DFG Consortia
ZMB Research
DFG Consortia
Coordinated Collaborative Research Centers/Transregios (CRC/TRR)
CRC 1430: Molecular Mechanisms of Cell State Transitions
Spokesperson: Prof. Dr. Hemmo Meyer, Center of Medical Biotechnology (ZMB)
Website: https://www.uni-due.de/crc1430/
| Project | ZMB Member | |
|---|---|---|
| A01: Molecular control of kinetochore microtubule interactions at the metaphase-anaphase transition | More | Prof. Dr. Stefan Westermann |
| A02: Bridging the gap between cell biology and biochemistry with artificial protein prosthetics in cell cycle transitions | More | Prof. Dr. Andrea Musacchio |
| A03: VCP/p97-cofactor complexes at the intersection of DNA repair and checkpoint control | More | Prof. Dr. Hemmo Meyer |
| A05: A molecular interface linking DNA replication with cell states of different replication competence | More | Prof. Dr. Dominik Boos |
| A06: Implications of deregulated proteostasis in cell state transitions | More | Prof. Dr. Michael Ehrmann |
| A07: Golgi stress: impacting cell cycle transitions | More | Prof. Dr. Doris Hellerschmied |
| A08: Switching of spatio-temporal Rho GTPase signal network dynamics during cell cycle phase transitions | More | Prof. Dr. Perihan Nalbant |
| A09: Targeting oncogene-induced DNA repair pathway switches | More | Prof. Dr. Christian Reinhardt |
| A11: Molecular regulation of differentiation and cell cycle in tumor-repopulating melanoma cells | More | Prof. Dr. Alexander Roesch |
| A13: IFNγ-induced cell state transition in melanoma | More | Prof. Dr. Annette Paschen |
| A14: Metastatic transition in pancreatic ductal adenocarcinoma | More | Dr. Barbara Grüner |
CRC/TRR 296: Local Control of Thyroid Hormone Action (LOCOTACT)
Spokesperson: Prof. Dr. Dagmar Führer-Sakel, University Hospital Essen
Website: https://www.uni-due.de/crctr296/
| Project | ZMB Member | |
|---|---|---|
| P08: Local TH transport and action in ischaemic brain injury | More | Prof. Dr. Dagmar Führer-Sakel Prof. Dr. Christoph Kleinschnitz |
| P10: Local TH action in acute and chronic ischaemic heart disease | More | Prof. Dr. Dagmar Führer-Sakel |
| Z03: Research Data Management (INF) | More | Prof. Dr. Dagmar Führer-Sakel |
Participation in Collaborative Research Centers/Transregios (CRC/TRR)
CRC/TRR 332: Neutrophils - Origin, Fate and Function
Spokesperson: Prof. Dr. Oliver Söhnlein, WWU Münster
Website: https://www.medizin.uni-muenster.de/sfb-trr-332/startseite.html
| Project | ZMB Member | |
|---|---|---|
| The role of Ly6g and CD177 as “eat me” signals to control neutrophil-mediated tissue destruction in stroke | More |
Prof. Dr. Matthias Gunzer
UDE Site Spokesperson Prof. Dr. Dirk Herrmann |
| Deciphering molecular links between the tumour microenvironment and functional plasticity of tumour-associated neutrophils | More | Prof. Dr. Sven Brandau |
| Impact of type I interferons on tumour-dependent granulopoiesis and neutrophil tumourigenicity | More | PD Dr. Jadwiga Jablonska-Koch Dr. Anja Hasenberg |
CRC 1439: Multilevel response to stressor increase and release in stream ecosystems (RESIST)
Spokesperson: Prof. Dr. Bernd Sures, University of Duisburg-Essen
Website: https://sfb-resist.de/
| Project | ZMB Member | |
|---|---|---|
| Direct and indirect effects of multiple stressors in freshwater ecosystems on microbial parasites and scavengers (A01) | More | Prof. Dr. Alexander Probst |
| Data management and integration (Z-INF) | More | Prof. Dr. Alexander Probst |
CRC 1399: Mechanisms of drug sensitivity and resitance in small cell lung cancer
Spokesperson: Prof. Dr. Roman Thomas, University of Cologne
Website: https://www.sfb1399.de/
| Project | ZMB Member | |
|---|---|---|
| Identification and characterization of molecular vulnerabilities in SLC (A01) | More | Prof. Dr. Christian Reinhardt |
| Project | ZMB Member | |
| Harnessing molecular vulnerabilities to promote an antitumor immune microenvironment (C02) | More | Prof. Dr. Christian Reinhardt |
CRC/TRR 247: Heterogeneous Oxidation Catalysis in the Liquid Phase – Mechanisms and Materials in Thermal, Electro-, and Photocatalysis
Spokesperson: Prof. Dr. Malte Behrens, University of Duisburg-Essen
Website: https://www.uni-due.de/sfbtrr247/
| Project | ZMB Member | |
|---|---|---|
| Pulsed Laser Post Processing of Transition Metal Oxide Nanocatalysts with Defined Defect Structure (C05) | More | Prof. Dr. Stephan Barcikowski |
CRC 1242: Non-equilibrium dynamics of condensed matter in the time domain
Spokesperson: Prof. Dr. Uwe Bovensiepen, University of Duisburg-Essen
Website: http://www.sfb1242.de/
| Project | ZMB Member | |
