ZMB Member Farnusch Kaschani
ZMB Member
Farnusch Kaschani
Next ZMB-Member
Dr. Farnusch Kaschani
Group Chemical Proteomics
Analytics Core Facility Essen (ACE)Center of Medical Biotechnology (ZMB)
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen
- +49 201 183 4924
- Website
- CV
- Selected Publications
- ZMB Research Program
Molecular and Chemical Cell Biology
Research Overview
The Analytics Core Facility Essen (ACE) is a central facility of the Center of Medical Biotechnology (ZMB) and of the Faculty of Biology of the University Duisburg-Essen. It offers access to state-of-the-art mass spectrometry-based proteomics for internal and external users. The timely technical equipment of the ACE allows us to provide a wide variety of different “bottom-up” and “top-down” proteomics methods. Furthermore, we also develop innovative solutions for project-specific demands. The service comprises all aspects of mass spectrometry-based proteomics, starting from technical advice and project planning, sample preparation and analysis to data analysis, data management and interpretation of results. We are also listed in the RIsources Poral of the DFG (RI_00466).
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Selected Publications
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Extracellular plant subtilases dampen cold-shock peptide elicitor levelsIn: Nature Plants (2024) in pressOnline Full Text: dx.doi.org/ (Open Access)
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TopBP1 utilises a bipartite GINS binding mode to support genome replicationIn: Nature Communications Vol. 15 (2024) Nr. 1, 1797Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access)
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Clp-targeting BacPROTACs impair mycobacterial proteostasis and survivalIn: Cell Vol. 186 (2023) Nr. 10, pp. 2176 - 2192.e22Online Full Text: dx.doi.org/ (Open Access)
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Structure of the peroxisomal Pex1/Pex6 ATPase complex bound to a substrateIn: Nature Communications Vol. 14 (2023) Nr. 1, 5942Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access)
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The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPaseIn: Nature Communications Vol. 14 (2023) Nr. 1, 3258Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Persister state-directed transitioning and vulnerability in melanomaIn: Nature Communications Vol. 13 (2022) Nr. 1, 3055Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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An apoplastic peptide activates salicylic acid signalling in maizeIn: Nature Plants Vol. 4 (2018) Nr. 3, pp. 172 - 180Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme FormationIn: Molecular Cell Vol. 72 (2018) Nr. 4, pp. 766 - 777Online Full Text: dx.doi.org/ (Open Access)
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Activity-based protein profiling as a robust method for enzyme identification and screening in extremophilic ArchaeaIn: Nature Communications Vol. 8 (2017) pp. 15352Online Full Text: dx.doi.org/ (Open Access)
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VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break RepairIn: Molecular Cell Vol. 64 (2016) Nr. 1, pp. 189 - 198Online Full Text: dx.doi.org/ (Open Access)
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Determinants of amyloid fibril degradation by the PDZ protease HTRA1In: Nature Chemical Biology Vol. 11 (2015) Nr. 11, pp. 862 - 869Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Journal articles
Curriculum Vitae
Professional appointments | ||
Since 2013 | Group leader “Chemical Proteomics”, University of Duisburg-Essen, Germany.
Head of Analytics Core Facility (ACE), University of Duisburg-Essen, Germany |
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2011–2012 | Lab-manager and Senior Postdoc in the group of Prof. Kaiser at the University of Duisburg-Essen. Responsible for proteomics and target identification as well as laboratory management. | |
2006–2011 | Senior Postdoc in the Plant Chemetics Lab of Dr. Renier van der Hoorn at the Max-Planck-Institute for Plant Breeding Research in Cologne. |
Academic degrees | ||
2001 - 2005 | PhD thesis at the Max-Planck-Institute for Plant Breeding Research in Cologne in the department of Prof. Heinz Saedler | |
1995 - 2000 | Study of Chemistry at the Julius Maximilians-Universität Würzburg and at the Queensland University of Technology (QUT) in Brisbane, Australia. | |
Honours | ||
2012 | Grant of the rectorate of the University Duisburg-Essen ("Rektoratsprogramm zur Förderung des wissenschaftlichen Nachwuchses", 01.08.2012 - 30.09.2013 25000€).
Poster Price of the International Biometals society for best Poster presented at the 8th International Symposium on Biometals in Brussels Belgium Travel grant from the DAAD to attend the 8th International Symposium on Biometals in Brussels Belgium (15.-19.07.2012). The grant covered all travelling costs and registration fees. |
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2009 | Travel grant from the DAAD to attend the IV International Symposium on Biochemistry and Molecular Biology, Havana, Cuba (12.-16.10.2009). The grant covered all travelling costs and registration fees.
Travel grant from the New Phytologist Trust to attend the 22th New Phytologist Symposium on Effectors in Plant-microbe interactions, Paris, France (13.-16.09.2009). The grant covered all travelling costs and registration fees. |
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