ZMB Member Farnusch Kaschani

ZMB Member
Farnusch Kaschani

Next ZMB-Member
portrait photo of ZMB member Farnusch Kaschani
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Dr. Farnusch Kaschani

Group Chemical Proteomics

Analytics Core Facility Essen (ACE)

Center of Medical Biotechnology (ZMB)
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen

Research Overview

The Analytics Core Facility Essen (ACE) is a central facility of the Center of Medical Biotechnology (ZMB) and of the Faculty of Biology of the University Duisburg-Essen. It offers access to state-of-the-art mass spectrometry-based proteomics for internal and external users. The timely technical equipment of the ACE allows us to provide a wide variety of different “bottom-up” and “top-down” proteomics methods. Furthermore, we also develop innovative solutions for project-specific demands. The service comprises all aspects of mass spectrometry-based proteomics, starting from technical advice and project planning, sample preparation and analysis to data analysis, data management and interpretation of results. We are also listed in the RIsources Poral of the DFG (RI_00466).
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Selected Publications

    Journal articles

  • Sueldo, Daniela J.; Godson, Alice; Kaschani, Farnusch; Krahn, Daniel; Kessenbrock, Till; Buscaill, Pierre; Schofield, Christopher J.; Kaiser, Markus; van der Hoorn, Renier A. L.
    Activity-based proteomics uncovers suppressed hydrolases and a neo-functionalised antibacterial enzyme at the plant–pathogen interface
    In: New Phytologist Vol. 241 (2024) Nr. 1, pp. 394 - 408
  • Kaplieva-Dudek, I.; Samak, Nadia; Bormann, Jenny; Kaschani, Farnusch; Kaiser, Markus; Meckenstock, Rainer.
    Characterization of 2-phenanthroate:CoA ligase from the sulfate-reducing, phenanthrene-degrading enrichment culture TRIP
    In: Applied and Environmental Microbiology Vol. 90 (2024) Nr. 10, e0129624
  • Sowislok, Andrea; Busch, André; Kaschani, Farnusch; Kaiser, Markus; Jäger, Marcus.
    Differences in the Synovial Fluid Proteome of Septic and Aseptic Implant Failure
    In: Antibiotics Vol. 13 (2024) Nr. 4, 346
  • Font-Farre, Maria; Brown, Daniel; Toth, Reka; Mahadevan, Chidambareswaren; Brazier-Hicks, Melissa; Morimoto, Kyoko; Kaschani, Farnusch; Sinclair, John; Dale, Richard; Hall, Samantha; Morris, Melloney; Kaiser, Markus; Wright, Aaron T.; Burton, Jonathan; van et al.
    Discovery of active mouse, plant and fungal cytochrome P450s in endogenous proteomes and upon expression in planta
    In: Scientific Reports Vol. 14 (2024) Nr. 1, 10091
  • Ninck, Sabrina; Klaus, Thomas; Kochetkova, Tatiana V.; Esser, Sarah P.; Sewald, Leonard; Kaschani, Farnusch; Bräsen, Christopher; Probst, Alexander J.; Kublanov, Ilya V.; Siebers, Bettina; Kaiser, Markus.
    Environmental activity-based protein profiling for function-driven enzyme discovery from natural communities
    In: Environmental Microbiomes Vol. 19 (2024) Nr. 1, 36
  • Chen, Changlong; Buscaill, Pierre; Sanguankiattichai, Nattapong; Huang, Jie; Kaschani, Farnusch; Kaiser, Markus; van der Hoorn, Renier A. L.
    Extracellular plant subtilases dampen cold-shock peptide elicitor levels
    In: Nature Plants Vol. 10 (2024) Nr. 11, pp. 1749 - 1760
  • Parsons, Jack D.; Cocker, Clare R.; East, Alison K.; Wheatley, Rachel M.; Ramachandran, Vinoy K.; Kaschani, Farnusch; Kaiser, Markus; Poole, Philip S.
    Factors governing attachment of Rhizobium leguminosarum to legume roots at acid, neutral, and alkaline pHs
    In: mSystems Vol. 9 (2024) Nr. 9, e0042224
  • Font Farre, Maria; Brown, Daniel; König, Maurice; Killinger, Brian J.; Kaschani, Farnusch; Kaiser, Markus; Wright, Aaron T.; Burton, Jonathan; van der Hoorn, Renier A.L.
    Glutathione Transferase Photoaffinity Labeling Displays GST Induction by Safeners and Pathogen Infection
    In: Plant and Cell Physiology Vol. 65 (2024) Nr. 1, pp. 128 - 141
  • Schillinger, Jasmin; Koci, Michelle; Bravo-Rodriguez, Kenny; Heilmann, Geronimo; Kaschani, Farnusch; Kaiser, Markus; Beuck, Christine; Luecke, Hartmut; Huber, Robert; Hellerschmied-Jelinek, Doris; Burston, Steven G.; Ehrmann, Michael.
