ZMB Site - Medical Faculty / University Hospital Essen

ZMB Research
Sites

Medical Faculty / University Hospital Essen

Selected Publications

Prof. Dr.Sebastian Bauer

Group: Translational Sarcoma Research

ZMB Research Program: Oncology

Prof. Dr. Dr.Jürgen Becker

Group: Translational Skin Cancer Research

ZMB Research Program: Oncology

Prof. Dr.Ivo Bendix

Group: Experimental Perinatal Neuroscience

Prof. Dr. Dr.Sven Brandau

Group:Otorhinolaryngology

ZMB Research Program: Oncology

Prof. Dr.Jan Buer

Director of: Institute of Medical Microbiology

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Elke Cario

Group: Experimental Gastroenterology

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Ulf Dittmer

Director of: Institute of Virology

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Nicole Dünker

Group: Neuroanatomy

ZMB Research Program: Molecular and Chemical Cell Biology

Prof. Dr.Joachim Fandrey

Director of: Institute of Physiology

ZMB Research Program: Molecular and Chemical Cell Biology

Jun.-Prof. Dr.Katja Ferenz

Group: Institute of Physiology

ZMB Research Program: Molecular and Chemical Cell Biology

Prof. Dr.Katharina Fleischhauer

Director of: Institute for Experimental Cellular Therapy

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Stefanie Flohé

Group: Immunology Sepsis/Trauma

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Dagmar Führer-Sakel

Director of: Clinic for Endocrinology, Diabetology and Metabolism

ZMB Research Program: Oncology

Prof. Dr.Bernd Giebel

Group: Giebel Lab

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Barbara M. Grüner

Group: Molecular Tumorpathology

ZMB Research Program: Oncology

Prof. Dr.Barbara Grünwald

Group: Tumor Heterogeneity and Translational Systems Biology

ZMB Research Program: Oncology

Prof. Dr.Erich Gulbins

Director of: Department of Molecular Biology

ZMB Research Program: Oncology

Prof. Dr.Matthias Gunzer

Director of: Institute of Experimental Immunology & Imaging

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Wiebke Hansen

Group: Molecular Infection Immunology

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Ulrike Hendgen-Cotta

Manager of: Cardio Science Labs

ZMB Research Program: Molecular and Chemical Cell Biology

Prof. Dr.Dirk M. Hermann

Group: Vascular Neurology, Dementia and Age Research

ZMB Research Program: Molecular and Chemical Cell Biology

Prof. Dr.Ken Herrmann

Group: Clinic for Nuclear Medicine

ZMB Research Program: Oncology

Prof. Dr.Heike Heuer

Group: Molecular Thyroidology

ZMB Research Program: Molecular and Chemical Cell Biology

PD Dr.Josephine Herz

Group: Experimental Perinatal Neuroscience

ZMB Research Program: Molecular and Chemical Cell Biology

Prof. Dr.Anke Hinney

Group: LVR Clinic for Psychiatry Essen

ZMB Research Program: Molecular and Chemical Cell Biology

Prof. Dr.Peter Horn

Director of: Institute for Transfusion Medicine

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.George Iliakis

Group: Radiation Biology

ZMB Research Program: Oncology

Prof. Dr.Jadwiga Jablonska-Koch

Group:Otorhinolaryngology (ENT)

ZMB Research Program: Oncology

Prof. Dr.Verena Jendrossek

Group: Molecular Cell Biology

ZMB Research Program: Oncology

Prof. Dr.Carsten Kirschning

Group: Regulation of Pathogen-specific Immunity

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Diana Klein

Group: Vascular Remodeling & Normal Tissue Protection

ZMB Research Program: Oncology

Prof. Dr.Christoph Kleinschnitz

Director of: Clinic for Neurology

ZMB Research Program: Molecular and Chemical Cell Biology

PD Dr.Adalbert Krawczyk

Group: Clinic for Infectious Diseases

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Ralf Küppers

Director of: Institute of Cell Biology (Tumor Research)

ZMB Research Program: Oncology

Prof. Dr.Karl Sebastian Lang

Director of: Institute of Immunology

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Jun.-Prof. Dr.Elisabeth Littwitz-Salomon

Group: Immune Metabolism in Infection and Cancer

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Dietmar Lohmann

Group: Ophthalmic Oncology and Genetics

ZMB Research Program: Molecular and Chemical Cell Biology

Prof. Dr.Katharina Lückerath

Group: Preclinical Theranostics in Nuclear Medicine

ZMB Research Program: Oncology

PD Dr.Johann Matschke

Group: Metabolism and Radiation Response

ZMB Research Program: Oncology

Prof. Dr.Annette Paschen

Group: Molecular Tumor Immunology

ZMB Research Program: Oncology

Dr.Samuel Peña-Llopis

Junior Group: Translational Genomics in Solid Tumors

ZMB Research Program: Oncology

Prof. Dr.Tienush Rassaf

Director of: Clinic for Cardiology and Vascular Medicine

ZMB Research Program: Oncology

Prof. Dr.Christian Reinhardt

Director of: Clinic for Hematology and Stem Cell Transplantation

ZMB Research Program: Oncology

Prof. Dr.Alexander Roesch

Group: Tumor Heterogeneity & Plasticity

ZMB Research Program: Oncology

Prof. Dr.Dirk Schadendorf

Director of: Clinic for Dermatology

ZMB Research Program: Oncology

Prof. Dr.Björn Scheffler

Group: Translational Neurooncology

ZMB Research Program: Oncology

Prof. Dr.Alexander Schramm

Group: Molecular Oncology

ZMB Research Program: Oncology

Prof. Dr.Martin Schuler

Director of: Department of Medical Oncology

ZMB Research Program: Oncology

Prof. Dr.Winfried Siffert

Director of: Institute of Pharmacogenetics

ZMB Research Program: Molecular and Chemical Cell Biology

Prof. Dr. Dr.Jens Siveke

Group: Bridge Institute for Experimental Tumor Therapy

ZMB Research Program: Oncology

PD Dr.Kathrin Sutter

TRR60 Junior Research Group: Interferone-alpha Subtypes

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr. Dr.Alpaslan Tasdogan

Group: Tumor Metabolism

ZMB Research Program: Oncology

PD Dr.Basant Kumar Thakur

Group: Cancer Exosome Research Lab

ZMB Research Program: Oncology

Prof. Dr.Kathrin Thedieck

Group: Metabolism, Senescence and Autophagy

ZMB Research Program: Molecular and Chemical Cell Biology

Dr.Silvia Vega-Rubín-de-Celis

Junior Research Group: Autophagy in Cancer

ZMB Research Program: Oncology

Prof. Dr.Gunther Wennemuth

Director of: Institute of Anatomy

ZMB Research Program: Molecular and Chemical Cell Biology

Prof. Dr.Astrid Westendorf

Group: Infection Immunology

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

2024

Heinrich, Michael C.; Zhang, Xinhua; Jones, Robin L.; George, Suzanne; Serrano, César; Deng, Yanhong; Bauer, Sebastian; Cai, Shirong; Wu, Xin; Zhou, Yongjian; Tao, Kaixiong; Zheng, Zhichao; Zhang, Jun; Cui, Yuehong; Cao, Hui; Wang, Meining; Hu, Jin; Yang, Jason; Li, Jian; Shen, Lin

Clinical Benefit of Avapritinib in KIT-Mutant Gastrointestinal Stromal Tumors : A Post Hoc Analysis of the Phase I NAVIGATOR and Phase I/II CS3007-001 Studies

In: Clinical Cancer Research Vol. 30 (2024) Nr. 4, pp. 719 - 728

Online Full Text: dx.doi.org/
Arrieta-Bolaños, Esteban; van der Burg, Lars L. J.; Gedde-Dahl, Tobias; Robin, Marie; Salmenniemi, Urpu; Kröger, Nicolaus; Yakoub-Agha, Ibrahim; Huynh, Anne; Crawley, Charles; Deconinck, Eric; Bulabois, Claude Eric; Forcade, Edouard; Tholouli, Eleni; van der Hem, Joost G. K.; van Balen, Peter; Hoogenboom, Jorinde D.; de Wreede, Liesbeth C.; Malard, Florent; Ruggeri, Annalisa; Fleischhauer, Katharina

Directionality of HLA-DP permissive mismatches improves risk prediction in HCT for acute leukemia and MDS

In: Blood Vol. 144 (2024) Nr. 16, pp. 1747 - 1751

Online Full Text: dx.doi.org/
Dobersalske, Celia; Rauschenbach, Laurèl; Hua, Yichao; Berliner, Christoph; Steinbach, Anita; Grüneboom, Anika; Kokkaliaris, Konstantinos D.; Heiland, Dieter H.; Berger, Pia; Langer, Sarah; Tan, Chin L.; Stenzel, Martin; Landolsi, Somaya; Weber, Flora; Darkwah Oppong, Marvin; Werner, Rudolf A.; Gull, Hanah; Schröder, Thomas; Linsenmann, Thomas; Buck, Andreas K.; Gunzer, Matthias; Stuschke, Martin; Keyvani, Kathy; Forsting, Michael; Glas, Martin; Kipnis, Jonathan; Steindler, Dennis A.; Reinhardt, Hans Christian; Green, Edward W.; Platten, Michael; Tasdogan, Alpaslan; Herrmann, Ken; Rambow, Florian; Cima, Igor; Sure, Ulrich; Scheffler, Björn

Cranioencephalic functional lymphoid units in glioblastoma

In: Nature Medicine (2024) in press

Online Full Text: dx.doi.org/ (Open Access)
Käver, Larissa; Hinney, Anke; Rajcsanyi, Luisa Sophie; Maier, Hannah Benedictine; Frieling, Helge; Steiger, Howard; Voelz, Clara; Beyer, Cordian; Trinh, Stefanie; Seitz, Jochen

Epigenetic alterations in patients with anorexia nervosa : A systematic review

In: Molecular Psychiatry (2024) in press

Online Full Text: dx.doi.org/ (Open Access)
Pozniak, Joanna; Pedri, Dennis; Landeloos, Ewout; Van Herck, Yannick; Antoranz, Asier; Vanwynsberghe, Lukas; Nowosad, Ada; Roda, Niccolò; Makhzami, Samira; Bervoets, Greet; Maciel, Lucas Ferreira; Pulido-Vicuña, Carlos Ariel; Pollaris, Lotte; Seurinck, Ruth; Zhao, Fang; Flem-Karlsen, Karine; Damsky, William; Chen, Limin; Karagianni, Despoina; Cinque, Sonia; Kint, Sam; Vandereyken, Katy; Rombaut, Benjamin; Voet, Thierry; Vernaillen, Frank; Annaert, Wim; Lambrechts, Diether; Boecxstaens, Veerle; Saeys, Yvan; van den Oord, Joost; Bosisio, Francesca; Karras, Panagiotis; Shain, A. Hunter; Bosenberg, Marcus; Leucci, Eleonora; Paschen, Annette; Rambow, Florian; Bechter, Oliver; Marine, Jean-Christophe

A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma

In: Cell Vol. 187 (2024) Nr. 1, pp. 166 - 183.e25

Online Full Text: dx.doi.org/ (Open Access)
Long, Georgina V.; Hauschild, Axel; Santinami, Mario; Kirkwood, John M.; Atkinson, Victoria; Mandala, Mario; Merelli, Barbara; Sileni, Vanna Chiarion; Nyakas, Marta; Haydon, Andrew; Dutriaux, Caroline; Robert, Caroline; Mortier, Laurent; Schachter, Jacob; Schadendorf, Dirk; Lesimple, Thierry; Plummer, Ruth; Larkin, James; Tan, Monique; Adnaik, Sachin Bajirao; Burgess, Paul; Jandoo, Tarveen; Dummer, Reinhard

Final Results for Adjuvant Dabrafenib plus Trametinib in Stage III Melanoma

In: The New England Journal of Medicine (2024) in press

Online Full Text: dx.doi.org/
Roos, Andreas; Schmitt, Linda-Isabell; Hansmann, Christina; Hezel, Stefanie; Salmanian, Schahin; Hentschel, Andreas; Meyer, Nancy; Marina, Adela Della; Kölbel, Heike; Kleinschnitz, Christoph; Schara-Schmidt, Ulrike; Leo, Markus; Hagenacker, Tim

Alteration of LARGE1 abundance in patients and a mouse model of 5q-associated spinal muscular atrophy

In: Acta Neuropathologica Vol. 147 (2024) Nr. 1, 53

Online Full Text: dx.doi.org/ (Open Access)
Teuber, A.; Schulz, T.; Fletcher, B.S.; Gontla, R.; Mühlenberg, Thomas; Zischinsky, M.-L.; Niggenaber, J.; Weisner, J.; Kleinbölting, S.B.; Lategahn, J.; Sievers, S.; Müller, M.P.; Bauer, Sebastian; Rauh, D.

Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA

In: Nature Communications Vol. 15 (2024) Nr. 1, 63

Online Full Text: dx.doi.org/ (Open Access)
Lu, I-Na; Cheung, Phyllis Fung-Yi; Heming, Michael; Thomas, Christian; Giglio, Giovanni; Leo, Markus; Erdemir, Merve; Wirth, Timo; König, Simone; Dambietz, Christine A.; Schroeter, Christina B.; Nelke, Christopher; Siveke, Jens; Ruck, Tobias; Klotz, Luisa; Haider, Carmen; Höftberger, Romana; Kleinschnitz, Christoph; Wiendl, Heinz; Hagenacker, Tim; Meyer zu Horste, Gerd

Cell-mediated cytotoxicity within CSF and brain parenchyma in spinal muscular atrophy unaltered by nusinersen treatment

In: Nature Communications Vol. 15 (2024) Nr. 1, 4120

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Heger, Jan-Michel; Mattlener, Julia; Schneider, Jessica; Gödel, Philipp; Sieg, Noëlle; Ullrich, Fabian; Lewis, Richard; Bucaciuc-Mracica, Teodora; Schwarz, Roland F.; Rueß, Daniel; Ruge, Maximilian I.; Montesinos-Rongen, Manuel; Deckert, Martina; Blau, Tobias; Kutsch, Nadine; Balke-Want, Hyatt; Weiss, Jonathan; Becker, Kerstin; Reinhardt, H. Christian; Hallek, Michael; Borchmann, Peter; von Tresckow, Bastian; Borchmann, Sven

Entirely noninvasive outcome prediction in central nervous system lymphomas using circulating tumor DNA

In: Blood Vol. 143 (2024) Nr. 6, pp. 522 - 534

Online Full Text: dx.doi.org/
Phan, Julia; Chen, Brandon; Zhao, Zhiyu; Allies, Gabriele; Iannaccone, Antonella; Paul, Animesh; Cansiz, Feyza; Spina, Alberto; Leven, Anna-Sophia; Gellhaus, Alexandra; Schadendorf, Dirk; Kimmig, Rainer; Mettlen, Marcel; Tasdogan, Alpaslan; Morrison, Sean J.

Retrotransposons are co-opted to activate hematopoietic stem cells and erythropoiesis

In: Science Vol. 386 (2024) Nr. 6722, pp. eado6836

Online Full Text: dx.doi.org/
Wever, Mark J A; Scommegna, Francesca R.; Egea-Rodriguez, Sara; Dehghani-Tafti, Saba; Brandao-Neto, Jose; Poisson, Jean-François; Helfrich, Iris; Antson, Alfred A.; Rodeschini, Vincent; Bax, Ben; Roche, Didier; Sanders, Cyril M.

Structure-based discovery of first inhibitors targeting the helicase activity of human PIF1

In: Nucleic Acids Research Vol. 52 (2024) Nr. 20, pp. 12616 - 12632

Online Full Text: dx.doi.org/ (Open Access)
Schwarz, Tatjana; Ptok, Johannes; Damagnez, Maximilian; Menne, Christopher; Alizei, Elahe Salimi; Lang-Meli, Julia; Maas, Michelle; Habermann, Daniel; Hoffmann, Daniel; Schulze zur Wiesch, Julian; Lauer, Georg; Kefalakes, Helenie; Cornberg, Markus; Kraft, Anke RM.; Gliga, Smaranda; Bock, Hans H.; Horn, Peter A.; Maini, Mala K.; Thimme, Robert; Wedemeyer, Heiner; Nattermann, Jacob; Heinemann, Falko M.; Luedde, Tom; Neumann-Haefelin, Christoph; Walker, Andreas; Timm, Jörg

HBV shows different levels of adaptation to HLA class I-associated selection pressure correlating with markers of replication

In: Journal of Hepatology (2024) in press

Online Full Text: dx.doi.org/ (Open Access)
Shelton, Spencer D.; House, Sara; Martins Nascentes Melo, Luiza; Ramesh, Vijayashree; Chen, Zhenkang; Wei, Tao; Wang, Xun; Llamas, Claire B.; Venigalla, Siva Sai Krishna; Menezes, Cameron J.; Allies, Gabriele; Krystkiewicz, Jonathan; Rösler, Jonas; Meckelmann, Sven W.; Zhao, Peihua; Rambow, Florian; Schadendorf, Dirk; Zhao, Zhiyu; Gill, Jennifer G.; DeBerardinis, Ralph J.; Morrison, Sean J.; Tasdogan, Alpaslan; Mishra, Prashant

Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis

In: Science Advances Vol. 10 (2024) Nr. 44, eadk8801

Online Full Text: dx.doi.org/ (Open Access)
Giuranna, Johanna; Zheng, Yiran; Brandt, Matthäus; Jall, Sigrid; Mukherjee, Amrita; Shankhwar, Soni; Renner, Simone; Kurapati, Nirup Kumar; May, Caroline; Peters, Triinu; Herpertz-Dahlmann, Beate; Seitz, Jochen; de Zwaan, Martina; Herzog, Wolfgang; Ehrlich, Stefan; Zipfel, Stephan; Giel, Katrin; Egberts, Karin; Burghardt, Roland; Föcker, Manuel; Marcus, Katrin; Keyvani, Kathy; Müller, Timo D.; Schmitz, Frank; Rajcsanyi, Luisa Sophie; Hinney, Anke

Genetic and functional analyses of CTBP2 in anorexia nervosa and body weight regulation

In: Molecular Psychiatry (2024)

Online Full Text: dx.doi.org/ (Open Access)
Bührer, Emanuel; Kicinski, Michal; Mandala, Mario; Pe, Madeline; Long, Georgina V; Atkinson, Victoria; Blank, Christian U; Haydon, Andrew; Dalle, Stéphane; Khattak, Adnan; Carlino, Matteo S; Meshcheryakov, Andrey; Sandhu, Shahneen; Puig, Susana; Schadendorf, Dirk; Jamal, Rahima; Rutkowski, Piotr; van den Eertwegh, Alfonsus J M; Coens, Corneel; Grebennik, Dmitri; Krepler, Clemens; Robert, Caroline; Eggermont, Alexander M M

Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054) : Long-term, health-related quality-of-life results from a double-blind, randomised, controlled, phase 3 trial

In: The Lancet Oncology Vol. 25 (2024) Nr. 9, pp. 1202 - 1212

Online Full Text: dx.doi.org/
Prosdocimi, Elena; Carpanese, Veronica; Todesca, Luca Matteo; Varanita, Tatiana; Bachmann, Magdalena; Festa, Margherita; Bonesso, Daniele; Perez-Verdaguer, Mireia; Carrer, Andrea; Velle, Angelo; Peruzzo, Roberta; Muccioli, Silvia; Doni, Davide; Leanza, Luigi; Costantini, Paola; Stein, Frank; Rettel, Mandy; Felipe, Antonio; Edwards, Michael J.; Gulbins, Erich; Cendron, Laura; Romualdi, Chiara; Checchetto, Vanessa; Szabo, Ildiko

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway

In: Science Advances Vol. 10 (2024) Nr. 36, eadn9361

Online Full Text: dx.doi.org/ (Open Access)
Felip, E.; Cho, B.C.; Gutiérrez, V.; Alip, A.; Besse, B.; Lu, S.; Spira, A.I.; Girard, N.; Califano, R.; Gadgeel, S.M.; Yang, J.C.-H.; Yamamoto, S.; Azuma, K.; Kim, Y.J.; Lee, K.-H.; Danchaivijitr, P.; Ferreira, C.G.; Cheng, Y.; Sendur, M.A.N.; Chang, G.-C.; Wang, C.-C.; Prabhash, K.; Shinno, Y.; Stroyakovskiy, D.; Paz-Ares, L.; Rodriguez-Cid, J.R.; Martin, C.; Campelo, M.R.G.; Hayashi, H.; Nguyen, D.; Tomasini, P.; Gottfried, M.; Dooms, C.; Passaro, A.; Schuler, Martin; Gelatti, A.C.Z.; Owen, S.; Perdrizet, K.; Ou, S.-H.I.; Curtin, J.C.; Zhang, J.; Gormley, M.; Sun, T.; Panchal, A.; Ennis, M.; Fennema, E.; Daksh, M.; Sethi, S.; Bauml, J.M.; Lee, S.-H.

