2017

W. Pfeifer, P. Lill, C. Gatsogiannis, B. Saccà: Hierarchical Assembly of DNA Filaments with Designer Elastic Properties. ACS Nano. 2017 Nov 21. doi: 10.1021/acsnano.7b06012.

D. Bier, S. Mittal, K. Bravo-Rodriguez, A. Sowislok, X. Guillory, J. Briels, C. Heid, M. Bartel, B. Wettig, L. Brunsveld, E. Sanchez-Garcia, T. Schrader, C. Ottmann: The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface. J Am Chem Soc. 2017 Nov 15;139(45):16256-16263. doi: 10.1021/jacs.7b07939. Epub 2017 Nov 2.

J. Wissler, M. Wehmeyer, S. Bäcker, S. Knauer , S. Schlücker : Simultaneous Rayleigh/Mie and Raman/Fluorescence Characterization of Molecularly Functionalized Colloids by Correlative Single-Particle Real-Time Imaging in Suspension. Anal Chem. 2017 Nov 7. doi: 10.1021/acs.analchem.7b02528.

A. Hogeweg , A. Sowislok , T. Schrader, C. Beuck : An NMR Method To Pinpoint Supramolecular Ligand Binding to Basic Residues on Proteins. Angew Chem Int Ed Engl. 2017 Nov 13;56(46):14758-14762. doi: 10.1002/anie.201707950. Epub 2017 Oct 13.

J. Wissler, S. Bäcker, A. Feis, S. Knauer , S. Schlücker : Site-Specific SERS Assay for Survivin Protein Dimer: From Ensemble Experiments to Correlative Single-Particle Imaging. Small. 2017 July 4. doi: 10.1002/smll.201700802

A. Scheer, S. Knauer, R. Verhaegh: Survivin expression pattern in the intestine of normoxic and ischemic rats. BMC Gastroenterology 2017 Jun. 14. DOI: 10.1186/s12876-017-0625-6

S. Riebe, C. Vallet, F. van der Vight, D. Gonzalez-Abradelo, C. Wölper, C. A. Strassert, G. Jansen, S. Knauer, J. Voskuhl: Aromatic Thioethers as novel Luminophores with Aggregation‐ Induced Fluorescence and Phosphorescence. Chem. Eur. J. 2017 Jun 29. doi: 10.1002/chem.201701867

P. de Vink, J. Briels, T. Schrader, L. Milroy, L. Brunsveld, C. Ottmann: Cucurbit[8]uril and 14-3-3 based binary bivalent supramolecular-protein assembly platform and co-crystal structure. Angew Chem Int Ed Engl. 2017 May 16. doi: 10.1002/anie.201701807

M. Kopp , S. Kollenda, M. Epple: Nanoparticle-protein interactions: Therapeutic approaches and supramolecular chemistry. Acc. Chem. Res. 2017, 50 (6), pp 1383–1390, doi: 10.1021/acs.accounts.7b00051

T. Vöpel, K. Bravo-Rodriguez, S. Mittal, S. Vachharajani, D. Gnutt, A. Sharma, A. Steinhof, O. Fatoba, G. Ellrichmann, M. Nshanian, C. Heid, J. A. Loo, F. G. Klärner, T. Schrader, G. Bitan, E. E. Wanker, S. Ebbinghaus E. Sanchez-Garcia: Inhibition of Huntingtin Exon-1 Aggregation by the Molecular Tweezer CLR01. J. Am. Chem. Soc. 2017 Apr 26;139(16):5640-5643. doi: 10.1021/jacs.6b11039. Epub 2017 Apr 13

P. Gilles, K. Wenck, I. Stratmann, M. Kirsch , D. A. Smolin, T. Schaller, H. de Groot, A. Kraft, T. Schrader: High-Affinity Copolymers Inhibit Digestive Enzymes by Surface Recognition. Biomacromolecules. 2017 Jun 12;18(6):1772-1784. doi: 10.1021/acs.biomac.7b00162. Epub 2017 May 9

