Dr. rer. nat. Roland Schwarzer

Professional Experience

Group Leader

Institute for Translational HIV Research

January 2021-present

Essen, Germany

Scientist

Gladstone Center for HIV Cure Research

July 2019-Dec 2020

San Francisco, CA

Postdoc​toral fellow

Gladstone Center for HIV Cure Research

July 2016-July 2019

San Francisco, CA

Postdoctoral fellow

Weizmann Institute of Science - Department of Biomolecular Sciences

Sep 2014-Mar 2016

Rehovot, Israel

Academic staff member

Charité, University Hospital - Institute of Virology

Jan 2014-July 2014

Berlin, Germany

Doctoral candidate

Humboldt University - Molecular Biophysics

July 2009-Dec 2013

Berlin, Germany

Graduating student

Humboldt University - Molecular Biophysics

May 2008-May 2009

Berlin, Germany

Education and Degrees

Dr. rer. nat. Experimental Biophysics

Humboldt University

July 2009-June 2013

Berlin, Germany

Diploma Biophysics

Humboldt University

May 2008-May 2009

Berlin, Germany

Undergraduate Student

Humboldt University                                                                                                  

October 2004- July 2009

Berlin, Germany

Publications

    Journal articles

  • Shahhamzehei, Nasim; Abdelfatah, Sara; Schwarzer-Sperber, Hannah S.; Sutter, Kathrin; Yücer, Rümeysa; Bringmann, Gerhard; Schwarzer, Roland; Efferth, Thomas
    Identification of nitrile-containing isoquinoline-related natural product derivatives as coronavirus entry inhibitors in silico and in vitro
    In: Biomedicine & Pharmacotherapy Vol. 180 (2024) 117517
    Online Full Text: dx.doi.org/ (Open Access)
  • Menke, Laura; Sperber, Hannah S; Aji, Amit Koikkarah; Chiantia, Salvatore; Schwarzer, Roland; Sieben, Christian
    Advances in fluorescence microscopy for orthohantavirus research
    In: Microscopy Vol. 72 (2023) Nr. 3, pp. 191 - 203
    Online Full Text: dx.doi.org/ (Open Access)
  • B Narayanan, Vedha Hari; Kost, Bartłomiej; Lewandowski, Artur; Durai, Ramya Devi; Wawrzyniak, Paweł; Biela, Tadeusz; Wingenfeld, Rieke; Sabeth Sperber, Hannah; Schwarzer, Roland; Brzeziński, Marek
    PLA stereocomplex-chitosan nanoparticles loaded with tenofovir alafenamide as a long-acting antiretrovirals
    In: Advanced Powder Technology Vol. 34 (2023) Nr. 11, 104205
    Online Full Text: dx.doi.org/
  • Sperber, Hannah S.; Raymond, Kyle A.; Bouzidi, Mohamed S.; Ma, Tongcui; Valdebenito, Silvana; Eugenin, Eliseo A.; Roan, Nadia R.; Deeks, Steven G.; Winning, Sandra; Fandrey, Joachim; Schwarzer, Roland; Pillai, Satish K.
    The hypoxia-regulated ectonucleotidase CD73 is a host determinant of HIV latency
    In: Cell Reports Vol. 42 (2023) Nr. 11, 113285
    Online Full Text: dx.doi.org/ (Open Access)
  • Ettich, Julia; Werner, Julia; Weitz, Hendrik T.; Mueller, Eva; Schwarzer, Roland; Lang, Philipp A.; Scheller, Jürgen; Moll, Jens M.
    A Hybrid Soluble gp130/Spike-Nanobody Fusion Protein Simultaneously Blocks Interleukin-6 trans-Signaling and Cellular Infection with SARS-CoV-2
    In: Journal of Virology Vol. 96 (2022) Nr. 4, e01622-21
    Online Full Text: dx.doi.org/ (Open Access)
