Welcome to ZMB

Welcome to ZMB

The Center of Medical Biotechnology (ZMB) is an interdisciplinary scientific center of the University of Duisburg-Essen, integrating medical research at the University Hospital and natural sciences at the Campus.

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© UME

New targets for cancer therapies Röntgen Prize for PD Dr. Johann Matschke

Congratulations: The renowned 15,000 euro Röntgen Prize of Justus Liebig University Giessen this year goes to cell biologist PD Dr. Johann Matschke from Essen University Hospital. ZMB member and radiation researcher Johann Matschke receives the prize for his research into the radiation resistance of cancer cells. He has discovered that the defense systems of tumor cells that have become resistant to radiotherapy can be impaired in such a way that the cells are again vulnerable to reactive oxygen radicals and thus to radiation, and hopes to derive new biomarkers for radiation resistance from his findings.

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Mike Blüggel Awarded Joachim Herz Add-on Fellowship

Congratulations to Mike Blüggel on receiving the Joachim Herz Add-on Fellowship for "Innovative Tumor Treatment Project"! His project "Sundowner", explores light-controlled protein degradation using nanobody-PHOTACs in collaboration with UDE´s Faculty of Chemistry. The goal is to combine PHOTACs with nanobodies to enable targeted degradation of the apoptosis inhibitor Survivin in tumor tissue, thereby protecting healthy tissue.
The fellowship enables research stays, conference attendance, training, science communication activities, and participation in fellowship meetings.

© TS

Congrats! Funding Award for Kathrin Thedieck

[25.10.2024] For her research into the development of new therapeutic approaches for the rare disease tuberous sclerosis, Professor Kathrin Thedieck has now received the Klüh Foundation's EUR 25,000 funding prize, which is awarded to promote innovation in science and research. Kathrin Thedieck, head of the “Metabolism, Senescence and Autophagy” department at the newly founded Research Center One Health of the University Alliance Ruhr, has been supporting the tuberous sclerosis movement in Germany for many years, and not just scientifically.

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© jannoon028/Freepik

CRC1430 Guest Speaker Series

28.01.2025
Sascha Martens, Vienna BioCenter (VBC), Max Perutz Labs, University of Vienna

18.02.2025
Hana Polasek-Sedlackova, Institute of Biophysics, Czech Academy of Sciences

28.02.2025
Helge Ewers, Institute for Chemistry and Biochemistry, Freie Universität Berlin

Seminar program

Press Releases 2024/2025

More ZMB Press Releases

Kathrin Thedieck portrait
© UDE/Bettina Engel-Albustin
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uni-due.de | Presse release

UA Ruhr Berufung: Kathrin Thedieck Stoffwechselsignale eröffnen neue Ansätze für Krebsforschung und seltene Erkrankungen

[07.01.2025] Stress gilt allgemein als ungesund. Wie er sich auf den menschlichen Stoffwechsel auswirkt untersucht Prof. Dr. Kathrin Thedieck, neu berufene Professorin für Metabolismus, Seneszenz und Autophagie an der Fakultät für Medizin der UDE. Dafür forscht sie am Research Center One Health der Universitätsallianz Ruhr zur Kontrolle des Stoffwechsels in Tumorzellen.
ZMB Member: Prof. Dr. Kathrin Thedieck

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© UDE/AG Knauer
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uni-due.de | Presse release

Wilhelm Sander-Stiftung fördert Vorhaben Photo-dynamische Liganden für die Onkologie

[06.01.2025] Ein kleines Protein namens Survivin hilft Tumorzellen dabei, den gängigen Behandlungsmethoden zu entkommen, und sichert so deren Überleben. Die Molekularbiologin Prof. Dr. Shirley Knauer und Chemiker Prof. Dr. Michael Giese von der Universität Duisburg-Essen wollen nun dynamische, durch Licht schaltbare Liganden-Systeme als neuartige Survivin-Inhibitoren entwickeln. Ihr Vorhaben fördert die Wilhelm Sander-Stiftung mit knapp 190.000 Euro für zwei Jahre.
ZMB Member: Prof. Dr. Shirley Knauer

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© UDE/Exner Group
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uni-due.de | Presse release

Oxygen and chlorine evolution without noble metals Electrode potential transforms surfaces

