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Faculty of Biology

Selected Publications

Prof. Dr.Peter Bayer

Group: Structural and Medicinal Biochemistry

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Prof. Dr.Dominik Boos

Group: Molecular Genetics II

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Prof. Dr.Michael Ehrmann

Group: Microbiology

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Prof. Dr.Doris Hellerschmied-Jelinek

Group: Mechanistic Cell Biology

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Prof. Dr.Daniel Hoffmann

Group: Bioinformatics and Computational Biophysics

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Prof. Dr. Dr. h.c. mult.Robert Huber

Group: Structure Research

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Prof. Dr.Christian Johannes

Group: Molecular Genetics I

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Prof. Dr.Markus Kaiser

Group: Chemical Biology

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Dr.Farnusch Kaschani

Manager of: Analytics Core Facility Essen (ACE)

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Prof. Dr.Shirley Knauer

Group: Molecular Biology II

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Prof. Dr.Hemmo Meyer

Group: Molecular Biology I

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Prof. Dr.Andrea Musacchio

Group: Mechanistic Cell Biology

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Prof. Dr.Perihan Nalbant

Group: Molecular Cell Biology

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Prof. Dr.Barbara Saccà

Group: Bionanotechnology

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Dr.Nina Schulze

Manager of: Imaging Center Essen (ICCE)

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Prof. Dr.Andrea Vortkamp

Group: Developmental Biology

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Prof. Dr.Stefan Westermann

Group: Molecular Genetics I

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Dr.Manuela Wülling

Group: Developmental Biology

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Selected Publications

    2024

  • Kück, Anja; van den Boom, Johannes; Koska, Sandra; Ron, David; Meyer, Hemmo
    Alternating binding and p97-mediated dissociation of SDS22 and I3 recycles active PP1 between holophosphatases
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 121 (2024) Nr. 36, e2408787121
    Online Full Text: dx.doi.org/ (Open Access)
  • Conti, Duccio; Verza, Arianna Esposito; Pesenti, Marion E.; Cmentowski, Verena; Vetter, Ingrid R.; Pan, Dongqing; Musacchio, Andrea
    Role of protein kinase PLK1 in the epigenetic maintenance of centromeres
    In: Science Vol. 385 (2024) Nr. 6713, pp. 1091 - 1097
    Online Full Text: dx.doi.org/
  • Lim, Wei Ming; Chew, Wei-Xiang; Esposito Verza, Arianna; Pesenti, Marion; Musacchio, Andrea; Surrey, Thomas
    Regulation of minimal spindle midzone organization by mitotic kinases
    In: Nature Communications Vol. 15 (2024) Nr. 1, 9213
    Online Full Text: dx.doi.org/ (Open Access)
  • Schwarz, Tatjana; Ptok, Johannes; Damagnez, Maximilian; Menne, Christopher; Alizei, Elahe Salimi; Lang-Meli, Julia; Maas, Michelle; Habermann, Daniel; Hoffmann, Daniel; Schulze zur Wiesch, Julian; Lauer, Georg; Kefalakes, Helenie; Cornberg, Markus; Kraft, Anke RM.; Gliga, Smaranda; Bock, Hans H.; Horn, Peter A.; Maini, Mala K.; Thimme, Robert; Wedemeyer, Heiner; Nattermann, Jacob; Heinemann, Falko M.; Luedde, Tom; Neumann-Haefelin, Christoph; Walker, Andreas; Timm, Jörg
    HBV shows different levels of adaptation to HLA class I-associated selection pressure correlating with markers of replication
    In: Journal of Hepatology (2024) in press
    Online Full Text: dx.doi.org/ (Open Access)
  • Beaufort, Nathalie; Ingendahl, Linda; Merdanovic, Melisa; Schmidt, Andree; Podlesainski, David; Richter, Tim; Neumann, Thorben; Kuszner, Michael; Vetter, Ingrid R.; Stege, Patricia; Burston, Steven G.; Filipovic, Anto; Ruiz-Blanco, Yasser B.; Bravo Rodriguez, Kenny; Mieres-Perez, Joel; Beuck, Christine; Uebel, Stephan; Zobawa, Monika; Schillinger, Jasmin; Malik, Rainer; Todorov-Völgyi, Katalin; Rey, Juliana; Roberti, Annabell; Hagemeier, Birte; Wefers, Benedikt; Müller, Stephan A.; Wurst, Wolfgang; Sanchez-Garcia, Elsa; Zimmermann, Alexander; Hu, Xiao-Yu; Clausen, Tim; Huber, Robert; Lichtenthaler, Stefan F.; Schmuck, Carsten; Giese, Michael; Kaiser, Markus; Ehrmann, Michael; Dichgans, Martin
    Rational correction of pathogenic conformational defects in HTRA1
    In: Nature Communications Vol. 15 (2024) Nr. 1, 5944
    Online Full Text: dx.doi.org/ (Open Access)
  • Huang, Jing; Jaekel, Andreas; van den Boom, Johannes; Podlesainski, David; Elnaggar, M.; Heuer-Jungemann, A.; Kaiser, Markus; Meyer, Hemmo; Saccà, Barbara
    A modular DNA origami nanocompartment for engineering a cell-free, protein unfolding and degradation pathway
    In: Nature Nanotechnology Vol. 19 (2024) Nr. 10, pp. 1521 - 1531
    Online Full Text: dx.doi.org/ (Open Access)
  • Pleuger, Richard; Cozma, Christian; Hohoff, Simone; Denkhaus, Christian; Dudziak, Alexander; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Vetter, Ingrid R.; Westermann, Stefan
    Microtubule end-on attachment maturation regulates Mps1 association with its kinetochore receptor
    In: Current Biology Vol. 34 (2024) Nr. 11, pp. 2279 - 2293.e6
    Online Full Text: dx.doi.org/ (Open Access)
  • Meyer, Hemmo; Kravic, Bojana
    The Endo-Lysosomal Damage Response
    In: Annual Review of Biochemistry Vol. 93 (2024) Nr. 1, pp. 367 - 387
    Online Full Text: dx.doi.org/ (Open Access)
  • Day, Matthew; Tetik, Bilal; Parlak, Milena; Almeida-Hernández, Yasser; Räschle, Markus; Kaschani, Farnusch; Siegert, Heike; Marko, Anika; Sanchez-Garcia, Elsa; Kaiser, Markus; Barker, Isabel A.; Pearl, Laurence H.; Oliver, Antony W.; Boos, Dominik
    TopBP1 utilises a bipartite GINS binding mode to support genome replication
    In: Nature Communications Vol. 15 (2024) Nr. 1, 1797
    Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access)
  • Polley, Soumitra; Raisch, Tobias; Ghetti, Sabrina; Körner, Marie; Terbeck, Melina; Gräter, Frauke; Raunser, Stefan; Aponte-Santamaría, Camilo; Vetter, Ingrid R.; Musacchio, Andrea
    Structure of the human KMN complex and implications for regulation of its assembly
    In: Nature Structural & Molecular Biology Vol. 31 (2024) Nr. 6, pp. 861 - 873
    Online Full Text: dx.doi.org/ (Open Access)
  • Mirsanaye, Ann Schirin; Hoffmann, Saskia; Weisser, Melanie; Mund, Andreas; Lopez Mendez, Blanca; Typas, Dimitris; van den Boom, Johannes; Benedict, Bente; Hendriks, Ivo A.; Nielsen, Michael Lund; Meyer, Hemmo; Duxin, Julien P.; Montoya, Guillermo; Mailand, Niels
    VCF1 is a p97/VCP cofactor promoting recognition of ubiquitylated p97-UFD1-NPL4 substrates
    In: Nature Communications Vol. 15 (2024) Nr. 1, 2459
    Online Full Text: dx.doi.org/ (Open Access)
  • Hedtfeld, Marius; Dammers, Alicia; Koerner, Carolin; Musacchio, Andrea
    A validation strategy to assess the role of phase separation as a determinant of macromolecular localization
    In: Molecular Cell Vol. 84 (2024) Nr. 9, pp. 1783 - 1801.e7
    Online Full Text: dx.doi.org/ (Open Access)
  • Gahlot, Pinki; Kravic, Bojana; Rota, Giulia; van den Boom, Johannes; Levantovsky, Sophie; Schulze, Nina; Maspero, Elena; Polo, Simona; Behrends, Christian; Meyer, Hemmo
    Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH
    In: Molecular Cell (2024) pp. 1556 - 1569.e10
    Online Full Text: dx.doi.org/ (Open Access)
  • Musacchio, Andrea
    Thirty years of structural changes
    In: Nature Structural & Molecular Biology Vol. 31 (2024) Nr. 1, pp. 4 - 5
    Online Full Text: dx.doi.org/

