ZMB Member Heike Heuer

ZMB Member
Heike Heuer

Next ZMB-Member
Heike Heuer portrait
© UKE/Heuer

Prof. Dr. Heike Heuer

Group

Molecular Thyroidology

Clinic for Endocrinology, Diabetes & Metabolism
University Hospital Essen
Hufelandstr. 55
45122 Essen

Research Overview

  • Defining the cell-specific role of thyroid hormone transporters in health and disease
  • Development of therapeutic strategies for patients with Allan-Herndon-Dudley Syndrome (AHDS)
  • Endocrine disruptors affecting thyroid hormone transport
  • Molecular mechanismen of thyroid hormone action in brain development

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Publications

    Journal articles

  • Chen, Zhongli; Yildiz, Sena; Markova, Boyka; de Rooij, Linda J.; Leeuwenburgh, Selmar; Hamers, Timo; Peeters, Robin P.; Heuer, Heike; Meima, Marcel E.; Visser, W. Edward
    3,3′,5-Triiodothyroacetic Acid Transporters
    In: Thyroid (2024) in press
    Online Full Text: dx.doi.org/
  • Liu, Ye; Ng, Lily; Liu, Hong; Heuer, Heike; Forrest, Douglas
    Cone photoreceptor differentiation regulated by thyroid hormone transporter MCT8 in the retinal pigment epithelium
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 121 (2024) Nr. 30, e2402560121
    Online Full Text: dx.doi.org/
  • Venugopalan, Vaishnavi; Rehders, Maren; Weber, Jonas; Rodermund, Lisa; Al-Hashimi, Alaa; Bargmann, Tonia; Golchert, Janine; Reinecke, Vivien; Homuth, Georg; Völker, Uwe; Verrey, Francois; Kirstein, Janine; Heuer, Heike; Schweizer, Ulrich; Braun, Doreen; Wirth, Eva K.; Brix, Klaudia
    Lack of L-type amino acid transporter 2 in murine thyroid tissue induces autophagy
    In: Journal of Molecular Endocrinology Vol. 70 (2023) Nr. 1, e220060
    Online Full Text: dx.doi.org/
  • Siemes, Devon; Vancamp, Pieter; Markova, Boyka; Spangenberg, Philippa; Shevchuk, Olga; Siebels, Bente; Schlüter, Hartmut; Mayerl, Steffen; Heuer, Heike; Engel, Daniel Robert
    Proteome Analysis of Thyroid Hormone Transporter Mct8/Oatp1c1-Deficient Mice Reveals Novel Dysregulated Target Molecules Involved in Locomotor Function
    In: Cells Vol. 12 (2023) Nr. 20, 2487
    Online Full Text: dx.doi.org/ (Open Access)
  • Ullrich, Simon; Leidescher, Susanne; Feodorova, Yana; Thanisch, Katharina; Fini, Jean-Baptiste; Kaspers, Bernd; Weber, Frank; Markova, Boyka; Führer, Dagmar; Romitti, Mirian; Krebs, Stefan; Blum, Helmut; Leonhardt, Heinrich; Costagliola, Sabine; Heuer, Heike; Solovei, Irina
    The highly and perpetually upregulated thyroglobulin gene is a hallmark of functional thyrocytes
    In: Frontiers in Cell and Developmental Biology Vol. 11 (2023) 1265407
    Online Full Text: dx.doi.org/ (Open Access)
  • Mayerl, Steffen; Heuer, Heike
    Thyroid hormone transporter Mct8/Oatp1c1 deficiency compromises proper oligodendrocyte maturation in the mouse CNS
    In: Neurobiology of Disease Vol. 184 (2023) 106195