S. Koecher, J. Rey, J. Bongard, A. N. Tiaden, M. Meltzer, P. Richards, M. Ehrmann, M. Kaiser: Tailored Ahp-cyclodepsipeptides as potent non-covalent serine protease inhibitors. Angew. Chem. Int. Ed. 2017 May 17. doi: 10.1002/anie.201701771

E.-C. Schöneweiß, B. Saccà: The collective behavior of spring-like motifs tethered to a DNA origami nanostructure. Nanoscale. 2017, 9, 4486

C. Wilch, P. Talbiersky, U. Berchner-Pfannschmidt, T. Schaller, M. Kirsch , F.-G. Klärner, T. Schrader: Molecular tweezers inhibit PARP-1 by a new Mechanism. Eur. J. Org. Chem. 2017. DOI: 10.1002/ejoc.201601596 - very important paper.

M. Kopp, O. Rotan, C. Papadopoulos, N. Schulze, H. Meyer, M. Epple: Delivery of the autofluorescent protein R-phycoerythrin by calcium phosphate nanoparticles into four different eukaryotic cell lines (HeLa, HEK293T, MG-63, MC3T3): Highly efficient, but leading to endolysosomal proteolysis in HeLa and MC3T3 cells. PLOS ONE 2017, June 6, https://doi.org/10.1371/journal.pone.0178260

P. Jana, K. Samanta, S. Bäcker, E. Zellermann, S. Knauer C. Schmuck: Efficient Gene Transfection through Inhibition of β-Sheet (Amyloid Fiber) Formation of a Short Amphiphilic Peptide by Gold Nanoparticles. Angew Chem Int Ed Engl. 2017, Apr 10. doi: 10.1002/anie.201700713

S. Chernousova , M. Epple: Live-cell imaging to compare the transfection and gene silencing efficiency of calcium phosphate nanoparticles and a liposomal transfection agent. Gene Therapy. 2017, 24, 282–289; doi:10.1038/gt.2017.13

A. Sprengel, P. Lill, P. Stegemann, K. Bravo-Rodriguez, E.-C. Schöneweiß, M. Merdanovic, D. Gudnason, M. Aznauryan, L. Gamrad, S. Barcikowski, E. Sanchez-Garcia , V. Birkedal, C. Gatsogiannis, M. Ehrmann , B. Saccà: Tailored protein encapsulation into a DNA host using geometrically organized supramolecular interactions. Nat. Comm. 2017. doi: 10.1038/ncomms14472

A. C. Faesen, M. Thanasoula, S. Maffini, C. Breit, F. Müller, S. van Gerwen, T. Bange, A. Musacchio: Basis of catalytic assembly of the mitotic checkpoint complex. Nature. 2017, Feb 23; 542, 498–502.

C. Gerke, M. F. Ebbesen, D. Jansen, S. Boden, T. Freichel, L. Hartmann: Sequence-controlled glycopolymers via step-growth polymerization of precision glycomacromolecules for lectin receptor clustering. Biomacromolecules. 2017, DOI: 10.1021/acs.biomac.6b01657

O. Rotan, K. N. Severin, S. Pöpsel, A. Peetsch, M. Merdanovic, M. Ehrmann, M. Epple: Uptake of the proteins HTRA1 and HTRA2 by cells mediated by calcium phosphate nanoparticles. Beilstein J. Nanotechn. 2017, 8, 381–393.

D. Pan, K. Klare, A. Petrovic, A. Take, K. Walstein, P. Singh, A. Rondelet, A. W. Bird, A. Musacchio: CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading. Elife. 2017, Jan 6; 6. pii: e23352. doi: 10.7554/eLife.23352.

M. Nemec, D. Hoffmann: Quantitative assessment of molecular dynamics sampling for flexible systems. J Chem Theory Comput. 2017 Jan 13. doi: 10.1021/acs.jctc.6b00823.

C. Papadopoulos, P. Kirchner, M. Bug, D. Grum, L. Koerver, N. Schulze, R. Poehler, A. Dressler, S. Fengler, K. Arhzaouy, V. Lux, M. Ehrmann, C. C. Weihl , H. Meyer: VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy. EMBO J. 2017, 36:135-150

2016

P. J. Huis In 't Veld, S. Jeganathan, A. Petrovic, P. Singh, J. John, V. Krenn, F. Weissmann, T. Bange, A. Musacchio: Molecular basis of outer kinetochore assembly on CENP-T. Elife. 2016 , Dec 24; 5. pii: e21007.

