ZMB Member Josephine Herz
ZMB Member
Josephine Herz
Next ZMB-Member
PD Dr. Josephine Herz
Pediatrics Clinic I
University Hospital Essen
Hufelandstr. 55
45122 Essen
- +49 201 723 0
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- Publications
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- ZMB Research Program
Molecular and Chemical Cell Biology
Research Overview
The questions of the experimental perinatal neurosciences are aimed at uncovering cellular and molecular mechanisms of typical diseases of premature babies and sick newborns, with the integrity of the central nervous system being the focus of research.
Publications
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A report on the International Society for Cell & Gene Therapy 2022 Scientific Signature Series, “Therapeutic advances with native and engineered human extracellular vesicles”In: Cytotherapy Vol. 25 (2023) Nr. 8, pp. 810 - 814Online Full Text: dx.doi.org/
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Extracellular vesicles from immortalized mesenchymal stromal cells protect against neonatal hypoxic-ischemic brain injuryIn: Inflammation and Regeneration Vol. 43 (2023) Nr. 1, 24Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Hypothermia combined with extracellular vesicles from clonally expanded immortalized mesenchymal stromal cells improves neurodevelopmental impairment in neonatal hypoxic-ischemic brain injuryIn: Journal of Neuroinflammation Vol. 20 (2023) Nr. 1, 280Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Neuropilin-1 identifies a subset of highly activated CD8⁺ T cells during parasitic and viral infectionsIn: PLoS Pathogens Vol. 19 (2023) Nr. 11, e1011837Online Full Text: dx.doi.org/ (Open Access)
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Perinatal Hyperoxia and Developmental Consequences on the Lung-Brain AxisIn: Oxidative Medicine and Cellular Longevity (2022) 5784146Online Full Text: dx.doi.org/ (Open Access)
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Peripheral immune cells and perinatal brain injury : A double-edged sword?In: Pediatric Research Vol. 91 (2022) Nr. 2, pp. 392 - 403Online Full Text: dx.doi.org/ (Open Access)
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Postischemic Neuroprotection Associated With Anti-Inflammatory Effects by Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles in Aged MiceIn: Stroke Vol. 53 (2022) Nr. 1, pp. E14 - E18Online Full Text: dx.doi.org/ (Open Access)
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Regulatory T Cells Contribute to Sexual Dimorphism in Neonatal Hypoxic-Ischemic Brain InjuryIn: Stroke Vol. 53 (2022) Nr. 2, pp. 381 - 390Online Full Text: dx.doi.org/ (Open Access)
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Hypothermia modulates myeloid cell polarization in neonatal hypoxic–ischemic brain injuryIn: Journal of Neuroinflammation Vol. 18 (2021) Nr. 1, 266Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Neutrophil dynamics, plasticity and function in acute neurodegeneration following neonatal hypoxia-ischemiaIn: Brain, Behavior and Immunity Vol. 92 (2021) pp. 234 - 244Online Full Text: dx.doi.org/ (Open Access)
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Involvement of CXCL1/CXCR2 During Microglia Activation Following Inflammation-Sensitized Hypoxic-Ischemic Brain Injury in Neonatal RatsIn: Frontiers in Neurology Vol. 11 (2020) pp. 540878Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Mesenchymal Stromal Cell-Derived Extracellular Vesicles Reduce Neuroinflammation, Promote Neural Cell Proliferation and Improve Oligodendrocyte Maturation in Neonatal Hypoxic-Ischemic Brain InjuryIn: Frontiers in Cellular Neuroscience Vol. 14 (2020) pp. 601176Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Repetitive Erythropoietin Treatment Improves Long-Term Neurocognitive Outcome by Attenuating Hyperoxia-Induced Hypomyelination in the Developing BrainIn: Frontiers in Neurology Vol. 11 (2020) pp. 804Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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White Matter Brain Development after Exposure to Circulating Cell-Free Hemoglobin and Hyperoxia in a Rat Pup ModelIn: Developmental Neuroscience Vol. 41 (2020) Nr. 3-4, pp. 234 - 246Online Full Text: dx.doi.org/ (Open Access)
