Welcome to ZMB

Welcome to ZMB

The Center of Medical Biotechnology (ZMB) is an interdisciplinary scientific center of the University of Duisburg-Essen, integrating medical research at the University Hospital and natural sciences at the Campus.

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© UME

New targets for cancer therapies Röntgen Prize for PD Dr. Johann Matschke

Congratulations: The renowned 15,000 euro Röntgen Prize of Justus Liebig University Giessen this year goes to cell biologist PD Dr. Johann Matschke from Essen University Hospital. ZMB member and radiation researcher Johann Matschke receives the prize for his research into the radiation resistance of cancer cells. He has discovered that the defense systems of tumor cells that have become resistant to radiotherapy can be impaired in such a way that the cells are again vulnerable to reactive oxygen radicals and thus to radiation, and hopes to derive new biomarkers for radiation resistance from his findings.

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© UDE

Mike Blüggel Awarded Joachim Herz Add-on Fellowship

Congratulations to Mike Blüggel on receiving the Joachim Herz Add-on Fellowship for "Innovative Tumor Treatment Project"! His project "Sundowner", explores light-controlled protein degradation using nanobody-PHOTACs in collaboration with UDE´s Faculty of Chemistry. The goal is to combine PHOTACs with nanobodies to enable targeted degradation of the apoptosis inhibitor Survivin in tumor tissue, thereby protecting healthy tissue.
The fellowship enables research stays, conference attendance, training, science communication activities, and participation in fellowship meetings.

© TS

Congrats! Funding Award for Kathrin Thedieck

[25.10.2024] For her research into the development of new therapeutic approaches for the rare disease tuberous sclerosis, Professor Kathrin Thedieck has now received the Klüh Foundation's EUR 25,000 funding prize, which is awarded to promote innovation in science and research. Kathrin Thedieck, head of the “Metabolism, Senescence and Autophagy” department at the newly founded Research Center One Health of the University Alliance Ruhr, has been supporting the tuberous sclerosis movement in Germany for many years, and not just scientifically.

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CRC1430 Guest Speaker Series

26.11.2024
Georg Winter, Center for Molecular Medicine, Austrian Academy of Sciences

Seminar program

Sex and Gender in the Life Sciences

03.12.2024
Impact of steroid hormones on affective behavior
Prof. Dr. Ulrike Krämer, University of Lübeck

Seminar program

Press Releases 2024

More ZMB Press Releases

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© WPE
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uni-due.de | Presse release

Rund sechs Millionen Euro fließen in neues Graduiertenkolleg DFG fördert Forschung zur Protonentherapie an der Universitätsallianz Ruhr

[18.11.2024] In Zukunft können Nachwuchswissenschaftler:innen im Ruhrgebiet an der Schnittstelle zwischen Physik, Chemie und Medizin promovieren und das zukunftsträchtige Themenfeld der Protonentherapie erforschen: Die Deutsche Forschungsgemeinschaft (DFG) hat die Einrichtung des Graduiertenkollegs 3043 „AMTEC-PRO“ an der TU Dortmund und der Universität Duisburg-Essen beschlossen. Sie fördert das Graduiertenkolleg (GRK) ab Oktober 2025 für zunächst fünf Jahre mit insgesamt rund sechs Millionen Euro. Sprecher des Kollegs ist Prof. Kevin Kröninger von der Fakultät Physik der TU Dortmund.

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uni-due.de | Presse release

Mitochondriale DNA-Mutationen Bremse oder Antrieb der Krebsentwicklung?

[06.11.2024] Genetische Veränderungen in der DNA der Mitochondrien spielen bei vielen erblichen Krebserkrankungen eine entscheidende Rolle. Diese Veränderungen beeinflussen auch die Entstehung und das Wachstum von schwarzem Hautkrebs, haben Forschende der Universität Duisburg-Essen und der University of Texas (USA) jetzt in Laborversuchen mit einem neu entwickelten Krebsmodell zeigen können.

