ZMB Member Dirk Schadendorf

ZMB Member
Dirk Schadendorf

Next ZMB-Member
Dirk Schadendorf portrait
© UKE

Prof. Dr. Dirk Schadendorf

Director of:

Clinic for Dermatology

University Hospital Essen
Hufelandstraße 55
45147 Essen

Research Overview

  • Malignant melanoma
  • Merkel cell carcinoma
  • Squamous cell carcinoma
  • Basal cell carcinoma
  • Mycosis Fungoides/Sezary syndrome (T-Zell-Non-Hodgkin-Lymphoma)
  • Application observation

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Selected Publications

    Journal articles

  • Bührer, Emanuel; Kicinski, Michal; Mandala, Mario; Pe, Madeline; Long, Georgina V; Atkinson, Victoria; Blank, Christian U; Haydon, Andrew; Dalle, Stéphane; Khattak, Adnan; Carlino, Matteo S; Meshcheryakov, Andrey; Sandhu, Shahneen; Puig, Susana; Schadendorf, Dirk; Jamal, Rahima; Rutkowski, Piotr; van den Eertwegh, Alfonsus J M; Coens, Corneel; Grebennik, Dmitri; Krepler, Clemens; Robert, Caroline; Eggermont, Alexander M M
    Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054) : Long-term, health-related quality-of-life results from a double-blind, randomised, controlled, phase 3 trial
    In: The Lancet Oncology Vol. 25 (2024) Nr. 9, pp. 1202 - 1212
    Online Full Text: dx.doi.org/
  • Weischenfeldt, Joachim; Beroukhim, Rameen; Martincorena, Iñigo; Küppers, Ralf; Schadendorf, Dirk
    Analyses of non-coding somatic drivers in 2,658 cancer whole genomes
    In: Nature Vol. 578 (2023) Nr. 7793, pp. 102 - 111
    Online Full Text: dx.doi.org/
  • Calabrese, Claudia; Brazma, Alvis; Brooks, Angela N.; Rätsch, Gunnar; Küppers, Ralf; Schadendorf, Dirk
    Author Correction : Genomic basis for RNA alterations in cancer
    In: Nature Vol. 614 (2023) Nr. 7948, pp. E37
    Online Full Text: dx.doi.org/
  • Weischenfeldt, Joachim; Beroukhim, Rameen; Campbell, Peter J.; Küppers, Ralf; Schadendorf, Dirk
    Author Correction : Patterns of somatic structural variation in human cancer genomes
    In: Nature Vol. 614 (2023) Nr. 7948, pp. E38
    Online Full Text: dx.doi.org/ (Open Access)
  • Gerstung, Moritz; Jolly, Clemency; Leshchiner, Ignaty; Küppers, Ralf; Schadendorf, Dirk
    Author Correction : The evolutionary history of 2,658 cancers
    In: Nature Vol. 614 (2023) pp. E42
    Online Full Text: dx.doi.org/
  • Alexandrov, Ludmil B.; Kim, Jaegil; Haradhvala, Nicholas J.; Rozen, Steven G.; Stratton, Michael R.; Küppers, Ralf; Schadendorf, Dirk
    Author Correction: : The repertoire of mutational signatures in human cancer
    In: Nature Vol. 614 (2023) pp. E41
    Online Full Text: dx.doi.org/ (Open Access)
  • Cortés-Ciriano, Isidro; Küppers, Ralf; Schadendorf, Dirk; Park, Peter J.
    Author Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
    In: Nature Genetics Vol. 55 (2023) Nr. 6, 1076
    Online Full Text: dx.doi.org/ (Open Access)
  • Yuan, Yuan; Küppers, Ralf; Schadendorf, Dirk; Park, Keunchil; Campbell, Peter J.; Liang, Han
    Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers
    In: Nature Genetics Vol. 55 (2023) Nr. 6, pp. 1078
    Online Full Text: dx.doi.org/ (Open Access)
  • Akdemir, Kadir C.; Küppers, Ralf; Schadendorf, Dirk; Futreal, P. Andrew
    Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer
    In: Nature Genetics Vol. 55 (2023) Nr. 6, pp. 1079
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, et.al.
