ZMB Member Carsten Kirschning

ZMB Member
Carsten Kirschning

Next ZMB-Member
portrait picture Carsten Kirschning
© Kirschning

Prof. Dr. Carsten Kirschning

Group

Regulation of Pathogen-specific Immunity

Institute of Medical Microbiology
University Hospital Essen
Hufelandstr. 55
45147 Essen

Research Overview

Our group investigates cellular pattern recognition and its effects both on the molecular level with regard to both specific ligand - receptor interactions and intracellular signal transduction, as well as on the cellular and systemic level for infections and sterile interruptions of normal homeostasis due to trauma. Our main goal is to make a substantial contribution to the elucidation of the mode of action of pattern recognition receptors (PRR) using molecular biological, protein biochemical and immunological methods.
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Selected Publications

    Journal articles

  • Dyckhoff-Shen, Susanne; Masouris, Ilias; Islam, Heba; Hammerschmidt, Sven; Angele, Barbara; Marathe, Veena; Buer, Jan; Völk, Stefanie; Pfister, Hans-Walter; Klein, Matthias; Koedel, Uwe; Kirschning, Carsten J.
    Combining antibiotic with anti-TLR2/ TLR13 therapy prevents brain pathology in pneumococcal meningitis
    In: JCI Insight Vol. 9 (2024) Nr. 6, e165737
    Online Full Text: dx.doi.org/ (Open Access)
  • Madel, Rabea J.; Börger, Verena; Dittrich, Robin; Bremer, Michel; Tertel, Tobias; Phuong, Nhi Ngo Thi; Baba, Hideo Andreas; Kordelas, Lambros; Staubach, Simon; Stein, Frank; Haberkant, Per; Hackl, Matthias; Grillari, Regina; Grillari, Johannes; Buer, Jan; Horn, Peter; Westendorf, Astrid; Brandau, Sven; Kirschning, Carsten Jürgen; Giebel, Bernd
    Independent human mesenchymal stromal cell–derived extracellular vesicle preparations differentially attenuate symptoms in an advanced murine graft-versus-host disease model
    In: Cytotherapy (2023)
    Online Full Text: dx.doi.org/ (Open Access)
  • Buys, Willem; Bick, Alexandra; Madel, Rabea J.; Westendorf, Astrid; Buer, Jan; Herbstreit, Frank; Kirschning, Carsten Jürgen; Peters, Jürgen
    Substantial heterogeneity of inflammatory cytokine production and its inhibition by a triple cocktail of toll-like receptor blockers in early sepsis
    In: Frontiers in Immunology Vol. 14 (2023) 1277033
    Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Wyczanska, Maja; Rohling, Jana; Keller, Ursula; Benz, Marcus R.; Kirschning, Carsten; Lange-Sperandio, Bärbel
    TLR2 mediates renal apoptosis in neonatal mice subjected experimentally to obstructive nephropathy
    In: PLoS ONE Vol. 18 (2023) Nr. 11, e0294142
    Online Full Text: dx.doi.org/ (Open Access)
  • Wilk, Camilla; Effenberg, Laura; Abberger, Hanna; Steenpass, Laura; Hansen, Wiebke; Zeschnigk, Michael; Kirschning, Carsten Jürgen; Buer, Jan; Kehrmann, Jan
    CRISPR/Cas9-mediated demethylation of FOXP3-TSDR toward Treg-characteristic programming of Jurkat T cells
    In: Cellular Immunology Vol. 371 (2022) 104471
    Online Full Text: dx.doi.org/
  • Meng, Guangxun; Kirschning, Carsten Jürgen; Zhou, Rongbin
    Editorial: Patho- and Physiological Roles of Inflammasomes
    In: Frontiers in Immunology Vol. 13 (2022) 857929
    Online Full Text: dx.doi.org/ (Open Access)