P. Jana, M. Ehlers, E. Zellermann, K. Samanta, C. Schmuck: pH-Controlled Formation of a Stable ß-Sheet and Amyloid-like Fibers from an Amphiphilic Peptide: The Importance of a Tailor-Made Binding Motif for Secondary Structure Formation. Angew Chem Int Ed Engl. 2016 Dec 5;55(49):15287-15291.

D. Bier, M. Bartel, K. Sies, S. Halbach, Y. Higuchi, Y. Haranosono, T. Brummer, N. Kato, C. Ottmann: Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface. Chem. Med. Chem. 2016, 11, 911-8.

A. Petrovic, J. Keller, Y. Liu, K. Overlack, J. John, Y. Dimitrova, S. Jenni, S. van Gerwen, P. Stege, S. Wohlgemuth,P. Rombaut, F. Herzog, S.C. Harrison, I. Vetter, A. Musacchio: Structure of the MIS12 complex and molecular basis of its interaction with CENP-C at human kinetochores. Cell 2016 167:1020-1040. http://dx.doi.org/10.1016/j.cell.2016.10.005

F. Trusch, K. Kowski, K. Bravo-Rodriguez, C. Beuck, A. Sowislok, B. Wettig, A. Matena, E. Sanchez-Garcia, H. Meyer, T. Schrader, P. Bayer: Molecular tweezers target a protein-protein interface and thereby modulate complex formation. Chem Commun 2016 (Camb). Nov 21. [Epub ahead of print]

J. van den Boom, M. Wolf, L. Weimann, N. Schulze, F. Li, F. Kaschani, A. Riemer, C. Zierhut, M. Kaiser, G. Iliakis, H. Funabiki, H. Meyer: VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair. Molecular Cell 2016 64, 189–198 October 6.

D. Maity, C. Schmuck: Fluorescent Peptide Beacons for the Selective Ratiometric Detection of Heparin. Chemistry 2016 Sep 5;22(37):13156-61. doi: 10.1002/chem.201602240. Epub 2016 Aug 18.

J.R. Weir, A.C. Faesen, K. Klare, A. Petrovic, F. Basilico, J. Fischböck, S. Pentakota, J. Keller, M.E. Pesenti, D. Pan, D. Vogt, S. Wohlgemuth, F. Herzog, A. Musacchio: Insights from biochemical reconstitution into the architecture of human kinetochores. Nature. 2016 Aug 31;537(7619):249-253. doi: 10.1038/nature19333. Epub ahead of print

C. Schmuck, K. Samanta, M. Ehlers: Two-Component Self-Assembly: Hierarchical Formation of pH-Switchable Supramolecular Networks by pi-pi Induced Aggregation of Ion Pairs. Chemistry 2016 Aug 30. doi: 10.1002/chem.201603944. Epub ahead of print.

T. Schrader, G. Bitan and F. G. Klärner: Molecular tweezers for lysine and arginine - powerful inhibitors of pathologic protein aggregation. Chem Commun(Camb). 2016 Aug 22. Epub ahead of print.

C. Streich, L. Akkari, C. Decker, J. Bormann, C. Rehbock, A. Müller-Schiffmann, F. C. Niemeyer, L. Nagel-Steger, D. Willbold, B. Sacca, C. Korth, T. Schrader, S. Barcikowski: Characterizing the Effect of Multivalent Conjugates Composed of Aβ-Specific Ligands and Metal Nanoparticles on Neurotoxic Fibrillar Aggregation. ACS Nano.2016 Aug 23;10(8):7582-97. doi: 10.1021/acsnano.6b02627. Epub 2016 Jul 20.

A. Friese, A.C. Faesen, P. J. Huis In 't Veld, J. Fischböck, D. Prumbaum, A. Petrovic, S. Raunser, F. Herzog, A. Musacchio: Molecular requirements for the inter-subunit interaction and kinetochore recruitment of SKAP and Astrin. Nat Commun. 2016 7:11407. doi: 10.1038/ncomms11407.

