ZMB Member Christoph Kleinschnitz
ZMB Member
Christoph Kleinschnitz
Next ZMB-Member
Prof. Dr. Christoph Kleinschnitz
Director of:
Clinic for Neurology
University Hospital Essen
Hufelandstr. 55
45147 Essen
- +49 201 723 246 0
- Website
- Selected Publications
- Publication Metrics
- ZMB Research Program
Molecular and Chemical Cell Biology
Research Overview
- Peripheral Nervous System Disorders
- Clinical and experimental neuroimmunology
- Clinical stroke research
- Headache and dizziness
- Multiple sclerosis/neuroimmunology
- Thrombo-inflammation
- Clinical neuro-oncology
Selected Publications
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Alteration of LARGE1 abundance in patients and a mouse model of 5q-associated spinal muscular atrophyIn: Acta Neuropathologica Vol. 147 (2024) Nr. 1, 53Online Full Text: dx.doi.org/ (Open Access)
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Cell-mediated cytotoxicity within CSF and brain parenchyma in spinal muscular atrophy unaltered by nusinersen treatmentIn: Nature Communications Vol. 15 (2024) Nr. 1, 4120Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Spinal astrocyte dysfunction drives motor neuron loss in late-onset spinal muscular atrophyIn: Acta Neuropathologica Vol. 145 (2023) Nr. 5, pp. 611 - 635Online Full Text: dx.doi.org/ (Open Access)
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Telemedicine in Neuro-Oncology : An Evaluation of Remote Consultations during the COVID-19 PandemicIn: Cancers Vol. 15 (2023) Nr. 16, 4054Online Full Text: dx.doi.org/ (Open Access)
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ACKR3 regulates platelet activation and ischemia-reperfusion tissue injuryIn: Nature Communications Vol. 13 (2022) Nr. 1, 1823Online Full Text: dx.doi.org/ (Open Access)
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Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache : A multicentre, double-blind, randomised controlled trialIn: The Lancet Neurology Vol. 20 (2021) Nr. 1, pp. 29 - 37Online Full Text: dx.doi.org/
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A preliminary study on machine learning-based evaluation of static and dynamic fet-pet for the detection of pseudoprogression in patients with idh-wildtype glioblastomaIn: Cancers Vol. 12 (2020) Nr. 11, pp. 3080Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Nusinersen in adults with 5q spinal muscular atrophy : A non-interventional, multicentre, observational cohort studyIn: The Lancet Neurology Vol. 19 (2020) Nr. 4, pp. 317 - 325Online Full Text: dx.doi.org/
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Differential impact of pure glyphosate and glyphosate-based herbicide in a model of peripheral nervous system myelinationIn: Acta Neuropathologica Vol. 136 (2018) Nr. 6, pp. 979 - 982Online Full Text: dx.doi.org/
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Functional relevance of the anaphylatoxin receptor C3aR for platelet function and arterial thrombus formation marks an intersection point between innate immunity and thrombosisIn: Circulation Vol. 138 (2018) Nr. 16, pp. 1720 - 1735Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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CK2b regulates thrombopoiesis and Ca21-Triggered platelet activation in arterial thrombosisIn: Blood Vol. 130 (2017) Nr. 25, pp. 2774 - 2785Online Full Text: dx.doi.org/
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Dimethyl fumarate accelerates peripheral nerve regeneration via activation of the anti-inflammatory and cytoprotective Nrf2/HO-1 signaling pathwayIn: Acta Neuropathologica Vol. 133 (2017) Nr. 3, pp. 489 - 491Online Full Text: dx.doi.org/
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Stimulation of the mesencephalic locomotor region for gait recovery after strokeIn: Annals of Neurology Vol. 82 (2017) Nr. 5, pp. 828 - 840Online Full Text: dx.doi.org/
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Stroke-induced chronic systolic dysfunction driven by sympathetic overactivityIn: Annals of Neurology Vol. 82 (2017) Nr. 5, pp. 729 - 743Online Full Text: dx.doi.org/ (Open Access)
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ADAMTS13-mediated thrombolysis of t-PA-resistant occlusions in ischemic stroke in miceIn: Blood Vol. 127 (2016) Nr. 19, pp. 2337 - 2345Online Full Text: dx.doi.org/
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Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cellsIn: Nature Communications Vol. 7 (2016) pp. 11626Online Full Text: dx.doi.org/ (Open Access)
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Prothrombin and factor X are elevated in multiple sclerosis patientsIn: Annals of Neurology Vol. 80 (2016) Nr. 6, pp. 946 - 951Online Full Text: dx.doi.org/
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Targeting coagulation factor XII as a novel therapeutic option in brain traumaIn: Annals of Neurology Vol. 79 (2016) Nr. 6, pp. 970 - 982Online Full Text: dx.doi.org/ (Open Access)