Publications

    Journal articles

  • Wang, Jun; Li, Qian; Qiu, Yuanwang; Kitanovski, Simo; Wang, Chen; Zhang, Chenxia; Li, Fahong; Li, Xiaoguang; Zhang, Zhenfeng; Huang, Lihua; Zhang, Jiming; Hoffmann, Daniel; Lu, Mengji; Lu, Hongzhou
    Cell-type-specific expression analysis of liver transcriptomics with clinical parameters to decipher the cause of intrahepatic inflammation in chronic hepatitis B
    In: iMeta Vol. 3 (2024) Nr. 4, e221
    Online Full Text: dx.doi.org/ (Open Access)
  • Schwarz, Tatjana; Ptok, Johannes; Damagnez, Maximilian; Menne, Christopher; Alizei, Elahe Salimi; Lang-Meli, Julia; Maas, Michelle; Habermann, Daniel; Hoffmann, Daniel; Schulze zur Wiesch, Julian; Lauer, Georg; Kefalakes, Helenie; Cornberg, Markus; Kraft, Anke RM.; Gliga, Smaranda; Bock, Hans H.; Horn, Peter A.; Maini, Mala K.; Thimme, Robert; Wedemeyer, Heiner; Nattermann, Jacob; Heinemann, Falko M.; Luedde, Tom; Neumann-Haefelin, Christoph; Walker, Andreas; Timm, Jörg
    HBV shows different levels of adaptation to HLA class I-associated selection pressure correlating with markers of replication
    In: Journal of Hepatology (2024) in press
    Online Full Text: dx.doi.org/ (Open Access)
  • Porfetye, Arthur T.; Stege, Patricia; Rebollido-Rios, Rocio; Hoffmann, Daniel; Schrader, Thomas; Vetter, Ingrid R.
    How Do Molecular Tweezers Bind to Proteins? : Lessons from X-ray Crystallography
    In: Molecules: A Journal of Synthetic Chemistry and Natural Product Chemistry Vol. 29 (2024) Nr. 8, 1764
    Online Full Text: dx.doi.org/ (Open Access)
  • Lei, Kuan Cheok; Srinivas, Nalini; Chandra, Mitalee; Kervarrec, Thibault; Coyaud, Etienne; Spassova, Ivelina; Peiffer, Lukas; Houben, Roland; Shuda, Masahiro; Hoffmann, Daniel; Schrama, David; Becker, Jürgen
    Merkel cell polyomavirus pan-T antigen knockdown reduces cancer cell stemness and promotes neural differentiation independent of RB1
    In: Journal of Medical Virology Vol. 96 (2024) Nr. 7, e29789
    Online Full Text: dx.doi.org/ (Open Access)
  • Tuz, Ali A.; Ghosh, Susmita; Karsch, Laura; Ttoouli, Dimitris; Sata, Sai P.; Ulusoy, Özgür; Kraus, Andreas; Hoerenbaum, Nils; Wolf, Jan-Niklas; Lohmann, Sabrina; Zwirnlein, Franziska; Kaygusuz, Viola; Lakovic, Vivian; Tummes, Hannah-Lea; Beer, Alexander; Gallert, Markus; Thiebes, Stephanie; Qefalia, Altea; Cibir, Zülal; Antler, Medina; Korste, Sebastian; Haj Yehia, Elias; Michel, Lars; Rassaf, Tienush; Kaltwasser, Britta; Abdelrahman, Hossam; Mohamud Yusuf, Ayan; Wang, Chen; Yin, Dongpei; Haeusler, Lars; Lueong, Smiths; Richter, Mathis; Engel, Daniel R.; Stenzel, Martin; Soehnlein, Oliver; Frank, Benedikt; Solo-Nomenjanahary, Mialitiana; Ho-Tin-Noé, Benoît; Siveke, Jens; Totzeck, Matthias; Hoffmann, Daniel; Grüneboom, Anika; Hagemann, Nina; Hasenberg, Anja; Desilles, Jean-Philippe; Mazighi, Mikael; Sickmann, Albert; Chen, Jianxu; Hermann, Dirk M.; Gunzer, Matthias; Singh, Vikramjeet
    Stroke and myocardial infarction induce neutrophil extracellular trap release disrupting lymphoid organ structure and immunoglobulin secretion
    In: Nature Cardiovascular Research Vol. 3 (2024) Nr. 5, pp. 525 - 540
    Online Full Text: dx.doi.org/ (Open Access)
  • Kitanovski, Simo; Cao, Yingying; Ttoouli, Dimitris; Farahpour, Farnoush; Wang, Jun; Hoffmann, Daniel
    scBubbletree: computational approach for visualization of single cell RNA-seq data
    In: BMC Bioinformatics Vol. 25 (2024) Nr. 1, 302
    Online Full Text: dx.doi.org/ (Open Access)
  • Waterkamp, Christoph; von Kortzfleisch, V T; Neu, Ch; Kitanovski, Simo; Richter, S H; Hoffmann, Daniel
    Increasing information gain in animal research by improving statistical model accuracy
    In: Journal of Physics: Conference Series (JPCONF) Vol. 2514 (2023) Nr. 1, 012021
    Online Full Text: dx.doi.org/ (Open Access)
  • Magvan, Battur; Kloeble, Anne Alina; Ptok, Johannes; Hoffmann, Daniel; Habermann, Daniel; Gantumur, Anuujin; Paluschinski, Martha; Enebish, Gerelmaa; Balz, Vera; Fischer, Johannes C.; Chimeddorj, Battogtokh; Walker, Andreas; Timm, Jörg
    Sequence diversity of hepatitis D virus in Mongolia
    In: Frontiers in Medicine Vol. 10 (2023) 1108543
    Online Full Text: dx.doi.org/ (Open Access)
  • Karakoese, Zehra; Le-Trilling, Vu Thuy Khanh; Schuhenn, Jonas; Francois, Sandra; Lu, Mengji; Liu, Jia; Trilling, Mirko; Hoffmann, Daniel; Dittmer, Ulf; Sutter, Kathrin
    Targeted mutations in IFNα2 improve its antiviral activity against various viruses
    In: mBio Vol. 14 (2023) Nr. 6, e02357-23
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Spassova, Ivelina; Ugurel, Selma; Kubat, Linda; Zimmer, Lisa; Terheyden, Patrick; Mohr, Annalena; Björn Andtback, Hannah; Villabona, Lisa; Leiter, Ulrike; Eigentler, Thomas; Loquai, Carmen; Hassel, Jessica C.; Gambichler, Thilo; Haferkamp, Sebastian; Mohr, Peter; Pfoehler, Claudia; Heinzerling, Lucie; Gutzmer, Ralf; Utikal, Jochen S.; Horny, Kai; Schildhaus, Hans-Ulrich; Habermann, Daniel; Hoffmann, Daniel; Schadendorf, Dirk; Becker, Jürgen
    Clinical and molecular characteristics associated with response to therapeutic PD-1/PD-L1 inhibition in advanced Merkel cell carcinoma
    In: Journal for ImmunoTherapy of Cancer Vol. 10 (2022) Nr. 1, e003198
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Rafieiolhosseini, Neda; Killa, Matthias; Neumann, Thorben; Tötsch, Niklas; Grad, Jean-Noël; Höing, Alexander; Dirksmeyer, Thies; Niemeyer, Jochen; Ottmann, Christian; Knauer, Shirley K; Giese, Michael; Voskuhl, Jens; Hoffmann, Daniel
    Computational model predicts protein binding sites of a luminescent ligand equipped with guanidiniocarbonyl-pyrrole groups
    In: Beilstein Journal of Organic Chemistry Vol. 18 (2022) pp. 1322 - 1331
    Online Full Text: dx.doi.org/ (Open Access)
  • Gravemeyer, Jan; Spassova, Ivelina; Verhaegen, Monique E.; Dlugosz, Andrzej A.; Hoffmann, Daniel; Lange, Anja; Becker, Jürgen
    DNA-methylation patterns imply a common cellular origin of virus- and UV-associated Merkel cell carcinoma
    In: Oncogene Vol. 41 (2022) Nr. 1, pp. 37 - 45
    Online Full Text: dx.doi.org/ (Open Access)
  • Streeck, Hendrik; Maestri, Alvino; Habermann, Daniel; Crowell, Trevor A.; Esber, Allahna L.; Son, Gowoon; Eller, Leigh Anne; Eller, Michael A.; Parikh, Ajay P.; Horn, Peter; Maganga, Lucas; Bahemana, Emmanuel; Adamu, Yakubu; Kiweewa, Francis; Maswai, Jonah; Owuoth, John; Robb, Merlin L.; Michael, Nelson L.; Polyak, Christina S.; Hoffmann, Daniel; Ake, Julie A.