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Adverse neuropsychiatric development following perinatal brain injury : from a preclinical perspectiveIn: Pediatric Research Vol. 85 (2019) Nr. 2, pp. 198 - 215Online Full Text: dx.doi.org/ (Open Access)
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Detrimental Impact of Energy Drink Compounds on Developing Oligodendrocytes and NeuronsIn: Cells Vol. 8 (2019) Nr. 11, pp. 1381Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Early pro-inflammatory microglia activation after inflammation-sensitized hypoxic-ischemic brain injury in neonatal ratsIn: Frontiers in Cellular Neuroscience Vol. 13 (2019) pp. 237Online Full Text: dx.doi.org/ (Open Access)
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Zbtb20 Regulates Developmental Neurogenesis in the Olfactory Bulb and Gliogenesis After Adult Brain InjuryIn: Molecular Neurobiology Vol. 56 (2019) Nr. 1, pp. 567 - 582Online Full Text: dx.doi.org/
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Interaction between hypothermia and delayed mesenchymal stem cell therapy in neonatal hypoxic-ischemic brain injuryIn: Brain, Behavior and Immunity Vol. 70 (2018) pp. 118 - 130Online Full Text: dx.doi.org/ (Open Access)
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Peripheral T cell depletion by FTY720 exacerbates hypoxic-ischemic brain injury in neonatal miceIn: Frontiers in Immunology Vol. 9 (2018) pp. 1696Online Full Text: dx.doi.org/ (Open Access)
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Protection of oligodendrocytes through neuronal overexpression of the small GTPase ras in hyperoxia-induced neonatal brain injuryIn: Frontiers in Neurology Vol. 9 (2018) pp. 175Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Dendritic cells tip the balance towards induction of regulatory T cells upon priming in experimental autoimmune encephalomyelitisIn: Journal of Autoimmunity Vol. 76 (2017) pp. 108 - 114Online Full Text: dx.doi.org/
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Effects of Poly(ADP-Ribose) Polymerase-1 Inhibition in a Neonatal Rodent Model of Hypoxic-Ischemic InjuryIn: BioMed Research International (2017) 2924848Online Full Text: dx.doi.org/ (Open Access)
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Mesenchymal stem cell-derived extracellular vesicles ameliorate inflammation-induced preterm brain injuryIn: Brain, Behavior and Immunity Vol. 60 (2017) pp. 220 - 232Online Full Text: dx.doi.org/ (Open Access)
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Sildenafil Enhances Quantity of Immature Neurons and Promotes Functional Recovery in the Developing Ischemic Mouse BrainIn: Developmental Neuroscience Vol. 39 (2017) Nr. 1-4, pp. 287 - 297Online Full Text: dx.doi.org/
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Endogenous hypothermic response to hypoxia reduces brain injury : Implications for modeling hypoxic-ischemic encephalopathy and therapeutic hypothermia in neonatal miceIn: Experimental Neurology Vol. 283, Part A (2016) pp. 264 - 275Online Full Text: dx.doi.org/ (Open Access)
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Erythropoietin Restores Long-Term Neurocognitive Function Involving Mechanisms of Neuronal Plasticity in a Model of Hyperoxia-Induced Preterm Brain InjuryIn: Oxidative Medicine and Cellular Longevity (2016) pp. 9247493Online Full Text: dx.doi.org/ (Open Access)
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Fingolimod protects against neonatal white matter damage and long-term cognitive deficits caused by hyperoxiaIn: Brain, Behavior and Immunity Vol. 52 (2016) pp. 106 - 119Online Full Text: dx.doi.org/ (Open Access)
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Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic ImmunosuppressionIn: Stem Cells Translational Medicine Vol. 4 (2015) Nr. 10, pp. 1131 - 1143Online Full Text: dx.doi.org/ (Open Access)
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Role of Neutrophils in Exacerbation of Brain Injury After Focal Cerebral Ischemia in Hyperlipidemic MiceIn: Stroke Vol. 46 (2015) Nr. 10, pp. 2916 - 2925Online Full Text: dx.doi.org/ (Open Access)
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Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammationIn: Acta Neuropathologica Vol. 130 (2015) Nr. 6, pp. 799 - 814Online Full Text: dx.doi.org/ (Open Access)