P. Jana, C. Schmuck: Self-Assembly of a Tripodal Triszwitterion Forms a pH-Switchable Hydrogel that Can Reversibly Encapsulate Hydrophobic Guests in Water. Chemistry 2016 Jul 20. doi: 10.1002/chem.201601122. Epub ahead of print.

H. Frisch, D. Spitzer, J. Voskuhl*, P. Besenius*: Probing the Self-Assembly and Stability of Oligohistidine based Rod-like Micelles by Aggregation Induced Luminescence. Org. Biomol. Chem. 2016, Jun 15;14(24):5574-9. *corresponding authors

B. Schmidt, S. Sankaran, L. Stegemann, C. A. Strassert, P. Jonkheijm*, J. Voskuhl*: Agglutination of Bacteria Using Polyvalent Nanoparticles of Aggregation-induced Emissive Thiophthalonitrile Dyes. J. Mater. Chem. B. 2016, Jun 13; 4, 4732-4738. *corresponding authors

W. Pfeifer, B. Saccà: From Nano to Macro through Hierarchical Self-Assembly: The DNA Paradigm. Chembiochem. 2016 Jun 16;17(12):1063-80. doi: 10.1002/cbic.201600034. Epub 2016 May 17. Review.

D. Maity, J. Jiang, M. Ehlers, J. Wu, C. Schmuck: A FRET-enabled molecular peptide beacon with a significant red shift for the ratiometric detection of nucleic acids. Chem Commun (Camb). 2016 May 4;52(36):6134-7. doi: 10.1039/c6cc02138g. Epub 2016 Apr 13. PMID: 27071707

J. van den Boom, F. Trusch, L. Hoppstock, C. Beuck, P. Bayer: Structural Characterization of the Loop at the Alpha-Subunit C-Terminus of the Mixed Lineage Leukemia Protein Activating Protease Taspase1. PLoS One. 2016 Mar 14;11(3):e0151431. doi: 10.1371/journal.pone.0151431. eCollection 2016.

L.M. Stevers, C.V. Lam, S.F.Leysen, F.A. Meijer, D.S. van Scheppingen, R.M. de Vries, G.W. Carlile, L.G. Milroy, D.Y. Thomas, L. Brunsveld, C. Ottmann: Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR. Proc Natl Acad Sci U S A 2016 Mar 1;113(9):E1152-61. doi: 10.1073/pnas.1516631113. Epub 2016 Feb 17.

B. Schuetze, C. Mayer, K. Loza, M. Gocyla, M. Heggen, M. Epple: The conjugation of thiol-terminated molecules to ultrasmall 2 nm-gold nanoparticles leads to remarkably complex 1H-NMR spectra. Journal of Materials Chemistry B. 2016, 4, 2179-2189.

H.F. Bettinger, C. Tönshoff, M. Doerr, E. Sanchez-Garcia: Electronically Excited States of Higher Acenes up to Nonacene: A Density Functional Theory/Multireference Configuration Interaction (DFT/MRCI) Study J Chem Theory Comput. 2016 Jan 12;12(1):305-12

M. Li, M. Ehlers, S. Schlesiger, E. Zellermann, S. K. Knauer, C. Schmuck: Incorporation of a Non-Natural Arginine Analogue into a Cyclic Peptide Leads to Formation of Positively Charged Nanofibers Capable of Gene Transfection. Angew Chem Int Ed Engl 2016, Jan 11;55(2):598-601. doi: 10.1002/anie.201508714. Epub 2015 Nov 27.

B. Unruhe, E. Schröder, D. Wünsche, S. K. Knauer: An Old Flame Never Dies: Survivin in Cancer and Cellular Senescence. Gerontology. 2016; 62(2):173-81. doi: 10.1159/000432398. Epub 2015 Jul 3. PMID: 26159786

2015

D. Bier, M. Bartel, K. Sies, S. Halbach, Y. Higuchi, Y. Haranosono, T. Brummer, N. Kato, C. Ottmann: Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface. Chem. Med. Chem. 2015 Dec 8. doi: 10.1002/cmdc.201500484.