[17.12.2024] They are highly selective and can be easily separated from the reaction mixture: single-atom catalysts combine the advantages of homogeneous and heterogeneous catalysis. Until now, their production has generally been associated with precious metals that are anchored to a solid substrate. Researchers led by the University of Duisburg-Essen have now shown that such structures can also be formed electrochemically – independently and without noble metals. Their findings, published in the scientific journal JACS*, open up new avenues for a simpler, more sustainable production of catalytically active materials.
ZMB Member: Prof. Dr. Kai Exner

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© UDE/Anzhela Galstyan
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uni-due.de | Presse release

Antibakterielle Nanomaterialien Aktive Zentren bei Wasserdesinfektion sichtbar gemacht

[11.12.2024] Neue Methoden im Kampf gegen Bakterien sind gefragter denn je. Ein vielversprechender Weg führt über Nanomaterialien, die unter Lichteinfluss Sauerstoffradikale freisetzen und Mikroorganismen gezielt abtöten. Eine Herausforderung bei der Entwicklung solcher Materialien besteht jedoch darin, die auf molekularer Ebene beobachteten Eigenschaften auf das gesamte Material zu übertragen. Mehr Licht ins Dunkel bringt nun eine Studie der Universität Duisburg-Essen in der Fachzeitschrift Angewandte Chemie*: Das Team um Juniorprofessorin Dr. Anzhela Galstyan machte erstmals die aktiven Zentren im Fluoreszenzlebensdauer-Mikroskop sichtbar und stellt so Zusammenhänge zwischen Aktivität und Materialeigenschaften her.
ZMB Member: Prof. Dr. Anzhela Galstyan

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© escapejaja - stock.adobe.com
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uni-due.de | Presse release

"Highly Cited Researchers 2024" Sieben UDE-Forschende werden häufig zitiert

[05.12.2024] Täglich sammeln Wissenschaftler:innen der UDE wichtige Erkenntnisse und veröffentlichen neue Forschungsergebnisse für ihre Disziplinen. Sieben von ihnen gehören zu den "Highly Cited Researchers 2024". Sie zählen damit zu den ein Prozent der weltweit einflussreichsten Wissenschaftler:innen. Die renommierte Liste von Clarivate würdigt Arbeiten, die weltweit besonders häufig zitiert werden und somit maßgeblichen Einfluss auf das jeweilige Fachgebiet und/ oder über alle Disziplinen hinweg haben.
ZMB Member: Prof. Dr. Alexander Probst
ZMB Member: Prof. Dr. Dirk Schadendorf

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© TUDO, RUB, UDE
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UA Ruhr 27 neue Forschungsprofessuren besetzt

[02.12.2024] Die vier Research Center sowie das College der Universitätsallianz Ruhr (UA Ruhr) bilden ein neues forschungsstarkes Zentrum in der Wissenschaftsmetropole Ruhrgebiet. Bereits 27 internationale Spitzenwissenschaftler:innen haben sich für eine Zukunft in der UA Ruhr und damit an einer der drei Partneruniversitäten, der Ruhr-Universität Bochum, der Technischen Universität Dortmund oder der Universität Duisburg-Essen, entschieden. Insgesamt werden mehr als 50 neue Forschungsprofessuren innerhalb der Center und des College geschaffen.

ZMB Member: Prof. Dr. Dana Branzei
ZMB Member: Prof. Dr. Alexander Probst

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ZMB Research Programs

Oncology

The concept of this research program is to understand fundamental processes in tumor biology in order to develop novel molecularly defined and rationally applied cancer treatments.

Participating researchers from biology, experimental and clinical medicine study tumors as “biological systems" and so called “neo-organs”.

A large variety of approaches, experimental systems and methodologies are in place to analyse many aspects of tumor development, growth, progression and tumor cell migration.

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Immunology, Infectious Diseases and Transplantation

The immune system responds to various pathogens including viruses and bacteria in different ways to prevent severe disease and persistence in the host. Many pathogens, however, have developed mechanisms to evade immune defence.

The molecular and cellular interactions of pathogens with the immune system are studied within this program.

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Molecular and Chemical Cell Biology

Molecular and chemical cell biology is an interdisciplinary research program connecting molecular cell biology and genetics with chemistry and structural biology. Scientists of the participating disciplines collaborate to advance the understanding of basic molecular mechanisms of important biological processes.

The analysis of regulation and deregulation of key pathways is linking basic biology with pathophysiology.

