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ZMB Member Christoph Kleinschnitz

ZMB Member
Christoph Kleinschnitz

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Christoph Kleinschnitz portrait
© Martin Kaiser/UK Essen

Prof. Dr. Christoph Kleinschnitz

Director of:

Clinic for Neurology

University Hospital Essen
Hufelandstr. 55
45147 Essen

Research Overview

  • Peripheral Nervous System Disorders
  • Clinical and experimental neuroimmunology
  • Clinical stroke research
  • Headache and dizziness
  • Multiple sclerosis/neuroimmunology
  • Thrombo-inflammation
  • Clinical neuro-oncology

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Selected Publications

    Journal articles

  • Meuth, Sven G.; Wolff, Stephanie; Mück, Anna; Willison, Alice; Kleinschnitz, Konstanze; Räuber, Saskia; Pawlitzki, Marc; Konen, Franz Felix; Skripuletz, Thomas; Grothe, Matthias; Ruck, Tobias; Huttner, Hagen B.; Kleinschnitz, Christoph; Bopp, Tobias; Pul, et al.
    Different Treatment Outcomes of Multiple Sclerosis Patients Receiving Ocrelizumab or Ofatumumab
    In: Annals of Neurology Vol. 97 (2025) Nr. 3, pp. 583 - 595
    Online Full Text: dx.doi.org/ (Open Access)
  • Roos, Andreas; Schmitt, Linda-Isabell; Hansmann, Christina; Hezel, Stefanie; Salmanian, Schahin; Hentschel, Andreas; Meyer, Nancy; Della Marina, Adela; Kölbel, Heike; Kleinschnitz, Christoph; Schara-Schmidt, Ulrike; Leo, Markus; Hagenacker, Tim.
    Alteration of LARGE1 abundance in patients and a mouse model of 5q-associated spinal muscular atrophy
    In: Acta Neuropathologica Vol. 147 (2024) Nr. 1, 53
    Online Full Text: dx.doi.org/ (Open Access)
  • Lu, I-Na; Cheung, Phyllis Fung-Yi; Heming, Michael; Thomas, Christian; Giglio, Giovanni; Leo, Markus; Erdemir, Merve; Wirth, Timo; König, Simone; Dambietz, Christine A.; Schroeter, Christina B.; Nelke, Christopher; Siveke, Jens T.; Ruck, Tobias; Klotz, Lui et al.
    Cell-mediated cytotoxicity within CSF and brain parenchyma in spinal muscular atrophy unaltered by nusinersen treatment
    In: Nature Communications Vol. 15 (2024) Nr. 1, 4120
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Schmitt, Linda-Isabell; David, Christina; Steffen, Rebecca; Hezel, Stefanie; Roos, Andreas; Schara-Schmidt, Ulrike; Kleinschnitz, Christoph; Leo, Markus; Hagenacker, Tim.
    Spinal astrocyte dysfunction drives motor neuron loss in late-onset spinal muscular atrophy
    In: Acta Neuropathologica Vol. 145 (2023) Nr. 5, pp. 611 - 635
    Online Full Text: dx.doi.org/ (Open Access)
  • Feldheim, Jonas; Schmidt, Teresa; Oster, Christoph; Feldheim, Julia; Stuschke, Martin; Stummer, Walter; Grauer, Oliver; Scheffler, Björn; Hagemann, Carsten; Sure, Ulrich; Kleinschnitz, Christoph; Lazaridis, Lazaros; Kebir, Sied; Glas, Martin.
    Telemedicine in Neuro-Oncology : An Evaluation of Remote Consultations during the COVID-19 Pandemic
    In: Cancers Vol. 15 (2023) Nr. 16, 4054
    Online Full Text: dx.doi.org/ (Open Access)
  • Rohlfing, Anne-Katrin; Kolb, Kyra; Sigle, Manuel; Ziegler, Melanie; Bild, Alexander; Münzer, Patrick; Sudmann, Jessica; Dicenta, Valerie; Harm, Tobias; Manke, Mailin-Christin; Geue, Sascha; Kremser, Marcel; Chatterjee, Madhumita; Liang, Chunguang; von Eysm et al.
    ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury
    In: Nature Communications Vol. 13 (2022) Nr. 1, 1823
    Online Full Text: dx.doi.org/ (Open Access)
  • Obermann, Mark; Nägel, Steffen; Ose, Claudia; Sonuc, Nilüfer; Scherag, Andre; Storch, Peter; Gaul, Charly; Böger, Andreas; Kraya, Torsten; Jansen, Jan-Peter; Straube, Andreas; Freilinger, Tobias; Kaube, Holger; Jürgens, Tim P; Diener, Hans Christoph; Katsa et al.
    Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache : A multicentre, double-blind, randomised controlled trial
    In: The Lancet Neurology Vol. 20 (2021) Nr. 1, pp. 29 - 37
    Online Full Text: dx.doi.org/
  • Kebir, Sied; Schmidt, Teresa; Weber, Matthias; Lazaridis, Lazaros; Galldiks, Norbert; Langen, Karl-Josef; Kleinschnitz, Christoph; Hattingen, Elke; Herrlinger, Ulrich; Lohmann, Philipp; Glas, Martin.
    A preliminary study on machine learning-based evaluation of static and dynamic fet-pet for the detection of pseudoprogression in patients with idh-wildtype glioblastoma
    In: Cancers Vol. 12 (2020) Nr. 11, pp. 3080
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Hagenacker, Tim; Wurster, Claudia D.; Günther, René; Schreiber-Katz, Olivia; Osmanovic, Alma; Petri, Susanne; Weiler, Markus; Ziegler, Andreas; Kuttler, Josua; Koch, Jan C.; Schneider, Ilka; Wunderlich, Gilbert; Schloss, Natalie; Lehmann, Helmar C.; Cordts et al.