M. Skwarczynska, C. Ottmann: Protein-protein interactions as drug targets. Future Med. Chem.. 2015, 7, 2195-219.

R. Meyer, B. Saccà, C.M. Niemeyer: Site-directed, on-surface assembly of DNA nanostructures. Angew Chem Int Ed Engl. 2015 Oct 5;54(41):12039-43. doi: 10.1002/anie.201505553.

V. Krenn, A. Musacchio: The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling. Front Oncol. 2015, 5:225. doi: 10.3389/fonc.2015.00225.

M. Ehrmann, F. Kaschani , M. Kaiser: Chemical proteomics versus Leishmaniasis. Chem. Biol. 2015, 22:309-310

K. Althoff, S. Lindner, A. Odersky, P. Mestdagh, S. Tillmann, J. Molenaar, S. Knauer, F. Speleman, M. Epple, D. Kozlova, S. Yoon, K. Baek, J. Vandesompele, A. Eggert, A. Schramm, J.H. Schulte: miR-542-3p exerts tumor suppressive functions in neuro-blastoma by downregulating survivin. International Journal of Cancer 136, 2015, 1308-1320.

L.G. Milroy, M. Bartel, M.A. Henen, S. Leysen, J.M. Adriaans, L. Brunsveld, I. Landrieu, C. Ottmann: Stabilizer-Guided Inhibition of Protein-Protein Interactions. Angew. Chem. Int. Ed. 2015 Nov 5. doi: 10.1002/anie.201507976.

F. Trusch, A. Matena, M. Vuk, L. Koerver, H. Knævelsrud, P. S. Freemont, H. Meyer, P. Bayer: The N-terminal Region of the UBX Domain-containing Protein 1 (UBXD1) Modulates Interdomain Communication within the Valosin-containing Protein p97. J. Biol. Chem. 2015, Oct 16. pii: jbc.M115.680686.

Y. Zhang, B. Walkenfort, J. H. Yoon, S. Schlücker, W. Xie: Gold and silver nanoparticle monomers are non-SERS-active: a negative experimental study with silica-encapsulated Raman-reporter-coated metal colloids. PCCP 2015, 17, 21120-21126

M. Schütz, S. Schlücker : Molecularly Linked 3D Plasmonic Nanoparticle Core/Satellite Assemblies: SERS Nanotags with Single-Particle Raman Sensitivity. PCCP 2015, 17, 24356-24360.

N. J. Thompson, M. Merdanovic, M. Ehrmann, E. van Duijn, A. J. R. Heck: Substrate Occupancy at the Onset of Oligomeric Transitions of DegP. Structure 2015, 22: 281–290

A. Musacchio: The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics. Curr Biol. 2015, 25:R1002-18. doi: 10.1016/j.cub.2015.08.051.

G. Herzog, L. Engel, M. D. Shmueli, E. Gazit, F. G. Klärner, T. Schrader, G. Bitan, and D. Segal: The Lys-specific molecular tweezer, CLR01, inhibits the late stages of p53 DNA binding domain aggregation and toxicity. Biochemistry 2015, 54, 3729–3738.

S. Poepsel, A. Sprengel, B. Sacca, F. Kaschani , M. Kaiser, C. Gatsogiannis, S. Raunser, T. Clausen and M. Ehrmann: Determinants of amyloid fibril degradation by the PDZ protease HTRA1. Nature Chemical Biology. 2015, doi:10.1038/nchembio.1931. Comment

X. Zheng, D.-Y. Liu, F.G. Klärner, T. Schrader, G. Bitan and M.T. Bowers: Amyloid β-protein Assembly: The Effect of Molecular Tweezer CLR01 and CLR03. J. Phys. Chem. B 2015, 119, 4831-4841.