    Author Correction: Pan-cancer analysis of whole genomes
    In: Nature Vol. 614 (2023) Nr. 7948, pp. E39
    Online Full Text: dx.doi.org/ (Open Access)
  • Rodriguez-Martin, Bernardo; Schadendorf, Dirk; Küppers, Ralf; Campbell, Peter J.
    Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition
    In: Nature Genetics Vol. 55 (2023) Nr. 6, 1080
    Online Full Text: dx.doi.org/ (Open Access)
  • Zapatka, Marc; Schadendorf, Dirk; Lichter, Peter
    Author Correction: The landscape of viral associations in human cancers
    In: Nature Genetics Vol. 55 (2023) Nr. 6, pp. 1077
    Online Full Text: dx.doi.org/ (Open Access)
  • Cortés-Ciriano, Isidro; Küppers, Ralf; Schadendorf, Dirk; Park, Peter J.
    Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
    In: Nature Genetics Vol. 52 (2023) pp. 331 - 341
    Online Full Text: dx.doi.org/ (Open Access)
  • Yuan, Yuan; Küppers, Ralf; Schadendorf, Dirk; Park, Keunchil; Campbell, Peter J.; Liang, Han
    Comprehensive molecular characterization of mitochondrial genomes in human cancers
    In: Nature Genetics Vol. 52 (2023) pp. 342 - 352
    Online Full Text: dx.doi.org/ (Open Access)
  • Akdemir, Kadir C.; Küppers, Ralf; Schadendorf, Dirk; Futreal, P. Andrew
    Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer
    In: Nature Genetics Vol. 52 (2023) Nr. 3, pp. 294 - 305
    Online Full Text: dx.doi.org/ (Open Access)
  • Calabrese, Claudia; Brazma, Alvis; Brooks, Angela N.; Rätsch, Gunnar; Küppers, Ralf; Schadendorf, Dirk
    Genomic basis for RNA alterations in cancer
    In: Nature Vol. 578 (2023) Nr. 7793, pp. 129 - 136
    Online Full Text: dx.doi.org/
  • Gross, Neil D; Miller, David M; Khushalani, Nikhil I; Divi, Vasu; Ruiz, Emily S; Lipson, Evan J; Meier, Friedegund; Su, Yungpo Bernard; Swiecicki, Paul L; Atlas, Jennifer; Geiger, Jessica L; Hauschild, Axel; Choe, Jennifer H; Hughes, Brett G M; Schadendorf, Dirk; Patel, Vishal A; Homsi, Jade; Taube, Janis M; Lim, Annette M; Ferrarotto, Renata; Yoo, Suk-Young; Mathias, Melissa; Han, Hyunsil; Seebach, Frank; Lowy, Israel; Fury, Matthew G; Rischin, Danny
    Neoadjuvant cemiplimab and surgery for stage II–IV cutaneous squamous-cell carcinoma : follow-up and survival outcomes of a single-arm, multicentre, phase 2 study
    In: The Lancet Oncology Vol. 24 (2023) Nr. 11, pp. 1196 - 1205
    Online Full Text: dx.doi.org/
  • Garbe, Claus; Dummer, Reinhard; Amaral, Teresa; Amaria, Rodabe N.; Ascierto, Paolo A.; Burton, Elizabeth M.; Dreno, Brigitte; Eggermont, Alexander M. M.; Hauschild, Axel; Hoeller, Christoph; Kaufmann, Roland; Lebbe, Celeste; Mandala, Mario; Menzies, Alexander M.; Moreno, David; Michielin, Olivier; Nathan, Paul; Patel, Sapna P.; Robert, Caroline; Schadendorf, Dirk; Lorigan, Paul C.; Scolyer, Richard A.; Tawbi, Hussein A.; van de Wiel, Bart A.; Blank, Christian; Long, Georgina V.
