ZMB Member Alexander Schramm
ZMB Member
Alexander Schramm
Next ZMB-Member
Prof. Dr. Alexander Schramm
Group
Molecular OncologyClinic for Internal Medicine (Tumor Research)
University Hospital Essen
Hufelandstraße 55
45147 Essen
- +49 201 723 1630
- Website
- Selected Publications
- Publication Metrics
- ZMB Research Program
Oncology
Research Overview
- Mechanisms of Resistance in Lung Tumors
- Signal Transduction in Tumor Cells
- Models for Tumor Development and Progression
- Translational Immuno Oncology
- Metabolic plasticity of tumor cells
Selected Publications
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Hypoxia Induces Resistance to EGFR Inhibitors in Lung Cancer Cells via Upregulation of FGFR1 and the MAPK PathwayIn: Cancer Research Vol. 80 (2020) Nr. 21, pp. 4655 - 4667Online Full Text: dx.doi.org/ (Open Access)
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A mechanistic classification of clinical phenotypes in neuroblastomaIn: Science Vol. 362 (2018) Nr. 6419, pp. 1165 - 1170Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Targeting MYCN-driven transcription by BET-bromodomain inhibitionIn: Clinical Cancer Research Vol. 22 (2016) Nr. 10, pp. 2470 - 2781Online Full Text: dx.doi.org/ (Open Access)
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Mutational dynamics between primary and relapse neuroblastomasIn: Nature Genetics Vol. 47 (2015) Nr. 8, pp. 872 - 877Online Full Text: dx.doi.org/
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Targeting super-enhancer induced gene expression with the novel BRD4 inhibitor OTX015 in preclinical models of MYCN-amplified neuroblastomaIn: Cancer Research Vol. 75 (2015) Nr. 15 Suppl., pp. 4731Online Full Text: dx.doi.org/
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Telomerase activation by genomic rearrangements in high-risk neuroblastomaIn: Nature Vol. 526 (2015) Nr. 7575, pp. 700 - 704Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Telomerase activation by genomic rearrangements in high-risk neuroblastomaIn: Cancer Research Vol. 75 (2015) Nr. 15 Suppl., pp. LB - 210Online Full Text: dx.doi.org/
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LIN28B drives neuroblastoma oncogenesis through let7-MYCN signalingIn: Cancer Research Vol. 73 (2013) Nr. 8 Suppl. 1, pp. 4596Online Full Text: dx.doi.org/
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LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppressionIn: Nature Genetics Vol. 44 (2012) Nr. 11, pp. 1199 - 1206Online Full Text: dx.doi.org/
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Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiationIn: Leukemia Vol. 26 (2012) Nr. 9, pp. 2039 - 2051Online Full Text: dx.doi.org/
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Smac mimetic LBW242 sensitizes XIAP-overexpressing neuroblastoma cells for TNF-α-independent apoptosisIn: Cancer Research Vol. 72 (2012) Nr. 10, pp. 2645 - 2656Online Full Text: dx.doi.org/ (Open Access)
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Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formationIn: Nature Cell Biology Vol. 14 (2012) Nr. 9, pp. 958 - 965Online Full Text: dx.doi.org/
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High ALK Receptor Tyrosine Kinase Expression Supersedes ALK Mutation as a Determining Factor of an Unfavorable Phenotype in Primary NeuroblastomaIn: Clinical Cancer Research Vol. 17 (2011) Nr. 15, pp. 5082 - 5092Online Full Text: dx.doi.org/
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Polo-like kinase 1 is a therapeutic target in high-risk neuroblastomaIn: Clinical Cancer Research Vol. 17 (2011) Nr. 4, pp. 731 - 741Online Full Text: dx.doi.org/
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miRNA expression profiling enables risk stratification in archived and fresh neuroblastoma tumor samplesIn: Clinical Cancer Research Vol. 17 (2011) Nr. 24, pp. 7684 - 7692Online Full Text: dx.doi.org/
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Accurate outcome prediction in neuroblastoma across independent data sets using a multigene signatureIn: Clinical Cancer Research Vol. 16 (2010) Nr. 5, pp. 1532 - 1541Online Full Text: dx.doi.org/
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Chromosomal and microRNA expression patterns reveal biologically distinct subgroups of 11q- neuroblastomaIn: Clinical Cancer Research Vol. 16 (2010) Nr. 11, pp. 2971 - 2978Online Full Text: dx.doi.org/
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Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplificationIn: Clinical Cancer Research Vol. 16 (2010) Nr. 17, pp. 4353 - 4362Online Full Text: dx.doi.org/
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Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma : implications for therapyIn: Cancer Research Vol. 69 (2009) Nr. 5, pp. 2065 - 2071Online Full Text: dx.doi.org/ (Open Access)
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Meta-mining of neuroblastoma and neuroblast gene expression profiles reveals candidate therapeutic compoundsIn: Clinical Cancer Research Vol. 15 (2009) Nr. 11, pp. 3690 - 3696Online Full Text: dx.doi.org/
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Targeting the phosphoinositide 3-kinase isoform p110delta impairs growth and survival in neuroblastoma cellsIn: Clinical Cancer Research Vol. 14 (2008) Nr. 4, pp. 1172 - 1181Online Full Text: dx.doi.org/
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Fractalkine (CX3CL1)- and interleukin-2-enriched neuroblastoma microenvironment induces eradication of metastases mediated by T cells and natural killer cellsIn: Cancer Research Vol. 67 (2007) Nr. 5, pp. 2331 - 2338Online Full Text: dx.doi.org/
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Translating expression profiling into a clinically feasible test to predict neuroblastoma outcomeIn: Clinical Cancer Research Vol. 13 (2007) Nr. 5, pp. 1459 - 1465Online Full Text: dx.doi.org/
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Identification of a set of seven genes for the monitoring of minimal residual disease in pediatric acute myeloid leukemiaIn: Clinical Cancer Research Vol. 12 (2006) Nr. 8, pp. 2434 - 2441Online Full Text: dx.doi.org/
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Keratoepithelin suppresses the progression of experimental human neuroblastomasIn: Cancer Research Vol. 66 (2006) Nr. 10, pp. 5314 - 5321Online Full Text: dx.doi.org/