    High resolution analysis of proteolytic substrate processing
    In: The Journal of Biological Chemistry (JBC) Vol. 300 (2024) Nr. 11, 107812
  • Pol, Savina Abraham; Liljenberg, Sara; Barr, Jack; Simon, Gina; Wong-Dilworth, Luis; Paterson, Danielle L.; Berishvili, Vladimir P.; Bottanelli, Francesca; Kaschani, Farnusch; Kaiser, Markus; Pettersson, Mariell; Hellerschmied, Doris.
    Induced degradation of SNAP-fusion proteins
    In: RSC Chemical Biology Vol. 5 (2024) Nr. 12, pp. 1232 - 1247
  • Pleuger, Richard; Cozma, Christian; Hohoff, Simone; Denkhaus, Christian; Dudziak, Alexander; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Vetter, Ingrid R.; Westermann, Stefan.
    Microtubule end-on attachment maturation regulates Mps1 association with its kinetochore receptor
    In: Current Biology Vol. 34 (2024) Nr. 11, pp. 2279 - 2293.e6
  • Buscaill, Pierre; Sanguankiattichai, Nattapong; Kaschani, Farnusch; Huang, Jie; Mooney, Brian C.; Li, Yuge; Lyu, Joy; Sueldo, Daniela; Kaiser, Markus; van der Hoorn, Renier A. L.
    Subtilase SBT5.2 inactivates flagellin immunogenicity in the plant apoplast
    In: Nature Communications Vol. 15 (2024) Nr. 1, 10431
  • Podlesainski, David; Adeniyi, Emmanuel T.; Gröner, Yvonne; Schulz, Florian; Krisilia, Violetta; Rehberg, Nidja; Richter, Tim; Sehr, Daria; Xie, Huzhuyue; Simons, Viktor E.; Kiffe-Delf, Anna-Lene; Kaschani, Farnusch; Ioerger, Thomas R.; Kaiser, Markus; Kals et al.
    The anti-tubercular callyaerins target the Mycobacterium tuberculosis-specific non-essential membrane protein Rv2113
    In: Cell Chemical Biology Vol. 31 (2024) Nr. 10, pp. 1755 - 1771.e73
  • Zheng, Kaijie; Lyu, Joy C.; Thomas, Emma L.; Schuster, Mariana; Sanguankiattichai, Nattapong; Ninck, Sabrina; Kaschani, Farnusch; Kaiser, Markus; van der Hoorn, Renier A. L.
    The proteome of Nicotiana benthamiana is shaped by extensive protein processing
    In: New Phytologist Vol. 243 (2024) Nr. 3, pp. 1034 - 1049
  • Day, Matthew; Tetik, Bilal; Parlak, Milena; Almeida-Hernández, Yasser; Räschle, Markus; Kaschani, Farnusch; Siegert, Heike; Marko, Anika; Sanchez-Garcia, Elsa; Kaiser, Markus; Barker, Isabel A.; Pearl, Laurence H.; Oliver, Antony W.; Boos, Dominik.
    TopBP1 utilises a bipartite GINS binding mode to support genome replication
    In: Nature Communications Vol. 15 (2024) Nr. 1, 1797
  • Ninck, Sabrina; Halder, Vivek; Krahn, Jan; Beisser, Daniela; Resch, Sarah; Dodds, Isobel; Scholtysik, René; Bormann, Jenny; Sewald, Leonard; Gupta, Mainak D.; Heilmann, Geronimo; Bhandari, Deepak D.; Morimoto, Kyoko; Buscaill, Pierre; Hause, Bettina; van d et al.
    Chemoproteomics Reveals the Pan-HER Kinase Inhibitor Neratinib To Target an Arabidopsis Epoxide Hydrolase Related to Phytohormone Signaling
    In: ACS Chemical Biology Vol. 18 (2023) Nr. 5, pp. 1076 - 1088
  • Hoi, David M.; Junker, Sabryna; Junk, Lukas; Schwechel, Kristin; Fischel, Katharina; Podlesainski, David; Hawkins, Paige M.E.; van Geelen, Lasse; Kaschani, Farnusch; Leodolter, Julia; Morreale, Francesca Ester; Kleine, Stefan; Guha, Somraj; Rumpel, Klaus; et al.
    Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival
    In: Cell Vol. 186 (2023) Nr. 10, pp. 2176 - 2192.e22
  • Andlovic, Blaž; Heilmann, Geronimo; Ninck, Sabrina; Andrei, Sebastian A.; Centorrino, Federica; Higuchi, Yusuke; Kato, Nobuo; Brunsveld, Luc; Arkin, Michelle; Menninger, Sascha; Choidas, Axel; Wolf, Alexander; Klebl, Bert; Kaschani, Farnusch; Kaiser, Marku et al.