Amivantamab plus lazertinib versus osimertinib in first-line EGFR-mutant advanced non-small-cell lung cancer with biomarkers of high-risk disease : a secondary analysis from MARIPOSA

In: Annals of Oncology Vol. 35 (2024) Nr. 9, pp. 805 - 816

Online Full Text: dx.doi.org/ (Open Access)
Massoni-Badosa, Ramon; Aguilar-Fernández, Sergio; Nieto, Juan C.; Soler-Vila, Paula; Elosua-Bayes, Marc; Marchese, Domenica; Kulis, Marta; Vilas-Zornoza, Amaia; Bühler, Marco Matteo; Rashmi, Sonal; Alsinet, Clara; Caratù, Ginevra; Moutinho, Catia; Ruiz, Sara; Lorden, Patricia; Lunazzi, Giulia; Colomer, Dolors; Frigola, Gerard; Blevins, Will; Romero-Rivero, Lucia; Jiménez-Martínez, Víctor; Vidal, Anna; Mateos-Jaimez, Judith; Maiques-Diaz, Alba; Ovejero, Sara; Moreaux, Jérôme; Palomino, Sara; Gomez-Cabrero, David; Agirre, Xabier; Weniger, Marc A.; King, Hamish W.; Garner, Lucy C.; Marini, Federico; Cervera-Paz, Francisco Javier; Baptista, Peter M.; Vilaseca, Isabel; Rosales, Cecilia; Ruiz-Gaspà, Silvia; Talks, Benjamin; Sidhpura, Keval; Pascual-Reguant, Anna; Hauser, Anja E.; Haniffa, Muzlifah; Prosper, Felipe; Küppers, Ralf; Gut, Ivo Glynne; Campo, Elias; Martin-Subero, José Ignacio; Heyn, Holger

An atlas of cells in the human tonsil

In: Immunity Vol. 57 (2024) Nr. 2, pp. 379 - 399.e18

Online Full Text: dx.doi.org/ (Open Access)
Anker, Markus S.; Rassaf, Tienush; Zamorano, José L.; Khan, Muhammad Shahzeb; Landmesser, Ulf

Cardiac wasting and cancer

In: European Heart Journal Vol. 45 (2024) Nr. 34, pp. 3135 - 3137

Online Full Text: dx.doi.org/ (Open Access)
George, Julie; Maas, Lukas; Abedpour, Nima; Cartolano, Maria; Kaiser, Laura; Fischer, Rieke N.; Scheel, Andreas H.; Weber, Jan-Philipp; Hellmich, Martin; Bosco, Graziella; Volz, Caroline; Mueller, Christian; Dahmen, Ilona; John, Felix; Alves, Cleidson Padua; Werr, Lisa; Panse, Jens Peter; Kirschner, Martin; Engel-Riedel, Walburga; Jürgens, Jessica; Stoelben, Erich; Brockmann, Michael; Grau, Stefan; Sebastian, Martin; Stratmann, Jan A.; Kern, Jens; Hummel, Horst-Dieter; Hegedüs, Balazs; Schuler, Martin; Plönes, Till; Aigner, Clemens; Elter, Thomas; Toepelt, Karin; Ko, Yon-Dschun; Kurz, Sylke; Grohé, Christian; Serke, Monika; Höpker, Katja; Hagmeyer, Lars; Doerr, Fabian; Hekmath, Khosro; Strapatsas, Judith; Kambartel, Karl-Otto; Chakupurakal, Geothy; Busch, Annette; Bauernfeind, Franz-Georg; Griesinger, Frank; Luers, Anne; Dirks, Wiebke; Wiewrodt, Rainer; Luecke, Andrea; Rodermann, Ernst; Diel, Andreas; Hagen, Volker; Severin, Kai; Ullrich, Roland T.; Reinhardt, Hans Christian; Quaas, Alexander; Bogus, Magdalena; Courts, Cornelius; Nürnberg, Peter; Becker, Kerstin; Achter, Viktor; Büttner, Reinhard; Wolf, Jürgen; Peifer, Martin; Thomas, Roman K.

Evolutionary trajectories of small cell lung cancer under therapy

In: Nature Vol. 627 (2024) Nr. 8005, pp. 880 - 889

Online Full Text: dx.doi.org/ (Open Access)
Tretter, Celina; de Andrade Krätzig, Niklas; Pecoraro, Matteo; Lange, Sebastian; Seifert, Philipp; von Frankenberg, Clara; Untch, Johannes; Zuleger, Gabriela; Wilhelm, Mathias; Zolg, Daniel P.; Dreyer, Florian S.; Bräunlein, Eva; Engleitner, Thomas; Uhrig, Sebastian; Boxberg, Melanie; Steiger, Katja; Slotta-Huspenina, Julia; Ochsenreither, Sebastian; von Bubnoff, Nikolas; Bauer, Sebastian; Boerries, Melanie; Jost, Philipp J.; Schenck, Kristina; Dresing, Iska; Bassermann, Florian; Friess, Helmut; Reim, Daniel; Grützmann, Konrad; Pfütze, Katrin; Klink, Barbara; Schröck, Evelin; Haller, Bernhard; Kuster, Bernhard; Mann, Matthias; Weichert, Wilko; Fröhling, Stefan; Rad, Roland; Hiltensperger, Michael; Krackhardt, Angela M.

Correction to: Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification

In: Nature Communications Vol. 15 (2024) Nr. 1, 2364

Online Full Text: dx.doi.org/ (Open Access)
Messmer, Julia M.; Thommek, Calvin; Piechutta, Manuel; Venkataramani, Varun; Wehner, Rebekka; Westphal, Dana; Schubert, Marc; Mayer, Chanté D.; Effern, Maike; Berghoff, Anna S.; Hinze, Daniel; Helfrich, Iris; Schadendorf, Dirk; Wick, Wolfgang; Hölzel, Michael; Karreman, Matthia A.; Winkler, Frank

T lymphocyte recruitment to melanoma brain tumors depends on distinct venous vessels

In: Immunity (2024) in press

Online Full Text: dx.doi.org/ (Open Access)
Karpinski, Madeleine J; Hüsing, Johannes; Claassen, Kevin; Möller, Lennart; Kajüter, Hiltraud; Oesterling, Florian; Grünwald, Viktor; Umutlu, Lale; Kleesiek, Jens; Telli, Tugce; Merkel-Jens, Anja; Hüsing, Anika; Kesch, Claudia; Herrmann, Ken; Eiber, Matthias; Hoberück, Sebastian; Meyer, Philipp T; Kind, Felix; Rahbar, Kambiz; Schäfers, Michael; Stang, Andreas; Hadaschik, Boris A.; Fendler, Wolfgang P.

Combining PSMA-PET and PROMISE to re-define disease stage and risk in patients with prostate cancer : A multicentre retrospective study

In: The Lancet Oncology Vol. 25 (2024) Nr. 9, pp. 1188 - 1201

Online Full Text: dx.doi.org/ (Open Access)
Desch, Steffen; Zeymer, Uwe; Akin, Ibrahim; Behnes, Michael; Duerschmied, Daniel; Rassaf, Tienush; Mahabadi, Amir Abbas; Lehmann, Ralf; Eitel, Ingo; Graf, Tobias; Seidler, Tim; Schuster, Andreas; Thevathasan, Tharusan; Skurk, Carsten; Clemmensen, Peter; Hennersdorf, Marcus; Fichtlscherer, Stephan; Voigt, Ingo; Seyfarth, Melchior; John, Stefan; Ewen, Sebastian; Linke, Axel; Tigges, Eike; Nordbeck, Peter; Bruch, Leonhard; Jung, Christian; Franz, Jutta; Lauten, Philipp; Noc, Marko; Fuernau, Georg; Feistritzer, Hans-Josef; Pöss, Janine; Kirchhof, Eva; Ouarrak, Taoufik; Schneider, Steffen; Freund, Anne; Thiele, Holger

Routine extracorporeal life support in infarct-related cardiogenic shock : 1-year results of the ECLS-SHOCK trial

In: European Heart Journal Vol. 45 (2024) Nr. 39, pp. 4200 - 4203

Online Full Text: dx.doi.org/ (Open Access)
Singh, Simron; Halperin, Daniel; Myrehaug, Sten; Herrmann, Ken; Pavel, Marianne; Kunz, Pamela L; Chasen, Beth; Tafuto, Salvatore; Lastoria, Secondo; Capdevila, Jaume; García-Burillo, Amparo; Oh, Do-Youn; Yoo, Changhoon; Halfdanarson, Thorvardur R; Falk, Stephen; Folitar, Ilya; Zhang, Yufen; Aimone, Paola; de Herder, Wouter W; Ferone, Diego

[¹⁷⁷Lu]Lu-DOTA-TATE plus long-acting octreotide versus high‑dose long-acting octreotide for the treatment of newly diagnosed, advanced grade 2–3, well-differentiated, gastroenteropancreatic neuroendocrine tumours (NETTER-2) : an open-label, randomised, phase 3 study

In: Lancet Vol. 403 (2024) Nr. 10446, pp. 2807 - 2817

Online Full Text: dx.doi.org/
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Neoadjuvant nivolumab with or without relatlimab in resectable non-small-cell lung cancer : A randomized phase 2 trial

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Scrutinizing the Role of Venoarterial Extracorporeal Membrane Oxygenation : Has Clinical Practice Outpaced the Evidence?

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Knittel, Gero; Reinhardt, Hans Christian

XPO1-Mediated mRNA Export of Genome Maintenance Regulators Drives Chemotherapy Resistance in Aggressive Lymphoma

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Ripretinib versus sunitinib in gastrointestinal stromal tumor : ctDNA biomarker analysis of the phase 3 INTRIGUE trial

In: Nature Medicine Vol. 30 (2024) Nr. 2, pp. 498 - 506

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Vimseltinib versus placebo for tenosynovial giant cell tumour (MOTION) : a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

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2023

Berger, Marc; Brenner, Thorsten; Hinney, Anke; Witzke, Oliver; Konik, Margarethe; The COVID-19 Host Genetics Initiative

A second update on mapping the human genetic architecture of COVID-19

In: Nature Vol. 621 (2023) pp. E7 - E26

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Weischenfeldt, Joachim; Beroukhim, Rameen; Martincorena, Iñigo; Küppers, Ralf

Author Correction : Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

In: Nature Vol. 614 (2023) pp. E40

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Gerstung, Moritz; Jolly, Clemency; Leshchiner, Ignaty; Küppers, Ralf; Schadendorf, Dirk

Author Correction : The evolutionary history of 2,658 cancers

In: Nature Vol. 614 (2023) pp. E42

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Yakneen, Sergei; M. Waszak, Sebastian; Korbel, Jan O.; Küppers, Ralf; Schadendorf, Dirk

Author Correction : Butler enables rapid cloud-based analysis of thousands of human genomes

In: Nature Biotechnology Vol. 41 (2023) Nr. 4, pp. 577

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Weischenfeldt, Joachim; Beroukhim, Rameen; Martincorena, Iñigo; Küppers, Ralf; Schadendorf, Dirk

Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

In: Nature Vol. 578 (2023) Nr. 7793, pp. 102 - 111

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Weischenfeldt, Joachim; Beroukhim, Rameen; Campbell, Peter J.; Küppers, Ralf; Schadendorf, Dirk

Author Correction : Patterns of somatic structural variation in human cancer genomes

In: Nature Vol. 614 (2023) Nr. 7948, pp. E38

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A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma

In: Clinical Cancer Research Vol. 29 (2023) Nr. 2, pp. 488 - 500

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Calabrese, Claudia; Brazma, Alvis; Brooks, Angela N.; Rätsch, Gunnar; Küppers, Ralf; Schadendorf, Dirk

Author Correction : Genomic basis for RNA alterations in cancer

In: Nature Vol. 614 (2023) Nr. 7948, pp. E37

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Alexandrov, Ludmil B.; Kim, Jaegil; Haradhvala, Nicholas J.; Rozen, Steven G.; Stratton, Michael R.; Küppers, Ralf; Schadendorf, Dirk

Author Correction: : The repertoire of mutational signatures in human cancer

In: Nature Vol. 614 (2023) pp. E41

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Yuan, Yuan; Küppers, Ralf; Schadendorf, Dirk; Park, Keunchil; Campbell, Peter J.; Liang, Han

Comprehensive molecular characterization of mitochondrial genomes in human cancers

In: Nature Genetics Vol. 52 (2023) pp. 342 - 352

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Akdemir, Kadir C.; Küppers, Ralf; Schadendorf, Dirk; Futreal, P. Andrew

Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

In: Nature Genetics Vol. 55 (2023) Nr. 6, pp. 1079

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ComplexEye : a multi-lens array microscope for high-throughput embedded immune cell migration analysis

In: Nature Communications Vol. 14 (2023) Nr. 1, 8103

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Yuan, Yuan; Küppers, Ralf; Schadendorf, Dirk; Park, Keunchil; Campbell, Peter J.; Liang, Han

Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers

In: Nature Genetics Vol. 55 (2023) Nr. 6, pp. 1078

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Rodriguez-Martin, Bernardo; Schadendorf, Dirk; Küppers, Ralf; Campbell, Peter J.

Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

In: Nature Genetics Vol. 55 (2023) Nr. 6, 1080

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Zapatka, Marc; Schadendorf, Dirk; Lichter, Peter

Author Correction: The landscape of viral associations in human cancers

In: Nature Genetics Vol. 55 (2023) Nr. 6, pp. 1077

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Cortés-Ciriano, Isidro; Küppers, Ralf; Schadendorf, Dirk; Park, Peter J.

Author Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

In: Nature Genetics Vol. 55 (2023) Nr. 6, 1076

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Cortés-Ciriano, Isidro; Küppers, Ralf; Schadendorf, Dirk; Park, Peter J.

Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

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Data-driven grading of acute graft-versus-host disease

In: Nature Communications Vol. 14 (2023) Nr. 1, 7799

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Coinhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills pancreatic cancer via readthrough transcription

In: Science Advances Vol. 9 (2023) Nr. 41, eadg5109

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Zoledronic Acid Add-on Therapy for Standard-Risk Ewing Sarcoma Patients in the Ewing 2008R1 Trial

In: Clinical Cancer Research Vol. 29 (2023) Nr. 24, pp. 5057 - 5068

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Decrypting drug actions and protein modifications by dose- and time-resolved proteomics

In: Science Vol. 380 (2023) Nr. 6640, pp. 93 - 101

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Integrative multi-omics reveals two biologically distinct groups of pilocytic astrocytoma

In: Acta Neuropathologica Vol. 149 (2023) Nr. 4, pp. 551 - 564

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Extracorporeal Life Support in Infarct-Related Cardiogenic Shock

In: The New England Journal of Medicine Vol. 389 (2023) Nr. 14, pp. 1286 - 1297

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Erdafitinib in patients with advanced solid tumours with FGFR alterations (RAGNAR) : An international, single-arm, phase 2 study

In: The Lancet Oncology Vol. 24 (2023) Nr. 8, pp. 925 - 935

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Adjuvant immunotherapy with nivolumab versus observation in completely resected Merkel cell carcinoma (ADMEC-O) : disease-free survival results from a randomised, open-label, phase 2 trial

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Germ line variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapy

In: Blood Vol. 142 (2023) Nr. 25, pp. 2175 - 2191

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The hypoxia-regulated ectonucleotidase CD73 is a host determinant of HIV latency

In: Cell Reports Vol. 42 (2023) Nr. 11, 113285

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Single-cell analysis of memory B cells from top neutralizers reveals multiple sites of vulnerability within HCMV Trimer and Pentamer

In: Immunity Vol. 56 (2023) Nr. 11, pp. 2602 - 2620.e10

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KIT and PDGFRA Mutations and Survival of Gastrointestinal Stromal Tumor Patients Treated with Adjuvant Imatinib in a Randomized Trial

In: Clinical Cancer Research Vol. 29 (2023) Nr. 17, pp. 3313 - 3319

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Transcriptional reprogramming by mutated IRF4 in lymphoma

In: Nature Communications Vol. 14 (2023) Nr. 1, 6947

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Rodriguez-Martin, Bernardo; Schadendorf, Dirk; Küppers, Ralf; Campbell, Peter J.

Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

In: Nature Genetics Vol. 52 (2023) Nr. 3, pp. 306 - 319

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Designing clinical trials based on modern imaging and metastasis-directed treatments in patients with oligometastatic breast cancer : a consensus recommendation from the EORTC Imaging and Breast Cancer Groups

In: The Lancet Oncology Vol. 24 (2023) Nr. 8, pp. e331 - e343

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HLA class II loss and JAK1/2 deficiency coevolve in melanoma leading to CD4 T cell and IFNγ cross-resistance

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Allogeneic hematopoietic stem cell transplantation for NK/T-cell lymphoma : An international collaborative analysis

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Circulating tumor DNA analysis of the phase III VOYAGER trial : KIT mutational landscape and outcomes in patients with advanced gastrointestinal stromal tumor treated with avapritinib or regorafenib

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Health-related quality of life and pain outcomes with [¹⁷⁷Lu]Lu-PSMA-617 plus standard of care versus standard of care in patients with metastatic castration-resistant prostate cancer (VISION) : a multicentre, open-label, randomised, phase 3 trial

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Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses

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Hemizygous CDKN2A deletion confers worse survival outcomes in IDHmut-noncodel gliomas

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N1 versus N2 and PMN-MDSC : A critical appraisal of current concepts on tumor-associated neutrophils and new directions for human oncology

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Next generation radiotheranostics promoting precision medicine

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Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesis

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The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity

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The German Network for Personalized Medicine to enhance patient care and translational research

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Neoadjuvant immunotherapy for melanoma is now ready for clinical practice

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Impact of TP53 on outcome of patients with myelofibrosis undergoing hematopoietic stem cell transplantation

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The transcriptional and regulatory identity of erythropoietin producing cells

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Interactive enhancer hubs (iHUBs) mediate transcriptional reprogramming and adaptive resistance in pancreatic cancer

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Neutrophil Conversion to a Tumor-Killing Phenotype Underpins Effective Microbial Therapy

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Active Remodeling of Capillary Endothelium via Cancer Cell-Derived MMP9 Promotes Metastatic Brain Colonization

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The repertoire of mutational signatures in human cancer

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Optimizing platelet transfusion through a personalized deep learning risk assessment system for demand management

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LAMC2 Regulates Key Transcriptional and Targetable Effectors to Support Pancreatic Cancer Growth

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Neoadjuvant cemiplimab and surgery for stage II–IV cutaneous squamous-cell carcinoma : follow-up and survival outcomes of a single-arm, multicentre, phase 2 study

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Patterns of somatic structural variation in human cancer genomes

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Genomic basis for RNA alterations in cancer

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Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer

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Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

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Impaired humoral immunity to BQ.1.1 in convalescent and vaccinated patients

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Individual glioblastoma cells harbor both proliferative and invasive capabilities during tumor progression

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Molecular heterogeneity and commonalities in pancreatic cancer precursors with gastric and intestinal phenotype

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Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification

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Resting natural killer cell homeostasis relies on tryptophan/NAD⁺ metabolism and HIF-1α

In: EMBO Reports (2023) e56156

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The landscape of viral associations in human cancers

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Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer’s disease

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Sotorasib in KRAS p.G12C-Mutated Advanced Pancreatic Cancer

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Author Correction: Pan-cancer analysis of whole genomes

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Sotorasib versus docetaxel for previously treated non-small-cell lung cancer with KRASG¹²C mutation : a randomised, open-label, phase 3 trial

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Spinal astrocyte dysfunction drives motor neuron loss in late-onset spinal muscular atrophy

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2022

Küppers, Ralf; Schadendorf, Dirk; Creighton, Chad J.; PCAWG Consortium

Author Correction : High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations

In: Nature Communications Vol. 13 (2022) 7572

Online Full Text: dx.doi.org/ (Open Access)
Küppers, Ralf; Schadendorf, Dirk; Reimand, Jüri; PCAWG Consortium

