ZMB member Samuel Peña-Llopis
ZMB Member
Samuel Peña-Llopis
Next ZMB-Member
Dr. Samuel Peña-Llopis
Group
Translational GenomicsDepartment of Ophthalmology
University Hospital Essen
Hufelandstraße 55
45122 Essen
- +49 201 723 7312
- Website
- Selected Publications
- Publication Metrics
- ZMB Research Program
Oncology
Research Overview
- Renal Cell Carcinoma and Uveal Melanoma
- Molecular Genetics and Functional Genomics
- Bioinformatics
- Epigenetic Modifier BAP1
- Patient-derived Organoids
Selected Publications
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GRB2 is a BECN1 interacting protein that regulates autophagyIn: Cell Death and Disease Vol. 15 (2024) Nr. 1, 14Online Full Text: dx.doi.org/ (Open Access)
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Synergistic Sensitization of High-Grade Serous Ovarian Cancer Cells Lacking Caspase-8 Expression to Chemotherapeutics Using Combinations of Small-Molecule BRD4 and CDK9 InhibitorsIn: Cancers Vol. 16 (2024) Nr. 1, 107Online Full Text: dx.doi.org/ (Open Access)
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Correction : The non-apoptotic function of Caspase-8 in negatively regulating the CDK9-mediated Ser2 phosphorylation of RNA polymerase II in cervical cancerIn: Cellular and Molecular Life Sciences - CMLS Vol. 80 (2023) Nr. 3, 64Online Full Text: dx.doi.org/ (Open Access)
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Rescue of p53 functions by in vitro-transcribed mRNA impedes the growth of high-grade serous ovarian cancerIn: Cancer Communications Vol. 44 (2023) Nr. 1, pp. 101 - 126Online Full Text: dx.doi.org/ (Open Access)
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A new perspective on immune evasion : Escaping immune surveillance by inactivating tumor suppressorsIn: Signal Transduction and Targeted Therapy Vol. 7 (2022) Nr. 1, 15Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Nintedanib and Dasatinib Treatments Induce Protective Autophagy as a Potential Resistance Mechanism in MPM CellsIn: Frontiers in Cell and Developmental Biology Vol. 10 (2022) 852812Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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The non-apoptotic function of Caspase-8 in negatively regulating the CDK9-mediated Ser2 phosphorylation of RNA polymerase II in cervical cancerIn: Cellular and Molecular Life Sciences - CMLS Vol. 79 (2022) Nr. 12, 597Online Full Text: dx.doi.org/ (Open Access)
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A BAP1 synonymous mutation results in exon skipping, loss of function and worse patient prognosisIn: iScience Vol. 24 (2021) Nr. 3, 102173Online Full Text: dx.doi.org/ (Open Access)
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Leadership challenges defusedIn: Science Vol. 371 (2021) Nr. 6533, pp. 1070Online Full Text: dx.doi.org/ (Open Access)
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Monosomy 3 is linked to resistance to mek inhibitors in uveal melanomaIn: International Journal of Molecular Sciences (IJMS) Vol. 22 (2021) Nr. 13, 6727Online Full Text: dx.doi.org/ (Open Access)
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Regulation of beclin 1-mediated autophagy by oncogenic tyrosine kinasesIn: International Journal of Molecular Sciences (IJMS) Vol. 21 (2020) Nr. 23, pp. 9210Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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TFEB-mediated lysosomal biogenesis and lysosomal drug sequestration confer resistance to MEK inhibition in pancreatic cancerIn: Cell Death Discovery Vol. 6 (2020) Nr. 1, 12Online Full Text: dx.doi.org/ (Open Access)
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Association of Polo-Like Kinase 3 and PhosphoT273 Caspase 8 Levels With Disease-Related Outcomes Among Cervical Squamous Cell Carcinoma Patients Treated With Chemoradiation and BrachytherapyIn: Frontiers in Oncology Vol. 9 (2019) pp. 742Online Full Text: dx.doi.org/ (Open Access)
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Correction: : γKlotho is a novel marker and cell survival factor in a subset of triple negative breast cancersIn: OncoTarget Vol. 10 (2019) Nr. 8, pp. 916 - 916Online Full Text: dx.doi.org/ (Open Access)