    Neoadjuvant immunotherapy for melanoma is now ready for clinical practice
    In: Nature Medicine Vol. 29 (2023) Nr. 6, pp. 1310 - 1312
    Online Full Text: dx.doi.org/
  • Rodriguez-Martin, Bernardo; Schadendorf, Dirk; Küppers, Ralf; Campbell, Peter J.
    Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition
    In: Nature Genetics Vol. 52 (2023) Nr. 3, pp. 306 - 319
    Online Full Text: dx.doi.org/ (Open Access)
  • Weischenfeldt, Joachim; Beroukhim, Rameen; Campbell, Peter J.; Küppers, Ralf; Schadendorf, Dirk
    Patterns of somatic structural variation in human cancer genomes
    In: Nature Vol. 578 (2023) Nr. 7793, pp. 112 - 121
    Online Full Text: dx.doi.org/
  • Illert, A.L.; Stenzinger, A.; Bitzer, M.; Horak, P.; Gaidzik, V.I.; Möller, Y.; Beha, J.; Öner, Ö.; Schmitt, F.; Laßmann, S.; Ossowski, S.; Schaaf, C.P.; Hallek, M.; Brümmendorf, T.H.; Albers, P.; Fehm, T.; Brossart, P.; Glimm, H.; Schadendorf, Dirk; Bleckmann, A.; Brandts, C.H.; Esposito, I.; Mack, E.; Peters, C.; Bokemeyer, C.; Fröhling, S.; Kindler, T.; Algül, H.; Heinemann, V.; Döhner, H.; Bargou, R.; Ellenrieder, V.; Hillemanns, P.; Lordick, F.; Hochhaus, A.; Beckmann, M.W.; Pukrop, T.; Trepel, M.; Sundmacher, L.; Wesselmann, S.; Nettekoven, G.; Kohlhuber, F.; Heinze, O.; Budczies, J.; Werner, M.; Nikolaou, K.; Beer, A.J.; Tabatabai, G.; Weichert, W.; Keilholz, U.; Boerries, M.; Kohlbacher, O.; Duyster, J.; Thimme, R.; Seufferlein, T.; Schirmacher, P.; Malek, N.P.
    The German Network for Personalized Medicine to enhance patient care and translational research
    In: Nature Medicine Vol. 29 (2023) Nr. 6, pp. 1298 - 1301
    Online Full Text: dx.doi.org/
  • Zapatka, Marc; Küppers, Ralf; Schadendorf, Dirk; Lichter, Peter
    The landscape of viral associations in human cancers
    In: Nature Genetics (2023) Nr. 52, pp. 320 - 330
    Online Full Text: dx.doi.org/ (Open Access)
  • Alexandrov, Ludmil B.; Kim, Jaegil; Haradhvala, Nicholas J.; Rozen, Steven G.; Stratton, Michael R.; Küppers, Ralf; Schadendorf, Dirk
    The repertoire of mutational signatures in human cancer
    In: Nature Vol. 578 (2023) Nr. 7793, pp. 94 - 101
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Reimand, Jüri; PCAWG Consortium
    Author Correction : Pathway and network analysis of more than 2500 whole cancer genomes
    In: Nature Communications Vol. 13 (2022) 7566
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Feuerbach, Lars; PCAWG Consortium
    Author Correction : Genomic footprints of activated telomere maintenance mechanisms in cancer
    In: Nature Communications Vol. 13 (2022) 7574
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Shuai, Shimin; Stein, Lincoln D.; PCAWG Drivers and Functional Interpretation Working Group; PCAWG Consortium
    Author Correction : Combined burden and functional impact tests for cancer driver discovery using DriverPower
    In: Nature Communications Vol. 13 (2022) 7571
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Macintyre, Geoff; PCAWG Consortium
    Author Correction : Inferring structural variant cancer cell fraction
