ZMB Member Peter Horn

ZMB Member
Peter Horn

Next ZMB-Member
portrait photo of ZMB member Peter Horn
© UKE/P.Horn

Prof. Dr. Peter Horn

Director of:

Institute for Transfusion Medicine

University Hospital Essen
Hufelandstr. 55
45122 Essen

Research Overview

  • Hematopoietic differentiation of pluripotent stem cells (iPS and ESC)
  • Developmental biology of somatic stem cells
  • Immunogenetics and Transplant Immunology
  • Optimization of donor selection in stem cell transplantation
  • GMP-compliant development of cellular therapeutics
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Selected Publications

    Journal articles

  • Schwarz, Tatjana; Ptok, Johannes; Damagnez, Maximilian; Menne, Christopher; Alizei, Elahe Salimi; Lang-Meli, Julia; Maas, Michelle; Habermann, Daniel; Hoffmann, Daniel; Schulze zur Wiesch, Julian; Lauer, Georg; Kefalakes, Helenie; Cornberg, Markus; Kraft, Anke RM.; Gliga, Smaranda; Bock, Hans H.; Horn, Peter A.; Maini, Mala K.; Thimme, Robert; Wedemeyer, Heiner; Nattermann, Jacob; Heinemann, Falko M.; Luedde, Tom; Neumann-Haefelin, Christoph; Walker, Andreas; Timm, Jörg
    HBV shows different levels of adaptation to HLA class I-associated selection pressure correlating with markers of replication
    In: Journal of Hepatology (2024) in press
    Online Full Text: dx.doi.org/ (Open Access)
  • Barsegian, Vahé; Möckel, Daniel; Buehler, Sebastian; Müller, Stefan P.; Kreissl, Michael C.; Ostheim, Patrick; Horn, Peter A.; Lindemann, Monika
    Lymphocyte Function at Baseline Could Be a New Predictor of Tumor Burden following Six Cycles of Radium-223 Therapy in Patients with Metastasized, Castration-Resistant Prostate Cancer
    In: Cancers Vol. 16 (2024) Nr. 5, 886
    Online Full Text: dx.doi.org/ (Open Access)
  • Domouchtsidou, Aglaia; Beckmann, Ferdinand; Marenbach, Beate; Mueller, Stefan P.; Best, Jan; Herrmann, Ken; Horn, Peter; Barsegian, Vahé; Lindemann, Monika
    In Patients Treated by Selective Internal Radiotherapy, Cellular In Vitro Immune Function Is Predictive of Survival
    In: Cancers Vol. 15 (2023) Nr. 16, 4055
    Online Full Text: dx.doi.org/ (Open Access)
  • Engelke, Merlin; Schmidt, Cynthia Sabrina; Baldini, Giulia; Parmar, Vicky; Hosch, René; Borys, Katarzyna; Koitka, Sven; Turki, Amin T.; Haubold, Johannes; Horn, Peter; Nensa, Felix
    Optimizing platelet transfusion through a personalized deep learning risk assessment system for demand management
    In: Blood Vol. 142 (2023) Nr. 26, pp. 2315 - 2326
    Online Full Text: dx.doi.org/
  • Meurer, Thuja; Crivello, Pietro; Metzing, Maximilian Frederik; Kester, Michel; Megger, Dominik A.; Chen, Weiqiang; van Veelen, PA; van Balen, Peter; Westendorf, Astrid; Homa, Georg; Layer, Sophia E.; Turki, Amin T.; Griffioen, Marieke; Horn, Peter; Sitek, Barbara; Beelen, Dietrich; Falkenburg, J.H.Frederik; Arrieta-Bolaños, Esteban; Fleischhauer, Katharina
    Permissive HLA-DPB1 mismatches in HCT depend on immunopeptidome divergence and editing by HLA-DM
    In: Blood Vol. 137 (2021) Nr. 7, pp. 923 - 928
    Online Full Text: dx.doi.org/ (Open Access)
  • Wagner, Bettina; Dührsen, Ulrich; Hüttmann, Andreas; Nückel, Holger; Michita, Rafael Tomoya; Rohn, Hana; Schramm, Sabine; Horn, Peter; Rebmann, Vera
