ZMB Member Josephine Herz

ZMB Member
Josephine Herz

Next ZMB-Member
Josephine Herz portrait
© UKE

PD Dr. Josephine Herz

Pediatrics Clinic I
University Hospital Essen
Hufelandstr. 55
45122 Essen

Research Overview

The questions of the experimental perinatal neurosciences are aimed at uncovering cellular and molecular mechanisms of typical diseases of premature babies and sick newborns, with the integrity of the central nervous system being the focus of research.

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Publications

    Journal articles

  • Toh, Wei Seong; Yarani, Reza; El Andaloussi, Samir; Cho, Byong Seung; Choi, Chulhee; Corteling, Randolph; De Fougerolles, Antonin; Gimona, Mario; Herz, Josephine; Khoury, Maroun; Robbins, Paul D.; Williams, Douglas; Weiss, Daniel J.; Rohde, Eva; Giebel, Bernd; Lim, Sai Kiang
    A report on the International Society for Cell & Gene Therapy 2022 Scientific Signature Series, “Therapeutic advances with native and engineered human extracellular vesicles”
    In: Cytotherapy Vol. 25 (2023) Nr. 8, pp. 810 - 814
  • Labusek, Nicole; Mouloud, Yanis; Köster, Christian; Diesterbeck, Eva; Tertel, Tobias; Wiek, Constanze; Hanenberg, Helmut; Horn, Peter; Felderhoff-Müser, Ursula; Bendix, Ivo; Giebel, Bernd; Herz, Josephine
    Extracellular vesicles from immortalized mesenchymal stromal cells protect against neonatal hypoxic-ischemic brain injury
    In: Inflammation and Regeneration Vol. 43 (2023) Nr. 1, 24
  • Labusek, Nicole; Ghari, Parnian; Mouloud, Yanis; Köster, Christian; Diesterbeck, Eva; Hadamitzky, Martin; Felderhoff-Müser, Ursula; Bendix, Ivo; Giebel, Bernd; Herz, Josephine
    Hypothermia combined with extracellular vesicles from clonally expanded immortalized mesenchymal stromal cells improves neurodevelopmental impairment in neonatal hypoxic-ischemic brain injury
    In: Journal of Neuroinflammation Vol. 20 (2023) Nr. 1, 280
  • Abberger, Hanna; Hose, Matthias; Ninnemann, Anne; Menne, Christopher; Eilbrecht, Mareike; Lang, Karl S.; Matuschewski, Kai; Geffers, Robert; Herz, Josephine; Buer, Jan; Westendorf, Astrid; Hansen, Wiebke
    Neuropilin-1 identifies a subset of highly activated CD8⁺ T cells during parasitic and viral infections
    In: PLoS Pathogens Vol. 19 (2023) Nr. 11, e1011837
  • Obst, Stefanie; Herz, Josephine; Alejandre Alcazar, Miguel A.; Endesfelder, Stefanie; Möbius, Marius A.; Rüdiger, Mario; Felderhoff-Müser, Ursula; Bendix, Ivo
    Perinatal Hyperoxia and Developmental Consequences on the Lung-Brain Axis
    In: Oxidative Medicine and Cellular Longevity (2022) 5784146
  • Herz, Josephine; Bendix, Ivo; Felderhoff-Müser, Ursula
    Peripheral immune cells and perinatal brain injury : A double-edged sword?
    In: Pediatric Research Vol. 91 (2022) Nr. 2, pp. 392 - 403
  • Wang, Chen; Börger, Verena; Mohamud Yusuf, Ayan; Tertel, Tobias; Stambouli, Oumaima; Murke, Florian; Freund, Nico; Kleinschnitz, Christoph; Herz, Josephine; Gunzer, Matthias; Popa-Wagner, Aurel; Döppner, Thorsten R.; Giebel, Bernd; Hermann, Dirk M.
