Mechanistic Cell Biology

Prof. Dr. Doris Hellerschmied-Jelinek

Group Leader Mechanistic Cell Biology
  • +49 (0)201 183-3120
  • Doris.Hellerschmied@uni-due.de
  • S05 T04 B30

Faculty of Biology

Universität Duisburg-Essen
45141 Essen

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© Hellerschmied

Research

Chemical Biology to Unravel Protein Homeostasis

Understanding how cells maintain homeostasis is critical to understanding cell survival during stress. Cells have to withstand stress from changing environmental conditions, such as temperature, pH, nutrient or oxygen supply, but also during cell differentiation and aging. Eukaryotic cells have evolved to use distinct cellular compartments, known as organelles, which maintain homeostatic mechanisms to ensure their distinct functionalities and overall cellular homeostasis. Within the secretory pathway, these stress response mechanisms have been extensively studied at the level of the endoplasmic reticulum (ER). In contrast, the mechanism(s) by which the Golgi apparatus deals with unfolded proteins and how it reacts to stress are only beginning to be unraveled.

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Selected Publications

Abraham Pol, Savina; Liljenberg, Sara; Barr, Jack; Simon, Gina; Wong-Dilworth, Luis; Paterson, Danielle L.; Berishvili, Vladimir P.; Bottanelli, Francesca; Kaschani, Farnusch; Kaiser, Markus; Pettersson, Mariell; Hellerschmied, Doris.
Induced degradation of SNAP-fusion proteins. (2024)
RSC Chem. Biol. DOI: 10.1039/D4CB00184B

Brenner, Joel Cyrille; Zirden, Linda; Almeida-Hernandez, Yasser; Kaschani, Farnusch; Kaiser, Markus; Sanchez-Garcia, Elsa; Poepsel, Simon; Hellerschmied-Jelinek, Doris.
Conformational plasticity of a BiP-GRP94 chaperone complex. (2024)
biorxiv DOI: 10.1101/2024.02.01.578445

Buzuk, Lana; Hellerschmied, Doris.
Ubiquitin-mediated degradation at the Golgi apparatus. (2023)
Frontiers in Molecular Biosciences Vol. 10 DOI: 10.3389/fmolb.2023.1197921

Diamantino, João; Hellerschmied, Doris.
Cellular Principles of Targeted Protein Degradation. (2023)
In Philipp Cromm (Editor): Inducing Targeted Protein Degradation. Wiley, S. 25–62. DOI: 10.1002/9783527836208.ch2

Schillinger, Jasmin; Hellerschmied, Doris.
Targeted Protein Unfolding at the Golgi Apparatus. (2023)
Methods in Molecular Biology 2557, S. 645–659. DOI: 10.1007/978-1-0716-2639-9_39