ZMB Site - Medical Faculty / University Hospital Essen

ZMB Research
Sites

Medical Faculty / University Hospital Essen

Selected Publications

Prof. Dr.Sebastian Bauer

Group: Translational Sarcoma Research

ZMB Research Program: Oncology

Prof. Dr. Dr.Jürgen Becker

Group: Translational Skin Cancer Research

ZMB Research Program: Oncology

Prof. Dr.Ivo Bendix

Group: Experimental Perinatal Neuroscience

Prof. Dr. Dr.Sven Brandau

Group:Otorhinolaryngology

ZMB Research Program: Oncology

Prof. Dr.Jan Buer

Director of: Institute of Medical Microbiology

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Elke Cario

Group: Experimental Gastroenterology

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Ulf Dittmer

Director of: Institute of Virology

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Nicole Dünker

Group: Neuroanatomy

ZMB Research Program: Molecular and Chemical Cell Biology

Prof. Dr.Joachim Fandrey

Director of: Institute of Physiology

ZMB Research Program: Molecular and Chemical Cell Biology

Jun.-Prof. Dr.Katja Ferenz

Group: Institute of Physiology

ZMB Research Program: Molecular and Chemical Cell Biology

Prof. Dr.Katharina Fleischhauer

Director of: Institute for Experimental Cellular Therapy

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Stefanie Flohé

Group: Immunology Sepsis/Trauma

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Dagmar Führer-Sakel

Director of: Clinic for Endocrinology, Diabetology and Metabolism

ZMB Research Program: Oncology

Prof. Dr.Bernd Giebel

Group: Giebel Lab

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Barbara M. Grüner

Group: Molecular Tumorpathology

ZMB Research Program: Oncology

Prof. Dr.Barbara Grünwald

Group: Tumor Heterogeneity and Translational Systems Biology

ZMB Research Program: Oncology

Prof. Dr.Erich Gulbins

Director of: Department of Molecular Biology

ZMB Research Program: Oncology

Prof. Dr.Matthias Gunzer

Director of: Institute of Experimental Immunology & Imaging

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Wiebke Hansen

Group: Molecular Infection Immunology

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Ulrike Hendgen-Cotta

Manager of: Cardio Science Labs

ZMB Research Program: Molecular and Chemical Cell Biology

Prof. Dr.Dirk M. Hermann

Group: Vascular Neurology, Dementia and Age Research

ZMB Research Program: Molecular and Chemical Cell Biology

Prof. Dr.Ken Herrmann

Group: Clinic for Nuclear Medicine

ZMB Research Program: Oncology

Prof. Dr.Heike Heuer

Group: Molecular Thyroidology

ZMB Research Program: Molecular and Chemical Cell Biology

PD Dr.Josephine Herz

Group: Experimental Perinatal Neuroscience

ZMB Research Program: Molecular and Chemical Cell Biology

Prof. Dr.Anke Hinney

Group: LVR Clinic for Psychiatry Essen

ZMB Research Program: Molecular and Chemical Cell Biology

Prof. Dr.Peter Horn

Director of: Institute for Transfusion Medicine

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.George Iliakis

Group: Radiation Biology

ZMB Research Program: Oncology

Prof. Dr.Jadwiga Jablonska-Koch

Group:Otorhinolaryngology (ENT)

ZMB Research Program: Oncology

Prof. Dr.Verena Jendrossek

Group: Molecular Cell Biology

ZMB Research Program: Oncology

Prof. Dr.Carsten Kirschning

Group: Regulation of Pathogen-specific Immunity

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Diana Klein

Group: Vascular Remodeling & Normal Tissue Protection

ZMB Research Program: Oncology

Prof. Dr.Christoph Kleinschnitz

Director of: Clinic for Neurology

ZMB Research Program: Molecular and Chemical Cell Biology

PD Dr.Adalbert Krawczyk

Group: Clinic for Infectious Diseases

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Ralf Küppers

Director of: Institute of Cell Biology (Tumor Research)

ZMB Research Program: Oncology

Prof. Dr.Karl Sebastian Lang

Director of: Institute of Immunology

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Jun.-Prof. Dr.Elisabeth Littwitz-Salomon

Group: Immune Metabolism in Infection and Cancer

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Dietmar Lohmann

Group: Ophthalmic Oncology and Genetics

ZMB Research Program: Molecular and Chemical Cell Biology

Prof. Dr.Katharina Lückerath

Group: Preclinical Theranostics in Nuclear Medicine

ZMB Research Program: Oncology

PD Dr.Johann Matschke

Group: Metabolism and Radiation Response

ZMB Research Program: Oncology

Prof. Dr.Annette Paschen

Group: Molecular Tumor Immunology

ZMB Research Program: Oncology

Dr.Samuel Peña-Llopis

Junior Group: Translational Genomics in Solid Tumors

ZMB Research Program: Oncology

Prof. Dr.Tienush Rassaf

Director of: Clinic for Cardiology and Vascular Medicine

ZMB Research Program: Oncology

Prof. Dr.Christian Reinhardt

Director of: Clinic for Hematology and Stem Cell Transplantation

ZMB Research Program: Oncology

Prof. Dr.Alexander Roesch

Group: Tumor Heterogeneity & Plasticity

ZMB Research Program: Oncology

Prof. Dr.Dirk Schadendorf

Director of: Clinic for Dermatology

ZMB Research Program: Oncology

Prof. Dr.Björn Scheffler

Group: Translational Neurooncology

ZMB Research Program: Oncology

Prof. Dr.Alexander Schramm

Group: Molecular Oncology

ZMB Research Program: Oncology

Prof. Dr.Martin Schuler

Director of: Department of Medical Oncology

ZMB Research Program: Oncology

Prof. Dr.Winfried Siffert

Director of: Institute of Pharmacogenetics

ZMB Research Program: Molecular and Chemical Cell Biology

Prof. Dr. Dr.Jens Siveke

Group: Bridge Institute for Experimental Tumor Therapy

ZMB Research Program: Oncology

PD Dr.Kathrin Sutter

TRR60 Junior Research Group: Interferone-alpha Subtypes

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr. Dr.Alpaslan Tasdogan

Group: Tumor Metabolism

ZMB Research Program: Oncology

PD Dr.Basant Kumar Thakur

Group: Cancer Exosome Research Lab

ZMB Research Program: Oncology

Prof. Dr.Kathrin Thedieck

Group: Metabolism, Senescence and Autophagy

ZMB Research Program: Molecular and Chemical Cell Biology

Dr.Silvia Vega-Rubín-de-Celis

Junior Research Group: Autophagy in Cancer

ZMB Research Program: Oncology

Prof. Dr.Gunther Wennemuth

Director of: Institute of Anatomy

ZMB Research Program: Molecular and Chemical Cell Biology

Prof. Dr.Astrid Westendorf

Group: Infection Immunology

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

2024

Bührer, Emanuel; Kicinski, Michal; Mandala, Mario; Pe, Madeline; Long, Georgina V; Atkinson, Victoria; Blank, Christian U; Haydon, Andrew; Dalle, Stéphane; Khattak, Adnan; Carlino, Matteo S; Meshcheryakov, Andrey; Sandhu, Shahneen; Puig, Susana; Schadendorf, Dirk; Jamal, Rahima; Rutkowski, Piotr; van den Eertwegh, Alfonsus J M; Coens, Corneel; Grebennik, Dmitri; Krepler, Clemens; Robert, Caroline; Eggermont, Alexander M M

Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054) : Long-term, health-related quality-of-life results from a double-blind, randomised, controlled, phase 3 trial

In: The Lancet Oncology Vol. 25 (2024) Nr. 9, pp. 1202 - 1212

Online Full Text: dx.doi.org/
Felip, E.; Cho, B.C.; Gutiérrez, V.; Alip, A.; Besse, B.; Lu, S.; Spira, A.I.; Girard, N.; Califano, R.; Gadgeel, S.M.; Yang, J.C.-H.; Yamamoto, S.; Azuma, K.; Kim, Y.J.; Lee, K.-H.; Danchaivijitr, P.; Ferreira, C.G.; Cheng, Y.; Sendur, M.A.N.; Chang, G.-C.; Wang, C.-C.; Prabhash, K.; Shinno, Y.; Stroyakovskiy, D.; Paz-Ares, L.; Rodriguez-Cid, J.R.; Martin, C.; Campelo, M.R.G.; Hayashi, H.; Nguyen, D.; Tomasini, P.; Gottfried, M.; Dooms, C.; Passaro, A.; Schuler, Martin; Gelatti, A.C.Z.; Owen, S.; Perdrizet, K.; Ou, S.-H.I.; Curtin, J.C.; Zhang, J.; Gormley, M.; Sun, T.; Panchal, A.; Ennis, M.; Fennema, E.; Daksh, M.; Sethi, S.; Bauml, J.M.; Lee, S.-H.

Amivantamab plus lazertinib versus osimertinib in first-line EGFR-mutant advanced non-small-cell lung cancer with biomarkers of high-risk disease : a secondary analysis from MARIPOSA

In: Annals of Oncology Vol. 35 (2024) Nr. 9, pp. 805 - 816

Online Full Text: dx.doi.org/ (Open Access)
Massoni-Badosa, Ramon; Aguilar-Fernández, Sergio; Nieto, Juan C.; Soler-Vila, Paula; Elosua-Bayes, Marc; Marchese, Domenica; Kulis, Marta; Vilas-Zornoza, Amaia; Bühler, Marco Matteo; Rashmi, Sonal; Alsinet, Clara; Caratù, Ginevra; Moutinho, Catia; Ruiz, Sara; Lorden, Patricia; Lunazzi, Giulia; Colomer, Dolors; Frigola, Gerard; Blevins, Will; Romero-Rivero, Lucia; Jiménez-Martínez, Víctor; Vidal, Anna; Mateos-Jaimez, Judith; Maiques-Diaz, Alba; Ovejero, Sara; Moreaux, Jérôme; Palomino, Sara; Gomez-Cabrero, David; Agirre, Xabier; Weniger, Marc A.; King, Hamish W.; Garner, Lucy C.; Marini, Federico; Cervera-Paz, Francisco Javier; Baptista, Peter M.; Vilaseca, Isabel; Rosales, Cecilia; Ruiz-Gaspà, Silvia; Talks, Benjamin; Sidhpura, Keval; Pascual-Reguant, Anna; Hauser, Anja E.; Haniffa, Muzlifah; Prosper, Felipe; Küppers, Ralf; Gut, Ivo Glynne; Campo, Elias; Martin-Subero, José Ignacio; Heyn, Holger

An atlas of cells in the human tonsil

In: Immunity Vol. 57 (2024) Nr. 2, pp. 379 - 399.e18

Online Full Text: dx.doi.org/ (Open Access)
Prosdocimi, Elena; Carpanese, Veronica; Todesca, Luca Matteo; Varanita, Tatiana; Bachmann, Magdalena; Festa, Margherita; Bonesso, Daniele; Perez-Verdaguer, Mireia; Carrer, Andrea; Velle, Angelo; Peruzzo, Roberta; Muccioli, Silvia; Doni, Davide; Leanza, Luigi; Costantini, Paola; Stein, Frank; Rettel, Mandy; Felipe, Antonio; Edwards, Michael J.; Gulbins, Erich; Cendron, Laura; Romualdi, Chiara; Checchetto, Vanessa; Szabo, Ildiko

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway

In: Science Advances Vol. 10 (2024) Nr. 36, eadn9361

Online Full Text: dx.doi.org/ (Open Access)
Anker, Markus S.; Rassaf, Tienush; Zamorano, José L.; Khan, Muhammad Shahzeb; Landmesser, Ulf

Cardiac wasting and cancer

In: European Heart Journal Vol. 45 (2024) Nr. 34, pp. 3135 - 3137

Online Full Text: dx.doi.org/ (Open Access)
Arrieta-Bolaños, Esteban; van der Burg, Lars L. J.; Gedde-Dahl, Tobias; Robin, Marie; Salmenniemi, Urpu; Kröger, Nicolaus; Yakoub-Agha, Ibrahim; Huynh, Anne; Crawley, Charles; Deconinck, Eric; Bulabois, Claude Eric; Forcade, Edouard; Tholouli, Eleni; van der Hem, Joost G. K.; van Balen, Peter; Hoogenboom, Jorinde D.; de Wreede, Liesbeth C.; Malard, Florent; Ruggeri, Annalisa; Fleischhauer, Katharina

Directionality of HLA-DP permissive mismatches improves risk prediction in HCT for acute leukemia and MDS

In: Blood (2024) in press

Online Full Text: dx.doi.org/
Karpinski, Madeleine J; Hüsing, Johannes; Claassen, Kevin; Möller, Lennart; Kajüter, Hiltraud; Oesterling, Florian; Grünwald, Viktor; Umutlu, Lale; Kleesiek, Jens; Telli, Tugce; Merkel-Jens, Anja; Hüsing, Anika; Kesch, Claudia; Herrmann, Ken; Eiber, Matthias; Hoberück, Sebastian; Meyer, Philipp T; Kind, Felix; Rahbar, Kambiz; Schäfers, Michael; Stang, Andreas; Hadaschik, Boris A.; Fendler, Wolfgang P.

Combining PSMA-PET and PROMISE to re-define disease stage and risk in patients with prostate cancer : A multicentre retrospective study

In: The Lancet Oncology Vol. 25 (2024) Nr. 9, pp. 1188 - 1201

Online Full Text: dx.doi.org/ (Open Access)
Dobersalske, Celia; Rauschenbach, Laurèl; Hua, Yichao; Berliner, Christoph; Steinbach, Anita; Grüneboom, Anika; Kokkaliaris, Konstantinos D.; Heiland, Dieter H.; Berger, Pia; Langer, Sarah; Tan, Chin L.; Stenzel, Martin; Landolsi, Somaya; Weber, Flora; Darkwah Oppong, Marvin; Werner, Rudolf A.; Gull, Hanah; Schröder, Thomas; Linsenmann, Thomas; Buck, Andreas K.; Gunzer, Matthias; Stuschke, Martin; Keyvani, Kathy; Forsting, Michael; Glas, Martin; Kipnis, Jonathan; Steindler, Dennis A.; Reinhardt, Hans Christian; Green, Edward W.; Platten, Michael; Tasdogan, Alpaslan; Herrmann, Ken; Rambow, Florian; Cima, Igor; Sure, Ulrich; Scheffler, Björn

Cranioencephalic functional lymphoid units in glioblastoma

In: Nature Medicine (2024) in press

Online Full Text: dx.doi.org/ (Open Access)
Desch, Steffen; Zeymer, Uwe; Akin, Ibrahim; Behnes, Michael; Duerschmied, Daniel; Rassaf, Tienush; Mahabadi, Amir Abbas; Lehmann, Ralf; Eitel, Ingo; Graf, Tobias; Seidler, Tim; Schuster, Andreas; Thevathasan, Tharusan; Skurk, Carsten; Clemmensen, Peter; Hennersdorf, Marcus; Fichtlscherer, Stephan; Voigt, Ingo; Seyfarth, Melchior; John, Stefan; Ewen, Sebastian; Linke, Axel; Tigges, Eike; Nordbeck, Peter; Bruch, Leonhard; Jung, Christian; Franz, Jutta; Lauten, Philipp; Noc, Marko; Fuernau, Georg; Feistritzer, Hans-Josef; Pöss, Janine; Kirchhof, Eva; Ouarrak, Taoufik; Schneider, Steffen; Freund, Anne; Thiele, Holger

Routine extracorporeal life support in infarct-related cardiogenic shock : 1-year results of the ECLS-SHOCK trial

In: European Heart Journal Vol. 45 (2024) Nr. 39, pp. 4200 - 4203

Online Full Text: dx.doi.org/ (Open Access)
Lu, I-Na; Cheung, Phyllis Fung-Yi; Heming, Michael; Thomas, Christian; Giglio, Giovanni; Leo, Markus; Erdemir, Merve; Wirth, Timo; König, Simone; Dambietz, Christine A.; Schroeter, Christina B.; Nelke, Christopher; Siveke, Jens; Ruck, Tobias; Klotz, Luisa; Haider, Carmen; Höftberger, Romana; Kleinschnitz, Christoph; Wiendl, Heinz; Hagenacker, Tim; Meyer zu Horste, Gerd

Cell-mediated cytotoxicity within CSF and brain parenchyma in spinal muscular atrophy unaltered by nusinersen treatment

In: Nature Communications Vol. 15 (2024) Nr. 1, 4120

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Heinrich, Michael C.; Zhang, Xinhua; Jones, Robin L.; George, Suzanne; Serrano, César; Deng, Yanhong; Bauer, Sebastian; Cai, Shirong; Wu, Xin; Zhou, Yongjian; Tao, Kaixiong; Zheng, Zhichao; Zhang, Jun; Cui, Yuehong; Cao, Hui; Wang, Meining; Hu, Jin; Yang, Jason; Li, Jian; Shen, Lin

Clinical Benefit of Avapritinib in KIT-Mutant Gastrointestinal Stromal Tumors : A Post Hoc Analysis of the Phase I NAVIGATOR and Phase I/II CS3007-001 Studies

In: Clinical Cancer Research Vol. 30 (2024) Nr. 4, pp. 719 - 728

Online Full Text: dx.doi.org/
Singh, Simron; Halperin, Daniel; Myrehaug, Sten; Herrmann, Ken; Pavel, Marianne; Kunz, Pamela L; Chasen, Beth; Tafuto, Salvatore; Lastoria, Secondo; Capdevila, Jaume; García-Burillo, Amparo; Oh, Do-Youn; Yoo, Changhoon; Halfdanarson, Thorvardur R; Falk, Stephen; Folitar, Ilya; Zhang, Yufen; Aimone, Paola; de Herder, Wouter W; Ferone, Diego

[¹⁷⁷Lu]Lu-DOTA-TATE plus long-acting octreotide versus high‑dose long-acting octreotide for the treatment of newly diagnosed, advanced grade 2–3, well-differentiated, gastroenteropancreatic neuroendocrine tumours (NETTER-2) : an open-label, randomised, phase 3 study

In: Lancet Vol. 403 (2024) Nr. 10446, pp. 2807 - 2817

Online Full Text: dx.doi.org/
Lüsebrink, Enzo; Binzenhöfer, Leonhard; Hering, Daniel; Villegas Sierra, Laura; Schrage, Benedikt; Scherer, Clemens; Speidl, Walter S.; Uribarri, Aitor; Sabate, Manel; Noc, Marko; Sandoval, Elena; Erglis, Andrejs; Pappalardo, Federico; De Roeck, Frederic; Tavazzi, Guido; Riera, Jordi; Roncon-Albuquerque, Roberto; Meder, Benjamin; Lüdike, Peter; Rassaf, Tienush; Hausleiter, Jörg; Hagl, Christian; Zimmer, Sebastian; Westermann, Dirk; Combes, Alain; Zeymer, Uwe; Massberg, Steffen; Schäfer, Andreas; Orban, Martin; Thiele, Holger

Scrutinizing the Role of Venoarterial Extracorporeal Membrane Oxygenation : Has Clinical Practice Outpaced the Evidence?

In: Circulation Vol. 149 (2024) Nr. 13, pp. 1033 - 1052

Online Full Text: dx.doi.org/
Gelderblom, Hans; Bhadri, Vivek; Stacchiotti, Silvia; Bauer, Sebastian; Wagner, Andrew J; van de Sande, Michiel; Bernthal, Nicholas M; López Pousa, Antonio; Razak, Albiruni Abdul; Italiano, Antoine; Ahmed, Mahbubl; Le Cesne, Axel; Tinoco, Gabriel; Boye, Kjetil; Martín-Broto, Javier; Palmerini, Emanuela; Tafuto, Salvatore; Pratap, Sarah; Powers, Benjamin C; Reichardt, Peter; Casado Herráez, Antonio; Rutkowski, Piotr; Tait, Christopher; Zarins, Fiona; Harrow, Brooke; Sharma, Maitreyi G; Ruiz-Soto, Rodrigo; Sherman, Matthew L; Blay, Jean-Yves; Tap, William D; Loong, Herbert; Brunello, Antonella; Krieg, Andreas; Algulnik, Mark; Riedel, Richard; Okuno, Scott; Loggers, Elizabeth; Alcindor, Thierry; Ferraresi, Virginia; Serrano, César; Randall, R. Lor; Wilky, Breelyn; Ravi, Vinod

Vimseltinib versus placebo for tenosynovial giant cell tumour (MOTION) : a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

In: Lancet Vol. 403 (2024) Nr. 10445, pp. 2709 - 2719

Online Full Text: dx.doi.org/
Tretter, Celina; de Andrade Krätzig, Niklas; Pecoraro, Matteo; Lange, Sebastian; Seifert, Philipp; von Frankenberg, Clara; Untch, Johannes; Zuleger, Gabriela; Wilhelm, Mathias; Zolg, Daniel P.; Dreyer, Florian S.; Bräunlein, Eva; Engleitner, Thomas; Uhrig, Sebastian; Boxberg, Melanie; Steiger, Katja; Slotta-Huspenina, Julia; Ochsenreither, Sebastian; von Bubnoff, Nikolas; Bauer, Sebastian; Boerries, Melanie; Jost, Philipp J.; Schenck, Kristina; Dresing, Iska; Bassermann, Florian; Friess, Helmut; Reim, Daniel; Grützmann, Konrad; Pfütze, Katrin; Klink, Barbara; Schröck, Evelin; Haller, Bernhard; Kuster, Bernhard; Mann, Matthias; Weichert, Wilko; Fröhling, Stefan; Rad, Roland; Hiltensperger, Michael; Krackhardt, Angela M.

Correction to: Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification

In: Nature Communications Vol. 15 (2024) Nr. 1, 2364

Online Full Text: dx.doi.org/ (Open Access)
Teuber, A.; Schulz, T.; Fletcher, B.S.; Gontla, R.; Mühlenberg, Thomas; Zischinsky, M.-L.; Niggenaber, J.; Weisner, J.; Kleinbölting, S.B.; Lategahn, J.; Sievers, S.; Müller, M.P.; Bauer, Sebastian; Rauh, D.

Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA

In: Nature Communications Vol. 15 (2024) Nr. 1, 63

Online Full Text: dx.doi.org/ (Open Access)
Schuler, Martin; Cuppens, Kristof; Plönes, Till; Wiesweg, Marcel; Du Pont, Bert; Hegedus, Balazs; Köster, Johannes; Mairinger, Fabian; Darwiche, Kaid; Paschen, Annette; Maes, Brigitte; Vanbockrijck, Michel; Lähnemann, David; Zhao, Fang; Hautzel, Hubertus; Theegarten, Dirk; Hartemink, Koen; Reis, Henning; Baas, Paul; Schramm, Alexander; Aigner, Clemens

Neoadjuvant nivolumab with or without relatlimab in resectable non-small-cell lung cancer : A randomized phase 2 trial

In: Nature Medicine Vol. 30 (2024) Nr. 6, pp. 1602 - 1611

Online Full Text: dx.doi.org/ (Open Access)
George, Julie; Maas, Lukas; Abedpour, Nima; Cartolano, Maria; Kaiser, Laura; Fischer, Rieke N.; Scheel, Andreas H.; Weber, Jan-Philipp; Hellmich, Martin; Bosco, Graziella; Volz, Caroline; Mueller, Christian; Dahmen, Ilona; John, Felix; Alves, Cleidson Padua; Werr, Lisa; Panse, Jens Peter; Kirschner, Martin; Engel-Riedel, Walburga; Jürgens, Jessica; Stoelben, Erich; Brockmann, Michael; Grau, Stefan; Sebastian, Martin; Stratmann, Jan A.; Kern, Jens; Hummel, Horst-Dieter; Hegedüs, Balazs; Schuler, Martin; Plönes, Till; Aigner, Clemens; Elter, Thomas; Toepelt, Karin; Ko, Yon-Dschun; Kurz, Sylke; Grohé, Christian; Serke, Monika; Höpker, Katja; Hagmeyer, Lars; Doerr, Fabian; Hekmath, Khosro; Strapatsas, Judith; Kambartel, Karl-Otto; Chakupurakal, Geothy; Busch, Annette; Bauernfeind, Franz-Georg; Griesinger, Frank; Luers, Anne; Dirks, Wiebke; Wiewrodt, Rainer; Luecke, Andrea; Rodermann, Ernst; Diel, Andreas; Hagen, Volker; Severin, Kai; Ullrich, Roland T.; Reinhardt, Hans Christian; Quaas, Alexander; Bogus, Magdalena; Courts, Cornelius; Nürnberg, Peter; Becker, Kerstin; Achter, Viktor; Büttner, Reinhard; Wolf, Jürgen; Peifer, Martin; Thomas, Roman K.

Evolutionary trajectories of small cell lung cancer under therapy

In: Nature Vol. 627 (2024) Nr. 8005, pp. 880 - 889

Online Full Text: dx.doi.org/ (Open Access)
Heinrich, Michael C.; Jones, Robin L.; George, Suzanne; Gelderblom, Hans; Schöffski, Patrick; von Mehren, Margaret; Zalcberg, John R.; Kang, Yoon-Koo; Razak, Albiruni Abdul; Trent, Jonathan; Attia, Steven; Le Cesne, Axel; Siontis, Brittany L.; Goldstein, David; Boye, Kjetil; Sanchez, Cesar; Steeghs, Neeltje; Rutkowski, Piotr; Druta, Mihaela; Serrano, César; Somaiah, Neeta; Chi, Ping; Reichmann, William; Sprott, Kam; Achour, Haroun; Sherman, Matthew L.; Ruiz-Soto, Rodrigo; Blay, Jean-Yves; Bauer, Sebastian

Ripretinib versus sunitinib in gastrointestinal stromal tumor : ctDNA biomarker analysis of the phase 3 INTRIGUE trial

In: Nature Medicine Vol. 30 (2024) Nr. 2, pp. 498 - 506

Online Full Text: dx.doi.org/ (Open Access)
Knittel, Gero; Reinhardt, Hans Christian

XPO1-Mediated mRNA Export of Genome Maintenance Regulators Drives Chemotherapy Resistance in Aggressive Lymphoma

In: Cancer Research Vol. 84 (2024) Nr. 1, pp. 3 - 5

Online Full Text: dx.doi.org/
Pozniak, Joanna; Pedri, Dennis; Landeloos, Ewout; Van Herck, Yannick; Antoranz, Asier; Vanwynsberghe, Lukas; Nowosad, Ada; Roda, Niccolò; Makhzami, Samira; Bervoets, Greet; Maciel, Lucas Ferreira; Pulido-Vicuña, Carlos Ariel; Pollaris, Lotte; Seurinck, Ruth; Zhao, Fang; Flem-Karlsen, Karine; Damsky, William; Chen, Limin; Karagianni, Despoina; Cinque, Sonia; Kint, Sam; Vandereyken, Katy; Rombaut, Benjamin; Voet, Thierry; Vernaillen, Frank; Annaert, Wim; Lambrechts, Diether; Boecxstaens, Veerle; Saeys, Yvan; van den Oord, Joost; Bosisio, Francesca; Karras, Panagiotis; Shain, A. Hunter; Bosenberg, Marcus; Leucci, Eleonora; Paschen, Annette; Rambow, Florian; Bechter, Oliver; Marine, Jean-Christophe

A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma

In: Cell Vol. 187 (2024) Nr. 1, pp. 166 - 183.e25

Online Full Text: dx.doi.org/ (Open Access)
Heger, Jan-Michel; Mattlener, Julia; Schneider, Jessica; Gödel, Philipp; Sieg, Noëlle; Ullrich, Fabian; Lewis, Richard; Bucaciuc-Mracica, Teodora; Schwarz, Roland F.; Rueß, Daniel; Ruge, Maximilian I.; Montesinos-Rongen, Manuel; Deckert, Martina; Blau, Tobias; Kutsch, Nadine; Balke-Want, Hyatt; Weiss, Jonathan; Becker, Kerstin; Reinhardt, H. Christian; Hallek, Michael; Borchmann, Peter; von Tresckow, Bastian; Borchmann, Sven

Entirely noninvasive outcome prediction in central nervous system lymphomas using circulating tumor DNA

In: Blood Vol. 143 (2024) Nr. 6, pp. 522 - 534

Online Full Text: dx.doi.org/
Käver, Larissa; Hinney, Anke; Rajcsanyi, Luisa Sophie; Maier, Hannah Benedictine; Frieling, Helge; Steiger, Howard; Voelz, Clara; Beyer, Cordian; Trinh, Stefanie; Seitz, Jochen

Epigenetic alterations in patients with anorexia nervosa : A systematic review

In: Molecular Psychiatry (2024) in press

Online Full Text: dx.doi.org/ (Open Access)
Roos, Andreas; Schmitt, Linda-Isabell; Hansmann, Christina; Hezel, Stefanie; Salmanian, Schahin; Hentschel, Andreas; Meyer, Nancy; Marina, Adela Della; Kölbel, Heike; Kleinschnitz, Christoph; Schara-Schmidt, Ulrike; Leo, Markus; Hagenacker, Tim

Alteration of LARGE1 abundance in patients and a mouse model of 5q-associated spinal muscular atrophy

In: Acta Neuropathologica Vol. 147 (2024) Nr. 1, 53

Online Full Text: dx.doi.org/ (Open Access)
Long, Georgina V.; Hauschild, Axel; Santinami, Mario; Kirkwood, John M.; Atkinson, Victoria; Mandala, Mario; Merelli, Barbara; Sileni, Vanna Chiarion; Nyakas, Marta; Haydon, Andrew; Dutriaux, Caroline; Robert, Caroline; Mortier, Laurent; Schachter, Jacob; Schadendorf, Dirk; Lesimple, Thierry; Plummer, Ruth; Larkin, James; Tan, Monique; Adnaik, Sachin Bajirao; Burgess, Paul; Jandoo, Tarveen; Dummer, Reinhard

Final Results for Adjuvant Dabrafenib plus Trametinib in Stage III Melanoma

In: The New England Journal of Medicine (2024) in press

Online Full Text: dx.doi.org/

2023

Weischenfeldt, Joachim; Beroukhim, Rameen; Martincorena, Iñigo; Küppers, Ralf; Schadendorf, Dirk

Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

In: Nature Vol. 578 (2023) Nr. 7793, pp. 102 - 111

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Yakneen, Sergei; M. Waszak, Sebastian; Korbel, Jan O.; Küppers, Ralf; Schadendorf, Dirk

Author Correction : Butler enables rapid cloud-based analysis of thousands of human genomes

In: Nature Biotechnology Vol. 41 (2023) Nr. 4, pp. 577

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Berger, Marc; Brenner, Thorsten; Hinney, Anke; Witzke, Oliver; Konik, Margarethe; The COVID-19 Host Genetics Initiative

A second update on mapping the human genetic architecture of COVID-19

In: Nature Vol. 621 (2023) pp. E7 - E26

Online Full Text: dx.doi.org/ (Open Access)
Weischenfeldt, Joachim; Beroukhim, Rameen; Martincorena, Iñigo; Küppers, Ralf

Author Correction : Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

In: Nature Vol. 614 (2023) pp. E40

Online Full Text: dx.doi.org/ (Open Access)
Gerstung, Moritz; Jolly, Clemency; Leshchiner, Ignaty; Küppers, Ralf; Schadendorf, Dirk

Author Correction : The evolutionary history of 2,658 cancers

In: Nature Vol. 614 (2023) pp. E42

Online Full Text: dx.doi.org/
Calabrese, Claudia; Brazma, Alvis; Brooks, Angela N.; Rätsch, Gunnar; Küppers, Ralf; Schadendorf, Dirk

Author Correction : Genomic basis for RNA alterations in cancer

In: Nature Vol. 614 (2023) Nr. 7948, pp. E37

Online Full Text: dx.doi.org/
Alexandrov, Ludmil B.; Kim, Jaegil; Haradhvala, Nicholas J.; Rozen, Steven G.; Stratton, Michael R.; Küppers, Ralf; Schadendorf, Dirk

Author Correction: : The repertoire of mutational signatures in human cancer

In: Nature Vol. 614 (2023) pp. E41

Online Full Text: dx.doi.org/ (Open Access)
Engelke, Merlin; Schmidt, Cynthia Sabrina; Baldini, Giulia; Parmar, Vicky; Hosch, René; Borys, Katarzyna; Koitka, Sven; Turki, Amin T.; Haubold, Johannes; Horn, Peter; Nensa, Felix

Optimizing platelet transfusion through a personalized deep learning risk assessment system for demand management

In: Blood Vol. 142 (2023) Nr. 26, pp. 2315 - 2326

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Gross, Neil D; Miller, David M; Khushalani, Nikhil I; Divi, Vasu; Ruiz, Emily S; Lipson, Evan J; Meier, Friedegund; Su, Yungpo Bernard; Swiecicki, Paul L; Atlas, Jennifer; Geiger, Jessica L; Hauschild, Axel; Choe, Jennifer H; Hughes, Brett G M; Schadendorf, Dirk; Patel, Vishal A; Homsi, Jade; Taube, Janis M; Lim, Annette M; Ferrarotto, Renata; Yoo, Suk-Young; Mathias, Melissa; Han, Hyunsil; Seebach, Frank; Lowy, Israel; Fury, Matthew G; Rischin, Danny

Neoadjuvant cemiplimab and surgery for stage II–IV cutaneous squamous-cell carcinoma : follow-up and survival outcomes of a single-arm, multicentre, phase 2 study

In: The Lancet Oncology Vol. 24 (2023) Nr. 11, pp. 1196 - 1205

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Rodriguez-Martin, Bernardo; Schadendorf, Dirk; Küppers, Ralf; Campbell, Peter J.

Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

In: Nature Genetics Vol. 55 (2023) Nr. 6, 1080

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Calabrese, Claudia; Brazma, Alvis; Brooks, Angela N.; Rätsch, Gunnar; Küppers, Ralf; Schadendorf, Dirk

Genomic basis for RNA alterations in cancer

In: Nature Vol. 578 (2023) Nr. 7793, pp. 129 - 136

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Fizazi, Karim; Herrmann, Ken; Krause, Bernd J; Rahbar, Kambiz; Chi, Kim N; Morris, Michael J; Sartor, Oliver; Tagawa, Scott T; Kendi, Ayse T; Vogelzang, Nicholas; Calais, Jeremie; Nagarajah, James; Wei, Xiao X; Koshkin, Vadim S; Beauregard, Jean-Mathieu; Chang, Brian; Ghouse, Ray; DeSilvio, Michelle; Messmann, Richard A; de Bono, Johann

Health-related quality of life and pain outcomes with [¹⁷⁷Lu]Lu-PSMA-617 plus standard of care versus standard of care in patients with metastatic castration-resistant prostate cancer (VISION) : a multicentre, open-label, randomised, phase 3 trial

In: The Lancet Oncology Vol. 24 (2023) Nr. 6, pp. 597 - 610

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Weischenfeldt, Joachim; Beroukhim, Rameen; Campbell, Peter J.; Küppers, Ralf; Schadendorf, Dirk

Patterns of somatic structural variation in human cancer genomes

In: Nature Vol. 578 (2023) Nr. 7793, pp. 112 - 121

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Weischenfeldt, Joachim; Beroukhim, Rameen; Campbell, Peter J.; Küppers, Ralf; Schadendorf, Dirk

Author Correction : Patterns of somatic structural variation in human cancer genomes

In: Nature Vol. 614 (2023) Nr. 7948, pp. E38

Online Full Text: dx.doi.org/ (Open Access)
Kocakavuk, Emre; Johnson, Kevin C; Sabedot, Thais S; Reinhardt, Christian; Noushmehr, Houtan; Verhaak, Roel G W

Hemizygous CDKN2A deletion confers worse survival outcomes in IDHmut-noncodel gliomas

In: Neuro-Oncology Vol. 25 (2023) Nr. 9, pp. 1721 - 1723

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Serrano, C.; Bauer, Sebastian; Gómez-Peregrina, D.; Kang, Y.-K.; Jones, R.L.; Rutkowski, P.; Mir, O.; Heinrich, M.C.; Tap, W.D.; Newberry, K.; Grassian, A.; Shi, H.; Bialick, S.; Schöffski, P.; Pantaleo, M.A.; von Mehren, M.; Trent, J.C.; George, S.

Circulating tumor DNA analysis of the phase III VOYAGER trial : KIT mutational landscape and outcomes in patients with advanced gastrointestinal stromal tumor treated with avapritinib or regorafenib

In: Annals of Oncology Vol. 34 (2023) Nr. 7, pp. 615 - 625

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Berning, Philipp; Schmitz, Norbert; Ngoya, Maud; Finel, Hervé; Boumendil, Ariane; Wang, Fengrong; Huang, Xiao-Jun; Hermine, Olivier; Philippe, Laure; Couronné, Lucile; Jaccard, Arnaud; Liu, Daihong; Wu, Depei; Reinhardt, Christian; Chalandon, Yves; Wagner-Drouet, Eva; Kwon, Mi; Zhang, Xi; Carpenter, Ben; Yakoub-Agha, Ibrahim; Wulf, Gerald; López-Jiménez, Javier; Sanz, Jaime; Labussière-Wallet, Hélène; Shimoni, Avichai; Dreger, Peter; Sureda, Anna; Kim, Won Seog; Glass, Bertram

Allogeneic hematopoietic stem cell transplantation for NK/T-cell lymphoma : An international collaborative analysis

In: Leukemia Vol. 37 (2023) Nr. 7, pp. 1511 - 1520

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Ratliff, Miriam; Karimian-Jazi, Kianush; Hoffmann, Dirk C; Rauschenbach, Laurèl; Simon, Matthias; Hai, Ling; Mandelbaum, Henriette; Schubert, Marc C; Kessler, Tobias; Uhlig, Stefanie; Dominguez Azorin, Daniel; Jung, Erik; Osswald, Matthias; Solecki, Gergely; Maros, Máté E; Venkataramani, Varun; Glas, Martin; Etminan, Nima; Scheffler, Björn; Wick, Wolfgang; Winkler, Frank

Individual glioblastoma cells harbor both proliferative and invasive capabilities during tumor progression

In: Neuro-Oncology Vol. 25 (2023) Nr. 12, pp. 2150 - 2162

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Stupia, Simone; Heeke, Christina; Brüggemann, Alicia; Zaremba-Montenari, Anne; Thier, Beatrice; Kretz, Julia; Sucker, Antje; Philip, Manuel; Zelinskyy, Gennadiy; Ferrone, Soldano; Rösch, Alexander; Horn, Susanne; Hadaschik, Eva; Schadendorf, Dirk; Trilling, Mirko; Dittmer, Ulf; Griewank, Klaus; Zhao, Fang; Paschen, Annette

HLA class II loss and JAK1/2 deficiency coevolve in melanoma leading to CD4 T cell and IFNγ cross-resistance

In: Clinical Cancer Research Vol. 29 (2023) Nr. 15, pp. 2894 - 2907

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Rodriguez-Martin, Bernardo; Schadendorf, Dirk; Küppers, Ralf; Campbell, Peter J.

Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

In: Nature Genetics Vol. 52 (2023) Nr. 3, pp. 306 - 319

Online Full Text: dx.doi.org/ (Open Access)
Kebir, Sied; Ullrich, Vivien; Berger, Pia; Dobersalske, Celia; Langer, Sarah; Rauschenbach, Laurèl; Trageser, Daniel; Till, Andreas; Lorbeer, Franziska K.; Wieland, Anja; Wilhelm-Buchstab, Timo; Ahmad, Ashar; Fröhlich, Holger; Cima, Igor; Prasad, Shruthi; Matschke, Johann; Jendrossek, Verena; Remke, Marc; Grüner, Barbara M.; Rösch, Alexander; Siveke, Jens; Herold-Mende, Christel; Blau, Tobias; Keyvani, Kathy; van Landeghem, Frank K H; Pietsch, Torsten; Felsberg, Jörg; Reifenberger, Guido; Weller, Michael; Sure, Ulrich; Brüstle, Oliver; Simon, Matthias; Glas, Martin; Scheffler, Björn

A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma

In: Clinical Cancer Research Vol. 29 (2023) Nr. 2, pp. 488 - 500

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Antuamwine, Benedict Boateng; Bosnjakovic, Rebeka; Hofmann-Vega, Francisca; Wang, Xi; Theodosiou, Theodosios; Iliopoulos, Ioannis; Brandau, Sven

N1 versus N2 and PMN-MDSC : A critical appraisal of current concepts on tumor-associated neutrophils and new directions for human oncology

In: Immunological Reviews Vol. 314 (2023) Nr. 1, pp. 250 - 279

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Karreman, Matthia A.; Bauer, Alexander T.; Solecki, Gergely; Berghoff, Anna S.; Mayer, Chanté D; Frey, Katharina; Hebach, Nils; Feinauer, Manuel J.; Schieber, Nicole L.; Tehranian, Cedric; Mercier, Luc; Singhal, Mahak; Venkataramani, Varun; Schubert, Marc C.; Hinze, Daniel; Hölzel, Michael; Helfrich, Iris; Schadendorf, Dirk; Schneider, Stefan W.; Westphal, Dana; Augustin, Hellmut G.; Goetz, Jacky G.; Schwab, Yannick; Wick, Wolfgang; Winkler, Frank

Active Remodeling of Capillary Endothelium via Cancer Cell-Derived MMP9 Promotes Metastatic Brain Colonization

In: Cancer Research Vol. 83 (2023) Nr. 8, pp. 1299 - 1314

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Yuan, Yuan; Küppers, Ralf; Schadendorf, Dirk; Park, Keunchil; Campbell, Peter J.; Liang, Han

Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers

In: Nature Genetics Vol. 55 (2023) Nr. 6, pp. 1078

Online Full Text: dx.doi.org/ (Open Access)
Alexandrov, Ludmil B.; Kim, Jaegil; Haradhvala, Nicholas J.; Rozen, Steven G.; Stratton, Michael R.; Küppers, Ralf; Schadendorf, Dirk

The repertoire of mutational signatures in human cancer

In: Nature Vol. 578 (2023) Nr. 7793, pp. 94 - 101

Online Full Text: dx.doi.org/ (Open Access)
Becker, Jürgen; Ugurel, Selma; Leiter, Ulrike; Meier, Friedegund; Gutzmer, Ralf; Haferkamp, Sebastian; Zimmer, Lisa; Livingstone, Elisabeth; Eigentler, Thomas K; Hauschild, Axel; Kiecker, Felix; Hassel, Jessica C; Mohr, Peter; Fluck, Michael; Thomas, Ioannis; Garzarolli, Marlene; Grimmelmann, Imke; Drexler, Konstantin; Spillner, Alexandra N; Eckhardt, Sebastian; Schadendorf, Dirk; van Akkoi, Alexander; van Houdt, Winan; Wilhelm, Tabea; Farmer, Kimberly; Ulrich, Claas; Gambichler, Thilo; Bluhm, Leonie; Schinagl, Heidemarie; Kellner, Ivonne; Herbst, Rudolf; Meiß, Frank; Rafei-Shamsabadi, David; Sell, Sabine; Kaatz, Martin; Wulfken, Lena; Hartmann, Martin; Kähler, Katharina; Ziemer, Mirjana; Simon, Jan; Terheyden, Patrick; Thaci, Diamant; Loquai, Carmen; Mitzel-Rink, Heidrun; Grabbe, Stephan; Stege, Henner; Gaiser, Maria; Utikal, Jochen; Berking, Carola; Heinzerling, Lucie; Schlaak, Max; Tomsitz, Dirk; Dyballa, Jörg; Magnolo, Nina; Weishaupt, Carsten; Berneburg, Mark; Garbe, Claus; Flatz, Lukas; Gesierich, Anja; Schilling, Bastian

Adjuvant immunotherapy with nivolumab versus observation in completely resected Merkel cell carcinoma (ADMEC-O) : disease-free survival results from a randomised, open-label, phase 2 trial

In: Lancet Vol. 402 (2023) Nr. 10404, pp. 798 - 808

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Akdemir, Kadir C.; Küppers, Ralf; Schadendorf, Dirk; Futreal, P. Andrew

Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

In: Nature Genetics Vol. 55 (2023) Nr. 6, pp. 1079

Online Full Text: dx.doi.org/ (Open Access)
Cortés-Ciriano, Isidro; Küppers, Ralf; Schadendorf, Dirk; Park, Peter J.