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Latest Publications

    Journal articles

  • Pozniak, Joanna; Pedri, Dennis; Landeloos, Ewout; Van Herck, Yannick; Antoranz, Asier; Vanwynsberghe, Lukas; Nowosad, Ada; Roda, Niccolò; Makhzami, Samira; Bervoets, Greet; Maciel, Lucas Ferreira; Pulido-Vicuña, Carlos Ariel; Pollaris, Lotte; Seurinck, Rut et al.
    A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma
    In: Cell Vol. 187 (2024) Nr. 1, pp. 166 - 183.e25
  • Huang, Jing; Jaekel, Andreas; van den Boom, Johannes; Podlesainski, David; Elnaggar, M.; Heuer-Jungemann, A.; Kaiser, Markus; Meyer, Hemmo; Saccà, Barbara.
    A modular DNA origami nanocompartment for engineering a cell-free, protein unfolding and degradation pathway
    In: Nature Nanotechnology Vol. 19 (2024) Nr. 10, pp. 1521 - 1531
  • Hedtfeld, Marius; Dammers, Alicia; Koerner, Carolin; Musacchio, Andrea.
    A validation strategy to assess the role of phase separation as a determinant of macromolecular localization
    In: Molecular Cell Vol. 84 (2024) Nr. 9, pp. 1783 - 1801.e7
  • Bührer, Emanuel; Kicinski, Michal; Mandala, Mario; Pe, Madeline; Long, Georgina V; Atkinson, Victoria; Blank, Christian U; Haydon, Andrew; Dalle, Stéphane; Khattak, Adnan; Carlino, Matteo S; Meshcheryakov, Andrey; Sandhu, Shahneen; Puig, Susana; Schadendor et al.
    Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054) : Long-term, health-related quality-of-life results from a double-blind, randomised, controlled, phase 3 trial
    In: The Lancet Oncology Vol. 25 (2024) Nr. 9, pp. 1202 - 1212
  • Roos, Andreas; Schmitt, Linda-Isabell; Hansmann, Christina; Hezel, Stefanie; Salmanian, Schahin; Hentschel, Andreas; Meyer, Nancy; Della Marina, Adela; Kölbel, Heike; Kleinschnitz, Christoph; Schara-Schmidt, Ulrike; Leo, Markus; Hagenacker, Tim.
    Alteration of LARGE1 abundance in patients and a mouse model of 5q-associated spinal muscular atrophy
    In: Acta Neuropathologica Vol. 147 (2024) Nr. 1, 53
  • Felip, E.; Cho, B.C.; Gutiérrez, V.; Alip, A.; Besse, B.; Lu, S.; Spira, A.I.; Girard, N.; Califano, R.; Gadgeel, S.M.; Yang, J.C.-H.; Yamamoto, S.; Azuma, K.; Kim, Y.J.; Lee, K.-H.; Danchaivijitr, P.; Ferreira, C.G.; Cheng, Y.; Sendur, M.A.N.; Chang, G.-C et al.
    Amivantamab plus lazertinib versus osimertinib in first-line EGFR-mutant advanced non-small-cell lung cancer with biomarkers of high-risk disease : a secondary analysis from MARIPOSA
    In: Annals of Oncology Vol. 35 (2024) Nr. 9, pp. 805 - 816
  • Massoni-Badosa, Ramon; Aguilar-Fernández, Sergio; Nieto, Juan C.; Soler-Vila, Paula; Elosua-Bayes, Marc; Marchese, Domenica; Kulis, Marta; Vilas-Zornoza, Amaia; Bühler, Marco Matteo; Rashmi, Sonal; Alsinet, Clara; Caratù, Ginevra; Moutinho, Catia; Ruiz, Sa et al.
    An atlas of cells in the human tonsil
    In: Immunity Vol. 57 (2024) Nr. 2, pp. 379 - 399.e18
  • Teuber, A.; Schulz, T.; Fletcher, B.S.; Gontla, R.; Mühlenberg, Thomas; Zischinsky, M.-L.; Niggenaber, J.; Weisner, J.; Kleinbölting, S.B.; Lategahn, J.; Sievers, S.; Müller, M.P.; Bauer, Sebastian; Rauh, D.
    Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA
    In: Nature Communications Vol. 15 (2024) Nr. 1, 63