    Postischemic Neuroprotection Associated With Anti-Inflammatory Effects by Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles in Aged Mice
    In: Stroke Vol. 53 (2022) Nr. 1, pp. E14 - E18
  • Beckmann, Lucia; Obst, Stefanie; Labusek, Nicole; Abberger, Hanna; Köster, Christian; Klein-Hitpaß, Ludger; Schumann, Sven; Kleinschnitz, Christoph; Hermann, Dirk M.; Felderhoff-Müser, Ursula; Bendix, Ivo; Hansen, Wiebke; Herz, Josephine
    Regulatory T Cells Contribute to Sexual Dimorphism in Neonatal Hypoxic-Ischemic Brain Injury
    In: Stroke Vol. 53 (2022) Nr. 2, pp. 381 - 390
  • Seitz, Marina; Köster, Christian; Dzietko, Mark; Sabir, Hemmen; Serdar, Meray; Felderhoff-Müser, Ursula; Bendix, Ivo; Herz, Josephine
    Hypothermia modulates myeloid cell polarization in neonatal hypoxic–ischemic brain injury
    In: Journal of Neuroinflammation Vol. 18 (2021) Nr. 1, 266
  • Mülling, Kerstin; Fischer, Alexa Josephine; Siakaeva, Elena; Richter, Mathis; Bordbari, Sharareh; Spyra, Ilona; Köster, Christian; Hermann, Dirk M.; Gunzer, Matthias; Felderhoff-Müser, Ursula; Bendix, Ivo; Jablonska, Jadwiga; Herz, Josephine
    Neutrophil dynamics, plasticity and function in acute neurodegeneration following neonatal hypoxia-ischemia
    In: Brain, Behavior and Immunity Vol. 92 (2021) pp. 234 - 244
  • Serdar, Meray; Kempe, Karina; Herrmann, Ralf; Picard, Daniel; Remke, Marc; Herz, Josephine; Bendix, Ivo; Felderhoff-Müser, Ursula; Sabir, Hemmen
    Involvement of CXCL1/CXCR2 During Microglia Activation Following Inflammation-Sensitized Hypoxic-Ischemic Brain Injury in Neonatal Rats
    In: Frontiers in Neurology Vol. 11 (2020) pp. 540878
  • Kaminski, Nicole; Köster, Christian; Mouloud, Yanis; Börger, Verena; Felderhoff-Müser, Ursula; Bendix, Ivo; Giebel, Bernd; Herz, Josephine
    Mesenchymal Stromal Cell-Derived Extracellular Vesicles Reduce Neuroinflammation, Promote Neural Cell Proliferation and Improve Oligodendrocyte Maturation in Neonatal Hypoxic-Ischemic Brain Injury
    In: Frontiers in Cellular Neuroscience Vol. 14 (2020) pp. 601176
  • Dewan, Monia Vanessa; Serdar, Meray; van de Looij, Yohan; Kowallick, Mirjam; Hadamitzky, Martin; Endesfelder, Stefanie; Fandrey, Joachim; Sizonenko, Stéphane V.; Herz, Josephine; Felderhoff-Müser, Ursula; Bendix, Ivo
    Repetitive Erythropoietin Treatment Improves Long-Term Neurocognitive Outcome by Attenuating Hyperoxia-Induced Hypomyelination in the Developing Brain
    In: Frontiers in Neurology Vol. 11 (2020) pp. 804
  • Jungner, Åsa; Vallius Kvist, Suvi; Romantsik, Olga; Bruschettini, Matteo; Ekström, Claes; Bendix, Ivo; Herz, Josephine; Felderhoff-Müser, Ursula; Bibic, Adnan; In'T Zandt, René; Gram, Magnus; Ley, David
    White Matter Brain Development after Exposure to Circulating Cell-Free Hemoglobin and Hyperoxia in a Rat Pup Model
    In: Developmental Neuroscience Vol. 41 (2020) Nr. 3-4, pp. 234 - 246
  • Bendix, Ivo; Hadamitzky, Martin; Herz, Josephine; Felderhoff-Müser, Ursula
    Adverse neuropsychiatric development following perinatal brain injury : from a preclinical perspective
    In: Pediatric Research Vol. 85 (2019) Nr. 2, pp. 198 - 215