|---|---|---|
| Photoinduced non-equilibrium dynamics in molecular adsorbates: From ensemble to single-molecule experiments (A04) | More | Prof. Dr. Sebastian Schlücker |
Coordinated Priority Programs (SPP)
SPP 2122: Materials for Additive Manufacturing
Spokesperson: Prof. Dr. Stephan Barcikowski, University of Duisburg-Essen
Website: https://www.uni-due.de/matframe/
| Project | ZMB Member | |
|---|---|---|
| Dispersion effects of nanocomposites to improve melting and resolidification behavior during SLS with CO2 and diode lasers | More | Prof. Dr. Stepahn Barcikowski |
Participation in Priority Programs (SPP)
SPP 1926: Next Generation Optogenetics: Tool Development and Application
Spokesperson: Prof. Dr. Alexander Gottschalk, University of Frankfurt
Website: http://www.spp1926.org/
| Project | ZMB Member | |
|---|---|---|
| Optogenetic manipulation of cell contraction signal network dynamics in tumors | More | Prof. Dr. Perihan Nalbant |
SPP 1923: Innate Sensing and Restriction of Retroviruses
Spokesperson: Prof. Dr. Oliver Fackler, University Hospital Heidelberg
Website: https://spp1923.de/
| Project | ZMB Member | |
|---|---|---|
| Regulation of the induction of IFNα subtypes during HIV infection | More | Prof. Dr. Ulf Dittmer Dr. Kathrin Sutter |
Coordinated Research Units (FOR)
FOR 2879: ImmunoStroke: From immune cells to stroke recovery
Spokesperson: Prof. Dr. Christoph Kleinschnitz, University Hospital Essen
Website: https://gepris.dfg.de/gepris/projekt/405358801
| Project | ZMB Member | |
|---|---|---|
| ImmunoStroke: From Immune cells to stroke recovery Kallikrein-kinin system-mediated thrombo-inflammation as a novel target to improve long-term stroke recovery | More | Prof. Dr. Dirk M. Hermann |
| ImmunoStroke: From Immune Cells to Stroke Recovery Immune responses controlling post-stroke angiogenesis and microvascular integrity | More | Prof. Dr. Matthias Gunzer Prof. Dr. Dirk M. Hermann |
| The role of T cells in exercise-induced recovery after stroke | More | Prof. Dr. Wiebke Hansen |
Participation in Research Units (FOR)
FOR 2800: Chromosome Instability - Cross-talk of DNA replication stress and mitotic dysfunction
Spokesperson: Prof. Dr. Holger Bastians, Georg-August-Universität Göttingen
Website: https://gepris.dfg.de/gepris/projekt/395736209
| Project | ZMB Member | |
|---|---|---|
| Mutual impact of replication origin firing regulation and mitotic chromosome segregation | More | Prof. Dr. Dominik Boos |
FOR 2816: The Autotrophy-Heterotrophy Switch in Cyanobacteria: Coherent Decision-Making at Multiple Regulatory Layers
Spokesperson: Prof. Dr. Jörg Karl Forchhammer, Eberhard Karls University Tübingen
Website: https://gepris.dfg.de/gepris/projekt/397695561
| Project | ZMB Member | |
|---|---|---|
| Unraveling the cyanobacterial carbon switch and its regulation using enzyme kinetic analyses and mathematical modeling | More | Prof. Dr. Bettina Siebers |
FOR 2407: Exploring Articular Cartilage and Subchondral Bone Degeneration and Regeneration in Osteoarthritis (ExCarBon)
Spokesperson: Prof. Dr. Susanne Grässel, University of Regensburg
Website: https://www.excarbon.com/
| Project | ZMB Member | |
|---|---|---|
| Interaction of heparan sulfate and integrin signaling in maintaining the articular cartilage | More | Prof. Dr. Andrea Vortkamp Prof. Dr. Daniel Hoffmann Prof. Dr. Perihan Nalbant |
Coordinated Clinical Research Units (KFO)
KFO 337: Phenotypic Therapy and Immune Escape in Cancer (PhenoTImE)
Spokesperson: Prof. Dr. Dirk Schadendorf, University Hospital Essen
Website: https://www.uni-due.de/phenotime
| Project | ZMB Member | |
|---|---|---|
| Epigenetic-metabolic (‘epi-metabolic’) reprograming as a universal survival strategy in therapy-resistant tumor cell phenotypes | More | Prof. Dr. Alexander Rösch |
| Unraveling the phenotypic coevolution of melanoma cells and neutrophils fostering metastasis and therapy resistance | More | Prof. Dr. Matthias Gunzer Prof. Dr. Iris Helfrich |
| Translational validation of genetic and gene expression networks determining the phenotypic switch and therapy resistance of tumor cells | More | Prof. Dr. Dirk Schadendorf |
| Defining the role of CIITA in tumor cell-intrinsic and CD4+ T cell-induced phenotype switching and therapy resistance | More | Prof. Dr. Annette Paschen |
| Identification of regulators of therapy-induced epithelial mesenchymal plasticity in pancreatic cancer | More | Prof. Dr. Jens Siveke |
| Impact of the PI3K/AKT signaling pathway on epigenetic circuitry to generate immune and targeted therapy resistant melanoma phenotypes | More | Prof. Dr. Jürgen C. Becker |