    • 2023

  • Nanda, Suchet; Calderon, Abram; Sachan, Arya; Duong, Thanh-Thuy; Koch, Johannes; Xin, Xiaoyi; Solouk-Stahlberg, Djamschid; Wu, Yao-Wen; Nalbant, Perihan; Dehmelt, Leif
    Rho GTPase activity crosstalk mediated by Arhgef11 and Arhgef12 coordinates cell protrusion-retraction cycles
    In: Nature Communications Vol. 14 (2023) Nr. 1, 8356
    Online Full Text: dx.doi.org/ (Open Access)
  • Rüttermann, Maximilian; Koci, Michelle; Lill, Pascal; Geladas, Ermis Dionysios; Kaschani, Farnusch; Klink, Björn Udo; Erdmann, Ralf; Gatsogiannis, Christos
    Structure of the peroxisomal Pex1/Pex6 ATPase complex bound to a substrate
    In: Nature Communications Vol. 14 (2023) Nr. 1, 5942
    Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access)
  • Cmentowski, Verena; Ciossani, Giuseppe; d'Amico, Ennio; Wohlgemuth, Sabine; Owa, Mikito; Dynlacht, Brian; Musacchio, Andrea
    RZZ‐Spindly and CENP‐E form an integrated platform to recruit dynein to the kinetochore corona
    In: The EMBO Journal Vol. 42 (2023) Nr. 24, e114838
    Online Full Text: dx.doi.org/
  • Harms, Mirja; Smith, Nikaïa; Han, Mingyu; Groß, Rüdiger; von Maltitz, Pascal; Stürzel, Christina; Ruiz-Blanco, Yasser B.; Almeida-Hernández, Yasser; Rodriguez-Alfonso, Armando; Cathelin, Dominique; Caspar, Birgit; Tahar, Bouceba; Sayettat, Sophie; Bekaddour, Nassima; Vanshylla, Kanika; Kleipass, Franziska; Wiese, Sebastian; Ständker, Ludger; Klein, Florian; Lagane, Bernard; Boonen, Arnaud; Schols, Dominique; Benichou, Serge; Sanchez-Garcia, Elsa; Herbeuval, Jean-Philippe; Münch, Jan
    Spermine and spermidine bind CXCR4 and inhibit CXCR4- but not CCR5-tropic HIV-1 infection
    In: Science Advances Vol. 9 (2023) Nr. 27, eadf8251
    Online Full Text: dx.doi.org/ (Open Access)
  • van den Boom, Johannes; Marini, Guendalina; Meyer, Hemmo; Saibil, Helen R
    Structural basis of ubiquitin-independent PP1 complex disassembly by p97
    In: The EMBO Journal Vol. 42 (2023) Nr. 14, e113110
    Online Full Text: dx.doi.org/ (Open Access)
  • Cao, Yunjun; Mieres-Perez, Joel; Rowen, Julien Frederic; Sanchez-Garcia, Elsa; Sander, Wolfram; Morgenstern, Karina
    Chirality control of a single carbene molecule by tip-induced van der Waals interactions
    In: Nature Communications Vol. 14 (2023) Nr. 1, 4500
    Online Full Text: dx.doi.org/ (Open Access)
  • Polley, Soumitra; Müschenborn, Helen; Terbeck, Melina; De Antoni, Anna; Vetter, Ingrid R; Dogterom, Marileen; Musacchio, Andrea; Volkov, Vladimir A; Huis in 't Veld, Pim J
    Stable kinetochore-microtubule attachment requires loop-dependent Ndc80-Ndc80 binding
    In: The EMBO Journal Vol. 42 (2023) Nr. 13, e112504
    Online Full Text: dx.doi.org/ (Open Access)
  • Hoi, David M.; Junker, Sabryna; Junk, Lukas; Schwechel, Kristin; Fischel, Katharina; Podlesainski, David; Hawkins, Paige M.E.; van Geelen, Lasse; Kaschani, Farnusch; Leodolter, Julia; Morreale, Francesca Ester; Kleine, Stefan; Guha, Somraj; Rumpel, Klaus; Schmiedel, Volker M.; Weinstabl, Harald; Meinhart, Anton; Payne, Richard J.; Kaiser, Markus; Hartl, Markus; Boehmelt, Guido; Kazmaier, Uli; Kalscheuer, Rainer; Clausen, Tim
    Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival
    In: Cell Vol. 186 (2023) Nr. 10, pp. 2176 - 2192.e22
    Online Full Text: dx.doi.org/ (Open Access)
  • Blüggel, Mike; Kröning, Alexander; Kracht, Matthias; van den Boom, Johannes; Dabisch, Matthias; Göhring, Anna; Kaschani, Farnusch; Kaiser, Markus; Bayer, Peter; Meyer, Hemmo; Beuck, Christine
    The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPase
    In: Nature Communications Vol. 14 (2023) Nr. 1, 3258
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Chen, Chu; Piano, Valentina; Alex, Amal; Han, Simon J Y; Huis In 't Veld, Pim J.; Roy, Babhrubahan; Fergle, Daniel; Musacchio, Andrea; Joglekar, Ajit P.; Huis in ’t Veld, Pim J.
    The structural flexibility of MAD1 facilitates the assembly of the Mitotic Checkpoint Complex
    In: Nature Communications Vol. 14 (2023) Nr. 1, 1529
    Online Full Text: dx.doi.org/ (Open Access)