Author Correction : Pathway and network analysis of more than 2500 whole cancer genomes

In: Nature Communications Vol. 13 (2022) 7566

Online Full Text: dx.doi.org/ (Open Access)
Küppers, Ralf; Schadendorf, Dirk; Morris, Quaid D.; PCAWG Consortium

Author Correction : Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig

In: Nature Communications Vol. 13 (2022) 7567

Online Full Text: dx.doi.org/ (Open Access)
Küppers, Ralf; Schadendorf, Dirk; Bristow, Robert G.; Boutros, Paul C.; PCAWG Consortium

Author Correction : Divergent mutational processes distinguish hypoxic and normoxic tumours

In: Nature Communications Vol. 13 (2022) 7569

Online Full Text: dx.doi.org/ (Open Access)
Küppers, Ralf; Schadendorf, Dirk; Shuai, Shimin; Stein, Lincoln D.; PCAWG Drivers and Functional Interpretation Working Group; PCAWG Consortium

Author Correction : Combined burden and functional impact tests for cancer driver discovery using DriverPower

In: Nature Communications Vol. 13 (2022) 7571

Online Full Text: dx.doi.org/ (Open Access)
Küppers, Ralf; Schadendorf, Dirk; Stein, Lincoln D.; PCAWG Consortium

Author Correction : A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

In: Nature Communications Vol. 13 (2022) 7573

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Consensus Statement on Mandatory Measurements for Pancreatic Cancer Trials for Patients with Resectable or Borderline Resectable Disease (COMM-PACT-RB) : A Systematic Review and Delphi Consensus Statement

In: JAMA Oncology Vol. 8 (2022) Nr. 6, pp. 929 - 937

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Adjuvant Imatinib in Patients with GIST Harboring Exon 9 KIT Mutations : Results from a Multi-institutional European Retrospective Study

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ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury

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Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma (KEYNOTE-716) : distant metastasis-free survival results of a multicentre, double-blind, randomised, phase 3 trial

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Haplo-PtCy : Adjusting the HLA barrier

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Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries

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Author Correction : Integrative pathway enrichment analysis of multivariate omics data

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Cell-intrinsic ceramides determine T cell function during melanoma progression

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Deregulation and epigenetic modification of BCL2-family genes cause resistance to venetoclax in hematologic malignancies

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Author Correction : Inferring structural variant cancer cell fraction

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Author Correction : Genomic footprints of activated telomere maintenance mechanisms in cancer

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B cell expansion hinders the stroma-epithelium regenerative cross talk during mucosal healing

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Persister state-directed transitioning and vulnerability in melanoma
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Results from a First-in-Human Phase I Study of Siremadlin (HDM201) in Patients with Advanced Wild-Type TP53 Solid Tumors and Acute Leukemia

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SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma

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CTLA-4 Blockade Resistance after Relatlimab and Nivolumab

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Safety and Efficacy of 90Y-FAPI-46 Radioligand Therapy in Patients with Advanced Sarcoma and Other Cancer Entities

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Enhancing Radioiodine Incorporation into Radioiodine-Refractory Thyroid Cancer with MAPK Inhibition (ERRITI) : A Single-Center Prospective Two-Arm Study

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Interim FDG-PET analysis to identify patients with aggressive non-Hodgkin lymphoma who benefit from treatment intensification : A post-hoc analysis of the PETAL trial

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Practical Considerations for the Use of Circulating Tumor DNA in the Treatment of Patients With Cancer

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Stroke genetics informs drug discovery and risk prediction across ancestries

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Adjuvant nivolumab plus ipilimumab or nivolumab alone versus placebo in patients with resected stage IV melanoma with no evidence of disease (IMMUNED) : Final results of a randomised, double-blind, phase 2 trial

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Comprehensive cancer predisposition testing within the prospective MASTER trial identifies hereditary cancer patients and supports treatment decisions for rare cancers

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The acid ceramidase/ceramide axis controls parasitemia in Plasmodium yoelii-infected mice by regulating erythropoiesis

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The alarmin interleukin-1α triggers secondary degeneration through reactive astrocytes and endothelium after spinal cord injury

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MCU controls melanoma progression through a redox-controlled phenotype switch

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Aberrant expansion of spontaneous splenic germinal centers induced by hallmark genetic lesions of aggressive lymphoma

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The RUHR Heart Failure Network : Improved heart failure care in a metropolitan area

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3D structure and in situ arrangements of CatSper channel in the sperm flagellum

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Extracellular vesicles and PD-L1 suppress macrophages, inducing therapy resistance in TP53-deficient B-cell malignancies

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Co-Targeting of MDM2 and CDK4/6 with Siremadlin and Ribociclib for the Treatment of Patients with Well-Differentiated or Dedifferentiated Liposarcoma : Results from a Proof-of-Concept, Phase Ib Study

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A core group of structurally similar HLA-DPB1 alleles drives permissiveness after hematopoietic cell transplantation

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20-Year Steady Increase in Survival of Adult Patients with Relapsed Philadelphia-Positive Acute Lymphoblastic Leukemia Post Allogeneic Hematopoietic Cell Transplantation

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During early stages of cancer, neutrophils initiate anti-tumor immune responses in tumor-draining lymph nodes

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Pan-cancer efficacy of pralsetinib in patients with RET fusion–positive solid tumors from the phase 1/2 ARROW trial

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C11orf94/Frey is a key regulator for male fertility by controlling Izumo1 complex assembly

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Cardiotoxicity from chimeric antigen receptor-T cell therapy for advanced malignancies

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Treatment outcome of atypical EGFR mutations in the German National Network Genomic Medicine Lung Cancer (nNGM)

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Targeting early stages of cardiotoxicity from anti-PD1 immune checkpoint inhibitor therapy

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BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment

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Stroke induces disease-specific myeloid cells in the brain parenchyma and pia

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Bartl, Jasmin; Zanini, Marco; Bernardi, Flavia; Forget, Antoine; Blümel, Lena; Talbot, Julie; Picard, Daniel; Qin, Nan; Cancila, Gabriele; Gao, Qingsong; Nath, Soumav; Koumba, Idriss Mahoungou; Wolter, Marietta; Kuonen, François; Langini, Maike; Beez, Thomas; Munoz, Christopher; Pauck, David; Marquardt, Viktoria; Yu, Hua; Souphron, Judith; Korsch, Mascha; Mölders, Christina; Berger, Daniel; Göbbels, Sarah; Meyer, Frauke-Dorothee; Scheffler, Björn; Rotblat, Barak; Diederichs, Sven; Ramaswamy, Vijay; Suzuki, Hiromishi; Oro, Anthony; Stühler, Kai; Stefanski, Anja; Fischer, Ute; Leprivier, Gabriel; Willbold, Dieter; Steger, Gerhard; Buell, Alexander; Kool, Marcel; Lichter, Peter; Pfister, Stefan M.; Northcott, Paul A.; Taylor, Michael D.; Borkhardt, Arndt; Reifenberger, Guido; Ayrault, Olivier; Remke, Marc

The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors

In: Nature Communications Vol. 13 (2022) Nr. 1, 4061

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Schuler, Martin; Zimmer, Lisa; Kim, Kevin B.; Sosman, Jeffrey A.; Ascierto, Paolo A.; Postow, Michael A.; De Vos, Filip Y.F.L.; van Herpen, Carla M.L.; Carlino, Matteo S.; Johnson, Douglas B.; Berking, Carola; Reddy, Micaela B.; Harney, Allison S.; Berlin, Jordan D.; Amaria, Rodabe N.

Phase Ib/II Trial of Ribociclib in Combination with Binimetinib in Patients with NRAS-mutant Melanoma

In: Clinical Cancer Research Vol. 28 (2022) Nr. 14, pp. 3002 - 3010

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Schniewind, Iñaki; Hadiwikarta, Wahyu Wijaya; Grajek, Julia; Poleszczuk, Jan; Richter, Susan; Peitzsch, Mirko; Müller, Johannes; Klusa, Daria; Beyreuther, Elke; Löck, Steffen; Lühr, Armin; Frosch, Susanne; Groeben, Christer; Sommer, Ulrich; Krause, Mechthild; Dubrovska, Anna; von Neubeck, Cläre; Kurth, Ina; Peitzsch, Claudia

Cellular plasticity upon proton irradiation determines tumor cell radiosensitivity

In: Cell Reports Vol. 38 (2022) Nr. 8, 110422

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Schirrmann, Ronja; Erkelenz, Michael; Lamers, Kim; Sritharan, Oliver; Nachev, Milen; Sures, Bernd; Schlücker, Sebastian; Brandau, Sven

Gold Nanorods Induce Endoplasmic Reticulum Stress and Autocrine Inflammatory Activation in Human Neutrophils

In: ACS Nano Vol. 16 (2022) Nr. 7, pp. 11011 - 11026

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Gross, Neil D.; Miller, David M.; Khushalani, Nikhil I.; Divi, Vasu; Ruiz, Emily S.; Lipson, Evan J.; Meier, Friedegund; Su, Yungpo B.; Swiecicki, Paul L.; Atlas, Jennifer; Geiger, Jessica L.; Hauschild, Axel; Choe, Jennifer H.; Hughes, Brett G.M.; Schadendorf, Dirk; Patel, Vishal A.; Homsi, Jade; Taube, Janis M.; Lim, Annette M.; Ferrarotto, Renata; Kaufman, Howard L.; Seebach, Frank; Lowy, Israel; Yoo, Suk-Young; Mathias, Melissa; Fenech, Keilah; Han, Hyunsil; Fury, Matthew G.; Rischin, Danny

Neoadjuvant Cemiplimab for Stage II to IV Cutaneous Squamous-Cell Carcinoma

In: The New England Journal of Medicine Vol. 387 (2022) Nr. 17, pp. 1557 - 1568

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Luke, Jason J.; Rutkowski, Piotr; Queirolo, Paola; Del Vecchio, Michele; Mackiewicz, Jacek; Chiarion-Sileni, Vanna; de la Cruz Merino, Luis; Khattak, Muhammad A.; Schadendorf, Dirk; Long, Georgina V.; Ascierto, Paolo A.; Mandala, Mario; De Galitiis, Federica; Haydon, Andrew; Dummer, Reinhard; Grob, Jean-Jacques; Robert, Caroline; Carlino, Matteo S.; Mohr, Peter; Poklepovic, Andrew; Sondak, Vernon K.; Scolyer, Richard A.; Kirkwood, John M.; Chen, Ke; Diede, Scott J.; Ahsan, Sama; Ibrahim, Nageatte; Eggermont, Alexander M. M.

Pembrolizumab versus placebo as adjuvant therapy in completely resected stage IIB or IIC melanoma (KEYNOTE-716) : a randomised, double-blind, phase 3 trial

In: Lancet Vol. 399 (2022) Nr. 10336, pp. 1718 - 1729

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Cheung, Phyllis F.; Yang, JiaJin; Fang, Rui; Borgers, Arianna; Krengel, Kirsten; Stoffel, Anne; Althoff, Kristina; Yip, Chi Wai; Siu, Elaine H. L.; Ng, Linda W. C.; Lang, Karl S.; Cham, Lamin B.; Engel, Daniel Robert; Soun, Camille; Cima, Igor; Scheffler, Björn; Striefler, Jana K.; Sinn, Marianne; Bahra, Marcus; Pelzer, Uwe; Oettle, Helmut; Markus, Peter; Smeets, Esther M. M.; Aarntzen, Erik H. J. G.; Savvatakis, Konstantinos; Liffers, Sven-Thorsten; Lueong, Smiths S.; Neander, Christian; Bazarna, Anna; Zhang, Xin; Paschen, Annette; Crawford, Howard C.; Chan, Anthony W. H.; Cheung, Siu Tim; Siveke, Jens

Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression

In: Nature Communications Vol. 13 (2022) Nr. 1, 156

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Zeng, Ni; Capelle, Christophe M.; Baron, Alexandre; Kobayashi, Takumi; Cire, Severine; Tslaf, Vera; Leonard, Cathy; Coowar, Djalil; Koseki, Haruhiko; Westendorf, Astrid; Buer, Jan; Brenner, Dirk; Krüger, Rejko; Balling, Rudi; Ollert, Markus; Hefeng, Feng Q.

DJ-1 depletion prevents immunoaging in T-cell compartments

In: EMBO Reports Vol. 23 (2022) Nr. 3, e53302

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Tawbi, Hussein A.; Schadendorf, Dirk; Lipson, Evan J.; Ascierto, Paolo A.; Matamala, Luis; Castillo Gutiérrez, Erika; Rutkowski, Piotr; Gogas, Helen J.; Lao, Christopher D.; De Menezes, Juliana Janoski; Dalle, Stéphane; Arance, Ana; Grob, Jean-Jacques; Srivastava, Shivani; Abaskharoun, Mena; Hamilton, Melissa; Keidel, Sarah; Simonsen, Katy L.; Sobiesk, Anne Marie; Li, Bin; Hodi, F. Stephen; Long, Georgina V.

Relatlimab and Nivolumab versus Nivolumab in Untreated Advanced Melanoma

In: The New England Journal of Medicine Vol. 386 (2022) Nr. 1, pp. 24 - 34

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Hoertel, Nicolas; Sánchez-Rico, Marina; Herrera-Morueco, Juan José; de la Muela, Pedro; Gulbins, Erich; Kornhuber, Johannes; Carpinteiro, Alexander; Becker-Flegler, Katrin; Cougoule, Céline; Limosin, Frédéric

Comorbid medical conditions are a key factor to understand the relationship between psychiatric disorders and COVID-19-related mortality : Results from 49,089 COVID-19 inpatients

In: Molecular Psychiatry Vol. 27 (2022) Nr. 3, pp. 1278 - 1280

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Gastrointestinal stromal tumours : ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up

In: Annals of Oncology Vol. 33 (2022) Nr. 1, pp. 20 - 33

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Preneoplastic somatic mutations including MYD88L²⁶⁵P in lymphoplasmacytic lymphoma

In: Science Advances Vol. 8 (2022) Nr. 3, eabl4644

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Grüneboom, Anika; Aust, Oliver; Cibir, Zülal; Weber, Flora; Hermann, Dirk M.; Gunzer, Matthias

Imaging innate immunity*

In: Immunological Reviews Vol. 306 (2022) Nr. 1, pp. 293 - 303

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Leypoldt, Lisa B.; Besemer, Britta; Asemissen, Anne Marie; Hänel, Mathias; Blau, Igor Wolfgang; Görner, Martin; Ko, Yon-Dschun; Reinhardt, Christian; Staib, Peter; Mann, Christoph; Lutz, Raphael; Munder, Markus; Graeven, Ullrich; Peceny, Rudolf; Salwender, Hans; Jauch, Anna; Zago, Manola; Benner, Axel; Tichy, Diana; Bokemeyer, Carsten; Goldschmidt, Hartmut; Weisel, Katja C.

Isatuximab, carfilzomib, lenalidomide, and dexamethasone (Isa-KRd) in front-line treatment of high-risk multiple myeloma : Interim analysis of the GMMG-CONCEPT trial

In: Leukemia Vol. 36 (2022) Nr. 3, pp. 885 - 888

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Kornhuber, Johannes; Hoertel, Nicolas; Gulbins, Erich

The acid sphingomyelinase/ceramide system in COVID-19

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2021

Flümann, Ruth; Rehkämper, Tim; Nieper, Pascal; Pfeiffer, Pauline; Holzem, Alessandra; Klein, Sebastian; Bhatia, Sanil; Kochanek, Moritz; Kisis, Ilmars; Pelzer, Benedikt W.; Ahlert, Heinz; Hauer, Julia; da Palma Guerreiro, Alexandra; Ryan, Jeremy A.; Reimann, Maurice; Riabinska, Arina; Wiederstein, Janica; Krüger, Marcus; Deckert, Martina; Altmüller, Janine; Klatt, Andreas R.; Frenzel, Lukas P.; Pasqualucci, Laura; Béguelin, Wendy; Melnick, Ari M.; Sander, Sandrine; Montesinos-Rongen, Manuel; Brunn, Anna; Lohneis, Philipp; Büttner, Reinhard; Kashkar, Hamid; Borkhardt, Arndt; Letai, Anthony; Persigehl, Thorsten; Peifer, Martin; Schmitt, Clemens A.; Reinhardt, Christian; Knittel, Gero

An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities

In: Cancer Discovery Vol. 2 (2021) Nr. 1, pp. 70 - 91

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Clinical Activity of Ripretinib in Patients with Advanced Gastrointestinal Stromal Tumor Harboring Heterogeneous KIT/PDGFRA Mutations in the Phase III INVICTUS Study

In: Clinical Cancer Research Vol. 27 (2021) Nr. 23, pp. 6333 - 6342

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Bone sarcomas : ESMO–EURACAN–GENTURIS–ERN PaedCan Clinical Practice Guideline for diagnosis, treatment and follow-up

In: Annals of Oncology Vol. 32 (2021) Nr. 12, pp. 1520 - 1536

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Horak, Peter; Heining, Christoph; Kreutzfeldt, Simon; Hutter, Barbara; Mock, Andreas; Hüllein, Jennifer; Fröhlich, Martina; Uhrig, Sebastian; Jahn, Arne; Rump, Andreas; Gieldon, Laura; Möhrmann, Lino; Hanf, Dorothea; Teleanu, Veronica; Heilig, Christoph E.; Lipka, Daniel B.; Allgäuer, Michael; Ruhnke, Leo; Laßmann, Andreas; Endris, Volker; Neumann, Olaf; Penzel, Roland; Beck, Katja; Richter, Daniela; Winter, Ulrike; Wolf, Stephan; Pfütze, Katrin; Geörg, Christina; Meißburger, Bettina; Buchhalter, Ivo; Augustin, Marinela; Aulitzky, Walter E.; Hohenberger, Peter; Kroiss, Matthias; Schirmacher, Peter; Schlenk, Richard F.; Keilholz, Ulrich; Klauschen, Frederick; Folprecht, Gunnar; Bauer, Sebastian; Siveke, Jens; Brandts, Christian H.; Kindler, Thomas; Boerries, Melanie; Illert, Anna L.; von Bubnoff, Nikolas; Jost, Philipp J.; Spiekermann, Karsten; Bitzer, Michael; Schulze-Osthoff, Klaus; von Kalle, Christof; Klink, Barbara; Brors, Benedikt; Stenzinger, Albrecht; Schröck, Evelin; Hübschmann, Daniel; Weichert, Wilko; Glimm, Hanno; Fröhling, Stefan

Comprehensive Genomic and Transcriptomic Analysis for Guiding Therapeutic Decisions in Patients with Rare Cancers

In: Cancer Discovery Vol. 11 (2021) Nr. 11, pp. 2780 - 2795

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Le Rhun, E.; Guckenberger, M.; Smits, M.; Dummer, R.; Bachelot, T.; Sahm, F.; Galldiks, N.; de Azambuja, E.; Berghoff, A.S.; Metellus, P.; Peters, S.; Hong, Y.-K.; Winkler, F.; Schadendorf, Dirk; van den Bent, M.; Seoane, J.; Stahel, R.; Minniti, G.; Wesseling, P.; Weller, M.; Preusser, M.

EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumours

In: Annals of Oncology Vol. 32 (2021) Nr. 11, pp. 1332 - 1347

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Reimann, Maurice; Schrezenmeier, Jens; Richter-Pechanska, Paulina; Dolnik, Anna; Hick, Timon Pablo; Schleich, Kolja; Cai, Xiurong; Fan, Dorothy N. Y.; Lohneis, Philipp; Maßwig, Sven; Denker, Sophy; Busse, Antonia; Knittel, Gero; Flümann, Ruth; Childs, Dorothee; Childs, Liam; Gätjens-Sanchez, Ana-Maria; Bullinger, Lars; Rosenwald, Andreas; Reinhardt, Christian; Schmitt, Clemens A.

Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomas

In: Blood Vol. 137 (2021) Nr. 20, pp. 2785 - 2799

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Berger, Marc; Brenner, Thorsten; Hinney, Anke; Witzke, Oliver

Mapping the human genetic architecture of COVID-19

In: Nature Vol. 600 (2021) pp. 472 - 477

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Dorsch, Madeleine; Kowalczyk, Manuela; Planque, Mélanie; Heilmann, Geronimo; Urban, Sebastian; Dujardin, Philip; Forster, Jan; Ueffing, Kristina; Nothdurft, Silke; Oeck, Sebastian; Paul, Annika; Liffers, Sven T.; Kaschani, Farnusch; Kaiser, Markus; Schramm, Alexander; Siveke, Jens; Winslow, Monte M.; Fendt, Sarah-Maria; Nalbant, Perihan; Grüner, Barbara M.

Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis

In: Cell Reports Vol. 37 (2021) Nr. 8, 110056

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Wey, Karolin; Schirrmann, Ronja; Diesing, Detlef; Lang, Stephan; Brandau, Sven; Hansen, Stefan; Epple, Matthias

Coating of cochlear implant electrodes with bioactive DNA-loaded calcium phosphate nanoparticles for the local transfection of stimulatory proteins

In: Biomaterials Vol. 276 (2021)

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Abel, Frederik; Giebel, Bernd; Frey, Ulrich H.

Agony of choice : How anesthetics affect the composition and function of extracellular vesicles

In: Advanced Drug Delivery Reviews Vol. 175 (2021) 113813

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Lutetium-177-PSMA-617 for Metastatic Castration-Resistant Prostate Cancer

In: The New England Journal of Medicine Vol. 385 (2021) pp. 1091 - 1103

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Nguyen, Tan-Trieu; Ramsay, Lee Ann; Ahanfeshar-Adams, Mozhdeh; Lajoie, Mathieu; Schadendorf, Dirk; Alain, Tommy; Watson, Ian R.

Mutations in the IFNγ-JAK-STAT pathway causing resistance to immune checkpoint inhibitors in melanoma increase sensitivity to oncolytic virus treatment

In: Clinical Cancer Research Vol. 27 (2021) Nr. 12, pp. 3432 - 3442

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Kienle, Korbinian; Glaser, Katharina M.; Eickhoff, Sarah; Mihlan, Michael; Knöpper, Konrad; Reátegui, Eduardo; Epple, Maximilian W.; Gunzer, Matthias; Baumeister, Ralf; Tarrant, Teresa K.; Germain, Ronald N.; Irimia, Daniel; Kastenmüller, Wolfgang; Lämmermann, Tim

Neutrophils self-limit swarming to contain bacterial growth in vivo

In: Science Vol. 372 (2021) Nr. 6548,

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Kalinichenko, Liubov S.; Mühle, Christiane; Jia, Tianye; Anderheiden, Felix; Datz, Maria; Eberle, Anna-Lisa; Eulenburg, Volker; Granzow, Jonas; Hofer, Martin; Hohenschild, Julia; Huber, Sabine E.; Kämpf, Stefanie; Kogias, Georgios; Lacatusu, Laura; Lugmair, Charlotte; Taku, Stephen Mbu; Meixner, Doris; Tesch, Nina; Praetner, Marc; Rhein, Cosima; Sauer, Christina; Scholz, Jessica; Ulrich, Franziska; Valenta, Florian; Weigand, Esther; Werner, Markus; Tay, Nicole; Mc Veigh, Conor J.; Haase, Jana; Wang, An-Li; Abdel-Hafiz, Laila; Huston, Joseph P.; Smaga, Irena; Frankowska, Malgorzata; Filip, Malgorzata; Lourdusamy, Anbarasu; Kirchner, Philipp; Ekici, Arif B.; Marx, Lena M.; Suresh, Neeraja Puliparambil; Frischknecht, Renato; Fejtova, Anna; Saied, Essa M.; Arenz, Christoph; Bozec, Aline; Wank, Isabel; Kreitz, Silke; Hess, Andreas; Bäuerle, Tobias; Ledesma, Maria Dolores; Mitroi, Daniel N.; Miranda, André M.; Oliveira, Tiago G.; Gulbins, Erich; Lenz, Bernd; Schumann, Gunter; Kornhuber, Johannes; Müller, Christian P.

Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects

In: Molecular Psychiatry Vol. 26 (2021) Nr. 12, pp. 7403 - 7416

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Multiple Hepatic and Pulmonary Tumors Combined with Bilateral Adrenal Masses in a Young Woman with von Hippel–Lindau Disease

In: Gastroenterology Vol. 161 (2021) Nr. 4, pp. e1 - e4

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Zhang, Xiang; Schuhmachers, Patrick; Mourão, André; Giansanti, Piero; Murer, Anita; Thumann, Sybille; Kuklik-Roos, Cornelia; Beer, Sophie; Hauck, Stefanie M; Hammerschmidt, Wolfgang; Küppers, Ralf; Kuster, Bernhard; Raab, Monika; Strebhardt, Klaus; Sattler, Michael; Münz, Christian; Kempkes, Bettina

PLK1-dependent phosphorylation restrains EBNA2 activity and lymphomagenesis in EBV-infected mice

In: EMBO Reports (2021) e53007

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Quambusch, Lena; Depta, Laura; Landel, Ina; Lubeck, Melissa; Kirschner, Tonia; Nabert, Jonas; Uhlenbrock, Niklas; Weisner, Jörn; Kostka, Michael; Levy, Laura M.; Schultz-Fademrecht, Carsten; Glanemann, Franziska; Althoff, Kristina; Müller, Matthias P.; Siveke, Jens; Rauh, Daniel

Cellular model system to dissect the isoform-selectivity of Akt inhibitors

In: Nature Communications Vol. 12 (2021) Nr. 1, 5297

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Brägelmann, Johannes; Lorenz, Carina; Borchmann, Sven; Nishii, Kazuya; Wegner, Julia; Meder, Lydia; Ostendorp, Jenny; Ast, David F.; Heimsoeth, Alena; Nakasuka, Takamasa; Hirabae, Atsuko; Okawa, Sachi; Dammert, Marcel A.; Plenker, Dennis; Klein, Sebastian; Lohneis, Philipp; Gu, Jianing; Godfrey, Laura K.; Forster, Jan; Trajkovic-Arsic, Marija; Zillinger, Thomas; Haarmann, Mareike; Quaas, Alexander; Lennartz, Stefanie; Schmiel, Marcel; D’Rozario, Joshua; Thomas, Emily S.; Li, Henry; Schmitt, Clemens A.; George, Julie; Thomas, Roman K.; von Karstedt, Silvia; Hartmann, Gunther; Büttner, Reinhard; Ullrich, Roland T.; Siveke, Jens; Ohashi, Kadoaki; Schlee, Martin; Sos, Martin L.

MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I

In: Nature Communications Vol. 12 (2021) Nr. 1, 5505

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Hope, Thomas A.; Eiber, Matthias; Armstrong, Wesley R.; Juarez, Roxanna; Murthy, Vishnu; Lawhn-Heath, Courtney; Behr, Spencer C.; Zhang, Li; Barbato, Francesco; Ceci, Francesco; Farolfi, Andrea; Schwarzenböck, Sarah M.; Unterrainer, Marcus; Zacho, Helle D.; Nguyen, Hao G.; Cooperberg, Matthew R.; Carroll, Peter R.; Reiter, Robert E.; Holden, Stuart; Herrmann, Ken; Zhu, Shaojun; Fendler, Wolfgang; Czernin, Johannes; Calais, Jeremie

Diagnostic Accuracy of ⁶⁸Ga-PSMA-11 PET for Pelvic Nodal Metastasis Detection Prior to Radical Prostatectomy and Pelvic Lymph Node Dissection : A Multicenter Prospective Phase 3 Imaging Trial

In: JAMA Oncology Vol. 7 (2021) Nr. 11, pp. 1635 - 1642

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TRIP6 functions in brain ciliogenesis

In: Nature Communications Vol. 12 (2021) Nr. 1, 5887

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Littwitz-Salomon, Elisabeth; Moreira, Diana; Frost, Joe N.; Choi, Chloe; Liou, Kevin T.; Ahern, David K.; O’Shaughnessy, Simon; Wagner, Bernd; Biron, Christine A.; Drakesmith, Hal; Dittmer, Ulf; Finlay, David K.

Metabolic requirements of NK cells during the acute response against retroviral infection

In: Nature Communications Vol. 12 (2021) Nr. 1, 5376

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Hoertel, Nicolas; Sánchez-Rico, Marina; Cougoule, Céline; Gulbins, Erich; Kornhuber, Johannes; Carpinteiro, Alexander; Becker, Katrin Anne; Reiersen, Angela M.; Lenze, Eric J.; Seftel, David; Lemogne, Cédric; Limosin, Frédéric

Repurposing antidepressants inhibiting the sphingomyelinase acid/ceramide system against COVID-19 : Current evidence and potential mechanisms

In: Molecular Psychiatry Vol. 26 (2021) Nr. 12, pp. 7098 - 7099

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Scaled preparation of extracellular vesicles from conditioned media

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NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence

In: Nature Communications Vol. 12 (2021) Nr. 1, 4700

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Gafita, Andrei; Calais, Jeremie; Grogan, Tristan R.; Hadaschik, Boris; Wang, Hui; Weber, Manuel; Sandhu, Shahneen; Kratochwil, Clemens; Esfandiari, Rouzbeh; Tauber, Robert; Zeldin, Anna; Rathke, Hendrik; Armstrong, Wesley R.; Robertson, Andrew; Thin, Pan; D'Alessandria, Calogero; Rettig, Matthew B.; Delpassand, Ebrahim S.; Haberkorn, Uwe; Elashoff, David; Herrmann, Ken; Czernin, Johannes; Hofman, Michael S.; Fendler, Wolfgang; Eiber, Matthias

Nomograms to predict outcomes after ¹⁷⁷Lu-PSMA therapy in men with metastatic castration-resistant prostate cancer : An international, multicentre, retrospective study

In: The Lancet Oncology Vol. 22 (2021) Nr. 8, pp. 1115 - 1125

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Adamczyk, Alexandra; Pastille, Eva; Kehrmann, Jan; Vu, Vivian P.; Geffers, Robert; Wasmer, Marie-Hélène; Kasper, Stefan; Schuler, Martin; Lange, Christian; Muggli, Beat; Rau, Tilman T.; Klein, Diana; Hansen, Wiebke; Krebs, Philippe; Buer, Jan; Westendorf, Astrid

GPR15 facilitates recruitment of regulatory T cells to promote colorectal cancer

In: Cancer Research Vol. 81 (2021) Nr. 11, pp. 2970 - 2982

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de Semir, David; Bezrookove, Vladimir; Nosrati, Mehdi; Dar, Altaf A.; Miller, James R.; Leong, Stanley P.; Kim, Kevin B.; Liao, Wilson; Soroceanu, Liliana; McAllister, Sean; Debs, Robert J.; Schadendorf, Dirk; Leachman, Sancy A.; Cleaver, James E.; Kashani-Sabet, Mohammed

Nuclear receptor coactivator NCOA3 regulates UV radiation⇓induced DNA damage and melanoma susceptibility

In: Cancer Research Vol. 81 (2021) Nr. 11, pp. 2956 - 2969

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Bottomley, Andrew; Coens, Corneel; Mierzynska, Justyna; Blank, Christian U; Mandalà, Mario; Long, Georgina V; Atkinson, Victoria G; Dalle, Stéphane; Haydon, Andrew M; Meshcheryakov, Andrey; Khattak, Adnan; Carlino, Matteo S; Sandhu, Shahneen; Puig, Susana; Ascierto, Paolo A; Larkin, James; Lorigan, Paul C; Rutkowski, Piotr; Schadendorf, Dirk; Koornstra, Rutger; Hernandez-Aya, Leonel; Di Giacomo, Anna Maria; van den Eertwegh, Alfonsus J M; Grob, Jean-Jacques; Gutzmer, Ralf; Jamal, Rahima; van Akkooi, Alexander C J; Krepler, Clemens; Ibrahim, Nageatte; Marreaud, Sandrine; Kicinski, Michal; Suciu, Stefan; Robert, Caroline; Eggermont, Alexander M M; Lesimple, Thierry; Maio, Michele; Linette, Gerald; Mortier, Laurent; Svane, Inge Marie; Schachter, Jacob; Brown, Michael; Hersey, Peter; Barrow, Catherine; Kudchadkar, Ragini; Dutriaux, Caroline; Song, Xinni; Quaglino, Pietro; Queirolo, Paola; Meier, Friedegund; Stroyakovskiy, Daniil; Guillot, Bernard; Romero, Pablo Luis Ortiz; Bastholt, Lars; Garbe, Claus; Grange, Florent; Mohr, Peter; Algazi, Alain; Bechter, Oliver; Hernberg, Micaela; Loquai, Carmen; Meiss, Frank; Chiarion Sileni, Vanna; Bar-Sela, Gil; Fitzharris, Bernard; Saiag, Philippe; Arnault, Jean-Philippe; Simon, Jan-Christoph; Stephens, Rosalie; Baurain, Jean-Francois; Lebbe, Célèste; Combemale, Patrick; Dummer, Reinhard; Hauschild, Axel; Parente, Phillip; Yamazaki, Naoya; Milhem, Mohammed; Leccia, Marie-Thérèse; Geoffrois, Lionel; Kretschmer, Lutz; Dunwoodie, Elaine; Walker, John; Lotem, Michal; Hendler, Daniel; Mackiewicz, Andrzej; Sekulovic, Lidija; Dzienis, Marcin; Hospers, Geke A.P.; Siano, Marco; Hassel, Jessica; Corrie, Philippa; Passos, Maria-Jose; Levin, Max; Hoeller, Christoph; Machet, Laurent; Hallmeyer, Sigrun; Waterston, Ashita; Descamps, Vincent; Kiecker, Felix; Aarts, Maureen; Schmidt, Henrik; Raimundo, Ana; Nyakas, Marta; Lacour, Jean-Philippe; Berking, Carola; Ferrucci, Pier Francesco; Jameson, Michael; Kim, Kevin; Yokota, Kenji; Kerger, Joseph; Aubin, François; Groenewegen, Gerard; Kapiteijn, Helena; Boehncke, Wolf-Henning; Utikal, Jochen; Casasola, Richard; Marshall, Ernest; Ferraresi, Virginia; Richtig, Erika; Matkovic, Suzana; Inozume, Takashi; Crook, Timothy; McNeil, Catriona; Kiyohara, Yoshio; Avril, Marie-Francoise; Hein, Rüdiger; Terheyden, Patrick; Nathan, Paul; Aoi, Jun; Skytta, Tanja; Jouary, Thomas; Takenouchi, Tatsuya; Straume, Oddbjorn; Martins, César; Mukhametshina, Guzel

Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054) : health-related quality-of-life results from a double-blind, randomised, controlled, phase 3 trial

In: The Lancet Oncology Vol. 22 (2021) Nr. 5, pp. 655 - 664

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Wick, Antje; Bahr, Oliver; Schuler, Martin; Rohrberg, Kristoffer; Chawla, Sant P.; Janku, Filip; Schiff, David; Heinemann, Volker; Narita, Yoshitaka; Lenz, Heinz-Josef; Ikeda, Masafumi; Ando, Yuichi; Wick, Wolfgang; Steinbach, Joachim P.; Burger, Michael C.; Wenger, Katharina; Lassen, Ulrik; Sankhala, Kamalesh K.; Roggia, Cristiana; Genvresse, Isabelle; Munhoz, Catya; Rentzsch, Christine; Reschke, Susanne; Langer, Simon; Wagner, Markus; Kaulfuss, Stefan; Cai, Charles; Lagkadinou, Eleni; Jeffers, Michael; Peña, Carol; Tabatabai, Ghazaleh

Phase I assessment of safety and therapeutic activity of BAY1436032 in patients with IDH1-mutant solid tumors

In: Clinical Cancer Research Vol. 27 (2021) Nr. 10, pp. 2723 - 2733

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Eggermont, Alexander M M; Blank, Christian U; Mandalà, Mario; Long, Georgina V; Atkinson, Victoria G; Dalle, Stéphane; Haydon, Andrew M; Meshcheryakov, Andrey; Khattak, Adnan; Carlino, Matteo S; Sandhu, Shahneen; Larkin, James; Puig, Susana; Ascierto, Paolo A; Rutkowski, Piotr; Schadendorf, Dirk; Koornstra, Rutger; Hernandez-Aya, Leonel; Di Giacomo, Anna Maria; van den Eertwegh, Alfonsus J M; Grob, Jean-Jacques; Gutzmer, Ralf; Jamal, Rahima; Lorigan, Paul C; van Akkooi, Alexander C J; Krepler, Clemens; Ibrahim, Nageatte; Marreaud, Sandrine; Kicinski, Michal; Suciu, Stefan; Robert, Caroline; Menzies, Alex; Lesimple, Thierry; Maio, Michele; Linette, Gerald; Brown, Michael; Hersey, Peter; Svane, Inge Marie; Mortier, Laurent; Schachter, Jacob; Barrow, Catherine; Kudchadkar, Ragini; Song, Xinni; Dutriaux, Caroline; Quaglino, Pietro; Meier, Friedegund; Queirolo, Paola; Stroyakovskiy, Daniil; Bastholt, Lars; Guillot, Bernard; Garbe, Claus; Ortiz Romero, Pablo Luis; Grange, Florent; Mohr, Peter; Algazi, Alain; Bechter, Oliver; Hernberg, Micaela; Arnault, Jean-Philippe; Saiag, Philippe; Loquai, Carmen; Meiss, Frank; Simon, Jan-Christoph; Bar-Sela, Gil; Chiarion Sileni, Vanna; Fitzharris, Bernard; McCrystal, Mike; Parente, Phillip; Baurain, Jean-Francois; Combemale, Patrick; Lebbe, Célèste; Hauschild, Axel; Yamazaki, Naoya; Dummer, Reinhard; Milhem, Mohammed; Dzienis, Marcin; Walker, John; Geoffrois, Lionel; Leccia, Marie-Thérèse; Kretschmer, Lutz; Hendler, Daniel; Lotem, Michal; Mackiewicz, Andrzej; Sekulovic, Lidija; Dunwoodie, Elaine; Hoeller, Christoph; Machet, Laurent; Hassel, Jessica; Hospers, Geke A.P.; Passos, Maria-Jose; Levin, Max; Fehr, Martin; Corrie, Philippa; Waterston, Ashita; Hallmeyer, Sigrun; Schmidt, Henrik; Descamps, Vincent; Lacour, Jean-Philippe; Berking, Carola; Kiecker, Felix; Ferrucci, Pier Francesco; Yokota, Kenji; Aarts, Maureen; Jameson, Michael; Winge-Main, Anna Katharina; Ferreira, Paula; Kim, Kevin; McNeil, Catriona; Hofmann-Wellenhof, Reiner; Kerger, Joseph; Aubin, François; Utikal, Jochen; Ferraresi, Virginia; Inozume, Takashi; Kiyohara, Yoshio; Groenewegen, Gerard; Kapiteijn, Helena; Matkovic, Suzana; Boehncke, Wolf-Henning; Casasola, Richard; Crook, Timothy; Marshall, Ernest; Skytta, Tanja; Avril, Marie-Francoise; Jouary, Thomas; Hein, Rüdiger; Terheyden, Patrick; Aoi, Jun; Takenouchi, Tatsuya; Straume, Oddbjorn; Martins, César; Mukhametshina, Guzel; Nathan, Paul

Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054) : distant metastasis-free survival results from a double-blind, randomised, controlled, phase 3 trial

In: The Lancet Oncology Vol. 22 (2021) Nr. 5, pp. 643 - 654

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Syeda, Mahrukh M.; Wiggins, Jennifer M.; Corless, Broderick C; Long, Georgina V.; Flaherty, Keith T.; Schadendorf, Dirk; Nathan, Paul D.; Robert, Caroline; Ribas, Antoni; Davies, Michael A.; Grob, Jean Jacques; Gasal, Eduard; Squires, Matthew; Marker, Mahtab; Garrett, James; Brase, Jan C.; Polsky, David

Circulating tumour DNA in patients with advanced melanoma treated with dabrafenib or dabrafenib plus trametinib : A clinical validation study

In: The Lancet Oncology Vol. 22 (2021) Nr. 3, pp. 370 - 380

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Schuler, Martin

Corrigendum to “Inhibiting fibroblast growth factor receptors in cancer – The next generation”

In: Annals of Oncology Vol. 32 (2021) Nr. 1, pp. 126

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Rassaf, Tienush; Heusch, Gerd

The West German heart and vascular center at university medicine Essen

In: European Heart Journal Vol. 42 (2021) Nr. 10, pp. 963 - 964

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Iliakis, George E.

New players in the regulation of DNA-PK activity : Survivin joins the crowd

In: Cancer Research Vol. 81 (2021) Nr. 9, pp. 2270 - 2271

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Rankin-Turner, Stephanie; Vader, Pieter; O'Driscoll, Lorraine; Giebel, Bernd; Heaney, Liam M.; Davies, Owen G.

