Publications
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Glycosaminoglycans exhibit distinct interactions and signaling with BMP2 according to their nature and localizationIn: Carbohydrate Polymers Vol. 341 (2024) 122294Online Full Text: dx.doi.org/ (Open Access)
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Epigenetic mechanisms mediating cell state transitions in chondrocytesIn: Journal of Bone and Mineral Research (JBMR) Vol. 36 (2021) Nr. 5, pp. 968 - 985Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Heparan sulfate deficiency in cartilage : Enhanced bmp-sensitivity, proteoglycan production and an anti-apoptotic expression signature after loadingIn: International Journal of Molecular Sciences (IJMS) Vol. 22 (2021) Nr. 7, pp. 3726Online Full Text: dx.doi.org/ (Open Access)
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An altered heparan sulfate structure in the articular cartilage protects against osteoarthritisIn: Osteoarthritis and Cartilage Vol. 28 (2020) Nr. 7, pp. 977 - 987Online Full Text: dx.doi.org/ (Open Access)
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Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfateIn: Matrix Biology Vol. 39 (2020) pp. 43 - 59Online Full Text: dx.doi.org/ (Open Access)
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Wnt5a is a transcriptional target of Gli3 and Trps1 at the onset of chondrocyte hypertrophyIn: Developmental Biology Vol. 457 (2020) Nr. 1, pp. 104 - 118Online Full Text: dx.doi.org/ (Open Access)
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A network of trans-cortical capillaries as mainstay for blood circulation in long bonesIn: Nature Metabolism Vol. 1 (2019) Nr. 2, pp. 236 - 250Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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A newly discovered stem cell that keeps bones growingIn: Nature Vol. 567 (2019) Nr. 7747, pp. 178 - 179Online Full Text: dx.doi.org/ (Open Access)
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Atoh8 acts as a regulator of chondrocyte proliferation and differentiation in endochondral bonesIn: PLoS ONE Vol. 14 (2019) Nr. 8, pp. e0218230
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Four-jointed knock-out delays renal failure in an ADPKD model with kidney injuryIn: The Journal of Pathology Vol. 249 (2019) Nr. 1, pp. 114 - 125Online Full Text: dx.doi.org/ (Open Access)
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Signaling systems affecting the severity of multiple osteochondromasIn: Bone: Official Journal of the International Bone and Mineral Society (IBMS) Vol. 111 (2018) pp. 71 - 81Online Full Text: dx.doi.org/ (Open Access)
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Epigenetic regulation of chondrocyte differentiation
18th International Congress of Developmental Biology, 18-22 June, Singapore,In: Mechanisms of Development Vol. 145 (2017) Nr. Supplement: 18th International Congress of Developmental Biology 18-22 June, University Cultural Centre, National University of Singapore, pp. S141Online Full Text: dx.doi.org/ -
OVERLOAD of joints and its role in osteoarthritis : Towards understanding and preventing progression of primary osteoarthritis; English versionIn: Zeitschrift für Rheumatologie Vol. 76 (2017) Nr. Suppl. 1, pp. 1 - 4Online Full Text: dx.doi.org/
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Regulation of calvarial osteogenesis by concomitant de-repression of GLI3 and activation of IHH targetsIn: Frontiers in Physiology Vol. 8 (2017) pp. 1036Online Full Text: dx.doi.org/ (Open Access)
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Altered heparan sulfate structure in Glce-/- mice leads to increased Hedgehog signaling in endochondral bonesIn: Matrix Biology Vol. 49 (2016) pp. 82 - 92Online Full Text: dx.doi.org/
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Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustionIn: Journal of Experimental Medicine (JEM) Vol. 213 (2016) Nr. 12, pp. 2759 - 2772Online Full Text: dx.doi.org/ (Open Access)
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Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling, swelling, and protein cleavageIn: The FASEB Journal Vol. 30 (2016) Nr. 2, pp. 727 - 737Online Full Text: dx.doi.org/
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Anoctamin-6 Controls Bone Mineralization by Activating the Calcium Transporter NCX1In: The Journal of Biological Chemistry (JBC) Vol. 290 (2015) Nr. 10, pp. 6270 - 6280Online Full Text: dx.doi.org/ (Open Access)
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Hypertrophe Chondrozyten : Programmierter Zelltod oder Stammzellreservoir?In: Zeitschrift für Rheumatologie Vol. 74 (2015) Nr. 10, pp. 898 - 901Online Full Text: dx.doi.org/
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Involvement of Ca2+ Activated Cl- Channel Ano6 in Platelet Activation and ApoptosisIn: Cellular Physiology and Biochemistry Vol. 37 (2015) Nr. 5, pp. 1934 - 1944Online Full Text: dx.doi.org/ (Open Access)
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OVERLOAD – Rolle der Gelenküberlastung in der primären Arthrose : Die Krankheitsprogression verstehen und vermeidenIn: Zeitschrift für Rheumatologie Vol. 74 (2015) Nr. 7, pp. 618 - 621Online Full Text: dx.doi.org/
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Sweet on hedgehogs : Regulatory roles of heparan sulfate proteoglycans in hedgehog-dependent cell proliferation and differentiationIn: Current Protein and Peptide Science Vol. 16 (2015) Nr. 1, pp. 66 - 76Online Full Text: dx.doi.org/
