ZMB Member Matthias Gunzer
ZMB Member
Matthias Gunzer
Next ZMB-Member
Prof. Dr. Matthias Gunzer
Director of:
Institute of Experimental Immunology & ImagingCenter of Medical Biotechnology (ZMB)
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen
University Hospital Essen
Hufelandstr. 55
45122 Essen
- +49 201 183 6640
- Website
- Selected Publications
- Publication Metrics
- ZMB Research Program
Immunology, Infectious Diseases and Transplantation
Research Overview
The research interest of my group is to characterize the dynamics of immune cell behaviour, their motility and migratory pattern as well as formation of cell-cell interaction within the course of the immune response in vivo. My lab employs a wide range of specialized imaging technologies by which we investigate a number of projects how immune cells function in vivo in important organs such as the lymph node, the bone marrow, the brain and the lung.
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Selected Publications
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Cranioencephalic functional lymphoid units in glioblastomaIn: Nature Medicine (2024) in pressOnline Full Text: dx.doi.org/ (Open Access)
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ComplexEye : a multi-lens array microscope for high-throughput embedded immune cell migration analysisIn: Nature Communications Vol. 14 (2023) Nr. 1, 8103Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Immunotherapy-induced cytotoxic T follicular helper cells reduce numbers of retrovirus-infected reservoir cells in B cell folliclesIn: PLoS Pathogens Vol. 19 (2023) Nr. 10, e1011725Online Full Text: dx.doi.org/ (Open Access)
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Imaging innate immunity*In: Immunological Reviews Vol. 306 (2022) Nr. 1, pp. 293 - 303Online Full Text: dx.doi.org/ (Open Access)
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The alarmin interleukin-1α triggers secondary degeneration through reactive astrocytes and endothelium after spinal cord injuryIn: Nature Communications Vol. 13 (2022) Nr. 1, 5786Online Full Text: dx.doi.org/ (Open Access)
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Antibody-guided in vivo imaging of Aspergillus fumigatus lung infections during antifungal azole treatmentIn: Nature Communications Vol. 12 (2021) Nr. 1, pp. 1707Online Full Text: dx.doi.org/ (Open Access)
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Neutrophils self-limit swarming to contain bacterial growth in vivoIn: Science Vol. 372 (2021) Nr. 6548,Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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SOCS-1 inhibition of type i interferon restrains Staphylococcus aureus skin host defenseIn: PLoS Pathogens Vol. 17 (2021) Nr. 3, pp. 1009387Online Full Text: dx.doi.org/ (Open Access)
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Durable and controlled depletion of neutrophils in miceIn: Nature Communications Vol. 11 (2020) pp. 2762Online Full Text: dx.doi.org/ (Open Access)
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Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signalingIn: Nature Communications Vol. 11 (2020) Nr. 1, pp. 3547Online Full Text: dx.doi.org/ (Open Access)
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Multicolor two-photon imaging of in vivo cellular pathophysiology upon influenza virus infection using the two-photon IMPRESSIn: Nature Protocols Vol. 15 (2020) pp. 1041 - 1065Online Full Text: dx.doi.org/ (Open Access)
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Non-classical monocyte homing to the gut via α4β7 integrin mediates macrophage-dependent intestinal wound healingIn: Gut Vol. 69 (2020) pp. 252 - 263Online Full Text: dx.doi.org/
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STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosisIn: Gut Vol. 69 (2020) Nr. 7, pp. 1269 - 1282Online Full Text: dx.doi.org/
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A network of trans-cortical capillaries as mainstay for blood circulation in long bonesIn: Nature Metabolism Vol. 1 (2019) Nr. 2, pp. 236 - 250Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal CancerIn: Immunity Vol. 50 (2019) Nr. 1, pp. 166 - 180.e7Online Full Text: dx.doi.org/ (Open Access)
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Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and responseIn: Nature Communications Vol. 10 (2019) Nr. 1, pp. 2312Online Full Text: dx.doi.org/ (Open Access)
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Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and MetastasisIn: Cancer Cell Vol. 36 (2019) Nr. 3, pp. 319 - 336.e7Online Full Text: dx.doi.org/ (Open Access)
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Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell deathIn: Nature Vol. 569 (2019) Nr. 7755, pp. 236 - 240Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Microglial cell loss after ischemic stroke favors brain neutrophil accumulationIn: Acta Neuropathologica Vol. 137 (2019) Nr. 2, pp. 321 - 341Online Full Text: dx.doi.org/ (Open Access)
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Next-generation imaging of the skeletal system and its blood supplyIn: Nature Reviews Rheumatology Vol. 15 (2019) Nr. 9, pp. 533 - 549Online Full Text: dx.doi.org/
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Publisher Correction: Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and responseIn: Nature Communications Vol. 10 (2019) Nr. 1, pp. 2768Online Full Text: dx.doi.org/ (Open Access)
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A systematic electron microscopic study on the uptake of barium sulphate nano-, submicro-, microparticles by bone marrow-derived phagocytosing cellsIn: Acta Biomaterialia Vol. 80 (2018) pp. 352 - 363Online Full Text: dx.doi.org/
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Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunityIn: Nature Immunology Vol. 19 (2018) Nr. 12, pp. 1341 - 1351Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Escaping the traps of your own huntersIn: Science Vol. 358 (2017) Nr. 6367, pp. 1126 - 1127Online Full Text: dx.doi.org/