Author Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

In: Nature Genetics Vol. 55 (2023) Nr. 6, 1076

Online Full Text: dx.doi.org/ (Open Access)
Ho, Patricia; Melms, Johannes C.; Rogava, Meri; Frangieh, Chris J.; Poźniak, Joanna; Shah, Shivem B.; Walsh, Zachary; Kyrysyuk, Oleksandr; Amin, Amit Dipak; Caprio, Lindsay; Fullerton, Benjamin T.; Soni, Rajesh Kumar; Ager, Casey R.; Biermann, Jana; Wang, Yiping; Khosravi-Maharlooei, Mohsen; Zanetti, Giorgia; Mu, Michael; Fatima, Hijab; Moore, Emily K.; Vasan, Neil; Bakhoum, Samuel F.; Reiner, Steven L.; Bernatchez, Chantale; Sykes, Megan; Mace, Emily M.; Wucherpfennig, Kai W.; Schadendorf, Dirk; Bechter, Oliver; Shah, Parin; Schwartz, Gary K.; Marine, Jean-Christophe; Izar, Benjamin

The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity

In: Cancer Cell Vol. 41 (2023) Nr. 7, pp. 1207 - 1221.e12

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Catton, Erin A.; Bonsor, Daniel A.; Herrera, Carolina; Stålhammar-Carlemalm, Margaretha; Lyndin, Mykola; Turner, Claire E.; Soden, Jo; van Strijp, Jos A G; Singer, Bernhard B.; van Sorge, Nina M.; Lindahl, Gunnar; McCarthy, Alex J.

Author Correction: Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesis

In: Nature Communications Vol. 14 (2023) Nr. 1, pp. 2675

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Illert, A.L.; Stenzinger, A.; Bitzer, M.; Horak, P.; Gaidzik, V.I.; Möller, Y.; Beha, J.; Öner, Ö.; Schmitt, F.; Laßmann, S.; Ossowski, S.; Schaaf, C.P.; Hallek, M.; Brümmendorf, T.H.; Albers, P.; Fehm, T.; Brossart, P.; Glimm, H.; Schadendorf, Dirk; Bleckmann, A.; Brandts, C.H.; Esposito, I.; Mack, E.; Peters, C.; Bokemeyer, C.; Fröhling, S.; Kindler, T.; Algül, H.; Heinemann, V.; Döhner, H.; Bargou, R.; Ellenrieder, V.; Hillemanns, P.; Lordick, F.; Hochhaus, A.; Beckmann, M.W.; Pukrop, T.; Trepel, M.; Sundmacher, L.; Wesselmann, S.; Nettekoven, G.; Kohlhuber, F.; Heinze, O.; Budczies, J.; Werner, M.; Nikolaou, K.; Beer, A.J.; Tabatabai, G.; Weichert, W.; Keilholz, U.; Boerries, M.; Kohlbacher, O.; Duyster, J.; Thimme, R.; Seufferlein, T.; Schirmacher, P.; Malek, N.P.

The German Network for Personalized Medicine to enhance patient care and translational research

In: Nature Medicine Vol. 29 (2023) Nr. 6, pp. 1298 - 1301

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Erice, Oihane; Narayanan, Shruthi; Feliu, Iker; Entrialgo-Cadierno, Rodrigo; Malinova, Antonia; Vicentini, Caterina; Guruceaga, Elizabeth; Delfino, Pietro; Trajkovic-Arsic, Marija; Moreno, Haritz; Valencia, Karmele; Blanco, Ester; Macaya, Irati; Öhlund, Daniel; Khatri, Purvesh; Lecanda, Fernando; Scarpa, Aldo; Siveke, Jens T.; Corbo, Vincenzo; Ponz-Sarvise, Mariano; Vicent, Silve

LAMC2 Regulates Key Transcriptional and Targetable Effectors to Support Pancreatic Cancer Growth

In: Clinical Cancer Research Vol. 29 (2023) Nr. 6, pp. 1137 - 1154

Online Full Text: dx.doi.org/
Zapatka, Marc; Küppers, Ralf; Schadendorf, Dirk; Lichter, Peter

The landscape of viral associations in human cancers

In: Nature Genetics (2023) Nr. 52, pp. 320 - 330

Online Full Text: dx.doi.org/ (Open Access)
Strickler, John H.; Satake, Hironaga; George, Thomas J.; Yaeger, Rona; Hollebecque, Antoine; Garrido-Laguna, Ignacio; Schuler, Martin; Burns, Timothy F.; Coveler, Andrew L.; Falchook, Gerald S.; Vincent, Mark; Sunakawa, Yu; Dahan, Laetitia; Bajor, David; Rha, Sun-Young; Lemech, Charlotte; Juric, Dejan; Rehn, Marko; Ngarmchamnanrith, Gataree; Jafarinasabian, Pegah; Tran, Qui; Hong, David S.

Sotorasib in KRAS p.G12C-Mutated Advanced Pancreatic Cancer

In: The New England Journal of Medicine Vol. 388 (2023) Nr. 1, pp. 33 - 43

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Küppers, Ralf; Schadendorf, Dirk; ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, et.al.

Author Correction: Pan-cancer analysis of whole genomes

In: Nature Vol. 614 (2023) Nr. 7948, pp. E39

Online Full Text: dx.doi.org/ (Open Access)
Cibir, Zülal; Hassel, Jacqueline; Sonneck, Justin; Kowitz, Lennart; Beer, Alexander; Kraus, Andreas; Hallekamp, Gabriel; Rosenkranz, Martin; Raffelberg, Pascal; Olfen, Sven; Smilowski, Kamil; Burkard, Roman; Helfrich, Iris; Tuz, Ali Ata; Singh, Vikramjeet; Ghosh, Susmita; Sickmann, Albert; Klebl, Anne-Kathrin; Eickhoff, Jan Eike; Klebl, Bert; Seidl, Karsten; Chen, Jianxu; Grabmaier, Anton; Viga, Reinhard; Gunzer, Matthias

ComplexEye : a multi-lens array microscope for high-throughput embedded immune cell migration analysis

In: Nature Communications Vol. 14 (2023) Nr. 1, 8103

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Cortés-Ciriano, Isidro; Küppers, Ralf; Schadendorf, Dirk; Park, Peter J.

Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

In: Nature Genetics Vol. 52 (2023) pp. 331 - 341

Online Full Text: dx.doi.org/ (Open Access)
Sperber, Hannah S.; Raymond, Kyle A.; Bouzidi, Mohamed S.; Ma, Tongcui; Valdebenito, Silvana; Eugenin, Eliseo A.; Roan, Nadia R.; Deeks, Steven G.; Winning, Sandra; Fandrey, Joachim; Schwarzer, Roland; Pillai, Satish K.

The hypoxia-regulated ectonucleotidase CD73 is a host determinant of HIV latency

In: Cell Reports Vol. 42 (2023) Nr. 11, 113285

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Bayraktar, Evren; Graf, Theresa; Ayuk, Francis A.; Beutel, Gernot; Penack, Olaf; Luft, Thomas; Brueder, Nicole; Castellani, Gastone; Reinhardt, H. Christian; Kröger, Nicolaus; Beelen, Dietrich W.; Turki, Amin T.

Data-driven grading of acute graft-versus-host disease

In: Nature Communications Vol. 14 (2023) Nr. 1, 7799

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Akdemir, Kadir C.; Küppers, Ralf; Schadendorf, Dirk; Futreal, P. Andrew

Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

In: Nature Genetics Vol. 52 (2023) Nr. 3, pp. 294 - 305

Online Full Text: dx.doi.org/ (Open Access)
Yuan, Yuan; Küppers, Ralf; Schadendorf, Dirk; Park, Keunchil; Campbell, Peter J.; Liang, Han

Comprehensive molecular characterization of mitochondrial genomes in human cancers

In: Nature Genetics Vol. 52 (2023) pp. 342 - 352

Online Full Text: dx.doi.org/ (Open Access)
Zapatka, Marc; Schadendorf, Dirk; Lichter, Peter

Author Correction: The landscape of viral associations in human cancers

In: Nature Genetics Vol. 55 (2023) Nr. 6, pp. 1077

Online Full Text: dx.doi.org/ (Open Access)
Schleussner, Nikolai; Cauchy, Pierre; Franke, Vedran; Giefing, Maciej; Fornes, Oriol; Vankadari, Naveen; Assi, Salam A.; Costanza, Mariantonia; Weniger, Marc A.; Akalin, Altuna; Anagnostopoulos, Ioannis; Bukur, Thomas; Casarotto, Marco G.; Damm, Frederik; Daumke, Oliver; Edginton-White, Benjamin; Gebhardt, J. Christof M.; Grau, Michael; Grunwald, Stephan; Hansmann, Martin-Leo; Hartmann, Sylvia; Huber, Lionel; Kärgel, Eva; Lusatis, Simone; Noerenberg, Daniel; Obier, Nadine; Pannicke, Ulrich; Fischer, Anja; Reisser, Anja; Rosenwald, Andreas; Schwarz, Klaus; Sundararaj, Srinivasan; Weilemann, Andre; Winkler, Wiebke; Xu, Wendan; Lenz, Georg; Rajewsky, Klaus; Wasserman, Wyeth W.; Cockerill, Peter N.; Scheidereit, Claus; Siebert, Reiner; Küppers, Ralf; Grosschedl, Rudolf; Janz, Martin; Bonifer, Constanze; Mathas, Stephan

Transcriptional reprogramming by mutated IRF4 in lymphoma

In: Nature Communications Vol. 14 (2023) Nr. 1, 6947

Online Full Text: dx.doi.org/ (Open Access)
Cameron, Donald P.; Grosser, Jan; Ladigan, Swetlana; Kuzin, Vladislav; Iliopoulou, Evanthia; Wiegard, Anika; Benredjem, Hajar; Jackson, Kathryn; Liffers, Sven T.; Lueong, Smiths; Cheung, Phyllis F.; Vangala, Deepak; Pohl, Michael; Viebahn, Richard; Teschendorf, Christian; Wolters, Heiner; Usta, Selami; Geng, Keyi; Kutter, Claudia; Arsenian-Henriksson, Marie; Siveke, Jens; Tannapfel, Andrea; Schmiegel, Wolff; Hahn, Stephan A.; Baranello, Laura

Coinhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills pancreatic cancer via readthrough transcription

In: Science Advances Vol. 9 (2023) Nr. 41, eadg5109

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Pant, Shubham; Schuler, Martin; Iyer, Gopa; Witt, Olaf; Doi, Toshihiko; Qin, Shukui; Tabernero, Josep; Reardon, David A.; Massard, Christophe; Minchom, Anna; Lugowska, Iwona; Carranza, Omar; Arnold, Dirk; Gutierrez, Martin; Winter, Helen; Stuyckens, Kim; Crow, Lauren; Najmi, Saltanat; Hammond, Constance; Thomas, Shibu; Santiago-Walker, Ademi; Triantos, Spyros; Sweiti, Hussein; Loriot, Yohann; Greco, Martin Alberto; Coward, Jim; Joshua, Anthony; Karapetis, Christos; Hart, Christopher; Zhang, Alison; Prenen, Hans; Goeminne, Jean-Charles; Machiels, Jean-Pascal; Rottey, Sylvie; Corassa, Marcelo; Molin, Graziela Zibetti Dal; Tiscoski, Katsuki; Jardim, Denis Leonardo Fontes; Mak, Milena; Fu, Wei; Yao, Herui; Huang, Jing; Jiang, Haiping; Chen, Baoshi; Yan, Dong; Yang, Yu; Le Tourneau, Christophe; Penel, Nicolas; Salas, Sébastien; Blay, Jean-Yves; Brachet, Pierre-Emmanuel; Durando, Xavier; Emambux, Sheik; Ravaud, Alain; Folprecht, Gunnar; Ahrens, Marit; Golf, Alexander; Haag, Georg Martin; Lordick, Florian; Desuki, Alexander; Cazzaniga, Marina; Ciardiello, Fortunato; Milella, Michele; Koyama, Takafumi; Hirooka, Yoshiki; Okamoto, Wataru; Aogi, Kenjiro; Kuboki, Yasutoshi; Lee, Jungyun; Kim, Sung-Bae; Ahn, Myung-Ju; Chang, Jong Hee; Kim, Yong-Man; Nam, Do-Hyun; Park, Jae-Sung; Paz-Ares, Luis; Moreno, Victor; Cervantes, Andres; Calvo, Mariona; Falcon, Alejandro; Gonzalez, Antonio; Martinez Bueno, Alejandro; García-Corbacho, Javier; Longo, Federico; Yen, Chia-Jui; Chen, Jen-Shi; Hou, Ming-Feng; Chao, Yee; Rau, Kun-Ming; Chiu, Tai-Jan; Feng, Yin-Hsun; Hsu, Chih-Hung; Huang, Wen-Tsung; Lai, Kuan-Ming; Yeh, Su-peng; Palmer, Daniel; Welsh, Liam; Plummer, Ruth; Iyer, Gopakumar; Bilen, Mehmet; Arrowsmith, Edward; Spigel, David Robert; Zandberg, Dan Paul; Doroshow, Deborah; Lu-Emerson, Christine; Moezi, Mehdi; Paulson, Scott; Ward, Patrick; Chaves, Jorge; Grigg, Claud; Hussein, Atif; Manda, Sudhir; Monticelli, Michael; Qamar, Rubina; Richey, Stephen L; Tamura, David; Wilks, Sharon

Erdafitinib in patients with advanced solid tumours with FGFR alterations (RAGNAR) : An international, single-arm, phase 2 study

In: The Lancet Oncology Vol. 24 (2023) Nr. 8, pp. 925 - 935

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Designing clinical trials based on modern imaging and metastasis-directed treatments in patients with oligometastatic breast cancer : a consensus recommendation from the EORTC Imaging and Breast Cancer Groups

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Decrypting drug actions and protein modifications by dose- and time-resolved proteomics

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Extracorporeal Life Support in Infarct-Related Cardiogenic Shock

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Single-cell analysis of memory B cells from top neutralizers reveals multiple sites of vulnerability within HCMV Trimer and Pentamer

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Germ line variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapy

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KIT and PDGFRA Mutations and Survival of Gastrointestinal Stromal Tumor Patients Treated with Adjuvant Imatinib in a Randomized Trial

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Impact of TP53 on outcome of patients with myelofibrosis undergoing hematopoietic stem cell transplantation

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Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesis

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Impaired humoral immunity to BQ.1.1 in convalescent and vaccinated patients

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Integrative multi-omics reveals two biologically distinct groups of pilocytic astrocytoma

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Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer’s disease

In: Nature Communications Vol. 14 (2023) Nr. 1, 1631

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Interactive enhancer hubs (iHUBs) mediate transcriptional reprogramming and adaptive resistance in pancreatic cancer

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Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer

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Resting natural killer cell homeostasis relies on tryptophan/NAD⁺ metabolism and HIF-1α

In: EMBO Reports (2023) e56156

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Neutrophil Conversion to a Tumor-Killing Phenotype Underpins Effective Microbial Therapy

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Sotorasib versus docetaxel for previously treated non-small-cell lung cancer with KRASG¹²C mutation : a randomised, open-label, phase 3 trial

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Spinal astrocyte dysfunction drives motor neuron loss in late-onset spinal muscular atrophy

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Molecular heterogeneity and commonalities in pancreatic cancer precursors with gastric and intestinal phenotype

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Zoledronic Acid Add-on Therapy for Standard-Risk Ewing Sarcoma Patients in the Ewing 2008R1 Trial

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Neoadjuvant immunotherapy for melanoma is now ready for clinical practice

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Next generation radiotheranostics promoting precision medicine

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Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification

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The transcriptional and regulatory identity of erythropoietin producing cells

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Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses

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2022

Küppers, Ralf; Schadendorf, Dirk; Macintyre, Geoff; PCAWG Consortium

Author Correction : Inferring structural variant cancer cell fraction

In: Nature Communications Vol. 13 (2022) 7568

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Aberrant expansion of spontaneous splenic germinal centers induced by hallmark genetic lesions of aggressive lymphoma

In: Blood Vol. 140 (2022) Nr. 10, pp. 1119 - 1131

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Küppers, Ralf; Schadendorf, Dirk; Feuerbach, Lars; PCAWG Consortium

Author Correction : Genomic footprints of activated telomere maintenance mechanisms in cancer

In: Nature Communications Vol. 13 (2022) 7574

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Arrieta-Bolaños, Esteban; Crivello, Pietro; He, Meilun; Wang, Tao; Gadalla, Shahinaz M.; Paczesny, Sophie; Marsh, Steven G.E.; Lee, Stephanie J.; Spellman, Stephen R.; Bolon, Yung-Tsi; Fleischhauer, Katharina

A core group of structurally similar HLA-DPB1 alleles drives permissiveness after hematopoietic cell transplantation

In: Blood Vol. 140 (2022) Nr. 6, pp. 659 - 663

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Zhao, Yanhe; Wang, Huafeng; Wiesehoefer, Caroline; Shah, Naman B.; Reetz, Evan; Hwang, Jae Yeon; Huang, Xiaofang; Wang, Tse-en; Lishko, Polina V.; Davies, Karen M.; Wennemuth, Gunther; Nicastro, Daniela; Chung, Jean-Ju

3D structure and in situ arrangements of CatSper channel in the sperm flagellum

In: Nature Communications Vol. 13 (2022) Nr. 1, 3439

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Küppers, Ralf; Schadendorf, Dirk; Shuai, Shimin; Stein, Lincoln D.; PCAWG Drivers and Functional Interpretation Working Group; PCAWG Consortium

Author Correction : Combined burden and functional impact tests for cancer driver discovery using DriverPower

In: Nature Communications Vol. 13 (2022) 7571

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Küppers, Ralf; Schadendorf, Dirk; Reimand, Jüri; PCAWG Consortium

Author Correction : Pathway and network analysis of more than 2500 whole cancer genomes

In: Nature Communications Vol. 13 (2022) 7566

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Cellular plasticity upon proton irradiation determines tumor cell radiosensitivity

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Deregulation and epigenetic modification of BCL2-family genes cause resistance to venetoclax in hematologic malignancies

In: Blood Vol. 140 (2022) Nr. 20, pp. 2113 - 2126

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Co-Targeting of MDM2 and CDK4/6 with Siremadlin and Ribociclib for the Treatment of Patients with Well-Differentiated or Dedifferentiated Liposarcoma : Results from a Proof-of-Concept, Phase Ib Study

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Neoadjuvant Cemiplimab for Stage II to IV Cutaneous Squamous-Cell Carcinoma

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C11orf94/Frey is a key regulator for male fertility by controlling Izumo1 complex assembly

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Gold Nanorods Induce Endoplasmic Reticulum Stress and Autocrine Inflammatory Activation in Human Neutrophils

In: ACS Nano Vol. 16 (2022) Nr. 7, pp. 11011 - 11026

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Pan-cancer efficacy of pralsetinib in patients with RET fusion–positive solid tumors from the phase 1/2 ARROW trial

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Persister state-directed transitioning and vulnerability in melanoma

In: Nature Communications Vol. 13 (2022) Nr. 1, 3055

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Preneoplastic somatic mutations including MYD88L²⁶⁵P in lymphoplasmacytic lymphoma

In: Science Advances Vol. 8 (2022) Nr. 3, eabl4644

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Cheung, Phyllis F.; Yang, JiaJin; Fang, Rui; Borgers, Arianna; Krengel, Kirsten; Stoffel, Anne; Althoff, Kristina; Yip, Chi Wai; Siu, Elaine H. L.; Ng, Linda W. C.; Lang, Karl S.; Cham, Lamin B.; Engel, Daniel Robert; Soun, Camille; Cima, Igor; Scheffler, Björn; Striefler, Jana K.; Sinn, Marianne; Bahra, Marcus; Pelzer, Uwe; Oettle, Helmut; Markus, Peter; Smeets, Esther M. M.; Aarntzen, Erik H. J. G.; Savvatakis, Konstantinos; Liffers, Sven-Thorsten; Lueong, Smiths S.; Neander, Christian; Bazarna, Anna; Zhang, Xin; Paschen, Annette; Crawford, Howard C.; Chan, Anthony W. H.; Cheung, Siu Tim; Siveke, Jens

Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression

In: Nature Communications Vol. 13 (2022) Nr. 1, 156

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Mishra, Aniket; Malik, Rainer; Hachiya, Tsuyoshi; Kleinschnitz, Christoph; Dichgans, Martin; Debette, Stephanie; COMPASS Consortium; INVENT Consortium; Dutch Parelsnoer Initiative (PSI) Cerebrovascular Disease Study Group; Estonian Biobank; PRECISE4Q Consortium; FinnGen Consortium; NINDS Stroke Genetics Network (SiGN); MEGASTROKE Consortium; SIREN Consortium; China Kadoorie Biobank Collaborative Group; VA Million Veteran Program; International Stroke Genetics Consortium (ISGC); Biobank Japan; CHARGE Consortium; GIGASTROKE Consortium

Stroke genetics informs drug discovery and risk prediction across ancestries

In: Nature Vol. 611 (2022) Nr. 7934, pp. 115 - 123

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Adjuvant nivolumab plus ipilimumab or nivolumab alone versus placebo in patients with resected stage IV melanoma with no evidence of disease (IMMUNED) : Final results of a randomised, double-blind, phase 2 trial