A call for the standardised reporting of factors affecting the exogenous loading of extracellular vesicles with therapeutic cargos

In: Advanced Drug Delivery Reviews Vol. 173 (2021) pp. 479 - 491

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Hübschmann, Daniel; Kleinheinz, Kortine; Wagener, Rabea; Bernhart, Stephan H.; López, Cristina; Toprak, Umut H.; Sungalee, Stephanie; Ishaque, Naveed; Kretzmer, Helene; Kreuz, Markus; Waszak, Sebastian M.; Paramasivam, Nagarajan; Ammerpohl, Ole; Aukema, Sietse M.; Beekman, Renée; Bergmann, Anke K.; Bieg, Matthias; Binder, Hans; Borkhardt, Arndt; Borst, Christoph; Brors, Benedikt; Bruns, Philipp; Carrillo de Santa Pau, Enrique; Claviez, Alexander; Doose, Gero; Haake, Andrea; Karsch, Dennis; Haas, Siegfried; Hansmann, Martin-Leo; Hoell, Jessica I.; Hovestadt, Volker; Huang, Bingding; Hummel, Michael; Jäger-Schmidt, Christina; Kerssemakers, Jules N. A.; Korbel, Jan O.; Kube, Dieter; Lawerenz, Chris; Lenze, Dido; Martens, Joost H. A.; Ott, German; Radlwimmer, Bernhard; Reisinger, Eva; Richter, Julia; Rico, Daniel; Rosenstiel, Philip; Rosenwald, Andreas; Schillhabel, Markus; Stilgenbauer, Stephan; Stadler, Peter F.; Martín-Subero, José I.; Szczepanowski, Monika; Warsow, Gregor; Weniger, Marc; Zapatka, Marc; Valencia, Alfonso; Stunnenberg, Hendrik G.; Lichter, Peter; Möller, Peter; Loeffler, Markus; Eils, Roland; Klapper, Wolfram; Hoffmann, Steve; Trümper, Lorenz; Küppers, Ralf; Schlesner, Matthias; Siebert, Reiner

Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas

In: Leukemia Vol. 35 (2021) pp. 2002 - 2016

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van Sorge, Nina M.; Bonsor, Daniel A.; Deng, Liwen; Lindahl, Erik; Schmitt, Verena; Lyndin, Mykola; Schmidt, Alexej; Nilsson, Olof R.; Brizuela, Jaime; Boero, Elena; Sundberg, Eric J.; van Strijp, Jos A. G.; Doran, Kelly S.; Singer, Bernhard B.; Lindahl, Gunnar; McCarthy, Alex J.

Bacterial protein domains with a novel Ig-like fold target human CEACAM receptors

In: The EMBO Journal Vol. 40 (2021) Nr. 7, pp. e106103

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Klein, Sebastian; Quaas, Alexander; Quantius, Jennifer; Löser, Heike; Meinel, Jörn; Peifer, Martin; Wagner, Steffen; Gattenlöhner, Stefan; Wittekindt, Claus; von Knebel Doeberitz, Magnus; Prigge, Elena-Sophie; Langer, Christine; Noh, Ka-Won; Maltseva, Margaret; Reinhardt, Hans Christian; Büttner, Reinhard; Klussmann, Jens Peter; Wuerdemann, Nora

Deep Learning Predicts HPV Association in Oropharyngeal Squamous Cell Carcinomas and Identifies Patients with a Favorable Prognosis Using Regular H&E Stains

In: Clinical Cancer Research Vol. 27 (2021) Nr. 4, pp. 1131 - 1138

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Henneberg, Sophie; Hasenberg, Anja; Maurer, Andreas; Neumann, Franziska; Bornemann, Lea; Gonzalez-Menendez, Irene; Kraus, Andreas; Hasenberg, Mike; Thornton, Christopher R.; Pichler, Bernd J.; Gunzer, Matthias; Beziere, Nicolas

Antibody-guided in vivo imaging of Aspergillus fumigatus lung infections during antifungal azole treatment

In: Nature Communications Vol. 12 (2021) Nr. 1, pp. 1707

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Chuang, Chen-Hua; Dorsch, Madeleine; Dujardin, Philip; Silas, Sukrit; Ueffing, Kristina; Hölken, Johanna M; Yang, Dian; Winslow, Monte M.; Grüner, Barbara M.

Altered mitochondria functionality defines a metastatic cell state in lung cancer and creates an exploitable vulnerability

In: Cancer Research Vol. 81 (2021) Nr. 3, pp. 567 - 579

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Şahin, Uǧur; Türeci, Özlem; Manikhas, Georgiy Moiseevich; Lordick, Florian; Rusyn, Andrii; Vynnychenko, Ihor A.; Dudov, Asen; Bazin, Igor S.; Bondarenko, Igor; Melichar, Bohuslav; Dhaene, Karl F.L.; Wiechen, Kai; Huber, Claudia; Maurus, Daniel; Arozullah, A.; Park, J.W.; Schuler, Martin; Al-Batran, Salah Eddin

FAST : a randomised phase II study of zolbetuximab (IMAB362) plus EOX versus EOX alone for first-line treatment of advanced CLDN18.2-positive gastric and gastro-oesophageal adenocarcinoma

In: Annals of Oncology Vol. 32 (2021) Nr. 5, pp. 609 - 619

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Herrmann, Ken; Kraus, Bernd Joachim; Hadaschik, Boris; Kunikowska, Jolanta; van Poppel, Hendrik; N'Dow, James; Sartor, Oliver; Oyen, Wim J. G.

Nuclear medicine theranostics comes of age

In: The Lancet Oncology Vol. 22 (2021) Nr. 11, pp. 1497 - 1498

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Heming, Michael; Li, Xiaolin; Räuber, Saskia; Mausberg, Anne K.; Börsch, Anna-Lena; Hartlehnert, Maike; Singhal, Arpita; Lu, I-Na; Fleischer, Michael; Szepanowski, Fabian; Witzke, Oliver; Brenner, Thorsten; Dittmer, Ulf; Yosef, Nir; Kleinschnitz, Christoph; Wiendl, Heinz; Stettner, Mark; Meyer zu Hörste, Gerd

Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid

In: Immunity Vol. 54 (2021) Nr. 1, pp. 164

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Cappello, Sabrina; Sung, Hsu-Min; Ickes, Christian; Gibhardt, Christine S.; Vultur, Adina; Bhat, Hilal; Hu, Zhongwen; Brafford, Patricia; Denger, Andreas; Stejerean-Todoran, Ioana; Köhn, Rixa-Mareike; Lorenz, Verena; Künzel, Nicolas; Salinas, Gabriela; Stanisz, Hedwig; Legler, Tobias; Rehling, Peter; Schön, Michael P.; Lang, Karl S.; Helms, Volkhard; Herlyn, Meenhard; Hoth, Markus; Kummerow, Carsten; Bogeski, Ivan

Protein Signatures of NK Cell–Mediated Melanoma Killing Predict Response to Immunotherapies

In: Cancer Research Vol. 81 (2021) Nr. 21, pp. 5540 - 5554

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Küppers, Ralf

Sugar-modified B-cell receptors in DLBCL

In: Blood Vol. 138 (2021) Nr. 17, pp. 1512 - 1514

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Anquetil, Typhaine; Solinhac, Romain; Jaffre, Aude; Chicanne, Gaëtan; Viaud, Julien; Darcourt, Jean; Orset, Cyrille; Geuss, Eva; Kleinschnitz, Christoph; Vanhaesebroeck, Bart; Vivien, Denis; Hnia, Karim; Larrue, Vincent; Payrastre, Bernard; Gratacap, Marie‐Pierre

PI3KC2β inactivation stabilizes VE‐cadherin junctions and preserves vascular integrity

In: EMBO Reports (2021) pp. e51299

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Kunzmann, Volker; Siveke, Jens; Algül, Hana; Goekkurt, Eray; Siegler, Gabriele; Martens, Uwe; Waldschmidt, Dirk; Pelzer, Uwe; Fuchs, Martin; Kullmann, Frank; Boeck, Stefan; Ettrich, Thomas J; Held, Swantje; Keller, Ralph; Klein, Ingo; Germer, Christoph-Thomas; Stein, Hubert; Friess, Helmut; Bahra, Marcus; Jakobs, Ralf; Hartlapp, Ingo; Heinemann, Volker; German Pancreatic Cancer Working Group (AIO-PAK) and NEOLAP investigators; Stahl, Michael; Mahlmann, Stefan

Nab-paclitaxel plus gemcitabine versus nab-paclitaxel plus gemcitabine followed by FOLFIRINOX induction chemotherapy in locally advanced pancreatic cancer (NEOLAP-AIO-PAK-0113) : a multicentre, randomised, phase 2 trial

In: The Lancet Gastroenterology & Hepatology Vol. 6 (2021) Nr. 2, pp. 128 - 138

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Gronchi, A.; Miah, A.B.; Dei Tos, A.P.; Abecassis, N.; Bajpai, J.; Bauer, Sebastian; Biagini, R.; Bielack, S.; Blay, J.Y.; Bolle, S.; Bonvalot, S.; Boukovinas, I.; Bovee, J.V.M.G.; Boye, K.; Brennan, B.; Brodowicz, T.; Buonadonna, A.; De Álava, E.; Del Muro, X.G.; Dufresne, A.; Eriksson, M.; Fagioli, F.; Fedenko, A.; Ferraresi, V.; Ferrari, A.; Frezza, A.M.; Gasperoni, S.; Gelderblom, H.; Gouin, F.; Grignani, G.; Haas, R.; Hassan, A.B.; Hecker-Nolting, S.; Hindi, N.; Hohenberger, P.; Joensuu, H.; Jones, R.L.; Jungels, C.; Jutte, P.; Kager, L.; Kasper, B.; Kawai, A.; Kopeckova, K.; Krákorová, D.A.; Le Cesne, A.; Le Grange, F.; Legius, E.; Leithner, A.; Lopez-Pousa, A.; Martin-Broto, J.; Merimsky, O.; Messiou, C.; Mir, O.; Montemurro, M.; Morland, B.; Morosi, C.; Palmerini, E.; Pantaleo, M.A.; Piana, R.; Piperno-Neumann, S.; Reichardt, P.; Rutkowski, P.; Safwat, A.A.; Sangalli, C.; Sbaraglia, M.; Scheipl, S.; Schöffski, P.; Sleijfer, S.; Strauss, D.; Strauss, S.; Sundby Hall, K.; Trama, A.; Unk, M.; van de Sande, M.A.J.; van der Graaf, W.T.A.; van Houdt, W.J.; Frebourg, T.; Casali, P.G.; Stacchiotti, S.

Soft tissue and visceral sarcomas : ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up☆

In: Annals of Oncology Vol. 32 (2021) Nr. 11, 1348-1365

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Weniger, Marc; Küppers, Ralf

Molecular biology of Hodgkin lymphoma

In: Leukemia Vol. 35 (2021) Nr. 4, pp. 968 - 981

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Meurer, Thuja; Crivello, Pietro; Metzing, Maximilian Frederik; Kester, Michel; Megger, Dominik A.; Chen, Weiqiang; van Veelen, PA; van Balen, Peter; Westendorf, Astrid; Homa, Georg; Layer, Sophia E.; Turki, Amin T.; Griffioen, Marieke; Horn, Peter; Sitek, Barbara; Beelen, Dietrich; Falkenburg, J.H.Frederik; Arrieta-Bolaños, Esteban; Fleischhauer, Katharina

Permissive HLA-DPB1 mismatches in HCT depend on immunopeptidome divergence and editing by HLA-DM

In: Blood Vol. 137 (2021) Nr. 7, pp. 923 - 928

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Subbiah, Vivek; Hu, Mimi I.; Wirth, Lori J.; Schuler, Martin; Mansfield, Aaron S.; Curigliano, Giuseppe; Brose, Marcia S.; Zhu, Viola W.; Leboulleux, Sophie; Bowles, Daniel W.; Baik, Christina S.; Adkins, Douglas; Keam, Bhumsuk; Matos, Ignacio; Garralda, Elena; Gainor, Justin F.; Lopes, Gilberto; Lin, Chia-Chi; Godbert, Yann; Sarker, Debashis; Miller, Stephen G.; Clifford, Corinne; Zhang, Hui; Turner, Christopher D.; Taylor, Matthew H.

Pralsetinib for patients with advanced or metastatic RET-altered thyroid cancer (ARROW) : a multi-cohort, open-label, registrational, phase 1/2 study

In: The Lancet Diabetes and Endocrinology Vol. 9 (2021) Nr. 8, pp. 491 - 501

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Brase, Jan C.; Walter, Robert F.H.; Savchenko, Alexander; Gusenleitner, Daniel; Garrett, James; Schimming, Tobias; Varaljai, Renata; Castelletti, Deborah; Kim, Ju; Dakappagari, Naveen; Schultz, Ken; Robert, Caroline; Long, Georgina V.; Nathan, Paul D.; Ribas, Antoni; Flaherty, Keith T.; Karaszewska, Boguslawa; Schachter, Jacob; Sucker, Antje; Schmid, Kurt Werner; Zimmer, Lisa; Livingstone, Elisabeth; Gasal, Eduard; Schadendorf, Dirk; Rösch, Alexander

Role of Tumor-Infiltrating B Cells in Clinical Outcome of Patients with Melanoma Treated With Dabrafenib Plus Trametinib

In: Clinical Cancer Research Vol. 27 (2021) Nr. 16, pp. 4500 - 4510

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Skoulidis, Ferdinandos; Li, Bob T.; Dy, Grace K.; Price, Timothy J.; Falchook, Gerald S.; Wolf, Jürgen; Italiano, Antoine; Schuler, Martin; Borghaei, Hossein; Barlesi, Fabrice; Kato, Terufumi; Curioni-Fontecedro, Alessandra; Sacher, Adrian; Spira, Alexander; Ramalingam, Suresh S.; Takahashi, Toshiaki; Besse, Benjamin; Anderson, Abraham; Ang, Agnes; Tran, Qui; Mather, Omar; Henary, Haby; Ngarmchamnanrith, Gataree; Friberg, Gregory; Velcheti, Vamsidhar; Govindan, Ramaswamy

Sotorasib for Lung Cancers with KRAS p.G12C Mutation

In: The New England Journal of Medicine Vol. 384 (2021) Nr. 25, pp. 2371 - 2381

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Bebber, Christina M.; Thomas, Emily S.; Stroh, Jenny; Chen, Zhiyi; Androulidaki, Ariadne; Schmitt, Anna; Höhne, Michaela N.; Stüker, Lukas; de Pádua Alves, Cleidson; Khonsari, Armin; Dammert, Marcel A.; Parmaksiz, Fatma; Tumbrink, Hannah L.; Beleggia, Filippo; Sos, Martin L.; Riemer, Jan; George, Julie; Brodesser, Susanne; Thomas, Roman K.; Reinhardt, Christian; von Karstedt, Silvia

Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes

In: Nature Communications Vol. 12 (2021) Nr. 1, pp. 2048

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Veach, Darren R.; Storey, Claire M.; Lückerath, Katharina; Braun, Katharina; von Bodman, Christian; Lamminmäki, Urpo; Kalidindi, Teja; Strand, Sven-Erik; Strand, Joanna; Altai, Mohamed; Damoiseaux, Robert; Zanzonico, Pat; Benabdallah, Nadia; Pankov, Dmitry; Scher, Howard I.; Scardino, Peter; Larson, Steven M.; Lilja, Hans; McDevitt, Michael R.; Thorek, Daniel L.J.; Ulmert, David

PSA-Targeted Alpha-, Beta-, and Positron-Emitting Immunotheranostics in Murine Prostate Cancer Models and Nonhuman Primates

In: Clinical Cancer Research Vol. 27 (2021) Nr. 7, pp. 2050 - 2060

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Grunewald, Susanne; Klug, Lillian R.; Mühlenberg, Thomas; Lategahn, Jonas; Falkenhorst, Johanna; Town, Ajia; Ehrt, Christiane; Wardelmann, Eva; Hartmann, Wolfgang; Schildhaus, Hans-Ulrich; Treckmann, Jürgen-Walter; Fletcher, Jonathan A.; Jung, Sascha; Czodrowski, Paul; Miller, Stephen; Schmidt-Kittler, Oleg; Rauh, Daniel; Heinrich, Michael C.; Bauer, Sebastian

Resistance to avapritinib in pdgfra-driven gist is caused by secondary mutations in the pdgfra kinase domain

In: Cancer Discovery Vol. 11 (2021) Nr. 1, pp. 108 - 125

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Wu, Jun; Liang, Boyun; Chen, Cunrong; Wang, Hua; Fang, Yaohui; Shen, Shu; Yang, Xiaoli; Wang, Baoju; Chen, Liangkai; Chen, Qi; Wu, Yang; Liu, Jia; Yang, Xuecheng; Li, Wei; Zhu, Bin; Zhou, Wenqing; Wang, Huan; Li, Sumeng; Lu, Sihong; Liu, Di; Li, Huadong; Krawczyk, Adalbert; Lu, Mengji; Yang, Dongliang; Deng, Fei; Dittmer, Ulf; Trilling, Mirko; Zheng, Xin

SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19

In: Nature Communications Vol. 12 (2021) Nr. 1, pp. 1813

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Tumor-associated hematopoietic stem and progenitor cells positively linked to glioblastoma progression

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Functional Comparison of Interferon-α Subtypes Reveals Potent Hepatitis B Virus Suppression by a Concerted Action of Interferon-α and Interferon-γ Signaling

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Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache : A multicentre, double-blind, randomised controlled trial

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Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy

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Post-transplantation cyclophosphamide GvHD prophylaxis after hematopoietic stem cell transplantation from 9/10 or 10/10 HLA-matched unrelated donors for acute leukemia

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Association of BRAF V600E/K Mutation Status and Prior BRAF/MEK Inhibition with Pembrolizumab Outcomes in Advanced Melanoma : Pooled Analysis of 3 Clinical Trials

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Author Correction: Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma

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Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

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Author Correction: Tertiary lymphoid structures improve immunotherapy and survival in melanoma

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Avapritinib in advanced PDGFRA D842V-mutant gastrointestinal stromal tumour (NAVIGATOR) : A multicentre, open-label, phase 1 trial

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Co-option of Neutrophil Fates by Tissue Environments

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Combined PD-1, BRAF and MEK inhibition in advanced BRAF-mutant melanoma : safety run-in and biomarker cohorts of COMBI-i

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Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypes

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A clinical perspective on the 2019 ESC/EAS guidelines for the management of dyslipidaemias: PCSK-9 inhibitors for all?