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Cullin 5 is a novel candidate tumor suppressor in renal cell carcinoma involved in the maintenance of genome stabilityIn: Oncogenesis Vol. 8 (2019) Nr. 1, pp. 4Online Full Text: dx.doi.org/ (Open Access)
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Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand BreaksIn: Cell Reports Vol. 25 (2018) Nr. 4, pp. 1040 - 1050.e5Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Multistep regulation of TFEB by MTORC1In: Autophagy Vol. 13 (2017) Nr. 3, pp. 464 - 472Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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An integrative somatic mutation analysis to identify pathways linked with survival outcomes across 19 cancer typesIn: Bioinformatics Vol. 32 (2016) Nr. 11, pp. 1643 - 1651Online Full Text: dx.doi.org/ Online Full Text
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Fibroblast growth factor receptor-dependent and -independent paracrine signaling by sunitinib-resistant renal cell carcinomaIn: Molecular and Cellular Biology (MCB) Vol. 36 (2016) Nr. 13, pp. 1836 - 1855Online Full Text: dx.doi.org/ Online Full Text
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Macrophage PPARγ inhibits GPR132 to mediate the anti-tumor effects of rosiglitazoneIn: eLife Vol. 5 (2016) pp. e18501Online Full Text: dx.doi.org/ (Open Access)
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Unique epigenetic gene profiles define human breast cancers with poor prognosisIn: OncoTarget Vol. 7 (2016) Nr. 52, pp. 85819 - 85831Online Full Text: dx.doi.org/ Online Full Text
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γKlotho is a novel marker and cell survival factor in a subset of triple negative breast cancersIn: OncoTarget Vol. 7 (2016) Nr. 3, pp. 2611 - 2628Online Full Text: dx.doi.org/ (Open Access)
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Prospective evaluation of plasma levels of ANGPT2, TuM2PK, and VEGF in patients with renal cell carcinoma Urological oncologyIn: BMC Urology Vol. 15 (2015) Nr. 1, pp. 1 - 8Online Full Text: dx.doi.org/ (Open Access)
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Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypesIn: Nature Genetics Vol. 47 (2015) Nr. 1, pp. 13 - 21Online Full Text: dx.doi.org/ (Open Access)
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N-Acetylcysteine boosts xenobiotic detoxification in shellfishIn: Aquatic Toxicology Vol. 154 (2014) pp. 131 - 140Online Full Text: dx.doi.org/
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Nullifying the CDKN2AB locus promotes mutant K-ras lung tumorigenesisIn: Molecular Cancer Research Vol. 12 (2014) Nr. 6, pp. 912 - 923Online Full Text: dx.doi.org/ (Open Access)
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A novel germline mutation in BAP1 predisposes to familial clear-cell renal cell carcinomaIn: Molecular Cancer Research Vol. 11 (2013) Nr. 9, pp. 1061 - 1071Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growthIn: Nature Communications Vol. 4 (2013) pp. 2035Online Full Text: dx.doi.org/ (Open Access)
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Cooperation and antagonism among cancer genes: The renal cancer paradigmIn: Cancer Research Vol. 73 (2013) Nr. 14, pp. 4173 - 4179Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: A retrospective analysis with independent validationIn: The Lancet Oncology Vol. 14 (2013) Nr. 2, pp. 159 - 167Online Full Text: dx.doi.org/ (Open Access)
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Platelet-derived growth factor/vascular endothelial growth factor receptor inactivation by sunitinib results in Tsc1/Tsc2-dependent inhibition of TORC1In: Molecular and Cellular Biology (MCB) Vol. 33 (2013) Nr. 19, pp. 3762 - 3779Online Full Text: dx.doi.org/ Online Full Text
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Simultaneous isolation of high-quality DNA, RNA, miRNA and proteins from tissues for genomic applicationsIn: Nature Protocols Vol. 8 (2013) Nr. 11, pp. 2240 - 2255Online Full Text: dx.doi.org/ (Open Access)
