ZMB Site - Faculty of Biology
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Faculty of Biology
Selected Publications
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Alternating binding and p97-mediated dissociation of SDS22 and I3 recycles active PP1 between holophosphatasesIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 121 (2024) Nr. 36, e2408787121Online Full Text: dx.doi.org/ (Open Access)
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Role of protein kinase PLK1 in the epigenetic maintenance of centromeresIn: Science Vol. 385 (2024) Nr. 6713, pp. 1091 - 1097Online Full Text: dx.doi.org/
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A modular DNA origami nanocompartment for engineering a cell-free, protein unfolding and degradation pathwayIn: Nature Nanotechnology Vol. 19 (2024) Nr. 10, pp. 1521 - 1531Online Full Text: dx.doi.org/ (Open Access)
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Lysosomal damage sensing and lysophagy initiation by SPG20-ITCHIn: Molecular Cell (2024) pp. 1556 - 1569.e10Online Full Text: dx.doi.org/ (Open Access)
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Rational correction of pathogenic conformational defects in HTRA1In: Nature Communications Vol. 15 (2024) Nr. 1, 5944Online Full Text: dx.doi.org/ (Open Access)
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Microtubule end-on attachment maturation regulates Mps1 association with its kinetochore receptorIn: Current Biology Vol. 34 (2024) Nr. 11, pp. 2279 - 2293.e6Online Full Text: dx.doi.org/ (Open Access)
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The Endo-Lysosomal Damage ResponseIn: Annual Review of Biochemistry Vol. 93 (2024) Nr. 1, pp. 367 - 387Online Full Text: dx.doi.org/ (Open Access)
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A validation strategy to assess the role of phase separation as a determinant of macromolecular localizationIn: Molecular Cell Vol. 84 (2024) Nr. 9, pp. 1783 - 1801.e7Online Full Text: dx.doi.org/ (Open Access)
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TopBP1 utilises a bipartite GINS binding mode to support genome replicationIn: Nature Communications Vol. 15 (2024) Nr. 1, 1797Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access)
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Structure of the human KMN complex and implications for regulation of its assemblyIn: Nature Structural & Molecular Biology Vol. 31 (2024) Nr. 6, pp. 861 - 873Online Full Text: dx.doi.org/ (Open Access)
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Thirty years of structural changesIn: Nature Structural & Molecular Biology Vol. 31 (2024) Nr. 1, pp. 4 - 5Online Full Text: dx.doi.org/
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VCF1 is a p97/VCP cofactor promoting recognition of ubiquitylated p97-UFD1-NPL4 substratesIn: Nature Communications Vol. 15 (2024) Nr. 1, 2459Online Full Text: dx.doi.org/ (Open Access)
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RZZ‐Spindly and CENP‐E form an integrated platform to recruit dynein to the kinetochore coronaIn: The EMBO Journal Vol. 42 (2023) Nr. 24, e114838Online Full Text: dx.doi.org/
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Rho GTPase activity crosstalk mediated by Arhgef11 and Arhgef12 coordinates cell protrusion-retraction cyclesIn: Nature Communications Vol. 14 (2023) Nr. 1, 8356Online Full Text: dx.doi.org/ (Open Access)
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Spermine and spermidine bind CXCR4 and inhibit CXCR4- but not CCR5-tropic HIV-1 infectionIn: Science Advances Vol. 9 (2023) Nr. 27, eadf8251Online Full Text: dx.doi.org/ (Open Access)
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Chirality control of a single carbene molecule by tip-induced van der Waals interactionsIn: Nature Communications Vol. 14 (2023) Nr. 1, 4500Online Full Text: dx.doi.org/ (Open Access)
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Structure of the peroxisomal Pex1/Pex6 ATPase complex bound to a substrateIn: Nature Communications Vol. 14 (2023) Nr. 1, 5942Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access)
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Stable kinetochore-microtubule attachment requires loop-dependent Ndc80-Ndc80 bindingIn: The EMBO Journal Vol. 42 (2023) Nr. 13, e112504Online Full Text: dx.doi.org/ (Open Access)
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Structural basis of ubiquitin-independent PP1 complex disassembly by p97In: The EMBO Journal Vol. 42 (2023) Nr. 14, e113110Online Full Text: dx.doi.org/ (Open Access)