    Nusinersen in adults with 5q spinal muscular atrophy : A non-interventional, multicentre, observational cohort study
    In: The Lancet Neurology Vol. 19 (2020) Nr. 4, pp. 317 - 325
    Online Full Text: dx.doi.org/
  • Szepanowski, Fabian; Szepanowski, Leon-Phillip; Mausberg, Anne K.; Albrecht, Philipp; Kleinschnitz, Christoph; Kieseier, Bernd C.; Stettner, Mark.
    Differential impact of pure glyphosate and glyphosate-based herbicide in a model of peripheral nervous system myelination
    In: Acta Neuropathologica Vol. 136 (2018) Nr. 6, pp. 979 - 982
    Online Full Text: dx.doi.org/
  • Sauter, Reinhard J.; Sauter, Manuela; Reis, Edimara S.; Emschermann, Frederic N.; Nording, Henry; Ebenhöch, Sonja; Kraft, Peter; Münzer, Patrick; Mauler, Maximilian; Rheinlaender, Johannes; Madlung, Johannes; Edlich, Frank; Schäffer, Tilman E.; Meuth, Sven et al.
    Functional relevance of the anaphylatoxin receptor C3aR for platelet function and arterial thrombus formation marks an intersection point between innate immunity and thrombosis
    In: Circulation Vol. 138 (2018) Nr. 16, pp. 1720 - 1735
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Münzer, Patrick; Walker-Allgaier, Britta; Geue, Sascha; Langhauser, Friederike; Geuss, Eva; Stegner, David; Aurbach, Katja; Semeniak, Daniela; Chatterjee, Madhumita; Menendez, Irene Gonzalez; Märklin, Melanie; Quintanilla-Martinez, Leticia; Salih, Helmut R et al.
    CK2b regulates thrombopoiesis and Ca21-Triggered platelet activation in arterial thrombosis
    In: Blood Vol. 130 (2017) Nr. 25, pp. 2774 - 2785
    Online Full Text: dx.doi.org/
  • Szepanowski, Fabian; Donaldson, Daniel M.; Hartung, Hans-Peter; Mausberg, Anne K.; Kleinschnitz, Christoph; Kieseier, Bernd C.; Stettner, Mark.
    Dimethyl fumarate accelerates peripheral nerve regeneration via activation of the anti-inflammatory and cytoprotective Nrf2/HO-1 signaling pathway
    In: Acta Neuropathologica Vol. 133 (2017) Nr. 3, pp. 489 - 491
    Online Full Text: dx.doi.org/
  • Fluri, Felix; Malzahn, Uwe; Homola, György A.; Schuhmann, Michael K.; Kleinschnitz, Christoph; Volkmann, Jens.
    Stimulation of the mesencephalic locomotor region for gait recovery after stroke
    In: Annals of Neurology Vol. 82 (2017) Nr. 5, pp. 828 - 840
    Online Full Text: dx.doi.org/
  • Bieber, Michael; Werner, Rudolf A.; Tanai, Edit; Hofmann, Ulrich; Higuchi, Takahiro; Schuh, Kai; Heuschmann, Peter U.; Frantz, Stefan; Ritter, Oliver; Kraft, Peter; Kleinschnitz, Christoph.
    Stroke-induced chronic systolic dysfunction driven by sympathetic overactivity
    In: Annals of Neurology Vol. 82 (2017) Nr. 5, pp. 729 - 743
    Online Full Text: dx.doi.org/ (Open Access)
  • Denorme, Frederik; Langhauser, Friederike; Desender, Linda; Vandenbulcke, Aline; Rottensteiner, Hanspeter; Plaimauer, Barbara; François, Olivier; Andersson, Tommy; Deckmyn, Hans; Scheiflinger, Friedrich; Kleinschnitz, Christoph; Vanhoorelbeke, Karen; De Me et al.
    ADAMTS13-mediated thrombolysis of t-PA-resistant occlusions in ischemic stroke in mice
    In: Blood Vol. 127 (2016) Nr. 19, pp. 2337 - 2345
    Online Full Text: dx.doi.org/
  • Göbel, Kerstin; Pankratz, Susann; Asaridou, Chloi-Magdalini; Herrmann, Alexander M; Bittner, Stefan; Merker, Monika; Ruck, Tobias; Glumm, Sarah; Langhauser, Friederike; Kraft, Peter; Krug, Thorsten F; Breuer, Johanna; Herold, Martin; Gross, Catharina C; Be et al.
    Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells
    In: Nature Communications Vol. 7 (2016) pp. 11626
    Online Full Text: dx.doi.org/ (Open Access)
  • Göbel, Kerstin; Kraft, Peter; Pankratz, Susann; Gross, Catharina C.; Korsukewitz, Catharina; Kwiecien, Robert; Mesters, Rolf; Kehrel, Beate E.; Wiendl, Heinz; Kleinschnitz, Christoph; Meuth, Sven G.
    Prothrombin and factor X are elevated in multiple sclerosis patients
    In: Annals of Neurology Vol. 80 (2016) Nr. 6, pp. 946 - 951
    Online Full Text: dx.doi.org/
  • Hopp, Sarah; Albert-Weissenberger, Christiane; Mencl, Stine; Bieber, Michael; Schuhmann, Michael K; Stetter, Christian; Nieswandt, Bernhard; Schmidt, Peter M; Monoranu, Camelia-Maria; Alafuzoff, Irina; Marklund, Niklas; Nolte, Marc W; Sirén, Anna-Leena; Kl et al.
    Targeting coagulation factor XII as a novel therapeutic option in brain trauma
    In: Annals of Neurology Vol. 79 (2016) Nr. 6, pp. 970 - 982
    Online Full Text: dx.doi.org/ (Open Access)