  • Prosdocimi, Elena; Carpanese, Veronica; Todesca, Luca Matteo; Varanita, Tatiana; Bachmann, Magdalena; Festa, Margherita; Bonesso, Daniele; Perez-Verdaguer, Mireia; Carrer, Andrea; Velle, Angelo; Peruzzo, Roberta; Muccioli, Silvia; Doni, Davide; Leanza, Lui et al.
    BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway
    In: Science Advances Vol. 10 (2024) Nr. 36, eadn9361
  • Wu, Tong; Dhaka, Kapil; Luo, Mengjia; Wang, Bingqing; Wang, Meng; Xi, Shibo; Zhang, Mingsheng; Huang, Fuqiang; Exner, Kai S.; Lum, Yanwei.
    CCooperative Active Sites on Ag2Pt3TiS6 for Enhanced Low-Temperature Ammonia Fuel Cell Electrocatalysis
    In: Angewandte Chemie International Edition (2024) e202418691 in press
  • Anker, Markus S.; Rassaf, Tienush; Zamorano, José L.; Khan, Muhammad Shahzeb; Landmesser, Ulf.
    Cardiac wasting and cancer
    In: European Heart Journal Vol. 45 (2024) Nr. 34, pp. 3135 - 3137
  • Lu, I-Na; Cheung, Phyllis Fung-Yi; Heming, Michael; Thomas, Christian; Giglio, Giovanni; Leo, Markus; Erdemir, Merve; Wirth, Timo; König, Simone; Dambietz, Christine A.; Schroeter, Christina B.; Nelke, Christopher; Siveke, Jens; Ruck, Tobias; Klotz, Luisa; et al.
    Cell-mediated cytotoxicity within CSF and brain parenchyma in spinal muscular atrophy unaltered by nusinersen treatment
    In: Nature Communications Vol. 15 (2024) Nr. 1, 4120
  • Heinrich, Michael C.; Zhang, Xinhua; Jones, Robin L.; George, Suzanne; Serrano, César; Deng, Yanhong; Bauer, Sebastian; Cai, Shirong; Wu, Xin; Zhou, Yongjian; Tao, Kaixiong; Zheng, Zhichao; Zhang, Jun; Cui, Yuehong; Cao, Hui; Wang, Meining; Hu, Jin; Yang, et al.
    Clinical Benefit of Avapritinib in KIT-Mutant Gastrointestinal Stromal Tumors : A Post Hoc Analysis of the Phase I NAVIGATOR and Phase I/II CS3007-001 Studies
    In: Clinical Cancer Research Vol. 30 (2024) Nr. 4, pp. 719 - 728
  • Mavrakis, E; Vlachopoulou, D V; Bohnen, J B; Rudolph, I R; Jungen, Christiane; Rattka, M R; Mathew, Shibu; Rassaf, Tienush.
    Comparison of pulsed field ablation versus cryoballon and radiofrequency ablation for pulmonary vein isolation in atrial fibrillation patients with heart failure
    In: European Heart Journal Vol. 45 (2024) Nr. Supplement_1,
  • Dobersalske, Celia; Rauschenbach, Laurèl; Hua, Yichao; Berliner, Christoph; Steinbach, Anita; Grüneboom, Anika; Kokkaliaris, Konstantinos D.; Heiland, Dieter H.; Berger, Pia; Langer, Sarah; Tan, Chin L.; Stenzel, Martin; Landolsi, Somaya; Weber, Flora; Dar et al.
    Cranioencephalic functional lymphoid units in glioblastoma
    In: Nature Medicine (2024) in press
  • Tran, Diem H.; Kim, Dohun; Kesavan, Rushendhiran; Brown, Harrison; Dey, Trishna; Soflaee, Mona Hoseini; Vu, Hieu S.; Tasdogan, Alpaslan; Guo, Jason; Bezwada, Divya; Al Saad, Houssam; Cai, Feng; Solmonson, Ashley; Rion, Halie; Chabatya, Rawand; Merchant, Sa et al.
    De novo and salvage purine synthesis pathways across tissues and tumors
    In: Cell Vol. 187 (2024) Nr. 14, pp. 3602 - 3618.e20
  • Veghini, Lisa; Pasini, Davide; Fang, Rui; Delfino, Pietro; Filippini, Dea; Neander, Christian; Vicentini, Caterina; Fiorini, Elena; Lupo, Francesca; D'Agosto, Sabrina L.; Carbone, Carmine; Agostini, Antonio; Piro, Geny; Rosa, Diego; Bevere, Michele; Markus et al.
    Differential activity of MAPK signalling defines fibroblast subtypes in pancreatic cancer