    • 2022

  • Schmerling, Christian; Sewald, Leonard; Heilmann, Geronimo; Witfeld, Frederick; Begerow, Dominik; Jensen, Kenneth; Bräsen, Christopher; Kaschani, Farnusch; Overkleeft, Herman S.; Siebers, Bettina; Kaiser, Markus
    Erratum: Author Correction: Identification of fungal lignocellulose-degrading biocatalysts secreted by Phanerochaete chrysosporium via activity-based protein profiling (Communications biology (2022) 5 1 (1254))
    In: Communications Biology Vol. 5 (2022) Nr. 1, pp. 1319
    Online Full Text: dx.doi.org/ (Open Access)
  • Carvalho, Luís A. R.; Ross, Breyan; Fehr, Lorenz; Bolgi, Oguz; Wöhrle, Svenja; Lum, Kenneth M.; Podlesainski, David; Vieira, Andreia C.; Kiefersauer, Reiner; Félix, Rita; Rodrigues, Tiago; Lucas, Susana D.; Groß, Olaf; Geiss‐Friedlander, Ruth; Cravatt, Benjamin F.; Huber, Robert; Kaiser, Markus; Moreira, Rui
    Chemoproteomics‐Enabled Identification of 4‐Oxo‐β‐Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9
    In: Angewandte Chemie International Edition Vol. 61 (2022) Nr. 47, e202210498
    Online Full Text: dx.doi.org/ (Open Access)
  • Zonderland, Gijs; Vanzo, Riccardo; Amitash, Sampath; Martín-Doncel, Elena; Coscia, Fabian; Mund, Andreas; Lerdrup, Mads; Benada, Jan; Boos, Dominik; Toledo, Luis
    The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition
    In: Molecular Cell Vol. 82 (2022) Nr. 18, pp. 3350 - 3365.e7
    Online Full Text: dx.doi.org/ (Open Access)
  • Morreale, Francesca E.; Kleine, Stefan; Leodolter, Julia; Junker, Sabryna; Hoi, David M.; Ovchinnikov, Stepan; Okun, Anastasia; Kley, Juliane; Kurzbauer, Robert; Junk, Lukas; Guha, Somraj; Podlesainski, David; Kazmaier, Uli; Boehmelt, Guido; Weinstabl, Harald; Rumpel, Klaus; Schmiedel, Volker M.; Hartl, Markus; Haselbach, David; Meinhart, Anton; Kaiser, Markus; Clausen, Tim
    BacPROTACs mediate targeted protein degradation in bacteria
    In: Cell Vol. 185 (2022) Nr. 13, pp. 2338 - 2353.e18
    Online Full Text: dx.doi.org/ (Open Access)
  • Rey, Juliana; Breiden, Maike; Lux, Vanda; Bluemke, Anika; Steindel, Maike; Ripkens, Kamilla; Möllers, Bastian; Bravo Rodriguez, Kenny; Boisguerin, Prisca; Volkmer, Rudolf; Mieres-Perez, Joel; Clausen, Tim; Sánchez-García, Elsa; Ehrmann, Michael
    An allosteric HTRA1-calpain 2 complex with restricted activation profile
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 119 (2022) Nr. 14, e2113520119
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Bolgi, Oguz; Silva-Garcia, Maria; Ross, Breyan; Pilla, Esther; Kari, Vijayalakshmi; Killisch, Markus; Spitzner, Melanie; Stark, Nadine; Lenz, Christof; Weiss, Konstantin; Donzelli, Laura; Gorrell, Mark D.; Grade, Marian; Riemer, Jan; Urlaub, Henning; Dobbelstein, Matthias; Huber, Robert; Geiss-Friedlander, Ruth
    Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair
    In: EMBO Reports Vol. 23 (2022) Nr. 10, e54136
    Online Full Text: dx.doi.org/ (Open Access)
  • Schmerling, Christian; Sewald, Leonard; Heilmann, Geronimo; Witfeld, Frederick; Begerow, Dominik; Jensen, Kenneth; Bräsen, Christopher; Kaschani, Farnusch; Overkleeft, Herman S.; Siebers, Bettina; Kaiser, Markus
    Identification of fungal lignocellulose-degrading biocatalysts secreted by Phanerochaete chrysosporium via activity-based protein profiling
    In: Communications Biology Vol. 5 (2022) Nr. 1, 1254
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Pesenti, Marion E.; Raisch, Tobias; Conti, Duccio; Walstein, Kai; Hoffmann, Ingrid; Vogt, Dorothee; Prumbaum, Daniel; Vetter, Ingrid R.; Raunser, Stefan; Musacchio, Andrea
    Structure of the human inner kinetochore CCAN complex and its significance for human centromere organization
    In: Molecular Cell Vol. 82 (2022) Nr. 11, pp. 2113 - 2131.e8
    Online Full Text: dx.doi.org/ (Open Access)
  • Raisch, Tobias; Ciossani, Giuseppe; d’Amico, Ennio; Cmentowski, Verena; Carmignani, Sara; Maffini, Stefano; Merino, Felipe; Wohlgemuth, Sabine; Vetter, Ingrid R.; Raunser, Stefan; Musacchio, Andrea
    Structure of the RZZ complex and molecular basis of Spindly‐driven corona assembly at human kinetochores
    In: The EMBO Journal Vol. 41 (2022) Nr. 9, e110411
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Bera, Abhijit; Henkel, Stefan; Mieres-Perez, Joel; Andargie Tsegaw, Yetsedaw; Sanchez-Garcia, Elsa; Sander, Wolfram; Morgenstern, Karina
    Surface Diffusion Aided by a Chirality Change of Self-Assembled Oligomers under 2D Confinement
    In: Angewandte Chemie International Edition Vol. 61 (2022) Nr. 43, e202212245
    Online Full Text: dx.doi.org/ (Open Access)
  • Chauvistré, Heike; Shannan, Batool; Daignault-Mill, Sheena M.; Ju, Robert J.; Picard, Daniel; Egetemaier, Stefanie; Váraljai, Renáta; Gibhardt, Christine S.; Sechi, Antonio; Kaschani, Farnusch; Keminer, Oliver; Stehbens, Samantha J.; Liu, Qin; Yin, Xiangfan; Jeyakumar, Kirujan; Vogel, Felix C. E.; Krepler, Clemens; Rebecca, Vito W.; Kubat, Linda; Lueong, Smiths S.; Forster, Jan; Horn, Susanne; Remke, Marc; Ehrmann, Michael; Paschen, Annette; Becker, Jürgen; Helfrich, Iris; Rauh, Daniel; Kaiser, Markus; Gul, Sheraz; Herlyn, Meenhard; Bogeski, Ivan; Rodríguez-López, José Neptuno; Haass, Nikolas K.; Schadendorf, Dirk; Rösch, Alexander;
    Persister state-directed transitioning and vulnerability in melanoma
    32. Deutscher Hautkrebskongress (ADO-Jahrestagung), 14.–17. September 2022, Hannover, Germany,
    In: Nature Communications Vol. 13 (2022) Nr. 1, pp. 35 - 36
    Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Kosinski, Richard; Perez, Joel Mieres; Schöneweiß, Elisa-C.; Ruiz-Blanco, Yasser B.; Ponzo, Irene; Bravo-Rodriguez, Kenny; Erkelenz, Michael; Schlücker, Sebastian; Uhlenbrock, Guido; Sánchez-García, Elsa; Sacca, Barbara
    The role of DNA nanostructures in the catalytic properties of an allosterically regulated protease
    In: Science Advances Vol. 8 (2022) Nr. 1, abk0425
    Online Full Text: dx.doi.org/ (Open Access)
  • Kravić, Bojana; Bionda, Tihana; Siebert, Alexander; Gahlot, Pinki; Levantovsky, Sophie; Behrends, Christian; Meyer, Hemmo
    Ubiquitin profiling of lysophagy identifies actin stabilizer CNN2 as a target of VCP/p97 and uncovers a link to HSPB1
    In: Molecular Cell Vol. 82 (2022) Nr. 14, pp. 2633 - 2649.e7
    Online Full Text: dx.doi.org/ (Open Access)
  • Musacchio, Andrea
    On the role of phase separation in the biogenesis of membraneless compartments
    In: The EMBO Journal Vol. 41 (2022) Nr. 5, e109952
    Online Full Text: dx.doi.org/ (Open Access)

    • 2021

  • Böhm, Miriam; Killinger, Kerstin; Dudziak, Alexander; Pant, Pradeep; Jänen, Karolin; Hohoff, Simone; Mechtler, Karl; Örd, Mihkel; Loog, Mart; Sánchez-García, Elsa; Westermann, Stefan
    Cdc4 phospho-degrons allow differential regulation of ame1ceⁿp⁻u protein stability across the cell cycle
    In: eLife Vol. 10 (2021) e67390
    Online Full Text: dx.doi.org/ (Open Access)
  • König, Gerhard; Sokkar, Pandian; Pryk, Niclas; Heinrich, Sascha; Möller, David; Cimicata, Giuseppe; Matzov, Donna; Dietze, Pascal; Thiel, Walter; Bashan, Anat; Bandow, Julia Elisabeth; Zuegg, Johannes; Yonath, Ada; Schulz, Frank; Sánchez-García, Elsa
    Rational prioritization strategy allows the design of macrolide derivatives that overcome antibiotic resistance
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 118 (2021) Nr. 46, e2113632118
    Online Full Text: dx.doi.org/ (Open Access)
  • Sokkar, Pandian; Harms, Mirja; Stürzel, Christina; Gilg, Andrea; Kizilsavas, Gönül; Raasholm, Martina; Preising, Nico; Wagner, Manfred; Kirchhoff, Frank; Ständker, Ludger; Weidinger, Gilbert; Mayer, Benjamin; Münch, Jan; Sánchez-García, Elsa
    Computational modeling and experimental validation of the EPI-X4/CXCR4 complex allows rational design of small peptide antagonists
    In: Communications Biology Vol. 4 (2021) Nr. 1, 1113
    Online Full Text: dx.doi.org/ (Open Access)
  • Dorsch, Madeleine; Kowalczyk, Manuela; Planque, Mélanie; Heilmann, Geronimo; Urban, Sebastian; Dujardin, Philip; Forster, Jan; Ueffing, Kristina; Nothdurft, Silke; Oeck, Sebastian; Paul, Annika; Liffers, Sven T.; Kaschani, Farnusch; Kaiser, Markus; Schramm, Alexander; Siveke, Jens; Winslow, Monte M.; Fendt, Sarah-Maria; Nalbant, Perihan; Grüner, Barbara M.
    Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis
    In: Cell Reports Vol. 37 (2021) Nr. 8, 110056
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Dudziak, Alexander; Engelhard, Lena; Bourque, Cole; Klink, Björn Udo; Rombaut, Pascaline; Kornakov, Nikolay; Jänen, Karolin; Herzog, Franz; Gatsogiannis, Christos; Westermann, Stefan
    Phospho-regulated Bim1/EB1 interactions trigger Dam1c ring assembly at the budding yeast outer kinetochore
    In: The EMBO Journal Vol. 40 (2021) Nr. 18, e108004
    Online Full Text: dx.doi.org/ (Open Access)
  • van den Boom, Johannes; Kück, Anja; Kravic, Bojana; Müschenborn, Helen; Giesing, Maike; Pan, Dongqing; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Meyer, Hemmo
    Targeted substrate loop insertion by VCP/p97 during PP1 complex disassembly
    In: Nature Structural & Molecular Biology Vol. 28 (2021) Nr. 12, pp. 964 - 971
    Online Full Text: dx.doi.org/
  • Walstein, Kai; Petrovic, Arsen; Pan, Dongqing; Hagemeier, Birte; Vogt, Dorothee; Vetter, Ingrid R.; Musacchio, Andrea
    Assembly principles and stoichiometry of a complete human kinetochore module
    In: Science Advances Vol. 7 (2021) Nr. 27, eabg1037
    Online Full Text: dx.doi.org/ (Open Access)
  • Wettstein, Lukas; Weil, Tatjana; Conzelmann, Carina; Müller, Janis A.; Groß, Rüdiger; Hirschenberger, Maximilian; Seidel, Alina; Klute, Susanne; Zech, Fabian; Prelli Bozzo, Caterina; Preising, Nico; Fois, Giorgio; Lochbaum, Robin; Knaff, Philip Maximilian; Mailänder, Volker; Ständker, Ludger; Thal, Dietmar Rudolf; Schumann, Christian; Stenger, Steffen; Kleger, Alexander; Lochnit, Günter; Mayer, Benjamin; Ruiz-Blanco, Yasser B.; Hoffmann, Markus; Sparrer, Konstantin M. J.; Pöhlmann, Stefan; Sánchez-García, Elsa; Kirchhoff, Frank; Frick, Manfred; Münch, Jan
    Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection
    In: Nature Communications Vol. 12 (2021) Nr. 1, pp. 1726
    Online Full Text: dx.doi.org/ (Open Access)
  • Cao, Yingying; Kitanovski, Simo; Küppers, Ralf; Hoffmann, Daniel
    UMI or not UMI, that is the question for scRNA-seq zero-inflation
    In: Nature Biotechnology Vol. 39 (2021) Nr. 2, pp. 158 - 159
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Singh, Priyanka; Pesenti, Marion E.; Maffini, Stefano; Carmignani, Sara; Hedtfeld, Marius; Petrovic, Arsen; Srinivasamani, Anupallavi; Bange, Tanja; Musacchio, Andrea
    BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in Mitosis
    In: Molecular Cell Vol. 81 (2021) Nr. 1, pp. 67 - 87.e9
    Online Full Text: dx.doi.org/ (Open Access)
  • Lee, Jung-Hoon; Bollschweiler, Daniel; Schäfer, Tillman; Huber, Robert
    Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assemblies
    In: Science Advances Vol. 7 (2021) Nr. 2, pp. eabd4413
    Online Full Text: dx.doi.org/ (Open Access)
  • Piano, Valentina; Alex, Amal; Stege, Patricia; Maffini, Stefano; Stoppiello, Gerardo A.; Huis In'T Veld, Pim J.; Vetter, Ingrid R.; Musacchio, Andrea
    CDC20 assists its catalytic incorporation in the mitotic checkpoint complex
    In: Science Vol. 371 (2021) Nr. 6524, pp. 67 - 71
    Online Full Text: dx.doi.org/
  • Meiners, Annika; Bäcker, Sandra; Hadrovic, Inesa; Heid, Christian; Beuck, Christine; Ruiz-Blanco, Yasser B.; Mieres-Perez, Joel; Pörschke, Marius; Grad, Jean-Noël; Vallet, Cecilia; Hoffmann, Daniel; Bayer, Peter; Sánchez-García, Elsa; Schrader, Thomas; Knauer, Shirley
    Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezers
    In: Nature Communications Vol. 12 (2021) Nr. 1, pp. 1505
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Mueller, Franziska; Friese, Alexandra; Pathe, Claudio; da Silva, Richard Cardoso; Bravo Rodriguez, Kenny; Musacchio, Andrea; Bange, Tanja
    Overlap of NatA and IAP substrates implicates N-terminal acetylation in protein stabilization
    In: Science Advances Vol. 7 (2021) Nr. 3, pp. eabc8590
    Online Full Text: dx.doi.org/ (Open Access)