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© RUB/Katja Marquard
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uni-due.de | Presse release

Ministerpräsident Hendrik Wüst MdL und NRW-Wissenschaftsministerin Ina Brandes MdL eröffnen Research Center One Health Ruhr UA Ruhr-Spitzenforschung in Gesundheit, Umwelt und Gesellschaft

[04.11.2024] Die heutige Eröffnung des Research Centers One Health Ruhr durch Ministerpräsident Hendrik Wüst MdL und NRW-Wissenschaftsministerin Ina Brandes definiert neue Maßstäbe für eine interdisziplinäre und international wettbewerbsfähige Spitzenforschung in Gesundheit, Umwelt und Gesellschaft. Der Ansatz ist neuartig: Am Research Center One Health Ruhr werden die komplexen Wechselbeziehungen zwischen menschlicher Gesundheit und Umweltgesundheit erforscht. Von den geplanten 14 Forschungsprofessuren konnten bereits acht mit international herausragenden Spitzenwissenschaftler:innen an der Universität Duisburg-Essen, der Ruhr-Universität Bochum und der TU Dortmund besetzt werden. Die drei Partner der Universitätsallianz Ruhr tragen das Research Center One Health Ruhr gemeinsam als Teil der Research Alliance Ruhr.

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© Alexander Raths - stock.adobe.com
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uni-due.de | Presse release

Blutbildende Stammzellen Warum werden schwangere Frauen nicht anämisch?

[30.10.2024] Werden vermehrt rote Blutkörperchen im Körper benötigt – beispielsweise während einer Schwangerschaft - müssen die blutbildenden Stammzellen zur Produktion angeregt werden. Wie diese Stammzellen aktiviert werden, war bisher unklar. Forschende der Medizinischen Fakultät der Universität Duisburg-Essen haben in einer kürzlich in Science veröffentlichten Studie festgestellt, dass sogenannte Retrotransposons, kleine Erbguteinheiten, die sich innerhalb des Genoms hin und her bewegen können, die Aktivierung der Stammzellen auslösen und so die Blutbildung in Gang setzen.

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© yodiyim - stock.adobe.com
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uni-due.de | Presse release

Tumorforschung bei Prostatakrebs Neue Bildgebung sagt Behandlungserfolg voraus

[30.10.2024] Ein internationales Konsortium untersucht im Zuge des Projektes ILLUMINATE, wie ein neues bildgebendes Verfahren den Behandlungserfolg für Menschen mit Prostatakrebs in fortgeschrittenem Stadium vorhersagen kann. Im Fokus steht die metabolische Magnetresonanztomographie, die chemische Prozesse im Körper besonders deutlich sichtbar macht. Dem Konsortium gehören Vertreter:innen von 15 Institutionen an, darunter Teams um Prof. Dr. Ken Herrmann und Prof. Dr. Tom Scheenen, Forscher an der Medizinischen Fakultät der Universität Duisburg-Essen. Gefördert wird ILLUMINATE von der „Innovative Health Initiative“ der Europäischen Union (EU IHI) mit rund 19 Millionen Euro, von denen 648.400 Euro nach Essen fließen. Das Projekt startet im November 2024 und läuft 54 Monate.

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© UDE/Arne Rensing
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uni-due.de | Presse release

Gottschalk-Diederich-Baedeker-Preis für Kai S. Exner Grundlagen der Energiewende

[24.10.2024] Seine Grundlagenforschung zu Elektrokatalysatoren trägt wesentlich dazu bei, die Energiewende voranzubringen: Der Theoretische Chemiker Prof. Dr. Kai S. Exner der Universität Duisburg-Essen wird in diesem Jahr mit dem Gottschalk-Diederich-Baedeker-Preis ausgezeichnet. Essens Oberbürgermeister Thomas Kufen überreichte den mit 5.000 Euro dotierten Preis.
„Die Verleihung stellt eine große Anerkennung meiner Forschung dar und unterstreicht die Bedeutung theoretischer Grundlagenforschung für die Energiewende“, sagt Exner, der als erster Theoretischer Elektrochemiker mit der seit 1984 verliehenen Auszeichnung geehrt wurde.

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ZMB Research Programs

Oncology

The concept of this research program is to understand fundamental processes in tumor biology in order to develop novel molecularly defined and rationally applied cancer treatments.

Participating researchers from biology, experimental and clinical medicine study tumors as “biological systems" and so called “neo-organs”.

A large variety of approaches, experimental systems and methodologies are in place to analyse many aspects of tumor development, growth, progression and tumor cell migration.

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Immunology, Infectious Diseases and Transplantation

The immune system responds to various pathogens including viruses and bacteria in different ways to prevent severe disease and persistence in the host. Many pathogens, however, have developed mechanisms to evade immune defence.

The molecular and cellular interactions of pathogens with the immune system are studied within this program.