In: Lancet Vol. 400 (2022) Nr. 10358, pp. 1117 - 1129

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20-Year Steady Increase in Survival of Adult Patients with Relapsed Philadelphia-Positive Acute Lymphoblastic Leukemia Post Allogeneic Hematopoietic Cell Transplantation

In: Clinical Cancer Research Vol. 28 (2022) Nr. 5, pp. 1004 - 1012

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Adjuvant Imatinib in Patients with GIST Harboring Exon 9 KIT Mutations : Results from a Multi-institutional European Retrospective Study

In: Clinical Cancer Research Vol. 28 (2022) Nr. 8, pp. 1672 - 1679

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Küppers, Ralf; Schadendorf, Dirk; Stein, Lincoln D.; PCAWG Consortium

Author Correction : A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

In: Nature Communications Vol. 13 (2022) 7573

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BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment

In: Cancer Research Vol. 82 (2022) Nr. 2, pp. 264 - 277

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Menzies, Alexander M.; da Silva, Ines Pires; Trojaniello, Claudia; Vieu, Elisabeth; Amaria, Rodabe N.; Zimmer, Lisa; Lo, Serigne N.; Burton, Elizabeth M.; Tawbi, Hussein A.; Schadendorf, Dirk; Grob, Jean J.; Ascierto, Paolo A.; Long, Georgina V.; Pires da Silva, Ines

CTLA-4 Blockade Resistance after Relatlimab and Nivolumab

In: The New England Journal of Medicine Vol. 386 (2022) Nr. 17, pp. 1668 - 1669

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Extracellular vesicles and PD-L1 suppress macrophages, inducing therapy resistance in TP53-deficient B-cell malignancies

In: Blood Vol. 139 (2022) Nr. 25, pp. 3617 - 3629

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Mishra, Aniket; Malik, Rainer; Hachiya, Tsuyoshi; Kleinschnitz, Christoph; Dichgans, Martin; Debette, Stephanie

Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries

In: Nature Vol. 612 (2022) Nr. 7938, pp. E7

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Totzeck, Matthias; Michel, Lars; Lin, Yi; Herrmann, Joerg; Rassaf, Tienush

Cardiotoxicity from chimeric antigen receptor-T cell therapy for advanced malignancies

In: European Heart Journal Vol. 43 (2022) Nr. 20, pp. 1928 - 1940

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Hose, Matthias; Günther, Anne; Naser, Eyad; Schumacher, Fabian; Schönberger, Tina; Falkenstein, Julia; Papadamakis, Athanasios; Kleuser, Burkhard; Becker, Katrin Anne; Gulbins, Erich; Haimovitz-Friedman, Adriana; Buer, Jan; Westendorf, Astrid; Hansen, Wiebke

Cell-intrinsic ceramides determine T cell function during melanoma progression

In: eLife Vol. 11 (2022) e83073

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Comprehensive cancer predisposition testing within the prospective MASTER trial identifies hereditary cancer patients and supports treatment decisions for rare cancers

In: Annals of Oncology Vol. 33 (2022) Nr. 11, pp. 1186 - 1199

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Enhancing Radioiodine Incorporation into Radioiodine-Refractory Thyroid Cancer with MAPK Inhibition (ERRITI) : A Single-Center Prospective Two-Arm Study

In: Clinical Cancer Research Vol. 28 (2022) Nr. 19, pp. 4194 - 4202

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Krebs, Matthew G.; Malapelle, Umberto; André, Fabrice; Paz-Ares, Luis; Schuler, Martin; Thomas, David M.; Vainer, Gilad; Yoshino, Takayuki; Rolfo, Christian

Practical Considerations for the Use of Circulating Tumor DNA in the Treatment of Patients With Cancer

In: JAMA Oncology Vol. 8 (2022) Nr. 12, pp. 1830 - 1839

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Interim FDG-PET analysis to identify patients with aggressive non-Hodgkin lymphoma who benefit from treatment intensification : A post-hoc analysis of the PETAL trial

In: Leukemia Vol. 36 (2022) Nr. 12, pp. 2845 - 2852

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Stejerean-Todoran, Ioana; Zimmermann, Katharina; Gibhardt, Christine S; Vultur, Adina; Ickes, Christian; Shannan, Batool; Bonilla del Rio, Zuriñe; Wölling, Anna; Cappello, Sabrina; Sung, Hsu-Min; Shumanska, Magdalena; Zhang, Xin; Nanadikar, Maithily; Latif, Muhammad U; Wittek, Anna; Lange, Felix; Waters, Andrea; Brafford, Patricia; Wilting, Jörg; Urlaub, Henning; Katschinski, Dörthe M; Rehling, Peter; Lenz, Christof; Jakobs, Stefan; Ellenrieder, Volker; Rösch, Alexander; Schön, Michael P; Herlyn, Meenhard; Stanisz, Hedwig; Bogeski, Ivan

MCU controls melanoma progression through a redox-controlled phenotype switch

In: EMBO Reports Vol. 23 (2022) Nr. 11, e54746

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Fleischhauer, Katharina

Haplo-PtCy : Adjusting the HLA barrier

In: Blood Vol. 139 (2022) Nr. 10, pp. 1431 - 1433

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Zeng, Ni; Capelle, Christophe M.; Baron, Alexandre; Kobayashi, Takumi; Cire, Severine; Tslaf, Vera; Leonard, Cathy; Coowar, Djalil; Koseki, Haruhiko; Westendorf, Astrid; Buer, Jan; Brenner, Dirk; Krüger, Rejko; Balling, Rudi; Ollert, Markus; Hefeng, Feng Q.

DJ-1 depletion prevents immunoaging in T-cell compartments

In: EMBO Reports Vol. 23 (2022) Nr. 3, e53302

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Leypoldt, Lisa B.; Besemer, Britta; Asemissen, Anne Marie; Hänel, Mathias; Blau, Igor Wolfgang; Görner, Martin; Ko, Yon-Dschun; Reinhardt, Christian; Staib, Peter; Mann, Christoph; Lutz, Raphael; Munder, Markus; Graeven, Ullrich; Peceny, Rudolf; Salwender, Hans; Jauch, Anna; Zago, Manola; Benner, Axel; Tichy, Diana; Bokemeyer, Carsten; Goldschmidt, Hartmut; Weisel, Katja C.

Isatuximab, carfilzomib, lenalidomide, and dexamethasone (Isa-KRd) in front-line treatment of high-risk multiple myeloma : Interim analysis of the GMMG-CONCEPT trial

In: Leukemia Vol. 36 (2022) Nr. 3, pp. 885 - 888

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Long, Georgina V; Luke, Jason J; Khattak, Muhammad A; de la Cruz Merino, Luis; Del Vecchio, Michele; Rutkowski, Piotr; Spagnolo, Francesco; Mackiewicz, Jacek; Chiarion-Sileni, Vanna; Kirkwood, John M; Robert, Caroline; Grob, Jean-Jacques; de Galitiis, Federica; Schadendorf, Dirk; Carlino, Matteo S; Mohr, Peter; Dummer, Reinhard; Gershenwald, Jeffrey E; Yoon, Charles H; Wu, Xi Lawrence; Fukunaga-Kalabis, Mizuho; Krepler, Clemens; Eggermont, Alexander M M; Ascierto, Paolo A

Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma (KEYNOTE-716) : distant metastasis-free survival results of a multicentre, double-blind, randomised, phase 3 trial

In: The Lancet Oncology Vol. 23 (2022) Nr. 11, pp. 1378 - 1388

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Rohlfing, Anne-Katrin; Kolb, Kyra; Sigle, Manuel; Ziegler, Melanie; Bild, Alexander; Münzer, Patrick; Sudmann, Jessica; Dicenta, Valerie; Harm, Tobias; Manke, Mailin-Christin; Geue, Sascha; Kremser, Marcel; Chatterjee, Madhumita; Liang, Chunguang; von Eysmondt, Hendrik; Dandekar, Thomas; Heinzmann, David; Günter, Manina; von Ungern-Sternberg, Saskia; Büttcher, Manuela; Castor, Tatsiana; Mencl, Stine; Langhauser, Friederike; Sies, Katharina; Ashour, Diyaa; Beker, Mustafa Caglar; Lämmerhofer, Michael; Autenrieth, Stella E.; Schäffer, Tilman E.; Laufer, Stefan; Szklanna, Paulina; Maguire, Patricia; Heikenwalder, Matthias; Müller, Karin Anne Lydia; Hermann, Dirk M.; Kilic, Ertugrul; Stumm, Ralf; Ramos, Gustavo; Kleinschnitz, Christoph; Borst, Oliver; Langer, Harald F.; Rath, Dominik; Gawaz, Meinrad

ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury

In: Nature Communications Vol. 13 (2022) Nr. 1, 1823

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Küppers, Ralf; Schadendorf, Dirk; Creighton, Chad J.; PCAWG Consortium

Author Correction : High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations

In: Nature Communications Vol. 13 (2022) 7572

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Frede, Annika; Czarnewski, Paulo; Monasterio, Gustavo; Tripathi, Kumar P.; Bejarano, David A.; Ramirez Flores, Ricardo O.; Sorini, Chiara; Larsson, Ludvig; Luo, Xinxin; Geerlings, Laura; Novella-Rausell, Claudio; Zagami, Chiara; Kuiper, Raoul; Morales, Rodrigo A.; Castillo, Francisca; Hunt, Matthew; Mariano, Livia Lacerda; Hu, Yue O.O.; Engblom, Camilla; Lennon-Duménil, Ana-Maria; Mittenzwei, Romy; Westendorf, Astrid; Hövelmeyer, Nadine; Lundeberg, Joakim; Saez-Rodriguez, Julio; Schlitzer, Andreas; Das, Srustidhar; Villablanca, Eduardo J.

B cell expansion hinders the stroma-epithelium regenerative cross talk during mucosal healing

In: Immunity Vol. 55 (2022) Nr. 12, pp. 2336 - 2351.e12

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Küppers, Ralf; Schadendorf, Dirk; Morris, Quaid D.; PCAWG Consortium

Author Correction : Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig

In: Nature Communications Vol. 13 (2022) 7567

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Küppers, Ralf; Schadendorf, Dirk; Reimand, Jüri; PCAWG Drivers and Functional Interpretation Working Group; PCAWG Consortium

Author Correction : Integrative pathway enrichment analysis of multivariate omics data

In: Nature Communications Vol. 13 (2022) 7570

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Küppers, Ralf; Schadendorf, Dirk; Bristow, Robert G.; Boutros, Paul C.; PCAWG Consortium

Author Correction : Divergent mutational processes distinguish hypoxic and normoxic tumours

In: Nature Communications Vol. 13 (2022) 7569

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Pylaeva, Ekaterina; Korschunow, Georg; Spyra, Ilona; Bordbari, Sharareh; Siakaeva, Elena; Ozel, Irem; Domnich, Maksim; Squire, Anthony; Hasenberg, Anja; Thangavelu, Kruthika; Hussain, Timon; Goetz, Moritz; Lang, Karl S.; Gunzer, Matthias; Hansen, Wiebke; Buer, Jan; Bankfalvi, Agnes; Lang, Stephan; Jablonska, Jadwiga

During early stages of cancer, neutrophils initiate anti-tumor immune responses in tumor-draining lymph nodes

In: Cell Reports Vol. 40 (2022) Nr. 7, 111171

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Michel, Lars; Helfrich, Iris; Hendgen-Cotta, Ulrike Barbara; Mincu, Raluca-Ileana; Korste, Sebastian; Mrotzek, Simone Maria; Spomer, Armin; Odersky, Andrea; Rischpler, Christoph; Herrmann, Ken; Umutlu, Lale; Coman, Cristina; Ahrends, Robert; Sickmann, Albert; Löffek, Stefanie; Livingstone, Elisabeth; Ugurel, Selma; Zimmer, Lisa; Gunzer, Matthias; Schadendorf, Dirk; Totzeck, Matthias; Rassaf, Tienush

Targeting early stages of cardiotoxicity from anti-PD1 immune checkpoint inhibitor therapy

In: European Heart Journal Vol. 43 (2022) Nr. 4, pp. 316 - 329

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Wilke, Anne C.; Doebele, Carmen; Zindel, Alena; Lee, Kwang Seok; Rieke, Sara A.; Ceribelli, Michele; Comoglio, Federico; Phelan, James D.; Wang, James Q.; Pikman, Yana; Jahn, Dominique; Häupl, Björn; Schneider, Constanze; Scheich, Sebastian; Tosto, Frances A.; Bohnenberger, Hanibal; Stauder, Philipp; Schnütgen, Frank; Slabicki, Mikolaj; Coulibaly, Zana A.; Wolf, Sebastian; Bojarczuk, Kamil; Chapuy, Björn; Brandts, Christian H.; Stroebel, Philipp; Lewis, Caroline A.; Engelke, Michael; Xu, Xincheng; Kim, Hahn; Dang, Thanh Hung; Schmitz, Roland; Hodson, Daniel J.; Stegmaier, Kimberly; Urlaub, Henning; Serve, Hubert; Schmitt, Clemens A.; Kreuz, Fernando; Knittel, Gero; Rabinowitz, Joshua D.; Reinhardt, Christian; Vander Heiden, Matthew G.; Thomas, Craig; Staudt, Louis M.; Zenz, Thorsten; Oellerich, Thomas

SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma

In: Blood Vol. 139 (2022) Nr. 4, pp. 538 - 553

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Lüdike, Peter; Heusch, Gerd; Rassaf, Tienush

The RUHR Heart Failure Network : Improved heart failure care in a metropolitan area

In: European Heart Journal Vol. 43 (2022) Nr. 45, pp. 4675 - 4676

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Stein, Eytan M.; DeAngelo, Daniel J.; Chromik, Jörg; Chatterjee, Manik; Bauer, Sebastian; Lin, Chia-Chi; Suarez, Cristina; de Vos, Filip; Steeghs, Neeltje; Cassier, Philippe A.; Tai, David; Kiladjian, Jean-Jacques; Yamamoto, Noboru; Mous, Rogier; Esteve, Jordi; Minami, Hironobu; Ferretti, Stephane; Guerreiro, Nelson; Meille, Christophe; Radhakrishnan, Rajkumar; Pereira, Bernard; Mariconti, Luisa; Halilovic, Ensar; Fabre, Claire; Carpio, Cecilia; Cassier, Phillippe A.

Results from a First-in-Human Phase I Study of Siremadlin (HDM201) in Patients with Advanced Wild-Type TP53 Solid Tumors and Acute Leukemia

In: Clinical Cancer Research Vol. 28 (2022) Nr. 5, pp. 870 - 881

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Bartl, Jasmin; Zanini, Marco; Bernardi, Flavia; Forget, Antoine; Blümel, Lena; Talbot, Julie; Picard, Daniel; Qin, Nan; Cancila, Gabriele; Gao, Qingsong; Nath, Soumav; Koumba, Idriss Mahoungou; Wolter, Marietta; Kuonen, François; Langini, Maike; Beez, Thomas; Munoz, Christopher; Pauck, David; Marquardt, Viktoria; Yu, Hua; Souphron, Judith; Korsch, Mascha; Mölders, Christina; Berger, Daniel; Göbbels, Sarah; Meyer, Frauke-Dorothee; Scheffler, Björn; Rotblat, Barak; Diederichs, Sven; Ramaswamy, Vijay; Suzuki, Hiromishi; Oro, Anthony; Stühler, Kai; Stefanski, Anja; Fischer, Ute; Leprivier, Gabriel; Willbold, Dieter; Steger, Gerhard; Buell, Alexander; Kool, Marcel; Lichter, Peter; Pfister, Stefan M.; Northcott, Paul A.; Taylor, Michael D.; Borkhardt, Arndt; Reifenberger, Guido; Ayrault, Olivier; Remke, Marc

The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors

In: Nature Communications Vol. 13 (2022) Nr. 1, 4061

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Grüneboom, Anika; Aust, Oliver; Cibir, Zülal; Weber, Flora; Hermann, Dirk M.; Gunzer, Matthias

Imaging innate immunity*

In: Immunological Reviews Vol. 306 (2022) Nr. 1, pp. 293 - 303

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Tawbi, Hussein A.; Schadendorf, Dirk; Lipson, Evan J.; Ascierto, Paolo A.; Matamala, Luis; Castillo Gutiérrez, Erika; Rutkowski, Piotr; Gogas, Helen J.; Lao, Christopher D.; De Menezes, Juliana Janoski; Dalle, Stéphane; Arance, Ana; Grob, Jean-Jacques; Srivastava, Shivani; Abaskharoun, Mena; Hamilton, Melissa; Keidel, Sarah; Simonsen, Katy L.; Sobiesk, Anne Marie; Li, Bin; Hodi, F. Stephen; Long, Georgina V.

Relatlimab and Nivolumab versus Nivolumab in Untreated Advanced Melanoma

In: The New England Journal of Medicine Vol. 386 (2022) Nr. 1, pp. 24 - 34

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Hoertel, Nicolas; Sánchez-Rico, Marina; Herrera-Morueco, Juan José; de la Muela, Pedro; Gulbins, Erich; Kornhuber, Johannes; Carpinteiro, Alexander; Becker-Flegler, Katrin; Cougoule, Céline; Limosin, Frédéric

Comorbid medical conditions are a key factor to understand the relationship between psychiatric disorders and COVID-19-related mortality : Results from 49,089 COVID-19 inpatients

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Consensus Statement on Mandatory Measurements for Pancreatic Cancer Trials for Patients with Resectable or Borderline Resectable Disease (COMM-PACT-RB) : A Systematic Review and Delphi Consensus Statement

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Gastrointestinal stromal tumours : ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up

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Pembrolizumab versus placebo as adjuvant therapy in completely resected stage IIB or IIC melanoma (KEYNOTE-716) : a randomised, double-blind, phase 3 trial

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The acid ceramidase/ceramide axis controls parasitemia in Plasmodium yoelii-infected mice by regulating erythropoiesis

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Phase Ib/II Trial of Ribociclib in Combination with Binimetinib in Patients with NRAS-mutant Melanoma

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Safety and Efficacy of 90Y-FAPI-46 Radioligand Therapy in Patients with Advanced Sarcoma and Other Cancer Entities

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Treatment outcome of atypical EGFR mutations in the German National Network Genomic Medicine Lung Cancer (nNGM)

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Stroke induces disease-specific myeloid cells in the brain parenchyma and pia

In: Nature Communications Vol. 13 (2022) Nr. 1, 945

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Kornhuber, Johannes; Hoertel, Nicolas; Gulbins, Erich

The acid sphingomyelinase/ceramide system in COVID-19

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The alarmin interleukin-1α triggers secondary degeneration through reactive astrocytes and endothelium after spinal cord injury

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Berger, Marc; Brenner, Thorsten; Hinney, Anke; Witzke, Oliver

Mapping the human genetic architecture of COVID-19

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Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomas

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Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054) : health-related quality-of-life results from a double-blind, randomised, controlled, phase 3 trial

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Bacterial protein domains with a novel Ig-like fold target human CEACAM receptors

In: The EMBO Journal Vol. 40 (2021) Nr. 7, pp. e106103

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Altered mitochondria functionality defines a metastatic cell state in lung cancer and creates an exploitable vulnerability

In: Cancer Research Vol. 81 (2021) Nr. 3, pp. 567 - 579

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Clinical Activity of Ripretinib in Patients with Advanced Gastrointestinal Stromal Tumor Harboring Heterogeneous KIT/PDGFRA Mutations in the Phase III INVICTUS Study

In: Clinical Cancer Research Vol. 27 (2021) Nr. 23, pp. 6333 - 6342

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An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities

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Bone sarcomas : ESMO–EURACAN–GENTURIS–ERN PaedCan Clinical Practice Guideline for diagnosis, treatment and follow-up

In: Annals of Oncology Vol. 32 (2021) Nr. 12, pp. 1520 - 1536

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Cellular model system to dissect the isoform-selectivity of Akt inhibitors

In: Nature Communications Vol. 12 (2021) Nr. 1, 5297

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Wey, Karolin; Schirrmann, Ronja; Diesing, Detlef; Lang, Stephan; Brandau, Sven; Hansen, Stefan; Epple, Matthias

Coating of cochlear implant electrodes with bioactive DNA-loaded calcium phosphate nanoparticles for the local transfection of stimulatory proteins

In: Biomaterials Vol. 276 (2021)

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EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumours

In: Annals of Oncology Vol. 32 (2021) Nr. 11, pp. 1332 - 1347

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Nuclear medicine theranostics comes of age

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Antibody-guided in vivo imaging of Aspergillus fumigatus lung infections during antifungal azole treatment

In: Nature Communications Vol. 12 (2021) Nr. 1, pp. 1707

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Kohlhaas, Vivien; Blakemore, Stuart James; Al-Maarri, Mona; Nickel, Nadine; Pal, Martin; Roth, Andreas; Hövelmeyer, Nadine; Schäfer, Stephan C.; Knittel, Gero; Lohneis, Philipp; Nikolic, Milos; Wiederstein, Janica L.; Franitza, Marek; Georgomonolis, Theodoros; Reinart, Nina; Herling, Marco; Herling, Carmen; Hartmann, Elena M.; Rosenwald, Andreas; Klapper, Wolfram; Büttner, Reinhard; Moia, Riccardo; Rossi, Davide; Boldorini, Renzo; Gaidano, Gianluca; Frenzel, Lukas P.; Reinhardt, Christian; Brüning, Jens C.; Hallek, Michael; Krüger, Marcus; Peifer, Martin; Pallasch, Christian P.; Wunderlich, F. Thomas

Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1

In: Blood Vol. 137 (2021) Nr. 5, pp. 646 - 660

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Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis

In: Cell Reports Vol. 37 (2021) Nr. 8, 110056

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Comprehensive Genomic and Transcriptomic Analysis for Guiding Therapeutic Decisions in Patients with Rare Cancers

In: Cancer Discovery Vol. 11 (2021) Nr. 11, pp. 2780 - 2795

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Deep Learning Predicts HPV Association in Oropharyngeal Squamous Cell Carcinomas and Identifies Patients with a Favorable Prognosis Using Regular H&E Stains

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Leadership challenges defused

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Molecular biology of Hodgkin lymphoma

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Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion

In: Nature Genetics Vol. 53 (2021) Nr. 3, pp. 332 - 341

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Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid

In: Immunity Vol. 54 (2021) Nr. 1, pp. 164

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Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects

In: Molecular Psychiatry Vol. 26 (2021) Nr. 12, pp. 7403 - 7416

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Zhang, Xiang; Schuhmachers, Patrick; Mourão, André; Giansanti, Piero; Murer, Anita; Thumann, Sybille; Kuklik-Roos, Cornelia; Beer, Sophie; Hauck, Stefanie M; Hammerschmidt, Wolfgang; Küppers, Ralf; Kuster, Bernhard; Raab, Monika; Strebhardt, Klaus; Sattler, Michael; Münz, Christian; Kempkes, Bettina

PLK1-dependent phosphorylation restrains EBNA2 activity and lymphomagenesis in EBV-infected mice

In: EMBO Reports (2021) e53007

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Littwitz-Salomon, Elisabeth; Moreira, Diana; Frost, Joe N.; Choi, Chloe; Liou, Kevin T.; Ahern, David K.; O’Shaughnessy, Simon; Wagner, Bernd; Biron, Christine A.; Drakesmith, Hal; Dittmer, Ulf; Finlay, David K.