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Clp-targeting BacPROTACs impair mycobacterial proteostasis and survivalIn: Cell Vol. 186 (2023) Nr. 10, pp. 2176 - 2192.e22Online Full Text: dx.doi.org/ (Open Access)
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The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPaseIn: Nature Communications Vol. 14 (2023) Nr. 1, 3258Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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The structural flexibility of MAD1 facilitates the assembly of the Mitotic Checkpoint ComplexIn: Nature Communications Vol. 14 (2023) Nr. 1, 1529Online Full Text: dx.doi.org/ (Open Access)
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An allosteric HTRA1-calpain 2 complex with restricted activation profileIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 119 (2022) Nr. 14, e2113520119Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Identification of fungal lignocellulose-degrading biocatalysts secreted by Phanerochaete chrysosporium via activity-based protein profilingIn: Communications Biology Vol. 5 (2022) Nr. 1, 1254Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Erratum: Author Correction: Identification of fungal lignocellulose-degrading biocatalysts secreted by Phanerochaete chrysosporium via activity-based protein profiling (Communications biology (2022) 5 1 (1254))In: Communications Biology Vol. 5 (2022) Nr. 1, pp. 1319Online Full Text: dx.doi.org/ (Open Access)
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Chemoproteomics‐Enabled Identification of 4‐Oxo‐β‐Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9In: Angewandte Chemie International Edition Vol. 61 (2022) Nr. 47, e202210498Online Full Text: dx.doi.org/ (Open Access)
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Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repairIn: EMBO Reports Vol. 23 (2022) Nr. 10, e54136Online Full Text: dx.doi.org/ (Open Access)
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Persister state-directed transitioning and vulnerability in melanomaIn: Nature Communications Vol. 13 (2022) Nr. 1, 3055Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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BacPROTACs mediate targeted protein degradation in bacteriaIn: Cell Vol. 185 (2022) Nr. 13, pp. 2338 - 2353.e18Online Full Text: dx.doi.org/ (Open Access)
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On the role of phase separation in the biogenesis of membraneless compartmentsIn: The EMBO Journal Vol. 41 (2022) Nr. 5, e109952Online Full Text: dx.doi.org/ (Open Access)
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Structure of the RZZ complex and molecular basis of Spindly‐driven corona assembly at human kinetochoresIn: The EMBO Journal Vol. 41 (2022) Nr. 9, e110411Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transitionIn: Molecular Cell Vol. 82 (2022) Nr. 18, pp. 3350 - 3365.e7Online Full Text: dx.doi.org/ (Open Access)
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Ubiquitin profiling of lysophagy identifies actin stabilizer CNN2 as a target of VCP/p97 and uncovers a link to HSPB1In: Molecular Cell Vol. 82 (2022) Nr. 14, pp. 2633 - 2649.e7Online Full Text: dx.doi.org/ (Open Access)
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Structure of the human inner kinetochore CCAN complex and its significance for human centromere organizationIn: Molecular Cell Vol. 82 (2022) Nr. 11, pp. 2113 - 2131.e8Online Full Text: dx.doi.org/ (Open Access)
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Surface Diffusion Aided by a Chirality Change of Self-Assembled Oligomers under 2D ConfinementIn: Angewandte Chemie International Edition Vol. 61 (2022) Nr. 43, e202212245Online Full Text: dx.doi.org/ (Open Access)
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The role of DNA nanostructures in the catalytic properties of an allosterically regulated proteaseIn: Science Advances Vol. 8 (2022) Nr. 1, abk0425Online Full Text: dx.doi.org/ (Open Access)
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Cdc4 phospho-degrons allow differential regulation of ame1ceⁿp⁻u protein stability across the cell cycleIn: eLife Vol. 10 (2021) e67390Online Full Text: dx.doi.org/ (Open Access)
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Overlap of NatA and IAP substrates implicates N-terminal acetylation in protein stabilizationIn: Science Advances Vol. 7 (2021) Nr. 3, pp. eabc8590Online Full Text: dx.doi.org/ (Open Access)