    In: Nature Communications Vol. 15 (2024) Nr. 1, 10534
  • Arrieta-Bolaños, Esteban; van der Burg, Lars L. J.; Gedde-Dahl, Tobias; Robin, Marie; Salmenniemi, Urpu; Kröger, Nicolaus; Yakoub-Agha, Ibrahim; Huynh, Anne; Crawley, Charles; Deconinck, Eric; Bulabois, Claude Eric; Forcade, Edouard; Tholouli, Eleni; van d et al.
    Directionality of HLA-DP permissive mismatches improves risk prediction in HCT for acute leukemia and MDS
    In: Blood Vol. 144 (2024) Nr. 16, pp. 1747 - 1751
  • Heger, Jan-Michel; Mattlener, Julia; Schneider, Jessica; Gödel, Philipp; Sieg, Noëlle; Ullrich, Fabian; Lewis, Richard; Bucaciuc-Mracica, Teodora; Schwarz, Roland F.; Rueß, Daniel; Ruge, Maximilian I.; Montesinos-Rongen, Manuel; Deckert, Martina; Blau, Tob et al.
    Entirely noninvasive outcome prediction in central nervous system lymphomas using circulating tumor DNA
    In: Blood Vol. 143 (2024) Nr. 6, pp. 522 - 534
  • George, Julie; Maas, Lukas; Abedpour, Nima; Cartolano, Maria; Kaiser, Laura; Fischer, Rieke N.; Scheel, Andreas H.; Weber, Jan-Philipp; Hellmich, Martin; Bosco, Graziella; Volz, Caroline; Mueller, Christian; Dahmen, Ilona; John, Felix; Alves, Cleidson Padu et al.
    Evolutionary trajectories of small cell lung cancer under therapy
    In: Nature Vol. 627 (2024) Nr. 8005, pp. 880 - 889
  • Long, Georgina V.; Hauschild, Axel; Santinami, Mario; Kirkwood, John M.; Atkinson, Victoria; Mandala, Mario; Merelli, Barbara; Sileni, Vanna Chiarion; Nyakas, Marta; Haydon, Andrew; Dutriaux, Caroline; Robert, Caroline; Mortier, Laurent; Schachter, Jacob; et al.
    Final Results for Adjuvant Dabrafenib plus Trametinib in Stage III Melanoma
    In: The New England Journal of Medicine Vol. 7 (2024) Nr. 391, pp. 1709 - 1720
  • Giuranna, Johanna; Zheng, Yiran; Brandt, Matthäus; Jall, Sigrid; Mukherjee, Amrita; Shankhwar, Soni; Renner, Simone; Kurapati, Nirup Kumar; May, Caroline; Peters, Triinu; Herpertz-Dahlmann, Beate; Seitz, Jochen; de Zwaan, Martina; Herzog, Wolfgang; Ehrlich et al.
    Genetic and functional analyses of CTBP2 in anorexia nervosa and body weight regulation
    In: Molecular Psychiatry (2024) in press
  • Tarantino, Giuseppe; Ricker, Cora A.; Wang, Annette; Ge, William; Aprati, Tyler J.; Huang, Amy Y.; Madha, Shariq; Chen, Jiajia; Shi, Yingxiao; Glettig, Marc; Feng, Catherine H.; Frederick, Dennie T.; Freeman, Samuel; Holovatska, Marta M.; Manos, Michael P. et al.
    Genomic heterogeneity and ploidy identify patients with intrinsic resistance to PD-1 blockade in metastatic melanoma
    In: Science Advances Vol. 10 (2024) Nr. 48, eadp4670
  • Schrader, Thomas; Kubik, Stefan; Braun, Manfred.
    Günter Wulff (1935 –2023) : Father of Molecular Imprinting
    In: Angewandte Chemie International Edition Vol. 63 (2024) Nr. 12, e202402244
  • Schwarz, Tatjana; Ptok, Johannes; Damagnez, Maximilian; Menne, Christopher; Alizei, Elahe Salimi; Lang-Meli, Julia; Maas, Michelle; Habermann, Daniel; Hoffmann, Daniel; Schulze zur Wiesch, Julian; Lauer, Georg; Kefalakes, Helenie; Cornberg, Markus; Kraft, et al.
    HBV shows different levels of adaptation to HLA class I-associated selection pressure correlating with markers of replication
    In: Journal of Hepatology (2024) in press