    Dissecting drivers of immune activation in chronic HIV-1 infection
    In: EBioMedicine Vol. 83 (2022) 104182
    Online Full Text: dx.doi.org/ (Open Access)
  • Höing, Alexander; Struth, Robin; Beuck, Christine; Rafieiolhosseini, Neda; Hoffmann, Daniel; Stauber, Roland H.; Bayer, Peter; Niemeyer, Jochen; Knauer, Shirley
    Dual activity inhibition of threonine aspartase 1 by a single bisphosphate ligand
    In: RSC Advances Vol. 12 (2022) Nr. 53, pp. 34176 - 34184
    Online Full Text: dx.doi.org/ (Open Access)
  • Habermann, Daniel; Kharimzadeh, Hadi; Walker, Andreas; Li, Yang; Yang, Rongge; Kaiser, Rolf; Brumme, Zabrina L.; Timm, Jörg; Roggendorf, Michael; Hoffmann, Daniel
    HAMdetector : A Bayesian regression model that integrates information to detect HLA-associated mutations
    In: Bioinformatics Vol. 38 (2022) Nr. 9, pp. 2428 - 2436
    Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access)
  • Walker, Andreas; Schwarz, Tatjana; Brinkmann-Paulukat, Janine; Wisskirchen, Karin; Menne, Christopher; Alizei, Elahe Salimi; Kefalakes, Helenie; Theißen, Martin; Hoffmann, Daniel; Schulze zur Wiesch, Julian; Maini, Mala K.; Cornberg, Markus; Kraft, Anke RM; Keitel, Verena; Bock, Hans H.; Horn, Peter; Thimme, Robert; Wedemeyer, Heiner; Heinemann, Falko M.; Luedde, Tom; Neumann-Haefelin, Christoph; Protzer, Ulrike; Timm, Jörg
    Immune escape pathways from the HBV core₁₈₋₂₇ CD8 T cell response are driven by individual HLA class I alleles
    In: Frontiers in Immunology Vol. 13 (2022) 1045498
    Online Full Text: dx.doi.org/ (Open Access)
  • Reinold, Johanna; Farahpour, Farnoush; Fehring, Christian; Dolff, Sebastian; Konik, Margarethe; Korth, Johannes; van Baal, Lukas; Hoffmann, Daniel; Buer, Jan; Witzke, Oliver; Westendorf, Astrid; Kehrmann, Jan
    A Pro-Inflammatory Gut Microbiome Characterizes SARS-CoV-2 Infected Patients and a Reduction in the Connectivity of an Anti-Inflammatory Bacterial Network Associates With Severe COVID-19
    In: Frontiers in Cellular and Infection Microbiology Vol. 11 (2021) 747816
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Pfeiffer, Lukas; Farahpour, Farnoush; Sriram, Ashwin; Spassova, Ivelina; Hoffmann, Daniel; Kubat, Linda; Stoitzner, Patrizia; Gambichler, Thilo; Sucker, Antje; Ugurel, Selma; Schadendorf, Dirk; Becker, Jürgen C.
    BRAF and MEK inhibition in melanoma patients enables reprogramming of tumor infiltrating lymphocytes
    In: Cancer Immunology, Immunotherapy Vol. 70 (2021) Nr. 6, pp. 1635 - 1647
    Online Full Text: dx.doi.org/ (Open Access)
  • Gravemeyer, Jan; Lange, Anja; Ritter, Cathrin; Spassova, Ivelina; Song, Lina; Picard, Daniel; Remke, Marc; Horny, Kai; Sriram, Ashwin; Gambichler, Thilo; Schadendorf, Dirk; Hoffmann, Daniel; Becker, Jürgen
    Classical and Variant Merkel Cell Carcinoma Cell Lines Display Different Degrees of Neuroendocrine Differentiation and Epithelial-Mesenchymal Transition
    In: Journal of Investigative Dermatology Vol. 141 (2021) Nr. 7, pp. 1675 - 1686.e4
    Online Full Text: dx.doi.org/ (Open Access)
  • Tötsch, Niklas; Hoffmann, Daniel
    Classifier uncertainty : Evidence, potential impact, and probabilistic treatment
    In: PeerJ Computer Science Vol. 7 (2021) pp. e398
    Online Full Text: dx.doi.org/ (Open Access)
  • Cao, Yingying; Xu, Xintian; Kitanovski, Simo; Song, Lina; Wang, Jun; Hao, Pei; Hoffmann, Daniel
    Comprehensive Comparison of RNA-Seq Data of SARS-CoV-2, SARS-CoV and MERS-CoV Infections : Alternative Entry Routes and Innate Immune Responses
    In: Frontiers in Immunology Vol. 12 (2021) 656433
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Wülling, Manuela; Neu, Christoph; Thiesen, Andrea M.; Kitanovski, Simo; Cao, Yingying; Lange, Anja; Westendorf, Astrid; Hoffmann, Daniel; Vortkamp, Andrea
    Epigenetic mechanisms mediating cell state transitions in chondrocytes
    In: Journal of Bone and Mineral Research (JBMR) Vol. 36 (2021) Nr. 5, pp. 968 - 985
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Li, Qian; Wang, Jun; Islam, Heba; Kirschning, Carsten Jürgen; Lu, Hongzhou; Hoffmann, Daniel; Dittmer, Ulf; Lu, Mengji
    Hepatitis B virus particles activate B cells through the TLR2–MyD88–mTOR axis
    In: Cell Death and Disease Vol. 12 (2021) Nr. 1, 34
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Budeus, Bettina; Kibler, Artur; Brauser, Martina; Homp, Ekaterina; Bronischewski, Kevin; Ross, J. Alexander; Görgens, Andre; Weniger, Marc; Dunst, Josefine; Kreslavsky, Taras; da Conceição Castro, Symone Vitoriano; Murke, Florian; Oakes, Christopher C.; Rusch, Peter; Andrikos, Dimitrios; Kern, Peter; Köninger, Angela; Lindemann, Monika; Johansson, Patricia; Hansen, Wiebke; Lundell, Anna-Carin; Rudin, Anna; Dürig, Jan; Giebel, Bernd; Hoffmann, Daniel; Küppers, Ralf; Seifert, Marc
    Human cord blood b cells differ from the adult counterpart by conserved ig repertoires and accelerated response dynamics
    In: The Journal of Immunology (JI) Vol. 206 (2021) Nr. 12, pp. 2839 - 2851
    Online Full Text: dx.doi.org/ (Open Access)
  • Duhan, Vikas; Khairnar, Vishal; Kitanovski, Simo; Hamdan, Thamer A.; Klein, Andrés D.; Lang, Judith; Ali, Murtaza; Adomati, Tom; Bhat, Hilal; Friedrich, Sarah-Kim; Li, Fanghui; Krebs, Philippe; Futerman, Anthony H.; Addo, Marylyn M.; Hardt, Cornelia; Hoffmann, Daniel; Lang, Philipp A.; Lang, Karl S.
    Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells
    In: Frontiers in Immunology Vol. 11 (2021) pp. 607889
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Krysztofiak, Adam; Szymonowicz, Klaudia; Hlouschek, Julian; Xiang, Kexu; Waterkamp, Christoph; Larafa, Safa; Goetting, Isabell; Vega-Rubin-de-Celis, Silvia; Theiss, Carsten; Matschke, Veronika; Hoffmann, Daniel; Jendrossek, Verena; Matschke, Johann
    Metabolism of cancer cells commonly responds to irradiation by a transient early mitochondrial shutdown
    In: iScience Vol. 24 (2021) Nr. 11, 103366
    Online Full Text: dx.doi.org/ (Open Access)
  • Kitanovski, Simo; Horemheb-Rubio, Gibran; Adams, Ortwin; Gärtner, Barbara; Lengauer, Thomas; Hoffmann, Daniel; Kaiser, Rolf
    Rhinovirus prevalence as indicator for efficacy of measures against SARS-CoV-2
    In: BMC Public Health Vol. 21 (2021) Nr. 1, 1178
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Meiners, Annika; Bäcker, Sandra; Hadrovic, Inesa; Heid, Christian; Beuck, Christine; Ruiz-Blanco, Yasser B.; Mieres-Perez, Joel; Pörschke, Marius; Grad, Jean-Noël; Vallet, Cecilia; Hoffmann, Daniel; Bayer, Peter; Sánchez-García, Elsa; Schrader, Thomas; Knauer, Shirley
    Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezers
    In: Nature Communications Vol. 12 (2021) Nr. 1, pp. 1505
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Cao, Yingying; Kitanovski, Simo; Küppers, Ralf; Hoffmann, Daniel
    UMI or not UMI, that is the question for scRNA-seq zero-inflation
    In: Nature Biotechnology Vol. 39 (2021) Nr. 2, pp. 158 - 159
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Smolin, Daniel; Tötsch, Niklas; Grad, Jean-Noël; Linders, Jürgen; Kaschani, Farnusch; Kaiser, Markus; Kirsch, Michael; Hoffmann, Daniel; Schrader, Thomas
    Accelerated trypsin autolysis by affinity polymer templates
    In: RSC Advances Vol. 10 (2020) Nr. 48, pp. 28711 - 28719
    Online Full Text: dx.doi.org/ (Open Access)
  • Smolin, Daniel; Tötsch, Niklas; Grad, Jean-Noël; Linders, Jürgen; Kaschani, Farnusch; Kaiser, Markus; Kirsch, Michael; Hoffmann, Daniel; Schrader, Thomas
    Accelerated trypsin autolysis by affinity polymer templates
    In: RSC Advances Vol. 10 (2020) Nr. 48, pp. 28711 - 28719
    Online Full Text: dx.doi.org/ (Open Access)
  • Severmann, Ann-Christine; Jochmann, Katja; Feller, K.; Bachvarova, Velina; Piombo, Virginia; Stange, Richard; Holzer, Tatjana; Brachvogel, Bent; Esko, Jeffrey D.; Pap, Thomas; Hoffmann, Daniel; Vortkamp, Andrea
    An altered heparan sulfate structure in the articular cartilage protects against osteoarthritis
    In: Osteoarthritis and Cartilage Vol. 28 (2020) Nr. 7, pp. 977 - 987
    Online Full Text: dx.doi.org/ (Open Access)
  • Tötsch, Niklas; Hoffmann, Daniel
    Bayesian Data Integration Questions Classic Study on Protease Self-Digest Kinetics
    In: ACS Omega Vol. 5 (2020) Nr. 25, pp. 15162 - 15168
    Online Full Text: dx.doi.org/ (Open Access)
  • Bachvarova, Velina; Dierker, Tabea; Esko, Jeffrey; Hoffmann, Daniel; Kjellen, Lena; Vortkamp, Andrea
    Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate
    In: Matrix Biology Vol. 39 (2020) pp. 43 - 59
    Online Full Text: dx.doi.org/ (Open Access)
  • Wang, Jun; Li, Qian; Yin, Yongmei; Zhang, Yingying; Cao, Yingying; Lin, Xiaoming; Huang, Lihua; Hoffmann, Daniel; Lu, Mengji; Qiu, Yuanwang
    Excessive Neutrophils and Neutrophil Extracellular Traps in COVID-19
    In: Frontiers in Immunology Vol. 11 (2020)
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Kitanovski, Simo; Hoffmann, Daniel
    IgGeneUsage : differential gene usage in immune repertoires
    In: Bioinformatics Vol. 36 (2020) Nr. 11, pp. 3590 - 3591
    Online Full Text: dx.doi.org/
  • Spassova, Ivelina; Ugurel, Selma; Terheyden, Patrick; Sucker, Antje; Hassel, Jessica C.; Ritter, Cathrin; Kubat, Linda; Habermann, Daniel; Farahpour, Farnoush; Saeedghalati, Mohammadkarim; Peiffer, Lukas; Kumar, Rajiv; Schrama, David; Hoffmann, Daniel; Schadendorf, Dirk; Becker, Jürgen C.