  • Serdar, Meray; Mordelt, Annika; Müser, Katharina; Kempe, Karina; Felderhoff-Müser, Ursula; Herz, Josephine; Bendix, Ivo
    Detrimental Impact of Energy Drink Compounds on Developing Oligodendrocytes and Neurons
    In: Cells Vol. 8 (2019) Nr. 11, pp. 1381
  • Serdar, Meray; Kempe, Karina; Rizazad, Mandana; Herz, Josephine; Bendix, Ivo; Felderhoff-Müser, Ursula; Sabir, Hemmen
    Early pro-inflammatory microglia activation after inflammation-sensitized hypoxic-ischemic brain injury in neonatal rats
    In: Frontiers in Cellular Neuroscience Vol. 13 (2019) pp. 237
  • Döppner, Thorsten R.; Herz, Josephine; Bähr, Mathias; Tonchev, Anton B.; Stoykova, Anastassia
    Zbtb20 Regulates Developmental Neurogenesis in the Olfactory Bulb and Gliogenesis After Adult Brain Injury
    In: Molecular Neurobiology Vol. 56 (2019) Nr. 1, pp. 567 - 582
  • Herz, Josephine; Köster, Christian; Reinboth, Barbara S.; Dzietko, Mark; Hansen, Wiebke; Sabir, Hemmen; van Velthoven, Cindy; Bendix, Ivo; Felderhoff-Müser, Ursula
    Interaction between hypothermia and delayed mesenchymal stem cell therapy in neonatal hypoxic-ischemic brain injury
    In: Brain, Behavior and Immunity Vol. 70 (2018) pp. 118 - 130
  • Herz, Josephine; Köster, Christian; Crasmöller, Marius; Abberger, Hanna; Hansen, Wiebke; Felderhoff-Müser, Ursula; Bendix, Ivo
    Peripheral T cell depletion by FTY720 exacerbates hypoxic-ischemic brain injury in neonatal mice
    In: Frontiers in Immunology Vol. 9 (2018) pp. 1696
  • Serdar, Meray; Herz, Josephine; Kempe, Karina; Winterhager, Elke; Jastrow, Holger; Heumann, Rolf; Felderhoff-Müser, Ursula; Bendix, Ivo
    Protection of oligodendrocytes through neuronal overexpression of the small GTPase ras in hyperoxia-induced neonatal brain injury
    In: Frontiers in Neurology Vol. 9 (2018) pp. 175
  • Paterka, Magdalena; Voss, Jan Oliver; Werr, Johannes; Reuter, Eva; Franck, Sophia; Leuenberger, Tina; Herz, Josephine; Radbruch, Helena; Bopp, Tobias; Siffrin, Volker; Zipp, Frauke
    Dendritic cells tip the balance towards induction of regulatory T cells upon priming in experimental autoimmune encephalomyelitis
    In: Journal of Autoimmunity Vol. 76 (2017) pp. 108 - 114
  • Klöfers, Melanie; Kohaut, Jules; Bendix, Ivo; Herz, Josephine; Boos, Vinzenz; Felderhoff-Müser, Ursula; Dzietko, Mark
    Effects of Poly(ADP-Ribose) Polymerase-1 Inhibition in a Neonatal Rodent Model of Hypoxic-Ischemic Injury
    In: BioMed Research International (2017) 2924848
  • Drommelschmidt, Karla; Serdar, Meray; Bendix, Ivo; Herz, Josephine; Bertling, Frederik; Prager, Sebastian; Keller, Matthias; Ludwig, Anna-Kristin; Duhan, Vikas; Radtke, Stefan; de Miroschedji, Kyra; Horn, Peter; van de Looij, Yohan; Giebel, Bernd; Felderhoff-Müser, Ursula
    Mesenchymal stem cell-derived extracellular vesicles ameliorate inflammation-induced preterm brain injury
    In: Brain, Behavior and Immunity Vol. 60 (2017) pp. 220 - 232
  • Engels, Jonas; Elting, Natalie; Braun, Lisa; Bendix, Ivo; Herz, Josephine; Felderhoff-Müser, Ursula; Dzietko, Mark
    Sildenafil Enhances Quantity of Immature Neurons and Promotes Functional Recovery in the Developing Ischemic Mouse Brain