  • Bick, Alexandra; Buys, Willem; Engler, Andrea; Madel, Rabea; Atia, Mazen; Faro, Francesca; Westendorf, Astrid; Limmer, Andreas; Buer, Jan; Herbstreit, Frank; Kirschning, Carsten Jürgen; Peters, Jürgen
    Immune hyporeactivity to bacteria and multiple TLR-ligands, yet no response to checkpoint inhibition in patients just after meeting Sepsis-3 criteria
    In: PLoS ONE Vol. 17 (2022) Nr. 8, e0273247
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Yang, Xiaoli; Ali, Shafaqat; Zhao, Manman; Richter, Lisa; Schäfer, Vanessa; Schliehe-Diecks, Julian; Frank, Marian; Qi, Jing; Larsen, Pia-Katharina; Skerra, Jennifer; Islam, Heba; Wachtmeister, Thorsten; Alter, Christina; Huang, Anfei; Bhatia, Sanil; Köhrer, Karl; Kirschning, Carsten Jürgen; Weighardt, Heike; Kalinke, Ulrich; Kalscheuer, Rainer; Uhrberg, Markus; Scheu, Stefanie
    The Mycotoxin Beauvericin Exhibits Immunostimulatory Effects on Dendritic Cells via Activating the TLR4 Signaling Pathway
    In: Frontiers in Immunology Vol. 13 (2022) 856230
    Online Full Text: dx.doi.org/ (Open Access)
  • Teske, Nina C.; Engelen-Lee, Joo-Yeon; Dyckhoff-Shen, Susanne; Pfister, Hans-Walter; Klein, Matthias; van de Beek, Diederik; Kirschning, Carsten Jürgen; Koedel, Uwe; Brouwer, Matthijs C.
    The role of plasminogen activator inhibitor-2 in pneumococcal meningitis
    In: Acta Neuropathologica Communications Vol. 10 (2022) Nr. 1, 155
    Online Full Text: dx.doi.org/ (Open Access)
  • Li, Qian; Wang, Jun; Islam, Heba; Kirschning, Carsten Jürgen; Lu, Hongzhou; Hoffmann, Daniel; Dittmer, Ulf; Lu, Mengji
    Hepatitis B virus particles activate B cells through the TLR2–MyD88–mTOR axis
    In: Cell Death and Disease Vol. 12 (2021) Nr. 1, 34
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Kibler, Artur; Budeus, Bettina; Homp, Ekaterina; Bronischewski, Kevin; Berg, Victoria; Sellmann, Ludger; Murke, Florian; Heinold, Andreas; Heinemann, Falko M.; Lindemann, Monika; Bekeredjian-Ding, Isabelle; Horn, Peter; Kirschning, Carsten Jürgen; Küppers, Ralf; Seifert, Marc
    Systematic memory B cell archiving and random display shape the human splenic marginal zone throughout life
    In: Journal of Experimental Medicine (JEM) Vol. 218 (2021) Nr. 4, pp. e20201952
    Online Full Text: dx.doi.org/ (Open Access)
  • Kleinertz, Holger; Hepner-Schefczyk, Monika; Ehnert, Sabrina; Claus, Maren; Halbgebauer, Rebecca; Boller, Lea; Huber-Lang, Markus; Cinelli, Paolo; Kirschning, Carsten Jürgen; Flohé, Sascha; Sander, André; Waydhas, Christian; Vonderhagen, Sonja; Jäger, Marcus; Dudda, Marcel; Watzl, Carsten; Flohe, Stefanie
    Circulating growth/differentiation factor 15 is associated with human CD56(bright) natural killer cell dysfunction and nosocomial infection in severe systemic inflammation
    In: EBioMedicine Vol. 43 (2019) pp. 380 - 391
    Online Full Text: dx.doi.org/ (Open Access)
  • Heß, Rebecca; Storcksdieck Genannt Bonsmann, Michael; Lapuente, Dennis; Maaske, Andre; Kirschning, Carsten Jürgen; Ruland, Jürgen; Lepenies, Bernd; Hannaman, Drew; Tenbusch, Matthias; Überla, Klaus
    Glycosylation of HIV Env Impacts IgG Subtype Responses to Vaccination
    In: Viruses Vol. 11 (2019) Nr. 2, pp. 153
    Online Full Text: dx.doi.org/ (Open Access)
  • Madel, R.; Borger, V.; Bremer, M.; Horn, Peter; Baba, Hideo Andreas; Brandau, Sven; Buer, Jan; Giebel, Bernd; Kirschning, Carsten Jürgen