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Five-Year Analysis of Adjuvant Dabrafenib plus Trametinib in Stage III Melanoma

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Genomic footprints of activated telomere maintenance mechanisms in cancer

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Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours

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Durable and controlled depletion of neutrophils in mice

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Heterobifunctional Rotaxanes for Asymmetric Catalysis

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High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations

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A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

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Anemia increases long-term mortality in patients undergoing conventional coronary angiography – the ECAT registry
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Combined burden and functional impact tests for cancer driver discovery using DriverPower

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Hypoxia Induces Resistance to EGFR Inhibitors in Lung Cancer Cells via Upregulation of FGFR1 and the MAPK Pathway

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External validation of models for KIR2DS1/KIR3DL1-informed selection of hematopoietic cell donors fails

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Inferring structural variant cancer cell fraction

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Divergent mutational processes distinguish hypoxic and normoxic tumours

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Integrative Analysis of Pleomorphic Dermal Sarcomas Reveals Fibroblastic Differentiation and Susceptibility to Immunotherapy

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Integrative pathway enrichment analysis of multivariate omics data

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Integrated molecular drivers coordinate biological and clinical states in melanoma

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Survival Outcomes Associated with 3 Years vs 1 Year of Adjuvant Imatinib for Patients with High-Risk Gastrointestinal Stromal Tumors : An Analysis of a Randomized Clinical Trial after 10-Year Follow-up

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Investigating PSMA-Targeted Radioligand Therapy Efficacy as a Function of Cellular PSMA Levels and Intratumoral PSMA Heterogeneity

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Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations

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Radiotheranostics : A roadmap for future development

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Nusinersen in adults with 5q spinal muscular atrophy : A non-interventional, multicentre, observational cohort study

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Pathway and network analysis of more than 2500 whole cancer genomes

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Non-classical monocyte homing to the gut via α4β7 integrin mediates macrophage-dependent intestinal wound healing

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Safety and efficacy of GABAA α5 antagonist S44819 in patients with ischaemic stroke : A multicentre, double-blind, randomised, placebo-controlled trial

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Rationale for Immune Checkpoint Inhibitors plus Targeted Therapy in Metastatic Melanoma : A Review

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Prognostic impact of baseline tumour immune infiltrate on disease-free survival in patients with completely resected, BRAFv⁶⁰⁰ mutation–positive melanoma receiving adjuvant vemurafenib

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Association between Immune-Related Adverse Events and Recurrence-Free Survival among Patients with Stage III Melanoma Randomized to Receive Pembrolizumab or Placebo : A Secondary Analysis of a Randomized Clinical Trial

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Molecular profiling of neuroendocrine tumours to predict response and toxicity to peptide receptor radionuclide therapy

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Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility

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Adjuvant nivolumab plus ipilimumab or nivolumab monotherapy versus placebo in patients with resected stage IV melanoma with no evidence of disease (IMMUNED) : A randomised, double-blind, placebo-controlled, phase 2 trial

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Cemiplimab in locally advanced cutaneous squamous cell carcinoma : results from an open-label, phase 2, single-arm trial

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Immunotherapeutic blockade of CD47 inhibitory signaling enhances innate and adaptive immune responses to viral infection

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Molecular correlates of response to capmatinib in advanced non-small-cell lung cancer : Clinical and biomarker results from a phase I trial

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Elevated baseline serum PD-1 or PD-L1 predicts poor outcome of PD-1 inhibition therapy in metastatic melanoma

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Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease

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Lymphocyte predominant cells detect Moraxella catarrhalis-derived antigens in nodular lymphocyte-predominant Hodgkin lymphoma

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Cardiac fibroblast activation detected by positron emission tomography/computed tomography as a possible sign of cardiotoxicity

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Crizotinib in ROS1 and MET deregulated NSCLC-letter

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Ripretinib in patients with advanced gastrointestinal stromal tumours (INVICTUS) : a double-blind, randomised, placebo-controlled, phase 3 trial

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Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury

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Safety and Efficacy of 48 Weeks REP 2139 or REP 2165, Tenofovir Disoproxil, and Pegylated Interferon Alfa-2a in Patients With Chronic HBV Infection Naïve to Nucleos(t)ide Therapy

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Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms Across Eight Psychiatric Disorders

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Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

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A multicentre, phase IIa study of zolbetuximab as a single agent in patients with recurrent or refractory advanced adenocarcinoma of the stomach or lower oesophagus : the MONO study

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López, Cristina; Kleinheinz, Kortine; Aukema, Sietse M.; Rohde, Marius; Bernhart, Stephan H.; Hübschmann, Daniel; Wagener, Rabea; Toprak, Umut H.; Raimondi, Francesco; Kreuz, Markus; Waszak, Sebastian M.; Huang, Zhiqin; Sieverling, Lina; Paramasivam, Nagarajan; Seufert, Julian; Sungalee, Stephanie; Russell, Robert B.; Bausinger, Julia; Kretzmer, Helene; Ammerpohl, Ole; Bergmann, Anke K.; Binder, Hans; Borkhardt, Arndt; Brors, Benedikt; Claviez, Alexander; Doose, Gero; Feuerbach, Lars; Haake, Andrea; Hansmann, Martin-Leo; Hoell, Jessica; Hummel, Michael; Korbel, Jan O.; Lawerenz, Chris; Lenze, Dido; Radlwimmer, Bernhard; Richter, Julia; Rosenstiel, Philip; Rosenwald, Andreas; Schilhabel, Markus B.; Stein, Harald; Stilgenbauer, Stephan; Stadler, Peter F.; Szczepanowski, Monika; Weniger, Marc; Zapatka, Marc; Eils, Roland; Lichter, Peter; Loeffler, Markus; Möller, Peter; Trümper, Lorenz; Klapper, Wolfram; Wagner, Susanne; Richter, Gesine; Eils, Jürgen; Kerssemakers, Jules; Jaeger-Schmidt, Christina; Scholz, Ingrid; Borst, Christoph; Braulke, Friederike; Dreyling, Martin; Eberth, Sonja; Einsele, Hermann; Frickhofen, Norbert; Haas, Siegfried; Karsch, Dennis; Klepl, Nicole; Kneba, Michael; Lisfeld, Jasmin; Mantovani-Löffler, Luisa; Ott, German; Stadler, Christina; Staib, Peter; Zenz, Thorsten; Kube, Dieter; Kostezka, Ulrike; Binder, Vera; Leich, Ellen; Nagel, Inga; Pischimariov, Jordan; Schreiber, Stefan; Vater, Inga; Hopp, Lydia; Langenberger, David; Rosolowski, Maciej; Hoffmann, Steve; Küppers, Ralf; Burkhardt, Birgit; Schlesner, Matthias; Siebert, Reiner

Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma

In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 1459

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Silvestre-Roig, Carlos; Braster, Quinte; Wichapong, Kanin; Lee, Ernest Y.; Teulon, Jean Marie; Berrebeh, Nihel; Winter, Janine; Adrover, José M.; Santos, Giancarlo Santiago; Froese, Alexander; Lemnitzer, Patricia; Ortega-Gómez, Almudena; Chevre, Raphael; Marschner, Julian; Schumski, Ariane; Winter, Carla; Perez-Olivares, Laura; Pan, Chang; Paulin, Nicole; Schoufour, Tom; Hartwig, Helene; González-Ramos, Silvia; Kamp, Frits; Megens, Remco T. A.; Mowen, Kerri A.; Gunzer, Matthias; Maegdefessel, Lars; Hackeng, Tilman; Lutgens, Esther; Daemen, Mat; von Blume, Julia; Anders, Hans-Joachim; Nikolaev, Viacheslav O.; Pellequer, Jean-Luc; Weber, Christian; Hidalgo, Andrés; Nicolaes, Gerry A. F.; Wong, Gerard C. L.; Soehnlein, Oliver

Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death

In: Nature Vol. 569 (2019) Nr. 7755, pp. 236 - 240

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Liu, David; Schilling, Bastian; Liu, Derek; Sucker, Antje; Livingstone, Elisabeth; Jerby-Amon, Livnat; Zimmer, Lisa; Gutzmer, Ralf; Satzger, Imke; Loquai, Carmen; Grabbe, Stephan; Vokes, Natalie; Margolis, Claire A.; Conway, Jake; He, Meng Xiao; Elmarakeby, Haitham; Dietlein, Felix; Miao, Diana; Tracy, Adam; Gogas, Helen; Goldinger, Simone M.; Utikal, Jochen; Blank, Christian U.; Rauschenberg, Ricarda; Bubnoff, Dagmar von; Krackhardt, Angela; Weide, Benjamin; Haferkamp, Sebastian; Kiecker, Felix; Izar, Ben; Garraway, Levi; Regev, Aviv; Flaherty, Keith; Paschen, Annette; Allen, Eliezer M. van; Schadendorf, Dirk

Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma

In: Nature Medicine Vol. 25 (2019) Nr. 12, pp. 1916 - 1927

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Hüllein, Jennifer; Słabicki, Mikołaj; Rosolowski, Maciej; Jethwa, Alexander; Habringer, Stefan; Tomska, Katarzyna; Kurilov, Roma; Lu, Junyan; Scheinost, Sebastian; Wagener, Rabea; Huang, Zhiqin; Lukas, Marina; Yavorska, Olena; Helfrich, Hanne; Scholtysik, René; Bonneau, Kyle; Tedesco, Donato; Küppers, Ralf; Klapper, Wolfram; Pott, Christiane; Stilgenbauer, Stephan; Burkhardt, Birgit; Löffler, Markus; Trümper, Lorenz H.; Hummel, Michael; Brors, Benedikt; Zapatka, Marc; Siebert, Reiner; Kreuz, Markus; Keller, Ulrich; Huber, Wolfgang; Zenz, Thorsten

MDM4 Is Targeted by 1q Gain and Drives Disease in Burkitt Lymphoma

In: Cancer Research Vol. 79 (2019) Nr. 12, pp. 3125 - 3138

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Karimzadeh, Hadi; Kiraithe, Muthamia M.; Oberhardt, Valerie; Salimi Alizei, Elahe; Bockmann, Jan; Schulze zur Wiesch, Julian; Budeus, Bettina; Hoffmann, Daniel; Wedemeyer, Heiner; Cornberg, Markus; Krawczyk, Adalbert; Rashidi-Alavijeh, Jassin; Rodríguez-Frías, Francisco; Casillas, Rosario; Buti, Maria; Smedile, Antonina; Alavian, Seyed Moayed; Heinold, Andreas; Emmerich, Florian; Panning, Marcus; Gostick, Emma; Price, David A.; Timm, Jörg; Hofmann, Maike; Raziorrouh, Bijan; Thimme, Robert; Protzer, Ulrike; Roggendorf, Michael; Neumann-Haefelin, Christoph

Mutations in Hepatitis D Virus Allow It to Escape Detection by CD8⁺ T Cells and Evolve at the Population Level

In: Gastroenterology Vol. 156 (2019) Nr. 6, pp. 1820 - 1833

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Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS-Mutant Pancreatic and Colorectal Cancer

In: Cancer Research Vol. 79 (2019) Nr. 9, pp. 2367 - 2378

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Final results of a multicenter, open-label phase 2 clinical trial (MYR203) to assess safety and efficacy of myrcludex B in cwith PEG-interferon Alpha 2a in patients with chronic HBV/HDV co-infection

In: Journal of Hepatology Vol. 70 (2019) Nr. 1 Suppl., pp. e81

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Prostate-specific membrane antigen ligand positron emission tomography in men with nonmetastatic castration-resistant prostate cancer

In: Clinical Cancer Research Vol. 25 (2019) Nr. 24, pp. 7448 - 7454

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Pexidartinib versus placebo for advanced tenosynovial giant cell tumour (ENLIVEN) : a randomised phase 3 trial

In: Lancet Vol. 394 (2019) Nr. 10197, pp. 478 - 487

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Juric, Dejan; Janku, Filip; Rodón, Jordi; Burris, Howard A.; Mayer, Ingrid A.; Schuler, Martin; Seggewiss-Bernhardt, Ruth; Gil-Martin, Marta; Middleton, Mark R.; Baselga, José; Bootle, Douglas; Demanse, David; Blumenstein, Lars; Schumacher, Karl; Huang, Alan; Quadt, Cornelia; Rugo, Hope S.

Alpelisib Plus Fulvestrant in PIK3CA -Altered and PIK3CA -Wild-Type Estrogen Receptor-Positive Advanced Breast Cancer : A Phase 1b Clinical Trial

In: JAMA Oncology Vol. 5 (2019) Nr. 2, pp. e184475

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Publisher Correction: Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 299

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Otxoa-de-Amezaga, Amaia; Miró-Mur, Francesc; Pedragosa, Jordi; Gallizioli, Mattia; Justicia, Carles; Gaja-Capdevila, Núria; Ruíz-Jaen, Francisca; Salas-Perdomo, Angélica; Bosch, Anna; Calvo, Maria; Márquez-Kisinousky, Leonardo; Denes, Adam; Gunzer, Matthias; Planas, Anna M.

Microglial cell loss after ischemic stroke favors brain neutrophil accumulation

In: Acta Neuropathologica Vol. 137 (2019) Nr. 2, pp. 321 - 341

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Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins

In: Cell Reports Vol. 27 (2019) Nr. 7, pp. 2092 - 2104.e10

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Machine learning-based predictors for immune checkpoint inhibitor therapy of non-small-cell lung cancer

In: Annals of Oncology Vol. 30 (2019) Nr. 4, pp. 655 - 657

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Reply [Letter to the Editor: Characterization of CD169+ Macrophages in Liver Regeneration: Tissue Distribution and Fate?]

In: Hepatology Vol. 70 (2019) Nr. 3, pp. 1074 - 1075

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Lindahl, Lise M.; Willerslev-Olsen, Andreas; Gjerdrum, Lise M.R.; Nielsen, Pia R.; Blümel, Edda; Rittig, Anne H.; Celis, Pamela; Herpers, Bjorn; Becker, Jürgen; Stausbøl-Grøn, Birgitte; Wasik, Mariusz A.; Gluud, Maria; Fredholm, Simon; Buus, Terkild B.; Johansen, Claus; Nastasi, Claudia; Peiffer, Lukas; Kubat, Linda; Bzorek, Michael; Eriksen, Jens O.; Krejsgaard, Thorbjørn; Bonefeld, Charlotte M.; Geisler, Carsten; Mustelin, Tomas; Langhoff, Erik; Givskov, Michael; Woetmann, Anders; Kilian, Mogens; Litman, Thomas; Iversen, Lars; Odum, Niels

Antibiotics inhibit tumor and disease activity in cutaneous T-cell lymphoma

In: Blood Vol. 134 (2019) Nr. 13, pp. 1072 - 1083

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Phung, Bengt; Cieśla, Maciej; Sanna, Adriana; Guzzi, Nicola; Beneventi, Giulia; Cao Thi Ngoc, Phuong; Lauss, Martin; Cabrita, Rita; Cordero, Eugenia; Bosch, Ana; Rosengren, Frida; Häkkinen, Jari; Griewank, Klaus; Paschen, Annette; Harbst, Katja; Olsson, Håkan; Ingvar, Christian; Carneiro, Ana; Tsao, Hensin; Schadendorf, Dirk; Pietras, Kristian; Bellodi, Cristian; Jönsson, Göran

The X-Linked DDX3X RNA Helicase Dictates Translation Reprogramming and Metastasis in Melanoma

In: Cell Reports Vol. 27 (2019) Nr. 12, pp. 3573 - 3586.e7

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Jachimowicz, Ron D.; Beleggia, Filippo; Isensee, Jörg; Velpula, Bhagya Bhavana; Goergens, Jonas; Bustos, Matias A.; Doll, Markus A.; Shenoy, Anjana; Checa-Rodriguez, Cintia; Wiederstein, Janica Lea; Baranes-Bachar, Keren; Bartenhagen, Christoph; Hertwig, Falk; Teper, Nizan; Nishi, Tomohiko; Schmitt, Anna; Distelmaier, Felix; Lüdecke, Hermann-Josef; Albrecht, Beate; Krüger, Marcus; Schumacher, Björn; Geiger, Tamar; Hoon, Dave S.B.; Huertas, Pablo; Fischer, Matthias; Hucho, Tim; Peifer, Martin; Ziv, Yael; Reinhardt, H. Christian; Wieczorek, Dagmar; Shiloh, Yosef

UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors

In: Cell Vol. 176 (2019) Nr. 3, pp. 505 - 519.e22

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Schadendorf, Dirk; Hauschild, Axel; Santinami, Mario; Atkinson, Victoria; Mandalà, Mario; Chiarion-Sileni, Vanna; Larkin, James; Nyakas, Marta; Dutriaux, Caroline; Haydon, Andrew; Robert, Caroline; Mortier, Laurent; Lesimple, Thierry; Plummer, Ruth; Schachter, Jacob; Dasgupta, Kohinoor; Manson, Stephanie; Koruth, Roy; Mookerjee, Bijoyesh; Kefford, Richard; Dummer, Reinhard; Kirkwood, John M.; Long, Georgina V.

Patient-reported outcomes in patients with resected, high-risk melanoma with BRAFV600E or BRAFV600K mutations treated with adjuvant dabrafenib plus trametinib (COMBI-AD) : a randomised, placebo-controlled, phase 3 trial

In: The Lancet Oncology Vol. 20 (2019) Nr. 5, pp. 701 - 710

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Merz, Simon F.; Korste, Sebastian; Bornemann, Lea; Michel, Lars; Stock, Pia; Squire, Anthony; Soun, Camille; Engel, Daniel Robert; Detzer, Julia; Lörchner, Holger; Hermann, Dirk M.; Kamler, Markus; Klode, Joachim; Hendgen-Cotta, Ulrike B.; Rassaf, Tienush; Gunzer, Matthias; Totzeck, Matthias

Publisher Correction: Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response

In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 2768

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Totzeck, Matthias; Mahabadi, Amir Abbas; Schlosser, Thomas Wilfried; Rassaf, Tienush

Weightlifting unmasks high-risk coronary anomaly

In: European Heart Journal Vol. 40 (2019) Nr. 1, pp. 72

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Krawczyk, Adalbert; Bazinet, Michel; Pantea, Victor; Cotler, Scott; Dahari, Harel; Shekhtman, Louis; Jimbei, Pavlina; Cojuhari, Lilia; Cebotarescu, Valentin; Uprichard, Susan; Vaillant, Andrew

Understanding HDV and HBsAg kinetics during nucleic acid polymer REP 2139 mono-therapy in HBeAg-negative chronic HBV/HDV co-infected patients via mathematical modeling

In: Journal of Hepatology Vol. 70 (2019) Nr. 1 Suppl., pp. e463

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Gröschel, Stefan; Hübschmann, Daniel; Raimondi, Francesco; Horak, Peter; Warsow, Gregor; Fröhlich, Martina; Klink, Barbara; Gieldon, Laura; Hutter, Barbara; Kleinheinz, Kortine; Bonekamp, David; Marschal, Oliver; Chudasama, Priya; Mika, Jagoda; Groth, Marie; Uhrig, Sebastian; Krämer, Stephen; Heining, Christoph; Heilig, Christoph E.; Richter, Daniela; Reisinger, Eva; Pfütze, Katrin; Eils, Roland; Wolf, Stephan; Kalle, Christof von; Brandts, Christian; Scholl, Claudia; Weichert, Wilko; Richter, Stephan; Bauer, Sebastian; Penzel, Roland; Schröck, Evelin; Stenzinger, Albrecht; Schlenk, Richard F.; Brors, Benedikt; Russell, Robert B.; Glimm, Hanno; Schlesner, Matthias; Fröhling, Stefan

Defective homologous recombination DNA repair as therapeutic target in advanced chordoma

In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 1635

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Urbonas, Vincas; Schadendorf, Dirk; Zimmer, Lisa; Danson, Sarah J.; Marshall, Ernest; Corrie, Pippa G.; Wheater, Matthew J.; Plummer, E.; Mauch, Cornelia; Scudder, Claire; Goff, Matthew; Love, Sharon B.; Mohammed, S.B.; Middleton, Mark R.

Paclitaxel with or without trametinib or pazopanib in advanced wild-type BRAF melanoma (PACMEL) : a multicentre, open-label, randomised, controlled phase II trial

In: Annals of Oncology Vol. 30 (2019) Nr. 2, pp. 317 - 324

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Fendler, Wolfgang P.; Calais, Jeremie; Eiber, Matthias; Flavell, Robert R.; Mishoe, Ashley; Feng, Felix Y.; Nguyen, Hao G.; Reiter, Robert E.; Rettig, Matthew B.; Okamoto, Shozo; Emmett, Louise; Zacho, Helle D.; Ilhan, Harun; Wetter, Axel; Rischpler, Christoph; Schoder, Heiko; Burger, Irene A.; Gartmann, Jeannine; Smith, Raven; Small, Eric J.; Slavik, Roger; Carroll, Peter R.; Herrmann, Ken; Czernin, Johannes; Hope, Thomas A.

Assessment of ⁶⁸Ga-PSMA-11 PET Accuracy in Localizing Recurrent Prostate Cancer : A Prospective Single-Arm Clinical Trial

In: JAMA Oncology Vol. 5 (2019) Nr. 6, pp. 856 - 863

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Yang, Dian; Qu, Fangfei; Cai, Hongchen; Chuang, Chen-Hua; Lim, Jing Shan; Jahchan, Nadine; Grüner, Barbara M.; Kuo, Christin S.; Kong, Christina; Oudin, Madeleine J.; Winslow, Monte M.; Sage, Julien; S. Kuo, Christin

Axon-like protrusions promote small cell lung cancer migration and metastasis

In: eLife Vol. 8 (2019) pp. e50616

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Quambusch, Lena; Landel, Ina; Depta, Laura; Weisner, Jörn; Uhlenbrock, Niklas; Müller, Matthias P.; Glanemann, Franziska; Althoff, Kristina; Siveke, Jens; Rauh, Daniel

Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity

In: Angewandte Chemie International Edition Vol. 58 (2019) Nr. 52, pp. 18823 - 18829

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EAU–ESMO consensus statements on the management of advanced and variant bladder cancer - an international collaborative multi-stakeholder effort : under the auspices of the EAU and ESMO Guidelines Committees

In: Annals of Oncology Vol. 30 (2019) Nr. 11, pp. 1697 - 1727

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Fleming, Viktor; Hu, Xiaoying; Weller, Céline; Weber, Rebekka; Groth, Christopher; Riester, Zeno; Hüser, Laura; Sun, Qian; Nagibin, Vasyl; Kirschning, Carsten Jürgen; Bronte, Vincenzo; Utikal, Jochen; Altevogt, Peter; Umansky, Viktor

Melanoma extracellular vesicles generate immunosuppressive myeloid cells by upregulating PD-L1 via TLR4 signaling

In: Cancer Research Vol. 79 (2019) Nr. 18, pp. 4715 - 4728

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Dmitrieva-Posocco, Oxana; Dzutsev, Amiran; Posocco, David F.; Hou, Vivianty; Yuan, Wuxing; Thovarai, Vishal; Mufazalov, Ilgiz A.; Gunzer, Matthias; Shilovskiy, Igor P.; Khaitov, Musa R.; Trinchieri, Giorgio; Waisman, Ari; Grivennikov, Sergei I.

Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer

In: Immunity Vol. 50 (2019) Nr. 1, pp. 166 - 180.e7

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Jackstadt, Rene; van Hooff, Sander R.; Leach, Joshua D.; Cortes-Lavaud, Xabier; Lohuis, Jeroen O.; Ridgway, Rachel A.; Wouters, Valérie M.; Roper, Jatin; Kendall, Timothy J.; Roxburgh, Campbell S.; Horgan, Paul G.; Nixon, Colin; Nourse, Craig; Gunzer, Matthias; Clark, William; Hedley, Ann; Yilmaz, Omer H.; Rashid, Mamunur; Bailey, Peter; Biankin, Andrew V.; Campbell, Andrew D.; Adams, David J.; Barry, Simon T.; Steele, Colin W.; Medema, Jan Paul; Sansom, Owen J.

Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis

In: Cancer Cell Vol. 36 (2019) Nr. 3, pp. 319 - 336.e7

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Yang, Shangqing; Wang, Lu; Pan, Wen; Bayer, Wibke; Thoens, Christine; Heim, Kathrin; Dittmer, Ulf; Timm, Jörg; Wang, Qin; Yu, Qing; Luo, Jinzhuo; Liu, Yanan; Hofmann, Maike; Thimme, Robert; Zhang, Xiaoyong; Chen, Hongtao; Wang, Hua; Feng, Xuemei; Yang, Xuecheng; Lu, Yinping; Lu, Mengji; Yang, Dongliang; Liu, Jia

MMP2/MMP9-mediated CD100 shedding is crucial for inducing intrahepatic anti-HBV CD8 T cell responses and HBV clearance

In: Journal of Hepatology Vol. 71 (2019) Nr. 4, pp. 685 - 698

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Merz, Simon F.; Korste, Sebastian; Bornemann, Lea; Michel, Lars; Stock, Pia; Squire, Anthony; Soun, Camille; Engel, Daniel Robert; Detzer, Julia; Lörchner, Holger; Hermann, Dirk M.; Kamler, Markus; Klode, Joachim; Hendgen-Cotta, Ulrike B.; Rassaf, Tienush; Gunzer, Matthias; Totzeck, Matthias

Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response

In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 2312

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Schadendorf, Dirk; Melanoma GWAS Consortium

Publisher Correction : Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 299

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Toffalori, Cristina; Zito, Laura; Gambacorta, Valentina; Riba, Michaela; Oliveira, Giacomo; Bucci, Gabriele; Barcella, Matteo; Spinelli, Orietta; Greco, Raffaella; Crucitti, Lara; Cieri, Nicoletta; Noviello, Maddalena; Manfredi, Francesco; Montaldo, Elisa; Ostuni, Renato; Naldini, Matteo M.; Gentner, Bernhard; Waterhouse, Miguel; Zeiser, Robert; Finke, Jürgen; Hanoun, Maher; Beelen, Dietrich; Gojo, Ivana; Luznik, Leo; Onozawa, Masahiro; Teshima, Takanori; Devillier, Raynier; Blaise, Didier; Halkes, Constantijn J.M.; Griffioen, Marieke; Carrabba, Matteo G.; Bernardi, Massimo; Peccatori, Jacopo; Barlassina, Cristina; Stupka, Elia; Lazarevic, Dejan; Tonon, Giovanni; Rambaldi, Alessandro; Cittaro, Davide; Bonini, Chiara; Fleischhauer, Katharina; Ciceri, Fabio; Vago, Luca

Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation

In: Nature Medicine Vol. 25 (2019) Nr. 4, pp. 603 - 611

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Schuler, Martin; Cho, Byoung Chul; Sayehli, Cyrus Michael; Navarro, Alejandro; Soo, Ross A.; Richly, Heike; Cassier, Philippe Alexandre; Tai, David; Penel, Nicolas; Nogova, Lucia; Park, Se Hoon; Schostak, Martin; Gajate, Pablo; Cathomas, Richard; Rajagopalan, Prabhu; Grevel, Joachim; Bender, Sebastian; Boix, Oliver; Nogai, Hendrik; Ocker, Matthias; Ellinghaus, Peter; Joerger, Markus

Rogaratinib in patients with advanced cancers selected by FGFR mRNA expression : a phase 1 dose-escalation and dose-expansion study

In: The Lancet Oncology Vol. 20 (2019) Nr. 10, pp. 1454 - 1466

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Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4) : A randomised, phase 2/3 trial

In: Lancet Vol. 393 (2019) Nr. 10184, pp. 1948 - 1957

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Ascierto, Paolo A.; Long, Georgina V.; Robert, Caroline; Brady, Benjamin; Dutriaux, Caroline; Di Giacomo, Anna Maria; Mortier, Laurent; Hassel, Jessica C.; Rutkowski, Piotr; McNeil, Catriona; Kalinka-Warzocha, Ewa; Savage, Kerry J.; Hernberg, Micaela M.; Lebbé, Celeste; Charles, Julie; Mihalcioiu, Catalin; Chiarion-Sileni, Vanna; Mauch, Cornelia; Cognetti, Francesco; Ny, Lars; Arance, Ana; Svane, Inge Marie; Schadendorf, Dirk; Gogas, Helen; Saci, Abdel; Jiang, Joel; Rizzo, Jasmine; Atkinson, Victoria

Survival Outcomes in Patients with Previously Untreated BRAF Wild-Type Advanced Melanoma Treated with Nivolumab Therapy : Three-Year Follow-up of a Randomized Phase 3 Trial

In: JAMA Oncology Vol. 5 (2019) Nr. 2, pp. 187 - 194

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Niemeyer, Johannes; Mentrup, Torben; Heidasch, Ronny; Müller, Stephan A; Biswas, Uddipta; Meyer, Rieke; Papadopoulou, Alkmini A.; Dederer, Verena; Haug-Kröper, Martina; Adamski, Vivian; Lüllmann-Rauch, Renate; Bergmann, Martin; Mayerhofer, Artur; Saftig, Paul; Wennemuth, Gunther; Jessberger, Rolf; Fluhrer, Regina; Lichtenthaler, Stefan F.; Lemberg, Marius K.; Schröder, Bernd

The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban

In: EMBO Reports Vol. 20 (2019) Nr. 3, pp. e46449

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Schadendorf, Dirk; Livingstone, Elisabeth; Zimmer, Lisa

Treatment in metastatic melanoma : Time to re-think

In: Annals of Oncology Vol. 30 (2019) Nr. 4, pp. 501 - 503

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Atkinson, Victoria G.; Hauschild, Axel; Santinami, Mario; Mandala, Mario; Chiarion Sileni, Vanna; Larkin, James M. G.; Nyakas, Marta S.; Dutriaux, Caroline; Haydon, Andrew M. M.; Mortier, Laurent; Robert, Caroline; Schachter, Jacob M.; Schadendorf, Dirk; Feng, X.; Jong, Egbert de; Mookerjee, Bijoyesh P.; Kefford, Rick F.; Dummer, Reinhard G.; Kirkwood, John M.; Long, Georgina V.

Adverse events (AEs) over time in patients (pts) treated with adjuvant dabrafenib plus trametinib (D + T) or placebo (Pbo) in the COMBI-AD trial

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii446

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Grob, Jean Jacques; Garbe, Claus; Ascierto, Paolo; Larkin, James; Dummer, Reinhard; Schadendorf, Dirk

Adjuvant melanoma therapy with new drugs : Should physicians continue to focus on metastatic disease or use it earlier in primary melanoma?

In: The Lancet Oncology Vol. 19 (2018) Nr. 12, pp. e720 - e725

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Bone sarcomas : ESMO-PaedCan-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 4, pp. iv79 - iv95

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Díaz-Carballo, David; Saka, Sahitya; Klein, Jacqueline; Rennkamp, Tobias; Acikelli, Ali H.; Malak, Sascha; Jastrow, Holger; Wennemuth, Gunther; Tempfer, Clemens; Schmitz, Inge; Tannapfel, Andrea; Strumberg, Dirk

A distinct oncogenerative multinucleated cancer cell serves as a source of stemness and tumor heterogeneity

In: Cancer Research Vol. 78 (2018) Nr. 9, pp. 2318 - 2331

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Kugel, Curtis H.; Douglass, Stephen M.; Webster, Marie R.; Kaur, Amanpreet; Liu, Qin; Yin, Xiangfan; Weiss, Sarah A.; Darvishian, Farbod; Al-Rohil, Rami N.; Ndoye, Abibatou; Behera, Reeti; Alicea, Gretchen M.; Ecker, Brett L.; Fane, Mitchell; Allegrezza, Michael J.; Svoronos, Nikolaos; Kumar, Vinit; Wang, Daniel Y.; Somasundaram, Rajasekharan; Hu-Lieskovan, Siwen; Ozgun, Alpaslan; Herlyn, Meenhard; Conejo-Garcia, Jose R.; Gabrilovich, Dmitry; Stone, Erica L.; Nowicki, Theodore S.; Sosman, Jeffrey; Rai, Rajat; Carlino, Matteo S.; Long, Georgina V.; Marais, Richard; Ribas, Antoni; Eroglu, Zeynep; Davies, Michael A.; Schilling, Bastian; Schadendorf, Dirk; Xu, Wei; Amaravadi, Ravi K.; Menzies, Alexander M.; McQuade, Jennifer L.; Johnson, Douglas B.; Osman, Iman; Weeraratna, Ashani T.

Age correlates with response to anti-PD1, reflecting age-related differences in intratumoral effector and regulatory T-Cell populations

In: Clinical Cancer Research Vol. 24 (2018) Nr. 21, pp. 5347 - 5356

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Fan, Kaiji; Ritter, Cathrin; Nghiem, Paul; Blom, Astrid; Verhaegen, Monique E.; Dlugosz, Andrzej; Ødum, Niels; Woetmann, Anders; Tothill, Richard W.; Hicks, Rodney J.; Sand, Michael; Schrama, David; Schadendorf, Dirk; Ugurel, Selma; Becker, Jürgen C.

Circulating cell-free miR-375 as surrogate marker of tumor burden in Merkel cell carcinoma

In: Clinical Cancer Research Vol. 24 (2018) Nr. 23, pp. 5873 - 5882

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Sauter, Reinhard J.; Sauter, Manuela; Reis, Edimara S.; Emschermann, Frederic N.; Nording, Henry; Ebenhöch, Sonja; Kraft, Peter; Münzer, Patrick; Mauler, Maximilian; Rheinlaender, Johannes; Madlung, Johannes; Edlich, Frank; Schäffer, Tilman E.; Meuth, Sven G.; Duerschmied, Daniel; Geisler, Tobias; Borst, Oliver; Gawaz, Meinrad; Kleinschnitz, Christoph; Lambris, John D.; Langer, Harald F.

Functional relevance of the anaphylatoxin receptor C3aR for platelet function and arterial thrombus formation marks an intersection point between innate immunity and thrombosis

In: Circulation Vol. 138 (2018) Nr. 16, pp. 1720 - 1735

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Adjuvant pembrolizumab versus placebo in resected stage III melanoma

In: The New England Journal of Medicine Vol. 378 (2018) Nr. 19, pp. 1789 - 1801

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Gulbins, Anne; Schumacher, Fabian; Becker, Katrin Anne; Wilker, Barbara; Soddemann, Matthias; Boldrin, Francesco; Müller, Christian P.; Edwards, Michael J.; Goodman, Michael; Caldwell, Charles C.; Kleuser, Burkhard; Kornhuber, Johannes; Szabo, Ildiko; Gulbins, Erich

Antidepressants regulate autophagy by targeting acid sphingomyelinase

In: Molecular Psychiatry Vol. 23 (2018) Nr. 12, pp. 2251

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Fanti, Stefano; Minozzi, Silvia; Antoch, Gerald; Banks, Ian; Briganti, Alberto; Carrio, Ignasi; Chiti, Arturo; Clarke, Noel; Eiber, Matthias; De Bono, Johann; Fizazi, Karim; Gillessen, Silke; Gledhill, Sam; Haberkorn, Uwe; Herrmann, Ken; Hicks, Rodney J.; Lecouvet, Frederic; Montironi, Rodolfo; Ost, Piet; O'Sullivan, Joe M.; Padhani, Anwar R.; Schalken, Jack A.; Scher, Howard I.; Tombal, Bertrand; van Moorselaar, Reindert Jeroen A.; Van Poppel, Heindrik; Vargas, Hebert Alberto; Walz, Jochen; Weber, Wolfgang A.; Wester, Hans-Jürgen; Oyen, Wim J.G.

Consensus on molecular imaging and theranostics in prostate cancer

In: The Lancet Oncology Vol. 19 (2018) Nr. 12, pp. e696 - e708

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McQuade, Jennifer L; Daniel, Carrie R; Hess, Kenneth R; Mak, Carmen; Wang, Daniel Y; Rai, Rajat R; Park, John J; Haydu, Lauren E; Spencer, Christine; Wongchenko, Matthew; Lane, Stephen; Lee, Dung-Yang; Kaper, Mathilde; McKean, Meredith; Beckermann, Kathryn E; Rubinstein, Samuel M; Rooney, Isabelle; Musib, Luna; Budha, Nageshwar; Hsu, Jessie; Nowicki, Theodore S; Avila, Alexandre; Haas, Tomas; Puligandla, Maneka; Lee, Sandra; Fang, Shenying; Wargo, Jennifer A; Gershenwald, Jeffrey E; Lee, Jeffrey E; Hwu, Patrick; Chapman, Paul B; Sosman, Jeffrey A; Schadendorf, Dirk; Grob, Jean-Jacques; Flaherty, Keith T; Walker, Dana; Yan, Yibing; McKenna, Edward; Legos, Jeffrey J; Carlino, Matteo S; Ribas, Antoni; Kirkwood, John M; Long, Georgina V; Johnson, Douglas B; Menzies, Alexander M; Davies, Michael A

Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy : a retrospective, multicohort analysis

In: The Lancet Oncology Vol. 19 (2018) Nr. 3, pp. 310 - 322

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George, Suzanne; Bauer, Sebastian; Jones, Robin L.; Serrano, Christina S.; Mehren, Margaret M. von; Kang, Y.-K.; Schöffski, Patrick; Cassier, Philippe A.; Eskens, Ferry A.; Mir, Olivier; Tap, William D.; Chawla, Sant P.; Rutkowski, Piotr; Shi, H.; Schmidt-Kittler, Oleg; Mar, B.; Heinrich, Michael

Correlation of ctDNA and response in patients (pts) with PDGFRα D842 GIST treated with avapritinib

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii584

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Küppers, Ralf; Stevenson, Freda K.

Critical influences on the pathogenesis of follicular lymphoma

In: Blood Vol. 131 (2018) Nr. 21, pp. 2297 - 2306

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DNA methylation-based classification of central nervous system tumours

In: Nature Vol. 555 (2018) Nr. 7697, pp. 469 - 474

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Langer, Samantha K; Cull, Alyssa; Wossidlo, Natalie; Klump, Hannes; Horn, Peter; Heinrichs, Stefan;

Distinct Gene Expression Patterns Drive Proliferation of Dominant-Negative RUNX1 Immortalized HSPCs
60th ASH Annual Meeting; December 1-4, 2018; San Diego, USA,

In: Blood Vol. 132 (2018) Nr. Supplement 1, pp. 1795 - 1795

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Dummer, Reinhard; Ascierto, Paolo A; Gogas, Helen J; Arance, Ana; Mandala, Mario; Liszkay, Gabriella; Garbe, Claus; Schadendorf, Dirk; Krajsova, Ivana; Gutzmer, Ralf; Chiarion-Sileni, Vanna; Dutriaux, Caroline; de Groot, Jan Willem B; Yamazaki, Naoya; Loquai, Carmen; Moutouh-de Parseval, Laure A; Pickard, Michael D; Sandor, Victor; Robert, Caroline; Flaherty, Keith T

Encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF-mutant melanoma (COLUMBUS) : a multicentre, open-label, randomised phase 3 trial

In: The Lancet Oncology Vol. 19 (2018) Nr. 5, pp. 603 - 615

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Krawczyk, Adalbert; et.al.

Establishment of High Rates of Functional Control and Reversal of Fibrosis Following Treatment of Hbeag Negative Chronic HBV Infection with REP 2139-Mg / REP 2165-Mg, Tenofovir Disoproxil Fumarate and Pegylated Interferon Alpha-2a

In: Hepatology Vol. 68 (2018) Nr. S1, pp. 234A - 235A

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Chen, Li Tzon; Macarulla, Teresa M.; Blanc, Jean Frédéric; Mirakhur, Beloo; Jong, Floris A. de; Belanger, Bruce; Bekaii-Saab, Tanios; Siveke, Jens

Impact of dose reduction or dose delay on the efficacy of liposomal irinotecan (nal-IRI)+5-fluorouracil/leucovorin (5-FU/LV) : Survival analysis from NAPOLI-1

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii250 - viii251

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Casali, P.G.; Abecassis, N.; Bauer, Sebastian; Biagini, R.; Bielack, S.; Bonvalot, S.; Boukovinas, I.; Bovee, J.V.M.G.; Brodowicz, T.; Broto, J.M.; Buonadonna, A.; De Álava, E.; Dei Tos, A.P.; Del Muro, X.G.; Dileo, P.; Eriksson, M.; Fedenko, A.; Ferraresi, V.; Ferrari, A.; Ferrari, S.; Frezza, A.M.; Gasperoni, S.; Gelderblom, H.; Gil, T.; Grignani, G.; Gronchi, A.; Haas, R.L.; Hannu, A.; Hassan, B.; Hohenberger, P.; Issels, R.; Joensuu, H.; Jones, R.L.; Judson, I.; Jutte, P.; Kaal, S.; Kasper, B.; Kopeckova, K.; Krákorová, D.A.; Le Cesne, A.; Lugowska, I.; Merimsky, O.; Montemurro, M.; Pantaleo, M.A.; Piana, R.; Picci, P.; Piperno-Neumann, S.; Pousa, A.L.; Reichardt, P.; Robinson, M.H.; Rutkowski, P.; Safwat, A.A.; Schöffski, P.; Sleijfer, S.; Stacchiotti, S.; Sundby Hall, K.; Unk, M.; Van Coevorden, F.; Van Der Graaf, W.; Whelan, J.; Wardelmann, E.; Zaikova, O.; Blay, J.Y.

Gastrointestinal stromal tumours: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 4, pp. iv68 - iv78

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Macarulla Mercade, Teresa; Bodoky, Gyorgy; Siveke, Jens; Lee, Kyung-hun; Chen, J.; Mirakhur, Beloo; Dean, Andrew; Chen, Li-Tzong; Jong, Floris A. de

NAPOLI-1 phase III trial outcomes by prior surgery, and disease stage, in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC)

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii249 - viii250

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Shen, Fang; Li, Yaming; Wang, Yang; Sozzi, Vitina; Revill, Peter A.; Liu, Jiangxia; Gao, Lu; Yang, Guang; Lu, Mengji; Sutter, Kathrin; Dittmer, Ulf; Chen, Jieliang; Yuan, Zhenghong

Hepatitis B virus sensitivity to interferon-α in hepatocytes is more associated with cellular interferon response than with viral genotype

In: Hepatology Vol. 67 (2018) Nr. 4, pp. 1237 - 1252

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Grünwald, Viktor; Schuler, Martin H.; Schöffski, Patrick; Kopp, Hans-Georg; Bauer, Sebastian; Kasper, Bernd; Lindner, Lars H.; Chemnitz, Jens M.; Crysandt, Martina; Stein, Alexander; Steffen, B.; Richter, Stephan; Kneba, Michael; Egerer, Gerlinde; Zimmermann, S.; Karch, Annika; Kunitz, Annegret

Health-related quality of life (HR-QoL) in elderly soft tissue sarcoma (STS) patients from the randomized phase II EPAZ study comparing pazopanib (PAZ) and doxorubicin (DOX) in first line

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii577

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Long, Georgina V.; Hauschild, Axel; Santinami, Mario; Atkinson, Victoria G.; Mandala, Mario; Chiarion-Sileni, Vanna; Larkin, James M. G.; Robert, Caroline; Schadendorf, Dirk; Dasgupta, Kohinoor; Shilkrut, Mark; Garrett, James; Brase, Jan C.; Kefford, Rick F.; Kirkwood, John M.; Dummer, Reinhard G.