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Targeted substrate loop insertion by VCP/p97 during PP1 complex disassemblyIn: Nature Structural & Molecular Biology Vol. 28 (2021) Nr. 12, pp. 964 - 971Online Full Text: dx.doi.org/
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Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezersIn: Nature Communications Vol. 12 (2021) Nr. 1, pp. 1505Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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CDC20 assists its catalytic incorporation in the mitotic checkpoint complexIn: Science Vol. 371 (2021) Nr. 6524, pp. 67 - 71Online Full Text: dx.doi.org/
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BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in MitosisIn: Molecular Cell Vol. 81 (2021) Nr. 1, pp. 67 - 87.e9Online Full Text: dx.doi.org/ (Open Access)
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Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasisIn: Cell Reports Vol. 37 (2021) Nr. 8, 110056Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Computational modeling and experimental validation of the EPI-X4/CXCR4 complex allows rational design of small peptide antagonistsIn: Communications Biology Vol. 4 (2021) Nr. 1, 1113Online Full Text: dx.doi.org/ (Open Access)
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Assembly principles and stoichiometry of a complete human kinetochore moduleIn: Science Advances Vol. 7 (2021) Nr. 27, eabg1037Online Full Text: dx.doi.org/ (Open Access)
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Phospho-regulated Bim1/EB1 interactions trigger Dam1c ring assembly at the budding yeast outer kinetochoreIn: The EMBO Journal Vol. 40 (2021) Nr. 18, e108004Online Full Text: dx.doi.org/ (Open Access)
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Rational prioritization strategy allows the design of macrolide derivatives that overcome antibiotic resistanceIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 118 (2021) Nr. 46, e2113632118Online Full Text: dx.doi.org/ (Open Access)
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Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infectionIn: Nature Communications Vol. 12 (2021) Nr. 1, pp. 1726Online Full Text: dx.doi.org/ (Open Access)
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Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assembliesIn: Science Advances Vol. 7 (2021) Nr. 2, pp. eabd4413Online Full Text: dx.doi.org/ (Open Access)
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UMI or not UMI, that is the question for scRNA-seq zero-inflationIn: Nature Biotechnology Vol. 39 (2021) Nr. 2, pp. 158 - 159Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Peptide and peptide-based inhibitors of SARS-CoV-2 entryIn: Advanced Drug Delivery Reviews Vol. 167 (2020) pp. 47 - 65Online Full Text: dx.doi.org/ (Open Access)
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Optogenetic Tuning Reveals Rho Amplification-Dependent Dynamics of a Cell Contraction Signal NetworkIn: Cell Reports Vol. 33 (2020) Nr. 9, pp. 108467Online Full Text: dx.doi.org/ (Open Access)
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Predominance of Central Memory T Cells with High T-Cell Receptor Repertoire Diversity is Associated with Response to PD-1/PD-L1 Inhibition in Merkel Cell CarcinomaIn: Clinical Cancer Research Vol. 26 (2020) Nr. 9, pp. 2257 - 2267Online Full Text: dx.doi.org/ (Open Access)
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A precisely positioned MED12 activation helix stimulates CDK8 kinase activityIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 117 (2020) Nr. 6, pp. 2894 - 2905Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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A Supramolecular Stabilizer of the 14-3-3ζ/ERα Protein-Protein Interaction with a Synergistic Mode of ActionIn: Angewandte Chemie International Edition Vol. 132 (2020) Nr. 13, pp. 5322 - 5325Online Full Text: dx.doi.org/ (Open Access)
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Auto-inhibition of Mif2/CENP-C ensures centromere-dependent kinetochore assembly in budding yeastIn: The EMBO Journal Vol. 39 (2020) Nr. 14, pp. e102938Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactionsIn: Nature Communications Vol. 11 (2020) Nr. 1, pp. 3954Online Full Text: dx.doi.org/ (Open Access)