  • Packard, Thomas A.; Schwarzer, Roland; Herzig, Eytan; Rao, Deepashri; Luo, Xiaoyu; Egedal, Johanne H.; Hsiao, Feng; Widera, Marek; Hultquist, Judd F.; Grimmett, Zachary W.; Messer, Ronald J.; Krogan, Nevan J.; Deeks, Steven G.; Roan, Nadia R.; Dittmer, Ulf; Hasenkrug, Kim J.; Greene, Warner C.
    CCL2 : a Chemokine Potentially Promoting Early Seeding of the Latent HIV Reservoir
    In: mBio Vol. 13 (2022) Nr. 5, e0189122
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Welke, Robert-William; Sperber, Hannah Sabeth; Bergmann, Ronny; Koikkarah, Amit; Menke, Laura; Sieben, Christian; Krüger, Detlev H.; Chiantia, Salvatore; Herrmann, Andreas; Schwarzer, Roland
    Characterization of Hantavirus N Protein Intracellular Dynamics and Localization
    In: Viruses Vol. 14 (2022) Nr. 3, 457
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Klug, Yoel A.; Schwarzer, Roland; Ravula, Thirupathi; Rotem, Etai; Ramamoorthy, Ayyalusamy; Shai, Yechiel
    Structural and Mechanistic Evidence for Calcium Interacting Sites in the HIV Transmembrane Protein gp41 Involved in Membrane Fusion
    In: Biochemistry Vol. 61 (2022) Nr. 17, pp. 1915 - 1922
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Sperber, Hannah Sabeth; Sutter, Kathrin; Müller, Karin; Müller, Peter; Schwarzer, Roland
    The Bovine Seminal Plasma Protein PDC-109 Possesses Pan-Antiviral Activity
    In: Viruses Vol. 14 (2022) Nr. 9, 2031
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Gramatica, Andrea; Schwarzer, Roland; Brantley, William; Varco-Merth, Benjamin; Sperber, Hannah S.; Hull, Philip A.; et.al.
    Evaluating a New Class of AKT/mTOR Activators for HIV Latency-Reversing Activity Ex Vivo and In Vivo
    In: Journal of Virology Vol. 95 (2021) Nr. 8, pp. e02393 - 20
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Bauherr, Sandy; Larsberg, Filip; Petrich, Annett; Sperber, Hannah Sabeth; Klose-Grzelka, Victoria; Luckner, Madlen; Azab, Walid; Schade, Matthias; Höfer, Chris Tina; Lehmann, Maik Joerg; Witkowski, Peter T.; Krüger, Detlev H.; Herrmann, Andreas; Schwarzer, Roland
    Macropinocytosis and clathrin-dependent endocytosis play pivotal roles for the infectious entry of puumala virus
    In: Journal of Virology Vol. 94 (2020) Nr. 14,
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Schwarzer, Roland; Gramatica, Andrea; Greene, Warner C.
    Reduce and control : A combinatorial strategy for achieving sustained HIV remissions in the absence of antiretroviral therapy
    In: Viruses Vol. 12 (2020) Nr. 2, 188
    Online Full Text: dx.doi.org/ (Open Access)
  • Hsiao, Feng; Frouard, Julie; Gramatica, Andrea; Xie, Guorui; Telwatte, Sushama; Lee, Guinevere Q.; Roychoudhury, Pavitra; Schwarzer, Roland; Luo, Xiaoyu; Yukl, Steven A.; Lee, Sulggi; Hoh, Rebecca; Deeks, Steven G.; Brad Jones, R.; Cavrois, Marielle; Greene, Warner C.; Roan, Nadia R.; Jones, R. Brad
    Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection
    In: PLoS Pathogens Vol. 16 (2020) Nr. 4, pp. e1008450