    IFNα primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization
    In: Cell Chemical Biology Vol. 30 (2023) Nr. 6, pp. 573 - 590.e6
  • Rüttermann, Maximilian; Koci, Michelle; Lill, Pascal; Geladas, Ermis Dionysios; Kaschani, Farnusch; Klink, Björn Udo; Erdmann, Ralf; Gatsogiannis, Christos.
    Structure of the peroxisomal Pex1/Pex6 ATPase complex bound to a substrate
    In: Nature Communications Vol. 14 (2023) Nr. 1, 5942
  • Oelschläger, Lisa; Stahl, Paul; Kaschani, Farnusch; Stauber, Roland H.; Knauer, Shirley K.; Hensel, Astrid.
    Taspase1 facilitates Topoisomerase IIβ-mediated DNA double-strand breaks driving estrogen-induced transcription
    In: Cells Vol. 2023 (2023) Nr. 12, 363
  • Blüggel, Mike; Kröning, Alexander; Kracht, Matthias; van den Boom, Johannes; Dabisch, Matthias; Göhring, Anna; Kaschani, Farnusch; Kaiser, Markus; Bayer, Peter; Meyer, Hemmo; Beuck, Christine.
    The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPase
    In: Nature Communications Vol. 14 (2023) Nr. 1, 3258
  • Kiselev, Andrei; Camborde, Laurent; Carballo, Laura Ossorio; Kaschani, Farnusch; Kaiser, Markus; van der Hoorn, Renier A. L.; Gaulin, Elodie.
    The root pathogen Aphanomyces euteiches secretes modular proteases in pea apoplast during host infection
    In: Frontiers in Plant Science (FPLS) Vol. 14 (2023) 1140101
  • Klaus, Thomas; Ninck, Sabrina; Albersmeier, Andreas; Busche, Tobias; Wibberg, Daniel; Jiang, Jianbing; Elcheninov, Alexander G.; Zayulina, Kseniya S.; Kaschani, Farnusch; Bräsen, Christopher; Overkleeft, Herman S.; Kalinowski, Jörn; Kublanov, Ilya V.; Kais et al.
    Activity-Based Protein Profiling for the Identification of Novel Carbohydrate-Active Enzymes Involved in Xylan Degradation in the Hyperthermophilic Euryarchaeon Thermococcus sp. Strain 2319x1E
    In: Frontiers in Microbiology Vol. 12 (2022) 734039
  • Schmerling, Christian; Sewald, Leonard; Heilmann, Geronimo; Witfeld, Frederick; Begerow, Dominik; Jensen, Kenneth; Bräsen, Christopher; Kaschani, Farnusch; Overkleeft, Herman S.; Siebers, Bettina; Kaiser, Markus.
    Erratum: Author Correction: Identification of fungal lignocellulose-degrading biocatalysts secreted by Phanerochaete chrysosporium via activity-based protein profiling (Communications biology (2022) 5 1 (1254))
    In: Communications Biology Vol. 5 (2022) Nr. 1, pp. 1319
  • Schmerling, Christian; Sewald, Leonard; Heilmann, Geronimo; Witfeld, Frederick; Begerow, Dominik; Jensen, Kenneth; Bräsen, Christopher; Kaschani, Farnusch; Overkleeft, Herman S.; Siebers, Bettina; Kaiser, Markus.
    Identification of fungal lignocellulose-degrading biocatalysts secreted by Phanerochaete chrysosporium via activity-based protein profiling
    In: Communications Biology Vol. 5 (2022) Nr. 1, 1254
  • Chauvistré, Heike; Shannan, Batool; Daignault-Mill, Sheena M.; Ju, Robert J.; Picard, Daniel; Egetemaier, Stefanie; Váraljai, Renáta; Gibhardt, Christine S.; Sechi, Antonio; Kaschani, Farnusch; Keminer, Oliver; Stehbens, Samantha J.; Liu, Qin; Yin, Xiangfa et al.
    Persister state-directed transitioning and vulnerability in melanoma
    32. Deutscher Hautkrebskongress (ADO-Jahrestagung), 14.–17. September 2022, Hannover, Germany,
    In: Nature Communications Vol. 13 (2022) Nr. 1, pp. 35 - 36
  • Abreha, Kibrom B.; Alexandersson, Erik; Resjö, Svante; Lankinen, Åsa; Sueldo, Daniela; Kaschani, Farnusch; Kaiser, Markus; van der Hoorn, Renier A. L.; Levander, Fredrik; Andreasson, Erik.