    Genetic Variants of the NKG2C/HLA-E Receptor : Ligand Axis Are Determinants of Progression-Free Survival and Therapy Outcome in Aggressive B-Cell Lymphoma
    In: Cancers Vol. 12 (2020) Nr. 11, pp. 3429
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Metzenmacher, Martin; Váraljai, Renáta; Hegedüs, Balazs; Cima, Igor; Forster, Jan; Schramm, Alexander; Scheffler, Björn; Horn, Peter; Klein, Christoph A.; Szarvas, Tibor; Reis, Henning; Bielefeld, Nicola; Rösch, Alexander; Aigner, Clemens; Kunzmann, Volker; Wiesweg, Marcel; Siveke, Jens; Schuler, Martin; Lueong, Smiths S.
    Plasma next generation sequencing and droplet digital-qpcr-based quantification of circulating cell-free rna for noninvasive early detection of cancer
    In: Cancers Vol. 12 (2020) Nr. 2, pp. 353
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Schwich, Esther; Rebmann, Vera; Horn, Peter; Celik, Alexander A.; Bade-Döding, Christina; Kimmig, Rainer; Kasimir-Bauer, Sabine; Buderath, Paul
    Vesicular-Bound HLA-G as a Predictive Marker for Disease Progression in Epithelial Ovarian Cancer
    In: Cancers Vol. 11 (2019) Nr. 8, pp. 1106
    Online Full Text: dx.doi.org/ (Open Access)
  • Langer, Samantha K; Cull, Alyssa; Wossidlo, Natalie; Klump, Hannes; Horn, Peter; Heinrichs, Stefan;
    Distinct Gene Expression Patterns Drive Proliferation of Dominant-Negative RUNX1 Immortalized HSPCs
    60th ASH Annual Meeting; December 1-4, 2018; San Diego, USA,
    In: Blood Vol. 132 (2018) Nr. Supplement 1, pp. 1795 - 1795
    Online Full Text: dx.doi.org/ (Open Access)
  • König, Lisa; Rebmann, Vera; Hoffmann, Oliver; Bittner, A. K.; Wagner, B.; Manvailer, L. F. S.; Schramm, S.; Bankfalvi, Agnes; Giebel, Bernd; Kimmig, Rainer; Horn, Peter A.; Kasimir-Bauer, Sabine
    Breast cancer-derived extracellular vesicles : clinical and prognostic impact
    In: Cancer Research Vol. 76 (2016) Nr. 14 Suppl., pp. 3152
    Online Full Text: dx.doi.org/
  • Crivello, Pietro; Heinold, Andreas; Rebmann, Vera; Ottinger, Hellmut; Horn, Peter; Beelen, Dietrich; Fleischhauer, Katharina
    Functional distance between recipient and donor HLA-DPB1 determines nonpermissive mismatches in unrelated HCT
    In: Blood Vol. 128 (2016) Nr. 1, pp. 120 - 129
    Online Full Text: dx.doi.org/ (Open Access)
  • Beelen, Dietrich; Crivello, P.; Heinold, Andreas; Riebschlager, S.; Heinemann, Falko M.; Rebmann, Vera; Lindemann, Monika; Ottinger, Hellmut; Horn, Peter; Fleischhauer, Katharina
    The Functional Distance Between Mismatched HLA-DPB1 Increases Risks of Relapse and Mortality after Unrelated Donor Hematopoietic Cell Transplantation for AML, ALL and MDS : A Refinement of the T Cell Epitope Group Algorithm for Permissive Mismatches
    In: Blood Vol. 126 (2015) Nr. 23, pp. 4288
    Online Full Text
  • Skibbe, K.; Budeus, Bettina; Heinemann, Falko M.; Timmer, L.; Horn, Peter; van Esch, W.; Hoffmann, Daniel; Siemann, H.; Scherbaum, Norbert; Timm, Jörg
    HLA-B*27 is protective against HCV genotype 1 and 3 and associated with targeting of distinct genotype-specific CD8(+) cell epitopes
    In: Journal of Hepatology Vol. 60 (2014) Nr. Suppl. 1, pp. 140
    Online Full Text: dx.doi.org/