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Molecular and Chemical Cell Biology

Molecular and chemical cell biology is an interdisciplinary research program connecting molecular cell biology and genetics with chemistry and structural biology. Scientists of the participating disciplines collaborate to advance the understanding of basic molecular mechanisms of important biological processes.

The analysis of regulation and deregulation of key pathways is linking basic biology with pathophysiology.

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Latest Publications

    Journal articles

  • Pozniak, Joanna; Pedri, Dennis; Landeloos, Ewout; Van Herck, Yannick; Antoranz, Asier; Vanwynsberghe, Lukas; Nowosad, Ada; Roda, Niccolò; Makhzami, Samira; Bervoets, Greet; Maciel, Lucas Ferreira; Pulido-Vicuña, Carlos Ariel; Pollaris, Lotte; Seurinck, Ruth; Zhao, Fang; Flem-Karlsen, Karine; Damsky, William; Chen, Limin; Karagianni, Despoina; Cinque, Sonia; Kint, Sam; Vandereyken, Katy; Rombaut, Benjamin; Voet, Thierry; Vernaillen, Frank; Annaert, Wim; Lambrechts, Diether; Boecxstaens, Veerle; Saeys, Yvan; van den Oord, Joost; Bosisio, Francesca; Karras, Panagiotis; Shain, A. Hunter; Bosenberg, Marcus; Leucci, Eleonora; Paschen, Annette; Rambow, Florian; Bechter, Oliver; Marine, Jean-Christophe
    A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma
    In: Cell Vol. 187 (2024) Nr. 1, pp. 166 - 183.e25
  • Huang, Jing; Jaekel, Andreas; van den Boom, Johannes; Podlesainski, David; Elnaggar, M.; Heuer-Jungemann, A.; Kaiser, Markus; Meyer, Hemmo; Saccà, Barbara
    A modular DNA origami nanocompartment for engineering a cell-free, protein unfolding and degradation pathway
    In: Nature Nanotechnology Vol. 19 (2024) Nr. 10, pp. 1521 - 1531
  • Hedtfeld, Marius; Dammers, Alicia; Koerner, Carolin; Musacchio, Andrea
    A validation strategy to assess the role of phase separation as a determinant of macromolecular localization
    In: Molecular Cell Vol. 84 (2024) Nr. 9, pp. 1783 - 1801.e7
  • Bührer, Emanuel; Kicinski, Michal; Mandala, Mario; Pe, Madeline; Long, Georgina V; Atkinson, Victoria; Blank, Christian U; Haydon, Andrew; Dalle, Stéphane; Khattak, Adnan; Carlino, Matteo S; Meshcheryakov, Andrey; Sandhu, Shahneen; Puig, Susana; Schadendorf, Dirk; Jamal, Rahima; Rutkowski, Piotr; van den Eertwegh, Alfonsus J M; Coens, Corneel; Grebennik, Dmitri; Krepler, Clemens; Robert, Caroline; Eggermont, Alexander M M
    Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054) : Long-term, health-related quality-of-life results from a double-blind, randomised, controlled, phase 3 trial
    In: The Lancet Oncology Vol. 25 (2024) Nr. 9, pp. 1202 - 1212
  • Roos, Andreas; Schmitt, Linda-Isabell; Hansmann, Christina; Hezel, Stefanie; Salmanian, Schahin; Hentschel, Andreas; Meyer, Nancy; Marina, Adela Della; Kölbel, Heike; Kleinschnitz, Christoph; Schara-Schmidt, Ulrike; Leo, Markus; Hagenacker, Tim
    Alteration of LARGE1 abundance in patients and a mouse model of 5q-associated spinal muscular atrophy
    In: Acta Neuropathologica Vol. 147 (2024) Nr. 1, 53