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Herzig, Eytan; Kim, Kaman Chan; Packard, Thomas A.; Vardi, Noam; Schwarzer, Roland; Gramatica, Andrea; Deeks, Steven G.; Williams, Steven R.; Landgraf, Kyle; Killeen, Nigel; Martin, David W.; Weinberger, Leor S.; Greene, Warner C.
    Attacking Latent HIV with convertibleCAR-T Cells, a Highly Adaptable Killing Platform
    In: Cell Vol. 179 (2019) Nr. 4, pp. 880 - 894.e10
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Sperber, Hannah Sabeth; Welke, Robert-William; Petazzi, Roberto Arturo; Bergmann, Ronny; Schade, Matthias; Shai, Yechiel; Chiantia, Salvatore; Herrmann, Andreas; Schwarzer, Roland
    Self-association and subcellular localization of Puumala hantavirus envelope proteins
    In: Scientific Reports Vol. 9 (2019) Nr. 1, pp. 707
    Online Full Text: dx.doi.org/ (Open Access)
  • Klug, Yoel A.; Schwarzer, Roland; Rotem, Etai; Charni, Meital; Nudelman, Alon; Gramatica, Andrea; Zarmi, Batya; Rotter, Varda; Shai, Yechiel
    The HIV gp41 Fusion Protein Inhibits T-Cell Activation through the Lentiviral Lytic Peptide 2 Motif
    In: Biochemistry Vol. 58 (2019) Nr. 6, pp. 818 - 832
    Online Full Text: dx.doi.org/
  • Yakovian, Oren; Schwarzer, Roland; Sajman, Julia; Neve-Oz, Yair; Razvag, Yair; Herrmann, Andreas; Sherman, Eilon
    Gp41 dynamically interacts with the TCR in the immune synapse and promotes early T cell activation
    In: Scientific Reports Vol. 8 (2018) Nr. 1, pp. 9747
    Online Full Text: dx.doi.org/ (Open Access)
  • Denz, Manuela; Chiantia, Salvatore; Herrmann, Andreas; Mueller, Peter; Korte, Thomas; Schwarzer, Roland
    Cell cycle dependent changes in the plasma membrane organization of mammalian cells
    In: Biochimica et Biophysica Acta (BBA) - Biomembranes Vol. 1859 (2017) Nr. 3, pp. 350 - 359
    Online Full Text: dx.doi.org/ (Open Access)
  • Klug, Yoel A.; Rotem, Etai; Schwarzer, Roland; Shai, Yechiel
    Mapping out the intricate relationship of the HIV envelope protein and the membrane environment
    In: Biochimica et Biophysica Acta (BBA) - Biomembranes Vol. 1859 (2017) Nr. 4, pp. 550 - 560
    Online Full Text: dx.doi.org/ (Open Access)
  • Boehm, Daniela; Jeng, Mark; Camus, Gregory; Gramatica, Andrea; Schwarzer, Roland; Johnson, Jeffrey R.; Hull, Philip A.; Montano, Mauricio; Sakane, Naoki; Pagans, Sara; Godin, Robert; Deeks, Steven G.; Krogan, Nevan J.; Greene, Warner C.; Ott, Melanie
    SMYD2-Mediated Histone Methylation Contributes to HIV-1 Latency
    In: Cell Host & Microbe Vol. 21 (2017) Nr. 5, pp. 569 - 579.e6
    Online Full Text: dx.doi.org/ (Open Access)
  • Schwarzer, Roland; Sperber, Hannah; Paulick, Katharina
    Automatische Bildanalyse für Histologie und Immunhistochemie
    In: Biospektrum Vol. 22 (2016) Nr. 7, pp. 720 - 723
    Online Full Text: dx.doi.org/
  • Scolari, Silvia; Imkeller, Katharina; Jolmes, Fabian; Veit, Michael; Herrmann, Andreas; Schwarzer, Roland
    Modulation of cell surface transport and lipid raft localization by the cytoplasmic tail of the influenza virus hemagglutinin
    In: Cellular Microbiology Vol. 18 (2016) Nr. 1, pp. 125 - 136
    Online Full Text: dx.doi.org/ Online Full Text