    Article leaf apoplast of field-grown potato analyzed by quantitative proteomics and activity-based protein profiling
    In: International Journal of Molecular Sciences (IJMS) Vol. 22 (2021) Nr. 21, 12033
  • van Geelen, Lasse; Kaschani, Farnusch; Sazzadeh, Shabnam S.; Adeniyi, Emmanuel T.; Meier, Dieter; Proksch, Peter; Pfeffer, Klaus; Kaiser, Markus; Ioerger, Thomas R.; Kalscheuer, Rainer.
    Correction to : Natural brominated phenoxyphenols kill persistent and biofilm-incorporated cells of MRSA and other pathogenic bacteria
    In: Applied Microbiology and Biotechnology Vol. 105 (2021) Nr. 14-15, pp. 6119 - 6119
  • Dorsch, Madeleine; Kowalczyk, Manuela; Planque, Mélanie; Heilmann, Geronimo; Urban, Sebastian; Dujardin, Philip; Forster, Jan; Ueffing, Kristina; Nothdurft, Silke; Oeck, Sebastian; Paul, Annika; Liffers, Sven T.; Kaschani, Farnusch; Kaiser, Markus; Schramm et al.
    Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis
    In: Cell Reports Vol. 37 (2021) Nr. 8, 110056
  • van den Boom, Johannes; Kück, Anja; Kravic, Bojana; Müschenborn, Helen; Giesing, Maike; Pan, Dongqing; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Meyer, Hemmo.
    Targeted substrate loop insertion by VCP/p97 during PP1 complex disassembly
    In: Nature Structural & Molecular Biology Vol. 28 (2021) Nr. 12, pp. 964 - 971
  • van der Woude, Lennard; Piotrowski, Markus; Klaasse, Gruson; Paulus, Judith K.; Krahn, Daniel; Ninck, Sabrina; Kaschani, Farnusch; Kaiser, Markus; Novák, Ondřej; Ljung, Karin; Bulder, Suzanne; van Verk, Marcel; Snoek, Basten L.; Fiers, Martijn; Martin, Nat et al.
    The chemical compound ‘Heatin’ stimulates hypocotyl elongation and interferes with the Arabidopsis NIT1-subfamily of nitrilases
    In: The Plant Journal Vol. 106 (2021) Nr. 6, pp. 1523 - 1540
  • Smolin, Daniel; Tötsch, Niklas; Grad, Jean-Noël; Linders, Jürgen; Kaschani, Farnusch; Kaiser, Markus; Kirsch, Michael; Hoffmann, Daniel; Schrader, Thomas.
    Accelerated trypsin autolysis by affinity polymer templates
    In: RSC Advances Vol. 10 (2020) Nr. 48, pp. 28711 - 28719
  • Smolin, Daniel; Tötsch, Niklas; Grad, Jean-Noël; Linders, Jürgen; Kaschani, Farnusch; Kaiser, Markus; Kirsch, Michael; Hoffmann, Daniel; Schrader, Thomas.
    Accelerated trypsin autolysis by affinity polymer templates
    In: RSC Advances Vol. 10 (2020) Nr. 48, pp. 28711 - 28719
  • Bach-Pages, Marcel; Homma, Felix; Kourelis, Jiorgos; Kaschani, Farnusch; Mohammed, Shabaz; Kaiser, Markus; van der Hoorn, Renier A. L.; Castello, Alfredo; Preston, Gail M.
    Discovering the RNA-binding proteome of plant leaves with an improved RNA interactome capture method
    In: Biomolecules Vol. 10 (2020) Nr. 4, 661
  • van Geelen, Lasse; Kaschani, Farnusch; Sazzadeh, Shabnam S.; Adeniyi, Emmanuel T.; Meier, Dieter; Proksch, Peter; Pfeffer, Klaus; Kaiser, Markus; Ioerger, Thomas R.; Kalscheuer, Rainer.
    Natural brominated phenoxyphenols kill persistent and biofilm-incorporated cells of MRSA and other pathogenic bacteria
    In: Applied Microbiology and Biotechnology Vol. 104 (2020) Nr. 13, pp. 5985 - 5998
  • Kracht, Matthias; van den Boom, Johannes; Seiler, Jonas; Kröning, Alexander; Kaschani, Farnusch; Kaiser, Markus; Meyer, Hemmo.
    Protein Phosphatase-1 Complex Disassembly by p97 is Initiated through Multivalent Recognition of Catalytic and Regulatory Subunits by the p97 SEP-domain Adapters
    In: Journal of Molecular Biology (JMB) Vol. 432 (2020) Nr. 23, pp. 6061 - 6074
  • Göhring, Anna; Michin, Irina; Gerdes, Tina; Schulze, Nina; Blüggel, Mike; Rehic, Edisa; Kaschani, Farnusch; Kaiser, Markus; Bayer, Peter.