    MSC-EVS protect mice from graft-versus-host disease pathology in a preparation dependent manner
    In: Cytotherapy Vol. 21 (2019) Nr. Suppl. 5, pp. 57
    Online Full Text: dx.doi.org/
  • Fleming, Viktor; Hu, Xiaoying; Weller, Céline; Weber, Rebekka; Groth, Christopher; Riester, Zeno; Hüser, Laura; Sun, Qian; Nagibin, Vasyl; Kirschning, Carsten Jürgen; Bronte, Vincenzo; Utikal, Jochen; Altevogt, Peter; Umansky, Viktor
    Melanoma extracellular vesicles generate immunosuppressive myeloid cells by upregulating PD-L1 via TLR4 signaling
    In: Cancer Research Vol. 79 (2019) Nr. 18, pp. 4715 - 4728
    Online Full Text: dx.doi.org/ (Open Access)
  • Zhang, Ejuan; Ma, Zhiyong; Li, Qian; Yan, Hu; Liu, Jia; Wu, Weimin; Guo, Jiabao; Zhang, Xiaoyong; Kirschning, Carsten Jürgen; Xu, Haifeng; Lang, Philipp A.; Yang, Dongliang; Dittmer, Ulf; Yan, Huimin; Lu, Mengji
    TLR2 stimulation increases cellular metabolism in CD8⁺ T cells and thereby enhances CD8⁺ T cell activation, function, and antiviral activity
    In: The Journal of Immunology (JI) Vol. 203 (2019) Nr. 11, pp. 2872 - 2886
    Online Full Text: dx.doi.org/ (Open Access)
  • Li, Qian; Yan, Yan; Liu, Jia; Huang, Xuan; Zhang, Xiaoyong; Kirschning, Carsten Jürgen; Xu, Haifeng C.; Lang, Philipp A.; Dittmer, Ulf; Zhang, Ejuan; Lu, Mengji
    Toll-Like Receptor 7 Activation Enhances CD8+ T Cell Effector Functions by Promoting Cellular Glycolysis
    In: Frontiers in Immunology Vol. 10 (2019) pp. 2191
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Robak, Oliver H.; Heimesaat, Markus M.; Kruglov, Andrey A.; Prepens, Sandra; Ninnemann, Justus; Gutbier, Birgitt; Reppe, Katrin; Hochrein, Hubertus; Suter, Mark; Kirschning, Carsten Jürgen; Marathe, Veena; Buer, Jan; Hornef, Mathias W.; Schnare, Markus; Schneider, Pascal; Witzenrath, Martin; Bereswill, Stefan; Steinhoff, Ulrich; Suttorp, Norbert; Sander, Leif E.; Chaput, Catherine; Opitz, Bastian
    Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia
    In: The Journal of Clinical Investigation (JCI) Vol. 128 (2018) Nr. 8, pp. 3535 - 3545
    Online Full Text: dx.doi.org/ (Open Access)
  • Gharun, Kourosh; Senges, Julia; Seidl, Maximilian; Lösslein, Anne; Kolter, Julia; Lohrmann, Florens; Fliegauf, Manfred; Elgizouli, Magdeldin; Alber, Marco; Vavra, Martina; Schachtrup, Kristina; Illert, Anna L; Gilleron, Martine; Kirschning, Carsten Jürgen; Triantafyllopoulou, Antigoni; Henneke, Philipp
    Corrigendum: Mycobacteria exploit nitric oxide-induced transformation of macrophages into permissive giant cells
    In: EMBO Reports Vol. 19 (2018) Nr. 12, pp. e47190
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Klein, Johanna C.; Moses, Katrin; Zelinskyy, Gennadiy; Sody, Simon; Buer, Jan; Lang, Stephan; Helfrich, Iris; Dittmer, Ulf; Kirschning, Carsten Jürgen; Brandau, Sven
    Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth
    In: Nature Communications Vol. 8 (2017) pp. 14600
    Online Full Text: dx.doi.org/ (Open Access)
  • Krieg, Sandro M; Voigt, Florian; Knuefermann, Pascal; Kirschning, Carsten Jürgen; Plesnila, Nikolaus; Ringel, Florian
    Decreased Secondary Lesion Growth and Attenuated Immune Response after Traumatic Brain Injury in Tlr2/4-/- Mice.