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Chen, Jiesi; Salveridou, Eva; Liebmann, Lutz; Sundaram, Sivaraj M.; Doycheva, Denica; Markova, Boyka; Hübner, Christian A.; Boelen, Anita; Visser, W. Edward; Heuer, Heike; Mayerl, Steffen
    Triac Treatment Prevents Neurodevelopmental and Locomotor Impairments in Thyroid Hormone Transporter Mct8/Oatp1c1 Deficient Mice
    In: International Journal of Molecular Sciences (IJMS) Vol. 24 (2023) Nr. 4, 3452
    Online Full Text: dx.doi.org/ (Open Access)
  • Liao, Xiao-Hui; Avalos, Pablo; Shelest, Oksana; Ofan, Raz; Shilo, Michael; Bresee, Catherine; Likhite, Shibi; Vit, Jean-Philippe; Heuer, Heike; Kaspar, Brian; Meyer, Kathrin; Dumitrescu, Alexandra M.; Refetoff, Samuel; Svendsen, Clive N.; Vatine, Gad D.
    AAV9-MCT8 Delivery at Juvenile Stage Ameliorates Neurological and Behavioral Deficits in a Mouse Model of MCT8-Deficiency
    In: Thyroid Vol. 32 (2022) Nr. 7, pp. 849 - 859
    Online Full Text: dx.doi.org/ (Open Access)
  • Hu, Yalan; Lauffer, Peter; Stewart, Michelle; Codner, Gemma; Mayerl, Steffen; Heuer, Heike; Ng, Lily; Forrest, Douglas; van Trotsenburg, Paul; Jongejan, Aldo; Fliers, Eric; Hennekam, Raoul; Boelen, Anita
    An animal model for Pierpont syndrome : A mouse bearing the Tbl1xr1 (Y446C/Y446C) mutation
    In: Human Molecular Genetics Vol. 31 (2022) Nr. 17, pp. 2951 - 2963
    Online Full Text: dx.doi.org/ (Open Access)
  • Mayerl, Steffen; Alcaide Martin, Andrea; Bauer, Reinhard; Schwaninger, Markus; Heuer, Heike; ffrench-Constant, Charles
    Distinct Actions of the Thyroid Hormone Transporters Mct8 and Oatp1c1 in Murine Adult Hippocampal Neurogenesis
    In: Cells Vol. 11 (2022) Nr. 3, 524
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Groeneweg, Stefan; van Geest, Ferdy S.; Chen, Zhongli; Farina, Stefania; van Heerebeek, Ramona E.A.; Meima, Marcel E.; Peeters, Robin P.; Heuer, Heike; Medici, Marco; Visser, W. Edward
    Functional Characterization of the Novel and Specific Thyroid Hormone Transporter SLC17A4
    In: Thyroid Vol. 32 (2022) Nr. 3, pp. 326 - 335
    Online Full Text: dx.doi.org/
  • Sundaram, Sivaraj M.; Arrulo Pereira, Adriana; Müller-Fielitz, Helge; Köpke, Hannes; De Angelis, Meri; Müller, Timo D.; Heuer, Heike; Körbelin, Jakob; Krohn, Markus; Mittag, Jens; Nogueiras, Ruben; Prevot, Vincent; Schwaninger, Markus
    Gene therapy targeting the blood–brain barrier improves neurological symptoms in a model of genetic MCT8 deficiency
    In: Brain: A Journal of Neurology Vol. 145 (2022) Nr. 12, pp. 4264 - 4274
    Online Full Text: dx.doi.org/ (Open Access)
  • Reinwald, Jonathan Rochus; Weber-Fahr, Wolfgang; Cosa-Linan, Alejandro; Becker, Robert; Sack, Markus; Falfan-Melgoza, Claudia; Gass, Natalia; Braun, Urs; Clemm von Hohenberg, Christian; Chen, Jiesi; Mayerl, Steffen; Muente, Thomas F.; Heuer, Heike; Sartorius, Alexander
    TRIAC Treatment Improves Impaired Brain Network Function and White Matter Loss in Thyroid Hormone Transporter Mct8/Oatp1c1 Deficient Mice