    In: Developmental Neuroscience Vol. 39 (2017) Nr. 1-4, pp. 287 - 297
  • Reinboth, Barbara S; Köster, Christian; Abberger, Hanna; Prager, Sebastian; Bendix, Ivo; Felderhoff-Müser, Ursula; Herz, Josephine
    Endogenous hypothermic response to hypoxia reduces brain injury : Implications for modeling hypoxic-ischemic encephalopathy and therapeutic hypothermia in neonatal mice
    In: Experimental Neurology Vol. 283, Part A (2016) pp. 264 - 275
  • Hoeber, Daniela; Sifringer, Marco; van de Looij, Yohan; Herz, Josephine; Sizonenko, Stéphane V; Kempe, Karina; Serdar, Meray; Palasz, Joanna; Hadamitzky, Martin; Endesfelder, Stefanie; Fandrey, Joachim; Felderhoff-Müser, Ursula; Bendix, Ivo
    Erythropoietin Restores Long-Term Neurocognitive Function Involving Mechanisms of Neuronal Plasticity in a Model of Hyperoxia-Induced Preterm Brain Injury
    In: Oxidative Medicine and Cellular Longevity (2016) pp. 9247493
  • Serdar, Meray; Herz, Josephine; Kempe, Karina; Lumpe, Katharina; Reinboth, Barbara S.; Sizonenko, Stéphane V.; Hou, Xinlin; Herrmann, Ralf; Hadamitzky, Martin; Heumann, Rolf; Hansen, Wiebke; Sifringer, Marco; van de Looij, Yohan; Felderhoff-Müser, Ursula; Bendix, Ivo
    Fingolimod protects against neonatal white matter damage and long-term cognitive deficits caused by hyperoxia
    In: Brain, Behavior and Immunity Vol. 52 (2016) pp. 106 - 119
  • Döppner, Thorsten R.; Herz, Josephine; Görgens, André; Schlechter, Jana; Ludwig, Anna-Kristin; Radtke, Stefan; de Miroschedji, Kyra; Horn, Peter; Giebel, Bernd; Hermann, Dirk M.
    Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression
    In: Stem Cells Translational Medicine Vol. 4 (2015) Nr. 10, pp. 1131 - 1143
  • Herz, Josephine; Sabellek, Pascal; Lane, Thomas E; Gunzer, Matthias; Hermann, Dirk M.; Döppner, Thorsten R.
    Role of Neutrophils in Exacerbation of Brain Injury After Focal Cerebral Ischemia in Hyperlipidemic Mice
    In: Stroke Vol. 46 (2015) Nr. 10, pp. 2916 - 2925
  • Mossakowski, Agata A.; Pohlan, Julian; Bremer, Daniel; Lindquist, Randall; Millward, Jason M.; Bock, Markus; Pollok, Karolin; Mothes, Ronja; Viohl, Leonard; Radbruch, Moritz; Gerhard, Jenny; Bellmann-Strobl, Judith; Behrens, Janina; Infante-Duarte, Carmen; Mähler, Anja; Boschmann, Michael; Rinnenthal, Jan Leo; Füchtemeier, Martina; Herz, Josephine; Pache, Florence C.; Bardua, Markus; Priller, Josef; Hauser, Anja E.; Paul, Friedemann; Niesner, Raluca; Radbruch, Helena
    Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation
    In: Acta Neuropathologica Vol. 130 (2015) Nr. 6, pp. 799 - 814
  • Neumann, Jens; Riek-Burchardt, Monika; Herz, Josephine; Döppner, Thorsten R.; König, Rebecca; Hütten, Heiko; Etemire, Eloho; Männ, Linda; Klingberg, Anika; Fischer, Thomas; Görtler, Michael W; Heinze, Hans-Jochen; Reichardt, Peter; Schraven, Burkhart; Hermann, Dirk M.; Reymann, Klaus G; Gunzer, Matthias
    Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke
    In: Acta Neuropathologica Vol. 129 (2015) Nr. 2, pp. 259 - 277
  • Herz, Josephine; Hagen, Sabine I; Bergmüller, Eileen; Sabellek, Pascal; Göthert, Joachim Rudolf; Buer, Jan; Hansen, Wiebke; Hermann, Dirk M.; Döppner, Thorsten R.