    In: Frontiers in Neurology Vol. 8 (2017) pp. 455
    Online Full Text: dx.doi.org/ (Open Access)
  • Stein, Karina; Brand, Stephanie; Jenckel, André; Sigmund, Anna; Chen, Zhijian James; Kirschning, Carsten Jürgen; Kauth, Marion; Heine, Holger
    Endosomal recognition of Lactococcus lactis G121 and its RNA by dendritic cells is key to its allergy-protective effects
    In: The Journal of Allergy and Clinical Immunology Vol. 139 (2017) Nr. 2, pp. 667 - 678.e5
    Online Full Text: dx.doi.org/
  • Gharun, Kourosh; Senges, Julia; Seidl, Maximilian; Lösslein, Anne; Kolter, Julia; Lohrmann, Florens; Fliegauf, Manfred; Elgizouli, Magdeldin; Vavra, Martina; Schachtrup, Kristina; Illert, Anna L; Gilleron, Martine; Kirschning, Carsten Jürgen; Triantafyllopoulou, Antigoni; Henneke, Philipp
    Mycobacteria exploit nitric oxide-induced transformation of macrophages into permissive giant cells
    In: EMBO Reports Vol. 18 (2017) Nr. 12, pp. 2144 - 2159
    Online Full Text: dx.doi.org/
  • Makkawi, Hasnaa; Hoch, Shifra; Burns, Elia; Hosur, Kavita; Hajishengallis, George; Kirschning, Carsten Jürgen; Nussbaum, Gabriel
    Porphyromonas gingivalis stimulates TLR2-PI3K signaling to escape immune clearance and induce bone resorption independently of MyD88
    In: Frontiers in Cellular and Infection Microbiology Vol. 7 (2017) pp. 359
    Online Full Text: dx.doi.org/ (Open Access)
  • Stein, K.; Jenckel, A.; Brand, S.; Sigmund, A.; Kirschning, Carsten Jürgen; Kauth, M.; Heine, H.