    Predominance of Central Memory T Cells with High T-Cell Receptor Repertoire Diversity is Associated with Response to PD-1/PD-L1 Inhibition in Merkel Cell Carcinoma
    In: Clinical Cancer Research Vol. 26 (2020) Nr. 9, pp. 2257 - 2267
    Online Full Text: dx.doi.org/ (Open Access)
  • Mysior, Patryk; Tenberken, Erik; Stecher, Melanie; Vehreschild, Jörg-Janne; Schafberger, Armin; Perea, Ines; Brillen, Anna-Lena; Bartmeyer, Barbara; Esser, Stefan; Bremer, Viviane; Marcus, Ulrich; Hoffmann, Daniel; Streeck, Hendrik
    Rapid uptake of pre-exposure prophylaxis (PrEP) after significant price reduction in Germany highlights importance of PrEP accessibility
    In: AIDS Research and Human Retroviruses (2020)
    Online Full Text: dx.doi.org/
  • Wülling, Manuela; Schneider, Sabine; Schröther, Verena A.; Waterkamp, Christoph; Hoffmann, Daniel; Vortkamp, Andrea
    Wnt5a is a transcriptional target of Gli3 and Trps1 at the onset of chondrocyte hypertrophy
    In: Developmental Biology Vol. 457 (2020) Nr. 1, pp. 104 - 118
    Online Full Text: dx.doi.org/ (Open Access)
  • Cao, Yingying; Kitanovski, Simo; Hoffmann, Daniel;
    intePareto : an R package for integrative analyses of RNA-Seq and ChIP-Seq data
    International Conference on Intelligent Biology and Medicine (ICIBM 2020), 9.-10.08.2020, Virtual,
    In: BMC Genomics Vol. 21 (2020) Nr. Supplement 11, pp. 802
    Online Full Text: dx.doi.org/ (Open Access)
  • Grüneboom, Anika; Hawwari, Ibrahim; Weidner, Daniela; Culemann, Stephan; Müller, Sylvia; Henneberg, Sophie; Brenzel, Alexandra; Merz, Simon; Bornemann, Lea; Zec, Kristina; Wülling, Manuela; Kling, Lasse; Hasenberg, Mike; Voortmann, Sylvia; Lang, Stefanie; Baum, Wolfgang; Ohs, Alexandra; Kraff, Oliver; Quick, Harald H.; Jäger, Marcus; Landgraeber, Stefan; Dudda, Marcel; Danuser, Renzo; Stein, Jens V.; Rohde, Manfred; Gelse, Kolja; Garbe, Annette I.; Adamczyk, Alexandra; Westendorf, Astrid; Hoffmann, Daniel; Christiansen, Silke; Engel, Daniel Robert; Vortkamp, Andrea; Krönke, Gerhard; Herrmann, Martin; Kamradt, Thomas; Schett, Georg; Hasenberg, Anja; Gunzer, Matthias
    A network of trans-cortical capillaries as mainstay for blood circulation in long bones
    In: Nature Metabolism Vol. 1 (2019) Nr. 2, pp. 236 - 250
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Gigante, Alba; Grad, Jean-Noël; Briels, Jeroen; Bartel, Maria; Hoffmann, Daniel; Ottmann, Christian; Schmuck, Carsten
    A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude
    In: Chemical Communications: ChemComm Vol. 55 (2019) Nr. 1, pp. 111 - 114
    Online Full Text: dx.doi.org/
  • Schröder, Nadine; Wülling, Manuela; Hoffmann, Daniel; Brand-Saberi, Beate; Vortkamp, Andrea
    Atoh8 acts as a regulator of chondrocyte proliferation and differentiation in endochondral bones
    In: PLoS ONE Vol. 14 (2019) Nr. 8, pp. e0218230
    Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Xia, Youchen; Pan, Wen; Ke, Xiaoyu; Skibbe, Kathrin; Walker, Andreas; Hoffmann, Daniel; Lu, Yinping; Yang, Xuecheng; Feng, Xuemei; Tong, Qiaoxia; Timm, Jörg; Yang, Dongliang
    Differential escape of HCV from CD8⁺ T cell selection pressure between China and Germany depends on the presenting HLA class I molecule
    In: Journal of Viral Hepatitis Vol. 26 (2019) Nr. 1, pp. 73 - 82
    Online Full Text: dx.doi.org/ (Open Access)
  • Kehrmann, Jan; Menzel, Jannis; Saeedghalati, Mohammadkarim; Obeid, Rima; Schulze, Christina; Holzendorf, Volker; Farahpour, Farnoush; Reinsch, Nico; Klein-Hitpaß, Ludger; Streeck, Hendrik; Hoffmann, Daniel; Buer, Jan; Esser, Stefan
    Gut Microbiota in Human Immunodeficiency Virus-Infected Individuals Linked to Coronary Heart Disease
    In: The Journal of Infectious Diseases (JID) Vol. 219 (2019) Nr. 3, pp. 497 - 508
    Online Full Text: dx.doi.org/ (Open Access)
  • Karimzadeh, Hadi; Kiraithe, Muthamia M.; Oberhardt, Valerie; Salimi Alizei, Elahe; Bockmann, Jan; Schulze zur Wiesch, Julian; Budeus, Bettina; Hoffmann, Daniel; Wedemeyer, Heiner; Cornberg, Markus; Krawczyk, Adalbert; Rashidi-Alavijeh, Jassin; Rodríguez-Frías, Francisco; Casillas, Rosario; Buti, Maria; Smedile, Antonina; Alavian, Seyed Moayed; Heinold, Andreas; Emmerich, Florian; Panning, Marcus; Gostick, Emma; Price, David A.; Timm, Jörg; Hofmann, Maike; Raziorrouh, Bijan; Thimme, Robert; Protzer, Ulrike; Roggendorf, Michael; Neumann-Haefelin, Christoph
    Mutations in Hepatitis D Virus Allow It to Escape Detection by CD8⁺ T Cells and Evolve at the Population Level
    In: Gastroenterology Vol. 156 (2019) Nr. 6, pp. 1820 - 1833
    Online Full Text: dx.doi.org/ (Open Access)
  • Yang, Li; Liu, Feifei; Tong, Xiankun; Hoffmann, Daniel; Zuo, Jianping; Lu, Mengji
    Treatment of Chronic Hepatitis B Virus Infection Using Small Molecule Modulators of Nucleocapsid Assembly : Recent Advances and Perspectives
    In: ACS Infectious Diseases Vol. 5 (2019) Nr. 5, pp. 713 - 724
    Online Full Text: dx.doi.org/
  • Alavian, Seyed Moayed; Price, David A.; Panning, Marcus; Neumann-Haefelin, Christoph; Bockmann, Jan; Wiesch, Julian Schulze zur; Wedemeyer, Heiner; Heinold, Andreas; Alizei, Elahe Salimi; Timm, Jörg; Casillas, Rosario; Protzer, Ulrike; Raziorrouh, Bijan; Smedile, Antonina; Rodríguez-Frías, Francisco; Hoffmann, Daniel; Oberhardt, Valerie; Buti, Maria; Thimme, Robert; Roggendorf, Michael; Hofmann, Maike; Gostick, Emma; Budeus, Bettina; Emmerich, Florian; Kiraithe, Muthamia M.; Karimzadeh, Hadi
    Viral escape contributes to the failure of hepatitis D virus-specific CD8+ T-cells and drives evolution of HDV