E. Lump, L. M. Castellano, C. Meier, J. Seeliger, N. Erwin, B. Sperlich, C. M. Stürzel, S. Usmani, R. M. Hammond, J. von Einem, G. Gerold, F. Kreppel, K. Bravo-Rodriguez, T. Pietschmann, V. M. Holmes, D. Palesch, O. Zirafi, D. Weissman, A. Sowislok, B. Wettig, C. Heid, F. Kirchhoff, T. Weil, F.-G. Klärner, T. Schrader, G. Bitan, E. Sanchez-Garcia, R. Winter, J. Shorter, J. Münch: Molecular Tweezers Inhibit Islet Amyloid Polypeptide Assembly and Toxicity by a New Mechanism. eLife. 2015; 4:e05397. DOI: 10.7554/eLife.05397

D. Bier, P. Thiel, J. Briels, C. Ottmann: Stabilization of Protein-Protein Interactions in chemical biology and drug discovery. Prog Biophys Mol Biol. 2015, Jun 18. pii: S0079-6107(15)00073-5

P. Sokkar, E. Boulanger, W. Thiel, E. Sanchez-Garcia: Hybrid Quantum Mechanics/Molecular Mechanics/Coarse-Grained Modeling: A Triple-Resolution Approach for Biomolecular Systems”. Journal of Chemical Theory and Computation. 2015 DOI: 10.1021/ct500956u (Journal Cover)

D.H. Lopes, A. Attar, G. Nair, E.Y. Hayden, Z. Du, K. McDaniel, S. Dutt, K. Bravo-Rodriguez, .S Mittal, F.G. Klärner, C. Wang, E. Sanchez-Garcia, T. Schrader, G. Bitan: Molecular Tweezers Inhibit Islet Amyloid Polypeptide Assembly and Toxicity by a New Mechanism. ACS Chem Biol . 2015 Apr 16.

K. Haedicke, D. Kozlova, S. Gräfe, U. Teichgräber, M. Epple*, I. Hilger*: Multi-functional calcium phosphate nanoparticles for combining near-infrared fluorescence optical imaging and photodynamic therapy Acta Biomaterialia. 2015, 14, 197-207.*corresponding author

A. Altenfeld, S. Wohlgemuth, A. Wehenkel, I.R. Vetter, A. Musacchio: Complex assembly, crystallization and preliminary X-ray crystallographic analysis of the human Rod-Zwilch-ZW10 (RZZ) complex. Acta Crystallogr F Struct Biol Commun. 2015 Apr;71(Pt 4):438-42. doi: 10.1107/S2053230X15004343. Epub 2015 Mar 20.

B. Saccà, Y. Ishitsuka, R. Meyer, A. Sprengel, E.C. Schöneweiß, G.U. Nienhaus, C.M. Niemeyer: Reversible Reconfiguration of DNA Origami Nanochambers Monitored by Single-Molecule FRET. Angew Chem Int Ed Engl. , 2015 Jan 28.

M. Li, S. Schlesiger, S. K. Knauer, C. Schmuck: A Tailor-Made Specific Anion-Binding Motif in the Side Chain Transforms a Tetrapeptide into an Efficient Vector for Gene Delivery. Angew Chem Int Ed Engl . 2015, Jan 22.

2014

A. Eiteneuer, J. Seiler, M. Weith, M. Beullens, B. Lesage, V. Krenn, A. Musacchio, M. Bollen, H. Meyer: Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 to kinetochore-bound protein phosphatase-1. EMBO J.. 2014, Nov 18;33(22):2704-20.

M. Klammer, J.N. Dybowski, D. Hoffmann, C. Schaab: Identification of significant features by the global mean rank test. PLoS One. 2014 9(8):e104504.

F. Giordanetto, A. Schäfer C. Ottmann: Stabilization of protein-protein interactions by small molecules. Drug. Discov. Today. 2014, 19, 1812-21.

J. van den Boom, M. Mamić, D. Baccelliere, S. Zweerink, F. Kaschani, S. Knauer, P. Bayer M. Kaiser: Peptidyl succinimidyl peptides as taspase 1 inhibitors. Chembiochem. 2014,Oct 13;15(15):2233-7.

R. Rebollido-Rios, S. Bandari, C. Wilms, S. Jakuschev, A. Vortkamp, K. Grobe, D. Hoffmann: Signaling Domain of Sonic Hedgehog as Cannibalistic Calcium-Regulated Zinc-Peptidase. PLoS Comput Biol. 2014 07;10(7):e1003707.