    RNA is the key element of the th1-promoting and allergy-protective activation of dendritic cells by the cowshed bacterium lactococcus lactis G121
    In: Allergy Vol. 72 (2017) Nr. Suppl. 103 SI, S. 93 Abstract 0108
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Ma, Zhiyong; Liu, Jia; Wu, Weimin; Zhang, Ejuan; Zhang, Xiaoyong; Li, Qian; Zelinskyy, Gennadiy; Buer, Jan; Dittmer, Ulf; Kirschning, Carsten Jürgen; Lu, Mengji
    The IL-1R/TLR signaling pathway is essential for efficient CD8+ T-cell responses against hepatitis B virus in the hydrodynamic injection mouse model
    In: Cellular & Molecular Immunology Vol. 14 (2017) Nr. 12, pp. 997 - 1008
    Online Full Text: dx.doi.org/ (Open Access)
  • Schick, Judith; Etschel, Philipp; Bailo, Rebeca; Ott, Lisa; Bhatt, Apoorva; Lepenies, Bernd; Kirschning, Carsten Jürgen; Burkovski, Andreas; Lang, Roland
    Toll-like receptor 2 and Mincle cooperatively sense corynebacterial cell wall glycolipids
    In: Infection and Immunity Vol. 85 (2017) Nr. 7, pp. e00075 - 17
    Online Full Text: dx.doi.org/ (Open Access)
  • Lehmann, Michael H.; Torres-Domínguez, Lino E.; Price, Philip J. R.; Brandmüller, Christine; Kirschning, Carsten Jürgen; Sutter, Gerd
    CCL2 expression is mediated by type I IFN receptor and recruits NK and T cells to the lung during MVA infection
    In: Journal of Leukocyte Biology (JLB) Vol. 99 (2016) Nr. 6, pp. 1057 - 1064
    Online Full Text: dx.doi.org/
  • Maney, Sathish Kumar; Xu, Haifeng C; Huang, Jun; Pandyra, Aleksandra A; Ehlting, Christian; Aguilar-Valenzuela, Renan; Pozdeev, Vitaly I; McIlwain, David R; Zimmermann, Albert; Bode, Johannes G; Hengel, Hartmut; Kirschning, Carsten Jürgen; Kim, Ira R; Hiscott, John; Brenner, Dirk; Häussinger, Dieter; Ohashi, Pamela S; Mak, Tak W; Lang, Karl S.; Lang, Philipp A
    RAIDD Mediates TLR3 and IRF7 Driven Type I Interferon Production
    In: Cellular Physiology and Biochemistry Vol. 39 (2016) Nr. 4, pp. 1271 - 1280
    Online Full Text: dx.doi.org/ (Open Access)
  • Kaesler, Susanne; Biedermann, Tilo; Röcken, Martin; Kirschning, Carsten Jürgen; Hartung, Thomas; Hein, Ulrike; Wölbing, Florian; Köberle, Martin; Volz, Thomas; Kempf, Wolfgang E.; Chen, Ko-Ming; Skabytska, Yuliya
    Staphylococcus aureus–derived lipoteichoic acid induces temporary T-cell paralysis independent of Toll-like receptor 2
    In: The Journal of Allergy and Clinical Immunology Vol. 138 (2016) Nr. 3, pp. 780 - 790.e6
    Online Full Text: dx.doi.org/
  • Kolter, Julia; Kirschning, Carsten Jürgen; Waskow, Claudia; Goldmann, Tobias; Trieu-Cuot, Patrick; Elling, Roland; Gharun, Kourosh; Spoeri, Evelyne; Feuerstein, Reinhild
    Streptococci Engage TLR13 on Myeloid Cells in a Site-Specific Fashion
    In: The Journal of Immunology (JI) Vol. 196 (2016) Nr. 6, pp. 2733 - 2741
    Online Full Text: dx.doi.org/ (Open Access)
  • Castiglia, Virginia; Piersigilli, Alessandra; Ebner, Florian; Janos, Marton; Goldmann, Oliver; Damböck, Ursula; Kröger, Andrea; Weiss, Sigfried; Knapp, Sylvia; Jamieson, Amanda M; Kirschning, Carsten Jürgen; Kalinke, Ulrich; Strobl, Birgit; Müller, Mathias; Stoiber, Dagmar; Lienenklaus, Stefan; Kovarik, Pavel
    Type I Interferon Signaling Prevents IL-1β-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue
    In: Cell Host & Microbe Vol. 19 (2016) Nr. 3, pp. 375 - 387
    Online Full Text: dx.doi.org/ (Open Access)
  • Heine, H.; Stein, K.; Jenckel, A.; Brand, S.; Sigmund, A; Holst, O.; Kirschning, Carsten Jürgen; Kauth, M.