    • 2020

  • Klatt, Felix; Leitner, Alexander; Kim, Iana V.; Ho-Xuan, Hung; Schneider, Elisabeth V.; Langhammer, Franziska; Weinmann, Robin; Müller, Melanie R.; Huber, Robert; Meister, Gunter; Kuhn, Claus-D.
    A precisely positioned MED12 activation helix stimulates CDK8 kinase activity
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 117 (2020) Nr. 6, pp. 2894 - 2905
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Gigante, Alba; Sijbesma, Eline; Sánchez-Murcia, Pedro A.; Hu, Xiaoyu; Bier, David; Bäcker, Sandra; Knauer, Shirley; Gago, Federico; Ottmann, Christian; Schmuck, Carsten
    A Supramolecular Stabilizer of the 14-3-3ζ/ERα Protein-Protein Interaction with a Synergistic Mode of Action
    In: Angewandte Chemie International Edition Vol. 132 (2020) Nr. 13, pp. 5322 - 5325
    Online Full Text: dx.doi.org/ (Open Access)
  • Merdanovic, Melisa; Burston, Steven G.; Schmitz, Anna Laura; Köcher, Steffen; Knapp, Stefan; Clausen, Tim; Kaiser, Markus; Huber, Robert; Ehrmann, Michael
    Activation by substoichiometric inhibition
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 117 (2020) Nr. 3, pp. 1414 - 1418
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Vallet, Cecilia; Aschmann, Dennis; Beuck, Christine; Killa, Matthias; Meiners, Annika; Mertel, Marcel; Ehlers, Martin; Bayer, Peter; Schmuck, Carsten; Giese, Michael R. A.; Knauer, Shirley
    Functional Disruption of the Cancer-Relevant Interaction between Survivin and Histone H3 with a Guanidiniocarbonyl Pyrrole Ligand
    In: Angewandte Chemie International Edition Vol. 59 (2020) Nr. 14, pp. 5567 - 5571
    Online Full Text: dx.doi.org/ (Open Access)
  • Kamps, Dominic; Koch, Johannes; Juma, Victor O.; Campillo-Funollet, Eduard; Gräßl, Melanie; Banerjee, Soumya; Mazel, Tomáš; Chen, Xi; Wu, Yao-Wen; Portet, Stephanie; Madzvamuse, Anotida; Nalbant, Perihan; Dehmelt, Leif
    Optogenetic Tuning Reveals Rho Amplification-Dependent Dynamics of a Cell Contraction Signal Network
    In: Cell Reports Vol. 33 (2020) Nr. 9, pp. 108467
    Online Full Text: dx.doi.org/ (Open Access)
  • Schütz, Desiree; Ruiz-Blanco, Yasser B.; Münch, Jan; Kirchhoff, Frank; Sánchez-García, Elsa; Müller, Janis A.
    Peptide and peptide-based inhibitors of SARS-CoV-2 entry
    In: Advanced Drug Delivery Reviews Vol. 167 (2020) pp. 47 - 65
    Online Full Text: dx.doi.org/ (Open Access)
  • Sijbesma, Eline; Visser, Emira; Plitzko, Kathrin; Thiel, Philipp; Milroy, Lech-Gustav; Kaiser, Markus; Brunsveld, Luc; Ottmann, Christian
    Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactions
    In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 3954
    Online Full Text: dx.doi.org/ (Open Access)
  • Spassova, Ivelina; Ugurel, Selma; Terheyden, Patrick; Sucker, Antje; Hassel, Jessica C.; Ritter, Cathrin; Kubat, Linda; Habermann, Daniel; Farahpour, Farnoush; Saeedghalati, Mohammadkarim; Peiffer, Lukas; Kumar, Rajiv; Schrama, David; Hoffmann, Daniel; Schadendorf, Dirk; Becker, Jürgen C.
    Predominance of Central Memory T Cells with High T-Cell Receptor Repertoire Diversity is Associated with Response to PD-1/PD-L1 Inhibition in Merkel Cell Carcinoma
    In: Clinical Cancer Research Vol. 26 (2020) Nr. 9, pp. 2257 - 2267
    Online Full Text: dx.doi.org/ (Open Access)
  • Killinger, Kerstin; Böhm, Miriam; Steinbach, Philine; Hagemann, Götz; Blüggel, Mike; Jänen, Karolin; Hohoff, Simone; Bayer, Peter; Herzog, Franz; Westermann, Stefan
    Auto-inhibition of Mif2/CENP-C ensures centromere-dependent kinetochore assembly in budding yeast
    In: The EMBO Journal Vol. 39 (2020) Nr. 14, pp. e102938
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)