    In: Nature Communications Vol. 13 (2022) 7568
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Morris, Quaid D.; PCAWG Consortium
    Author Correction : Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig
    In: Nature Communications Vol. 13 (2022) 7567
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Stein, Lincoln D.; PCAWG Consortium
    Author Correction : A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns
    In: Nature Communications Vol. 13 (2022) 7573
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Reimand, Jüri; PCAWG Drivers and Functional Interpretation Working Group; PCAWG Consortium
    Author Correction : Integrative pathway enrichment analysis of multivariate omics data
    In: Nature Communications Vol. 13 (2022) 7570
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Bristow, Robert G.; Boutros, Paul C.; PCAWG Consortium
    Author Correction : Divergent mutational processes distinguish hypoxic and normoxic tumours
    In: Nature Communications Vol. 13 (2022) 7569
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Creighton, Chad J.; PCAWG Consortium
    Author Correction : High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations
    In: Nature Communications Vol. 13 (2022) 7572
    Online Full Text: dx.doi.org/ (Open Access)
  • Long, Georgina V; Luke, Jason J; Khattak, Muhammad A; de la Cruz Merino, Luis; Del Vecchio, Michele; Rutkowski, Piotr; Spagnolo, Francesco; Mackiewicz, Jacek; Chiarion-Sileni, Vanna; Kirkwood, John M; Robert, Caroline; Grob, Jean-Jacques; de Galitiis, Federica; Schadendorf, Dirk; Carlino, Matteo S; Mohr, Peter; Dummer, Reinhard; Gershenwald, Jeffrey E; Yoon, Charles H; Wu, Xi Lawrence; Fukunaga-Kalabis, Mizuho; Krepler, Clemens; Eggermont, Alexander M M; Ascierto, Paolo A
    Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma (KEYNOTE-716) : distant metastasis-free survival results of a multicentre, double-blind, randomised, phase 3 trial
    In: The Lancet Oncology Vol. 23 (2022) Nr. 11, pp. 1378 - 1388
    Online Full Text: dx.doi.org/
  • Chauvistré, Heike; Shannan, Batool; Daignault-Mill, Sheena M.; Ju, Robert J.; Picard, Daniel; Egetemaier, Stefanie; Váraljai, Renáta; Gibhardt, Christine S.; Sechi, Antonio; Kaschani, Farnusch; Keminer, Oliver; Stehbens, Samantha J.; Liu, Qin; Yin, Xiangfan; Jeyakumar, Kirujan; Vogel, Felix C. E.; Krepler, Clemens; Rebecca, Vito W.; Kubat, Linda; Lueong, Smiths S.; Forster, Jan; Horn, Susanne; Remke, Marc; Ehrmann, Michael; Paschen, Annette; Becker, Jürgen; Helfrich, Iris; Rauh, Daniel; Kaiser, Markus; Gul, Sheraz; Herlyn, Meenhard; Bogeski, Ivan; Rodríguez-López, José Neptuno; Haass, Nikolas K.; Schadendorf, Dirk; Rösch, Alexander
    Persister state-directed transitioning and vulnerability in melanoma
    In: Nature Communications Vol. 13 (2022) Nr. 1, 3055