Metabolic requirements of NK cells during the acute response against retroviral infection

In: Nature Communications Vol. 12 (2021) Nr. 1, 5376

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Diagnostic Accuracy of ⁶⁸Ga-PSMA-11 PET for Pelvic Nodal Metastasis Detection Prior to Radical Prostatectomy and Pelvic Lymph Node Dissection : A Multicenter Prospective Phase 3 Imaging Trial

In: JAMA Oncology Vol. 7 (2021) Nr. 11, pp. 1635 - 1642

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Brägelmann, Johannes; Lorenz, Carina; Borchmann, Sven; Nishii, Kazuya; Wegner, Julia; Meder, Lydia; Ostendorp, Jenny; Ast, David F.; Heimsoeth, Alena; Nakasuka, Takamasa; Hirabae, Atsuko; Okawa, Sachi; Dammert, Marcel A.; Plenker, Dennis; Klein, Sebastian; Lohneis, Philipp; Gu, Jianing; Godfrey, Laura K.; Forster, Jan; Trajkovic-Arsic, Marija; Zillinger, Thomas; Haarmann, Mareike; Quaas, Alexander; Lennartz, Stefanie; Schmiel, Marcel; D’Rozario, Joshua; Thomas, Emily S.; Li, Henry; Schmitt, Clemens A.; George, Julie; Thomas, Roman K.; von Karstedt, Silvia; Hartmann, Gunther; Büttner, Reinhard; Ullrich, Roland T.; Siveke, Jens; Ohashi, Kadoaki; Schlee, Martin; Sos, Martin L.

MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I

In: Nature Communications Vol. 12 (2021) Nr. 1, 5505

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Kolokotronis, Theodoros; Reis, Henning; Kroiss, Matthias

Multiple Hepatic and Pulmonary Tumors Combined with Bilateral Adrenal Masses in a Young Woman with von Hippel–Lindau Disease

In: Gastroenterology Vol. 161 (2021) Nr. 4, pp. e1 - e4

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Sartor, Oliver; de Bono, Johann; Chi, Kim N; Fizazi, Karim; Herrmann, Ken; Rahbar, Kambiz; Tagawa, Scott T.; Nordquist, Luke T.; Vaishampayan, Nitin; El-Haddad, Ghassan; Park, Chandler H.; Beer, Tomasz M.; Armour, Alison; Pérez-Contreras, Wendy J.; DeSilvio, Michelle; Kpamegan, Euloge; Gericke, Germo; Messmann, Richard A.; Morris, Michael J.; Krause, Bernd J.; VISION Investigators

Lutetium-177-PSMA-617 for Metastatic Castration-Resistant Prostate Cancer

In: The New England Journal of Medicine Vol. 385 (2021) pp. 1091 - 1103

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Syeda, Mahrukh M.; Wiggins, Jennifer M.; Corless, Broderick C; Long, Georgina V.; Flaherty, Keith T.; Schadendorf, Dirk; Nathan, Paul D.; Robert, Caroline; Ribas, Antoni; Davies, Michael A.; Grob, Jean Jacques; Gasal, Eduard; Squires, Matthew; Marker, Mahtab; Garrett, James; Brase, Jan C.; Polsky, David

Circulating tumour DNA in patients with advanced melanoma treated with dabrafenib or dabrafenib plus trametinib : A clinical validation study

In: The Lancet Oncology Vol. 22 (2021) Nr. 3, pp. 370 - 380

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Nguyen, Tan-Trieu; Ramsay, Lee Ann; Ahanfeshar-Adams, Mozhdeh; Lajoie, Mathieu; Schadendorf, Dirk; Alain, Tommy; Watson, Ian R.

Mutations in the IFNγ-JAK-STAT pathway causing resistance to immune checkpoint inhibitors in melanoma increase sensitivity to oncolytic virus treatment

In: Clinical Cancer Research Vol. 27 (2021) Nr. 12, pp. 3432 - 3442

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Rankin-Turner, Stephanie; Vader, Pieter; O'Driscoll, Lorraine; Giebel, Bernd; Heaney, Liam M.; Davies, Owen G.

A call for the standardised reporting of factors affecting the exogenous loading of extracellular vesicles with therapeutic cargos

In: Advanced Drug Delivery Reviews Vol. 173 (2021) pp. 479 - 491

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Kienle, Korbinian; Glaser, Katharina M.; Eickhoff, Sarah; Mihlan, Michael; Knöpper, Konrad; Reátegui, Eduardo; Epple, Maximilian W.; Gunzer, Matthias; Baumeister, Ralf; Tarrant, Teresa K.; Germain, Ronald N.; Irimia, Daniel; Kastenmüller, Wolfgang; Lämmermann, Tim

Neutrophils self-limit swarming to contain bacterial growth in vivo

In: Science Vol. 372 (2021) Nr. 6548,

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Abel, Frederik; Giebel, Bernd; Frey, Ulrich H.

Agony of choice : How anesthetics affect the composition and function of extracellular vesicles

In: Advanced Drug Delivery Reviews Vol. 175 (2021) 113813

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Gafita, Andrei; Calais, Jeremie; Grogan, Tristan R.; Hadaschik, Boris; Wang, Hui; Weber, Manuel; Sandhu, Shahneen; Kratochwil, Clemens; Esfandiari, Rouzbeh; Tauber, Robert; Zeldin, Anna; Rathke, Hendrik; Armstrong, Wesley R.; Robertson, Andrew; Thin, Pan; D'Alessandria, Calogero; Rettig, Matthew B.; Delpassand, Ebrahim S.; Haberkorn, Uwe; Elashoff, David; Herrmann, Ken; Czernin, Johannes; Hofman, Michael S.; Fendler, Wolfgang; Eiber, Matthias

Nomograms to predict outcomes after ¹⁷⁷Lu-PSMA therapy in men with metastatic castration-resistant prostate cancer : An international, multicentre, retrospective study

In: The Lancet Oncology Vol. 22 (2021) Nr. 8, pp. 1115 - 1125

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Adamczyk, Alexandra; Pastille, Eva; Kehrmann, Jan; Vu, Vivian P.; Geffers, Robert; Wasmer, Marie-Hélène; Kasper, Stefan; Schuler, Martin; Lange, Christian; Muggli, Beat; Rau, Tilman T.; Klein, Diana; Hansen, Wiebke; Krebs, Philippe; Buer, Jan; Westendorf, Astrid

GPR15 facilitates recruitment of regulatory T cells to promote colorectal cancer

In: Cancer Research Vol. 81 (2021) Nr. 11, pp. 2970 - 2982

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Sobecki, Michal; Krzywinska, Ewelina; Nagarajan, Shunmugam; Audigé, Annette; Huỳnh, Khanh; Zacharjasz, Julian; Debbache, Julien; Kerdiles, Yann; Gotthardt, Dagmar; Takeda, Norihiko; Fandrey, Joachim; Sommer, Lukas; Sexl, Veronika; Stockmann, Christian

NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence

In: Nature Communications Vol. 12 (2021) Nr. 1, 4700

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Brase, Jan C.; Walter, Robert F.H.; Savchenko, Alexander; Gusenleitner, Daniel; Garrett, James; Schimming, Tobias; Varaljai, Renata; Castelletti, Deborah; Kim, Ju; Dakappagari, Naveen; Schultz, Ken; Robert, Caroline; Long, Georgina V.; Nathan, Paul D.; Ribas, Antoni; Flaherty, Keith T.; Karaszewska, Boguslawa; Schachter, Jacob; Sucker, Antje; Schmid, Kurt Werner; Zimmer, Lisa; Livingstone, Elisabeth; Gasal, Eduard; Schadendorf, Dirk; Rösch, Alexander

Role of Tumor-Infiltrating B Cells in Clinical Outcome of Patients with Melanoma Treated With Dabrafenib Plus Trametinib

In: Clinical Cancer Research Vol. 27 (2021) Nr. 16, pp. 4500 - 4510

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Lu, I-Na; Dobersalske, Celia; Rauschenbach, Laurèl; Teuber-Hanselmann, Sarah; Steinbach, Anita; Ullrich, Vivien; Prasad, Shruthi; Blau, Tobias; Kebir, Sied; Siveke, Jens; Becker, Jürgen; Sure, Ulrich; Glas, Martin; Scheffler, Björn; Cima, Igor

Tumor-associated hematopoietic stem and progenitor cells positively linked to glioblastoma progression

In: Nature Communications Vol. 12 (2021) Nr. 1, 3895

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Hübschmann, Daniel; Kleinheinz, Kortine; Wagener, Rabea; Bernhart, Stephan H.; López, Cristina; Toprak, Umut H.; Sungalee, Stephanie; Ishaque, Naveed; Kretzmer, Helene; Kreuz, Markus; Waszak, Sebastian M.; Paramasivam, Nagarajan; Ammerpohl, Ole; Aukema, Sietse M.; Beekman, Renée; Bergmann, Anke K.; Bieg, Matthias; Binder, Hans; Borkhardt, Arndt; Borst, Christoph; Brors, Benedikt; Bruns, Philipp; Carrillo de Santa Pau, Enrique; Claviez, Alexander; Doose, Gero; Haake, Andrea; Karsch, Dennis; Haas, Siegfried; Hansmann, Martin-Leo; Hoell, Jessica I.; Hovestadt, Volker; Huang, Bingding; Hummel, Michael; Jäger-Schmidt, Christina; Kerssemakers, Jules N. A.; Korbel, Jan O.; Kube, Dieter; Lawerenz, Chris; Lenze, Dido; Martens, Joost H. A.; Ott, German; Radlwimmer, Bernhard; Reisinger, Eva; Richter, Julia; Rico, Daniel; Rosenstiel, Philip; Rosenwald, Andreas; Schillhabel, Markus; Stilgenbauer, Stephan; Stadler, Peter F.; Martín-Subero, José I.; Szczepanowski, Monika; Warsow, Gregor; Weniger, Marc; Zapatka, Marc; Valencia, Alfonso; Stunnenberg, Hendrik G.; Lichter, Peter; Möller, Peter; Loeffler, Markus; Eils, Roland; Klapper, Wolfram; Hoffmann, Steve; Trümper, Lorenz; Küppers, Ralf; Schlesner, Matthias; Siebert, Reiner

Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas

In: Leukemia Vol. 35 (2021) pp. 2002 - 2016

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Cappello, Sabrina; Sung, Hsu-Min; Ickes, Christian; Gibhardt, Christine S.; Vultur, Adina; Bhat, Hilal; Hu, Zhongwen; Brafford, Patricia; Denger, Andreas; Stejerean-Todoran, Ioana; Köhn, Rixa-Mareike; Lorenz, Verena; Künzel, Nicolas; Salinas, Gabriela; Stanisz, Hedwig; Legler, Tobias; Rehling, Peter; Schön, Michael P.; Lang, Karl S.; Helms, Volkhard; Herlyn, Meenhard; Hoth, Markus; Kummerow, Carsten; Bogeski, Ivan

Protein Signatures of NK Cell–Mediated Melanoma Killing Predict Response to Immunotherapies

In: Cancer Research Vol. 81 (2021) Nr. 21, pp. 5540 - 5554

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Şahin, Uǧur; Türeci, Özlem; Manikhas, Georgiy Moiseevich; Lordick, Florian; Rusyn, Andrii; Vynnychenko, Ihor A.; Dudov, Asen; Bazin, Igor S.; Bondarenko, Igor; Melichar, Bohuslav; Dhaene, Karl F.L.; Wiechen, Kai; Huber, Claudia; Maurus, Daniel; Arozullah, A.; Park, J.W.; Schuler, Martin; Al-Batran, Salah Eddin

FAST : a randomised phase II study of zolbetuximab (IMAB362) plus EOX versus EOX alone for first-line treatment of advanced CLDN18.2-positive gastric and gastro-oesophageal adenocarcinoma

In: Annals of Oncology Vol. 32 (2021) Nr. 5, pp. 609 - 619

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Staubach, Simon; Bauer, Fabiola Nardi; Tertel, Tobias; Börger, Verena; Stambouli, Oumaima; Salzig, Denise; Giebel, Bernd

Scaled preparation of extracellular vesicles from conditioned media

In: Advanced Drug Delivery Reviews Vol. 177 (2021) 113940

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Iliakis, George E.

New players in the regulation of DNA-PK activity : Survivin joins the crowd

In: Cancer Research Vol. 81 (2021) Nr. 9, pp. 2270 - 2271

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de Semir, David; Bezrookove, Vladimir; Nosrati, Mehdi; Dar, Altaf A.; Miller, James R.; Leong, Stanley P.; Kim, Kevin B.; Liao, Wilson; Soroceanu, Liliana; McAllister, Sean; Debs, Robert J.; Schadendorf, Dirk; Leachman, Sancy A.; Cleaver, James E.; Kashani-Sabet, Mohammed

Nuclear receptor coactivator NCOA3 regulates UV radiation⇓induced DNA damage and melanoma susceptibility

In: Cancer Research Vol. 81 (2021) Nr. 11, pp. 2956 - 2969

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Soft tissue and visceral sarcomas : ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up☆

In: Annals of Oncology Vol. 32 (2021) Nr. 11, 1348-1365

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Subbiah, Vivek; Hu, Mimi I.; Wirth, Lori J.; Schuler, Martin; Mansfield, Aaron S.; Curigliano, Giuseppe; Brose, Marcia S.; Zhu, Viola W.; Leboulleux, Sophie; Bowles, Daniel W.; Baik, Christina S.; Adkins, Douglas; Keam, Bhumsuk; Matos, Ignacio; Garralda, Elena; Gainor, Justin F.; Lopes, Gilberto; Lin, Chia-Chi; Godbert, Yann; Sarker, Debashis; Miller, Stephen G.; Clifford, Corinne; Zhang, Hui; Turner, Christopher D.; Taylor, Matthew H.

Pralsetinib for patients with advanced or metastatic RET-altered thyroid cancer (ARROW) : a multi-cohort, open-label, registrational, phase 1/2 study

In: The Lancet Diabetes and Endocrinology Vol. 9 (2021) Nr. 8, pp. 491 - 501

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Hoertel, Nicolas; Sánchez-Rico, Marina; Cougoule, Céline; Gulbins, Erich; Kornhuber, Johannes; Carpinteiro, Alexander; Becker, Katrin Anne; Reiersen, Angela M.; Lenze, Eric J.; Seftel, David; Lemogne, Cédric; Limosin, Frédéric

Repurposing antidepressants inhibiting the sphingomyelinase acid/ceramide system against COVID-19 : Current evidence and potential mechanisms

In: Molecular Psychiatry Vol. 26 (2021) Nr. 12, pp. 7098 - 7099

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Veach, Darren R.; Storey, Claire M.; Lückerath, Katharina; Braun, Katharina; von Bodman, Christian; Lamminmäki, Urpo; Kalidindi, Teja; Strand, Sven-Erik; Strand, Joanna; Altai, Mohamed; Damoiseaux, Robert; Zanzonico, Pat; Benabdallah, Nadia; Pankov, Dmitry; Scher, Howard I.; Scardino, Peter; Larson, Steven M.; Lilja, Hans; McDevitt, Michael R.; Thorek, Daniel L.J.; Ulmert, David

PSA-Targeted Alpha-, Beta-, and Positron-Emitting Immunotheranostics in Murine Prostate Cancer Models and Nonhuman Primates

In: Clinical Cancer Research Vol. 27 (2021) Nr. 7, pp. 2050 - 2060

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Skoulidis, Ferdinandos; Li, Bob T.; Dy, Grace K.; Price, Timothy J.; Falchook, Gerald S.; Wolf, Jürgen; Italiano, Antoine; Schuler, Martin; Borghaei, Hossein; Barlesi, Fabrice; Kato, Terufumi; Curioni-Fontecedro, Alessandra; Sacher, Adrian; Spira, Alexander; Ramalingam, Suresh S.; Takahashi, Toshiaki; Besse, Benjamin; Anderson, Abraham; Ang, Agnes; Tran, Qui; Mather, Omar; Henary, Haby; Ngarmchamnanrith, Gataree; Friberg, Gregory; Velcheti, Vamsidhar; Govindan, Ramaswamy

Sotorasib for Lung Cancers with KRAS p.G12C Mutation

In: The New England Journal of Medicine Vol. 384 (2021) Nr. 25, pp. 2371 - 2381

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Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054) : distant metastasis-free survival results from a double-blind, randomised, controlled, phase 3 trial

In: The Lancet Oncology Vol. 22 (2021) Nr. 5, pp. 643 - 654

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Anquetil, Typhaine; Solinhac, Romain; Jaffre, Aude; Chicanne, Gaëtan; Viaud, Julien; Darcourt, Jean; Orset, Cyrille; Geuss, Eva; Kleinschnitz, Christoph; Vanhaesebroeck, Bart; Vivien, Denis; Hnia, Karim; Larrue, Vincent; Payrastre, Bernard; Gratacap, Marie‐Pierre

PI3KC2β inactivation stabilizes VE‐cadherin junctions and preserves vascular integrity

In: EMBO Reports (2021) pp. e51299

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Wick, Antje; Bahr, Oliver; Schuler, Martin; Rohrberg, Kristoffer; Chawla, Sant P.; Janku, Filip; Schiff, David; Heinemann, Volker; Narita, Yoshitaka; Lenz, Heinz-Josef; Ikeda, Masafumi; Ando, Yuichi; Wick, Wolfgang; Steinbach, Joachim P.; Burger, Michael C.; Wenger, Katharina; Lassen, Ulrik; Sankhala, Kamalesh K.; Roggia, Cristiana; Genvresse, Isabelle; Munhoz, Catya; Rentzsch, Christine; Reschke, Susanne; Langer, Simon; Wagner, Markus; Kaulfuss, Stefan; Cai, Charles; Lagkadinou, Eleni; Jeffers, Michael; Peña, Carol; Tabatabai, Ghazaleh

Phase I assessment of safety and therapeutic activity of BAY1436032 in patients with IDH1-mutant solid tumors

In: Clinical Cancer Research Vol. 27 (2021) Nr. 10, pp. 2723 - 2733

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Chen, Jieliang; Li, Yaming; Lai, Fritz; Wang, Yang; Sutter, Kathrin; Dittmer, Ulf; Ye, Jianyu; Zai, Wenjing; Liu, Min; Shen, Fang; Wu, Min; Hu, Kongying; Li, Baocun; Lu, Mengji; Zhang, Xiaonan; Zhang, Jiming; Li, Jianhua; Chen, Qingfeng; Yuan, Zhenghong

Functional Comparison of Interferon-α Subtypes Reveals Potent Hepatitis B Virus Suppression by a Concerted Action of Interferon-α and Interferon-γ Signaling

In: Hepatology Vol. 73 (2021) Nr. 2, pp. 486 - 502

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Kunzmann, Volker; Siveke, Jens; Algül, Hana; Goekkurt, Eray; Siegler, Gabriele; Martens, Uwe; Waldschmidt, Dirk; Pelzer, Uwe; Fuchs, Martin; Kullmann, Frank; Boeck, Stefan; Ettrich, Thomas J; Held, Swantje; Keller, Ralph; Klein, Ingo; Germer, Christoph-Thomas; Stein, Hubert; Friess, Helmut; Bahra, Marcus; Jakobs, Ralf; Hartlapp, Ingo; Heinemann, Volker; German Pancreatic Cancer Working Group (AIO-PAK) and NEOLAP investigators; Stahl, Michael; Mahlmann, Stefan

Nab-paclitaxel plus gemcitabine versus nab-paclitaxel plus gemcitabine followed by FOLFIRINOX induction chemotherapy in locally advanced pancreatic cancer (NEOLAP-AIO-PAK-0113) : a multicentre, randomised, phase 2 trial

In: The Lancet Gastroenterology & Hepatology Vol. 6 (2021) Nr. 2, pp. 128 - 138

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Meurer, Thuja; Crivello, Pietro; Metzing, Maximilian Frederik; Kester, Michel; Megger, Dominik A.; Chen, Weiqiang; van Veelen, PA; van Balen, Peter; Westendorf, Astrid; Homa, Georg; Layer, Sophia E.; Turki, Amin T.; Griffioen, Marieke; Horn, Peter; Sitek, Barbara; Beelen, Dietrich; Falkenburg, J.H.Frederik; Arrieta-Bolaños, Esteban; Fleischhauer, Katharina

Permissive HLA-DPB1 mismatches in HCT depend on immunopeptidome divergence and editing by HLA-DM

In: Blood Vol. 137 (2021) Nr. 7, pp. 923 - 928

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Schuler, Martin

Corrigendum to “Inhibiting fibroblast growth factor receptors in cancer – The next generation”

