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ZMB Member Josephine Herz

ZMB Member
Josephine Herz

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Josephine Herz portrait
© UKE

PD Dr. Josephine Herz

Group

Experimental Perinatal Neuroscience

Pediatrics Clinic I
University Hospital Essen
Hufelandstr. 55
45122 Essen

Research Overview

The questions of the experimental perinatal neurosciences are aimed at uncovering cellular and molecular mechanisms of typical diseases of premature babies and sick newborns, with the integrity of the central nervous system being the focus of research.

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Selected Publications

    Journal articles

  • Obst, Stefanie; Serdar, Meray; Herz, Josephine; Kempe, Karina; Assili, Meriem; Rizazad, Mandana; Hirani, Dharmesh; Alejandre Alcazar, Miguel A.; Endesfelder, Stefanie; Möbius, Marius A.; Rüdiger, Mario; Felderhoff-Müser, Ursula; Bendix, Ivo.
    A Novel Model for Simultaneous Evaluation of Hyperoxia-Mediated Brain and Lung Injury in Neonatal Rats
    In: Cells Vol. 14 (2025) Nr. 6, pp. 443
    Online Full Text: dx.doi.org/ (Open Access)
  • Wang, Chen; Börger, Verena; Mohamud Yusuf, Ayan; Tertel, Tobias; Stambouli, Oumaima; Murke, Florian; Freund, Nico; Kleinschnitz, Christoph; Herz, Josephine; Gunzer, Matthias; Popa-Wagner, Aurel; Döppner, Thorsten R.; Giebel, Bernd; Hermann, Dirk M.
    Postischemic Neuroprotection Associated With Anti-Inflammatory Effects by Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles in Aged Mice
    In: Stroke Vol. 53 (2022) Nr. 1, pp. E14 - E18
    Online Full Text: dx.doi.org/ (Open Access)
  • Beckmann, Lucia; Obst, Stefanie; Labusek, Nicole; Abberger, Hanna; Köster, Christian; Klein-Hitpaß, Ludger; Schumann, Sven; Kleinschnitz, Christoph; Hermann, Dirk M.; Felderhoff-Müser, Ursula; Bendix, Ivo; Hansen, Wiebke; Herz, Josephine.
    Regulatory T Cells Contribute to Sexual Dimorphism in Neonatal Hypoxic-Ischemic Brain Injury
    In: Stroke Vol. 53 (2022) Nr. 2, pp. 381 - 390
    Online Full Text: dx.doi.org/ (Open Access)
  • Mülling, Kerstin; Fischer, Alexa Josephine; Siakaeva, Elena; Richter, Mathis; Bordbari, Sharareh; Spyra, Ilona; Köster, Christian; Hermann, Dirk M.; Gunzer, Matthias; Felderhoff-Müser, Ursula; Bendix, Ivo; Jablonska, Jadwiga; Herz, Josephine.
    Neutrophil dynamics, plasticity and function in acute neurodegeneration following neonatal hypoxia-ischemia
    In: Brain, Behavior and Immunity Vol. 92 (2021) pp. 234 - 244
    Online Full Text: dx.doi.org/ (Open Access)
  • Serdar, Meray; Kempe, Karina; Herrmann, Ralf; Picard, Daniel; Remke, Marc; Herz, Josephine; Bendix, Ivo; Felderhoff-Müser, Ursula; Sabir, Hemmen.
    Involvement of CXCL1/CXCR2 During Microglia Activation Following Inflammation-Sensitized Hypoxic-Ischemic Brain Injury in Neonatal Rats
    In: Frontiers in Neurology Vol. 11 (2020) pp. 540878
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Kaminski, Nicole; Köster, Christian; Mouloud, Yanis; Börger, Verena; Felderhoff-Müser, Ursula; Bendix, Ivo; Giebel, Bernd; Herz, Josephine.
    Mesenchymal Stromal Cell-Derived Extracellular Vesicles Reduce Neuroinflammation, Promote Neural Cell Proliferation and Improve Oligodendrocyte Maturation in Neonatal Hypoxic-Ischemic Brain Injury
    In: Frontiers in Cellular Neuroscience Vol. 14 (2020) pp. 601176
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Dewan, Monia Vanessa; Serdar, Meray; van de Looij, Yohan; Kowallick, Mirjam; Hadamitzky, Martin; Endesfelder, Stefanie; Fandrey, Joachim; Sizonenko, Stéphane V.; Herz, Josephine; Felderhoff-Müser, Ursula; Bendix, Ivo.
    Repetitive Erythropoietin Treatment Improves Long-Term Neurocognitive Outcome by Attenuating Hyperoxia-Induced Hypomyelination in the Developing Brain
    In: Frontiers in Neurology Vol. 11 (2020) pp. 804
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Jungner, Åsa; Vallius Kvist, Suvi; Romantsik, Olga; Bruschettini, Matteo; Ekström, Claes; Bendix, Ivo; Herz, Josephine; Felderhoff-Müser, Ursula; Bibic, Adnan; In'T Zandt, René; Gram, Magnus; Ley, David.
    White Matter Brain Development after Exposure to Circulating Cell-Free Hemoglobin and Hyperoxia in a Rat Pup Model
    In: Developmental Neuroscience Vol. 41 (2020) Nr. 3-4, pp. 234 - 246
    Online Full Text: dx.doi.org/ (Open Access)
  • Serdar, Meray; Mordelt, Annika; Müser, Katharina; Kempe, Karina; Felderhoff-Müser, Ursula; Herz, Josephine; Bendix, Ivo.
    Detrimental Impact of Energy Drink Compounds on Developing Oligodendrocytes and Neurons