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Bottomley, Andrew; Coens, Corneel; Mierzynska, Justyna; Blank, Christian U; Mandalà, Mario; Long, Georgina V; Atkinson, Victoria G; Dalle, Stéphane; Haydon, Andrew M; Meshcheryakov, Andrey; Khattak, Adnan; Carlino, Matteo S; Sandhu, Shahneen; Puig, Susana; Ascierto, Paolo A; Larkin, James; Lorigan, Paul C; Rutkowski, Piotr; Schadendorf, Dirk; Koornstra, Rutger; Hernandez-Aya, Leonel; Di Giacomo, Anna Maria; van den Eertwegh, Alfonsus J M; Grob, Jean-Jacques; Gutzmer, Ralf; Jamal, Rahima; van Akkooi, Alexander C J; Krepler, Clemens; Ibrahim, Nageatte; Marreaud, Sandrine; Kicinski, Michal; Suciu, Stefan; Robert, Caroline; Eggermont, Alexander M M; Lesimple, Thierry; Maio, Michele; Linette, Gerald; Mortier, Laurent; Svane, Inge Marie; Schachter, Jacob; Brown, Michael; Hersey, Peter; Barrow, Catherine; Kudchadkar, Ragini; Dutriaux, Caroline; Song, Xinni; Quaglino, Pietro; Queirolo, Paola; Meier, Friedegund; Stroyakovskiy, Daniil; Guillot, Bernard; Romero, Pablo Luis Ortiz; Bastholt, Lars; Garbe, Claus; Grange, Florent; Mohr, Peter; Algazi, Alain; Bechter, Oliver; Hernberg, Micaela; Loquai, Carmen; Meiss, Frank; Chiarion Sileni, Vanna; Bar-Sela, Gil; Fitzharris, Bernard; Saiag, Philippe; Arnault, Jean-Philippe; Simon, Jan-Christoph; Stephens, Rosalie; Baurain, Jean-Francois; Lebbe, Célèste; Combemale, Patrick; Dummer, Reinhard; Hauschild, Axel; Parente, Phillip; Yamazaki, Naoya; Milhem, Mohammed; Leccia, Marie-Thérèse; Geoffrois, Lionel; Kretschmer, Lutz; Dunwoodie, Elaine; Walker, John; Lotem, Michal; Hendler, Daniel; Mackiewicz, Andrzej; Sekulovic, Lidija; Dzienis, Marcin; Hospers, Geke A.P.; Siano, Marco; Hassel, Jessica; Corrie, Philippa; Passos, Maria-Jose; Levin, Max; Hoeller, Christoph; Machet, Laurent; Hallmeyer, Sigrun; Waterston, Ashita; Descamps, Vincent; Kiecker, Felix; Aarts, Maureen; Schmidt, Henrik; Raimundo, Ana; Nyakas, Marta; Lacour, Jean-Philippe; Berking, Carola; Ferrucci, Pier Francesco; Jameson, Michael; Kim, Kevin; Yokota, Kenji; Kerger, Joseph; Aubin, François; Groenewegen, Gerard; Kapiteijn, Helena; Boehncke, Wolf-Henning; Utikal, Jochen; Casasola, Richard; Marshall, Ernest; Ferraresi, Virginia; Richtig, Erika; Matkovic, Suzana; Inozume, Takashi; Crook, Timothy; McNeil, Catriona; Kiyohara, Yoshio; Avril, Marie-Francoise; Hein, Rüdiger; Terheyden, Patrick; Nathan, Paul; Aoi, Jun; Skytta, Tanja; Jouary, Thomas; Takenouchi, Tatsuya; Straume, Oddbjorn; Martins, César; Mukhametshina, Guzel
    Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054) : health-related quality-of-life results from a double-blind, randomised, controlled, phase 3 trial
    In: The Lancet Oncology Vol. 22 (2021) Nr. 5, pp. 655 - 664
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Eggermont, Alexander M M; Blank, Christian U; Mandalà, Mario; Long, Georgina V; Atkinson, Victoria G; Dalle, Stéphane; Haydon, Andrew M; Meshcheryakov, Andrey; Khattak, Adnan; Carlino, Matteo S; Sandhu, Shahneen; Larkin, James; Puig, Susana; Ascierto, Paolo A; Rutkowski, Piotr; Schadendorf, Dirk; Koornstra, Rutger; Hernandez-Aya, Leonel; Di Giacomo, Anna Maria; van den Eertwegh, Alfonsus J M; Grob, Jean-Jacques; Gutzmer, Ralf; Jamal, Rahima; Lorigan, Paul C; van Akkooi, Alexander C