G. Dördelmann, D. Kozlova, S. Karczewski, R. Lizio, S. Knauer, M. Epple: Calcium phosphate increases the encapsulation efficiency of hydrophilic drugs (proteins, nucleic acids) into poly (D,L-lactide-co-glycolide acid) nanoparticles for intracellular delivery. Journal of Materials Chemistry B. 2014, 2, 7250-7259

B. Saccà: Nucleic acids nanotechnology Methods. 2014, May 15;67(2):103-4. doi: 10.1016/j.ymeth.2014.04.018.

C. Meesters, T. Mönig, J. Oeljeklaus, D. Krahn, C. S. Westfall, B. Hause, J. M. Jez, M. Kaiser, E. Kombrink: A chemical inhibitor of jasmonate signaling targets JAR1 in Arabidopsis thaliana. Nat Chem Biol. 2014 Aug 17.

A. Riemer, G. Dobrynin, A. Dressler, S. Bremer, A. Soni, G. Iliakis, H. Meyer: The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradation. Cell Cycle 2014 13:919-27.

L.G. Milroy, T.N. Grossmann, S. Hennig, L. Brunsveld,C. Ottmann: Modulators of protein-protein interactions. Chemical Reviews 2014, 114, 4695-748.

D. Heider, J. N. Dybowski, C. Wilms, D. Hoffmann: A simple structure-based model for the prediction of HIV-1 co-receptor tropism. BioData Min. 2014 Aug 1;7:14. doi: 10.1186/1756-0381-7-14. eCollection 2014.

P. Latza, P. Gilles, T. Schaller, T. Schrader: Affinity Polymers Tailored for the Protein A Binding Site of Immunoglobulin G Proteins. Chem. Eur. J. 2014, 11479-11487.

K. Bravo-Rodriguez, Kenny, A. F. Ismail-Ali, S. Klopries, S. Kushnir, S. Ismail, E. K. Fansa, A. Wittinghofer, F. Schulz and E. Sanchez-Garcia: Predicted Incorporation of Non-Native Substrates by a Polyketide Synthase Yields Bioactive Natural Product Derivatives. Chembiochem. 2014 15, 1991–1997.

A. Attar, W.-T. Coco Chan, F.G. Klärner, T. Schrader, G. Bitan: Safety and pharmacological characterization of the molecular tweezer CLR01 – a broad-spectrum inhibitor of amyloid proteins’ toxicity. BMC Pharmacology and Toxicology 2014, 15:23

M. Bartel, A. Schäfer, L.M. Stevers, C. Ottmann: Small molecules, peptides and natural products: getting a grip on 14-3-3 protein-protein modulation. Future Med. Chem. 2014, 6, 903-21.

M. Scheepstra, L. Nieto, A.K.H. Hirsch, S. Fuchs, S. Leysen, C.V. Lam, S. van Boeckel, H. Wienk, R. Boelens, C. Ottmann, L.M. Milroy, L. Brunsveld: A natural-product switch for a dynamic protein interface. Angew. Chem. Int. Ed. 2014, 53, 6443-8.

N. Ferreira, A. Pereira-Henriques, A. Attar, F.-G. Klärner, T. Schrader, G. Bitan, M. J. Saraiva, M. R. Almeida: Molecular Basis for Preventing α-Synuclein Aggregation by a Molecular Tweezer. Neurotherapeutics 2014, 11, 450-461.

A. Glas, D. Bier, G. Hahne, C. Rademacher,C. Ottmann, T.N. Grossmann: Constrained Peptides with Target-Adapted Cross-Links as Inhibitors of a Pathogenic Protein-Protein Interaction. Angew. Chem. Int. Ed., 2014, 53, 2489-93.

S. Acharya, B. M. Safaie, P. Wongkongkathep, M. I. Ivanova, A. Attar, F.-G. Klärner, T. Schrader, J. A. Loo, G. Bitan, L. J. Lapidus: Molecular Basis for Preventing α-Synuclein Aggregation by a Molecular Tweezer. J. Biol. Chem. 2014, 289, 10727-10737.