Publications

GRK 2098 (2015-2018 & 2018-2021)

GRK2098:

Naser E, Kadow S, Schumacher F, Mohamed ZH, Kappe C, Hessler G, Pollmeier B, Kleuser B, Arenz C, Becker KA, Gulbins E, Carpinteiro A. Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro. J Lipid Res. 2020 Jun;61(6):896-910. doi: 10.1194/jlr.RA120000682. Epub 2020 Mar 10. PMID: 32156719; PMCID: PMC7269768.

Plöhn S, Hose M, Schlüter A, Michel L, Diaz-Cano SJ, Hendgen-Cotta U, Banga JP, Bechrakis N, Hansen W, Eckstein A, Berchner-Pfannschmidt U. Fingolimod improves the outcome of experimental Graves' disease and associated orbitopathy by modulating the autoimmune response to the thyroid stimulating hormone receptor. Thyroid. 2019 Jun 25. doi: 10.1089/thy.2018.0754. [Epub ahead of print]

Hose M, Günther A, Abberger H, Begum S, Korencak M, Becker KA, Buer J, Westendorf AM, Hansen W. T Cell-specific overexpression of acid sphingomyelinase results in elevated T Cell activation and reduced parasitemia during plasmodium yoelii Infection. Front Immunol, 2019 vol. 10 pp. 1225

 Meiners M, Palmieri V, Klopfleisch R, Ebel JF, Japtok L, Schumacher F, Yusuf AM, Becker K.A., Zöller J, Hose M, Kleuser B, Hermann DM, Kolesnick R, Buer J, Hansen W, Westendorf A M. Intestinal acid sphingomyelinase protects from severe pathogen driven colitis. Front Immunol. 2019 June 19; doi:10.3389/fimmu.2019.01386

 Plöhn S, Edelmann B, Japtok L, He X, Hose M, Hansen W, Schuchman EH, Eckstein A, Berchner-Pfannschmidt U. CD40 Enhances Sphingolipids in Orbital Fibroblasts: Potential Role of Sphingosine-1-Phosphate in Inflammatory T-Cell Migration in Graves' Orbitopathy. Invest Ophthalmol Vis Sci. 2018 Nov 1;59(13):5391-5397. doi: 10.1167/iovs.18-25466.

Wu Y, Gulbins E, Grassmé H. The function of sphingomyelinases in mycobacterial infections. Biol Chem. 2018 Sep 25;399(10):1125-1133. doi: 10.1515/hsz-2018-0179. Review. PubMed PMID: 29924725.

Wu Y, Gulbins E, Grassmé H. Crosstalk Between Sphingomyelinases and Reactive Oxygen Species in Mycobacterial Infection. Antioxid Redox Signal. 2017 Apr 6. doi: 10.1089/ars.2017.7050. [Epub ahead of print] PubMed PMID: 28276697

 Außerhalb des GRK2098:

Loevenich K.; Ueffing K.; Abel S.; Hose M.; Matuschewski K.; Westendorf A.M.; Buer J.; Hansen W. DC-Derived IL-10 Modulates Pro-inflammatory Cytokine production and Promotes Induction of CD4+ IL-10 10+ Regulatory T cells during Plasmodium yoelii Infection. Front Immunol. 2017; 8:152. doi 10.3389/fimmu. 2017.00152.

 Abel S, Ueffing K, Tatura R, Hutzler M, Hose M, Matuschewski K, Kehrmann J, Westendorf AM, Buer J, Hansen W. 2016. Plasmodium yoelii infection of BALB/c mice results in expansion rather than induction of CD4+ Foxp3+ regulatory T cells. Immunology 148: 197-205.