  • Schmiedtchen, Marco; Maisuls, Iván; Siera, Hannah; Balszuweit, Jan; Wölper, Christoph; Giese, Michael R. A.; Haberhauer, Gebhard; Strassert, Cristian A.; Voskuhl, Jens.
    In situ Cyclization of Aromatic Thioethers in Emissive Materials to Generate Phosphorescent Dibenzothiophenes
    In: Angewandte Chemie International Edition (2024) in press
  • Gahlot, Pinki; Kravic, Bojana; Rota, Giulia; van den Boom, Johannes; Levantovsky, Sophie; Schulze, Nina; Maspero, Elena; Polo, Simona; Behrends, Christian; Meyer, Hemmo.
    Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH
    In: Molecular Cell (2024) pp. 1556 - 1569.e10
  • Pleuger, Richard; Cozma, Christian; Hohoff, Simone; Denkhaus, Christian; Dudziak, Alexander; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Vetter, Ingrid R.; Westermann, Stefan.
    Microtubule end-on attachment maturation regulates Mps1 association with its kinetochore receptor
    In: Current Biology Vol. 34 (2024) Nr. 11, pp. 2279 - 2293.e6
  • Schmidt, Mirko; Grethe, Christian; Recknagel, Sarah; Kipka, Gian-Marvin; Klink, Nikolas; Gersch, Malte.
    N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1
    In: Angewandte Chemie International Edition Vol. 63 (2024) Nr. 12, e202318849
  • Schuler, Martin; Cuppens, Kristof; Plönes, Till; Wiesweg, Marcel; Du Pont, Bert; Hegedus, Balazs; Köster, Johannes; Mairinger, Fabian; Darwiche, Kaid; Paschen, Annette; Maes, Brigitte; Vanbockrijck, Michel; Lähnemann, David; Zhao, Fang; Hautzel, Hubertus; et al.
    Neoadjuvant nivolumab with or without relatlimab in resectable non-small-cell lung cancer : A randomized phase 2 trial
    In: Nature Medicine Vol. 30 (2024) Nr. 6, pp. 1602 - 1611
  • Shelton, Spencer D.; House, Sara; Martins Nascentes Melo, Luiza; Ramesh, Vijayashree; Chen, Zhenkang; Wei, Tao; Wang, Xun; Llamas, Claire B.; Venigalla, Siva Sai Krishna; Menezes, Cameron J.; Allies, Gabriele; Krystkiewicz, Jonathan; Rösler, Jonas; Meckelm et al.
    Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis
    In: Science Advances Vol. 10 (2024) Nr. 44, eadk8801
  • Beaufort, Nathalie; Ingendahl, Linda; Merdanovic, Melisa; Schmidt, Andree; Podlesainski, David; Richter, Tim; Neumann, Thorben; Kuszner, Michael; Vetter, Ingrid R.; Stege, Patricia; Burston, Steven G.; Filipovic, Anto; Ruiz-Blanco, Yasser B.; Bravo Rodrigu et al.
    Rational correction of pathogenic conformational defects in HTRA1
    In: Nature Communications Vol. 15 (2024) Nr. 1, 5944
  • Lim, Wei Ming; Chew, Wei-Xiang; Esposito Verza, Arianna; Pesenti, Marion; Musacchio, Andrea; Surrey, Thomas.
    Regulation of minimal spindle midzone organization by mitotic kinases
    In: Nature Communications Vol. 15 (2024) Nr. 1, 9213
  • Phan, Julia; Chen, Brandon; Zhao, Zhiyu; Allies, Gabriele; Iannaccone, Antonella; Paul, Animesh; Cansiz, Feyza; Spina, Alberto; Leven, Anna-Sophia; Gellhaus, Alexandra; Schadendorf, Dirk; Kimmig, Rainer; Mettlen, Marcel; Tasdogan, Alpaslan; Morrison, Sean et al.
    Retrotransposons are co-opted to activate hematopoietic stem cells and erythropoiesis
    In: Science Vol. 386 (2024) Nr. 6722, pp. eado6836