    Targeting of parvulin interactors by diazirine mediated cross-linking discloses a cellular role of human Par14/17 in actin polymerization
    In: Biological Chemistry Vol. 401 (2020) Nr. 8, pp. 955 - 968
  • Azizan, Asma; Kaschani, Farnusch; Barinas, Hellen; Blaskowski, Svenja; Kaiser, Markus; Denecke, Martin.
    Using proteomics for an insight into the performance of activated sludge in a lab-scale WWTP
    In: International Biodeterioration & Biodegradation Vol. 149 (2020) pp. 104934
  • Krahn, Daniel; Heilmann, Geronimo; Vogel, Felix C. E.; Papadopoulos, Chrisovalantis; Zweerink, Susanne; Kaschani, Farnusch; Meyer, Hemmo; Rösch, Alexander; Kaiser, Markus.
    Zelkovamycin is an OXPHOS Inhibitory Member of the Argyrin Natural Product Family
    In: Chemistry - A European Journal Vol. 26 (2020) Nr. 39, pp. 8524 - 8531
  • Kourelis, Jiorgos; Kaschani, Farnusch; Grosse-Holz, Friederike M.; Homma, Felix; Kaiser, Markus; van der Hoorn, Renier A. L.
    A homology-guided, genome-based proteome for improved proteomics in the alloploid Nicotiana benthamiana
    In: BMC Genomics Vol. 20 (2019) Nr. 1, pp. 722
  • Jutras, Philippe V.; Grosse-Holz, Friederike; Kaschani, Farnusch; Kaiser, Markus; Michaud, Dominique; Hoorn, Renier A. L. van der.
    Activity-based proteomics reveals nine target proteases for the recombinant protein-stabilizing inhibitor S/CYS8 in Nicotiana benthamiana
    In: Plant Biotechnology Journal Vol. 17 (2019) Nr. 8, pp. 1670 - 1678
  • Weiss-Sadan, Tommy; Itzhak, Gal; Kaschani, Farnusch; Yu, Zhanru; Mahameed, Mohamed; Anaki, Adi; Ben-Nun, Yael; Merquiol, Emmanuelle; Tirosh, Boaz; Kessler, Benedikt; Kaiser, Markus; Blum, Galia.
    Cathepsin L regulates metabolic networks controlling rapid cell growth and proliferation
    In: Molecular and Cellular Proteomics (MCP) Vol. 18 (2019) Nr. 7, pp. 1330 - 1344
  • Weiss-Sadan, Tommy; Maimoun, David; Oelschlagel, Diana; Kaschani, Farnusch; Misiak, Danny; Gaikwad, Hanmant; Ben-Nun, Yael; Merquiol, Emmanuelle; Anaki, Adi; Tsvirkun, Darya; Kaiser, Markus; Michl, Patrick; Gotsman, Israel; Blum, Galia.
    Cathepsins Drive Anti-Inflammatory Activity by Regulating Autophagy and Mitochondrial Dynamics in Macrophage Foam Cells
    In: Cellular Physiology and Biochemistry Vol. 53 (2019) Nr. 3, pp. 550 - 572
  • Viñegra de la Torre, Natanael; Kaschani, Farnusch; Kaiser, Markus; van der Hoorn, Renier A L; Soppe, Wim J J; Misas Villamil, Johana C.
    Dynamic hydrolase labelling as a marker for seed quality in Arabidopsis seeds
    In: Biochemical Journal Vol. 476 (2019) Nr. 5, pp. 843 - 857
  • Buscaill, Pierre; Chandrasekar, Balakumaran; Sanguankiattichai, Nattapong; Kourelis, Jiorgos; Kaschani, Farnusch; Thomas, Emma L.; Morimoto, Kyoko; Kaiser, Markus; Preston, Gail M.; Ichinose, Yuki; Van Der Hoorn, Renier A.L.
    Glycosidase and glycan polymorphism control hydrolytic release of immunogenic flagellin peptides
    In: Science Vol. 364 (2019) Nr. 6436, eaav0748
  • Kraiselburd, Ivana; Brüls, Thomas; Heilmann, Geronimo; Kaschani, Farnusch; Kaiser, Markus; Meckenstock, Rainer.
    Metabolic reconstruction of the genome of candidate Desulfatiglans TRIP_1 and identification of key candidate enzymes for anaerobic phenanthrene degradation
    In: Environmental Microbiology Vol. 21 (2019) Nr. 4, pp. 1267 - 1286
  • Halder, Vivek; Suliman, Mohamed N S; Kaschani, Farnusch; Kaiser, Markus.
    Plant chemical genetics reveals colistin sulphate as a SA and NPR1-independent PR1 inducer functioning via a p38-like kinase pathway
    In: Scientific Reports Vol. 9 (2019) Nr. 1, pp. 11196
  • Schulze Hüynck, Jan; Kaschani, Farnusch; van der Linde, Karina; Ziemann, Sebastian; Müller, André N.; Colby, Thomas; Kaiser, Markus; Misas Villamil, Johana C.; Doehlemann, Gunther.