J; Krepler, Clemens; Ibrahim, Nageatte; Marreaud, Sandrine; Kicinski, Michal; Suciu, Stefan; Robert, Caroline; Menzies, Alex; Lesimple, Thierry; Maio, Michele; Linette, Gerald; Brown, Michael; Hersey, Peter; Svane, Inge Marie; Mortier, Laurent; Schachter, Jacob; Barrow, Catherine; Kudchadkar, Ragini; Song, Xinni; Dutriaux, Caroline; Quaglino, Pietro; Meier, Friedegund; Queirolo, Paola; Stroyakovskiy, Daniil; Bastholt, Lars; Guillot, Bernard; Garbe, Claus; Ortiz Romero, Pablo Luis; Grange, Florent; Mohr, Peter; Algazi, Alain; Bechter, Oliver; Hernberg, Micaela; Arnault, Jean-Philippe; Saiag, Philippe; Loquai, Carmen; Meiss, Frank; Simon, Jan-Christoph; Bar-Sela, Gil; Chiarion Sileni, Vanna; Fitzharris, Bernard; McCrystal, Mike; Parente, Phillip; Baurain, Jean-Francois; Combemale, Patrick; Lebbe, Célèste; Hauschild, Axel; Yamazaki, Naoya; Dummer, Reinhard; Milhem, Mohammed; Dzienis, Marcin; Walker, John; Geoffrois, Lionel; Leccia, Marie-Thérèse; Kretschmer, Lutz; Hendler, Daniel; Lotem, Michal; Mackiewicz, Andrzej; Sekulovic, Lidija; Dunwoodie, Elaine; Hoeller, Christoph; Machet, Laurent; Hassel, Jessica; Hospers, Geke A.P.; Passos, Maria-Jose; Levin, Max; Fehr, Martin; Corrie, Philippa; Waterston, Ashita; Hallmeyer, Sigrun; Schmidt, Henrik; Descamps, Vincent; Lacour, Jean-Philippe; Berking, Carola; Kiecker, Felix; Ferrucci, Pier Francesco; Yokota, Kenji; Aarts, Maureen; Jameson, Michael; Winge-Main, Anna Katharina; Ferreira, Paula; Kim, Kevin; McNeil, Catriona; Hofmann-Wellenhof, Reiner; Kerger, Joseph; Aubin, François; Utikal, Jochen; Ferraresi, Virginia; Inozume, Takashi; Kiyohara, Yoshio; Groenewegen, Gerard; Kapiteijn, Helena; Matkovic, Suzana; Boehncke, Wolf-Henning; Casasola, Richard; Crook, Timothy; Marshall, Ernest; Skytta, Tanja; Avril, Marie-Francoise; Jouary, Thomas; Hein, Rüdiger; Terheyden, Patrick; Aoi, Jun; Takenouchi, Tatsuya; Straume, Oddbjorn; Martins, César; Mukhametshina, Guzel; Nathan, Paul
    Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054) : distant metastasis-free survival results from a double-blind, randomised, controlled, phase 3 trial
    In: The Lancet Oncology Vol. 22 (2021) Nr. 5, pp. 643 - 654
    Online Full Text: dx.doi.org/
  • Syeda, Mahrukh M.; Wiggins, Jennifer M.; Corless, Broderick C; Long, Georgina V.; Flaherty, Keith T.; Schadendorf, Dirk; Nathan, Paul D.; Robert, Caroline; Ribas, Antoni; Davies, Michael A.; Grob, Jean Jacques; Gasal, Eduard; Squires, Matthew; Marker, Mahtab; Garrett, James; Brase, Jan C.; Polsky, David
    Circulating tumour DNA in patients with advanced melanoma treated with dabrafenib or dabrafenib plus trametinib : A clinical validation study
    In: The Lancet Oncology Vol. 22 (2021) Nr. 3, pp. 370 - 380
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Le Rhun, E.; Guckenberger, M.; Smits, M.; Dummer, R.; Bachelot, T.; Sahm, F.; Galldiks, N.; de Azambuja, E.; Berghoff, A.S.; Metellus, P.; Peters, S.; Hong, Y.-K.; Winkler, F.; Schadendorf, Dirk; van den Bent, M.; Seoane, J.; Stahel, R.; Minniti, G.; Wesseling, P.; Weller, M.; Preusser, M.
    EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumours
    In: Annals of Oncology Vol. 32 (2021) Nr. 11, pp. 1332 - 1347
    Online Full Text: dx.doi.org/ (Open Access)
  • Frangieh, Chris J.; Melms, Johannes C.; Thakore, Pratiksha I.; Geiger-Schuller, Kathryn R.; Ho, Patricia; Luoma, Adrienne M.; Cleary, Brian; Jerby-Arnon, Livnat; Malu, Shruti; Cuoco, Michael S.; Zhao, Maryann; Ager, Casey R.; Rogava, Meri; Hovey, Lila; Rotem, Asaf; Bernatchez, Chantale; Wucherpfennig, Kai W.; Johnson, Bruce E.; Rozenblatt-Rosen, Orit; Schadendorf, Dirk; Regev, Aviv; Izar, Benjamin
    Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion
    In: Nature Genetics Vol. 53 (2021) Nr. 3, pp. 332 - 341
    Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Stein, Lincoln D.; PCAWG Consortium
    A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns
    In: Nature Communications Vol. 11 (2020) 728
    Online Full Text: dx.doi.org/ (Open Access)
  • Dummer, Reinhard; Brase, Jan C.; Garrett, James; Campbell, Catarina D.; Gasal, Eduard; Squires, Matthew; Gusenleitner, Daniel; Santinami, Mario; Atkinson, Victoria; Mandalà, Mario; Chiarion-Sileni, Vanna; Flaherty, Keith; Larkin, James; Robert, Caroline; Kefford, Richard; Kirkwood, John M.; Hauschild, Axel; Schadendorf, Dirk; Long, Georgina V.
    Adjuvant dabrafenib plus trametinib versus placebo in patients with resected, BRAFV⁶⁰⁰-mutant, stage III melanoma (COMBI-AD) : Exploratory biomarker analyses from a randomised, phase 3 trial
    In: The Lancet Oncology Vol. 21 (2020) Nr. 3, pp. 358 - 372
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Eggermont, Alexander M. M.; Kicinski, Michal; Blank, Christian U.; Mandala, Mario; Long, Georgina V.; Atkinson, Victoria; Dalle, Stéphane; Haydon, Andrew; Khattak, Adnan; Carlino, Matteo S.; Sandhu, Shahneen; Larkin, James; Puig, Susana; Ascierto, Paolo A.; Rutkowski, Piotr; Schadendorf, Dirk; Koornstra, Rutger; Hernandez-Aya, Leonel; Di Giacomo, Anna Maria; Van Den Eertwegh, Alfonsus J. M.; Grob, Jean-Jacques; Gutzmer, Ralf; Jamal, Rahima; Lorigan, Paul C.; Krepler, Clemens; Ibrahim, Nageatte; Marreaud, Sandrine; Van Akkooi, Alexander; Robert, Caroline; Suciu, Stefan
    Association between Immune-Related Adverse Events and Recurrence-Free Survival among Patients with Stage III Melanoma Randomized to Receive Pembrolizumab or Placebo : A Secondary Analysis of a Randomized Clinical Trial
    In: JAMA Oncology Vol. 6 (2020) Nr. 4, pp. 519 - 527
    Online Full Text: dx.doi.org/ (Open Access)
  • Puzanov, Igor; Ribas, Antoni; Robert, Caroline; Schachter, Jacob; Nyakas, Marta; Daud, Adil; Arance, Ana; Carlino, Matteo S.; O'Day, Steven J.; Long, Georgina V.; Margolin, Kim A.; Dummer, Reinhard; Schadendorf, Dirk; Lutzky, Jose; Ascierto, Paolo A.; Tarhini, Ahmad; Lin, Jianxin; Mogg, Robin; Homet Moreno, Blanca; Ibrahim, Nageatte; Hamid, Omid
    Association of BRAF V600E/K Mutation Status and Prior BRAF/MEK Inhibition with Pembrolizumab Outcomes in Advanced Melanoma : Pooled Analysis of 3 Clinical Trials
    In: JAMA Oncology Vol. 6 (2020) Nr. 8, pp. 1256 - 1264
    Online Full Text: dx.doi.org/ (Open Access)
  • Liu, David; Schilling, Bastian; Liu, Derek; Sucker, Antje; Livingstone, Elisabeth; Jerby-Arnon, Livnat; Zimmer, Lisa; Gutzmer, Ralf; Satzger, Imke; Loquai, Carmen; Grabbe, Stephan; Vokes, Natalie; Margolis, Claire A.; Conway, Jake; He, Meng Xiao; Elmarakeby, Haitham; Dietlein, Felix; Miao, Diana; Tracy, Adam; Gogas, Helen; Goldinger, Simone M.; Utikal, Jochen; Blank, Christian U.; Rauschenberg, Ricarda; von Bubnoff, Dagmar; Krackhardt, Angela; Weide, Benjamin; Haferkamp, Sebastian; Kiecker, Felix; Izar, Ben; Garraway, Levi; Regev, Aviv; Flaherty, Keith; Paschen, Annette; Van Allen, Eliezer M.; Schadendorf, Dirk