  • Heinrich, Michael C.; Jones, Robin L.; George, Suzanne; Gelderblom, Hans; Schöffski, Patrick; von Mehren, Margaret; Zalcberg, John R.; Kang, Yoon-Koo; Razak, Albiruni Abdul; Trent, Jonathan; Attia, Steven; Le Cesne, Axel; Siontis, Brittany L.; Goldstein, D et al.
    Ripretinib versus sunitinib in gastrointestinal stromal tumor : ctDNA biomarker analysis of the phase 3 INTRIGUE trial
    In: Nature Medicine Vol. 30 (2024) Nr. 2, pp. 498 - 506
  • Conti, Duccio; Verza, Arianna Esposito; Pesenti, Marion E.; Cmentowski, Verena; Vetter, Ingrid R.; Pan, Dongqing; Musacchio, Andrea.
    Role of protein kinase PLK1 in the epigenetic maintenance of centromeres
    In: Science Vol. 385 (2024) Nr. 6713, pp. 1091 - 1097
  • Desch, Steffen; Zeymer, Uwe; Akin, Ibrahim; Behnes, Michael; Duerschmied, Daniel; Rassaf, Tienush; Mahabadi, Amir Abbas; Lehmann, Ralf; Eitel, Ingo; Graf, Tobias; Seidler, Tim; Schuster, Andreas; Thevathasan, Tharusan; Skurk, Carsten; Clemmensen, Peter; He et al.
    Routine extracorporeal life support in infarct-related cardiogenic shock : 1-year results of the ECLS-SHOCK trial
    In: European Heart Journal Vol. 45 (2024) Nr. 39, pp. 4200 - 4203
  • Imada, Shinya; Khawaled, Saleh; Shin, Heaji; Meckelmann, Sven W.; Whittaker, Charles A.; Corrêa, Renan Oliveira; Alquati, Chiara; Lu, Yixin; Tie, Guodong; Pradhan, Dikshant; Calibasi-Kocal, Gizem; Nascentes Melo, Luiza Martins; Allies, Gabriele; Rösler, Jo et al.
    Short-term post-fast refeeding enhances intestinal stemness via polyamines
    In: Nature (2024) in press
  • Polley, Soumitra; Raisch, Tobias; Ghetti, Sabrina; Körner, Marie; Terbeck, Melina; Gräter, Frauke; Raunser, Stefan; Aponte-Santamaría, Camilo; Vetter, Ingrid R.; Musacchio, Andrea.
    Structure of the human KMN complex and implications for regulation of its assembly
    In: Nature Structural & Molecular Biology Vol. 31 (2024) Nr. 6, pp. 861 - 873
  • Wever, Mark J A; Scommegna, Francesca R.; Egea-Rodriguez, Sara; Dehghani-Tafti, Saba; Brandao-Neto, Jose; Poisson, Jean-François; Helfrich, Iris; Antson, Alfred A.; Rodeschini, Vincent; Bax, Ben; Roche, Didier; Sanders, Cyril M.
    Structure-based discovery of first inhibitors targeting the helicase activity of human PIF1
    In: Nucleic Acids Research Vol. 52 (2024) Nr. 20, pp. 12616 - 12632
  • Buscaill, Pierre; Sanguankiattichai, Nattapong; Kaschani, Farnusch; Huang, Jie; Mooney, Brian C.; Li, Yuge; Lyu, Joy; Sueldo, Daniela; Kaiser, Markus; van der Hoorn, Renier A. L.
    Subtilase SBT5.2 inactivates flagellin immunogenicity in the plant apoplast
    In: Nature Communications Vol. 15 (2024) Nr. 1, 10431
  • Messmer, Julia M.; Thommek, Calvin; Piechutta, Manuel; Venkataramani, Varun; Wehner, Rebekka; Westphal, Dana; Schubert, Marc; Mayer, Chanté D.; Effern, Maike; Berghoff, Anna S.; Hinze, Daniel; Helfrich, Iris; Schadendorf, Dirk; Wick, Wolfgang; Hölzel, Mich et al.
    T lymphocyte recruitment to melanoma brain tumors depends on distinct venous vessels
    In: Immunity (2024) in press
  • Wirbel, Jakob; Bhatt, Ami S.; Probst, Alexander J.
    The journey to understand previously unknown microbial genes
    In: Nature Vol. 626 (2024) Nr. 7998, pp. 267 - 269
  • Musacchio, Andrea.
    Thirty years of structural changes
    In: Nature Structural & Molecular Biology Vol. 31 (2024) Nr. 1, pp. 4 - 5
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