CRC 1093 - Principal Investigator Matthias Epple
Project Area A A5: Protein-specific nanoparticles for cellular uptake
Since supramolecular ligands as well as certain proteins must ultimately be transported into cells, we will exploit large multishell CaP nanoparticles (100 nm) as transport vehicles across cell membranes. The pathway of the labeled cargo into and inside the cell can be monitored by confocal fluorescence microscopy. On the other hand, very small Au or SiO2 nanoparticles (2-5 nm) will be equipped with specific protein-binding peptides and receptor molecules provided by other partners from the CRC, which render the functionalized nanoparticles specific for central pores, flanks or interfaces of self-assembled protein machines.
Read moreCurriculum Vitae
Professional career
| 2003-today | Full Professor (C4) of Inorganic Chemistry, University of Duisburg-Essen |
| 2000-2003 | Associate Professor (C3) of Inorganic Chemistry, University of Bochum |
| 1998 | Substituting Professor (Solid State Chemistry), University of Augsburg |
| 1993 | Postdoctoral Research Assistant with Prof. Dr. J.C. Berg, University of Washington, USA |
Scientific education and degrees
| 1997 | Habilitation and Venia legendi (Solid State Chemistry) at the University of Hamburg, Mentor: Prof. Dr. A. Reller |
| 1989-1992 | Ph.D. at the Technical University of Braunschweig with Prof. Dr. H.K. Cammenga |
| 1984-1989 | Study of Chemistry (Dipl.) at the Technical University of Braunschweig, Diploma thesis with Prof. Dr. H.K. Cammenga |
Selected Publications
J. Helmlinger, C. Sengstock, C. Groß-Heitfeld, C. Mayer, T.A. Schildhauer, M. Köller, M. Epple: "Silver nanoparticles with different size and shape: Equal cytotoxicity, but different antibacterial effect", RSC Adv. 2016, 6, 18490-18501.
J. Helmlinger, O. Prymak, K. Loza, M. Gocyla, M. Heggen, M. Epple: "On the crystallography of silver nanoparticles with different shapes", Cryst. Growth & Design 2016, 16, 3677-3687.
K. Loza, I. Schremmer, J. Bünger, G.A. Westphal, M. Köller, M. Epple, C. Sengstock: "Barium sulfate micro- and nanoparticles as bioinert reference material in particle toxicology", Nanotoxicology 2016, 10, 1492-1502.
K. Haedicke, D. Kozlova, S. Gräfe, U. Teichgräber, M. Epple, I. Hilger: "Multi-functional calcium phosphate nanoparticles for combining near-infrared fluorescence optical imaging and photodynamic therapy", Acta Biomater. 2015, 14, 197-207.
S. Ristig, O. Prymak, K. Loza, M. Gocyla, W. Meyer-Zaika, M. Heggen, D. Raabe, M. Epple: "Nanostructure of wet-chemically prepared, polymer-stabilized silver-gold nanoalloys over the entire composition range", J. Mater. Chem. B 2015, 3, 4654-4662.
B. Neuhaus, A. Frede, A.M. Westendorf, M. Epple: "Gene silencing of the pro-inflammatory cytokine TNF-α with calcium phosphate nanoparticles", J. Mater. Chem. B 2015, 3, 7186-7193.
S. Banerjee, K. Loza, W. Meyer-Zaika, O. Prymak, M. Epple: Structural evolution of silver nanoparticles during wet-chemical synthesis. Chem. Mater. 2014, 26, 951-957.
J. Enax, O. Prymak, D. Raabe, M. Epple: Structure, composition, and mechanical properties of shark teeth. J. Struct. Biol. 2012, 178, 290-299.
D. Kozlova, S. Chernousova, T. Knuschke, J. Buer, A. M. Westendorf, M. Epple: Cell targeting by antibody-functionalized calcium phosphate nanoparticles. J. Mater. Chem. 2012, 22, 396-404.
S. Kittler, C. Greulich, J. Diendorf, M. Köller, M. Epple: Toxicity of silver nanoparticles increases during storage because of slow dissolution under release of silver ions. Chem. Mater. 2010, 22, 4548-45.