    • 2019

  • Alex, Amal; Piano, Valentina; Polley, Soumitra; Stuiver, Marchel; Voss, Stephanie; Ciossani, Giuseppe; Overlack, Katharina; Voss, Beate; Wohlgemuth, Sabine; Petrovic, Arsen; Wu, Yaowen; Selenko, Philipp; Musacchio, Andrea; Maffini, Stefano
    Electroporated recombinant proteins as tools for in vivo functional complementation, imaging and chemical biology
    In: eLife Vol. 8 (2019) pp. e48287
    Online Full Text: dx.doi.org/ (Open Access)
  • Hellerschmied, Doris; Lehner, Anita; Franicevic, Nina; Arnese, Renato; Johnson, Chloe; Vogel, Antonia; Meinhart, Anton; Kurzbauer, Robert; Deszcz, Luiza; Gazda, Linn; Geeves, Michael; Clausen, Tim
    Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin
    In: Nature Communications Vol. 10 (2019) Nr. 1, 4781
    Online Full Text: dx.doi.org/ (Open Access)
  • Alavian, Seyed Moayed; Price, David A.; Panning, Marcus; Neumann-Haefelin, Christoph; Bockmann, Jan; Wiesch, Julian Schulze zur; Wedemeyer, Heiner; Heinold, Andreas; Alizei, Elahe Salimi; Timm, Jörg; Casillas, Rosario; Protzer, Ulrike; Raziorrouh, Bijan; Smedile, Antonina; Rodríguez-Frías, Francisco; Hoffmann, Daniel; Oberhardt, Valerie; Buti, Maria; Thimme, Robert; Roggendorf, Michael; Hofmann, Maike; Gostick, Emma; Budeus, Bettina; Emmerich, Florian; Kiraithe, Muthamia M.; Karimzadeh, Hadi
    Viral escape contributes to the failure of hepatitis D virus-specific CD8+ T-cells and drives evolution of HDV
    In: Journal of Hepatology Vol. 70 (2019) Nr. Suppl. 1, pp. e21
    Online Full Text: dx.doi.org/
  • Karimzadeh, Hadi; Kiraithe, Muthamia M.; Oberhardt, Valerie; Salimi Alizei, Elahe; Bockmann, Jan; Schulze zur Wiesch, Julian; Budeus, Bettina; Hoffmann, Daniel; Wedemeyer, Heiner; Cornberg, Markus; Krawczyk, Adalbert; Rashidi-Alavijeh, Jassin; Rodríguez-Frías, Francisco; Casillas, Rosario; Buti, Maria; Smedile, Antonina; Alavian, Seyed Moayed; Heinold, Andreas; Emmerich, Florian; Panning, Marcus; Gostick, Emma; Price, David A.; Timm, Jörg; Hofmann, Maike; Raziorrouh, Bijan; Thimme, Robert; Protzer, Ulrike; Roggendorf, Michael; Neumann-Haefelin, Christoph
    Mutations in Hepatitis D Virus Allow It to Escape Detection by CD8⁺ T Cells and Evolve at the Population Level
    In: Gastroenterology Vol. 156 (2019) Nr. 6, pp. 1820 - 1833
    Online Full Text: dx.doi.org/ (Open Access)
  • Wülling, Manuela; Vortkamp, Andrea
    A newly discovered stem cell that keeps bones growing
    In: Nature Vol. 567 (2019) Nr. 7747, pp. 178 - 179
    Online Full Text: dx.doi.org/ (Open Access)
  • Körver, Lisa; Papadopoulos, Chrisovalantis; Liu, Bin; Kravic, Bojana; Rota, Giulia; Brecht, Lukas; Veenendaal, Tineke; Polajnar, Mira; Blümke, Anika; Ehrmann, Michael; Klumperman, Judith; Jäättelä, Marja; Behrends, Christian; Meyer, Hemmo
    The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal damage
    In: EMBO Reports (2019) pp. e48014
    Online Full Text: dx.doi.org/ (Open Access)
  • Siemer, Svenja; Westmeier, Dana; Barz, Matthias; Eckrich, Jonas; Wünsch, Désirée; Seckert, Christof; Thyssen, Christian; Schilling, Oliver; Hasenberg, Mike; Pang, Chengfan; Docter, Dominic; Knauer, Shirley K.; Stauber, Roland H.; Strieth, Sebastian
    Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing : Implications for the design of improved nanoantibiotics
    In: Biomaterials Vol. 192 (2019) pp. 551 - 559
    Online Full Text: dx.doi.org/
  • Smith, Nikaïa; Rodero, Mathieu P.; Bekaddour, Nassima; Bondet, Vincent; Ruiz-Blanco, Yasser B.; Harms, Mirja; Mayer, Benjamin; Badder-Meunier, Brigitte; Quartier, Pierre; Bodemer, Christine; Baudouin, Véronique; Dieudonné, Yannick; Kirchhoff, Frank; Sánchez-García, Elsa; Charbit, Bruno; Leboulanger, Nicolas; Jahrsdörfer, Bernd; Richard, Yolande; Korganow, Anne-Sophie; Münch, Jan; Nisole, Sébastien; Duffy, Darragh; Herbeuval, Jean-Philippe
    Control of TLR7-mediated type i IFN signaling in pDCs through CXCR4 engagement - A new target for lupus treatment
    In: Science Advances Vol. 5 (2019) Nr. 7, pp. eaav9019
    Online Full Text: dx.doi.org/ (Open Access)
  • Pan, Dongqing; Walstein, Kai; Take, Annika; Bier, David; Kaiser, Nadine; Musacchio, Andrea
    Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing
    In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 4046
    Online Full Text: dx.doi.org/ (Open Access)
  • Huis In 't Veld, Pim J.; Volkov, Vladimir A.; Stender, Isabelle D.; Musacchio, Andrea; Dogterom, Marileen
    Molecular determinants of the Ska-Ndc80 interaction and their influence on microtubule tracking and force-coupling
    In: eLife Vol. 8 (2019) pp. e49539
    Online Full Text: dx.doi.org/ (Open Access)
  • Kosinski, Richard; Mukhortava, Ann; Pfeifer, Wolfgang; Candelli, Andrea; Rauch, Philipp; Sacca, Barbara
    Sites of high local frustration in DNA origami
    In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 1061
    Online Full Text: dx.doi.org/ (Open Access)
  • Buscaill, Pierre; Chandrasekar, Balakumaran; Sanguankiattichai, Nattapong; Kourelis, Jiorgos; Kaschani, Farnusch; Thomas, Emma L.; Morimoto, Kyoko; Kaiser, Markus; Preston, Gail M.; Ichinose, Yuki; Van Der Hoorn, Renier A.L.
    Glycosidase and glycan polymorphism control hydrolytic release of immunogenic flagellin peptides
    In: Science Vol. 364 (2019) Nr. 6436, eaav0748
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)

