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ZMB member Björn Scheffler

ZMB Member
Björn Scheffler

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Björn Scheffler
© Scheffler/Lange/punktbar

Prof. Dr. Björn Scheffler

Group

Translational Neurooncology

West German Cancer Center (WTZ)
German Cancer Research Center (DKFZ)
University Duisburg-Essen
45141 Essen

Research Overview

We are an extramural Division of the German Cancer Research Center (DKFZ) in Heidelberg, set up as part of the German Cancer Consortium (DKTK) at the West German Cancer Center (WTZ) in Essen. The lab employs clinician scientists, medical scientists, students pursuing medical or biomedical degree programs, technicians and administrative staff. We conduct basic research in such a way that clinical applications for cancer therapy can be translated to patients as soon as possible. Most of our Wetlab protocols apply stem cell biology tools and patient-derived cancer cells. Current studies focus on

  1. phenotypic plasticity of treatment-resistant cancer cells
  2. the role of the immune system in the progression of cancer
  3. the development of new anticancer therapeutics
  4. establishing new biomarkers for predicting the clinical course of cancer and its response to therapy in early-phase clinical studies.

We primarily study oncogenic mechanisms related to human brain tumors and metastasized CNS disease; however, our translational approach enables validation of discoveries in any type of cancer. The research is interdisciplinary and is carried out in close collaboration with all clinical units providing neuro-oncology services at the University Hospital Essen and with many national and international collaborators from academia and industry.

