Cancer and the Asm/ceramide pathway Project area I

P01: The role of acid sphingomyelinase (Asm) in T cell responses during tumor development and radiation treatment
Prof. Dr. Wiebke Hansen / Prof. Dr. Jan Buer / Prof. Dr. Adriana Haimovitz-Friedman

P02: Sphingolipid signals regulate hypoxia inducible factor 1 in endothelial cells and macrophages after single-dose radiation therapy
Prof. Dr. Joachim Fandrey / Prof. Dr. Adriana Haimovitz-Friedman / Prof. Dr. Zvi Fuks

P03: Signaling via ceramide-enriched membrane platforms
Dr. Katrin A. Becker-Flegler / Prof Dr. Adriana Heimovitz-Friedman

Inflammation, bacterial infection and the Asm/ceramide pathway Project area II

P04: Role of acid sphingomyelinase in experimental inflammatory bowel disease
Prof. Dr. Astrid M. Westendorf / Prof. Dr. Richard Kolesnick

P05: Molecular mechanisms of altered sphingolipid homeostasis in Graves’ Orbitopathy
Prof. Dr. Anja Eckstein / PD Dr. Utta Berchner-Pfannschmidt / Prof. Dr. Edward Schuchman

P06: Role of acid sphingomyelinase in mycobacterial infections
Prof. Dr. Karl S. Lang / Dr. Heike Grassmé / Prof. Dr. Fred Maxfield

P07: Preventing infection in cystic fibrosis with acid ceramidase
Prof. Dr. Erich Gulbins / Prof. Dr. Edward Schuchman

Cardiovascular and immunological functions of S1P Project area III

P08: Role of ceramide-rich macrodomains in regulating ABC transporters post ischemia
Prof. Dr. Dirk M. Herrmann / Prof. Dr. Zvi Fuks / Prof. Dr. Richard Kolesnick

P09: Sphingosine-1-Phosphate (S1P) in arterial remodeling and aneurysm formation
Dr. Petra Keul / Prof. Dr. Timothy Hla

P10: Sphingosine-1-phosphate (S1P) as a causal factor for impaired function of highdensity lipoproteins (HDL) in patients with coronary artery disease (CAD)
Prof. Dr. Bodo Levkau I / Prof. Dr. Timothy Hla

P11: Trafficking of sphingosine-1-phosphate (S1P) between cells and high-density lipoproteins as crucial component of S1P signalling and lipid transfer
Prof. Dr. Bodo Levkau II / Prof. Dr. Anant Menon