    • 2018

  • Day, Matthew; Rappas, Mathieu; Ptasinska, Katie; Boos, Dominik; Oliver, Antony W.; Pearl, Laurence H.
    BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands
    In: eLife Vol. 7 (2018) pp. e39979
    Online Full Text: dx.doi.org/ (Open Access)
  • Trusch, Franziska; Loebach, Lars; Wawra, Stephan; Durward, Elaine; Wuensch, Andreas; Iberahim, Nurul Aqilah; De Bruijn, Irene; MacKenzie, Kevin; Willems, Ariane; Toloczko, Aleksandra; Diéguez-Uribeondo, Javier; Rasmussen, Tim; Schrader, Thomas; Bayer, Peter; Secombes, Chris J.; Van West, Pieter
    Cell entry of a host-targeting protein of oomycetes requires gp96
    In: Nature Communications Vol. 9 (2018) Nr. 1, pp. 2347
    Online Full Text: dx.doi.org/ (Open Access)
  • Ross, Breyan; Krapp, Stephan; Augustin, Martin; Kierfersauer, Reiner; Arciniega, Marcelino; Geiss-Friedlander, Ruth; Huber, Robert
    Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 115 (2018) Nr. 7, pp. E1437 - E1445
    Online Full Text: dx.doi.org/ (Open Access)
  • Tucci, Felicia A.; Kitanovski, Simo; Johansson, Patricia; Klein-Hitpaß, Ludger; Kahraman, Alisan; Dürig, Jan; Hoffmann, Daniel; Küppers, Ralf
    Biased IGH VDJ gene repertoire and clonal expansions in B cells of chronically hepatitis C virus–infected individuals
    In: Blood Vol. 131 (2018) Nr. 5, pp. 546 - 557
    Online Full Text: dx.doi.org/ (Open Access)
  • Shen, Bin; Tatchen, Jörg; Sánchez-García, Elsa; Bettinger, Holger F.
    Evolution of the Optical Gap in the Acene Series : Undecacene
    In: Angewandte Chemie International Edition Vol. 57 (2018) Nr. 33, pp. 10506 - 10509
    Online Full Text: dx.doi.org/
  • Garcia-Guerrero, Maria C.; Garcia-Pardo, Javier; Berenguer, Esther; Fernandez-Alvarez, Roberto; Barfi, Gifty B.; Lyons, Peter J.; Aviles, Francesc X.; Huber, Robert; Lorenzo, Julia; Reverter, David
    Crystal structure and mechanism of human carboxypeptidase O : Insights into its specific activity for acidic residues
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 115 (2018) Nr. 17, pp. E3932 - E3939
    Online Full Text: dx.doi.org/ (Open Access)
  • Pesenti, Marion E; Prumbaum, Daniel; Auckland, Philip; Smith, Charlotte M; Faesen, Alex C; Petrovic, Arsen; Erent, Muriel; Maffini, Stefano; Pentakota, Satyakrishna; Weir, John R; Lin, Yu-Chih; Raunser, Stefan; McAinsh, Andrew D; Musacchio, Andrea
    Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80.
    In: Molecular Cell Vol. 71 (2018) Nr. 6, pp. 923 - 939.e10
    Online Full Text: dx.doi.org/ (Open Access)
  • Stauber, Roland H.; Siemer, Svenja; Becker, Sven; Ding, Guo-Bin; Strieth, Sebastian; Knauer, Shirley
    Small Meets Smaller : Effects of Nanomaterials on Microbial Biology, Pathology, and Ecology
    In: ACS Nano Vol. 12 (2018) Nr. 7, pp. 6351 - 6359
    Online Full Text: dx.doi.org/
  • Pöhler, Robert; Krahn, Jan; van den Boom, Johannes; Dobrynin, Grzegorz; Kaschani, Farnusch; Eggenweiler, Hans-Michael; Zenke, Frank T.; Kaiser, Markus; Meyer, Hemmo
    A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases
    In: Angewandte Chemie International Edition Vol. 57 (2018) Nr. 6, pp. 1576 - 1580
    Online Full Text: dx.doi.org/
  • Farahpour, Farnoush; Saeedghalati, Mohammadkarim; Brauer, Verena S.; Hoffmann, Daniel
    Trade-off shapes diversity in eco-evolutionary dynamics
    In: eLife Vol. 7 (2018) pp. e36273
    Online Full Text: dx.doi.org/ (Open Access)
  • Hellerschmied, Doris; Roessler, Max; Lehner, Anita; Gazda, Linn; Stejskal, Karel; Imre, Richard; Mechtler, Karl; Dammermann, Alexander; Clausen, Tim
    UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins
    In: Nature Communications Vol. 9 (2018) Nr. 1, 484
    Online Full Text: dx.doi.org/ (Open Access)
  • Weith, Matthias; Seiler, Jonas; van den Boom, Johannes; Kracht, Matthias; Hülsmann, Julia; Primorac, Ivana; Del Pino Garcia, Javier; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Bollen, Mathieu; Meyer, Hemmo
    Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation
    In: Molecular Cell Vol. 72 (2018) Nr. 4, pp. 766 - 777
    Online Full Text: dx.doi.org/ (Open Access)
  • Pfeifer, Wolfgang; Lill, Pascal; Gatsogiannis, Christos; Sacca, Barbara
    Hierarchical Assembly of DNA Filaments with Designer Elastic Properties
    In: ACS Nano Vol. 12 (2018) Nr. 1, pp. 44 - 55
    Online Full Text: dx.doi.org/
  • Westmeier, Dana; Hahlbrock, Angelina; Reinhardt, Christoph; Fröhlich-Nowoisky, Janine; Wessler, Silja; Vallet, Cecilia; Pöschl, Ulrich; Knauer, Shirley; Stauber, Roland H.
    Nanomaterial-microbe cross-talk : physicochemical principles and (patho)biological consequences
    In: Chemical Society Reviews Vol. 47 (2018) Nr. 14, pp. 5312 - 5337
    Online Full Text: dx.doi.org/
  • Westmeier, Dana; Solouk-Saran, Djamschid; Vallet, Cecilia; Siemer, Svenja; Docter, Dominic; Götz, Hermann; Männ, Linda; Hasenberg, Anja; Hahlbrock, Angelina; Erler, Kathrin; Reinhardt, Christoph; Schilling, Oliver; Becker, Sven; Gunzer, Matthias; Hasenberg, Mike; Knauer, Shirley; Stauber, Roland H.
    Nanoparticle decoration impacts airborne fungal pathobiology
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 115 (2018) Nr. 27, pp. 7087 - 7092
    Online Full Text: dx.doi.org/ (Open Access)
  • Schürmann, Sabine; Steffes, Georg; Manikowski, Dominique; Kastl, Philipp; Malkus, Ursula; Bandari, Shyam; Ohlig, Stefanie; Ortmann, Corinna; Rebollido-Rios, Rocio; Otto, Mandy; Nüsse, Harald; Hoffmann, Daniel; Klämbt, Christian; Galic, Milos; Klingauf, Jürgen; Grobe, Kay
    Proteolytic processing of palmitoylated Hedgehog peptides specifies the 3-4 intervein region of the Drosophila wing
    In: eLife Vol. 7 (2018) pp. e33033
    Online Full Text: dx.doi.org/ (Open Access)
  • van den Boom, Johannes; Meyer, Hemmo
    VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling
    In: Molecular Cell Vol. 69 (2018) Nr. 2, pp. 182 - 194
    Online Full Text: dx.doi.org/ (Open Access)

    • 2017

  • Papadopoulos, Chrisovalantis; Meyer, Hemmo
    Detection and Clearance of Damaged Lysosomes by the Endo-Lysosomal Damage Response and Lysophagy
    In: Current Biology Vol. 27 (2017) Nr. 24, pp. R1330 - R1341
    Online Full Text: dx.doi.org/
  • Zweerink, Susanne; Kallnik, Verena; Ninck, Sabrina; Nickel, Sabrina; Verheyen, Julia; Blum, Marcel; Wagner, Alexander; Feldmann, Ingo; Sickmann, Albert; Albers, Sonja-Verena; Bräsen, Christopher; Kaschani, Farnusch; Siebers, Bettina; Kaiser, Markus
    Activity-based protein profiling as a robust method for enzyme identification and screening in extremophilic Archaea
    In: Nature Communications Vol. 8 (2017) pp. 15352
    Online Full Text: dx.doi.org/ (Open Access)
  • Faesen, Alex C.; Thanasoula, Maria; Maffini, Stefano; Breit, Claudia; Müller, Franziska; Van Gerwen, Suzan; Bange, Tanja; Musacchio, Andrea
    Basis of catalytic assembly of the mitotic checkpoint complex
    In: Nature Vol. 542 (2017) Nr. 7642, pp. 498 - 502
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Pentakota, Satyakrishna; Zhou, Keda; Smith, Charlotte; Maffini, Stefano; Petrovic, Arsen; Morgan, Garry P.; Weir, John R.; Vetter, Ingrid R.; Musacchio, Andrea; Luger, Karolin
    Decoding the centromeric nucleosome through CENP-N
    In: eLife Vol. 6 (2017) pp. e33442
    Online Full Text: dx.doi.org/ (Open Access)
  • Overlack, Katharina; Bange, Tanja; Weissmann, Florian; Faesen, Alex C.; Maffini, Stefano; Primorac, Ivana; Müller, Franziska; Peters, Jan-Michael; Musacchio, Andrea
    BubR1 Promotes Bub3-Dependent APC/C Inhibition during Spindle Assembly Checkpoint Signaling
    In: Current Biology Vol. 27 (2017) Nr. 19, pp. 2915 - 2927.e7
    Online Full Text: dx.doi.org/ (Open Access)
  • Jiang, Hao; Hu, Xiao-Yu; Schlesiger, Stefanie; Li, Mao; Zellermann, Elio; Knauer, Shirley; Schmuck, Carsten
    Morphology-Dependent Cell Imaging by Using a Self-Assembled Diacetylene Peptide Amphiphile
    In: Angewandte Chemie International Edition Vol. 56 (2017) Nr. 46, pp. 14526 - 14530
    Online Full Text: dx.doi.org/
  • Vader, Gerben; Musacchio, Andrea
    The greatest kinetochore show on earth
    In: EMBO Reports Vol. 18 (2017) Nr. 9, pp. 1473 - 1475
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Papadopoulos, Chrisovalantis; Kirchner, Philipp; Bug, Monika; Grum, Daniel; Körver, Lisa; Schulze, Nina; Pöhler, Robert; Dressler, Alina; Fengler, Sven; Arhzaouy, Khalid; Lux, Vanda; Ehrmann, Michael; Weihl, Conrad C.; Meyer, Hemmo
    VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy
    In: The EMBO Journal Vol. 36 (2017) Nr. 2, pp. 135 - 150
    Online Full Text: dx.doi.org/ (Open Access)
  • Pan, Dongqing; Klare, Kerstin; Petrovic, Arsen; Take, Annika; Walstein, Kai; Singh, Priyanka; Rondelet, Arnaud; Bird, Alexander W; Musacchio, Andrea
    CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading
    In: eLife Vol. 6 (2017) pp. e23352
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Köcher, Steffen; Rey, Juliana; Bongard, Jens; Tiaden, André N.; Meltzer, Michael; Richards, Peter J.; Ehrmann, Michael; Kaiser, Markus
    Tailored Ahp-cyclodepsipeptides as Potent Non-covalent Serine Protease Inhibitors
    In: Angewandte Chemie International Edition Vol. 56 (2017) Nr. 29, Special Issue: 100th Anniversary of the Royal Australian Chemical Institute, pp. 8555 - 8558
    Online Full Text: dx.doi.org/
  • Jana, Poulami; Samanta, Krishnananda; Bäcker, Sandra; Zellermann, Elio; Knauer, Shirley; Schmuck, Carsten
    Efficient Gene Transfection through Inhibition of β-Sheet (Amyloid Fiber) Formation of a Short Amphiphilic Peptide by Gold Nanoparticles
    In: Angewandte Chemie International Edition Vol. 56 (2017) Nr. 28, pp. 8083 - 8088
    Online Full Text: dx.doi.org/
  • Schmitzberger, Florian; Richter, Magdalena M; Gordiyenko, Yuliya; Robinson, Carol V; Dadlez, Michał; Westermann, Stefan
    Molecular basis for inner kinetochore configuration through RWD domain–peptide interactions
    In: The EMBO Journal Vol. 36 (2017) Nr. 23, pp. 3458 - 3482
    Online Full Text: dx.doi.org/ (Open Access)
  • Sprengel, Andreas; Lill, Pascal; Stegemann, Pierre; Bravo-Rodriguez, Kenny; Schöneweiß, Elisa-Charlott; Merdanovic, Melisa; Gudnason, Daniel; Aznauryan, Mikayel; Gamrad, Lisa; Barcikowski, Stephan; Sánchez-García, Elsa; Birkedal, Victoria; Gatsogiannis, Christos; Ehrmann, Michael; Sacca, Barbara
    Tailored protein encapsulation into a DNA host using geometrically organized supramolecular interactions
    In: Nature Communications Vol. 8 (2017) pp. 14472
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Bantele, Susanne; Pfander, Dominik; Boos, Dominik; Ferreira, Pedro; Gritenaite, Dalia
    Targeting of the Fun30 nucleosome remodeller by the Dpb11 scaffold facilitates cell cycle-regulated DNA end resection
    In: eLife (2017) Nr. 6, pp. e21687
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)