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Functional Disruption of the Cancer-Relevant Interaction between Survivin and Histone H3 with a Guanidiniocarbonyl Pyrrole LigandIn: Angewandte Chemie International Edition Vol. 59 (2020) Nr. 14, pp. 5567 - 5571Online Full Text: dx.doi.org/ (Open Access)
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Activation by substoichiometric inhibitionIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 117 (2020) Nr. 3, pp. 1414 - 1418Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensingIn: Nature Communications Vol. 10 (2019) Nr. 1, pp. 4046Online Full Text: dx.doi.org/ (Open Access)
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A newly discovered stem cell that keeps bones growingIn: Nature Vol. 567 (2019) Nr. 7747, pp. 178 - 179Online Full Text: dx.doi.org/ (Open Access)
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The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal damageIn: EMBO Reports (2019) pp. e48014Online Full Text: dx.doi.org/ (Open Access)
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Electroporated recombinant proteins as tools for in vivo functional complementation, imaging and chemical biologyIn: eLife Vol. 8 (2019) pp. e48287Online Full Text: dx.doi.org/ (Open Access)
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Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing : Implications for the design of improved nanoantibioticsIn: Biomaterials Vol. 192 (2019) pp. 551 - 559Online Full Text: dx.doi.org/
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Control of TLR7-mediated type i IFN signaling in pDCs through CXCR4 engagement - A new target for lupus treatmentIn: Science Advances Vol. 5 (2019) Nr. 7, pp. eaav9019Online Full Text: dx.doi.org/ (Open Access)
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Molecular determinants of the Ska-Ndc80 interaction and their influence on microtubule tracking and force-couplingIn: eLife Vol. 8 (2019) pp. e49539Online Full Text: dx.doi.org/ (Open Access)
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Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosinIn: Nature Communications Vol. 10 (2019) Nr. 1, 4781Online Full Text: dx.doi.org/ (Open Access)
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Viral escape contributes to the failure of hepatitis D virus-specific CD8+ T-cells and drives evolution of HDVIn: Journal of Hepatology Vol. 70 (2019) Nr. Suppl. 1, pp. e21Online Full Text: dx.doi.org/
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Mutations in Hepatitis D Virus Allow It to Escape Detection by CD8⁺ T Cells and Evolve at the Population LevelIn: Gastroenterology Vol. 156 (2019) Nr. 6, pp. 1820 - 1833Online Full Text: dx.doi.org/ (Open Access)
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Glycosidase and glycan polymorphism control hydrolytic release of immunogenic flagellin peptidesIn: Science Vol. 364 (2019) Nr. 6436, eaav0748Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Sites of high local frustration in DNA origamiIn: Nature Communications Vol. 10 (2019) Nr. 1, pp. 1061Online Full Text: dx.doi.org/ (Open Access)
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Trade-off shapes diversity in eco-evolutionary dynamicsIn: eLife Vol. 7 (2018) pp. e36273Online Full Text: dx.doi.org/ (Open Access)
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Cell entry of a host-targeting protein of oomycetes requires gp96In: Nature Communications Vol. 9 (2018) Nr. 1, pp. 2347Online Full Text: dx.doi.org/ (Open Access)
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Nanomaterial-microbe cross-talk : physicochemical principles and (patho)biological consequencesIn: Chemical Society Reviews Vol. 47 (2018) Nr. 14, pp. 5312 - 5337Online Full Text: dx.doi.org/
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Proteolytic processing of palmitoylated Hedgehog peptides specifies the 3-4 intervein region of the Drosophila wingIn: eLife Vol. 7 (2018) pp. e33033Online Full Text: dx.doi.org/ (Open Access)
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UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteinsIn: Nature Communications Vol. 9 (2018) Nr. 1, 484Online Full Text: dx.doi.org/ (Open Access)
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Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80.In: Molecular Cell Vol. 71 (2018) Nr. 6, pp. 923 - 939.e10Online Full Text: dx.doi.org/ (Open Access)