    In: International Journal of Molecular Sciences (IJMS) Vol. 23 (2022) Nr. 24, 15547
    Online Full Text: dx.doi.org/ (Open Access)
  • Lademann, Franziska; Mayerl, Steffen; Tsourdi, Elena; Verrey, Francois; Leitch, Victoria D.; Williams, Graham R.; Bassett, J. H. Duncan; Hofbauer, Lorenz C.; Heuer, Heike; Rauner, Martina
    The Thyroid Hormone Transporter MCT10 Is a Novel Regulator of Trabecular Bone Mass and Bone Turnover in Male Mice
    In: Endocrinology Vol. 163 (2022) Nr. 1, bqab218
    Online Full Text: dx.doi.org/ (Open Access)
  • Mayerl, Steffen; Chen, Jiesi; Salveridou, Eva; Boelen, Anita; Darras, Veerle M; Heuer, Heike
    Thyroid Hormone Transporter Deficiency in Mice Impacts Multiple Stages of GABAergic Interneuron Development
    In: Cerebral Cortex Vol. 32 (2022) Nr. 2, pp. 329 - 341
    Online Full Text: dx.doi.org/ (Open Access)
  • Luongo, Cristina; Butruille, Lucile; Sébillot, Anthony; Le Blay, Karine; Schwaninger, Markus; Heuer, Heike; Demeneix, Barbara A.; Remaud, Sylvie
    Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone
    In: Stem Cell Reports Vol. 16 (2021) Nr. 2, pp. 337 - 353
    Online Full Text: dx.doi.org/ (Open Access)
  • Morte, Beatriz; Gil-Ibañez, Pilar; Heuer, Heike; Bernal, Juan
    Brain gene expression in systemic hypothyroidism and mouse models of MCT8 deficiency : The Mct8-Oatp1c1-Dio2 triad
    In: Thyroid Vol. 31 (2021) Nr. 6, pp. 985 - 993
    Online Full Text: dx.doi.org/ (Open Access)
  • Jonklaas, Jacqueline; Bianco, Antonio C.; Cappola, Anne R.; Celi, Francesco S.; Fliers, Eric; Heuer, Heike; McAninch, Elizabeth A.; Möller, Lars; Nygaard, Birte; Sawka, Anna M.; Watt, Torquil; Dayan, Colin M.
    Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism : A Consensus Document
    In: Thyroid Vol. 31 (2021) Nr. 2, pp. 156 - 182
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Jonklaas, Jacqueline; Bianco, Antonio C.; Cappola, Anne R.; Celi, Francesco S.; Fliers, Eric; Heuer, Heike; McAninch, Elizabeth A.; Möller, Lars; Nygaard, Birte; Sawka, Anna M.; Watt, Torquil; Dayan, Colin M.
    Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document
    In: European Thyroid Journal Vol. 10 (2021) Nr. 1, pp. 10 - 38
    Online Full Text: dx.doi.org/ (Open Access)
  • Kowallick, Mirjam; Serdar, Meray; Markova, Boyka; Salveridou, Eva; Felderhoff-Müser, Ursula; Führer-Sakel, Dagmar; Heuer, Heike; Bendix, Ivo; Dewan, Monia Vanessa
    Hyperoxia Leads to Transient Endocrine Alterations in the Neonatal Rat During Postnatal Development
    In: Frontiers in Pediatrics Vol. 9 (2021) 723928
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Vatine, Gad D.; Shelest, Oksana; Barriga, Bianca K.; Ofan, Raz; Rabinski, Tatyana; Mattis, Virginia B.; Heuer, Heike; Svendsen, Clive N.
    Oligodendrocyte progenitor cell maturation is dependent on dual function of MCT8 in the transport of thyroid hormone across brain barriers and the plasma membrane
    In: Glia Vol. 69 (2021) Nr. 9, pp. 2146 - 2159