    Allergy-protection by the cowshed bacterium Lactococcus lactis G121 involves endosomal acidification and signaling through TLR13 in dendritic cells
    In: Allergy Vol. 70 (2015) Nr. Suppl. 101, pp. 52 - 53
    Online Full Text: dx.doi.org/ (Open Access)
  • Krüger, Anne; Oldenburg, Marina; Chebrolu, Chiranjeevi; Beisser, Daniela; Kolter, Julia; Sigmund, Anna M.; Steinmann, Jörg; Schäfer, Simon; Hochrein, Hubertus; Rahmann, Sven; Wagner, Hermann; Henneke, Philipp; Hornung, Veit; Buer, Jan; Kirschning, Carsten Jürgen
    Human TLR8 senses UR/URR motifs in bacterial and mitochondrial RNA
    In: EMBO Reports Vol. 16 (2015) Nr. 12, pp. 1656 - 1663
    Online Full Text: dx.doi.org/ (Open Access)
  • Fieber, Christina; Janos, Marton; Koestler, Tina; Gratz, Nina; Li, Xiao-Dong; Castiglia, Virginia; Aberle, Marion; Sauert, Martina; Wegner, Mareike; Alexopoulou, Lena; Kirschning, Carsten Jürgen; Chen, Zhijian J.; Haeseler, Arndt von; Kovarik, Pavel
    Innate immune response to Streptococcus pyogenes depends on the combined activation of TLR13 and TLR2
    In: PLoS ONE Vol. 10 (2015) Nr. 3, pp. e0119727
    Online Full Text: dx.doi.org/ (Open Access)
  • Chebrolu, Chiranjeevi; Artner, Daniel; Sigmund, Anna M; Buer, Jan; Zamyatina, Alla; Kirschning, Carsten Jürgen
    Species and mediator specific TLR4 antagonism in primary human and murine immune cells by βGlcN(1 ↔ 1)αGlc based lipid A mimetics
    In: Molecular Immunology Vol. 67 (2015) Nr. 2 B, pp. 636 - 641
    Online Full Text: dx.doi.org/
  • Price,, Phillip J. R.; Luckow, Bruno; Torres-Domínguez, Lino E.; Brandmüller, Christine; Zorn, Julia; Kirschning, Carsten Jürgen; Sutter, Gerd; Lehmann, Michael H.
    Chemokine (C-C Motif) Receptor 1 Is Required for Efficient Recruitment of Neutrophils during Respiratory Infection with Modified Vaccinia Virus Ankara
    In: Journal of Virology Vol. 88 (2014) Nr. 18, pp. 10840 - 10850
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Dankmeyer, Jennifer L.; Fast, Randy L.; Cote, Christopher K.; Worsham, Patricia L.; Fritz, David; Fisher, Diana; Kern, Steven J.; Merkel, Tod; Kirschning, Carsten Jürgen; Amemiya, Kei
    Multiple roles of Myd88 in the immune response to the plague F1-V vaccine and in protection against an aerosol challenge of Yersinia pestis CO92 in mice
    In: Journal of Immunology Research (2014) pp. 341820
    Online Full Text: dx.doi.org/ (Open Access)
  • Volz, Thomas; Skabytska, Yuliya; Guenova, Emmanuella; Chen, Ko-Ming; Frick, Julia-Stefanie; Kirschning, Carsten Jürgen; Kaesler, Susanne; Röcken, Martin; Biedermann, Tilo
    Nonpathogenic bacteria alleviating atopic dermatitis inflammation induce IL-10-producing dendritic cells and regulatory Tr1 cells
    In: Journal of Investigative Dermatology Vol. 134 (2014) Nr. 1, pp. 96 - 104
    Online Full Text: dx.doi.org/ (Open Access)