    • 2016

  • Pekgöz Altunkaya, Gülsah; Malvezzi, Francesca; Demianova, Zuzana; Zimniak, Tomasz; Litos, Gabriele; Weissmann, Florian; Mechtler, Karl; Herzog, Franz; Westermann, Stefan
    CCAN Assembly Configures Composite Binding Interfaces to Promote Cross-Linking of Ndc80 Complexes at the Kinetochore
    In: Current Biology Vol. 26 (2016) Nr. 17, pp. 2370 - 2378
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Streich, Carmen; Akkari, Laura; Decker, Christina; Bormann, Jenny; Rehbock, Christoph; Müller-Schiffmann, Andreas; Niemeyer, Felix; Nagel-Steger, Luitgard; Willbold, Dieter; Sacca, Barbara; Kor, Carsten
    Characterizing the Effect of Multivalent Conjugates Composed of Aβ-Specific Ligands and Metal Nanoparticles on Neurotoxic Fibrillar Aggregation
    In: ACS Nano (2016) pp. 7582 - 7597
    Online Full Text: dx.doi.org/
  • Knorr, Johannes; Sokkar, Pandian; Schott, Sebastian; Costa, Paolo; Thiel, Walter; Sander, Wolfram; Sánchez-García, Elsa; Nuernberger, Patrick
    Competitive solvent-molecule interactions govern primary processes of diphenylcarbene in solvent mixtures
    In: Nature Communications Vol. 7 (2016) pp. 12968
    Online Full Text: dx.doi.org/ (Open Access)
  • Weissmann, Florian; Peters, Jan-Michael; Schulman, Brenda A.; Westermann, Stefan; Lampert, Fabienne; Stark, Holger; Huis in 't Veld, Pim J.; VanderLinden, Ryan; Petzold, Georg
    BiGBac enables rapid gene assembly for the expression of large multisubunit protein complexes
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 113 (2016) Nr. 19, pp. E2564 - E2569
    Online Full Text: dx.doi.org/ (Open Access)
  • Huisin’T Veld, Pim J.; Jeganathan, Sadasivam; Petrovic, Arsen; Singh, Priyanka; John, Juliane; Krenn, Veronica; Weissmann, Florian; Bange, Tanja; Musacchio, Andrea
    Molecular basis of outer kinetochore assembly on CENP-T
    In: eLife Vol. 5 (2016) pp. e21007
    Online Full Text: dx.doi.org/ (Open Access)
  • Weir, John R.; Faesen, Alex C.; Klare, Kerstin; Petrovic, Arsen; Basilico, Federica; Fischböck, Josef; Pentakota, Satyakrishna; Keller, Jenny; Pesenti, Marion E.; Pan, Dongqing; Vogt, Doro; Wohlgemuth, Sabine; Herzog, Franz; Musacchio, Andrea
    Insights from biochemical reconstitution into the architecture of human kinetochores
    In: Nature Vol. 537 (2016) Nr. 7619, pp. 249 - 253
    Online Full Text: dx.doi.org/
  • Lai, Ashton C.; Toure, Momar; Hellerschmied, Doris; Salami, Jemilat; Jaime-Figueroa, Saul; Ko, Eunhwa; Hines, John; Crews, Craig M.
    Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL
    In: Angewandte Chemie International Edition Vol. 55 (2016) Nr. 2, pp. 807 - 810
    Online Full Text: dx.doi.org/
  • Borisy, Gary; Musacchio, Andrea; Janke, Carsten; Howard, Jonathon; Heald, Rebecca; Nogales, Eva
    Microtubules : 50 years on from the discovery of tubulin
    In: Nature Reviews Molecular Cell Biology Vol. 17 (2016) Nr. 5, pp. 322 - 328
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Friese, Alexandra; Musacchio, Andrea; Herzog, Franz; Raunser, Stefan; Petrovic, Arsen; Prumbaum, Daniel; Fischböck, Josef; Huis in ‘t Veld,, Pim J.; Faesen, Alex C.
    Molecular requirements for the inter-subunit interaction and kinetochore recruitment of SKAP and Astrin
    In: Nature Communications Vol. 7 (2016) pp. 11407
    Online Full Text: dx.doi.org/ (Open Access)
  • Li, Mao; Ehlers, Martin; Schlesiger, Stefanie; Zellermann, Elio; Knauer, Shirley; Schmuck, Carsten
    Incorporation of a Non-Natural Arginine Analogue into a Cyclic Peptide Leads to Formation of Positively Charged Nanofibers Capable of Gene Transfection
    In: Angewandte Chemie International Edition Vol. 55 (2016) Nr. 2, pp. 598 - 601
    Online Full Text: dx.doi.org/
  • Arumughan, Anup; Roske, Yvette; Barth, Carolin; Forero, Laura Lleras; Bravo-Rodriguez, Kenny; Redel, Alexandra; Kostova, Simona; McShane, Erik; Opitz, Robert; Faelber, Katja; Rau, Kirstin; Mielke, Thorsten; Daumke, Oliver; Selbach, Matthias; Sánchez-García, Elsa; Rocks, Oliver; Panáková, Daniela; Heinemann, Udo; Wanker, Erich E.
    Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers
    In: Nature Communications Vol. 7 (2016) pp. 13047
    Online Full Text: dx.doi.org/ (Open Access)
  • Petrovic, Arsen; Keller, Jenny; Liu, Yahui; Overlack, Katharina; John, Juliane; Dimitrova, Yoana N.; Jenni, Simon; van Gerwen, Suzan; Stege, Patricia; Wohlgemuth, Sabine; Rombaut, Pascaline; Herzog, Franz; Harrison, Stephen C.; Vetter, Ingrid R.; Musacchio, Andrea
    Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores
    In: Cell Vol. 167 (2016) Nr. 4, pp. 1028 - 1040.e15
    Online Full Text: dx.doi.org/ (Open Access)
  • Molodtsov, Maxim I.; Mieck, Christine; Dobbelaere, Jeroen; Dammermann, Alexander; Westermann, Stefan; Vaziri, Alipasha
    A Force-Induced Directional Switch of a Molecular Motor Enables Parallel Microtubule Bundle Formation
    In: Cell Vol. 167 (2016) Nr. 2, pp. 539 - 552.e14
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Dahms, Sven O.; Arciniega, Marcelino; Steinmetzer, Torsten; Huber, Robert; Than, Manuel E.
    Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 113 (2016) Nr. 40, pp. 11196 - 11201
    Online Full Text: dx.doi.org/ (Open Access)
  • van den Boom, Johannes; Wolf, Markus; Weimann, Lena; Schulze, Nina; Li, Fanghua; Kaschani, Farnusch; Riemer, Anne; Zierhut, Christian; Kaiser, Markus; Iliakis, George; Funabiki, Hironori; Meyer, Hemmo
    VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair
    In: Molecular Cell Vol. 64 (2016) Nr. 1, pp. 189 - 198
    Online Full Text: dx.doi.org/ (Open Access)