    Proteases underground : Analysis of the maize root apoplast identifies organ specific papain-like cysteine protease activity
    In: Frontiers in Plant Science (FPLS) Vol. 10 (2019)
  • Morimoto, Kyoko; Cole, Kyle S.; Kourelis, Jiorgos; Witt, Collin H.; Brown, Daniel; Krahn, Daniel; Stegmann, Monika; Kaschani, Farnusch; Kaiser, Markus; Burton, Jonathan; Mohammed, Shabaz; Yamaguchi-Shinozaki, Kazuko; Weerapana, Eranthie; van der Hoorn, Ren et al.
    Triazine probes target ascorbate peroxidases in plants
    In: Plant Physiology Vol. 180 (2019) Nr. 4, pp. 1848 - 1859
  • Pöhler, Robert; Krahn, Jan; van den Boom, Johannes; Dobrynin, Grzegorz; Kaschani, Farnusch; Eggenweiler, Hans-Michael; Zenke, Frank T.; Kaiser, Markus; Meyer, Hemmo.
    A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases
    In: Angewandte Chemie International Edition Vol. 57 (2018) Nr. 6, pp. 1576 - 1580
  • Ziemann, Sebastian; Van Der Linde, Karina; Lahrmann, Urs; Acar, Beyda; Kaschani, Farnusch; Colby, Tom; Kaiser, Markus; Ding, Yezhang; Schmelz, Eric; Huffaker, Alisa; Holton, Nicholas; Zipfel, Cyril; Doehlemann, Gunther.
    An apoplastic peptide activates salicylic acid signalling in maize
    In: Nature Plants Vol. 4 (2018) Nr. 3, pp. 172 - 180
  • Dong, Xiyang; Greening, Chris; Brüls, Thomas; Conrad, Ralf; Guo, Kun; Blaskowski, Svenja; Kaschani, Farnusch; Kaiser, Markus; Abu Laban, Nidal; Meckenstock, Rainer.
    Fermentative Spirochaetes mediate necromass recycling in anoxic hydrocarbon-contaminated habitats
    In: ISME Journal Vol. 12 (2018) Nr. 8, pp. 2039 - 2050
  • Schillinger, Jasmin; Severin, Katharina; Kaschani, Farnusch; Kaiser, Markus; Ehrmann, Michael.
    HTRA1-Dependent Cell Cycle Proteomics
    In: Journal of Proteome Research Vol. 17 (2018) Nr. 8, pp. 2679 - 2694
  • Bongard, Jens; Lorenz, Marian; Vetter, Ingrid R.; Stege, Patricia; Porfetye, Arthur T.; Schmitz, Anna Laura; Kaschani, Farnusch; Wolf, Alex; Koch, Uwe; Nussbaumer, Peter; Klebl, Bert; Kaiser, Markus; Ehrmann, Michael.
    Identification of Noncatalytic Lysine Residues from Allosteric Circuits via Covalent Probes
    In: ACS Chemical Biology Vol. 13 (2018) Nr. 5, pp. 1307 - 1312
  • Halder, Vivek; Oeljeklaus, Julian; Heilmann, Geronimo; Krahn, Jan; Liu, Yanlin; Xiong, Yan; Schlicht, Markus; Schillinger, Jasmin; Kracher, Barbara; Ehrmann, Michael; Kombrink, Erich; Kaschani, Farnusch; Kaiser, Markus.
    Identification of the Natural Product RotihibinA as a TOR Kinase Signaling Inhibitor by Unbiased Transcriptional Profiling
    In: Chemistry - A European Journal Vol. 24 (2018) Nr. 48, pp. 12500 - 12504
  • Santos, Rita B.; Chandrasekar, Balakumaran; Mandal, Manoj K.; Kaschani, Farnusch; Kaiser, Markus; Both, Leonard; van der Hoorn, Renier A. L.; Schiermeyer, Andreas; Abranches, Rita.
    Low Protease Content in Medicago truncatula Cell Cultures Facilitates Recombinant Protein Production
    In: Biotechnology Journal Vol. 13 (2018) Nr. 7, 1800050
  • Husaini, Amjad M; Morimoto, Kyoko; Chandrasekar, Balakumaran; Kelly, Steven; Kaschani, Farnusch; Palmero, Daniel; Jiang, Jianbing; Kaiser, Markus; Ahrazem, Oussama; Overkleeft, Hermen S; van der Hoorn, Renier A L.
