Alireza Doustmohammadi

Alireza

PhD candidate in Computational Biomedicine

Affiliated with:

Farahpour Lab
Department of Bioinformatics and Computational Biophysics

alireza.dostmohammadi[at]uni-due.de

Faculty of Biology, University of Duisburg-Essen, Universitätsstr. 2, 45141 Essen

+49 201 183 3092

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Publications


Research Summary

Reciprocal interactions between the tumor microenvironment and the lesional microbiome
Mycosis fungoides (MF), the most prevalent cutaneous T-cell lymphoma, is characterized by malignant T-cell proliferation within a chronic inflammatory environment with variable disease progression from indolent to aggressive forms. Our hypothesis is that the interaction between malignant and reactive T cells in MF lesions is influenced by the microbiome, thereby affecting disease progression. Our research aims to link these interactions with the microbiome to identify prognostic markers and develop novel therapies.
Methods: Immune repertoire analysis, Microbial read detection, Microbial functional analysis, Cell-Cell communication.
Funded by: DFG