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Selected Publications

    Journal articles

  • Dobersalske, Celia; Rauschenbach, Laurèl; Hua, Yichao; Berliner, Christoph; Steinbach, Anita; Grüneboom, Anika; Kokkaliaris, Konstantinos D.; Heiland, Dieter H.; Berger, Pia; Langer, Sarah; Tan, Chin L.; Stenzel, Martin; Landolsi, Somaya; Weber, Flora; Dar et al.
    Cranioencephalic functional lymphoid units in glioblastoma
    In: Nature Medicine Vol. 30 (2024) Nr. 10, pp. 2947 - 2956
    Online Full Text: dx.doi.org/ (Open Access)
  • Kebir, Sied; Ullrich, Vivien; Berger, Pia; Dobersalske, Celia; Langer, Sarah; Rauschenbach, Laurèl; Trageser, Daniel; Till, Andreas; Lorbeer, Franziska K.; Wieland, Anja; Wilhelm-Buchstab, Timo; Ahmad, Ashar; Fröhlich, Holger; Cima, Igor; Prasad, Shruthi; et al.
    A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma
    In: Clinical Cancer Research Vol. 29 (2023) Nr. 2, pp. 488 - 500
    Online Full Text: dx.doi.org/ (Open Access)
  • Ratliff, Miriam; Karimian-Jazi, Kianush; Hoffmann, Dirk C; Rauschenbach, Laurèl; Simon, Matthias; Hai, Ling; Mandelbaum, Henriette; Schubert, Marc C; Kessler, Tobias; Uhlig, Stefanie; Dominguez Azorin, Daniel; Jung, Erik; Osswald, Matthias; Solecki, Gergel et al.
    Individual glioblastoma cells harbor both proliferative and invasive capabilities during tumor progression
    In: Neuro-Oncology Vol. 25 (2023) Nr. 12, pp. 2150 - 2162
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Cheung, Phyllis F.; Yang, JiaJin; Fang, Rui; Borgers, Arianna; Krengel, Kirsten; Stoffel, Anne; Althoff, Kristina; Yip, Chi Wai; Siu, Elaine H. L.; Ng, Linda W. C.; Lang, Karl S.; Cham, Lamin B.; Engel, Daniel Robert; Soun, Camille; Cima, Igor; Scheffler, et al.
    Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression
    In: Nature Communications Vol. 13 (2022) Nr. 1, 156
    Online Full Text: dx.doi.org/ (Open Access)
  • Bartl, Jasmin; Zanini, Marco; Bernardi, Flavia; Forget, Antoine; Blümel, Lena; Talbot, Julie; Picard, Daniel; Qin, Nan; Cancila, Gabriele; Gao, Qingsong; Nath, Soumav; Koumba, Idriss Mahoungou; Wolter, Marietta; Kuonen, François; Langini, Maike; Beez, Thom et al.
    The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors
    In: Nature Communications Vol. 13 (2022) Nr. 1, 4061
    Online Full Text: dx.doi.org/ (Open Access)
  • Lu, I-Na; Dobersalske, Celia; Rauschenbach, Laurèl; Teuber-Hanselmann, Sarah; Steinbach, Anita; Ullrich, Vivien; Prasad, Shruthi; Blau, Tobias; Kebir, Sied; Siveke, Jens; Becker, Jürgen; Sure, Ulrich; Glas, Martin; Scheffler, Björn; Cima, Igor.
    Tumor-associated hematopoietic stem and progenitor cells positively linked to glioblastoma progression
    In: Nature Communications Vol. 12 (2021) Nr. 1, 3895
    Online Full Text: dx.doi.org/ (Open Access)
  • Sood, Disha; Tang-Schomer, Min; Pouli, Dimitra; Mizzoni, Craig; Raia, Nicole; Tai, Albert; Arkun, Knarik; Wu, Julian; Black, Lauren D.; Scheffler, Björn; Georgakoudi, Irene; Steindler, Dennis A.; Kaplan, David L.
    3D extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumors
    In: Nature Communications Vol. 10 (2019) pp. 4529
    Online Full Text: dx.doi.org/ (Open Access)
  • Reinartz, Roman; Wang, Shanshan; Kebir, Sied; Silver, Daniel J.; Wieland, Anja; Zheng, Tong; Kupper, Marius; Rauschenbach, Laurel; Fimmers, Rolf; Shepherd, Timothy M.; Trageser, Daniel; Till, Andreas; Schafer, Niklas; Glas, Martin; Hillmer, Axel M.; Cichon et al.
    Functional Subclone profiling for prediction of treatment-induced intratumor population shifts and discovery of rational drug combinations in human glioblastoma
    In: Clinical Cancer Research Vol. 23 (2017) Nr. 2, pp. 562 - 574
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Kebir, Sied; Rauschenbach, Laurèl; Galldiks, Norbert; Schlaak, Max; Hattingen, Elke; Landsberg, Jennifer; Bundschuh, Ralph A.; Langen, Karl-Josef; Scheffler, Björn; Herrlinger, Ulrich; Glas, Martin.
    Dynamic O-(2-[18F]fluoroethyl)-L-tyrosine PET imaging for the detection of checkpoint inhibitor-related pseudoprogression in melanoma brain metastases
    In: Neuro-Oncology Vol. 18 (2016) Nr. 10, pp. 1462 - 1464
    Online Full Text: dx.doi.org/
  • Kebir, Sied; Fimmers, Rolf; Galldiks, Norbert; Schafer, Niklas; Mack, Frederic; Schaub, Christina; Stuplich, Moritz; Niessen, Michael; Tzaridis, Theophilos; Simon, Matthias; Stoffels, Gabriele; Langen, Karl-Josef; Scheffler, Bjorn; Glas, Martin; Herrlinger et al.
    Late Pseudoprogression in Glioblastoma : Diagnostic Value of Dynamic O-(2-[¹⁸ F]fluoroethyl)-L-Tyrosine PET
    In: Clinical Cancer Research Vol. 22 (2016) Nr. 9, pp. 2190 - 2196
    Online Full Text: dx.doi.org/
  • Wieland, Anja; Trageser, Daniel; Gogolok, Sabine; Reinartz, Roman; Höfer, Heike; Keller, Mihaela; Leinhaas, Anke; Schelle, Ramona; Normann, Sabine; Klaas, Lil; Waha, Andreas; Koch, Philipp; Fimmers, Rolf; Pietsch, Torsten; Yachnis, Anthony T.; Pincus, Davi et al.
    Anticancer effects of niclosamide in human glioblastoma
    In: Clinical Cancer Research Vol. 19 (2013) Nr. 15, pp. 4124 - 4136
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Glas, Martin; Rath, Barbara H.; Simon, Matthias; Reinartz, Roman; Schramme, Anja; Trageser, Daniel; Eisenreich, Ramona; Leinhaas, Anke; Keller, Mihaela; Schildhaus, Hans-Ulrich; Garbe, Stephan; Steinfarz, Barbara; Pietsch, Torsten; Steindler, Dennis A.; Sc et al.
    Residual tumor cells are unique cellular targets in glioblastoma
    In: Annals of Neurology Vol. 68 (2010) Nr. 2, pp. 264 - 269
    Online Full Text: dx.doi.org/ (Open Access)
  • Goetz, A. Katrin; Scheffler, Björn; Chen, Huan-Xin; Wang, Shanshan; Suslov, Oleg; Xiang, Hui; Brüstle, Oliver; Roper, Steve N.; Steindler, Dennis A.; Chen, H.-X.
    Temporally restricted substrate interactions direct fate and specification of neural precursors derived from embryonic stem cells
    In: Proceedings of the National Academy of Sciences of the United States of America Vol. 103 (2006) Nr. 29, pp. 11063 - 11068
    Online Full Text: dx.doi.org/ (Open Access)
  • Benninger, Felix; Beck, Heinz; Wernig, Marius; Tucker, Kerry L.; Brüstle, Oliver; Scheffler, Björn.
    Functional integration of embryonic stem cell-derived neurons in hippocampal slice cultures
    In: Journal of Neuroscience Vol. 23 (2003) Nr. 18, pp. 7075 - 7083
    Online Full Text: dx.doi.org/ (Open Access)
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