Scientists of this strategic research area are currently coordinating 7 joint research projects of the German Research Foundation DFG:

SFB/TRR 332: Neutrophil granulocytes: origin, fate and function

The most current Collaborative Research Centre TRR332 is a DFG-funded consortium dedicated to develop an improved understanding of neutrophil biology. Studies will reveal mechanisms of how the tissue environment regulates neutrophil production and phenotypes, how neutrophil activity is controlled intracellularly and how neutrophils function in different disease contexts. Five sub-projects are running at the UDE, spokesman in Essen is Prof. Dr. Matthias Gunzer.

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CRC 1430: Molecular Mechanisms on Cell State Transitions

The Collaborative Research Center 1430, established in May 2021, aims to understand how the interplay between molecular signals and the regulatory switches works, which together trigger the transitions between defined cell states. This interplay, which is as yet poorly understood, is crucial for cell growth and division, but also for the development and treatability of cancer. The researchers hope to gain new insights that will open up new treatment options.
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KFO 337: Phenotypic Therapy and Immune Escape in Cancer (PhenoTImE)

Since 2019, scientists in the clinical research group KFO 337 have been developing new concepts on the plasticity of malignant melanomas and tumors of the brain and pancreas. Furthermore, they investigate the development of therapy resistance and explore the underlying mechanisms. The aim is also to exchange approaches and methods and to find solid preclinical evidence for future therapy improvements.
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SFB/TRR 296: Local control of TH action (LocoTact)

Local mechanisms of thyroid hormone action in the target organ systems brain, heart and liver, which are the starting point of common diseases such as stroke, myocardial infarction, heart failure or liver inflammation, have been the focus of the SFB/TRR 296 since 2020. The researchers use new techniques to modulate the hormones in the human context with organoids. The aim of their investigations is to understand the disease processes in more detail and to evaluate potential therapeutic effects of targeted modulation of hormone status in local tissues.
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FOR 2974: Affective and cognitive mechanisms of specific Internet-use disorders (ACSID)

Since 2020 the overarching goal of the FOR 2974 research group is to understand common and distinct psychological and neurobiological processes that underlie primarily online, uncontrolled, and addictive behaviors such as computer gaming, pornography use, shopping, and social network use.
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SFB 1280: Extinction Learning

Since 2017, the SFB 1280 has been investigating the neural, behavioral, educational, ontogenetic and clinical mechanisms of extinction learning in different species, including humans, using different research approaches. The goal of analyzing common and distinct mechanisms of extinction learning in different systems and organisms is to establish translational insights between basic research and clinical as well as social sciences.
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CRC/TRR 289: Treatment Expectation

Gaining insights for a systematic application of expectancy effects in the context of medical treatments is the goal of the cross-university CRC/TRR 289. Using clinically relevant diseases such as pain disorders and affective disorders and with corresponding experimental models, the psychological and neurobiological mechanisms of positive and negative treatment expectations and their influence on pharmacological treatments are investigated.
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