  • Felip, E.; Cho, B.C.; Gutiérrez, V.; Alip, A.; Besse, B.; Lu, S.; Spira, A.I.; Girard, N.; Califano, R.; Gadgeel, S.M.; Yang, J.C.-H.; Yamamoto, S.; Azuma, K.; Kim, Y.J.; Lee, K.-H.; Danchaivijitr, P.; Ferreira, C.G.; Cheng, Y.; Sendur, M.A.N.; Chang, G.-C.; Wang, C.-C.; Prabhash, K.; Shinno, Y.; Stroyakovskiy, D.; Paz-Ares, L.; Rodriguez-Cid, J.R.; Martin, C.; Campelo, M.R.G.; Hayashi, H.; Nguyen, D.; Tomasini, P.; Gottfried, M.; Dooms, C.; Passaro, A.; Schuler, Martin; Gelatti, A.C.Z.; Owen, S.; Perdrizet, K.; Ou, S.-H.I.; Curtin, J.C.; Zhang, J.; Gormley, M.; Sun, T.; Panchal, A.; Ennis, M.; Fennema, E.; Daksh, M.; Sethi, S.; Bauml, J.M.; Lee, S.-H.
    Amivantamab plus lazertinib versus osimertinib in first-line EGFR-mutant advanced non-small-cell lung cancer with biomarkers of high-risk disease : a secondary analysis from MARIPOSA
    In: Annals of Oncology Vol. 35 (2024) Nr. 9, pp. 805 - 816
  • Massoni-Badosa, Ramon; Aguilar-Fernández, Sergio; Nieto, Juan C.; Soler-Vila, Paula; Elosua-Bayes, Marc; Marchese, Domenica; Kulis, Marta; Vilas-Zornoza, Amaia; Bühler, Marco Matteo; Rashmi, Sonal; Alsinet, Clara; Caratù, Ginevra; Moutinho, Catia; Ruiz, Sara; Lorden, Patricia; Lunazzi, Giulia; Colomer, Dolors; Frigola, Gerard; Blevins, Will; Romero-Rivero, Lucia; Jiménez-Martínez, Víctor; Vidal, Anna; Mateos-Jaimez, Judith; Maiques-Diaz, Alba; Ovejero, Sara; Moreaux, Jérôme; Palomino, Sara; Gomez-Cabrero, David; Agirre, Xabier; Weniger, Marc A.; King, Hamish W.; Garner, Lucy C.; Marini, Federico; Cervera-Paz, Francisco Javier; Baptista, Peter M.; Vilaseca, Isabel; Rosales, Cecilia; Ruiz-Gaspà, Silvia; Talks, Benjamin; Sidhpura, Keval; Pascual-Reguant, Anna; Hauser, Anja E.; Haniffa, Muzlifah; Prosper, Felipe; Küppers, Ralf; Gut, Ivo Glynne; Campo, Elias; Martin-Subero, José Ignacio; Heyn, Holger
    An atlas of cells in the human tonsil
    In: Immunity Vol. 57 (2024) Nr. 2, pp. 379 - 399.e18
  • Teuber, A.; Schulz, T.; Fletcher, B.S.; Gontla, R.; Mühlenberg, Thomas; Zischinsky, M.-L.; Niggenaber, J.; Weisner, J.; Kleinbölting, S.B.; Lategahn, J.; Sievers, S.; Müller, M.P.; Bauer, Sebastian; Rauh, D.
    Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA
    In: Nature Communications Vol. 15 (2024) Nr. 1, 63
  • Prosdocimi, Elena; Carpanese, Veronica; Todesca, Luca Matteo; Varanita, Tatiana; Bachmann, Magdalena; Festa, Margherita; Bonesso, Daniele; Perez-Verdaguer, Mireia; Carrer, Andrea; Velle, Angelo; Peruzzo, Roberta; Muccioli, Silvia; Doni, Davide; Leanza, Luigi; Costantini, Paola; Stein, Frank; Rettel, Mandy; Felipe, Antonio; Edwards, Michael J.; Gulbins, Erich; Cendron, Laura; Romualdi, Chiara; Checchetto, Vanessa; Szabo, Ildiko
    BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway
    In: Science Advances Vol. 10 (2024) Nr. 36, eadn9361
  • Anker, Markus S.; Rassaf, Tienush; Zamorano, José L.; Khan, Muhammad Shahzeb; Landmesser, Ulf
    Cardiac wasting and cancer
    In: European Heart Journal Vol. 45 (2024) Nr. 34, pp. 3135 - 3137
  • Lu, I-Na; Cheung, Phyllis Fung-Yi; Heming, Michael; Thomas, Christian; Giglio, Giovanni; Leo, Markus; Erdemir, Merve; Wirth, Timo; König, Simone; Dambietz, Christine A.; Schroeter, Christina B.; Nelke, Christopher; Siveke, Jens; Ruck, Tobias; Klotz, Luisa; Haider, Carmen; Höftberger, Romana; Kleinschnitz, Christoph; Wiendl, Heinz; Hagenacker, Tim; Meyer zu Horste, Gerd