In: Annals of Oncology Vol. 32 (2021) Nr. 1, pp. 126

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Bebber, Christina M.; Thomas, Emily S.; Stroh, Jenny; Chen, Zhiyi; Androulidaki, Ariadne; Schmitt, Anna; Höhne, Michaela N.; Stüker, Lukas; de Pádua Alves, Cleidson; Khonsari, Armin; Dammert, Marcel A.; Parmaksiz, Fatma; Tumbrink, Hannah L.; Beleggia, Filippo; Sos, Martin L.; Riemer, Jan; George, Julie; Brodesser, Susanne; Thomas, Roman K.; Reinhardt, Christian; von Karstedt, Silvia

Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes

In: Nature Communications Vol. 12 (2021) Nr. 1, pp. 2048

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Küppers, Ralf

Sugar-modified B-cell receptors in DLBCL

In: Blood Vol. 138 (2021) Nr. 17, pp. 1512 - 1514

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Wu, Jun; Liang, Boyun; Chen, Cunrong; Wang, Hua; Fang, Yaohui; Shen, Shu; Yang, Xiaoli; Wang, Baoju; Chen, Liangkai; Chen, Qi; Wu, Yang; Liu, Jia; Yang, Xuecheng; Li, Wei; Zhu, Bin; Zhou, Wenqing; Wang, Huan; Li, Sumeng; Lu, Sihong; Liu, Di; Li, Huadong; Krawczyk, Adalbert; Lu, Mengji; Yang, Dongliang; Deng, Fei; Dittmer, Ulf; Trilling, Mirko; Zheng, Xin

SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19

In: Nature Communications Vol. 12 (2021) Nr. 1, pp. 1813

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Shukla, Shalmali; Haenold, Ronny; Urbánek, Pavel; Frappart, Lucien; Monajembashi, Shamci; Grigaravicius, Paulius; Nagel, Sigrun; Min, Woo Kee; Tapias, Alicia; Kassel, Olivier; Heuer, Heike; Wang, Zhao-Qi; Ploubidou, Aspasia; Herrlich, Peter

TRIP6 functions in brain ciliogenesis

In: Nature Communications Vol. 12 (2021) Nr. 1, 5887

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Rassaf, Tienush; Heusch, Gerd

The West German heart and vascular center at university medicine Essen

In: European Heart Journal Vol. 42 (2021) Nr. 10, pp. 963 - 964

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Lorentino, Francesca; Labopin, Myriam; Ciceri, Fabio; Vago, Luca; Fleischhauer, Katharina; Afanasyev, Boris; Kröger, Nicolaus; Cornelissen, Jan J.; Lovira, Montserrat; Meijer, Ellen; Vitek, Antonin; Elmaagacli, Ahmet; Blaise, Didier; Ruggeri, Annalisa; Chabannon, Christian; Nagler, Arnon; Mohty, Mohamad

Post-transplantation cyclophosphamide GvHD prophylaxis after hematopoietic stem cell transplantation from 9/10 or 10/10 HLA-matched unrelated donors for acute leukemia

In: Leukemia Vol. 35 (2021) Nr. 2, pp. 585 - 594

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Grunewald, Susanne; Klug, Lillian R.; Mühlenberg, Thomas; Lategahn, Jonas; Falkenhorst, Johanna; Town, Ajia; Ehrt, Christiane; Wardelmann, Eva; Hartmann, Wolfgang; Schildhaus, Hans-Ulrich; Treckmann, Jürgen-Walter; Fletcher, Jonathan A.; Jung, Sascha; Czodrowski, Paul; Miller, Stephen; Schmidt-Kittler, Oleg; Rauh, Daniel; Heinrich, Michael C.; Bauer, Sebastian

Resistance to avapritinib in pdgfra-driven gist is caused by secondary mutations in the pdgfra kinase domain

In: Cancer Discovery Vol. 11 (2021) Nr. 1, pp. 108 - 125

Online Full Text: dx.doi.org/ (Open Access)
Somasundaram, Rajasekharan; Connelly, Thomas; Choi, Robin; Choi, Hyeree; Samarkina, Anastasia; Li, Ling; Gregorio, Elizabeth; Chen, Yeqing; Thakur, Rohit; Abdel-Mohsen, Mohamed; Beqiri, Marilda; Kiernan, Meaghan; Perego, Michela; Wang, Fang; Xiao, Min; Brafford, Patricia; Yang, Xue; Xu, Xiaowei; Secreto, Anthony; Danet-Desnoyers, Gwenn; Traum, Daniel; Kaestner, Klaus H.; Huang, Alexander C.; Hristova, Denitsa; Wang, Joshua; Fukunaga-Kalabis, Mizuho; Krepler, Clemens; Ping-Chen, Fang; Zhou, Xiangyang; Gutierrez, Alexis; Rebecca, Vito W.; Vonteddu, Prashanthi; Dotiwala, Farokh; Bala, Shashi; Majumdar, Sonali; Dweep, Harsh; Wickramasinghe, Jayamanna; Kossenkov, Andrew V.; Reyes-Arbujas, Jorge; Santiago, Kenisha; Nguyen, Tran; Griss, Johannes; Keeney, Frederick; Hayden, James; Gavin, Brian J.; Weiner, David; Montaner, Luis J.; Liu, Qin; Peiffer, Lukas; Becker, Jürgen; Burton, Elizabeth M.; Davies, Michael A.; Tetzlaff, Michael T.; Muthumani, Kar; Wargo, Jennifer A.; Gabrilovich, Dmitry; Herlyn, Meenhard

Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy

In: Nature Communications Vol. 12 (2021) Nr. 1, pp. 346

Online Full Text: dx.doi.org/ (Open Access)
Obermann, Mark; Nägel, Steffen; Ose, Claudia; Sonuc, Nilüfer; Scherag, Andre; Storch, Peter; Gaul, Charly; Böger, Andreas; Kraya, Torsten; Jansen, Jan-Peter; Straube, Andreas; Freilinger, Tobias; Kaube, Holger; Jürgens, Tim P; Diener, Hans Christoph; Katsarava, Zaza; Kleinschnitz, Christoph; Holle, Dagny

Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache : A multicentre, double-blind, randomised controlled trial

In: The Lancet Neurology Vol. 20 (2021) Nr. 1, pp. 29 - 37

Online Full Text: dx.doi.org/
Cao, Yingying; Kitanovski, Simo; Küppers, Ralf; Hoffmann, Daniel

UMI or not UMI, that is the question for scRNA-seq zero-inflation

In: Nature Biotechnology Vol. 39 (2021) Nr. 2, pp. 158 - 159

Online Full Text: dx.doi.org/ Online Full Text (Open Access)

2020

Küppers, Ralf; Schadendorf, Dirk; Stein, Lincoln D.; PCAWG Consortium

A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

In: Nature Communications Vol. 11 (2020) 728

Online Full Text: dx.doi.org/ (Open Access)
Küppers, Ralf; Schadendorf, Dirk; Creighton, Chad J.; PCAWG Consortium

High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations

In: Nature Communications Vol. 11 (2020) 736

Online Full Text: dx.doi.org/ (Open Access)
Küppers, Ralf; Schadendorf, Dirk; Cmero, Marek; Macintyre, Geoff; PCAWG Consortium

Inferring structural variant cancer cell fraction

In: Nature Communications Vol. 11 (2020) 730

Online Full Text: dx.doi.org/ (Open Access)
Küppers, Ralf; Schadendorf, Dirk; Shuai, Shimin; Stein, Lincoln D.

Combined burden and functional impact tests for cancer driver discovery using DriverPower

In: Nature Communications Vol. 11 (2020) 734

Online Full Text: dx.doi.org/ (Open Access)
Küppers, Ralf; Schadendorf, Dirk; Reimand, Jüri; PCAWG Drivers and Functional Interpretation Working Group; PCAWG Consortium

Integrative pathway enrichment analysis of multivariate omics data

In: Nature Communications Vol. 11 (2020) 735

Online Full Text: dx.doi.org/ (Open Access)
Küppers, Ralf; Schadendorf, Dirk; Bristow, Robert G.; Boutros, Paul C.; PCAWG Consortium

Divergent mutational processes distinguish hypoxic and normoxic tumours

In: Nature Communications Vol. 11 (2020) 737

Online Full Text: dx.doi.org/ (Open Access)
Küppers, Ralf; Schadendorf, Dirk

Pathway and network analysis of more than 2500 whole cancer genomes

In: Nature Communications Vol. 11 (2020) 729

Online Full Text: dx.doi.org/ (Open Access)
Liu, David; Schilling, Bastian; Liu, Derek; Sucker, Antje; Livingstone, Elisabeth; Jerby-Arnon, Livnat; Zimmer, Lisa; Gutzmer, Ralf; Satzger, Imke; Loquai, Carmen; Grabbe, Stephan; Vokes, Natalie; Margolis, Claire A.; Conway, Jake; He, Meng Xiao; Elmarakeby, Haitham; Dietlein, Felix; Miao, Diana; Tracy, Adam; Gogas, Helen; Goldinger, Simone M.; Utikal, Jochen; Blank, Christian U.; Rauschenberg, Ricarda; von Bubnoff, Dagmar; Krackhardt, Angela; Weide, Benjamin; Haferkamp, Sebastian; Kiecker, Felix; Izar, Ben; Garraway, Levi; Regev, Aviv; Flaherty, Keith; Paschen, Annette; Van Allen, Eliezer M.; Schadendorf, Dirk

Author Correction: Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma

In: Nature Medicine Vol. 26 (2020) Nr. 7, pp. 1147

Online Full Text: dx.doi.org/ (Open Access)
Küppers, Ralf; Schadendorf, Dirk; Feuerbach, Lars; PCAWG Consortium

Genomic footprints of activated telomere maintenance mechanisms in cancer

In: Nature Communications Vol. 11 (2020) 733

Online Full Text: dx.doi.org/ (Open Access)
Current, Kyle; Meyer, Catherine; Magyar, Clara E.; Mona, Christine E.; Almajano, Joel; Slavik, Roger; Stuparu, Andreea D.; Cheng, Chloe; Dawson, David W.; Radu, Caius G.; Czernin, Johannes; Lückerath, Katharina

Investigating PSMA-Targeted Radioligand Therapy Efficacy as a Function of Cellular PSMA Levels and Intratumoral PSMA Heterogeneity

In: Clinical Cancer Research Vol. 26 (2020) Nr. 12, pp. 2946 - 2955

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Nadeu, Ferran; Martin-Garcia, David; Clot, Guillem; Díaz-Navarro, Ander; Duran-Ferrer, Martí; Navarro, Alba; Vilarrasa-Blasi, Roser; Kulis, Marta; Royo, Romina; Gutiérrez-Abril, Jesús; Valdés-Mas, Rafael; López, Cristina; Chapaprieta, Vicente; Puiggros, Montserrat; Castellano, Giancarlo; Costa, Dolors; Aymerich, Marta; Jares, Pedro; Espinet, Blanca; Muntañola, Ana; Ribera-Cortada, Inmaculada; Siebert, Reiner; Colomer, Dolors; Torrents, David; Gine, Eva; López-Guillermo, Armando; Küppers, Ralf; Martin-Subero, Jose I.; Puente, Xose S.; Beà, Sílvia; Campo, Elias

Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypes

In: Blood Vol. 136 (2020) Nr. 12, pp. 1419 - 1432

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Klein, Sebastian; Quaas, Alexander; Noh, Ka-Won; Cartolano, Maria; Abedpour, Nima; Mauch, Cornelia; Quantius, Jennifer; Reinhardt, Hans Christian; Buettner, Reinhard; Peifer, Martin; Helbig, Doris

Integrative Analysis of Pleomorphic Dermal Sarcomas Reveals Fibroblastic Differentiation and Susceptibility to Immunotherapy

In: Clinical Cancer Research Vol. 26 (2020) Nr. 21, pp. 5638 - 5645

Online Full Text: dx.doi.org/ (Open Access)
Hagenacker, Tim; Wurster, Claudia D.; Günther, René; Schreiber-Katz, Olivia; Osmanovic, Alma; Petri, Susanne; Weiler, Markus; Ziegler, Andreas; Kuttler, Josua; Koch, Jan C.; Schneider, Ilka; Wunderlich, Gilbert; Schloss, Natalie; Lehmann, Helmar C.; Cordts, Isabell; Deschauer, Marcus; Lingor, Paul; Kamm, Christoph; Stolte, Benjamin; Pietruck, Lena; Totzeck, Andreas; Kizina, Kathrin; Mönninghoff, Christoph; von Velsen, Otgonzul; Ose, Claudia; Reichmann, Heinz; Forsting, Michael; Pechmann, Astrid; Kirschner, Janbernd; Ludolph, Albert C.; Hermann, Andreas; Kleinschnitz, Christoph

Nusinersen in adults with 5q spinal muscular atrophy : A non-interventional, multicentre, observational cohort study

In: The Lancet Neurology Vol. 19 (2020) Nr. 4, pp. 317 - 325

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Dykun, Iryna; Mahabadi, Amir Abbas; Rassaf, Tienush

A clinical perspective on the 2019 ESC/EAS guidelines for the management of dyslipidaemias: PCSK-9 inhibitors for all?

In: European Heart Journal Vol. 41 (2020) Nr. 24, pp. 2331

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Dummer, Reinhard; Brase, Jan C.; Garrett, James; Campbell, Catarina D.; Gasal, Eduard; Squires, Matthew; Gusenleitner, Daniel; Santinami, Mario; Atkinson, Victoria; Mandalà, Mario; Chiarion-Sileni, Vanna; Flaherty, Keith; Larkin, James; Robert, Caroline; Kefford, Richard; Kirkwood, John M.; Hauschild, Axel; Schadendorf, Dirk; Long, Georgina V.

Adjuvant dabrafenib plus trametinib versus placebo in patients with resected, BRAFV⁶⁰⁰-mutant, stage III melanoma (COMBI-AD) : Exploratory biomarker analyses from a randomised, phase 3 trial

In: The Lancet Oncology Vol. 21 (2020) Nr. 3, pp. 358 - 372

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Balcer, B; Dykun, Iryna; Hendricks, Stefanie; Al-Rashid, Fadi; Totzeck, Matthias; Rassaf, Tienush; Mahabadi, Amir Abbas;

Anemia increases long-term mortality in patients undergoing conventional coronary angiography – the ECAT registry
ESC Congress 2020 – The Digital Experience 29 August – 1 September 2020,

In: European Heart Journal Vol. 41 (2020) Nr. Supplement_2, pp. 1508

Online Full Text: dx.doi.org/
Migden, Michael R.; Khushalani, Nikhil I.; Chang, Anne Lynn S.; Lewis, Karl D.; Schmults, Chrysalyne D.; Hernandez-Aya, Leonel; Meier, Friedegund; Schadendorf, Dirk; Guminski, Alexander; Hauschild, Axel; Wong, Deborah J.; Daniels, Gregory A.; Berking, Carola; Jankovic, Vladimir; Stankevich, Elizabeth; Booth, Jocelyn; Li, Siyu; Weinreich, David M.; Yancopoulos, George D.; Lowy, Israel; Fury, Matthew G.; Rischin, Danny

Cemiplimab in locally advanced cutaneous squamous cell carcinoma : results from an open-label, phase 2, single-arm trial

In: The Lancet Oncology Vol. 21 (2020) Nr. 2, pp. 294 - 305

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Association between Immune-Related Adverse Events and Recurrence-Free Survival among Patients with Stage III Melanoma Randomized to Receive Pembrolizumab or Placebo : A Secondary Analysis of a Randomized Clinical Trial

In: JAMA Oncology Vol. 6 (2020) Nr. 4, pp. 519 - 527

Online Full Text: dx.doi.org/ (Open Access)
Küppers, Ralf; Schadendorf, Dirk

Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 6232

Online Full Text: dx.doi.org/ (Open Access)
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Five-Year Analysis of Adjuvant Dabrafenib plus Trametinib in Stage III Melanoma

In: The New England Journal of Medicine Vol. 383 (2020) Nr. 12, pp. 1139 - 1148

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Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility

In: Nature Genetics Vol. 52 (2020) Nr. 5, pp. 494 - 504

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Totzeck, Matthias; Siebermair, Johannes; Rassaf, Tienush; Rischpler, Christoph

Cardiac fibroblast activation detected by positron emission tomography/computed tomography as a possible sign of cardiotoxicity

In: European Heart Journal Vol. 41 (2020) Nr. 9, pp. 1060

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Schetelig, Johannes; Baldauf, Henning; Heidenreich, Falk; Massalski, Carolin; Frank, Sandra; Sauter, Jürgen; Stelljes, Matthias; Ayuk, Francis Ayuketang; Bethge, Wolfgang A.; Bug, Gesine; Klein, Stefan; Wendler, Sarah; Lange, Vinzenz; de Wreede, Liesbeth C.; Fürst, Daniel; Kobbe, Guido; Ottinger, Hellmut; Beelen, Dietrich; Mytilineos, Joannis; Fleischhauer, Katharina; Schmidt, Alexander H.; Bornhäuser, Martin

External validation of models for KIR2DS1/KIR3DL1-informed selection of hematopoietic cell donors fails

In: Blood Vol. 135 (2020) Nr. 16, pp. 1386 - 1395

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Melms, Johannes C.; Vallabhaneni, Sreeram; Mills, Caitlin E.; Yapp, Clarence; Chen, Jia-Yun; Morelli, Eugenio; Waszyk, Patricia; Kumar, Sushil; Deming, Derrick; Moret, Nienke; Rodriguez, Steven; Subramanian, Kartik; Rogava, Meri; Cartwright, Adam N.R.; Luoma, Adrienne; Mei, Shaolin; Brinker, Titus J.; Miller, David M.; Spektor, Alexander; Schadendorf, Dirk; Riggi, Nicolo; Wucherpfennig, Kai W.; Sorger, Peter K.; Izar, Benjamin

Inhibition of haspin kinase promotes cell-intrinsic and extrinsic antitumor activity

In: Cancer Research Vol. 80 (2020) Nr. 4, pp. 798 - 810

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Küppers, Ralf; Schadendorf, Dirk; Morris, Quaid D.; PCAWG Consortium

Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig

In: Nature Communications Vol. 11 (2020) 731

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Zhuang, Yuan; Xu, Haifeng C.; Shinde, Prashant V.; Warfsmann, Jens; Vasilevska, Jelena; Sundaram, Balamurugan; Behnke, Kristina; Huang, Jun; Hoell, Jessica I.; Borkhardt, Arndt; Pfeffer, Klaus; Taha, Mohamed S.; Herebian, Diran; Mayatepek, Ertan; Brenner, Dirk; Ahmadian, Mohammad Reza; Keitel, Verena; Wieczorek, Dagmar; Häussinger, Dieter; Pandyra, Aleksandra A.; Lang, Karl S.; Lang, Philipp A.

Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury

In: Gut Vol. 69 (2020) Nr. 1, pp. 133 - 145

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Bodei, Lisa; Schöder, Heiko; Baum, Richard P; Herrmann, Ken; Strosberg, Jonathan; Caplin, Martyn; Öberg, Kjell; Modlin, Irvin M

Molecular profiling of neuroendocrine tumours to predict response and toxicity to peptide receptor radionuclide therapy

In: The Lancet Oncology Vol. 21 (2020) Nr. 9, pp. e431 - e443

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Non-classical monocyte homing to the gut via α4β7 integrin mediates macrophage-dependent intestinal wound healing

In: Gut Vol. 69 (2020) pp. 252 - 263

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Cabrita, Rita; Lauss, Martin; Sanna, Adriana; Donia, Marco; Skaarup Larsen, Mathilde; Mitra, Shamik; Johansson, Iva; Phung, Bengt; Harbst, Katja; Vallon-Christersson, Johan; van Schoiack, Alison; Lövgren, Kristina; Warren, Sarah; Jirström, Karin; Olsson, Håkan; Pietras, Kristian; Ingvar, Christian; Isaksson, Karolin; Schadendorf, Dirk; Schmidt, Henrik; Bastholt, Lars; Carneiro, Ana; Wargo, Jennifer A.; Svane, Inge Marie; Jönsson, Göran

Author Correction: Tertiary lymphoid structures improve immunotherapy and survival in melanoma

In: Nature Vol. 580 (2020) Nr. 7801, pp. E1

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Bazinet, Michel; Pântea, Victor; Placinta, Gheorghe; Moscalu, Iurie; Cebotarescu, Valentin; Cojuhari, Lilia; Jimbei, Pavlina; Iarovoi, Liviu; Smesnoi, Valentina; Musteata, Tatiana; Jucov, Alina; Dittmer, Ulf; Krawczyk, Adalbert; Vaillant, Andrew

Safety and Efficacy of 48 Weeks REP 2139 or REP 2165, Tenofovir Disoproxil, and Pegylated Interferon Alfa-2a in Patients With Chronic HBV Infection Naïve to Nucleos(t)ide Therapy

In: Gastroenterology Vol. 158 (2020) Nr. 8, pp. 2180 - 2194

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Mladenov, Emil; Staudt, Christian; Soni, Aashish; Murmann-Konda, Tamara; Siemann-Loekes, Maria; Iliakis, George

Strong suppression of gene conversion with increasing DNA double-strand break load delimited by 53BP1 and RAD52

In: Nucleic Acids Research Vol. 48 (2020) Nr. 4, pp. 1905 - 1924

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Gremke, Niklas; Polo, Pierfrancesco; Dort, Aaron; Schneikert, Jean; Elmshäuser, Sabrina; Brehm, Corinna; Klingmüller, Ursula; Schmitt, Anna; Reinhardt, Hans Christian; Timofeev, Oleg; Wanzel, Michael; Stiewe, Thorsten

mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability

In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 4684

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Zimmer, Lisa; Livingstone, Elisabeth; Hassel, Jessica C.; Fluck, Michael; Eigentler, Thomas; Loquai, Carmen; Haferkamp, Sebastian; Gutzmer, Ralf; Meier, Friedegund; Mohr, Peter; Hauschild, Axel; Schilling, Bastian; Menzer, Christian; Kieker, Felix; Dippel, Edgar; Rösch, Alexander; Simon, Jan-Christoph; Conrad, Beate; Körner, Silvia; Windemuth-Kieselbach, Christine; Schwarz, Leonora; Garbe, Claus; Becker, Jürgen C.; Schadendorf, Dirk; Berking, Carola; Herbst, Rudolf A.; Martens, Uwe M; Sell, Sabine; Stadler, Rudolf; Terheyden, Patrick; Utikal, Jochen

Adjuvant nivolumab plus ipilimumab or nivolumab monotherapy versus placebo in patients with resected stage IV melanoma with no evidence of disease (IMMUNED) : A randomised, double-blind, placebo-controlled, phase 2 trial

In: Lancet Vol. 395 (2020) Nr. 10236, pp. 1558 - 1568

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Heinrich, Michael C.; Jones, Robin L.; von Mehren, Margaret; Schöffski, Patrick; Serrano, César; Kang, Yoon-Koo; Cassier, Philippe A.; Mir, Olivier; Eskens, Ferry; Tap, William D.; Rutkowski, Piotr; Chawla, Sant P.; Trent, Jonathan; Tugnait, Meera; Evans, Erica K.; Lauz, Tamieka; Zhou, Teresa; Roche, Maria; Wolf, Beni B.; Bauer, Sebastian; George, Suzanne

Avapritinib in advanced PDGFRA D842V-mutant gastrointestinal stromal tumour (NAVIGATOR) : A multicentre, open-label, phase 1 trial

In: The Lancet Oncology Vol. 21 (2020) Nr. 7, pp. 935 - 946

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Chabriat, Hugues; Bassetti, Claudio L; Marx, Ute; Audoli-Inthavong, Marie-Laure; Sors, Aurore; Lambert, Estelle; Wattez, Marine; Hermann, Dirk M.; Diener, Hans Christoph; Restore Brain Study Investigators

Safety and efficacy of GABAA α5 antagonist S44819 in patients with ischaemic stroke : A multicentre, double-blind, randomised, placebo-controlled trial

In: The Lancet Neurology Vol. 19 (2020) Nr. 3, pp. 226 - 233

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Prognostic impact of baseline tumour immune infiltrate on disease-free survival in patients with completely resected, BRAFv⁶⁰⁰ mutation–positive melanoma receiving adjuvant vemurafenib

In: Annals of Oncology Vol. 31 (2020) Nr. 1, pp. 153 - 159

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Dummer, Reinhard; Ascierto, Paolo A.; Nathan, Paul; Robert, Caroline; Schadendorf, Dirk

Rationale for Immune Checkpoint Inhibitors plus Targeted Therapy in Metastatic Melanoma : A Review

In: JAMA Oncology Vol. 6 (2020) Nr. 12, pp. 1957 - 1966

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Blay, Jean-Yves; Serrano, César; Heinrich, Michael C.; Zalcberg, John; Bauer, Sebastian; Gelderblom, Hans; Schöffski, Patrick; Jones, Robin L; Attia, Steven; D'Amato, Gina; Chi, Ping; Reichardt, Peter; Meade, Julie; Shi, Kelvin; Ruiz-Soto, Rodrigo; George, Suzanne; von Mehren, Margaret

Ripretinib in patients with advanced gastrointestinal stromal tumours (INVICTUS) : a double-blind, randomised, placebo-controlled, phase 3 trial

In: The Lancet Oncology Vol. 21 (2020) Nr. 7, pp. 923 - 934

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Wiesweg, Marcel; Schuler, Martin; Schildhaus, Hans-Ulrich

Crizotinib in ROS1 and MET deregulated NSCLC-letter

In: Clinical Cancer Research Vol. 26 (2020) Nr. 7, pp. 1774

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Adomati, Tom; Cham, Lamin B.; Hamdan, Thamer A.; Bhat, Hilal; Duhan, Vikas; Li, Fanghui; Ali, Murtaza; Lang, Elisabeth; Huang, Anfei; Naser, Eyad; Khairnar, Vishal; Friedrich, Sarah-Kim; Lang, Judith; Friebus-Kardash, Justa; Bergerhausen, Michael; Schiller, Maximilian; Machlah, Yara Maria; Lang, Florian; Häussinger, Dieter; Ferencik, Stanislav; Hardt, Cornelia; Lang, Philipp A.; Lang, Karl S.

Dead Cells Induce Innate Anergy via Mertk after Acute Viral Infection

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Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4) : A randomised, phase 2/3 trial

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HDAC8 regulates a stress response pathway in melanoma to mediate escape from BRAF inhibitor therapy

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Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation

In: Nature Medicine Vol. 25 (2019) Nr. 4, pp. 603 - 611

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Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma

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MMP2/MMP9-mediated CD100 shedding is crucial for inducing intrahepatic anti-HBV CD8 T cell responses and HBV clearance

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Reply [Letter to the Editor: Characterization of CD169+ Macrophages in Liver Regeneration: Tissue Distribution and Fate?]

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Schadendorf, Dirk; Melanoma GWAS Consortium

Publisher Correction : Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 299

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The X-Linked DDX3X RNA Helicase Dictates Translation Reprogramming and Metastasis in Melanoma

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Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity

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Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms Across Eight Psychiatric Disorders

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Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity

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Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis

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Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death

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Five-year outcomes with dabrafenib plus trametinib in metastatic melanoma

In: The New England Journal of Medicine Vol. 381 (2019) Nr. 7, pp. 626 - 636

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Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response

In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 2312

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Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

In: The New England Journal of Medicine Vol. 381 (2019) Nr. 16, pp. 1535 - 1546

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Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

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Final results of a multicenter, open-label phase 2 clinical trial (MYR203) to assess safety and efficacy of myrcludex B in cwith PEG-interferon Alpha 2a in patients with chronic HBV/HDV co-infection

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Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma

In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 1459

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MDM4 Is Targeted by 1q Gain and Drives Disease in Burkitt Lymphoma

In: Cancer Research Vol. 79 (2019) Nr. 12, pp. 3125 - 3138

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Machine learning-based predictors for immune checkpoint inhibitor therapy of non-small-cell lung cancer

In: Annals of Oncology Vol. 30 (2019) Nr. 4, pp. 655 - 657

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Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins

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Melanoma extracellular vesicles generate immunosuppressive myeloid cells by upregulating PD-L1 via TLR4 signaling

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Pexidartinib versus placebo for advanced tenosynovial giant cell tumour (ENLIVEN) : a randomised phase 3 trial

In: Lancet Vol. 394 (2019) Nr. 10197, pp. 478 - 487

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Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS-Mutant Pancreatic and Colorectal Cancer

In: Cancer Research Vol. 79 (2019) Nr. 9, pp. 2367 - 2378

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Prostate-specific membrane antigen ligand positron emission tomography in men with nonmetastatic castration-resistant prostate cancer

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Patient-reported outcomes in patients with resected, high-risk melanoma with BRAFV600E or BRAFV600K mutations treated with adjuvant dabrafenib plus trametinib (COMBI-AD) : a randomised, placebo-controlled, phase 3 trial

In: The Lancet Oncology Vol. 20 (2019) Nr. 5, pp. 701 - 710

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Schadendorf, Dirk; Livingstone, Elisabeth; Zimmer, Lisa

Treatment in metastatic melanoma : Time to re-think

In: Annals of Oncology Vol. 30 (2019) Nr. 4, pp. 501 - 503

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Publisher Correction: Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response

In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 2768

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Mutations in Hepatitis D Virus Allow It to Escape Detection by CD8⁺ T Cells and Evolve at the Population Level

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Publisher Correction: Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 299

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UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors

In: Cell Vol. 176 (2019) Nr. 3, pp. 505 - 519.e22

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Totzeck, Matthias; Mahabadi, Amir Abbas; Schlosser, Thomas Wilfried; Rassaf, Tienush

Weightlifting unmasks high-risk coronary anomaly

In: European Heart Journal Vol. 40 (2019) Nr. 1, pp. 72

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Krawczyk, Adalbert; Bazinet, Michel; Pantea, Victor; Cotler, Scott; Dahari, Harel; Shekhtman, Louis; Jimbei, Pavlina; Cojuhari, Lilia; Cebotarescu, Valentin; Uprichard, Susan; Vaillant, Andrew

Understanding HDV and HBsAg kinetics during nucleic acid polymer REP 2139 mono-therapy in HBeAg-negative chronic HBV/HDV co-infected patients via mathematical modeling

In: Journal of Hepatology Vol. 70 (2019) Nr. 1 Suppl., pp. e463

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Alpelisib Plus Fulvestrant in PIK3CA -Altered and PIK3CA -Wild-Type Estrogen Receptor-Positive Advanced Breast Cancer : A Phase 1b Clinical Trial

In: JAMA Oncology Vol. 5 (2019) Nr. 2, pp. e184475

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Defective homologous recombination DNA repair as therapeutic target in advanced chordoma

In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 1635

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Fendler, Wolfgang P.; Calais, Jeremie; Eiber, Matthias; Flavell, Robert R.; Mishoe, Ashley; Feng, Felix Y.; Nguyen, Hao G.; Reiter, Robert E.; Rettig, Matthew B.; Okamoto, Shozo; Emmett, Louise; Zacho, Helle D.; Ilhan, Harun; Wetter, Axel; Rischpler, Christoph; Schoder, Heiko; Burger, Irene A.; Gartmann, Jeannine; Smith, Raven; Small, Eric J.; Slavik, Roger; Carroll, Peter R.; Herrmann, Ken; Czernin, Johannes; Hope, Thomas A.

Assessment of ⁶⁸Ga-PSMA-11 PET Accuracy in Localizing Recurrent Prostate Cancer : A Prospective Single-Arm Clinical Trial

In: JAMA Oncology Vol. 5 (2019) Nr. 6, pp. 856 - 863

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Ascierto, Paolo A.; Long, Georgina V.; Robert, Caroline; Brady, Benjamin; Dutriaux, Caroline; Di Giacomo, Anna Maria; Mortier, Laurent; Hassel, Jessica C.; Rutkowski, Piotr; McNeil, Catriona; Kalinka-Warzocha, Ewa; Savage, Kerry J.; Hernberg, Micaela M.; Lebbé, Celeste; Charles, Julie; Mihalcioiu, Catalin; Chiarion-Sileni, Vanna; Mauch, Cornelia; Cognetti, Francesco; Ny, Lars; Arance, Ana; Svane, Inge Marie; Schadendorf, Dirk; Gogas, Helen; Saci, Abdel; Jiang, Joel; Rizzo, Jasmine; Atkinson, Victoria

Survival Outcomes in Patients with Previously Untreated BRAF Wild-Type Advanced Melanoma Treated with Nivolumab Therapy : Three-Year Follow-up of a Randomized Phase 3 Trial

In: JAMA Oncology Vol. 5 (2019) Nr. 2, pp. 187 - 194

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Otxoa-de-Amezaga, Amaia; Miró-Mur, Francesc; Pedragosa, Jordi; Gallizioli, Mattia; Justicia, Carles; Gaja-Capdevila, Núria; Ruíz-Jaen, Francisca; Salas-Perdomo, Angélica; Bosch, Anna; Calvo, Maria; Márquez-Kisinousky, Leonardo; Denes, Adam; Gunzer, Matthias; Planas, Anna M.

Microglial cell loss after ischemic stroke favors brain neutrophil accumulation

In: Acta Neuropathologica Vol. 137 (2019) Nr. 2, pp. 321 - 341

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Dmitrieva-Posocco, Oxana; Dzutsev, Amiran; Posocco, David F.; Hou, Vivianty; Yuan, Wuxing; Thovarai, Vishal; Mufazalov, Ilgiz A.; Gunzer, Matthias; Shilovskiy, Igor P.; Khaitov, Musa R.; Trinchieri, Giorgio; Waisman, Ari; Grivennikov, Sergei I.

Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer

In: Immunity Vol. 50 (2019) Nr. 1, pp. 166 - 180.e7

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Urbonas, Vincas; Schadendorf, Dirk; Zimmer, Lisa; Danson, Sarah J.; Marshall, Ernest; Corrie, Pippa G.; Wheater, Matthew J.; Plummer, E.; Mauch, Cornelia; Scudder, Claire; Goff, Matthew; Love, Sharon B.; Mohammed, S.B.; Middleton, Mark R.

Paclitaxel with or without trametinib or pazopanib in advanced wild-type BRAF melanoma (PACMEL) : a multicentre, open-label, randomised, controlled phase II trial

In: Annals of Oncology Vol. 30 (2019) Nr. 2, pp. 317 - 324

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Niemeyer, Johannes; Mentrup, Torben; Heidasch, Ronny; Müller, Stephan A; Biswas, Uddipta; Meyer, Rieke; Papadopoulou, Alkmini A.; Dederer, Verena; Haug-Kröper, Martina; Adamski, Vivian; Lüllmann-Rauch, Renate; Bergmann, Martin; Mayerhofer, Artur; Saftig, Paul; Wennemuth, Gunther; Jessberger, Rolf; Fluhrer, Regina; Lichtenthaler, Stefan F.; Lemberg, Marius K.; Schröder, Bernd

The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban

In: EMBO Reports Vol. 20 (2019) Nr. 3, pp. e46449

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George, Suzanne; Bauer, Sebastian; Jones, Robin L.; Serrano, Christina S.; Mehren, Margaret M. von; Kang, Y.-K.; Schöffski, Patrick; Cassier, Philippe A.; Eskens, Ferry A.; Mir, Olivier; Tap, William D.; Chawla, Sant P.; Rutkowski, Piotr; Shi, H.; Schmidt-Kittler, Oleg; Mar, B.; Heinrich, Michael

Correlation of ctDNA and response in patients (pts) with PDGFRα D842 GIST treated with avapritinib

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii584

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Lakatos, Gábor; Lee, K.; Siveke, Jens; Blanc, Jean Frédéric; Macarulla Mercadé, Teresa; Dean, Andrew; Bodoky, Gyorgy; Mirakhur, Beloo; Chen, Jie; Wang-Gillam, Andrea; Chen, Li Li; Jong, Floris A. de

Prognostic value of baseline biliary stents on outcomes in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) in the NAPOLI-1 trial

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 5, pp. v42

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Langer, Samantha K; Cull, Alyssa; Wossidlo, Natalie; Klump, Hannes; Horn, Peter; Heinrichs, Stefan;

Distinct Gene Expression Patterns Drive Proliferation of Dominant-Negative RUNX1 Immortalized HSPCs
60th ASH Annual Meeting; December 1-4, 2018; San Diego, USA,

In: Blood Vol. 132 (2018) Nr. Supplement 1, pp. 1795 - 1795

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Krawczyk, Adalbert; et.al.

Establishment of High Rates of Functional Control and Reversal of Fibrosis Following Treatment of Hbeag Negative Chronic HBV Infection with REP 2139-Mg / REP 2165-Mg, Tenofovir Disoproxil Fumarate and Pegylated Interferon Alpha-2a

In: Hepatology Vol. 68 (2018) Nr. S1, pp. 234A - 235A

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Grünwald, Viktor; Schuler, Martin H.; Schöffski, Patrick; Kopp, Hans-Georg; Bauer, Sebastian; Kasper, Bernd; Lindner, Lars H.; Chemnitz, Jens M.; Crysandt, Martina; Stein, Alexander; Steffen, B.; Richter, Stephan; Kneba, Michael; Egerer, Gerlinde; Zimmermann, S.; Karch, Annika; Kunitz, Annegret

Health-related quality of life (HR-QoL) in elderly soft tissue sarcoma (STS) patients from the randomized phase II EPAZ study comparing pazopanib (PAZ) and doxorubicin (DOX) in first line

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii577

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Bayo, Juan; Tran, Tram Anh; Wang, Lei; Peña-Llopis, Samuel; Das, Amit K.; Martinez, Elisabeth D.

Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks

In: Cell Reports Vol. 25 (2018) Nr. 4, pp. 1040 - 1050.e5

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Hodi, Frank S.; Chiarion-Sileni, Vanna; Gonzalez, René C.; Grob, Jean J.; Rutkowski, Piotr; Cowey, Charles L.; Lao, Christopher D.; Schadendorf, Dirk; Wagstaff, John; Dummer, Reinhard G.; Ferrucci, Pier F.; Smylie, Michael; Hill, A. G.; Hogg, David; Márquez-Rodas, Iván; Jiang, Joel; Rizzo, Jasmine I.; Larkin, James M. G.; Wolchok, J.

Overall survival at 4 years of follow-up in a phase III trial of nivolumab plus ipilimumab combination therapy in advanced melanoma (CheckMate 067)

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii735

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Schadendorf, Dirk; et.al.

Updated relapse-free survival (RFS) and biomarker analysis in the COMBI-AD trial of adjuvant dabrafenib plus trametinib (D plus T) in patients (pts) with resected BRAF V600-mutant stage III melanoma

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8,
Bauer, Sebastian; George, Suzanne; Kang, Y.-K.; Tap, William D.; Zhou, T.; Picazio, N.; Boral, Andy L.; Heinrich, Michael

VOYAGER : An open-label, randomised, phase III study of avapritinib vs regorafenib in patients (pts) with locally advanced (adv) metastatic or unresectable gastrointestinal stromal tumour (GIST)

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii595

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Long, Georgina V.; Hauschild, Axel; Santinami, Mario; Atkinson, Victoria G.; Mandala, Mario; Chiarion-Sileni, Vanna; Larkin, James M. G.; Robert, Caroline; Schadendorf, Dirk; Dasgupta, Kohinoor; Shilkrut, Mark; Garrett, James; Brase, Jan C.; Kefford, Rick F.; Kirkwood, John M.; Dummer, Reinhard G.

Updated relapse-free survival (RFS) and biomarker analysis in the COMBI-AD trial of adjuvant dabrafenib + trametinib (D + T) in patients (pts) with resected BRAF V600-mutant stage III melanoma

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii734 - viii735

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Díaz-Carballo, David; Saka, Sahitya; Klein, Jacqueline; Rennkamp, Tobias; Acikelli, Ali H.; Malak, Sascha; Jastrow, Holger; Wennemuth, Gunther; Tempfer, Clemens; Schmitz, Inge; Tannapfel, Andrea; Strumberg, Dirk

A distinct oncogenerative multinucleated cancer cell serves as a source of stemness and tumor heterogeneity

In: Cancer Research Vol. 78 (2018) Nr. 9, pp. 2318 - 2331

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Schöffski, Patrick; Wozniak, A.; Kasper, B.; Aamdal, S.; Leahy, M.G.; Rutkowski, P.; Bauer, Sebastian; Gelderblom, H.; Italiano, A.; Lindner, L.H.; Hennig, I.; Strauss, S.; Zakotnik, B.; Anthoney, A.; Albiges, L.; Blay, J.-Y.; Reichardt, P.; Sufliarsky, J.; van der Graaf, W.T.A.; Debiec-Rychter, M.; Sciot, R.; Van Cann, T.; Marréaud, S.; Raveloarivahy, T.; Collette, S.; Stacchiotti, S.

Activity and safety of crizotinib in patients with alveolar soft part sarcoma with rearrangement of TFE3 : European Organization for Research and Treatment of Cancer (EORTC) phase II trial 90101 'CREATE'

In: Annals of Oncology Vol. 29 (2018) Nr. 3, pp. 758 - 765

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Eggermont, Alexander M.M.; Blank, Christian U.; Mandala, Mario; Long, Georgina V.; Atkinson, Victoria; Dalle, Stéphane; Haydon, Andrew; Lichinitser, Mikhail; Khattak, Adnan; Carlino, Matteo S.; Sandhu, Shahneen; Larkin, James; Puig, Susana; Ascierto, Paolo A.; Rutkowski, Piotr; Schadendorf, Dirk; Koornstra, Rutger; Hernandez-Aya, Leonel; Maio, Michele; Van Den Eertwegh, Alfonsus J. M.; Grob, Jean-Jacques; Gutzmer, Ralf; Jamal, Rahima; Lorigan, Paul; Ibrahim, Nageatte; Marreaud, Sandrine; Van Akkooi, Alexander C. J.; Suciu, Stefan; Robert, Caroline

Adjuvant pembrolizumab versus placebo in resected stage III melanoma

In: The New England Journal of Medicine Vol. 378 (2018) Nr. 19, pp. 1789 - 1801

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Maio, Michele; Lewis, Karl; Demidov, Lev; Mandalà, Mario; Bondarenko, Igor; Ascierto, Paolo A; Herbert, Christopher; Mackiewicz, Andrzej; Rutkowski, Piotr; Guminski, Alexander; Goodman, Grant R; Simmons, Brian; Ye, Chenglin; Yan, Yibing; Schadendorf, Dirk; BRIM8 Investigators

Adjuvant vemurafenib in resected, BRAF mutation-positive melanoma (BRIM8) : a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial

In: The Lancet Oncology Vol. 19 (2018) Nr. 4, pp. 510 - 520

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Atkinson, Victoria G.; Hauschild, Axel; Santinami, Mario; Mandala, Mario; Chiarion Sileni, Vanna; Larkin, James M. G.; Nyakas, Marta S.; Dutriaux, Caroline; Haydon, Andrew M. M.; Mortier, Laurent; Robert, Caroline; Schachter, Jacob M.; Schadendorf, Dirk; Feng, X.; Jong, Egbert de; Mookerjee, Bijoyesh P.; Kefford, Rick F.; Dummer, Reinhard G.; Kirkwood, John M.; Long, Georgina V.

