ZMB Member Shirley Knauer
ZMB Member
Shirley Knauer
Next ZMB-Member
Prof. Dr. Shirley Knauer
Group
Molecular Biology IIFaculty of Biology
University Duisburg-Essen
45141 Essen
- +49 201 183 4987
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- Selected Publications
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- ZMB Research Program
Molecular and Chemical Cell Biology
Research Overview
Our research interests focus on molecular and translational clinical oncology as well as on the biomedical transfer of the compiled results. They aim on a detailed understanding of the regulation of nucleo-cytoplasmic transport processes, their impact on malignant transformation in cancer development, the discovery of novel therapeutic targets as well as the establishment of novel drug-screening assays.
Current projects concentrate on the molecular and pathophysiological function of the "Inhibitor of Apoptosis" protein Survivin, which is attributed a decisive role in the development of cancer and other diseases.
Using corroborating experimental approaches including microinjection experiments, flourescence as well as confocal microscopy, we could demonstrate that Survivin is actively exported from the cell nucleus. This transport process was not only a prerequisite for protection of cancer cells against radio- and chemotherapy by Survivin, but also plays a causal role in the treatment response of cancer patients. Therefore, targeted interference with the nuclear export of survivin by molecular decoys seems to be a highly promising innovative strategy to impede growth and therapy resistance of cancer cells. Additionally, the detailed functional characterisation of the anti-apoptotic protein Survivin and its cellular transport activity led to novel groundbreaking insights concerning the essential involvement of transport receptors in mitotic processes.
Read moreSelected Publications
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GGDEF domain as spatial on-switch for a phosphodiesterase by interaction with landmark protein HubPIn: npj Biofilms and Microbiomes Vol. 8 (2022) Nr. 1, 35Online Full Text: dx.doi.org/ (Open Access)
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The Taspase1/Myosin1f-axis regulates filopodia dynamicsIn: iScience Vol. 25 (2022) Nr. 6, 104355Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezersIn: Nature Communications Vol. 12 (2021) Nr. 1, pp. 1505Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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A Supramolecular Stabilizer of the 14-3-3ζ/ERα Protein-Protein Interaction with a Synergistic Mode of ActionIn: Angewandte Chemie International Edition Vol. 132 (2020) Nr. 13, pp. 5322 - 5325Online Full Text: dx.doi.org/ (Open Access)
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Erratum : Nanoparticle binding attenuates the pathobiology of gastric cancer-associated: Helicobacter pyloriIn: Nanoscale Vol. 12 (2020) Nr. 3, pp. 2154 - 2155Online Full Text: dx.doi.org/ (Open Access)
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Functional Disruption of the Cancer-Relevant Interaction between Survivin and Histone H3 with a Guanidiniocarbonyl Pyrrole LigandIn: Angewandte Chemie International Edition Vol. 59 (2020) Nr. 14, pp. 5567 - 5571Online Full Text: dx.doi.org/ (Open Access)
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The other side of the corona : Nanoparticles inhibit the protease taspase1 in a size-dependent mannerIn: Nanoscale Vol. 12 (2020) Nr. 37, pp. 19093 - 19103Online Full Text: dx.doi.org/
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Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing : Implications for the design of improved nanoantibioticsIn: Biomaterials Vol. 192 (2019) pp. 551 - 559Online Full Text: dx.doi.org/
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Nanomaterial-microbe cross-talk : physicochemical principles and (patho)biological consequencesIn: Chemical Society Reviews Vol. 47 (2018) Nr. 14, pp. 5312 - 5337Online Full Text: dx.doi.org/
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Nanoparticle binding attenuates the pathobiology of gastric cancer-associated Helicobacter pyloriIn: Nanoscale Vol. 10 (2018) Nr. 3, pp. 1453 - 1463Online Full Text: dx.doi.org/
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Efficient Gene Transfection through Inhibition of β-Sheet (Amyloid Fiber) Formation of a Short Amphiphilic Peptide by Gold NanoparticlesIn: Angewandte Chemie International Edition Vol. 56 (2017) Nr. 28, pp. 8083 - 8088Online Full Text: dx.doi.org/
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Morphology-Dependent Cell Imaging by Using a Self-Assembled Diacetylene Peptide AmphiphileIn: Angewandte Chemie International Edition Vol. 56 (2017) Nr. 46, pp. 14526 - 14530Online Full Text: dx.doi.org/
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Incorporation of a Non-Natural Arginine Analogue into a Cyclic Peptide Leads to Formation of Positively Charged Nanofibers Capable of Gene TransfectionIn: Angewandte Chemie International Edition Vol. 55 (2016) Nr. 2, pp. 598 - 601Online Full Text: dx.doi.org/
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A Tailor-Made Specific Anion-Binding Motif in the Side Chain Transforms a Tetrapeptide into an Efficient Vector for Gene DeliveryIn: Angewandte Chemie International Edition Vol. 54 (2015) Nr. 10, pp. 2941 - 2944Online Full Text: dx.doi.org/
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The nanoparticle biomolecule corona : lessons learned – challenge accepted?In: Chemical Society Reviews Vol. 44 (2015) Nr. 17, pp. 6094 - 6121Online Full Text: dx.doi.org/ (Open Access)
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Quantitative profiling of the protein coronas that form around nanoparticlesIn: Nature Protocols Vol. 9 (2014) Nr. 9, pp. 2030 - 2044Online Full Text: dx.doi.org/
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Rapid formation of plasma protein corona critically affects nanoparticle pathophysiologyIn: Nature Nanotechnology Vol. 8 (2013) Nr. 10, pp. 772 - 781Online Full Text: dx.doi.org/
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SIAH proteins : Critical roles in leukemogenesisIn: Leukemia Vol. 27 (2013) Nr. 4, pp. 792 - 802Online Full Text: dx.doi.org/
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Utilizing Combinatorial Chemistry and Rational Design : Peptidic Tweezers with Nanomolar Affinity to DNA Can Be Transformed into Efficient Vectors for Gene Delivery by Addition of a Lipophilic TailIn: Angewandte Chemie International Edition Vol. 52 (2013) Nr. 52, pp. 14016 - 14020Online Full Text: dx.doi.org/
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The heterodimerization domains of MLL-FYRN and FYRC-are potential target structures in t(4;11) leukemia.In: Leukemia Vol. 25 (2011) Nr. 4, pp. 663 - 670Online Full Text: dx.doi.org/
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The Survivin-Crm1 interaction is essential for chromosomal passenger complex localization and function.In: EMBO Reports Vol. 7 (2006) Nr. 12, pp. 1259 - 1265