Updated relapse-free survival (RFS) and biomarker analysis in the COMBI-AD trial of adjuvant dabrafenib + trametinib (D + T) in patients (pts) with resected BRAF V600-mutant stage III melanoma

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii734 - viii735

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Schadendorf, Dirk; et.al.

Updated relapse-free survival (RFS) and biomarker analysis in the COMBI-AD trial of adjuvant dabrafenib plus trametinib (D plus T) in patients (pts) with resected BRAF V600-mutant stage III melanoma

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An oncogenic axis of STAT-mediated BATF3 upregulation causing MYC activity in classical Hodgkin lymphoma and anaplastic large cell lymphoma

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Corrigendum: Mycobacteria exploit nitric oxide-induced transformation of macrophages into permissive giant cells

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Author Correction : The landscape of genomic alterations across childhood cancers

In: Nature Vol. 559 (2018) Nr. 7714, pp. E10

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Horst, Andrea Kristina; Wegscheid, Claudia; Schaefers, Christoph; Schiller, Birgit; Neumann, Katrin; Lunemann, Sebastian; Langeneckert, Annika E; Oldhafer, Karl J; Weiler-Normann, Christina; Lang, Karl S.; Singer, Bernhard B.; Altfeld, Marcus; Diehl, Linda; Tiegs, Gisa

Carcinoembryonic antigen-related cell adhesion molecule 1 controls IL-2-dependent regulatory T-cell induction in immune-mediated hepatitis in mice

In: Hepatology Vol. 68 (2018) Nr. 1, pp. 200 - 214

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Decreased appetite (DA) at baseline impacts prognosis in the NAPOLI-1 phase 3 study in metastatic pancreatic ductal adenocarcinoma (mPDAC)

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Estimate of long-term relapse-free survival (RFS) and analysis of baseline factors associated with RFS in the COMBI-AD trial

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Adjuvant vemurafenib in resected, BRAF mutation-positive melanoma (BRIM8) : a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial

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Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide

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Extrahepatic Comorbidities Do Not Alter the Safety and Efficacy of Radioembolization of NAFLD-Associated HCC

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Biased IGH VDJ gene repertoire and clonal expansions in B cells of chronically hepatitis C virus–infected individuals

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Helicobacter pylori adhesin HopQ disrupts trans dimerization in human CEACAMs

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Prognostic value of baseline biliary stents on outcomes in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) in the NAPOLI-1 trial

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CEACAM1 promotes CD8⁺ T cell responses and improves control of a chronic viral infection

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Functional CD169 on Macrophages Mediates Interaction with Dendritic Cells for CD8+ T Cell Cross-Priming

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IG-MYC⁺ neoplasms with precursor B-cell phenotype are molecularly distinct from Burkitt lymphomas

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B Cell-Mediated Maintenance of Cluster of Differentiation 169–Positive Cells Is Critical for Liver Regeneration

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Bayo, Juan; Tran, Tram Anh; Wang, Lei; Peña-Llopis, Samuel; Das, Amit K.; Martinez, Elisabeth D.

Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks

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Soft tissue and visceral sarcomas : ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 4, pp. iv51 - iv67

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Overall survival at 4 years of follow-up in a phase III trial of nivolumab plus ipilimumab combination therapy in advanced melanoma (CheckMate 067)

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii735

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The effect of best response to prior anticancer therapy on efficacy outcomes in the NAPOLI-1 trial of patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) previously treated with gemcitabine-based therapy

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 5, pp. v42

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Translational Insights into Gastrointestinal Stromal Tumor and Current Clinical Advances

In: Annals of Oncology Vol. 29 (2018) Nr. 10, pp. 2037 - 2045

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Bauer, Sebastian; George, Suzanne; Kang, Y.-K.; Tap, William D.; Zhou, T.; Picazio, N.; Boral, Andy L.; Heinrich, Michael

VOYAGER : An open-label, randomised, phase III study of avapritinib vs regorafenib in patients (pts) with locally advanced (adv) metastatic or unresectable gastrointestinal stromal tumour (GIST)

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Correction: Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa

In: Molecular Psychiatry Vol. 23 (2018) Nr. 9, pp. 1

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Mahabadi, Amir Abbas; Rassaf, Tienush

Imaging of coronary inflammation for cardiovascular risk prediction

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A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

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Clinical Relevance and Suppressive Capacity of Human Myeloid-Derived Suppressor Cell Subsets

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Consensus statement on mandatory measurements in pancreatic cancer trials (COMM-PACT) for systemic treatment of unresectable disease

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Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors

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Schadendorf, Dirk; Van Akkooi, Alexander; Berking, Carola; Griewank, Klaus; Gutzmer, Ralf; Hauschild, Axel; Stang, Andreas; Rösch, Alexander; Ugurel, Selma

Melanoma

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Overall survival in patients with BRAF-mutant melanoma receiving encorafenib plus binimetinib versus vemurafenib or encorafenib (COLUMBUS) : A multicentre, open-label, randomised, phase 3 trial

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A mechanistic classification of clinical phenotypes in neuroblastoma

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Role of elevated PHIP copy number as a prognostic and progression marker for cutaneous melanoma

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T cell receptor fingerprinting enables in-depth characterization of the interactions governing recognition of peptide–MHC complexes

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Activity and safety of crizotinib in patients with alveolar soft part sarcoma with rearrangement of TFE3 : European Organization for Research and Treatment of Cancer (EORTC) phase II trial 90101 'CREATE'

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Use of modern imaging methods to facilitate trials of metastasis-directed therapy for oligometastatic disease in prostate cancer : a consensus recommendation from the EORTC Imaging Group

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Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade

In: Cell Vol. 173 (2018) Nr. 3, pp. 624 - 633.e8

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Differential impact of pure glyphosate and glyphosate-based herbicide in a model of peripheral nervous system myelination

In: Acta Neuropathologica Vol. 136 (2018) Nr. 6, pp. 979 - 982

Online Full Text: dx.doi.org/
Schmidt, Stefan; Linge, Annett; Zwanenburg, Alex; Leger, Stefan; Lohaus, Fabian; Krenn, Constanze; Appold, Steffen; Gudziol, Volker; Nowak, Alexander; von Neubeck, Cläre; Tinhofer, Inge; Budach, Volker; Sak, Ali; Stuschke, Martin; Balermpas, Panagiotis; Rodel, Claus; Bunea, Hatice; Grosu, Anca-Ligia; Abdollahi, Amir; Debus, Jurgen; Ganswindt, Ute; Belka, Claus; Pigorsch, Steffi; Combs, Stephanie E.; Monnich, David; Zips, Daniel; Baretton, Gustavo B.; Buchholz, Frank; Baumann, Michael; Krause, Mechthild; Lock, Steffen

Development and Validation of a Gene Signature for Patients with Head and Neck Carcinomas Treated by Postoperative Radio(chemo)therapy

In: Clinical Cancer Research Vol. 24 (2018) Nr. 6, pp. 1364 - 1374

Online Full Text: dx.doi.org/ (Open Access)
Cheung, Phyllis F.; Neff, Florian; Neander, Christian; Bazarna, Anna; Savvatakis, Konstantinos; Liffers, Sven-Thorsten; Althoff, Kristina; Lee, Chang-Lung; Moding, Everett J.; Kirsch, David G.; Saur, Dieter; Bazhin, Alexandr V.; Trajkovic-Arsic, Marija; Heikenwalder, Mathias F.; Siveke, Jens

Notch-induced myeloid reprogramming in spontaneous pancreatic ductal adenocarcinoma by dual genetic targeting

In: Cancer Research Vol. 78 (2018) Nr. 17, pp. 4997 - 5010

Online Full Text: dx.doi.org/ (Open Access)
Griewank, Klaus G.; Koelsche, Christian; van de Nes, Johannes A. P.; Schrimpf, Daniel; Gessi, Marco; Möller, Inga; Sucker, Antje; Scolyer, Richard A.; Buckland, Michael E.; Murali, Rajmohan; Pietsch, Torsten; Deimling, Andreas von; Schadendorf, Dirk

Integrated genomic classification of melanocytic tumors of the central nervous system using mutation analysis, copy number alterations, and DNA methylation profiling

In: Clinical Cancer Research Vol. 24 (2018) Nr. 18, pp. 4494 - 4504

Online Full Text: dx.doi.org/ (Open Access)
Huckins, L.M.; Hatzikotoulas, K.; Southam, L.; Thornton, L.M.; Steinberg, J.; Aguilera-Mckay, F.; Treasure, J.; Schmidt, U.; Gunasinghe, C.; Romero, A.; Curtis, C.; Rhodes, D.; Moens, J.; Kalsi, G.; Dempster, D.; Leung, R.; Keohane, A.; Burghardt, R.; Ehrlich, S.; Hebebrand, Johannes; Hinney, Anke; Ludolph, A.; Walton, E.; Deloukas, P.; Hofman, A.; Palotie, A.; Palta, P.; Van Rooij, F.J.A.; Stirrups, K.; Adan, R.; Boni, C.; Cone, R.; Dedoussis, G.; Van Furth, E.; Gonidakis, F.; Gorwood, P.; Hudson, J.; Kaprio, J.; Kas, M.; Keski-Rahonen, A.; Kiezebrink, K.; Knudsen, G.-P.; Slof-Op 'T Landt, M.C.T.; Maj, M.; Monteleone, A.M.; Monteleone, P.; Raevuori, A.H.; Reichborn-Kjennerud, T.; Tozzi, F.; Tsitsika, A.; Van Elburg, A.; Collier, D.A.; Sullivan, P.F.; Breen, G.; Bulik, C.M.; Zeggini, E.

Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa

In: Molecular Psychiatry Vol. 23 (2018) Nr. 5, pp. 1169 - 1180

Online Full Text: dx.doi.org/ (Open Access)
Duffy, David L.; Zhu, Gu; Li, Xin; Sanna, Marianna; Iles, Mark M.; Jacobs, Leonie C.; Evans, David M.; Yazar, Seyhan; Beesley, Jonathan; Law, Matthew H.; Kraft, Peter; Visconti, Alessia; Taylor, John C.; Lui, Fan; Wright, Margaret J.; Henders, Anjali K.; Bowdler, Lisa; Glass, Dan; Ikram, Arfan M.; Uitterlinden, André G.; Madden, Pamela A.; Heath, Andrew C.; Nelson, Elliot C.; Green, Adele C.; Chanock, Stephen; Barrett, Jennifer H.; Brown, Matthew A.; Hayward, Nicholas K.; MacGregor, Stuart; Sturm, Richard A.; Hewitt, Alex W.; Lee, Jeffrey E.; Brossard, Myriam; Moses, Eric K.; Song, Fengju; Kumar, Rajiv; Easton, Douglas F.; Pharoah, Paul D. P.; Swerdlow, Anthony J.; Kypreou, Katerina P.; Harland, Mark; Randerson-Moor, Juliette; Akslen, Lars A.; Andresen, Per A.; Avril, Marie-Françoise; Azizi, Esther; Scarrà, Giovanna Bianchi; Brown, Kevin M.; Dębniak, Tadeusz; Elder, David E.; Fang, Shenying; Friedman, Eitan; Galan, Pilar; Ghiorzo, Paola; Gillanders, Elizabeth M.; Goldstein, Alisa M.; Gruis, Nelleke A.; Hansson, Johan; Helsing, Per; Hočevar, Marko; Höiom, Veronica; Ingvar, Christian; Kanetsky, Peter A.; Chen, Wei V.; Landi, Maria Teresa; Lang, Julie; Lathrop, G. Mark; Lubiński, Jan; Mackie, Rona M.; Mann, Graham J.; Molven, Anders; Novaković, Srdjan; Olsson, Håkan; Puig, Susana; Puig-Butille, Joan Anton; Radford-Smith, Graham L.; van der Stoep, Nienke; van Doorn, Remco; Whiteman, David C.; Craig, Jamie E.; Schadendorf, Dirk; Simms, Lisa A.; Burdon, Kathryn P.; Nyholt, Dale R.; Pooley, Karen A.; Orr, Nicholas; Stratigos, Alexander J.; Cust, Anne E.; Ward, Sarah V.; Schulze, Hans-Joachim; Dunning, Alison M.; Demenais, Florence; Amos, Christopher I.; Kayser, Manfred; Hunter, David J.; Newton Bishop, Julia A.; Spector, Timothy D.; Montgomery, Grant W.; Mackey, David A.; Smith, George Davey; Nijsten, Tamar E.; Bishop, D. Timothy; Bataille, Veronique; Falchi, Mario; Han, Jiali; Martin, Nicholas G.

Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

In: Nature Communications Vol. 9 (2018) Nr. 1, pp. 4774

Online Full Text: dx.doi.org/ (Open Access)
Hodi, Frank Stephen; Chiarion-Sileni, Vanna; Gonzalez, Rene; Grob, Jean-Jacques; Rutkowski, Piotr; Cowey, Charles Lance; Lao, Christopher D; Schadendorf, Dirk; Wagstaff, John; Dummer, Reinhard; Ferrucci, Pier Francesco; Smylie, Michael; Hill, Andrew; Hogg, David; Marquez-Rodas, Ivan; Jiang, Joel; Rizzo, Jasmine; Larkin, James; Wolchok, Jedd D

Nivolumab plus ipilimumab or nivolumab alone versus ipilimumab alone in advanced melanoma (CheckMate 067) : 4-year outcomes of a multicentre, randomised, phase 3 trial

In: The Lancet Oncology Vol. 19 (2018) Nr. 11, pp. 1480 - 1492

Online Full Text: dx.doi.org/
Becker-Flegler, Katrin; Riethmüller, Joachim; Seitz, Aaron P.; Gardner, Aaron; Boudreau, Ryan; Kamler, Markus; Kleuser, Burkhard; Schuchman, Edward; Caldwell, Charles C.; Edwards, Michael J.; Grassmé, Heike; Brodlie, Malcolm; Gulbins, Erich

Sphingolipids as targets for inhalation treatment of cystic fibrosis

In: Advanced Drug Delivery Reviews Vol. 133 (2018) pp. 66 - 75

Online Full Text: dx.doi.org/
Gröbner, Susanne N.; Worst, Barbara C.; Weischenfeldt, Joachim; Buchhalter, Ivo; Kleinheinz, Kortine; Rudneva, Vasilisa A.; Johann, Pascal D.; Balasubramanian, Gnana Prakash; Segura-Wang, Maia; Brabetz, Sebastian; Bender, Sebastian; Hutter, Barbara; Sturm, Dominik; Pfaff, Elke; Hübschmann, Daniel; Zipprich, Gideon; Heinold, Michael; Eils, Jürgen; Lawerenz, Christian; Erkek, Serap; Lambo, Sander; Waszak, Sebastian; Blattmann, Claudia; Borkhardt, Arndt; Kuhlen, Michaela; Eggert, Angelika; Fulda, Simone; Gessler, Manfred; Wegert, Jenny; Kappler, Roland; Baumhoer, Daniel; Burdach, Stefan; Kirschner-Schwabe, Renate; Kontny, Udo; Kulozik, Andreas E.; Lohmann, Dietmar; Hettmer, Simone; Eckert, Cornelia; Bielack, Stefan; Nathrath, Michaela; Niemeyer, Charlotte; Richter, Günther H.; Schulte, Johannes; Siebert, Reiner; Westermann, Frank; Molenaar, Jan J.; Vassal, Gilles; Witt, Hendrik; Zapatka, Marc; Burkhardt, Birgit; Kratz, Christian P.; Witt, Olaf; Tilburg, Cornelis M. Van; Kramm, Christof M.; Fleischhack, Gudrun; Dirksen, Uta; Rutkowski, Stefan; Frühwald, Michael; Hoff, Katja Von; Wolf, Stephan; Klingebiel, Thomas; Koscielniak, Ewa; Landgraf, Pablo; Koster, Jan; Resnick, Adam C.; Zhang, Jinghui; Liu, Yanling; Zhou, Xin; Waanders, Angela J.; Zwijnenburg, Danny A.; Raman, Pichai; Brors, Benedikt; Weber, Ursula D.; Northcott, Paul A.; Pajtler, Kristian; Kool, Marcel; Piro, Rosario M.; Korbel, Jan O.; Schlesner, Matthias; Eils, Roland; Jones, David T. W.; Lichter, Peter; Chavez, Lukas; Pfister, Stefan M.

The landscape of genomic alterations across childhood cancers

In: Nature Vol. 555 (2018) Nr. 7696, pp. 321 - 327

Online Full Text: dx.doi.org/ (Open Access)
Chudasama, Priya; Mughal, Sadaf S.; Schröck, Evelin; Glimm, Hanno; Kleinheinz, Kortine; Klink, Barbara; Brors, Benedikt; Hlevnjak, Mario; Gröschel, Stefan; Wolf, Stephan; Omlor, Georg; Ernst, Aurélie; Ulrich, Alexis; Deeg, Katharina I.; Mechtersheimer, Gunhild; Schimmack, Simon; Eils, Roland; Egerer, Gerlinde; Kasper, Bernd; Wong, Siao-Han; von Kalle, Christof; Hohenberger, Peter; Lehner, Burkhard; Rippe, Karsten; Chung, Inn; Bauer, Sebastian; Scholl, Claudia; Sieverling, Lina; Sanders, Mathijs A.; Hübschmann, Daniel; Heilig, Christoph E.; Hutter, Barbara; Renner, Marcus; Weichert, Wilko; Stenzinger, Albrecht; Schlesner, Matthias; Hoogenboezem, Remco M.; Kopp, Hans-Georg; Rabe, Sophie; Zapatka, Marc; Fröhling, Stefan

Integrative genomic and transcriptomic analysis of leiomyosarcoma

In: Nature Communications Vol. 9 (2018) Nr. 1, pp. 144

Online Full Text: dx.doi.org/ (Open Access)
Jockenhöfer, Finja; Schimming, Tobias T.; Schaller, Jörg; Moege, Jürgen; Livingstone, Elisabeth; Salva, Katrin A.; Zimmer, Lisa; Schadendorf, Dirk; Rösch, Alexander

Sebaceous tumours: more than skin deep

In: Gut Vol. 67 (2018) Nr. 11, pp. 2045 - 2053

Online Full Text: dx.doi.org/
Migden, Michael R.; Rischin, Danny; Schmults, Chrysalyne D.; Guminski, Alexander; Hauschild, Axel; Lewis, Karl D.; Chung, Christine H.; Hernandez-Aya, Leonel; Lim, Annette M.; Chang, Anne Lynn S.; Rabinowits, Guilherme; Thai, Alesha A.; Dunn, Lara A.; Hughes, Brett G.M.; Khushalani, Nikhil I.; Modi, Badri; Schadendorf, Dirk; Gao, Bo; Seebach, Frank; Li, Siyu; Li, Jingjin; Mathias, Melissa; Booth, Jocelyn; Mohan, Kosalai; Stankevich, Elizabeth; Babiker, Hani M.; Brana, Irene; Gil-Martin, Marta; Homsi, Jade; Johnson, Melissa L.; Moreno, Victor; Niu, Jiaxin; Owonikoko, Taofeek K.; Papadopoulos, Kyriakos P.; Yancopoulos, George D.; Lowy, Israel; Fury, Matthew G.

PD-1 blockade with cemiplimab in advanced cutaneous squamous-cell carcinoma

In: The New England Journal of Medicine Vol. 379 (2018) Nr. 4, pp. 341 - 351

Online Full Text: dx.doi.org/ Online Full Text (Open Access)

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