  • Lauster, Daniel; Vazquez, Olalla; Schwarzer, Roland; Seitz, Oliver; Herrmann, Andreas
    Potential of proapoptotic peptides to induce the formation of giant plasma membrane vesicles with lipid domains
    In: ChemBioChem Vol. 16 (2015) Nr. 9, pp. 1288 - 1292
    Online Full Text: dx.doi.org/
  • Haralampiev, Ivan; Mertens, Monique; Schwarzer, Roland; Herrmann, Andreas; Volkmer, Rudolf; Wessig, Pablo; Müller, Peter
    Recruitment of SH-containing peptides to lipid and biological membranes through the use of a palmitic acid functionalized with a maleimide group
    In: Angewandte Chemie International Edition Vol. 54 (2015) Nr. 1, pp. 323 - 326
    Online Full Text: dx.doi.org/
  • Nickel, N.; Godau, J.; Willie, B.M.; Duda, G.N.; Schwarzer, Roland; Cirovic, B.; Leutz, A.; Manz, R.; Bogen, B.; Dörken, B.; Jundt, F.
    Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM model
    In: Blood Cancer Journal Vol. 4 (2014) Nr. 6, pp. e217
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Reuven, Eliran Moshe; Ali, Mohammad; Rotem, Etai; Schwarzer, Roland; Gramatica, Andrea; Futerman, Anthony H.; Shai, Yechiel
    The HIV-1 Envelope Transmembrane Domain Binds TLR2 through a Distinct Dimerization Motif and Inhibits TLR2-Mediated Responses
    In: PLoS Pathogens Vol. 10 (2014) Nr. 8,
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Schwarzer, Roland; Levental, Ilya; Gramatica, Andrea; Scolari, Silvia; Buschmann, Volker; Veit, Michael; Herrmann, Andreas
    The cholesterol-binding motif of the HIV-1 glycoprotein gp41 regulates lateral sorting and oligomerization
    In: Cellular Microbiology Vol. 16 (2014) Nr. 10, pp. 1565 - 1581
    Online Full Text: dx.doi.org/
  • Heek, Timm; Nikolaus, Jörg; Schwarzer, Roland; Fasting, Carlo; Welker, Pia; Licha, Kai; Herrmann, Andreas; Haag, Rainer
    An amphiphilic perylene imido diester for selective cellular imaging
    In: Bioconjugate Chemistry Vol. 24 (2013) Nr. 2, pp. 153 - 158
    Online Full Text: dx.doi.org/
  • Milles, Sigrid; Meyer, Thomas; Scheidt, Holger A.; Schwarzer, Roland; Thomas, Lars; Marek, Magdalena; Szente, Lajos; Bittman, Robert; Herrmann, Andreas; Günther Pomorski, Thomas; Huster, Daniel; Müller, Peter
    Organization of fluorescent cholesterol analogs in lipid bilayers - Lessons from cyclodextrin extraction
    In: Biochimica et Biophysica Acta (BBA) - Biomembranes Vol. 1828 (2013) Nr. 8, pp. 1822 - 1828
    Online Full Text: dx.doi.org/ (Open Access)
  • Wawrzinek, Robert; Wessig, Pablo; Möllnitz, Kristian; Nikolaus, Jörg; Schwarzer, Roland; Müller, Peter; Herrmann, Andreas
    DBD dyes as fluorescent probes for sensing lipophilic environments
    In: Bioorganic and Medicinal Chemistry Letters Vol. 22 (2012) Nr. 17, pp. 5367 - 5371
    Online Full Text: dx.doi.org/

    • Abstracts

  • Kruth, Carolin; Schwarzer-Sperber, Hannah; Esser, Stefan; Dittmer, Ulf; Schwarzer, Roland; Sutter, Kathrin;
    Effects of type I interferons on HIV latency
    DÖAK 2023 / German-Austrian AIDS Conference, Bonn, Germany, 23-25 March 2023,
    In: HIV Medicine Vol. 24 (2023) Nr. S1, pp. 82