    In: Journal of Hepatology Vol. 70 (2019) Nr. Suppl. 1, pp. e21
    Online Full Text: dx.doi.org/
  • Karimzadeh, Hadi; Kiraithe, Muthamia M.; Kosinska, Anna D.; Glaser, Manuel; Fiedler, Melanie; Oberhardt, Valerie; Alizei, Elahe Salimi; Hofmann, Maike; Mok, Juk Yee; Nguyen, Melanie; van Esch, Wim J.E.; Budeus, Bettina; Grabowski, Jan; Homs, Maria; Olivero, Antonella; Keyvani, Hossein; Rodríguez-Frías, Francisco; Tabernero, David; Buti, Maria; Heinold, Andreas; Alavian, Seyed Moayed; Bauer, Tanja; Wiesch, Julian Schulze zur; Raziorrouh, Bijan; Hoffmann, Daniel; Smedile, Antonina; Rizzetto, Mario; Wedemeyer, Heiner; Timm, Jörg; Antes, Iris; Neumann-Haefelin, Christoph; Protzer, Ulrike; Roggendorf, Michael
    Amino acid substitutions within HLA-B*27- restricted T cell epitopes prevent recognition by hepatitis delta virus-specific CD8⁺ T cells
    In: Journal of Virology Vol. 92 (2018) Nr. 13, pp. e01891 - 17
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Tucci, Felicia A.; Kitanovski, Simo; Johansson, Patricia; Klein-Hitpaß, Ludger; Kahraman, Alisan; Dürig, Jan; Hoffmann, Daniel; Küppers, Ralf
    Biased IGH VDJ gene repertoire and clonal expansions in B cells of chronically hepatitis C virus–infected individuals
    In: Blood Vol. 131 (2018) Nr. 5, pp. 546 - 557
    Online Full Text: dx.doi.org/ (Open Access)
  • Wang, Hongye; Yuan, Ting; Li, Tingting; Li, Yanpeng; Qian, Feng; Zhu, Chuanwu; Liang, Shujia; Hoffmann, Daniel; Dittmer, Ulf; Sun, Binlian; Yang, Rongge
    Evaluation of susceptibility of HIV-1 CRF01_AE variants to neutralization by a panel of broadly neutralizing antibodies
    In: Archives of Virology Vol. 163 (2018) Nr. 12, pp. 3303 - 3315
    Online Full Text: dx.doi.org/
  • Dunkel, Thiemo; Lizette de León Gallegos, Erika; Bock, Christina; Lange, Anja; Hoffmann, Daniel; Boenigk, Jens; Denecke, Martin
    Illumina sequencing for the identification of filamentous bulking and foaming bacteria in industrial activated sludge plants
    In: International Journal of Environmental Science and Technology (IJEST) Vol. 15 (2018) Nr. 6, pp. 1139 - 1158
    Online Full Text: dx.doi.org/
  • Grad, Jean-Noël; Gigante, Alba; Wilms, Christoph; Dybowski, Jan Nikolaj; Ohl, Ludwig; Ottmann, Christian; Schmuck, Carsten; Hoffmann, Daniel
    Locating Large, Flexible Ligands on Proteins
    In: Journal of Chemical Information and Modeling Vol. 58 (2018) Nr. 2, pp. 315 - 327
    Online Full Text: dx.doi.org/ (Open Access)
  • Schürmann, Sabine; Steffes, Georg; Manikowski, Dominique; Kastl, Philipp; Malkus, Ursula; Bandari, Shyam; Ohlig, Stefanie; Ortmann, Corinna; Rebollido-Rios, Rocio; Otto, Mandy; Nüsse, Harald; Hoffmann, Daniel; Klämbt, Christian; Galic, Milos; Klingauf, Jürgen; Grobe, Kay
    Proteolytic processing of palmitoylated Hedgehog peptides specifies the 3-4 intervein region of the Drosophila wing
    In: eLife Vol. 7 (2018) pp. e33033
    Online Full Text: dx.doi.org/ (Open Access)
  • Ehlers, Martin; Grad, Jean-Noël; Mittal, Sumit; Bier, David; Mertel, Marcel; Ohl, Ludwig; Bartel, Maria; Briels, Jeroen; Heimann, Marius; Ottmann, Christian; Sánchez-García, Elsa; Hoffmann, Daniel; Schmuck, Carsten
    Rational Design, Binding Studies, and Crystal-Structure Evaluation of the First Ligand Targeting the Dimerization Interface of the 14-3-3ζ Adapter Protein
    In: ChemBioChem Vol. 19 (2018) Nr. 6, pp. 591 - 595
    Online Full Text: dx.doi.org/
  • Piombo, Virginia; Jochmann, Katja; Hoffmann, Daniel; Wülling, Manuela; Vortkamp, Andrea
    Signaling systems affecting the severity of multiple osteochondromas
    In: Bone: Official Journal of the International Bone and Mineral Society (IBMS) Vol. 111 (2018) pp. 71 - 81
    Online Full Text: dx.doi.org/ (Open Access)
  • Farahpour, Farnoush; Saeedghalati, Mohammadkarim; Brauer, Verena S.; Hoffmann, Daniel
    Trade-off shapes diversity in eco-evolutionary dynamics
    In: eLife Vol. 7 (2018) pp. e36273
    Online Full Text: dx.doi.org/ (Open Access)
  • Jakobs, Petra; Schulz, Philipp; Schürmann, Sabine; Niland, Stephan; Exner, Sebastian; Rebollido-Rios, Rocio; Manikowski, Dominique; Hoffmann, Daniel; Seidler, Daniela G.; Grobe, Kay
    Ca2+ coordination controls sonic hedgehog structure and its Scube2-regulated release
    In: Journal of Cell Science Vol. 130 (2017) Nr. 19, pp. 3261 - 3271
    Online Full Text: dx.doi.org/ (Open Access)
  • Drabczyk-Pluta, Malgorzata; Werner, Tanja; Hoffmann, Daniel; Leng, Qibin; Chen, Lieping; Dittmer, Ulf; Zelinskyy, Gennadiy
    Granulocytic myeloid-derived suppressor cells suppress virus-specific CD8+ T cell responses during acute Friend retrovirus infection
    In: Retrovirology Vol. 14 (2017) 42
    Online Full Text: dx.doi.org/ (Open Access)
  • Nemec, Mike; Hoffmann, Daniel
    Quantitative Assessment of Molecular Dynamics Sampling for Flexible Systems
    In: Journal of Chemical Theory and Computation Vol. 13 (2017) Nr. 2, pp. 400 - 414
    Online Full Text: dx.doi.org/
  • Saeedghalati, Mohammadkarim; Farahpour, Farnoush; Budeus, Bettina; Lange, Anja; Westendorf, Astrid; Seifert, Marc; Küppers, Ralf; Hoffmann, Daniel
    Quantitative Comparison of Abundance Structures of Generalized Communities : from B-Cell Receptor Repertoires to Microbiomes
    In: PLoS Computational Biology Vol. 13 (2017) Nr. 1, e1005362
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Kletenkov, K.; Hoffmann, Daniel; Böni, Jürg; Yerly, Sabine; Aubert, Vincent; Schöni-Affolter, Franziska; Struck, Daniel; Verheyen, Jens; Klimkait, Thomas H.
    Role of Gag mutations in PI resistance in the Swiss HIV cohort study : bystanders or contributors?