    In: Cells Vol. 8 (2019) Nr. 11, pp. 1381
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Serdar, Meray; Kempe, Karina; Rizazad, Mandana; Herz, Josephine; Bendix, Ivo; Felderhoff-Müser, Ursula; Sabir, Hemmen.
    Early pro-inflammatory microglia activation after inflammation-sensitized hypoxic-ischemic brain injury in neonatal rats
    In: Frontiers in Cellular Neuroscience Vol. 13 (2019) pp. 237
    Online Full Text: dx.doi.org/ (Open Access)
  • Herz, Josephine; Köster, Christian; Reinboth, Barbara S.; Dzietko, Mark; Hansen, Wiebke; Sabir, Hemmen; van Velthoven, Cindy; Bendix, Ivo; Felderhoff-Müser, Ursula.
    Interaction between hypothermia and delayed mesenchymal stem cell therapy in neonatal hypoxic-ischemic brain injury
    In: Brain, Behavior and Immunity Vol. 70 (2018) pp. 118 - 130
    Online Full Text: dx.doi.org/ (Open Access)
  • Herz, Josephine; Köster, Christian; Crasmöller, Marius; Abberger, Hanna; Hansen, Wiebke; Felderhoff-Müser, Ursula; Bendix, Ivo.
    Peripheral T cell depletion by FTY720 exacerbates hypoxic-ischemic brain injury in neonatal mice
    In: Frontiers in Immunology Vol. 9 (2018) pp. 1696
    Online Full Text: dx.doi.org/ (Open Access)
  • Serdar, Meray; Herz, Josephine; Kempe, Karina; Winterhager, Elke; Jastrow, Holger; Heumann, Rolf; Felderhoff-Müser, Ursula; Bendix, Ivo.
    Protection of oligodendrocytes through neuronal overexpression of the small GTPase ras in hyperoxia-induced neonatal brain injury
    In: Frontiers in Neurology Vol. 9 (2018) pp. 175
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Drommelschmidt, Karla; Serdar, Meray; Bendix, Ivo; Herz, Josephine; Bertling, Frederik; Prager, Sebastian; Keller, Matthias; Ludwig, Anna-Kristin; Duhan, Vikas; Radtke, Stefan; de Miroschedji, Kyra; Horn, Peter; van de Looij, Yohan; Giebel, Bernd; Felderho et al.
    Mesenchymal stem cell-derived extracellular vesicles ameliorate inflammation-induced preterm brain injury
    In: Brain, Behavior and Immunity Vol. 60 (2017) pp. 220 - 232
    Online Full Text: dx.doi.org/ (Open Access)
  • Engels, Jonas; Elting, Natalie; Braun, Lisa; Bendix, Ivo; Herz, Josephine; Felderhoff-Müser, Ursula; Dzietko, Mark.
    Sildenafil Enhances Quantity of Immature Neurons and Promotes Functional Recovery in the Developing Ischemic Mouse Brain
    In: Developmental Neuroscience Vol. 39 (2017) Nr. 1-4, pp. 287 - 297
    Online Full Text: dx.doi.org/
  • Serdar, Meray; Herz, Josephine; Kempe, Karina; Lumpe, Katharina; Reinboth, Barbara S.; Sizonenko, Stéphane V.; Hou, Xinlin; Herrmann, Ralf; Hadamitzky, Martin; Heumann, Rolf; Hansen, Wiebke; Sifringer, Marco; van de Looij, Yohan; Felderhoff-Müser, Ursula; et al.
    Fingolimod protects against neonatal white matter damage and long-term cognitive deficits caused by hyperoxia
    In: Brain, Behavior and Immunity Vol. 52 (2016) pp. 106 - 119
    Online Full Text: dx.doi.org/ (Open Access)
  • Herz, Josephine; Sabellek, Pascal; Lane, Thomas E; Gunzer, Matthias; Hermann, Dirk M.; Döppner, Thorsten R.
    Role of Neutrophils in Exacerbation of Brain Injury After Focal Cerebral Ischemia in Hyperlipidemic Mice
    In: Stroke Vol. 46 (2015) Nr. 10, pp. 2916 - 2925
    Online Full Text: dx.doi.org/ (Open Access)
  • Mossakowski, Agata A.; Pohlan, Julian; Bremer, Daniel; Lindquist, Randall; Millward, Jason M.; Bock, Markus; Pollok, Karolin; Mothes, Ronja; Viohl, Leonard; Radbruch, Moritz; Gerhard, Jenny; Bellmann-Strobl, Judith; Behrens, Janina; Infante-Duarte, Carmen; et al.
    Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation
    In: Acta Neuropathologica Vol. 130 (2015) Nr. 6, pp. 799 - 814
    Online Full Text: dx.doi.org/ (Open Access)
  • Neumann, Jens; Riek-Burchardt, Monika; Herz, Josephine; Döppner, Thorsten R.; König, Rebecca; Hütten, Heiko; Etemire, Eloho; Männ, Linda; Klingberg, Anika; Fischer, Thomas; Görtler, Michael W; Heinze, Hans-Jochen; Reichardt, Peter; Schraven, Burkhart; Herm et al.
    Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke
    In: Acta Neuropathologica Vol. 129 (2015) Nr. 2, pp. 259 - 277
    Online Full Text: dx.doi.org/
  • Schulze-Topphoff, U.; Prat, A.; Prozorovski, T.; Siffrin, V.; Paterka, M.; Herz, Josephine; Bendix, Ivo; Ifergan, I.; Schadock, I.; Mori, M. A.; Van Horssen, J.; Schröter, F.; Smorodchenko, A.; Han, M. H.; Bader, M.; Steinman, L.; Aktas, O.; Zipp, F.
    Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system
    In: Nature Medicine Vol. 15 (2009) Nr. 7, pp. 788 - 793
    Online Full Text: dx.doi.org/