For Students

Dear students (medicine and life sciences)

Are you looking for an exciting topic for a medical doctoral thesis, Bachelor's or Master's thesis in life sciences? We offer experimental projects to elucidate pathomechanisms in sepsis and severe injuries. The focus is on the effects on the innate immune system and the identification of potential therapeutic targets. Through close cooperation with various clinics, we have access to patient samples for our studies. In addition, appropriate in vivo and in vitro models are also used.

We offer comprehensive training in experimental methods and supervision by experienced staff. We expect enthusiasm and curiosity for research into pathomechanisms, reliability and the ability to work in a team.

Due to the complexity of the experimental work, at least one semester off and additional time for data analysis and writing manuscripts are required for acceptance as a doctoral candidate. Funding via ELAN is supported.

We look forward to receiving your application.

First author publications of students for the Dr. med.

Title	Authors	Journal	Date
Major Surgical Trauma Impairs the Function of Natural Killer Cells but Does Not Affect Monocyte Cytokine Synthesis	Müller-Heck R.M., Bösken B., Michiels I., Dudda M., Jäger M., and Flohé S.B.	Life 12:13	2021
TLR4 transactivates CD8+ T lymphocytes upon acute sterile tissue injury	Wienhöfer, L., Marker, M., Antoni, A. C., Sutter, K., Sander, A., Dudda, M., Flohé, S. B.	Immunohorizons 5 :298	2021
An inverse relationship between c-kit/CD117 and mTOR confers NK cell dysregulation late after severe injury	Bösken B., Hepner-Schefczyk M., Vonderhagen S., Dudda M., Flohé S. B.	Front Immunol 11:1200	2020
Circulating growth/differentiation factor 15 is associated with human CD56(bright) natural killer cell dysfunction and nosocomial infection in severe systemic inflammation.	Kleinertz, H., Hepner-Schefczyk, M., Ehnert, S., Claus, M., Halbgebauer, R., Boller, L., Huber-Lang, M., Cinelli, P., Kirschning, C., Flohé, S., Sander, A., Waydhas, C., Vonderhagen, S., Jäger, M., Dudda, M., Watzl, C., Flohé, S. B.	EBioMedicine 43:380.	2019
Human bone marrow mesenchymal stromal/stem cells acquire immunostimulatory properties upon cross-talk with natural killer cells and might improve the immune function of immunocompromised patients	Cui R., Rekasi H., Hepner-Schefczyk M., Fessmann K., Petri R.M., Bruderek K., Brandau S., Jäger M. Flohé S.B.	Stem Cell Res. Ther. 7:88.	2016

Prizes won by doctoral students

Price	Date
European New Investigator Award Competition (ENIAC) of the European Shock Society (van der Wurff)	2023
Doctoral Prize of the Faculty (Bösken)	2023
Poster Prize Research Day of the Faculty (Wedekind)	2023
Wilhelm-Roux Prize of the German Society for Orthopaedics and Trauma Surgery 2022 (Miteva)	2022
Poster Prize Research Day of the Faculty (Miteva)	2021
Poster Prize Research Day of the Faculty (van der Wurff)	2021
Doctoral Prize of the Faculty (Kleinertz)	2020

Prof. Dr. rer. nat. Stefanie Flohé

Experimental Trauma Surgery (head)
Immunology Sepsis/trauma (Group leader)