    In: Journal of Antimicrobial Chemotherapy Vol. 72 (2017) Nr. 3, pp. 866 - 875
    Online Full Text: dx.doi.org/ (Open Access)
  • Großmann, Lars; Jensen, Manfred; Heider, Dominik; Jost, Steffen; Glücksmann, Edvard; Hartikainen, Hanna; Mahamdallie, Shazia S.; Gardner, Michelle; Hoffmann, Daniel; Bass, David; Boenigk, Jens
    Protistan community analysis : key findings of a large scale molecular sampling
    In: ISME Journal Vol. 10 (2016) pp. 2269 - 2279
    Online Full Text: dx.doi.org/ (Open Access)
  • Budeus, Bettina; Timm, Jörg; Hoffmann, Daniel
    SeqFeatR for the Discovery of Feature-Sequence Associations
    In: PLoS ONE Vol. 11 (2016) Nr. 1, pp. e0146409
    Online Full Text: dx.doi.org/ (Open Access)
  • Kefalakes, Helenie; Budeus, Bettina; Walker, Andreas; Jochum, Christoph; Hilgard, Gudrun; Heinold, Andreas; Heinemann, Falko M.; Gerken, Guido; Hoffmann, Daniel; Timm, Jörg
    Adaptation of the Hepatitis B Virus Core Protein to CD8+ T-Cell Selection Pressure
    In: Hepatology Vol. 62 (2015) Nr. 1, pp. 47 - 56
    Online Full Text: dx.doi.org/ (Open Access)
  • Lange, Anja; Jost, Steffen Oliver; Heider, Dominik; Bock, Christina; Budeus, Bettina; Schilling, Elmar; Strittmatter, Axel; Boenigk, Jens; Hoffmann, Daniel
    AmpliconDuo : a split-sample filtering protocol for high-throughput amplicon sequencing of microbial communities
    In: PLoS ONE Vol. 10 (2015) Nr. 11, pp. e0141590
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  • Budeus, Bettina; De Reynoso, Stefanie Schweigle; Przekopowitz, Martina; Hoffmann, Daniel; Seifert, Marc; Küppers, Ralf
    Complexity of the human memory B-cell compartment is determined by the versatility of clonal diversification in germinal centers
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 112 (2015) Nr. 38, pp. E5281 - E5289
    Online Full Text: dx.doi.org/ (Open Access)
  • Sierra, Saleta; Dybowski, J. Nikolai; Pironti, Alejandro; Heider, Dominik; Güney, Lisa; Thielen, Alex; Reuter, Stefan; Esser, Stefan; Fätkenheuer, Gerd; Lengauer, Thomas; Hoffmann, Daniel; Pfister, Herbert; Jensen, Björn; Kaiser, Rolf
    Parameters influencing baseline HIV-1 genotypic tropism testing related to clinical outcome in patients on maraviroc
    In: PLoS ONE Vol. 10 (2015) Nr. 5, pp. e0125502
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  • Klammer, Martin; Dybowski, Jan Nikolaj; Hoffmann, Daniel; Schaab, Christoph
    Pareto optimization identifies diverse set of phosphorylation signatures predicting response to treatment with dasatinib
    In: PLoS ONE Vol. 10 (2015) Nr. 6, pp. e0128542
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  • Merches, Katja; Khairnar, Vishal; Knuschke, Torben; Shaabani, Namir; Honke, Nadine; Duhan, Vikas; Recher, Mike; Navarini, Alexander A.; Hardt, Cornelia; Häussinger, Dieter; Tümmler, Burkhard; Gulbins, Erich; Futerman, Anthony H.; Hoffmann, Daniel; Lang, Florian; Lang, Philipp A.; Westendorf, Astrid; Lang, Karl S.
    Virus-induced type i interferon deteriorates control of systemic pseudomonas aeruginosa infection
    In: Cellular Physiology and Biochemistry Vol. 36 (2015) Nr. 6, pp. 2379 - 2392
    Online Full Text: dx.doi.org/ (Open Access)
  • Heider, Dominik; Dybowski, Jan Nikolaj; Wilms, Christoph; Hoffmann, Daniel
    A simple structure-based model for the prediction of HIV-1 co-receptor tropism
    In: BioData Mining Vol. 7 (2014) pp. 14
    Online Full Text: dx.doi.org/ (Open Access)
  • Dang, S.; Wang, Yan; Budeus, Bettina; Verheyen, Jens; Yang, R.; Hoffmann, Daniel
    Differential selection in HIV-1 gp120 between subtype B and East Asian variant B'
    In: Virologica Sinica Vol. 29 (2014) Nr. 1, pp. 40 - 47
    Online Full Text: dx.doi.org/
  • Skibbe, K.; Budeus, Bettina; Heinemann, Falko M.; Timmer, L.; Horn, Peter; van Esch, W.; Hoffmann, Daniel; Siemann, H.; Scherbaum, Norbert; Timm, Jörg
    HLA-B*27 is protective against HCV genotype 1 and 3 and associated with targeting of distinct genotype-specific CD8(+) cell epitopes
    In: Journal of Hepatology Vol. 60 (2014) Nr. Suppl. 1, pp. 140
    Online Full Text: dx.doi.org/
  • Klammer, Martin; Dybowski, Jan Nikolaj; Hoffmann, Daniel; Schaab, Christoph
    Identification of Significant Features by the Global Mean Rank Test
    In: PLoS ONE Vol. 9 (2014) Nr. 8, pp. e104504
    Online Full Text: dx.doi.org/ (Open Access)
  • Rebollido-Rios, Rocio; Bandari, Shyam; Wilms, Christoph; Jakuschev, Stanislav; Vortkamp, Andrea; Grobe, Kay; Hoffmann, Daniel
    Signaling Domain of Sonic Hedgehog as Cannibalistic Calcium-Regulated Zinc-Peptidase
    In: PLoS Computational Biology Vol. 10 (2014) Nr. 7, pp. e1003707
    Online Full Text: dx.doi.org/ (Open Access)
  • Wang, Yan; Rawi, Reda; Wilms, Christoph; Heider, Dominik; Yang, Rongge; Hoffmann, Daniel
    A Small Set of Succinct Signature Patterns Distinguishes Chinese and Non-Chinese HIV-1 Genomes
    In: PLoS ONE Vol. 8 (2013) Nr. 3, pp. e58804
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  • Jiang, Qian-Qian; Bartsch, Lina; Sicking, Wilhelm; Wich, Peter R.; Heider, Dominik; Hoffmann, Daniel; Schmuck, Carsten
    A new approach to inhibit human β-tryptase by protein surface binding of four-armed peptide ligands with two different sets of arms
    In: Organic and Biomolecular Chemistry Vol. 11 (2013) Nr. 10, pp. 1631 - 1639
    Online Full Text: dx.doi.org/
  • Wang, Yan; Rawi, Reda; Wilms, Christoph; Heider, Dominik; Yang, Rongge; Hoffmann, Daniel
    Correction: A Small Set of Succinct Signature Patterns Distinguishes Chinese and Non-Chinese HIV-1 Genomes.
    In: PLoS ONE Vol. 8 (2013) Nr. 12,
    Online Full Text: dx.doi.org/ (Open Access)
  • Grum, Daniel; Franke, Stefan; Kraff, Oliver; Heider, Dominik; Schramm, Alexander; Hoffmann, Daniel; Bayer, Peter
    Design of a Modular Protein-Based MRI Contrast Agent for Targeted Application
    In: PLoS ONE Vol. 8 (2013) Nr. 6, pp. e65346
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Wang, Yan; Rawi, Reda; Hoffmann, Daniel; Sun, Binlian; Yang, Rongge
    Inference of global HIV-1 sequence patterns and preliminary feature analysis
    In: Virologica Sinica Vol. 28 (2013) Nr. 4, pp. 228 - 238
    Online Full Text: dx.doi.org/
  • Sowa, Jan-Peter; Heider, Dominik; Bechmann, Lars Peter; Gerken, Guido; Hoffmann, Daniel; Canbay, Aliekber
    Novel Algorithm for Non-Invasive Assessment of Fibrosis in NAFLD
    In: PLoS ONE Vol. 8 (2013) Nr. 4, pp. e62439
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  • Qin, Bo; Budeus, Bettina; Cao, Liang; Wu, Chunchen; Wang, Yun; Zhang, Xiaoyong; Rayner, Simon; Hoffmann, Daniel; Lu, Mengji; Chen, Xinwen
    The amino acid substitutions rtP177G and rtF249A in the reverse transcriptase domain of hepatitis B virus polymerase reduce the susceptibility to tenofovir
    In: Antiviral Research Vol. 97 (2013) Nr. 2, pp. 93 - 100
    Online Full Text: dx.doi.org/
  • Matena, Anja; Sinnen, Christian; van den Boom, Johannes; Wilms, Christoph; Dybowski, Jan Nikolaj; Maltaner, Ricarda; Müller, Jonathan W.; Link, Nina M.; Hoffmann, Daniel; Bayer, Peter
    Transient domain interactions enhance the affinity of the mitotic regulator pin1 toward phosphorylated peptide ligands
    In: Structure Vol. 21 (2013) Nr. 10, pp. 1769 - 1777
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  • Ohlig, Stefanie; Pickhinke, Ute; Sirko, Svetlana; Bandari, Shyam; Hoffmann, Daniel; Dreier, Rita; Farshi, Pershang; Götz, Magdalena; Grobe, Kai
    An emerging role of sonic hedgehog shedding as a modulator of heparan sulfate interactions
    In: The Journal of Biological Chemistry (JBC) Vol. 287 (2012) Nr. 52, pp. 43708 - 43719
    Online Full Text: dx.doi.org/
  • Ruhl, Marianne; Chhatwal, Patrick; Strathmann, Heiko; Kuntzen, Thomas; Bankwitz, Dorothea; Skibbe, Kathrin; Walker, Andreas; Heinemann, Falko M.; Horn, Peter; Allen, Todd M.; Hoffmann, Daniel; Pietschmann, Thomas; Timm, Jörg
    Escape from a dominant hla-b*15-restricted cd8+ t cell response against hepatitis c virus requires compensatory mutations outside the epitope
    In: Journal of Virology Vol. 86 (2012) Nr. 2, pp. 991 - 1000
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  • Genheden, Samuel; Kuhn, Oliver; Mikulskis, Paulius; Hoffmann, Daniel; Ryde, Ulf
    The Normal-Mode Entropy in the MM/GBSA Method : Effect of System Truncation, Buffer Region, and Dielectric Constant
    In: Journal of Chemical Information and Modeling Vol. 52 (2012) Nr. 8, pp. 2079 - 2088
    Online Full Text: dx.doi.org/ (Open Access)
  • Neumann, Lisa; Markaki, Yolanda; Mladenov, Emil; Hoffmann, Daniel; Buiting, Karin; Horsthemke, Bernhard
    The imprinted NPAP1/C15orf2 gene in the Prader-Willi syndrome region encodes a nuclear pore complex associated protein
    In: Human Molecular Genetics Vol. 21 (2012) Nr. 18, pp. 4038 - 4048
    Online Full Text: dx.doi.org/ (Open Access)
  • Haferkamp, Patrick; Kutschki, Simone; Treichel, Jenny; Hemeda, Hatim; Sewczyk, Karsten; Hoffmann, Daniel; Zaparty, Melanie; Siebers, Bettina
    An additional glucose dehydrogenase from Sulfolobus solfataricus : fine-tuning of sugar degradation?