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Nanoparticle decoration impacts airborne fungal pathobiologyIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 115 (2018) Nr. 27, pp. 7087 - 7092Online Full Text: dx.doi.org/ (Open Access)
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Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancerIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 115 (2018) Nr. 7, pp. E1437 - E1445Online Full Text: dx.doi.org/ (Open Access)
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Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme FormationIn: Molecular Cell Vol. 72 (2018) Nr. 4, pp. 766 - 777Online Full Text: dx.doi.org/ (Open Access)
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BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligandsIn: eLife Vol. 7 (2018) pp. e39979Online Full Text: dx.doi.org/ (Open Access)
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A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPasesIn: Angewandte Chemie International Edition Vol. 57 (2018) Nr. 6, pp. 1576 - 1580Online Full Text: dx.doi.org/
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Evolution of the Optical Gap in the Acene Series : UndecaceneIn: Angewandte Chemie International Edition Vol. 57 (2018) Nr. 33, pp. 10506 - 10509Online Full Text: dx.doi.org/
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Small Meets Smaller : Effects of Nanomaterials on Microbial Biology, Pathology, and EcologyIn: ACS Nano Vol. 12 (2018) Nr. 7, pp. 6351 - 6359Online Full Text: dx.doi.org/
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Biased IGH VDJ gene repertoire and clonal expansions in B cells of chronically hepatitis C virus–infected individualsIn: Blood Vol. 131 (2018) Nr. 5, pp. 546 - 557Online Full Text: dx.doi.org/ (Open Access)
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Hierarchical Assembly of DNA Filaments with Designer Elastic PropertiesIn: ACS Nano Vol. 12 (2018) Nr. 1, pp. 44 - 55Online Full Text: dx.doi.org/
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Crystal structure and mechanism of human carboxypeptidase O : Insights into its specific activity for acidic residuesIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 115 (2018) Nr. 17, pp. E3932 - E3939Online Full Text: dx.doi.org/ (Open Access)
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VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and SignalingIn: Molecular Cell Vol. 69 (2018) Nr. 2, pp. 182 - 194Online Full Text: dx.doi.org/ (Open Access)
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Basis of catalytic assembly of the mitotic checkpoint complexIn: Nature Vol. 542 (2017) Nr. 7642, pp. 498 - 502Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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BubR1 Promotes Bub3-Dependent APC/C Inhibition during Spindle Assembly Checkpoint SignalingIn: Current Biology Vol. 27 (2017) Nr. 19, pp. 2915 - 2927.e7Online Full Text: dx.doi.org/ (Open Access)
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Tailored Ahp-cyclodepsipeptides as Potent Non-covalent Serine Protease InhibitorsIn: Angewandte Chemie International Edition Vol. 56 (2017) Nr. 29, Special Issue: 100th Anniversary of the Royal Australian Chemical Institute, pp. 8555 - 8558Online Full Text: dx.doi.org/
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CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loadingIn: eLife Vol. 6 (2017) pp. e23352Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Detection and Clearance of Damaged Lysosomes by the Endo-Lysosomal Damage Response and LysophagyIn: Current Biology Vol. 27 (2017) Nr. 24, pp. R1330 - R1341Online Full Text: dx.doi.org/
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Decoding the centromeric nucleosome through CENP-NIn: eLife Vol. 6 (2017) pp. e33442Online Full Text: dx.doi.org/ (Open Access)
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Activity-based protein profiling as a robust method for enzyme identification and screening in extremophilic ArchaeaIn: Nature Communications Vol. 8 (2017) pp. 15352Online Full Text: dx.doi.org/ (Open Access)
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Molecular basis for inner kinetochore configuration through RWD domain–peptide interactionsIn: The EMBO Journal Vol. 36 (2017) Nr. 23, pp. 3458 - 3482Online Full Text: dx.doi.org/ (Open Access)