    • 2015

  • Li, Mao; Schlesiger, Stefanie; Knauer, Shirley; Schmuck, Carsten
    A Tailor-Made Specific Anion-Binding Motif in the Side Chain Transforms a Tetrapeptide into an Efficient Vector for Gene Delivery
    In: Angewandte Chemie International Edition Vol. 54 (2015) Nr. 10, pp. 2941 - 2944
    Online Full Text: dx.doi.org/
  • Ilyas, Muhammad; Hörger, Anja C.; Bozkurt, Tolga O.; Burg, Harrold A. van den; Kaschani, Farnusch; Kaiser, Markus; Belhaj, Khaoula; Smoker, Matthew; Joosten, Matthieu H. A. J.; Kamoun, Sophien; Hoorn, Renier A. L. van der
    Functional divergence of two secreted immune proteases of tomato
    In: Current Biology Vol. 25 (2015) Nr. 17, pp. 2300 - 2306
    Online Full Text: dx.doi.org/ (Open Access)
  • Lump, Edina; Castellano, Laura M.; Meier, Christoph; Seeliger, Janine; Erwin, Nelli; Sperlich, Benjamin; Stürzel, Christina M.; Usmani, Shariq; Hammond, Rebecca M.; Einem, Jens von; Gerold, Gisa; Kreppel, Florian; Bravo-Rodriguez, Kenny; Pietschmann, Thomas; Holmes, Veronica M.; Palesch, David; Zirafi, Onofrio; Weissman, Drew; Sowislok, Andrea; Wettig, Burkhard; Heid, Christian; Kirchhoff, Frank; Weil, Tanja; Klärner, Frank-Gerrit; Schrader, Thomas; Bitan, Gal; Sánchez-García, Elsa; Winter, Roland; Shorter, James; Munch, Jan
    A molecular tweezer antagonizes seminal amyloids and HIV infection
    In: eLife Vol. 4 (2015) Nr. 8, pp. e05397
    Online Full Text: dx.doi.org/ (Open Access)
  • Overlack, Katharina; Primorac, Ivana; Vleugel, Mathijs; Krenn, Veronica; Maffini, Stefano; Hoffmann, Ingrid; Kops, Geert J. P. L.; Musacchio, Andrea
    A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint
    In: eLife Vol. 4 (2015) pp. e05269
    Online Full Text: dx.doi.org/ (Open Access)
  • Mieck, Christine; Molodtsov, Maxim I.; Drzewicka, Katarzyna; van der Vaart, Babet; Litos, Gabriele; Schmauss, Gerald; Vaziri, Alipasha; Westermann, Stefan
    Non-catalytic motor domains enable processive movement and functional diversification of the kinesin-14 Kar3
    In: eLife Vol. 4 (2015) pp. e04489
    Online Full Text: dx.doi.org/ (Open Access)
  • Beaufort, Nathalie; Scharrer, Eva; Lux, Vanda; Ehrmann, Michael; Haffner, Christof; Dichgans, Martin
    Reply to Liu et al. : Loss of TGF-β signaling in CARASIL pathogenesis
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 112 (2015) Nr. 14, pp. E1694
    Online Full Text: dx.doi.org/
  • Meyer, Rebecca; Sacca, Barbara; Niemeyer, Christof M.
    Site-Directed, on-surface assembly of DNA nanostructures
    In: Angewandte Chemie International Edition Vol. 54 (2015) Nr. 41, pp. 12039 - 12043
    Online Full Text: dx.doi.org/
  • Tachiwana, Hiroaki; Müller, Sebastian; Blümer, Julia; Klare, Kerstin; Musacchio, Andrea; Almouzni, Geneviève
    HJURP involvement in De Novo CenH3CENP-A and CENP-C recruitment
    In: Cell Reports Vol. 11 (2015) Nr. 1, pp. 22 - 32
    Online Full Text: dx.doi.org/ (Open Access)
  • Costa, Paolo; Trosien, Iris; Fernandez-Oliva, Miguel; Sánchez-García, Elsa; Sander, Wolfram
    The Fluorenyl Cation
    In: Angewandte Chemie International Edition Vol. 54 (2015) Nr. 9, pp. 2656 - 2660
    Online Full Text: dx.doi.org/
  • Musacchio, Andrea
    The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics
    In: Current Biology Vol. 25 (2015) Nr. 20, pp. R1002 - R1018
    Online Full Text: dx.doi.org/ (Open Access)
  • Budeus, Bettina; De Reynoso, Stefanie Schweigle; Przekopowitz, Martina; Hoffmann, Daniel; Seifert, Marc; Küppers, Ralf
    Complexity of the human memory B-cell compartment is determined by the versatility of clonal diversification in germinal centers
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 112 (2015) Nr. 38, pp. E5281 - E5289
    Online Full Text: dx.doi.org/ (Open Access)
  • Poepsel, Simon; Sprengel, Andreas; Sacca, Barbara; Kaschani, Farnusch; Kaiser, Markus; Gatsogiannis, Christos; Raunser, Stefan; Clausen, Tim; Ehrmann, Michael
    Determinants of amyloid fibril degradation by the PDZ protease HTRA1
    In: Nature Chemical Biology Vol. 11 (2015) Nr. 11, pp. 862 - 869
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Schneider, Maren; Hellerschmied, Doris; Schubert, Tobias; Amlacher, Stefan; Vinayachandran, Vinesh; Reja, Rohit; Pugh, B. Franklin; Clausen, Tim; Köhler, Alwin
    The Nuclear Pore-Associated TREX-2 Complex Employs Mediator to Regulate Gene Expression
    In: Cell Vol. 162 (2015) Nr. 5, pp. 1016 - 1028
    Online Full Text: dx.doi.org/ (Open Access)
  • Kellermann, Guillaume; Kaiser, Markus; Dingli, Florent; Lahuna, Olivier; Naud-Martin, Delphine; Mahuteau-Betzer, Florence; Loew, Damarys; Ségal-Bendirdjian, Évelyne; Teulade-Fichou, Marie-Paule; Bombard, Sophie
    Identification of human telomerase assembly inhibitors enabled by a novel method to produce hTERT
    In: Nucleic Acids Research Vol. 43 (2015) Nr. 15, art. no. e99
    Online Full Text: dx.doi.org/ (Open Access)
  • Kefalakes, Helenie; Budeus, Bettina; Walker, Andreas; Jochum, Christoph; Hilgard, Gudrun; Heinold, Andreas; Heinemann, Falko M.; Gerken, Guido; Hoffmann, Daniel; Timm, Jörg
    Adaptation of the Hepatitis B Virus Core Protein to CD8+ T-Cell Selection Pressure
    In: Hepatology Vol. 62 (2015) Nr. 1, pp. 47 - 56
    Online Full Text: dx.doi.org/ (Open Access)
  • Musacchio, Andrea
    Closing the Mad2 cycle : chromosome separation is regulated by a cycle that involves a protein undergoing an unusual topological conversion
    In: eLife Vol. 4 (2015) pp. e08283
    Online Full Text: dx.doi.org/ (Open Access)
  • Docter, Dominic; Westmeier, Dana; Markiewicz, Marta; Stolte, Stefan; Knauer, Shirley; Stauber, Roland H.
    The nanoparticle biomolecule corona : lessons learned – challenge accepted?
    In: Chemical Society Reviews Vol. 44 (2015) Nr. 17, pp. 6094 - 6121
    Online Full Text: dx.doi.org/ (Open Access)
  • Sacca, Barbara; Ishitsuka, Yuji; Meyer, Rebecca; Sprengel, Andreas; Schöneweiß, Elisa-Charlott; Nienhaus, G. Ulrich; Niemeyer, Christof M.
    Reversible reconfiguration of DNA origami nanochambers monitored by single-molecule FRET
    In: Angewandte Chemie International Edition Vol. 54 (2015) Nr. 12, pp. 3592 - 3597
    Online Full Text: dx.doi.org/
  • Faesen, Alex C.; Musacchio, Andrea
    The (phospho) needle in the (MELT) haystack
    In: Molecular Cell Vol. 57 (2015) Nr. 5, pp. 765 - 766
    Online Full Text: dx.doi.org/ (Open Access)
All ZMB publications