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A validated tumorgraft model reveals activity of dovitinib against renal cell carcinomaIn: Science Translational Medicine Vol. 4 (2012) Nr. 137, 137ra75Online Full Text: dx.doi.org/ (Open Access)
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BAP1 loss defines a new class of renal cell carcinomaIn: Nature Genetics Vol. 44 (2012) Nr. 7, pp. 751 - 759Online Full Text: dx.doi.org/ (Open Access)
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Chemical inhibition of RNA viruses reveals REDD1 as a host defense factorIn: Nature Chemical Biology Vol. 7 (2011) Nr. 10, pp. 712 - 719Online Full Text: dx.doi.org/ Online Full Text
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Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinomaIn: Molecular Cancer Research Vol. 9 (2011) Nr. 9, pp. 1255 - 1265Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Regulation of TFEB and V-ATPases by mTORC1In: The EMBO Journal Vol. 30 (2011) Nr. 16, pp. 3242 - 3258Online Full Text: dx.doi.org/ (Open Access)
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Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic deathIn: Oncogene Vol. 30 (2011) Nr. 18, pp. 2147 - 2160Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Expression analysis of the fpr (ferredoxin-NADP⁺ reductase) gene in Pseudomonas putida KT2440In: Biochemical and Biophysical Research Communications (BBRC) Vol. 339 (2006) Nr. 4, pp. 1246 - 1254Online Full Text: dx.doi.org/
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Regulation of superoxide stress in Pseudomonas putida KT2440 is different from the SoxR paradigm in Escherichia coliIn: Biochemical and Biophysical Research Communications (BBRC) Vol. 341 (2006) Nr. 1, pp. 51 - 56Online Full Text: dx.doi.org/
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Antioxidants as Potentially Safe Antidotes for Organophosphorus PoisoningIn: Current Enzyme Inhibition Vol. 1 (2005) Nr. 2, pp. 147 - 156Online Full Text: dx.doi.org/
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Constitutive soxR mutations contribute to multiple-antibiotic resistance in clinical Escherichia coli isolatesIn: Antimicrobial Agents and Chemotherapy Vol. 49 (2005) Nr. 7, pp. 2746 - 2752Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Effect of fish meal replacement by plant protein sources on non-specific defence mechanisms and oxidative stress in gilthead sea bream (Sparus aurata)In: Aquaculture Vol. 249 (2005) Nr. 1-4, pp. 387 - 400Online Full Text: dx.doi.org/ (Open Access)
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Fish tolerance to organophosphate-induced oxidative stress is dependent on the glutathione metabolism and enhanced by N-acetylcysteineIn: Aquatic Toxicology Vol. 65 (2003) Nr. 4, pp. 337 - 360Online Full Text: dx.doi.org/
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Increased recovery of brain acetylcholinesterase activity in dichlorvos-intoxicated European eels Anguilla anguilla by bath treatment with N-acetylcysteineIn: Diseases of Aquatic Organisms Vol. 55 (2003) Nr. 3, pp. 237 - 245Online Full Text: dx.doi.org/ (Open Access)
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Impaired glutathione redox status is associated with decreased survival in two organophosphate-poisoned marine bivalvesIn: Chemosphere Vol. 47 (2002) Nr. 5, pp. 485 - 497Online Full Text: dx.doi.org/
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Glutathione-dependent resistance of the European eel Anguilla anguilla to the herbicide molinateIn: Chemosphere Vol. 45 (2001) Nr. 4-5, pp. 671 - 681Online Full Text: dx.doi.org/
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Role of glutathione in thiobencarb resistance in the European eel Anguilla anguillaIn: Ecotoxicology and Environmental Safety Vol. 46 (2000) Nr. 1, pp. 51 - 56Online Full Text: dx.doi.org/
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Ultrastructural morphogenesis of pectinid spat from the western Mediterranean : A way to differentiate seven generaIn: Journal of Shellfish Research Vol. 17 (1998) Nr. 1-3, pp. 123 - 130