    Cell-mediated cytotoxicity within CSF and brain parenchyma in spinal muscular atrophy unaltered by nusinersen treatment
    In: Nature Communications Vol. 15 (2024) Nr. 1, 4120
  • Heinrich, Michael C.; Zhang, Xinhua; Jones, Robin L.; George, Suzanne; Serrano, César; Deng, Yanhong; Bauer, Sebastian; Cai, Shirong; Wu, Xin; Zhou, Yongjian; Tao, Kaixiong; Zheng, Zhichao; Zhang, Jun; Cui, Yuehong; Cao, Hui; Wang, Meining; Hu, Jin; Yang, Jason; Li, Jian; Shen, Lin
    Clinical Benefit of Avapritinib in KIT-Mutant Gastrointestinal Stromal Tumors : A Post Hoc Analysis of the Phase I NAVIGATOR and Phase I/II CS3007-001 Studies
    In: Clinical Cancer Research Vol. 30 (2024) Nr. 4, pp. 719 - 728
  • Dobersalske, Celia; Rauschenbach, Laurèl; Hua, Yichao; Berliner, Christoph; Steinbach, Anita; Grüneboom, Anika; Kokkaliaris, Konstantinos D.; Heiland, Dieter H.; Berger, Pia; Langer, Sarah; Tan, Chin L.; Stenzel, Martin; Landolsi, Somaya; Weber, Flora; Darkwah Oppong, Marvin; Werner, Rudolf A.; Gull, Hanah; Schröder, Thomas; Linsenmann, Thomas; Buck, Andreas K.; Gunzer, Matthias; Stuschke, Martin; Keyvani, Kathy; Forsting, Michael; Glas, Martin; Kipnis, Jonathan; Steindler, Dennis A.; Reinhardt, Hans Christian; Green, Edward W.; Platten, Michael; Tasdogan, Alpaslan; Herrmann, Ken; Rambow, Florian; Cima, Igor; Sure, Ulrich; Scheffler, Björn
    Cranioencephalic functional lymphoid units in glioblastoma
    In: Nature Medicine (2024) in press
  • Tran, Diem H.; Kim, Dohun; Kesavan, Rushendhiran; Brown, Harrison; Dey, Trishna; Soflaee, Mona Hoseini; Vu, Hieu S.; Tasdogan, Alpaslan; Guo, Jason; Bezwada, Divya; Al Saad, Houssam; Cai, Feng; Solmonson, Ashley; Rion, Halie; Chabatya, Rawand; Merchant, Salma; Manales, Nathan J.; Tcheuyap, Vanina T.; Mulkey, Megan; Mathews, Thomas P.; Brugarolas, James; Morrison, Sean J.; Zhu, Hao; DeBerardinis, Ralph J.; Hoxhaj, Gerta
    De novo and salvage purine synthesis pathways across tissues and tumors
    In: Cell Vol. 187 (2024) Nr. 14, pp. 3602 - 3618.e20
  • Arrieta-Bolaños, Esteban; van der Burg, Lars L. J.; Gedde-Dahl, Tobias; Robin, Marie; Salmenniemi, Urpu; Kröger, Nicolaus; Yakoub-Agha, Ibrahim; Huynh, Anne; Crawley, Charles; Deconinck, Eric; Bulabois, Claude Eric; Forcade, Edouard; Tholouli, Eleni; van der Hem, Joost G. K.; van Balen, Peter; Hoogenboom, Jorinde D.; de Wreede, Liesbeth C.; Malard, Florent; Ruggeri, Annalisa; Fleischhauer, Katharina
    Directionality of HLA-DP permissive mismatches improves risk prediction in HCT for acute leukemia and MDS
    In: Blood Vol. 144 (2024) Nr. 16, pp. 1747 - 1751
  • Heger, Jan-Michel; Mattlener, Julia; Schneider, Jessica; Gödel, Philipp; Sieg, Noëlle; Ullrich, Fabian; Lewis, Richard; Bucaciuc-Mracica, Teodora; Schwarz, Roland F.; Rueß, Daniel; Ruge, Maximilian I.; Montesinos-Rongen, Manuel; Deckert, Martina; Blau, Tobias; Kutsch, Nadine; Balke-Want, Hyatt; Weiss, Jonathan; Becker, Kerstin; Reinhardt, H. Christian; Hallek, Michael; Borchmann, Peter; von Tresckow, Bastian; Borchmann, Sven