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The greatest kinetochore show on earthIn: EMBO Reports Vol. 18 (2017) Nr. 9, pp. 1473 - 1475Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Efficient Gene Transfection through Inhibition of β-Sheet (Amyloid Fiber) Formation of a Short Amphiphilic Peptide by Gold NanoparticlesIn: Angewandte Chemie International Edition Vol. 56 (2017) Nr. 28, pp. 8083 - 8088Online Full Text: dx.doi.org/
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Morphology-Dependent Cell Imaging by Using a Self-Assembled Diacetylene Peptide AmphiphileIn: Angewandte Chemie International Edition Vol. 56 (2017) Nr. 46, pp. 14526 - 14530Online Full Text: dx.doi.org/
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Tailored protein encapsulation into a DNA host using geometrically organized supramolecular interactionsIn: Nature Communications Vol. 8 (2017) pp. 14472Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagyIn: The EMBO Journal Vol. 36 (2017) Nr. 2, pp. 135 - 150Online Full Text: dx.doi.org/ (Open Access)
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Targeting of the Fun30 nucleosome remodeller by the Dpb11 scaffold facilitates cell cycle-regulated DNA end resectionIn: eLife (2017) Nr. 6, pp. e21687Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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CCAN Assembly Configures Composite Binding Interfaces to Promote Cross-Linking of Ndc80 Complexes at the KinetochoreIn: Current Biology Vol. 26 (2016) Nr. 17, pp. 2370 - 2378Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Competitive solvent-molecule interactions govern primary processes of diphenylcarbene in solvent mixturesIn: Nature Communications Vol. 7 (2016) pp. 12968Online Full Text: dx.doi.org/ (Open Access)
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BiGBac enables rapid gene assembly for the expression of large multisubunit protein complexesIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 113 (2016) Nr. 19, pp. E2564 - E2569Online Full Text: dx.doi.org/ (Open Access)
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Modular PROTAC Design for the Degradation of Oncogenic BCR-ABLIn: Angewandte Chemie International Edition Vol. 55 (2016) Nr. 2, pp. 807 - 810Online Full Text: dx.doi.org/
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Insights from biochemical reconstitution into the architecture of human kinetochoresIn: Nature Vol. 537 (2016) Nr. 7619, pp. 249 - 253Online Full Text: dx.doi.org/
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A Force-Induced Directional Switch of a Molecular Motor Enables Parallel Microtubule Bundle FormationIn: Cell Vol. 167 (2016) Nr. 2, pp. 539 - 552.e14Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Characterizing the Effect of Multivalent Conjugates Composed of Aβ-Specific Ligands and Metal Nanoparticles on Neurotoxic Fibrillar AggregationIn: ACS Nano (2016) pp. 7582 - 7597Online Full Text: dx.doi.org/
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Molecular requirements for the inter-subunit interaction and kinetochore recruitment of SKAP and AstrinIn: Nature Communications Vol. 7 (2016) pp. 11407Online Full Text: dx.doi.org/ (Open Access)
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Microtubules : 50 years on from the discovery of tubulinIn: Nature Reviews Molecular Cell Biology Vol. 17 (2016) Nr. 5, pp. 322 - 328Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamersIn: Nature Communications Vol. 7 (2016) pp. 13047Online Full Text: dx.doi.org/ (Open Access)
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Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanismIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 113 (2016) Nr. 40, pp. 11196 - 11201Online Full Text: dx.doi.org/ (Open Access)
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Molecular basis of outer kinetochore assembly on CENP-TIn: eLife Vol. 5 (2016) pp. e21007Online Full Text: dx.doi.org/ (Open Access)
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Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human KinetochoresIn: Cell Vol. 167 (2016) Nr. 4, pp. 1028 - 1040.e15Online Full Text: dx.doi.org/ (Open Access)
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VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break RepairIn: Molecular Cell Vol. 64 (2016) Nr. 1, pp. 189 - 198Online Full Text: dx.doi.org/ (Open Access)
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Incorporation of a Non-Natural Arginine Analogue into a Cyclic Peptide Leads to Formation of Positively Charged Nanofibers Capable of Gene TransfectionIn: Angewandte Chemie International Edition Vol. 55 (2016) Nr. 2, pp. 598 - 601Online Full Text: dx.doi.org/