    Author Correction: Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma
    In: Nature Medicine Vol. 26 (2020) Nr. 7, pp. 1147
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk
    Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
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    Author Correction: Tertiary lymphoid structures improve immunotherapy and survival in melanoma
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    Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours
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    Cemiplimab in locally advanced cutaneous squamous cell carcinoma : results from an open-label, phase 2, single-arm trial
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    Combined PD-1, BRAF and MEK inhibition in advanced BRAF-mutant melanoma : safety run-in and biomarker cohorts of COMBI-i
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    Combined burden and functional impact tests for cancer driver discovery using DriverPower
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    Divergent mutational processes distinguish hypoxic and normoxic tumours
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    Elevated baseline serum PD-1 or PD-L1 predicts poor outcome of PD-1 inhibition therapy in metastatic melanoma
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    Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility
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    Genomic footprints of activated telomere maintenance mechanisms in cancer
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    High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations
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    Inferring structural variant cancer cell fraction
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    Integrative pathway enrichment analysis of multivariate omics data
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    Rationale for Immune Checkpoint Inhibitors plus Targeted Therapy in Metastatic Melanoma : A Review
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    Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig
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    Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
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    Paclitaxel with or without trametinib or pazopanib in advanced wild-type BRAF melanoma (PACMEL) : a multicentre, open-label, randomised, controlled phase II trial
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    Survival Outcomes in Patients with Previously Untreated BRAF Wild-Type Advanced Melanoma Treated with Nivolumab Therapy : Three-Year Follow-up of a Randomized Phase 3 Trial
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    Treatment in metastatic melanoma : Time to re-think
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    Adjuvant melanoma therapy with new drugs : Should physicians continue to focus on metastatic disease or use it earlier in primary melanoma?
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    Adverse events (AEs) over time in patients (pts) treated with adjuvant dabrafenib plus trametinib (D + T) or placebo (Pbo) in the COMBI-AD trial
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    Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy : a retrospective, multicohort analysis
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    Encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF-mutant melanoma (COLUMBUS) : a multicentre, open-label, randomised phase 3 trial
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