    Multiplex Fluorescent, Activity-Based Protein Profiling Identifies Active α-Glycosidases and Other Hydrolases in Plants
    In: Plant Physiology Vol. 177 (2018) Nr. 1, pp. 24 - 37
  • Planas-Marquès, Marc; Bernardo-Faura, Martí; Paulus, Judith; Kaschani, Farnusch; Kaiser, Markus; Valls, Marc; Van Der Hoorn, Renier A. L.; Coll, Núria S.
    Protease Activities Triggered by Ralstonia solanacearum Infection in Susceptible and Tolerant Tomato Lines
    In: Molecular and Cellular Proteomics (MCP) Vol. 17 (2018) Nr. 6, pp. 1112 - 1125
  • Grosse-Holz, Friederike; Kelly, Steven; Blaskowski, Svenja; Kaschani, Farnusch; Kaiser, Markus; van der Hoorn, Renier A.L.
    The transcriptome, extracellular proteome and active secretome of agroinfiltrated Nicotiana benthamiana uncover a large, diverse protease repertoire
    In: Plant Biotechnology Journal Vol. 16 (2018) Nr. 5, pp. 1068 - 1084
  • Grosse-Holz, Friederike; Madeira, Luisa; Zahid, Muhammad Awais; Songer, Molly; Kourelis, Jiorgos; Fesenko, Mary; Ninck, Sabrina; Kaschani, Farnusch; Kaiser, Markus; van der Hoorn, Renier A.L.
    Three unrelated protease inhibitors enhance accumulation of pharmaceutical recombinant proteins in Nicotiana benthamiana
    In: Plant Biotechnology Journal Vol. 16 (2018) Nr. 10, pp. 1797 - 1810
  • Weith, Matthias; Seiler, Jonas; van den Boom, Johannes; Kracht, Matthias; Hülsmann, Julia; Primorac, Ivana; Del Pino Garcia, Javier; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Bollen, Mathieu; Meyer, Hemmo.
    Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation
    In: Molecular Cell Vol. 72 (2018) Nr. 4, pp. 766 - 777
  • Bravo-Rodriguez, Kenny; Hagemeier, Birte; Drescher, Lea; Lorenz, Marian; Rey, Juliana; Meltzer, Michael; Kaschani, Farnusch; Kaiser, Markus; Ehrmann, Michael.
    Utilities for Mass Spectrometry Analysis of Proteins (UMSAP) : Fast post-processing of mass spectrometry data
    In: Rapid Communications in Mass Spectrometry Vol. 32 (2018) Nr. 19, pp. 1659 - 1667
  • Zweerink, Susanne; Kallnik, Verena; Ninck, Sabrina; Nickel, Sabrina; Verheyen, Julia; Blum, Marcel; Wagner, Alexander; Feldmann, Ingo; Sickmann, Albert; Albers, Sonja-Verena; Bräsen, Christopher; Kaschani, Farnusch; Siebers, Bettina; Kaiser, Markus.
    Activity-based protein profiling as a robust method for enzyme identification and screening in extremophilic Archaea
    In: Nature Communications Vol. 8 (2017) pp. 15352
  • Klein, Diana; Steens, Jennifer; Wiesemann, Alina; Schulz, Florian; Kaschani, Farnusch; Röck, Katharina; Yamaguchi, Masahiro; Wirsdörfer, Florian; Kaiser, Markus; Fischer, Jens W.; Stuschke, Martin; Jendrossek, Verena.
    Mesenchymal stem cell therapy protects lungs from radiation-induced endothelial cell loss by restoring superoxide dismutase 1 expression
    In: Antioxidants and Redox Signaling Vol. 26 (2017) Nr. 11, pp. 563 - 582
  • Kovács, Judit; Poór, Péter; Kaschani, Farnusch; Chandrasekar, Balakumaran; Hong, Tram N.; Misas-Villamil, Johana C.; Xin, Bo T.; Kaiser, Markus; Overkleeft, Herman S.; Tari, Irma; van der Hoorn, Renier A. L.
    Proteasome activity profiling uncovers alteration of catalytic β2 and β5 subunits of the stress-induced proteasome during salinity stress in tomato roots
    In: Frontiers in Plant Science (FPLS) Vol. 8 (2017) 107
  • Beisser, Daniela; Kaschani, Farnusch; Graupner, Nadine; Großmann, Lars; Jensen, Manfred; Ninck, Sabrina; Schulz, Florian; Rahmann, Sven; Boenigk, Jens; Kaiser, Markus.
    Quantitative proteomics reveals ecophysiological effects of light and silver stress on the mixotrophic protist Poterioochromonas malhamensis
    In: PLoS ONE Vol. 12 (2017) Nr. 1, pp. e0168183
  • Misas-Villamil, Johana C.; van der Burgh, Aranka M.; Grosse-Holz, Friederike; Bach-Pages, Marcel; Kovács, Judit; Kaschani, Farnusch; Schilasky, Sören; Emon, Asif E.K.; Ruben, Mark; Kaiser, Markus; Overkleeft, Hermen S.; van der Hoorn, Renier A.L.