    Entirely noninvasive outcome prediction in central nervous system lymphomas using circulating tumor DNA
    In: Blood Vol. 143 (2024) Nr. 6, pp. 522 - 534
  • George, Julie; Maas, Lukas; Abedpour, Nima; Cartolano, Maria; Kaiser, Laura; Fischer, Rieke N.; Scheel, Andreas H.; Weber, Jan-Philipp; Hellmich, Martin; Bosco, Graziella; Volz, Caroline; Mueller, Christian; Dahmen, Ilona; John, Felix; Alves, Cleidson Padua; Werr, Lisa; Panse, Jens Peter; Kirschner, Martin; Engel-Riedel, Walburga; Jürgens, Jessica; Stoelben, Erich; Brockmann, Michael; Grau, Stefan; Sebastian, Martin; Stratmann, Jan A.; Kern, Jens; Hummel, Horst-Dieter; Hegedüs, Balazs; Schuler, Martin; Plönes, Till; Aigner, Clemens; Elter, Thomas; Toepelt, Karin; Ko, Yon-Dschun; Kurz, Sylke; Grohé, Christian; Serke, Monika; Höpker, Katja; Hagmeyer, Lars; Doerr, Fabian; Hekmath, Khosro; Strapatsas, Judith; Kambartel, Karl-Otto; Chakupurakal, Geothy; Busch, Annette; Bauernfeind, Franz-Georg; Griesinger, Frank; Luers, Anne; Dirks, Wiebke; Wiewrodt, Rainer; Luecke, Andrea; Rodermann, Ernst; Diel, Andreas; Hagen, Volker; Severin, Kai; Ullrich, Roland T.; Reinhardt, Hans Christian; Quaas, Alexander; Bogus, Magdalena; Courts, Cornelius; Nürnberg, Peter; Becker, Kerstin; Achter, Viktor; Büttner, Reinhard; Wolf, Jürgen; Peifer, Martin; Thomas, Roman K.
    Evolutionary trajectories of small cell lung cancer under therapy
    In: Nature Vol. 627 (2024) Nr. 8005, pp. 880 - 889
  • Long, Georgina V.; Hauschild, Axel; Santinami, Mario; Kirkwood, John M.; Atkinson, Victoria; Mandala, Mario; Merelli, Barbara; Sileni, Vanna Chiarion; Nyakas, Marta; Haydon, Andrew; Dutriaux, Caroline; Robert, Caroline; Mortier, Laurent; Schachter, Jacob; Schadendorf, Dirk; Lesimple, Thierry; Plummer, Ruth; Larkin, James; Tan, Monique; Adnaik, Sachin Bajirao; Burgess, Paul; Jandoo, Tarveen; Dummer, Reinhard
    Final Results for Adjuvant Dabrafenib plus Trametinib in Stage III Melanoma
    In: The New England Journal of Medicine (2024) in press
  • Schrader, Thomas; Kubik, Stefan; Braun, Manfred
    Günter Wulff (1935 –2023) : Father of Molecular Imprinting
    In: Angewandte Chemie International Edition Vol. 63 (2024) Nr. 12, e202402244
  • Schwarz, Tatjana; Ptok, Johannes; Damagnez, Maximilian; Menne, Christopher; Alizei, Elahe Salimi; Lang-Meli, Julia; Maas, Michelle; Habermann, Daniel; Hoffmann, Daniel; Schulze zur Wiesch, Julian; Lauer, Georg; Kefalakes, Helenie; Cornberg, Markus; Kraft, Anke RM.; Gliga, Smaranda; Bock, Hans H.; Horn, Peter A.; Maini, Mala K.; Thimme, Robert; Wedemeyer, Heiner; Nattermann, Jacob; Heinemann, Falko M.; Luedde, Tom; Neumann-Haefelin, Christoph; Walker, Andreas; Timm, Jörg
    HBV shows different levels of adaptation to HLA class I-associated selection pressure correlating with markers of replication
    In: Journal of Hepatology (2024) in press
  • Gahlot, Pinki; Kravic, Bojana; Rota, Giulia; van den Boom, Johannes; Levantovsky, Sophie; Schulze, Nina; Maspero, Elena; Polo, Simona; Behrends, Christian; Meyer, Hemmo
    Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH
    In: Molecular Cell (2024) pp. 1556 - 1569.e10