  • Knuschke, Torben; Bayer, Wibke; Rotan, Olga; Sokolova, Viktoriya; Wadwa, Munisch; Kirschning, Carsten Jürgen; Hansen, Wiebke; Sparwasser, T.; Dittmer, Ulf; Epple, Matthias; Buer, Jan; Westendorf, Astrid
    Prophylactic and therapeutic vaccination with a nanoparticle-based peptide vaccine induces efficient protective immunity during acute and chronic retroviral infection
    In: Nanomedicine: Nanotechnology, Biology, and Medicine Vol. 10 (2014) Nr. 8, pp. 1787 - 1798
    Online Full Text: dx.doi.org/
  • Hochrein, Hubertus; Kirschning, Carsten Jürgen
    Bacteria evade immune recognition via TLR13 and binding of their 23S rRNA by MLS antibiotics by the same mechanisms
    In: OncoImmunology Vol. 2 (2013) Nr. 3, e23141
    Online Full Text: dx.doi.org/
  • Reimer, Elisa; Somplatzki, Stefan; Zegenhagen, Diana; Hänel, Svenja; Fels, Alina; Bollhorst, Thorsten; Grosse-Hovest, Ludger; Bauer, Stefan; Kirschning, Carsten Jürgen; Böldicke, Thomas
    Molecular cloning and characterization of a novel anti-TLR9 intrabody
    In: Cellular and Molecular Biology Letters Vol. 18 (2013) Nr. 3, pp. 433 - 446
    Online Full Text: dx.doi.org/
  • Muntasell, Aura; Costa-Garcia, Marcel; Vera, Andrea; Marina-Garcia, Noemí; Kirschning, Carsten Jürgen; López-Botet, Miguel
    Priming of NK cell anti-viral effector mechanisms by direct recognition of human cytomegalovirus
    In: Frontiers in Immunology Vol. 4 (2013) pp. 40
    Online Full Text: dx.doi.org/ (Open Access)
  • Kerur, Nagaraj; Hirano, Yoshio; Tarallo, Valeria; Fowler, Benjamin J.; Bastos-Carvalho, Ana; Yasuma, Tetsuhiro; Yasuma, Reo; Kim, Younghee; Hinton, David R.; Kirschning, Carsten Jürgen; Gelfand, Bradley D.; Ambati, Jayakrishna
    TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy
    In: Investigative Ophthalmology & Visual Science, IOVS Vol. 54 (2013) Nr. 12, pp. 7395 - 7401
    Online Full Text: dx.doi.org/
  • Desel, Christiane; Werninghaus, Kerstin; Ritter, Manuel; Jozefowski, Katrin; Wenzel, Jens; Russkamp, Norman; Schleicher, Ulrike; Christensen, Dennis; Wirtz, Stefan; Kirschning, Carsten Jürgen; Agger, Else Marie; Prazeres da Costa, Clarissa; Lang, Roland
    The Mincle-activating adjuvant TDB induces MyD88-dependent Th1 and Th17 responses through IL-1R signaling
    In: PLoS ONE Vol. 8 (2013) Nr. 1, pp. e53531
    Online Full Text: dx.doi.org/ (Open Access)
  • Eigenbrod, Tatjana; Franchi, Luigi; Muñoz-Planillo, Raul; Kirschning, Carsten Jürgen; Freudenberg, Marina A.; Núñez, Gabriel; Dalpke, Alexander
    Bacterial RNA mediates activation of caspase-1 and IL-1β release independently of TLRs 3, 7, 9 and TRIF but is dependent on UNC93B
    In: The Journal of Immunology (JI) Vol. 189 (2012) Nr. 1, pp. 328 - 336
    Online Full Text: dx.doi.org/