    Exacerbation of ischemic brain injury in hypercholesterolemic mice is associated with pronounced changes in peripheral and cerebral immune responses
    In: Neurobiology of Disease Vol. 62 (2014) pp. 456 - 468
  • Bendix, Ivo; Serdar, Meray; Herz, Josephine; von Haefen, Clarissa; Nasser, Fatme; Rohrer, Benjamin; Endesfelder, Stefanie; Felderhoff-Müser, Ursula; Spies, Claudia D; Sifringer, Marco
    Inhibition of Acetylcholinesterase Modulates NMDA Receptor Antagonist Mediated Alterations in the Developing Brain
    In: International Journal of Molecular Sciences (IJMS) Vol. 15 (2014) Nr. 3, pp. 3784 - 3798
  • Leuenberger, Tina; Pfueller, Caspar F; Luessi, Felix; Bendix, Ivo; Paterka, Magdalena; Prozorovski, Timour; Treue, Denise; Luenstedt, Sarah; Herz, Josephine; Siffrin, Volker; Infante-Duarte, Carmen; Zipp, Frauke; Waiczies, Sonia
    Modulation of Dendritic Cell Immunobiology via Inhibition of 3-Hydroxy-3-Methylglutaryl-CoA (HMG-CoA) Reductase
    In: PLoS ONE Vol. 9 (2014) Nr. 7, pp. e100871
  • Herz, Josephine; Sabellek, P.; Hermann, Dirk M.; Döppner, Thorsten R.
    Neuroprotection by blocking CXCR2 after cerebral ischemia in hypercholesterolemic mice
    In: Journal of Neuroimmunology Vol. 275 (2014) Nr. 1-2, pp. 152 - 153
  • Hasan, Mohammad R; Herz, Josephine; Hermann, Dirk M.; Döppner, Thorsten R.
    Intravascular Perfusion of Carbon Black Ink Allows Reliable Visualization of Cerebral Vessels
    In: JoVE (2013) Nr. 71, pp. e4374
  • Rinnenthal, Jan Leo; Börnchen, Christian; Radbruch, Helena; Andresen, Volker; Mossakowski, Agata; Siffrin, Volker; Seelemann, Thomas; Spiecker, Heinrich; Moll, Ingrid; Herz, Josephine; Hauser, Anja E.; Zipp, Frauke; Behne, Martin J.; Niesner, Raluca
    Parallelized TCSPC for dynamic intravital fluorescence lifetime imaging : quantifying neuronal dysfunction in neuroinflammation
    In: PLoS ONE Vol. 8 (2013) Nr. 4, pp. e60100
  • Leuenberger, Tina; Paterka, Magdalena; Reuter, Eva; Herz, Josephine; Niesner, Raluca A.; Radbruch, Helena; Bopp, Tobias; Zipp, Frauke; Siffrin, Volker
    The role of CD8+T cells and their local interaction with CD4+T cells in myelin oligodendrocyte glycoprotein35-55-induced experimental autoimmune encephalomyelitis
    In: The Journal of Immunology (JI) Vol. 191 (2013) Nr. 10, pp. 4960 - 4968
  • Herz, Josephine; Hagen, S. I.; Hermann, Dirk M.; Döppner, Thorsten R.