  • Kordelas, L; Rebmann, Vera; Ludwig, A-K; Radtke, Stefan; Ruesing, J; Döppner, Thorsten R.; Epple, Matthias; Horn, Peter; Beelen, Dietrich; Giebel, Bernd
    MSC-derived exosomes : a novel tool to treat therapy-refractory graft-versus-host disease
    In: Leukemia Vol. 28 (2014) Nr. 4, pp. 970 - 973
    Online Full Text: dx.doi.org/
  • Kordelas, Lambros; Verheyen, Jens; Beelen, Dietrich; Horn, Peter; Heinold, Andreas; Kaiser, Rolf; Trenschel, Rudolf; Schadendorf, Dirk; Dittmer, Ulf; Esser, Stefan
    Shift of HIV tropism in stem-cell transplantation with CCR5 Delta32 mutation
    In: The New England Journal of Medicine Vol. 371 (2014) Nr. 9, pp. 880 - 882
    Online Full Text: dx.doi.org/
  • Ziegler, Susanne; Ruhl, Marianne; Tenckhoff, Hannelore; Wiese, Manfred; Heinemann, Falko M.; Horn, Peter; Spengler, Ulrich; Neumann-Haefelin, Christoph; Nattermann, Jacob; Timm, Jörg
    Susceptibility to chronic hepatitis C virus infection is influenced by sequence differences in immunodominant CD8+ T cell epitopes
    In: Journal of Hepatology Vol. 58 (2013) Nr. 1, pp. 24 - 30
    Online Full Text: dx.doi.org/
  • Wagner, B.; Rebmann, Vera; May, T.; Dührsen, Ulrich; Gothert, J. R.; Horn, Peter; Opalka, B.
    AML Bone Marrow Microenvironment Impairs Dendritic Cell Maturation and Antigen Presentation
    In: Blood Vol. 120 (2012) Nr. 21, -
  • Ruhl, Marianne; Knuschke, Torben; Schewior, Kevin; Glavinic, Lejla; Neumann-Haefelin, Christoph; Chang, Dae-In; Klein, Marina; Heinemann, Falko M.; Tenckhoff, Hannelore; Wiese, Manfred; Horn, Peter A.; Viazov, Sergey; Spengler, Ulrich; Roggendorf, Michael; Scherbaum, Norbert; Nattermann, Jacob; Hoffmann, Daniel; Timm, Jörg; East German HCV Study Group
    CD8+ T-Cell Response Promotes Evolution of Hepatitis C Virus Nonstructural Proteins
    In: Gastroenterology Vol. 140 (2011) Nr. 7, pp. 2064 - 2073
    Online Full Text: dx.doi.org/
  • Elmaagacli, Ahmet Hayri; Steckel, Nina Kristin; Koldehoff, Michael; Hegerfeldt, Yael; Trenschel, Rudolf; Ditschkowski, Markus; Christoph, Sandra; Gromke, Tanja; Kordelas, Lambros; Ottinger, Hellmut; Roß, Rudolf Stefan; Horn, Peter; Schnittger, Susanne; Beelen, Dietrich
    Early human cytomegalovirus replication after transplantation is associated with a decreased relapse risk : evidence for a putative virus-versus-leukemia effect in acute myeloid leukemia patients
    In: Blood Vol. 118 (2011) Nr. 5, pp. 1402 - 1412
    Online Full Text: dx.doi.org/ (Open Access)
  • Johansson, Patricia; Maldonado de Dechene, E.; Eisele, Lewin; Kieruzel, Sabrina; Horn, Peter; Schmücker, U.; Vetter, Irina; Dührsen, Ulrich; Gerken, Guido; Dürig, Jan; Schlaak, Jörg Friedrich
    705 Increased prevalence of monoclonal b lymphocytosis in patients with chronic Hepatitis C
    In: Journal of Hepatology Vol. 52 (2010) Nr. Suppl. 1, pp. S274
    Online Full Text: dx.doi.org/
  • Nückel, Holger; Switala, Magdalena; Sellmann, Ludger; Horn, Peter; Dürig, Jan; Dührsen, Ulrich; Küppers, Ralf; Grosse-Wilde, Hans; Rebmann, Vera
    The prognostic significance of soluble NKG2D ligands in B-cell chronic lymphocytic leukemia
    In: Leukemia Vol. 24 (2010) Nr. 6, pp. 1152 - 1159
    Online Full Text: dx.doi.org/
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