  • Pleuger, Richard; Cozma, Christian; Hohoff, Simone; Denkhaus, Christian; Dudziak, Alexander; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Vetter, Ingrid R.; Westermann, Stefan
    Microtubule end-on attachment maturation regulates Mps1 association with its kinetochore receptor
    In: Current Biology Vol. 34 (2024) Nr. 11, pp. 2279 - 2293.e6
  • Schmidt, Mirko; Grethe, Christian; Recknagel, Sarah; Kipka, Gian-Marvin; Klink, Nikolas; Gersch, Malte
    N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1
    In: Angewandte Chemie International Edition Vol. 63 (2024) Nr. 12, e202318849
  • Schuler, Martin; Cuppens, Kristof; Plönes, Till; Wiesweg, Marcel; Du Pont, Bert; Hegedus, Balazs; Köster, Johannes; Mairinger, Fabian; Darwiche, Kaid; Paschen, Annette; Maes, Brigitte; Vanbockrijck, Michel; Lähnemann, David; Zhao, Fang; Hautzel, Hubertus; Theegarten, Dirk; Hartemink, Koen; Reis, Henning; Baas, Paul; Schramm, Alexander; Aigner, Clemens
    Neoadjuvant nivolumab with or without relatlimab in resectable non-small-cell lung cancer : A randomized phase 2 trial
    In: Nature Medicine Vol. 30 (2024) Nr. 6, pp. 1602 - 1611
  • Beaufort, Nathalie; Ingendahl, Linda; Merdanovic, Melisa; Schmidt, Andree; Podlesainski, David; Richter, Tim; Neumann, Thorben; Kuszner, Michael; Vetter, Ingrid R.; Stege, Patricia; Burston, Steven G.; Filipovic, Anto; Ruiz-Blanco, Yasser B.; Bravo Rodriguez, Kenny; Mieres-Perez, Joel; Beuck, Christine; Uebel, Stephan; Zobawa, Monika; Schillinger, Jasmin; Malik, Rainer; Todorov-Völgyi, Katalin; Rey, Juliana; Roberti, Annabell; Hagemeier, Birte; Wefers, Benedikt; Müller, Stephan A.; Wurst, Wolfgang; Sanchez-Garcia, Elsa; Zimmermann, Alexander; Hu, Xiao-Yu; Clausen, Tim; Huber, Robert; Lichtenthaler, Stefan F.; Schmuck, Carsten; Giese, Michael; Kaiser, Markus; Ehrmann, Michael; Dichgans, Martin
    Rational correction of pathogenic conformational defects in HTRA1
    In: Nature Communications Vol. 15 (2024) Nr. 1, 5944
  • Lim, Wei Ming; Chew, Wei-Xiang; Esposito Verza, Arianna; Pesenti, Marion; Musacchio, Andrea; Surrey, Thomas
    Regulation of minimal spindle midzone organization by mitotic kinases
    In: Nature Communications Vol. 15 (2024) Nr. 1, 9213
  • Heinrich, Michael C.; Jones, Robin L.; George, Suzanne; Gelderblom, Hans; Schöffski, Patrick; von Mehren, Margaret; Zalcberg, John R.; Kang, Yoon-Koo; Razak, Albiruni Abdul; Trent, Jonathan; Attia, Steven; Le Cesne, Axel; Siontis, Brittany L.; Goldstein, David; Boye, Kjetil; Sanchez, Cesar; Steeghs, Neeltje; Rutkowski, Piotr; Druta, Mihaela; Serrano, César; Somaiah, Neeta; Chi, Ping; Reichmann, William; Sprott, Kam; Achour, Haroun; Sherman, Matthew L.; Ruiz-Soto, Rodrigo; Blay, Jean-Yves; Bauer, Sebastian
    Ripretinib versus sunitinib in gastrointestinal stromal tumor : ctDNA biomarker analysis of the phase 3 INTRIGUE trial
    In: Nature Medicine Vol. 30 (2024) Nr. 2, pp. 498 - 506
  • Conti, Duccio; Verza, Arianna Esposito; Pesenti, Marion E.; Cmentowski, Verena; Vetter, Ingrid R.; Pan, Dongqing; Musacchio, Andrea
    Role of protein kinase PLK1 in the epigenetic maintenance of centromeres
    In: Science Vol. 385 (2024) Nr. 6713, pp. 1091 - 1097
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