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Complexity of the human memory B-cell compartment is determined by the versatility of clonal diversification in germinal centersIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 112 (2015) Nr. 38, pp. E5281 - E5289Online Full Text: dx.doi.org/ (Open Access)
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Determinants of amyloid fibril degradation by the PDZ protease HTRA1In: Nature Chemical Biology Vol. 11 (2015) Nr. 11, pp. 862 - 869Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Functional divergence of two secreted immune proteases of tomatoIn: Current Biology Vol. 25 (2015) Nr. 17, pp. 2300 - 2306Online Full Text: dx.doi.org/ (Open Access)
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The Fluorenyl CationIn: Angewandte Chemie International Edition Vol. 54 (2015) Nr. 9, pp. 2656 - 2660Online Full Text: dx.doi.org/
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A molecular tweezer antagonizes seminal amyloids and HIV infectionIn: eLife Vol. 4 (2015) Nr. 8, pp. e05397Online Full Text: dx.doi.org/ (Open Access)
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The Nuclear Pore-Associated TREX-2 Complex Employs Mediator to Regulate Gene ExpressionIn: Cell Vol. 162 (2015) Nr. 5, pp. 1016 - 1028Online Full Text: dx.doi.org/ (Open Access)
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Identification of human telomerase assembly inhibitors enabled by a novel method to produce hTERTIn: Nucleic Acids Research Vol. 43 (2015) Nr. 15, art. no. e99Online Full Text: dx.doi.org/ (Open Access)
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Adaptation of the Hepatitis B Virus Core Protein to CD8+ T-Cell Selection PressureIn: Hepatology Vol. 62 (2015) Nr. 1, pp. 47 - 56Online Full Text: dx.doi.org/ (Open Access)
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The Molecular Biology of Spindle Assembly Checkpoint Signaling DynamicsIn: Current Biology Vol. 25 (2015) Nr. 20, pp. R1002 - R1018Online Full Text: dx.doi.org/ (Open Access)
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Reply to Liu et al. : Loss of TGF-β signaling in CARASIL pathogenesisIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 112 (2015) Nr. 14, pp. E1694Online Full Text: dx.doi.org/
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The nanoparticle biomolecule corona : lessons learned – challenge accepted?In: Chemical Society Reviews Vol. 44 (2015) Nr. 17, pp. 6094 - 6121Online Full Text: dx.doi.org/ (Open Access)
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A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpointIn: eLife Vol. 4 (2015) pp. e05269Online Full Text: dx.doi.org/ (Open Access)
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Non-catalytic motor domains enable processive movement and functional diversification of the kinesin-14 Kar3In: eLife Vol. 4 (2015) pp. e04489Online Full Text: dx.doi.org/ (Open Access)
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Reversible reconfiguration of DNA origami nanochambers monitored by single-molecule FRETIn: Angewandte Chemie International Edition Vol. 54 (2015) Nr. 12, pp. 3592 - 3597Online Full Text: dx.doi.org/
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A Tailor-Made Specific Anion-Binding Motif in the Side Chain Transforms a Tetrapeptide into an Efficient Vector for Gene DeliveryIn: Angewandte Chemie International Edition Vol. 54 (2015) Nr. 10, pp. 2941 - 2944Online Full Text: dx.doi.org/
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Site-Directed, on-surface assembly of DNA nanostructuresIn: Angewandte Chemie International Edition Vol. 54 (2015) Nr. 41, pp. 12039 - 12043Online Full Text: dx.doi.org/
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Closing the Mad2 cycle : chromosome separation is regulated by a cycle that involves a protein undergoing an unusual topological conversionIn: eLife Vol. 4 (2015) pp. e08283Online Full Text: dx.doi.org/ (Open Access)
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The (phospho) needle in the (MELT) haystackIn: Molecular Cell Vol. 57 (2015) Nr. 5, pp. 765 - 766Online Full Text: dx.doi.org/ (Open Access)
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HJURP involvement in De Novo CenH3CENP-A and CENP-C recruitmentIn: Cell Reports Vol. 11 (2015) Nr. 1, pp. 22 - 32Online Full Text: dx.doi.org/ (Open Access)