    In: Biochemical Society Transactions Vol. 39 (2011) Nr. 1, pp. 77 - 81
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  • Lättig-Tünnemann, Gisela; Prinz, Manuel; Hoffmann, Daniel; Behlke, Joachim; Palm-Apergi, Caroline; Morano, Ingo; Herce, Henry D.; Cardoso, M. Cristina
    Backbone rigidity and static presentation of guanidinium groups increases cellular uptake of arginine-rich cell-penetrating peptides
    In: Nature Communications Vol. 2 (2011) pp. 453
    Online Full Text: dx.doi.org/ (Open Access)
  • Ruhl, Marianne; Knuschke, Torben; Schewior, Kevin; Glavinic, Lejla; Neumann-Haefelin, Christoph; Chang, Dae-In; Klein, Marina; Heinemann, Falko M.; Tenckhoff, Hannelore; Wiese, Manfred; Horn, Peter A.; Viazov, Sergey; Spengler, Ulrich; Roggendorf, Michael; Scherbaum, Norbert; Nattermann, Jacob; Hoffmann, Daniel; Timm, Jörg; East German HCV Study Group
    CD8+ T-Cell Response Promotes Evolution of Hepatitis C Virus Nonstructural Proteins
    In: Gastroenterology Vol. 140 (2011) Nr. 7, pp. 2064 - 2073
    Online Full Text: dx.doi.org/
  • Dybowski, Jan Nikolaj; Riemenschneider, Mona; Hauke, Sascha; Pyka, Martin; Verheyen, Jens; Hoffmann, Daniel; Heider, Dominik
    Improved Bevirimat resistance prediction by combination of structural and sequence-based classifiers
    In: BioData Mining Vol. 4 (2011) Nr. 1, pp. 26
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Heider, Dominik; Hoffmann, Daniel
    Interpol : An R package for preprocessing of protein sequences
    In: BioData Mining Vol. 4 (2011) pp. 16
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Heider, Dominik; Verheyen, Jens; Hoffmann, Daniel
    Machine learning on normalized protein sequences
    In: BMC Research Notes Vol. 4 (2011) pp. 94
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  • Horsthemke, Bernhard; Wawrzik, Michaela; Groß, Stephanie; Lich, Christina; Sauer, Birgitta; Rost, Imma; Krasemann, Ernst; Kosyakowa, Nadezda; Liehr, Thomas; Weise, Anja; Dybowski, Jan Nikolaj; Hoffmann, Daniel; Wieczorek, Dagmar
    Parental origin and functional relevance of a de novo UBE3A variant
    In: European Journal of Medical Genetics (EJMG) Vol. 54 (2011) Nr. 1, pp. 19 - 24
    Online Full Text: dx.doi.org/
  • Lederer, Christoph; Heider, Dominik; van den Boom, Johannes; Hoffmann, Daniel; Müller, Jonathan W.; Bayer, Peter
    Single-Domain Parvulins Constitute a Specific Marker for Recently Proposed Deep-Branching Archaeal Subgroups
    In: Evolutionary Bioinformatics Vol. 7 (2011) pp. 135 - 148
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  • Ohlig, Stefanie; Farshi, Pershang; Pickhinke, Ute; van den Boom, Johannes; Höing, Susanne; Jakuschev, Stanislav; Hoffmann, Daniel; Dreier, Rita; Schöler, Hans R.; Dierker, Tabea; Bordych, Christian; Grobe, Kay
    Sonic hedgehog shedding results in functional activation of the solubilized protein
    In: Developmental Cell Vol. 20 (2011) Nr. 6, pp. 764 - 774
    Online Full Text: dx.doi.org/ (Open Access)
  • Franke, Stefan; Herfurth, Julia; Hoffmann, Daniel
    Estimating affinities of calcium ions to proteins
    In: Advances and Applications in Bioinformatics and Chemistry Vol. 3 (2010) Nr. 1, pp. 1 - 6
    Online Full Text: dx.doi.org/ (Open Access)
  • Heider, Dominik; Verheyen, Jens; Hoffmann, Daniel
    Predicting Bevirimat resistance of HIV-1 from genotype
    In: BMC Bioinformatics Vol. 11 (2010) pp. 37
    Online Full Text: dx.doi.org/ (Open Access)
  • Dybowski, Jan Nikolaj; Heider, Dominik; Hoffmann, Daniel
    Prediction of Co-Receptor Usage of HIV-1 from Genotype
    In: PLoS Computational Biology Vol. 6 (2010) Nr. 4, pp. e1000743
    Online Full Text: dx.doi.org/ (Open Access)
  • Ehrentraut, Stefan; Weber, Jan; Dybowski, Jan Nikolaj; Hoffmann, Daniel; Ehrenhofer-Murray, Ann
    Rpd3-dependent boundary formation at telomeres by removal of Sir2 substrate
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 107 (2010) Nr. 12, pp. 5522 - 5527
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  • Dybowski, Jan Nikolaj; Heider, Dominik; Hoffmann, Daniel
    Structure of HIV-1 quasi-species as early indicator for switches of co-receptor tropism.
    In: AIDS Research and Therapy Vol. 7 (2010) pp. 41
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  • Drogan, Daniel; Rauch, Pia; Hoffmann, Daniel; Walter, Hauke; Metzner, Karin J.
    The antiretroviral potency of emtricitabine is approximately 3-fold higher compared to lamivudine in dual human immunodeficiency virus type 1 infection/competition experiments in vitro
    In: Antiviral Research Vol. 86 (2010) Nr. 3, pp. 312 - 315
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  • Schirling, Corinna; Heseding, Christiane; Heise, Franziska; Kesper, Dörthe; Klebes, Ansgar; Klein-Hitpaß, Ludger; Vortkamp, Andrea; Hoffmann, Daniel; Saumweber, Harald; Ehrenhofer-Murray, Ann
    Widespread regulation of gene expression in the Drosophila genome by the histone acetyltransferase dTip60
    In: Chromosoma Vol. 119 (2010) Nr. 1, pp. 99 - 113
    Online Full Text: dx.doi.org/
  • Jakuschev, Stanislav; Hoffmann, Daniel
    A novel algorithm for macromolecular epitope matching
    In: Algorithms Vol. 2 (2009) Nr. 1, pp. 498 - 517
    Online Full Text: dx.doi.org/
  • Verheyen, Jens; Knops, Elena; Kupfer, Bernd; Hamouda, Osamah; Somogyi, Sybille; Schuldenzucker, Ulrike; Hoffmann, Daniel; Kaiser, Rolf; Pfister, Herbert; Kücherer, Claudia
    Prevalence of C-terminal gag cleavage site mutations in HIV from therapy-naïve patients
    In: Journal of Infection Vol. 58 (2009) Nr. 1, pp. 61 - 67
    Online Full Text: dx.doi.org/
  • Balduin, Melanie; Oette, Mark; Däumer, Martin P.; Hoffmann, Daniel; Pfister, Herbert J.; Kaiser, Rolf
    Prevalence of minor variants of HIV strains at reverse transcriptase position 103 in therapy-naïve patients and their impact on the virological failure
    In: Journal of Clinical Virology Vol. 45 (2009) Nr. 1, pp. 34 - 38
    Online Full Text: dx.doi.org/
  • Fischer, Sven; Kohlhase, Jürgen; Böhm, Detlef; Schweiger, Bernd; Hoffmann, Daniel; Heitmann, Melanie; Horsthemke, Bernhard; Wieczorek, Dagmar
    Biallelic loss of function of the promyelocytic leukaemia zinc finger (PLZF) gene causes severe skeletal defects and genital hypoplasia
    In: Journal of Medical Genetics (eJMG) Vol. 45 (2008) Nr. 11, pp. 731 - 737
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  • Hoffmann, Daniel
    Evolution : von der Biologie zur Mathematik und wieder zurück ; die Ergebnisse der Evolutionstheorie sind heute nicht nur Naturbeschreibung, sondern auch mathematisches Werkzeug
    In: Unikate: Berichte aus Forschung und Lehre (2008) Nr. 33: Mathematik: eine lebendige Wissenschaft, pp. 54 - 65
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  • Gronwald, Wolfram; Hohm, Tim; Hoffmann, Daniel
    Evolutionary Pareto-optimization of stably folding peptides
    In: BMC Bioinformatics Vol. 9 (2008) pp. 109
    Online Full Text: dx.doi.org/ (Open Access)
  • Albert, Thilo; Egler, Christian; Jakuschev, Stanislav; Schuldenzucker, Ulrike; Schmitt, Alexandra; Brokemper, Oliver; Zabe-Kuhn, Martin; Hoffmann, Daniel; Oldenburg, Johannes; Schwaab, Rainer
    The B-cell epitope of the monoclonal anti-factor VIII anti- body ESH8 characterized by peptide array analysis
    In: Thrombosis and Haemostasis Vol. 99 (2008) Nr. 3, pp. 634 - 637
    Online Full Text: dx.doi.org/
  • Hohm, Tim; Limbourg, Philipp; Hoffmann, Daniel
    A multiobjective evolutionary method for the design of peptidic mimotopes
    In: Journal of Computational Biology Vol. 13 (2006) Nr. 1, pp. 113 - 125
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  • Verheyen, Jens; Litau, Elena; Sing, Tobias; Däumer, Martin; Balduin, Melanie; Oette, Mark; Fätkenheuer, Gerd; Rockstroh, Jürgen K.; Schuldenzucker, Ulrike; Hoffmann, Daniel; Pfister, Herbert; Kaiser, Rolf
    Compensatory mutations at the HIV cleavage sites p7/p1 and p1/p6-gag in therapy-naive and therapy-experienced patients.