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Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental strokeIn: Acta Neuropathologica Vol. 129 (2015) Nr. 2, pp. 259 - 277Online Full Text: dx.doi.org/
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Exacerbation of ischemic brain injury in hypercholesterolemic mice is associated with pronounced changes in peripheral and cerebral immune responsesIn: Neurobiology of Disease Vol. 62 (2014) pp. 456 - 468Online Full Text: dx.doi.org/
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Inhibition of Acetylcholinesterase Modulates NMDA Receptor Antagonist Mediated Alterations in the Developing BrainIn: International Journal of Molecular Sciences (IJMS) Vol. 15 (2014) Nr. 3, pp. 3784 - 3798Online Full Text: dx.doi.org/ (Open Access)
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Modulation of Dendritic Cell Immunobiology via Inhibition of 3-Hydroxy-3-Methylglutaryl-CoA (HMG-CoA) ReductaseIn: PLoS ONE Vol. 9 (2014) Nr. 7, pp. e100871Online Full Text: dx.doi.org/ (Open Access)
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Neuroprotection by blocking CXCR2 after cerebral ischemia in hypercholesterolemic miceIn: Journal of Neuroimmunology Vol. 275 (2014) Nr. 1-2, pp. 152 - 153Online Full Text: dx.doi.org/
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Intravascular Perfusion of Carbon Black Ink Allows Reliable Visualization of Cerebral VesselsIn: JoVE (2013) Nr. 71, pp. e4374Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Parallelized TCSPC for dynamic intravital fluorescence lifetime imaging : quantifying neuronal dysfunction in neuroinflammationIn: PLoS ONE Vol. 8 (2013) Nr. 4, pp. e60100Online Full Text: dx.doi.org/ (Open Access)
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The role of CD8+T cells and their local interaction with CD4+T cells in myelin oligodendrocyte glycoprotein35-55-induced experimental autoimmune encephalomyelitisIn: The Journal of Immunology (JI) Vol. 191 (2013) Nr. 10, pp. 4960 - 4968Online Full Text: dx.doi.org/
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Acute peripheral and CNS immune responses in hypercholesterolemic mice after mild brain ischemiaIn: Journal of Neuroimmunology Vol. 253 (2012) Nr. 1-2, pp. 99
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Intracerebroventricularly delivered VEGF promotes contralesional corticorubral plasticity after focal cerebral ischemia via mechanisms involving anti-inflammatory actionsIn: Neurobiology of Disease Vol. 45 (2012) Nr. 3, pp. 1077 - 1085Online Full Text: dx.doi.org/
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Intravascular perfusion of carbon black ink allows reliable visualization of cerebral vessels in miceIn: European Journal of Neurology Vol. 19 (2012) Nr. Suppl. 1, pp. 185
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The novel proteasome inhibitor BSc2118 protects against cerebral ischaemia through HIF1A accumulation and enhanced angioneurogenesisIn: Brain: A Journal of Neurology Vol. 135 (2012) Nr. 11, pp. 3282 - 3297Online Full Text: dx.doi.org/
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Transduction of neural precursor cells with TAT-heat shock protein 70 chaperone : Therapeutic potential against ischemic stroke after intrastriatal and systemic transplantationIn: Stem Cells Vol. 30 (2012) Nr. 6, pp. 1297 - 1310Online Full Text: dx.doi.org/
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Visualization of macroscopic cerebral vessel anatomy—A new and reliable technique in miceIn: Journal of Neuroscience Methods Vol. 204 (2012) Nr. 2, pp. 249 - 253Online Full Text: dx.doi.org/
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In vivo imaging of lymphocytes in the CNS reveals different behaviour of naïve T cells in health and autoimmunityIn: Journal of Neuroinflammation Vol. 8 (2011) pp. 131Online Full Text: dx.doi.org/ (Open Access)
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Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous systemIn: Nature Medicine Vol. 15 (2009) Nr. 7, pp. 788 - 793Online Full Text: dx.doi.org/
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Geranylgeranylation but not GTP loading determines rho migratory function in T cellsIn: The Journal of Immunology Vol. 179 (2007) Nr. 9, pp. 6024 - 6032Online Full Text: dx.doi.org/