    Online Full Text: dx.doi.org/
  • Shukla, Shalmali; Haenold, Ronny; Urbánek, Pavel; Frappart, Lucien; Monajembashi, Shamci; Grigaravicius, Paulius; Nagel, Sigrun; Min, Woo Kee; Tapias, Alicia; Kassel, Olivier; Heuer, Heike; Wang, Zhao-Qi; Ploubidou, Aspasia; Herrlich, Peter
    TRIP6 functions in brain ciliogenesis
    In: Nature Communications Vol. 12 (2021) Nr. 1, 5887
    Online Full Text: dx.doi.org/ (Open Access)
  • Venugopalan, Vaishnavi; Al-Hashimi, Alaa; Weber, Jonas; Rehders, Maren; Qatato, Maria; Wirth, Eva K.; Schweizer, Ulrich; Heuer, Heike; Verrey, François; Brix, Klaudia
    The amino acid transporter mct10/tat1 is important to maintain the tsh receptor at its canonical basolateral localization and assures regular turnover of thyroid follicle cells in male mice
    In: International Journal of Molecular Sciences (IJMS) Vol. 22 (2021) Nr. 11, 5776
    Online Full Text: dx.doi.org/ (Open Access)
  • Venugopalan, Vaishnavi; Al-Hashimi, Alaa; Rehders, Maren; Golchert, Janine; Reinecke, Vivien; Homuth, Georg; Völker, Uwe; Manirajah, Mythili; Touzani, Adam; Weber, Jonas; Bogyo, Matthew S.; Verrey, Francois; Wirth, Eva K.; Schweizer, Ulrich; Heuer, Heike; Kirstein, Janine; Brix, Klaudia
    The thyroid hormone transporter MCT8 restricts cathepsin-mediated thyroglobulin processing in male mice through thyroid auto-regulatory mechanisms that encompass autophagy
    In: International Journal of Molecular Sciences (IJMS) Vol. 22 (2021) Nr. 1, pp. 462
    Online Full Text: dx.doi.org/ (Open Access)
  • Herrmann, Beate; Harder, Lisbeth; Oelkrug, Rebecca; Chen, Jiesi; Gachkar, Sogol; Nock, Sebastian; Resch, Julia; Korkowski, Markus; Heuer, Heike; Mittag, Jens
    Central Hypothyroidism Impairs Heart Rate Stability and Prevents Thyroid Hormone-Induced Cardiac Hypertrophy and Pyrexia
    In: Thyroid Vol. 30 (2020) Nr. 8, pp. 1205 - 1216
    Online Full Text: dx.doi.org/
  • Mayerl, Steffen; Heuer, Heike; Ffrench-Constant, Charles
    Hippocampal Neurogenesis Requires Cell-Autonomous Thyroid Hormone Signaling
    In: Stem Cell Reports Vol. 14 (2020) Nr. 5, pp. 845 - 860
    Online Full Text: dx.doi.org/ (Open Access)
  • Lademann, Franziska; Tsourdi, Elena; Rijntjes, Eddy; Köhrle, Josef; Hofbauer, Lorenz C.; Heuer, Heike; Rauner, Martina
    Lack of the Thyroid Hormone Transporter Mct8 in Osteoblast and Osteoclast Progenitors Increases Trabecular Bone in Male Mice
    In: Thyroid Vol. 30 (2020) Nr. 2, pp. 329 - 342
    Online Full Text: dx.doi.org/
  • Bottek, Jenny; Soun, Camille; Lill, Julia K.; Dixit, Akanksha; Thiebes, Stephanie; Beerlage, Anna-Lena; Horstmann, Marius; Urbanek, Annett; Heuer, Heike; Uszkoreit, Julian; Eisenacher, Martin; Bracht, Thilo; Sitek, Barbara; Hoffmann, Franziska; Vijitha, Nirojah; von Eggeling, Ferdinand; Engel, Daniel Robert
    Spatial proteomics revealed a CX₃CL1-dependent crosstalk between the urothelium and relocated macrophages through IL-6 during an acute bacterial infection in the urinary bladder