    In: Antiviral Therapy Vol. 11 (2006) Nr. 7, pp. 879 - 887
  • Wefing, Stephan; Schnaible, Volker; Hoffmann, Daniel
    SearchXLinks : A program for the identification of disulfide bonds in proteins from mass spectra
    In: Analytical Chemistry Vol. 78 (2006) Nr. 4, pp. 1235 - 1241
    Online Full Text: dx.doi.org/
  • Wendeler, Michaela; Werth, Norbert; Maier, Timm; Schwarzmann, Guenter; Kolter, Thomas; Schoeniger, Maike; Hoffmann, Daniel; Lemm, Thorsten; Saenger, Wolfram; Sandhoff, Konrad
    The enzyme-binding region of human GM2-activator protein
    In: The FEBS Journal Vol. 273 (2006) Nr. 5, pp. 982 - 991
    Online Full Text: dx.doi.org/
  • Beerenwinkel, Niko; Sing, Tobias; Lengauer, Thomas; Rahnenführer, Jörg; Roomp, Kirsten; Savenkov, Igor; Fischer, Roman; Hoffmann, Daniel; Selbig, Joachim; Korn, Klaus; Walter, Hauke; Berg, Thomas; Braun, Patrick; Fätkenheuer, Gerd; Oette, Mark; Rockstroh, Jürgen; Kupfer, Bernd; Kaiser, Rolf; Däumer, Martin
    Computational methods for the design of effective therapies against drug resistant HIV strains
    In: Bioinformatics Vol. 21 (2005) Nr. 21, pp. 3943 - 3950
    Online Full Text: dx.doi.org/ (Open Access)
  • Beerenwinkel, Niko; Däumer, Martin; Sing, Tobias; Rahnenführer, Jörg; Lengauer, Thomas; Selbig, Joachim; Hoffmann, Daniel; Kaiser, Rolf
    Estimating HIV evolutionary pathways and the genetic barrier to drug resistance
    In: Journal of Infectious Diseases Vol. 191 (2005) Nr. 11, pp. 1953 - 1960
    Online Full Text: dx.doi.org/ (Open Access)
  • Balduin, Melanie; Sierra, Saleta; Daumer, Martin P.; Rockstroh, Jürgen K.; Oette, Mark; Fätkenheuer, Gerd; Kupfer, Bernd; Beerenwinkel, Niko; Hoffmann, Daniel; Selbig, Joachim; Pfister, Herbert J.; Kaiser, Rolf
    Evolution of HIV resistance during treatment interruption in experienced patients and after restarting a new therapy
    In: Journal of Clinical Virology Vol. 34 (2005) Nr. 4, pp. 277 - 287
    Online Full Text: dx.doi.org/
  • Beerenwinkel, Niko; Rahnenführer, Jörg; Däumer, Martin; Hoffmann, Daniel; Kaiser, Rolf; Selbig, Joachim; Lengauer, Thomas
    Learning multiple evolutionary pathways from cross-sectional data
    In: Journal of Computational Biology Vol. 12 (2005) Nr. 6, pp. 584 - 598
    Online Full Text: dx.doi.org/
  • Beerenwinkel, Niko; Rahnenführer, Jörg; Kaiser, Rolf; Hoffmann, Daniel; Selbig, Joachim; Lengauer, Thomas
    Mtreemix : A software package for learning and using mixture models of mutagenetic trees
    In: Bioinformatics Vol. 21 (2005) Nr. 9, pp. 2106 - 2107
    Online Full Text: dx.doi.org/ (Open Access)
  • Wendeler, Michaela; Hoernschemeyer, Joerg; Hoffmann, Daniel; Kolter, Thomas; Schwarzmann, Guenter; Sandhoff, Konrad
    Photoaffinity labelling of the Human GM2-activator protein Mechanistic insight into ganglioside GM2 degradation
    In: European Journal of Biochemistry: the FEBS journal Vol. 271 (2004) Nr. 3, pp. 614 - 627
    Online Full Text: dx.doi.org/
  • Beerenwinkel, Niko; Däumer, Martin; Oette, Mark; Korn, Klaus; Hoffmann, Daniel; Kaiser, Rolf; Lengauer, Thomas; Selbig, Joachim; Walter, Hauke
    Geno2pheno : Estimating phenotypic drug resistance from HIV-1 genotypes
    In: Nucleic Acids Research Vol. 31 (2003) Nr. 13, pp. 3850 - 3855
    Online Full Text: dx.doi.org/
  • Beerenwinkel, Niko; Lengauer, Thomas; Däumer, Martin; Kaiser, Rolf; Walter, Hauke; Korn, Klaus; Hoffmann, Daniel; Selbig, Joachim
    Methods for optimizing antiviral combination therapies
    In: Bioinformatics Vol. 19 (2003) Nr. Suppl 1, pp. i16 - i25
    Online Full Text: dx.doi.org/ (Open Access)
  • Albrecht, Mario; Hoffmann, Daniel; Evert, Bernd O.; Schmitt, Ina; Wüllner, Ullrich; Lengauer, Thomas
    Structural modeling of ataxin-3 reveals distant homology to adaptins
    In: Proteins: Structure, Function and Genetics Vol. 50 (2003) Nr. 2, pp. 355 - 370
    Online Full Text: dx.doi.org/
  • Wolf, Katharina; Walter, Hauke; Beerenwinkel, Niko; Keulen, Wilco; Kaiser, Rolf; Hoffmann, Daniel; Lengauer, Thomas; Selbig, Joachim; Vandamme, Anne-Mieke; Korn, Klaus; Schmidt, Barbara
    Tenofovir Resistance and Resensitization
    In: Antimicrobial Agents and Chemotherapy Vol. 47 (2003) Nr. 11, pp. 3478 - 3484
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Beerenwinkel, Niko; Schmidt, Barbara; Walter, Hauke; Kaiser, Rolf; Lengauer, Thomas; Hoffmann, Daniel; Korn, Klaus; Selbig, Joachim
    Diversity and complexity of HIV-1 drug resistance: A bioinformatics approach to predicting phenotype from genotype
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 99 (2002) Nr. 12, pp. 8271 - 8276
    Online Full Text: dx.doi.org/
  • Schnaible, Volker; Wefing, Stephan; Bücker, Anne; Wolf-Kümmeth, Sybille; Hoffmann, Daniel
    Partial reduction and two-step modification of proteins for identification of disulfide bonds
    In: Analytical Chemistry Vol. 74 (2002) Nr. 10, pp. 2386 - 2393
    Online Full Text: dx.doi.org/
  • Schnaible, Volker; Wefing, Stephan; Resemann, Anja; Suckau, Detlev; Bücker, Anne; Wolf-Kümmeth, Sybille; Hoffmann, Daniel
    Screening for disulfide bonds in proteins by MALDI in-source decay and LIFT-TOF/TOF-MS
    In: Analytical Chemistry Vol. 74 (2002) Nr. 19, pp. 4980 - 4988
    Online Full Text: dx.doi.org/
  • Hoffmann, Daniel
    Web Site : The Protein Information Resource
    In: Angewandte Chemie International Edition Vol. 41 (2002) Nr. 6, pp. 1075 - 1075
    Online Full Text: dx.doi.org/
  • Beerenwinkel, Niko; Lengauer, Thomas; Selbig, Joachim; Schmidt, Barbara; Walter, Hauke; Korn, Klaus; Kaiser, Rolf; Hoffmann, Daniel
    Geno2pheno : Interpreting Genotypic HIV Drug Resistance Tests
    In: IEEE Intelligent Systems Vol. 16 (2001) Nr. 6, pp. 35 - 41
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Beerenwinkel, Niko; Däumer, Martin; Hoffmann, Daniel; Kaiser, Rolf; Korn, Klaus; Lengauer, Thomas; Schmidt, Barbara; Walter, Hauke; Selbig, Joachim
    Neue Wege zur Optimierung von Anti-HIV-Therapien : Erste Analysen mit bioinformatischen Methoden
    In: BIOforum Vol. 24 (2001) Nr. 12, pp. 912 - 914
  • Jacob, Joël; Geßler, Katrin; Hoffmann, Daniel; Sanbe, Haruyo; Koizumi, Kyoko; Smith, Steven M.; Takaha, Takeshi; Saenger, Wolfram; Geβler, Katrin
    Band-flip and kink as novel structural motifs in α-(1→4)-D-glucose oligosaccharides. Crystal structures of cyclodeca- and cyclotetradecaamylose
    In: Carbohydrate Research Vol. 322 (1999) Nr. 3-4, pp. 228 - 246
    Online Full Text: dx.doi.org/
  • Hoffmann, Daniel; Kramer, B.; Washio, T.; Steinmetzer, T.; Rarey, M.; Lengauer, T.