Adverse events (AEs) over time in patients (pts) treated with adjuvant dabrafenib plus trametinib (D + T) or placebo (Pbo) in the COMBI-AD trial

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii446

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Schotten, C.; Bechmann, Lars Peter; Manka, Paul; Theysohn, Jens; Dechene, Alexander; El Fouly, A.; Muller, S.; Schulze, Maren; Neumann, U.; Radunz, S.; Heider, Dominik; Canbay, Aliekber; Gerken, Guido; Herrmann, Ken; Wedemeyer, Heiner; Best, Jan

Extrahepatic Comorbidities Do Not Alter the Safety and Efficacy of Radioembolization of NAFLD-Associated HCC

In: Hepatology Vol. 68 (2018) Nr. Suppl. 1, pp. 852A - 853A
Horst, Andrea Kristina; Wegscheid, Claudia; Schaefers, Christoph; Schiller, Birgit; Neumann, Katrin; Lunemann, Sebastian; Langeneckert, Annika E; Oldhafer, Karl J; Weiler-Normann, Christina; Lang, Karl S.; Singer, Bernhard B.; Altfeld, Marcus; Diehl, Linda; Tiegs, Gisa

Carcinoembryonic antigen-related cell adhesion molecule 1 controls IL-2-dependent regulatory T-cell induction in immune-mediated hepatitis in mice

In: Hepatology Vol. 68 (2018) Nr. 1, pp. 200 - 214

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Lee, K.; Bodoky, Gyorgy; Blanc, Jean Frédéric; Siveke, Jens; Macarulla Mercade, T.; Wang-Gillam, Andrew; Chen, L.; Mirakhur, Beloo; Chen, Jie; Jong, Floris A. de

Decreased appetite (DA) at baseline impacts prognosis in the NAPOLI-1 phase 3 study in metastatic pancreatic ductal adenocarcinoma (mPDAC)

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 5, pp. v42 - v43

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Schadendorf, Dirk; Van Akkooi, Alexander; Berking, Carola; Griewank, Klaus; Gutzmer, Ralf; Hauschild, Axel; Stang, Andreas; Rösch, Alexander; Ugurel, Selma

Melanoma

In: Lancet Vol. 392 (2018) Nr. 10151, pp. 971 - 984

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Grob, Jean Jacques; Garbe, Claus; Ascierto, Paolo; Larkin, James; Dummer, Reinhard; Schadendorf, Dirk

Adjuvant melanoma therapy with new drugs : Should physicians continue to focus on metastatic disease or use it earlier in primary melanoma?

In: The Lancet Oncology Vol. 19 (2018) Nr. 12, pp. e720 - e725

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Bone sarcomas : ESMO-PaedCan-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 4, pp. iv79 - iv95

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Gharun, Kourosh; Senges, Julia; Seidl, Maximilian; Lösslein, Anne; Kolter, Julia; Lohrmann, Florens; Fliegauf, Manfred; Elgizouli, Magdeldin; Alber, Marco; Vavra, Martina; Schachtrup, Kristina; Illert, Anna L; Gilleron, Martine; Kirschning, Carsten Jürgen; Triantafyllopoulou, Antigoni; Henneke, Philipp

Corrigendum: Mycobacteria exploit nitric oxide-induced transformation of macrophages into permissive giant cells

In: EMBO Reports Vol. 19 (2018) Nr. 12, pp. e47190

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Kugel, Curtis H.; Douglass, Stephen M.; Webster, Marie R.; Kaur, Amanpreet; Liu, Qin; Yin, Xiangfan; Weiss, Sarah A.; Darvishian, Farbod; Al-Rohil, Rami N.; Ndoye, Abibatou; Behera, Reeti; Alicea, Gretchen M.; Ecker, Brett L.; Fane, Mitchell; Allegrezza, Michael J.; Svoronos, Nikolaos; Kumar, Vinit; Wang, Daniel Y.; Somasundaram, Rajasekharan; Hu-Lieskovan, Siwen; Ozgun, Alpaslan; Herlyn, Meenhard; Conejo-Garcia, Jose R.; Gabrilovich, Dmitry; Stone, Erica L.; Nowicki, Theodore S.; Sosman, Jeffrey; Rai, Rajat; Carlino, Matteo S.; Long, Georgina V.; Marais, Richard; Ribas, Antoni; Eroglu, Zeynep; Davies, Michael A.; Schilling, Bastian; Schadendorf, Dirk; Xu, Wei; Amaravadi, Ravi K.; Menzies, Alexander M.; McQuade, Jennifer L.; Johnson, Douglas B.; Osman, Iman; Weeraratna, Ashani T.

Age correlates with response to anti-PD1, reflecting age-related differences in intratumoral effector and regulatory T-Cell populations

In: Clinical Cancer Research Vol. 24 (2018) Nr. 21, pp. 5347 - 5356

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Gulbins, Anne; Schumacher, Fabian; Becker, Katrin Anne; Wilker, Barbara; Soddemann, Matthias; Boldrin, Francesco; Müller, Christian P.; Edwards, Michael J.; Goodman, Michael; Caldwell, Charles C.; Kleuser, Burkhard; Kornhuber, Johannes; Szabo, Ildiko; Gulbins, Erich

Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide

In: Molecular Psychiatry Vol. 23 (2018) Nr. 12, pp. 2324 - 2346

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McQuade, Jennifer L; Daniel, Carrie R; Hess, Kenneth R; Mak, Carmen; Wang, Daniel Y; Rai, Rajat R; Park, John J; Haydu, Lauren E; Spencer, Christine; Wongchenko, Matthew; Lane, Stephen; Lee, Dung-Yang; Kaper, Mathilde; McKean, Meredith; Beckermann, Kathryn E; Rubinstein, Samuel M; Rooney, Isabelle; Musib, Luna; Budha, Nageshwar; Hsu, Jessie; Nowicki, Theodore S; Avila, Alexandre; Haas, Tomas; Puligandla, Maneka; Lee, Sandra; Fang, Shenying; Wargo, Jennifer A; Gershenwald, Jeffrey E; Lee, Jeffrey E; Hwu, Patrick; Chapman, Paul B; Sosman, Jeffrey A; Schadendorf, Dirk; Grob, Jean-Jacques; Flaherty, Keith T; Walker, Dana; Yan, Yibing; McKenna, Edward; Legos, Jeffrey J; Carlino, Matteo S; Ribas, Antoni; Kirkwood, John M; Long, Georgina V; Johnson, Douglas B; Menzies, Alexander M; Davies, Michael A

Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy : a retrospective, multicohort analysis

In: The Lancet Oncology Vol. 19 (2018) Nr. 3, pp. 310 - 322

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Author Correction : The landscape of genomic alterations across childhood cancers

In: Nature Vol. 559 (2018) Nr. 7714, pp. E10

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Sauter, Reinhard J.; Sauter, Manuela; Reis, Edimara S.; Emschermann, Frederic N.; Nording, Henry; Ebenhöch, Sonja; Kraft, Peter; Münzer, Patrick; Mauler, Maximilian; Rheinlaender, Johannes; Madlung, Johannes; Edlich, Frank; Schäffer, Tilman E.; Meuth, Sven G.; Duerschmied, Daniel; Geisler, Tobias; Borst, Oliver; Gawaz, Meinrad; Kleinschnitz, Christoph; Lambris, John D.; Langer, Harald F.

Functional relevance of the anaphylatoxin receptor C3aR for platelet function and arterial thrombus formation marks an intersection point between innate immunity and thrombosis

In: Circulation Vol. 138 (2018) Nr. 16, pp. 1720 - 1735

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Gulbins, Anne; Schumacher, Fabian; Becker, Katrin Anne; Wilker, Barbara; Soddemann, Matthias; Boldrin, Francesco; Müller, Christian P.; Edwards, Michael J.; Goodman, Michael; Caldwell, Charles C.; Kleuser, Burkhard; Kornhuber, Johannes; Szabo, Ildiko; Gulbins, Erich

Antidepressants regulate autophagy by targeting acid sphingomyelinase

In: Molecular Psychiatry Vol. 23 (2018) Nr. 12, pp. 2251

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Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

In: Nature Communications Vol. 9 (2018) Nr. 1, pp. 4774

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Macurulla Mercade, Teresa; Wang-Gillam, Andrea; Chen, L.; Blanc, Jean Frédéric; Lee, K.; Bodoky, Gyorgy; Dean, Andrew; Chen, Jie; Mirakhur, Beloo; Siveke, Jens; de Jong, Floris A.

The effect of best response to prior anticancer therapy on efficacy outcomes in the NAPOLI-1 trial of patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) previously treated with gemcitabine-based therapy

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 5, pp. v42

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Dummer, Reinhard; Ascierto, Paolo A.; Gogas, Helen J.; Arance, Ana; Mandala, Mario; Liszkay, Gabriella; Garbe, Claus; Schadendorf, Dirk; Krajsova, Ivana; Gutzmer, Ralf; Chiarion Sileni, Vanna; Dutriaux, Caroline; de Groot, Jan Willem B.; Yamazaki, Naoya; Loquai, Carmen; Moutouh-de Parseval, Laure A.; Pickard, Michael D.; Sandor, Victor; Robert, Caroline; Flaherty, Keith T.

Overall survival in patients with BRAF-mutant melanoma receiving encorafenib plus binimetinib versus vemurafenib or encorafenib (COLUMBUS) : A multicentre, open-label, randomised, phase 3 trial

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Differential impact of pure glyphosate and glyphosate-based herbicide in a model of peripheral nervous system myelination

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Translational Insights into Gastrointestinal Stromal Tumor and Current Clinical Advances

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A mechanistic classification of clinical phenotypes in neuroblastoma

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Sebaceous tumours: more than skin deep

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Soft tissue and visceral sarcomas : ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

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B Cell-Mediated Maintenance of Cluster of Differentiation 169–Positive Cells Is Critical for Liver Regeneration

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Estimate of long-term relapse-free survival (RFS) and analysis of baseline factors associated with RFS in the COMBI-AD trial

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Consensus on molecular imaging and theranostics in prostate cancer

In: The Lancet Oncology Vol. 19 (2018) Nr. 12, pp. e696 - e708

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NAPOLI-1 phase III trial outcomes by prior surgery, and disease stage, in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC)

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Imaging of coronary inflammation for cardiovascular risk prediction

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Impact of dose reduction or dose delay on the efficacy of liposomal irinotecan (nal-IRI)+5-fluorouracil/leucovorin (5-FU/LV) : Survival analysis from NAPOLI-1

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Circulating cell-free miR-375 as surrogate marker of tumor burden in Merkel cell carcinoma

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A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

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Consensus statement on mandatory measurements in pancreatic cancer trials (COMM-PACT) for systemic treatment of unresectable disease

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CEACAM1 promotes CD8⁺ T cell responses and improves control of a chronic viral infection

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An oncogenic axis of STAT-mediated BATF3 upregulation causing MYC activity in classical Hodgkin lymphoma and anaplastic large cell lymphoma

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Clinical Relevance and Suppressive Capacity of Human Myeloid-Derived Suppressor Cell Subsets

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Development and Validation of a Gene Signature for Patients with Head and Neck Carcinomas Treated by Postoperative Radio(chemo)therapy

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DNA methylation-based classification of central nervous system tumours

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PD-1 blockade with cemiplimab in advanced cutaneous squamous-cell carcinoma

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Correction: Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa

In: Molecular Psychiatry Vol. 23 (2018) Nr. 9, pp. 1

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Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade

In: Cell Vol. 173 (2018) Nr. 3, pp. 624 - 633.e8

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Biased IGH VDJ gene repertoire and clonal expansions in B cells of chronically hepatitis C virus–infected individuals

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IG-MYC⁺ neoplasms with precursor B-cell phenotype are molecularly distinct from Burkitt lymphomas

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Nivolumab plus ipilimumab or nivolumab alone versus ipilimumab alone in advanced melanoma (CheckMate 067) : 4-year outcomes of a multicentre, randomised, phase 3 trial

In: The Lancet Oncology Vol. 19 (2018) Nr. 11, pp. 1480 - 1492

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Encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF-mutant melanoma (COLUMBUS) : a multicentre, open-label, randomised phase 3 trial

In: The Lancet Oncology Vol. 19 (2018) Nr. 5, pp. 603 - 615

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T cell receptor fingerprinting enables in-depth characterization of the interactions governing recognition of peptide–MHC complexes

In: Nature Biotechnology Vol. 36 (2018) Nr. 12, pp. 1191 - 1196

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Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors

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Helicobacter pylori adhesin HopQ disrupts trans dimerization in human CEACAMs

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Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa

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Hepatitis B virus sensitivity to interferon-α in hepatocytes is more associated with cellular interferon response than with viral genotype

In: Hepatology Vol. 67 (2018) Nr. 4, pp. 1237 - 1252

Online Full Text: dx.doi.org/ (Open Access)
Gröbner, Susanne N.; Worst, Barbara C.; Weischenfeldt, Joachim; Buchhalter, Ivo; Kleinheinz, Kortine; Rudneva, Vasilisa A.; Johann, Pascal D.; Balasubramanian, Gnana Prakash; Segura-Wang, Maia; Brabetz, Sebastian; Bender, Sebastian; Hutter, Barbara; Sturm, Dominik; Pfaff, Elke; Hübschmann, Daniel; Zipprich, Gideon; Heinold, Michael; Eils, Jürgen; Lawerenz, Christian; Erkek, Serap; Lambo, Sander; Waszak, Sebastian; Blattmann, Claudia; Borkhardt, Arndt; Kuhlen, Michaela; Eggert, Angelika; Fulda, Simone; Gessler, Manfred; Wegert, Jenny; Kappler, Roland; Baumhoer, Daniel; Burdach, Stefan; Kirschner-Schwabe, Renate; Kontny, Udo; Kulozik, Andreas E.; Lohmann, Dietmar; Hettmer, Simone; Eckert, Cornelia; Bielack, Stefan; Nathrath, Michaela; Niemeyer, Charlotte; Richter, Günther H.; Schulte, Johannes; Siebert, Reiner; Westermann, Frank; Molenaar, Jan J.; Vassal, Gilles; Witt, Hendrik; Zapatka, Marc; Burkhardt, Birgit; Kratz, Christian P.; Witt, Olaf; Tilburg, Cornelis M. Van; Kramm, Christof M.; Fleischhack, Gudrun; Dirksen, Uta; Rutkowski, Stefan; Frühwald, Michael; Hoff, Katja Von; Wolf, Stephan; Klingebiel, Thomas; Koscielniak, Ewa; Landgraf, Pablo; Koster, Jan; Resnick, Adam C.; Zhang, Jinghui; Liu, Yanling; Zhou, Xin; Waanders, Angela J.; Zwijnenburg, Danny A.; Raman, Pichai; Brors, Benedikt; Weber, Ursula D.; Northcott, Paul A.; Pajtler, Kristian; Kool, Marcel; Piro, Rosario M.; Korbel, Jan O.; Schlesner, Matthias; Eils, Roland; Jones, David T. W.; Lichter, Peter; Chavez, Lukas; Pfister, Stefan M.

The landscape of genomic alterations across childhood cancers

In: Nature Vol. 555 (2018) Nr. 7696, pp. 321 - 327

Online Full Text: dx.doi.org/ (Open Access)
Küppers, Ralf; Stevenson, Freda K.

Critical influences on the pathogenesis of follicular lymphoma

In: Blood Vol. 131 (2018) Nr. 21, pp. 2297 - 2306

Online Full Text: dx.doi.org/ (Open Access)
Becker-Flegler, Katrin; Riethmüller, Joachim; Seitz, Aaron P.; Gardner, Aaron; Boudreau, Ryan; Kamler, Markus; Kleuser, Burkhard; Schuchman, Edward; Caldwell, Charles C.; Edwards, Michael J.; Grassmé, Heike; Brodlie, Malcolm; Gulbins, Erich

Sphingolipids as targets for inhalation treatment of cystic fibrosis

In: Advanced Drug Delivery Reviews Vol. 133 (2018) pp. 66 - 75

Online Full Text: dx.doi.org/
van Dinther, Dieke; Veninga, Henrike; Iborra, Salvador; Borg, Ellen G.F.; Hoogterp, Leoni; Olesek, Katarzyna; Beijer, Marieke R.; Schetters, Sjoerd T.T.; Kalay, Hakan; Garcia-Vallejo, Juan J.; Franken, Kees L.; Cham, Lamin B.; Lang, Karl S.; van Kooyk, Yvette; Sancho, David; Crocker, Paul R.; den Haan, Joke M.M.

Functional CD169 on Macrophages Mediates Interaction with Dendritic Cells for CD8+ T Cell Cross-Priming

In: Cell Reports Vol. 22 (2018) Nr. 6, pp. 1484 - 1495

Online Full Text: dx.doi.org/ (Open Access)
Chudasama, Priya; Mughal, Sadaf S.; Schröck, Evelin; Glimm, Hanno; Kleinheinz, Kortine; Klink, Barbara; Brors, Benedikt; Hlevnjak, Mario; Gröschel, Stefan; Wolf, Stephan; Omlor, Georg; Ernst, Aurélie; Ulrich, Alexis; Deeg, Katharina I.; Mechtersheimer, Gunhild; Schimmack, Simon; Eils, Roland; Egerer, Gerlinde; Kasper, Bernd; Wong, Siao-Han; von Kalle, Christof; Hohenberger, Peter; Lehner, Burkhard; Rippe, Karsten; Chung, Inn; Bauer, Sebastian; Scholl, Claudia; Sieverling, Lina; Sanders, Mathijs A.; Hübschmann, Daniel; Heilig, Christoph E.; Hutter, Barbara; Renner, Marcus; Weichert, Wilko; Stenzinger, Albrecht; Schlesner, Matthias; Hoogenboezem, Remco M.; Kopp, Hans-Georg; Rabe, Sophie; Zapatka, Marc; Fröhling, Stefan

Integrative genomic and transcriptomic analysis of leiomyosarcoma

In: Nature Communications Vol. 9 (2018) Nr. 1, pp. 144

Online Full Text: dx.doi.org/ (Open Access)
Bezrookove, Vladimir; Nosrati, Mehdi; Miller, James R.; De Semir, David; Dar, Altaf A.; Vosoughi, Elham; Vaquero, Edith; Sucker, Antje; Lazar, Alexander J.; Gershenwald, Jeffrey E.; Davies, Michael A.; Schadendorf, Dirk; Kashani-Sabet, Mohammed

Role of elevated PHIP copy number as a prognostic and progression marker for cutaneous melanoma

In: Clinical Cancer Research Vol. 24 (2018) Nr. 17, pp. 4119 - 4125

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Lecouvet, Frédéric E.; Oprea-Lager, Daniela E.; Liu, Yan; Ost, Piet; Bidaut, Luc; Collette, Laurence; Deroose, Christophe M.; Goffin, Karolien; Herrmann, Ken; Hoekstra, Otto S.; Kramer, Gem; Lievens, Yolande; Lopci, Egesta; Pasquier, David; Petersen, Lars J.; Talbot, Jean-Noël; Zacho, Helle; Tombal, Bertrand; deSouza, Nandita M.

Use of modern imaging methods to facilitate trials of metastasis-directed therapy for oligometastatic disease in prostate cancer : a consensus recommendation from the EORTC Imaging Group

In: The Lancet Oncology Vol. 19 (2018) Nr. 10, pp. e534 - e545

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Casali, P.G.; Abecassis, N.; Bauer, Sebastian; Biagini, R.; Bielack, S.; Bonvalot, S.; Boukovinas, I.; Bovee, J.V.M.G.; Brodowicz, T.; Broto, J.M.; Buonadonna, A.; De Álava, E.; Dei Tos, A.P.; Del Muro, X.G.; Dileo, P.; Eriksson, M.; Fedenko, A.; Ferraresi, V.; Ferrari, A.; Ferrari, S.; Frezza, A.M.; Gasperoni, S.; Gelderblom, H.; Gil, T.; Grignani, G.; Gronchi, A.; Haas, R.L.; Hannu, A.; Hassan, B.; Hohenberger, P.; Issels, R.; Joensuu, H.; Jones, R.L.; Judson, I.; Jutte, P.; Kaal, S.; Kasper, B.; Kopeckova, K.; Krákorová, D.A.; Le Cesne, A.; Lugowska, I.; Merimsky, O.; Montemurro, M.; Pantaleo, M.A.; Piana, R.; Picci, P.; Piperno-Neumann, S.; Pousa, A.L.; Reichardt, P.; Robinson, M.H.; Rutkowski, P.; Safwat, A.A.; Schöffski, P.; Sleijfer, S.; Stacchiotti, S.; Sundby Hall, K.; Unk, M.; Van Coevorden, F.; Van Der Graaf, W.; Whelan, J.; Wardelmann, E.; Zaikova, O.; Blay, J.Y.

Gastrointestinal stromal tumours: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 4, pp. iv68 - iv78

Online Full Text: dx.doi.org/ (Open Access)
Cheung, Phyllis F.; Neff, Florian; Neander, Christian; Bazarna, Anna; Savvatakis, Konstantinos; Liffers, Sven-Thorsten; Althoff, Kristina; Lee, Chang-Lung; Moding, Everett J.; Kirsch, David G.; Saur, Dieter; Bazhin, Alexandr V.; Trajkovic-Arsic, Marija; Heikenwalder, Mathias F.; Siveke, Jens

Notch-induced myeloid reprogramming in spontaneous pancreatic ductal adenocarcinoma by dual genetic targeting

In: Cancer Research Vol. 78 (2018) Nr. 17, pp. 4997 - 5010

Online Full Text: dx.doi.org/ (Open Access)
Griewank, Klaus G.; Koelsche, Christian; van de Nes, Johannes A. P.; Schrimpf, Daniel; Gessi, Marco; Möller, Inga; Sucker, Antje; Scolyer, Richard A.; Buckland, Michael E.; Murali, Rajmohan; Pietsch, Torsten; Deimling, Andreas von; Schadendorf, Dirk

Integrated genomic classification of melanocytic tumors of the central nervous system using mutation analysis, copy number alterations, and DNA methylation profiling

In: Clinical Cancer Research Vol. 24 (2018) Nr. 18, pp. 4494 - 4504

Online Full Text: dx.doi.org/ (Open Access)

ZMB Site - Medical Faculty / University Hospital Essen

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