    Acute peripheral and CNS immune responses in hypercholesterolemic mice after mild brain ischemia
    In: Journal of Neuroimmunology Vol. 253 (2012) Nr. 1-2, pp. 99
  • Herz, Josephine; Reitmeir, Raluca; Hagen, Sabine I.; Reinboth, Barbara S.; Guo, Zeyun; Zechariah, Anil; ElAli, Ayman; Döppner, Thorsten R.; Bacigaluppi, Marco; Pluchino, Stefano; Kilic, Ülkan; Kilic, Ertugrul; Hermann, Dirk M.
    Intracerebroventricularly delivered VEGF promotes contralesional corticorubral plasticity after focal cerebral ischemia via mechanisms involving anti-inflammatory actions
    In: Neurobiology of Disease Vol. 45 (2012) Nr. 3, pp. 1077 - 1085
  • Hasan, M. R.; Herz, Josephine; Hermann, Dirk M.; Döppner, Thorsten R.
    Intravascular perfusion of carbon black ink allows reliable visualization of cerebral vessels in mice
    In: European Journal of Neurology Vol. 19 (2012) Nr. Suppl. 1, pp. 185
  • Döppner, Thorsten R.; Mlynarczuk-Bialy, Izabela; Kuckelkorn, Ulrike; Kaltwasser, Britta; Herz, Josephine; Hasan, Mohammad R.; Hermann, Dirk M.; Bähr, Mathias
    The novel proteasome inhibitor BSc2118 protects against cerebral ischaemia through HIF1A accumulation and enhanced angioneurogenesis
    In: Brain: A Journal of Neurology Vol. 135 (2012) Nr. 11, pp. 3282 - 3297
  • Döppner, Thorsten R.; Ewert, Tobias A. S.; Tönges, Lars; Herz, Josephine; Zechariah, Anil; ElAli, Ayman; Ludwig, Anna-Kristin; Giebel, Bernd; Nagel, Florian; Dietz, Gunnar P. H.; Weise, Jens; Hermann, Dirk M.; Bähr, Mathias
    Transduction of neural precursor cells with TAT-heat shock protein 70 chaperone : Therapeutic potential against ischemic stroke after intrastriatal and systemic transplantation
    In: Stem Cells Vol. 30 (2012) Nr. 6, pp. 1297 - 1310
  • Hasan, Mohammad R.; Herz, Josephine; Hermann, Dirk M.; Döppner, Thorsten R.
    Visualization of macroscopic cerebral vessel anatomy—A new and reliable technique in mice
    In: Journal of Neuroscience Methods Vol. 204 (2012) Nr. 2, pp. 249 - 253
  • Herz, Josephine; Paterka, Magdalena; Niesner, Raluca A.; Brandt, Alexander U.; Siffrin, Volker; Leuenberger, Tina; Birkenstock, Jerome; Mossakowski, Agata; Glumm, Robert; Zipp, Frauke; Radbruch, Helena
    In vivo imaging of lymphocytes in the CNS reveals different behaviour of naïve T cells in health and autoimmunity
    In: Journal of Neuroinflammation Vol. 8 (2011) pp. 131
  • Schulze-Topphoff, U.; Prat, A.; Prozorovski, T.; Siffrin, V.; Paterka, M.; Herz, Josephine; Bendix, Ivo; Ifergan, I.; Schadock, I.; Mori, M. A.; Van Horssen, J.; Schröter, F.; Smorodchenko, A.; Han, M. H.; Bader, M.; Steinman, L.; Aktas, O.; Zipp, F.
    Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system
    In: Nature Medicine Vol. 15 (2009) Nr. 7, pp. 788 - 793
  • Waiczies, Sonia; Bendix, Ivo; Prozorovski, Timour; Ratner, Maya; Nazarenko, Irina; Pfueller, Caspar F.; Brandt, Alexander U.; Herz, Josephine; Brocke, Stefan; Ullrich, Oliver; Zipp, Frauke
    Geranylgeranylation but not GTP loading determines rho migratory function in T cells
    In: The Journal of Immunology Vol. 179 (2007) Nr. 9, pp. 6024 - 6032