    In: Mucosal Immunology Vol. 13 (2020) Nr. 4, pp. 702 - 714
    Online Full Text: dx.doi.org/ (Open Access)
  • Groeneweg, Stefan; van Geest, Ferdy S.; Peeters, Robin P.; Heuer, Heike; Visser, W. Edward
    Thyroid Hormone Transporters
    In: Endocrine Reviews Vol. 41 (2020) Nr. 2, pp. 146 - 201
    Online Full Text: dx.doi.org/ (Open Access)
  • Salveridou, Eva; Mayerl, Steffen; Sundaram, Sivaraj Mohana; Markova, Boyka; Heuer, Heike
    Tissue-Specific Function of Thyroid Hormone Transporters : New Insights from Mouse Models
    In: Experimental and Clinical Endocrinology & Diabetes Vol. 128 (2020) Nr. 6-7, pp. 423 - 437
    Online Full Text: dx.doi.org/
  • Kerp, Helena; Engels, Kathrin; Kramer, Frederike; Doycheva, Denica; Sebastian Hönes, Georg; Zwanziger, Denise; Christian Moeller, Lars; Heuer, Heike; Führer, Dagmar
    Age effect on thyroid hormone brain response in male mice
    In: Endocrine Vol. 66 (2019) Nr. 3, pp. 596 - 606
    Online Full Text: dx.doi.org/
  • Walter, Kyla M.; Dach, Katharina; Hayakawa, Keri; Giersiefer, Susanne; Heuer, Heike; Lein, Pamela J.; Fritsche, Ellen
    Ontogenetic expression of thyroid hormone signaling genes : An in vitro and in vivo species comparison
    In: PLoS ONE Vol. 14 (2019) Nr. 9, pp. 0221230
    Online Full Text: dx.doi.org/ (Open Access)
  • Sharlin, David S; Ng, Lily; Verrey, François; Visser, Theo J; Liu, Ye; Olszewski, Rafal T; Hoa, Michael; Heuer, Heike; Forrest, Douglas
    Deafness and loss of cochlear hair cells in the absence of thyroid hormone transporters Slc16a2 (Mct8) and Slc16a10 (Mct10).
    In: Scientific Reports Vol. 8 (2018) Nr. 1, pp. 4403
    Online Full Text: dx.doi.org/ (Open Access)
  • Harder, L; Dudazy-Gralla, S; Müller-Fielitz, H; Hjerling Leffler, J; Vennström, B; Heuer, Heike; Mittag, J
    Maternal thyroid hormone is required for parvalbumin neurone development in the anterior hypothalamic area
    In: Journal of Neuroendocrinology Vol. 30 (2018) Nr. 3, pp. e12573
    Online Full Text: dx.doi.org/ (Open Access)
  • Strømme, Petter; Groeneweg, Stefan; Lima de Souza, Elaine C.; Zevenbergen, Chantal; Torgersbråten, Anette; Holmgren, Asbjørn; Gurcan, Ebrar; Meima, Marcel E.; Peeters, Robin P.; Visser, W Edward; Høneren Johansson, Linda; Babovic, Almira; Zetterberg, Henrik; Heuer, Heike; Frengen, Eirik; Misceo, Doriana; Visser, Theo J.
    Mutated Thyroid Hormone Transporter OATP1C1 Associates with Severe Brain Hypometabolism and Juvenile Neurodegeneration
    In: Thyroid Vol. 28 (2018) Nr. 11, pp. 1406 - 1415
    Online Full Text: dx.doi.org/ (Open Access)
  • Mayerl, Steffen; Schmidt, Manuel; Doycheva, Denica; Darras, Veerle M.; Hüttner, Sören S.; Boelen, Anita; Visser, Theo J.; Kaether, Christoph; Heuer, Heike; von Maltzahn, Julia
    Thyroid Hormone Transporters MCT8 and OATP1C1 Control Skeletal Muscle Regeneration
    In: Stem Cell Reports Vol. 10 (2018) Nr. 6, pp. 1959 - 1974
    Online Full Text: dx.doi.org/ (Open Access)