ZMB member Björn Scheffler
ZMB Member
Björn Scheffler
Next ZMB-Member
Prof. Dr. Björn Scheffler
West German Cancer Center (WTZ)
German Cancer Research Center (DKFZ)
University Duisburg-Essen
45141 Essen
- +49 201 183 8131
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Oncology
Research Overview
We are an extramural Division of the German Cancer Research Center (DKFZ) in Heidelberg, set up as part of the German Cancer Consortium (DKTK) at the West German Cancer Center (WTZ) in Essen. The lab employs clinician scientists, medical scientists, students pursuing medical or biomedical degree programs, technicians and administrative staff. We conduct basic research in such a way that clinical applications for cancer therapy can be translated to patients as soon as possible. Most of our Wetlab protocols apply stem cell biology tools and patient-derived cancer cells. Current studies focus on
- phenotypic plasticity of treatment-resistant cancer cells
- the role of the immune system in the progression of cancer
- the development of new anticancer therapeutics
- establishing new biomarkers for predicting the clinical course of cancer and its response to therapy in early-phase clinical studies.
We primarily study oncogenic mechanisms related to human brain tumors and metastasized CNS disease; however, our translational approach enables validation of discoveries in any type of cancer. The research is interdisciplinary and is carried out in close collaboration with all clinical units providing neuro-oncology services at the University Hospital Essen and with many national and international collaborators from academia and industry.
Read moreSelected Publications
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Cranioencephalic functional lymphoid units in glioblastomaIn: Nature Medicine (2024) in pressOnline Full Text: dx.doi.org/ (Open Access)
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A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in GlioblastomaIn: Clinical Cancer Research Vol. 29 (2023) Nr. 2, pp. 488 - 500Online Full Text: dx.doi.org/ (Open Access)
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Individual glioblastoma cells harbor both proliferative and invasive capabilities during tumor progressionIn: Neuro-Oncology Vol. 25 (2023) Nr. 12, pp. 2150 - 2162Online Full Text: dx.doi.org/
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Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expressionIn: Nature Communications Vol. 13 (2022) Nr. 1, 156Online Full Text: dx.doi.org/ (Open Access)
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The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumorsIn: Nature Communications Vol. 13 (2022) Nr. 1, 4061Online Full Text: dx.doi.org/ (Open Access)
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Tumor-associated hematopoietic stem and progenitor cells positively linked to glioblastoma progressionIn: Nature Communications Vol. 12 (2021) Nr. 1, 3895Online Full Text: dx.doi.org/ (Open Access)
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3D extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumorsIn: Nature Communications Vol. 10 (2019) pp. 4529Online Full Text: dx.doi.org/ (Open Access)
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Functional Subclone profiling for prediction of treatment-induced intratumor population shifts and discovery of rational drug combinations in human glioblastomaIn: Clinical Cancer Research Vol. 23 (2017) Nr. 2, pp. 562 - 574Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Dynamic O-(2-[18F]fluoroethyl)-L-tyrosine PET imaging for the detection of checkpoint inhibitor-related pseudoprogression in melanoma brain metastasesIn: Neuro-Oncology Vol. 18 (2016) Nr. 10, pp. 1462 - 1464Online Full Text: dx.doi.org/
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Late Pseudoprogression in Glioblastoma : Diagnostic Value of Dynamic O-(2-[¹⁸ F]fluoroethyl)-L-Tyrosine PETIn: Clinical Cancer Research Vol. 22 (2016) Nr. 9, pp. 2190 - 2196Online Full Text: dx.doi.org/
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Anticancer effects of niclosamide in human glioblastomaIn: Clinical Cancer Research Vol. 19 (2013) Nr. 15, pp. 4124 - 4136Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotypeIn: Proceedings of the National Academy of Sciences of the United States of America Vol. 108 (2011) Nr. 24, pp. 9951 - 9956Online Full Text: dx.doi.org/ (Open Access)
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Residual tumor cells are unique cellular targets in glioblastomaIn: Annals of Neurology Vol. 68 (2010) Nr. 2, pp. 264 - 269Online Full Text: dx.doi.org/ (Open Access)
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Temporally restricted substrate interactions direct fate and specification of neural precursors derived from embryonic stem cellsIn: Proceedings of the National Academy of Sciences of the United States of America Vol. 103 (2006) Nr. 29, pp. 11063 - 11068Online Full Text: dx.doi.org/ (Open Access)
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Functional integration of embryonic stem cell-derived neurons in hippocampal slice culturesIn: Journal of Neuroscience Vol. 23 (2003) Nr. 18, pp. 7075 - 7083Online Full Text: dx.doi.org/ (Open Access)