic lethality approaches with radiotherapy
28. Kongress der Deutschen Gesellschaft für Radioonkologie ; DEGRO 2022 ; 26. bis 28.05.2022, Stuttgart, Germany,In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics Jg. 198 (2022) Nr. Supplement 1, S. S152 - S153Online Volltext: dx.doi.org/ (Open Access) -
Abstract PO-022: Inhibition of the citrate carrier SLC25A1 affects repair of radiation-induced DNA damage, increases radiosensitivity, and enhances lethality of IR in combination with DNA repair defects or DSB inhibitors
AACR Virtual Special Conference on Radiation Science and Medicine; March 2-3, 2021, Online,In: Clinical Cancer Research Jg. 27 (2021) Nr. 8, Supplement, S. PO - 022Online Volltext: dx.doi.org/