    Subunit-selective proteasome activity profiling uncovers uncoupled proteasome subunit activities during bacterial infections
    In: The Plant Journal Vol. 90 (2017) Nr. 2, pp. 418 - 430
  • De Montaigu, Amaury; Oeljeklaus, Julian; Krahn, Jan; Suliman, Mohamed N.S.; Halder, Vivek; De Ansorena, Elisa; Nickel, Sabrina; Schlicht, Markus; Plíhal, Ondřej; Kubiasová, Karolina; Radová, Lenka; Kracher, Barbara; Tóth, Réka; Kaschani, Farnusch; Coupland et al.
    The Root Growth-Regulating Brevicompanine Natural Products Modulate the Plant Circadian Clock
    In: ACS Chemical Biology Vol. 12 (2017) Nr. 6, pp. 1466 - 1471
  • Krahn, Jan; Kaschani, Farnusch; Kaiser, Markus.
    Turning-ON Proteasomes
    In: Cell Chemical Biology Vol. 24 (2017) Nr. 6, pp. 653 - 655
  • Shaulov-Rotem, Yulia; Merquiol, Emmanuelle; Weiss-Sadan, Tommy; Moshel, Ofra; Salpeter, Seth; Shabat, Doron; Kaschani, Farnusch; Kaiser, Markus; Blum, Galia.
    A novel quenched fluorescent activity-based probe reveals caspase-3 activity in the endoplasmic reticulum during apoptosis
    In: Chemical Science Vol. 7 (2016) pp. 1322 - 1337
  • Kaschani, Farnusch; Wei, Quing; Dingemans, Jozef; van der Hoorn, Renier A.L.; Cornelis, Pierre; Kaiser, Markus.
    Capture of endogenously biotinylated proteins from Pseudomonas aeruginosa displays unexpected downregulation of LiuD upon iron nutrition
    In: Bioorganic and Medicinal Chemistry Vol. 24 (2016) Nr. 15, pp. 3330 - 3335
  • Shindo, Takayuki; Kaschani, Farnusch; Yang, Fan; Kovács, Judit; Tian, Fang; Kourelis, Jiorgos; Hong, Tram Ngoc; Colby, Tom; Shabab, Mohammed; Chawla, Rohini; Kumari, Selva; Ilyas, Muhammad; Hörger, Anja C.; Alfano, James R.; van der Hoorn, Renier A. L.
    Screen of Non-annotated Small Secreted Proteins of Pseudomonas syringae Reveals a Virulence Factor That Inhibits Tomato Immune Proteases
    In: PLoS Pathogens Vol. 12 (2016) Nr. 9, pp. 1005874
  • van den Boom, Johannes; Wolf, Markus; Weimann, Lena; Schulze, Nina; Li, Fanghua; Kaschani, Farnusch; Riemer, Anne; Zierhut, Christian; Kaiser, Markus; Iliakis, George; Funabiki, Hironori; Meyer, Hemmo.
    VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair
    In: Molecular Cell Vol. 64 (2016) Nr. 1, pp. 189 - 198
  • Ehrmann, Michael; Kaschani, Farnusch; Kaiser, Markus.
    Chemical proteomics versus Leishmaniasis
    In: Chemistry and Biology Vol. 22 (2015) Nr. 3, pp. 309 - 310
  • Nickel, Sabrina; Serwa, Remigiusz A.; Kaschani, Farnusch; Ninck, Sabrina; Zweerink, Susanne; Tate, Edward W.; Kaiser, Markus.
    Chemoproteomic Evaluation of the Polyacetylene Callyspongynic Acid
    In: Chemistry - A European Journal Vol. 21 (2015) Nr. 30, pp. 10721 - 10728
  • Poepsel, Simon; Sprengel, Andreas; Sacca, Barbara; Kaschani, Farnusch; Kaiser, Markus; Gatsogiannis, Christos; Raunser, Stefan; Clausen, Tim; Ehrmann, Michael.
    Determinants of amyloid fibril degradation by the PDZ protease HTRA1
    In: Nature Chemical Biology Vol. 11 (2015) Nr. 11, pp. 862 - 869
  • Ilyas, Muhammad; Hörger, Anja C.; Bozkurt, Tolga O.; Burg, Harrold A. van den; Kaschani, Farnusch; Kaiser, Markus; Belhaj, Khaoula; Smoker, Matthew; Joosten, Matthieu H. A. J.; Kamoun, Sophien; Hoorn, Renier A. L. van der.
    Functional divergence of two secreted immune proteases of tomato
    In: Current Biology Vol. 25 (2015) Nr. 17, pp. 2300 - 2306