    Two-Stage Method for Protein-Ligand Dockin
    In: (J. Med. Chem.) Vol. 42 (1999) pp. 4422 - 4433
  • Hoffmann, Daniel; Kramer, Bernd; Washio, Takumi; Steinmetzer, Torsten; Rarey, Matthias; Lengauer, Thomas
    Two-stage method for protein-ligand docking
    In: Journal of Medicinal Chemistry Vol. 42 (1999) Nr. 21, pp. 4422 - 4433
    Online Full Text: dx.doi.org/
  • Hoffmann, Daniel; Flörke, Holger
    A structural role for glycosylation : Lessons from the hp model
    In: Folding and Design Vol. 3 (1998) Nr. 5, pp. 337 - 343
    Online Full Text: dx.doi.org/ (Open Access)
  • Hoffmann, Daniel; Flörke, H.
    A structural role for glycosylation: lessons from the hp-mode
    In: Folding & Design Vol. 3 (1998) pp. 337 - 343
  • Jacob, Joël; Geßler, Katrin; Hoffmann, Daniel; Sanbe, Haruyo; Koizumi, Kyoko; Smith, Steven M.; Takaha, Takeshi; Saenger, Wolfram
    Strain-Induced “Band Flips” in Cyclodecaamylose and Higher Homologues
    In: Angewandte Chemie International Edition Vol. 37 (1998) Nr. 5,
    Online Full Text: dx.doi.org/
  • Saenger, W.; Jacob, J.; Gessler, K.; Steiner, T.; Hoffmann, Daniel; Sanbe, H.; Koizumi, K.; Smith, S.M.; Takaha, T.
    Structures of the Common Cyclodextrins and Their Larger Analogues -- Beyond the Doughnu
    In: Chemical Reviews Vol. 98 (1998) pp. 1787 - 1802
  • Saenger, Wolfram; Jacob, Joël; Gessler, Katrin; Steiner, Thomas; Hoffmann, Daniel; Sanbe, Haruyo; Koizumi, Kyoko; Smith, Steven M.; Takaha, Takeshi
    Structures of the common cyclodextrins and their larger analogues : beyond the doughnut
    In: Chemical Reviews Vol. 98 (1998) Nr. 5, pp. 1787 - 1802
    Online Full Text: dx.doi.org/
  • Hoffmann, Daniel; Knapp, Ernst-Walter
    Folding Pathways of a Helix-Turn-Helix Model Protein
    In: Journal of Physical Chemistry B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical Chemistry Vol. 101 (1997) Nr. 34, pp. 6734 - 6740
    Online Full Text: dx.doi.org/ (Open Access)
  • Hoffmann, Daniel; Knapp, Ernst-Walter
    Polypeptide folding with-off lattice Monte Carlo dynamics : The method
    In: European Biophysics Journal Vol. 24 (1996) Nr. 6, pp. 387 - 403
    Online Full Text: dx.doi.org/
  • Hoffmann, Daniel; Knapp, Ernst-Walter
    Protein dynamics with off-lattice monte carlo moves
    In: Physical Review E: Statistical, nonlinear, and soft matter physics Vol. 53 (1996) Nr. 4, pp. 4221 - 4224
    Online Full Text: dx.doi.org/ (Open Access)

    • Book articles / Proceedings papers

  • Roomp, Kirsten; Beerenwinkel, Niko; Sing, Tobias; Schülter, Eugen; Büch, Joachim; Sierra-Aragon, Saleta; Däumer, Martin; Hoffmann, Daniel; Kaiser, Rolf; Lengauer, Thomas; Selbig, Joachim
    Arevir : A Secure Platform for Designing Personalized Antiretroviral Therapies Against HIV
    In: Data Integration in the Life Sciences / Third International Workshop (DILS), July 20-22, 2006, Hinxton, UK, / Leser, Ulf; Naumann, Felix; Eckman, Barbara (Eds.) 2006, pp. 185 - 194
    Online Full Text: dx.doi.org/
  • Hohm, Tim; Hoffmann, Daniel
    A multi-objective evolutionary approach to peptide structure redesign and stabilization
    In: Proceedings of the 7th annual conference on Genetic and evolutionary computation / GECCO 2005 - Genetic and Evolutionary Computation Conference, 25-29 June 2005, Washington D.C., United States / Beyer, Hans-Georg (Eds.) 2005, pp. 423 - 429
    Online Full Text: dx.doi.org/
  • Sing, Tobias; Svicher, Valentina; Beerenwinkel, Niko; Ceccherini-Silberstein, Francesca; Däumer, Martin; Kaiser, Rolf; Walter, Hauke; Korn, Klaus; Hoffmann, Daniel; Oette, Mark; Rockstroh, Jürgen K.; Fätkenheuer, Gert; Perno, Carlo-Federico; Lengauer, Thomas
    Characterization of Novel HIV Drug Resistance Mutations Using Clustering, Multidimensional Scaling and SVM-Based Feature Ranking
    In: Knowledge Discovery in Databases: PKDD 2005: th European Conference on Principles and Practice of Knowledge Discovery in Databases, Porto, Portugal, October 3-7, 2005. Proceedings / 9th European Conference on Principles and Practice of Knowledge Discovery in Databases (PKDD 2005), 3-7 October 2005, Porto, Portugal / Jorge, Alípio Mário; Torgo, Luís; Brazdil, Pavel; Camacho, Rui; Gama, João (Eds.) 2005, pp. 285 - 296
    Online Full Text: dx.doi.org/
  • Hoffmann, Daniel
    Computergestützte molekulare Modellierung für die Suche nach neuen Wirkstoffen gegen HIV/AIDS
    In: Resistenz in der HIV-Therapie: Diagnostik und Management / Oette, Mark; Kaiser, Rolf; Häussinger, Dieter (Eds.) 2003, pp. 62 - 65
  • Hoffmann, Daniel; Schnaible, V.; Wefing, S.; Albrecht, M.; Hanisch, D.; Zimmer, R.
    A New Method for the Fast Solution of Protein-3D-Structures, combining Experiments and Bioinformatics
    In: Coupling of Biological and Electronic Systems: Proceedings of the 2nd Caesarium / 2nd Caesarium, Bonn, November 1–3, 2000 / Hoffmann, Karl-Heinz (Eds.) 2002, pp. 59 - 78
    Online Full Text: dx.doi.org/
  • Beerenwinkel, Niko; Schmidt, Barbara; Walter, Hauke; Kaiser, Rolf; Lengauer, Thomas; Hoffmann, Daniel; Korn, Klaus; Selbig, Joachim
    Identifying Drug Resistance-Associated Patterns in HIV Genotypes
    In: Computer science and biology: proceedings of the German Conference on Bioinformatics / German Conference on Bioinformatics (GCB '01), 7.-10. October 2001, Braunschweig / Wingender, Edgar (Eds.) 2001, pp. 126 - 130
  • Rabenstein, Björn; Hoffmann, Daniel; Knapp, Ernst-Walter
    Simulation of oligopeptide folding or how do residues talk
    In: Biological Physics: Third International Symposium ; Santa Fe, NM, September 1998 / Third International Symposium on Biological Physics ; September 20-24, 1998, Santa Fe, New Mexico, USA / Frauenfelder, Hans; Hummer, Gerhard; Garcia, Roderick (Eds.) 1999, pp. 54 - 68
    Online Full Text: dx.doi.org/
  • Hoffmann, Daniel; Washio, Takashi; Gessler, Katrin; Jacob, Jean-Paul
    Tackling Concrete Problems in Molecular Biophysics Using Monte Carlo and Related Methods : Glycosylation, Folding, Solvation
    In: Workshop on Monte Carlo Approach to Biopolymers and Protein Folding / Workshop on Monte Carlo Approach to Biopolymers and Protein, 3 - 5 December 1997 , Jülich, Germany / Grassberger, P.; Barkema, G.; Nadler, W. (Eds.) 1998, pp. 153 - 170
    Online Full Text
  • Hoffmann, Daniel; Knapp, E.W.
    A Monte Carlo method for simulations of protein folding with detailed protein models
    In: Perspectives on protein engineering: a comprehensive on-line access tool for Web-based resources, papers from Perspectives on Protein Engineering '96 / Perspectives on Protein Engineering Conference 5 (POPE5), 2-6 March 1996, Montpellier 1996

    • Books, Collections, Proceedings

  • Hoffmann, Daniel
    Monte Carlo Methoden zur Simulation der Langzeitdynamik von Proteinen
    In: Bioinformatik Berlin (1996) 115 Seiten