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Irf4-dependent CD103+CD11b+ dendritic cells and the intestinal microbiome regulate monocyte and macrophage activation and intestinal peristalsis in postoperative ileusIn: Gut Vol. 66 (2017) Nr. 12, pp. 2110 - 2120Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Three-Dimensional Cross-Sectional Light-Sheet Microscopy Imaging of the Inflamed Mouse GutIn: Gastroenterology Vol. 153 (2017) Nr. 4, pp. 898 - 900Online Full Text: dx.doi.org/
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Visualizing the function and fate of neutrophils in sterile injury and repairIn: Science Vol. 358 (2017) Nr. 6359, pp. 111 - 116Online Full Text: dx.doi.org/
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Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental strokeIn: Acta Neuropathologica Vol. 129 (2015) Nr. 2, pp. 259 - 277Online Full Text: dx.doi.org/
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Traps and hyper inflammation - new ways that neutrophils promote or hinder survivalIn: British Journal of Haematology Vol. 164 (2014) Nr. 2, pp. 189 - 199Online Full Text: dx.doi.org/
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A role for LFA-1 in delaying T-lymphocyte egress from lymph nodesIn: The EMBO Journal Vol. 32 (2013) Nr. 6, pp. 829 - 843Online Full Text: dx.doi.org/
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Cellular immune reactions in the lungIn: Immunological Reviews Vol. 251 (2013) Nr. 1, pp. 189 - 214Online Full Text: dx.doi.org/
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Mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammationIn: Blood Vol. 121 (2013) Nr. 24, pp. 4930 - 4937Online Full Text: dx.doi.org/
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Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitorsIn: Blood Vol. 119 (2012) Nr. 22, pp. 5144 - 5154Online Full Text: dx.doi.org/
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Vaccine adjuvants : Tailor-made mast-cell granulesIn: Nature Materials Vol. 11 (2012) Nr. 3, pp. 181 - 182Online Full Text: dx.doi.org/
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G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligandsIn: Blood Vol. 117 (2011) Nr. 16, pp. 4349 - 4357Online Full Text: dx.doi.org/
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Mast Cells Are Key Promoters of Contact Allergy that Mediate the Adjuvant Effects of HaptensIn: Immunity Vol. 34 (2011) Nr. 6, pp. 973 - 984Online Full Text: dx.doi.org/ (Open Access)
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Immune synapse formation determines interaction forces between T cells and antigen-presenting cells measured by atomic force microscopyIn: Proceedings of the National Academy of Sciences of the United States of America Vol. 107 (2010) Nr. 5, pp. 2373Online Full Text: dx.doi.org/
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Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilizationIn: Nature Medicine Vol. 16 (2010) Nr. 10, pp. 1141 - 1146Online Full Text: dx.doi.org/
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Production of extracellular traps against Aspergillus fumigatus in vitro and in infected lung tissue is dependent on invading neutrophils and influenced by hydrophobin RodAIn: PLoS Pathogens Vol. 6 (2010) Nr. 4, pp. e1000873Online Full Text: dx.doi.org/
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Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturationIn: Immunity Vol. 33 (2010) Nr. 1, pp. 84 - 95Online Full Text: dx.doi.org/
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Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bonesIn: Blood Vol. 114 (2009) Nr. 2, pp. 290 - 298Online Full Text: dx.doi.org/ (Open Access)
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Guanine Nucleotide-Binding Proteins of the G₁₂ Family Shape Immune Functions by Controlling CD4⁺ T Cell Adhesiveness and MotilityIn: Immunity Vol. 30 (2009) Nr. 5, pp. 708 - 720Online Full Text: dx.doi.org/ (Open Access)
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Intravital two-photon microscopy : Focus on speed and time resolved imaging modalitiesIn: Immunological Reviews Vol. 221 (2008) Nr. 1, pp. 7 - 25Online Full Text: dx.doi.org/
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Environmental dimensionality controls the interaction of phagocytes with the pathogenic fungi Aspergillus fumigatus and Candida albicansIn: PLoS Pathogens Vol. 3 (2007) Nr. 2, pp. 0138 - 0151Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Naive B cells generate regulatory T cells in the presence of a mature immunologic synapseIn: Blood Vol. 110 (2007) Nr. 5, pp. 1519 - 1529Online Full Text: dx.doi.org/
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The molecular makeup and function of regulatory and effector synapsesIn: Immunological Reviews Vol. 218 (2007) Nr. 1, pp. 165 - 177Online Full Text: dx.doi.org/
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Systemic administration of a TLR7 ligand leads to transient immune incompetence due to peripheral-blood leukocyte depletionIn: Blood Vol. 106 (2005) Nr. 7, pp. 2424 - 2432Online Full Text: dx.doi.org/
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A spectrum of biophysical interaction modes between T cells and different antigen-presenting cells during priming in 3-D collagen and in vivoIn: Blood Vol. 104 (2004) Nr. 9, pp. 2801 - 2809Online Full Text: dx.doi.org/
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Molecular and functional analysis of Shiga toxin-induced response patterns in human vascular endothelial cellsIn: Blood Vol. 102 (2003) Nr. 4, pp. 1323 - 1332Online Full Text: dx.doi.org/
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Antigen presentation in extracellular matrix : Interactions of T cells with dendritic cells are dynamic, short lived, and sequentialIn: Immunity Vol. 13 (2000) Nr. 3, pp. 323 - 332Online Full Text: dx.doi.org/ (Open Access)