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Gene expression profiling reveals similarities between the spatial architectures of postnatal articular and growth plate cartilageIn: PLoS ONE Vol. 9 (2014) Nr. 7, pp. 0103061Online Full Text: dx.doi.org/ (Open Access)
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Heparan sulfate as a regulator of endochondral ossification and osteochondroma developmentIn: Matrix Biology Vol. 34 (2014) pp. 55 - 63Online Full Text: dx.doi.org/ (Open Access)
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Inactivation of Patched1 in murine chondrocytes causes spinal fusion without inflammationIn: Arthritis & Rheumatology Vol. 66 (2014) Nr. 4, pp. 831 - 840Online Full Text: dx.doi.org/
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Reprint of: Heparan sulfate as a regulator of endochondral ossification and osteochondroma developmentIn: Matrix Biology Vol. 35 (2014) pp. 239 - 247Online Full Text: dx.doi.org/ (Open Access)
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Signaling Domain of Sonic Hedgehog as Cannibalistic Calcium-Regulated Zinc-PeptidaseIn: PLoS Computational Biology Vol. 10 (2014) Nr. 7, pp. e1003707Online Full Text: dx.doi.org/ (Open Access)
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Inactivation of anoctamin-6/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissuesIn: Journal of Bone and Mineral Research (JBMR) Vol. 28 (2013) Nr. 2, pp. 246 - 259Online Full Text: dx.doi.org/
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The multi zinc-finger protein Trps1 acts as a regulator of histone deacetylation during mitosisIn: Cell Cycle Vol. 12 (2013) Nr. 14, pp. 2219 - 2232Online Full Text: dx.doi.org/
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Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in miceIn: PLoS ONE Vol. 7 (2012) Nr. 8, pp. e43553Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Loss-of-function of Gli3 in mice causes abnormal frontal bone morphology and premature synostosis of the interfrontal sutureIn: Frontiers in Physiology Vol. 3 (2012) Nr. MAY, pp. 121Online Full Text: dx.doi.org/ (Open Access)
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Prdm5 Regulates Collagen Gene Transcription by Association with RNA Polymerase II in Developing BoneIn: PLoS Genetics Vol. 8 (2012) Nr. 5, pp. e1002711Online Full Text: dx.doi.org/ (Open Access)
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Sonic hedgehog signaling during adrenal developmentIn: Molecular and Cellular Endocrinology Vol. 351 (2012) Nr. 1, pp. 19 - 27Online Full Text: dx.doi.org/
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BMP signaling balances proliferation and differentiation of muscle satellite cell descendants.In: BMC Cell Biology Vol. 12 (2011) pp. 26Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytesIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 107 (2010) Nr. 5, pp. 2054 - 2059Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Expression patterns of sulfatase genes in the developing mouse embryoIn: Developmental Dynamics Vol. 239 (2010) Nr. 6, pp. 1779 - 1788Online Full Text: dx.doi.org/
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Gli2 activator function in preosteoblasts is sufficient to mediate Ihh-dependent osteoblast differentiation, whereas the repressor function of Gli2 is dispensable for endochondral ossification.In: Developmental Dynamics Vol. 239 (2010) Nr. 6, pp. 1818 - 1826Online Full Text: dx.doi.org/
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The resorption of nanocrystalline calcium phosphates by osteoclast-like cellsIn: Acta Biomaterialia Vol. 6 (2010) Nr. 8, pp. 3223 - 3233Online Full Text: dx.doi.org/
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Transcriptional networks controlling chondrocyte proliferation and differentiation during endochondral ossification.In: Pediatric Nephrology Vol. 25 (2010) Nr. 4, pp. 625 - 631Online Full Text: dx.doi.org/
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Widespread regulation of gene expression in the Drosophila genome by the histone acetyltransferase dTip60In: Chromosoma Vol. 119 (2010) Nr. 1, pp. 99 - 113Online Full Text: dx.doi.org/
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Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3In: Developmental Biology Vol. 328 (2009) Nr. 1, pp. 40 - 53Online Full Text: dx.doi.org/
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Follistatin antagonizes transforming growth factor-beta3-induced epithelial-mesenchymal transition in vitro: implications for murine palatal development supported by microarray analysis.In: Differentiation Vol. 76 (2008) Nr. 4, pp. 404 - 416
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Redundant function of the heparan sulfate 6-O-endosulfatases Sulf1 and Sulf2 during skeletal developmentIn: Developmental Dynamics Vol. 2 (2008) Nr. 237, pp. 339 - 353
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Tricho-rhino-phalangeal syndrome with supernumerary teethIn: Journal of Dental Research: JDR Online Vol. 87 (2008) Nr. 11, pp. 1027 - 1031Online Full Text: dx.doi.org/
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Ucma - A novel secreted factor represents a highly specific marker for distal chondrocytesIn: Matrix Biology Vol. 27 (2008) Nr. 1, pp. 3 - 11Online Full Text: dx.doi.org/
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The rodent Four-jointed ortholog Fjx1 regulates dendrite extensionIn: Developmental Biology Vol. 312 (2007) Nr. 1, pp. 461 - 470Online Full Text: dx.doi.org/
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Hedgehog signaling in skeletal developmentIn: Birth Defects Research Part C: Embryo Today, Reviews Vol. 78 (2006) Nr. 3, pp. 267 - 279Online Full Text: dx.doi.org/
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The role of growth factors in chondrogenesis and osteogenesisIn: Current Opinion in Orthopaedics Vol. 17 (2006) pp. 405 - 411Online Full Text: dx.doi.org/
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Expression of Fgf and Tgfβ signaling related genes during embryonic endochondral ossificationIn: Gene Expression Patterns Vol. 6 (2005) Nr. 1, pp. 102 - 109Online Full Text: dx.doi.org/
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Gli3 has repressing and activating functions downstream of Ihh in regulating two distinct steps of chondrocyte differentiationIn: Development / Company of Biologists Vol. 132 (2005) Nr. 23, pp. 5249 - 5260Online Full Text: dx.doi.org/
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Essential role for ADAM19 in cardiovascular morphogenesisIn: Molecular and Cellular Biology (MCB) Vol. 24 (2004) Nr. 1, pp. 96 - 104Online Full Text: dx.doi.org/
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Ext1 dependent heparan sulfates regulate the range of Ihh signaling during endochondral ossificationIn: Developmental Cell Vol. 6 (2004) pp. 801 - 813Online Full Text: dx.doi.org/ (Open Access)
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Model systems for human muscoskeletal diseasesIn: Drug Discovery Today: Disease Models Vol. 1 (2004) Nr. 3, pp. 359 - 364Online Full Text: dx.doi.org/
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Targeted expression of SHH affects chondrocyte differentiation, growth plate organization, and Sox9 expressionIn: Journal of Bone and Mineral Research (JBMR) Vol. 19 (2004) pp. 1678 - 1688
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Expression of Trps1 during mouse embryonic development.In: (Mech Dev) Vol. 119 Suppl 1 (2002) pp. 117 - 120
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Interaction of FGF, Ihh/Pthlh and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation.In: (Dev Cell) Vol. 3 (2002) pp. 439 - 449
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Role of Runx genes in chondrocyte differentiation.In: (Dev Biol) Vol. 245 (2002) pp. 95 - 108
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BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation.In: Development Vol. 128 (2001) pp. 4523 - 4534
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Interaction of growth factors regulating chondrocyte differentiation in the developing embryo.In: Osteoarthritis and Cartilage Vol. 9 (2001) pp. 109 - 117
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Sex-specific expression of an evolutionarily conserved male regulatory gene, DMRT1, in birds.In: Cytogenetics and Cell Genetics Vol. 89 (2000) Nr. 3-4, pp. 252 - 257
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Interaction of Ihh and BMP/Noggin signaling during cartilage differentiation.In: (Dev Biol) Vol. 209 (1999) pp. 239 - 253
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Recapitulation of signals regulating embryonic bone formation during postnatal growth and in fracture repair.In: (Mech Dev) Vol. 71 (1998) pp. 65 - 76
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Defining the skeletal elements.In: (Curr Biol) Vol. 7 (1997) pp. 104 - 107
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Point mutations in human GLI3 cause Greig syndrome.In: (Hum Mol Genet) Vol. 6 (1997) pp. 1979 - 1984
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PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth.In: Science Vol. 273 (1996) pp. 663 - 666
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Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein.In: Science Vol. 273 (1996) pp. 613 - 622
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Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development.In: (Dev Biol) Vol. 180 (1996) pp. 273 - 283
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The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse.In: (J Immunol) Vol. 156 (1996) pp. 585 - 592
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Identification of optimized target sequences for the GLI3 zinc finger protein.In: (DNA Cell Biol) Vol. 14 (1995) pp. 629 - 634
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Isolation and characterization of a cosmid contig for the GCPS gene region.In: (Hum Genet) Vol. 95 (1995) pp. 82 - 88
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Isolation of a yeast artificial chromosome contig spanning the Greig cephalopolysyndactyly syndrome (GCPS) gene region.In: (Genomics) Vol. 22 (1994) pp. 563 - 568
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Molecular linkage of the morphogenetic mutation add and the zinc finger gene Gli3.In: (Mamm Genome) Vol. 4 (1993) pp. 276 - 277
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Deletion of GLI3 supports the homology of the human Greig cephalopolysyndactyly syndrome (GCPS) and the mouse mutant extra toes (Xt).In: (Mamm Genome) Vol. 3 (1992) pp. 461 - 463
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Expression of the zinc finger gene Gli3 is affected in the morphogenetic mouse mutant extra-toes (Xt).In: Development Vol. 116 (1992) pp. 799 - 804
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A somatic cell hybrid panel and DNA probes for physical mapping of human chromosome 7p.In: Genomics Vol. 11 (1991) Nr. 3, pp. 737 - 743
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GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families.In: Nature Vol. 352 (1991) Nr. 8. August, pp. 535 - 540