  • Schwandt, Timo; Schumak, Beatrix; Gielen, Gerrit H.; Jüngerkes, Frank; Schmidbauer, Patricia; Klocke, Katrin; Staratschek-Jox, Andrea; Van Rooijen, Niko; Kraal, Georg; Ludwig-Portugall, Isis; Franken, Lars; Wehner, Sven; Kalff, Jörg C.; Weber, Olaf; Kirschning, Carsten Jürgen; Coch, Christoph; Kalinke, Ulrich; Wenzel, Jörg; Kurts, Christian; Zawatzky, Rainer; Holzmann, Bernhard; Layland, Laura; Schultze, Joachim L.; Burgdorf, Sven; Den Haan, Joke M.M.; Knolle, Percy A.; Limmer, Andreas
    Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis
    In: The EMBO Journal Vol. 31 (2012) Nr. 1, pp. 201 - 213
    Online Full Text: dx.doi.org/
  • Welsch, Janina; Hübschle, Thomas; Murgott, Jolanta; Kirschning, Carsten Jürgen; Rummel, Christoph; Gerstberger, Rüdiger; Roth, Joachim
    Fever induction by systemic stimulation with macrophage-activating lipopeptide-2 depends upon TLR2 but not CD36
    In: Innate Immunity Vol. 18 (2012) Nr. 3, pp. 541 - 559
    Online Full Text: dx.doi.org/
  • Krueger, A.; Oldenburg, M.; Ferstl, R.; Sigmund, A.; Akira, S.; Kawai, T.; Buer, Jan; Wagner, H.; Bauer, Sebastian; Hochrein, H.; Kirschning, Carsten Jürgen
    Neutralization of pathogenic Gram-positive bacteria by macrophages is independent from TLR2,-3,-4,-7, and-9 yet depends upon MyD88
    In: Immunology Vol. 137 (2012) Nr. Suppl. 1, pp. 299 - 299
  • Bekeredjian-Ding, Isabelle; Foermer, Sandra; Kirschning, Carsten Jürgen; Parcina, Marijo; Heeg, Klaus
    Poke weed mitogen requires toll-like receptor ligands for proliferative activity in human and murine b lymphocytes
    In: PLoS ONE Vol. 7 (2012) Nr. 1,
    Online Full Text: dx.doi.org/ (Open Access)
  • Gamrekelashvili, Jaba; Ormandy, Lars A.; Heimesaat, Markus M.; Kirschning, Carsten Jürgen; Manns, Michael P.; Korangy, Firouzeh; Greten, Tim F.
    Primary sterile necrotic cells fail to cross-prime CD8⁺ T cells
    In: OncoImmunology Vol. 1 (2012) Nr. 7, pp. 1017 - 1026
    Online Full Text: dx.doi.org/
  • Ganal, Stephanie C.; Sanos, Stephanie L.; Kallfass, Carsten; Oberle, Karin; Johner, Caroline; Kirschning, Carsten; Lienenklaus, Stefan; Weiss, Siegfried; Staeheli, Peter; Aichele, Peter; Diefenbach, Andreas
    Priming of Natural Killer Cells by Nonmucosal Mononuclear Phagocytes Requires Instructive Signals from Commensal Microbiota
    In: Immunity Vol. 37 (2012) Nr. 1, pp. 171 - 186
    Online Full Text: dx.doi.org/
  • Sigmund, Alexander; Dreher, S.; Wagner, H.; Weitkunat, M.; Kirschning, Carsten Jürgen
    TLR- NOX2 interaction-driven oxidative burst
    In: Immunology Vol. 137 (2012) Nr. Suppl. 1, pp. 4 - 4
  • Oldenburg, Marina; Krüger, Anne; Ferstl, Ruth; Kaufmann, Andreas; Nees, Gernot; Sigmund, Anna; Bathke, Barbara; Lauterbach, Henning; Suter, Mark; Dreher, Stefan; Koedel, Uwe; Akira, Shizuo; Kawai, Taro; Buer, Jan; Wagner, Hermann; Bauer, Stefan; Hochrein, Hubertus; Kirschning, Carsten Jürgen
    TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance - Forming modification
    In: Science Vol. 337 (2012) Nr. 6098, pp. 1111 - 1115
    Online Full Text: dx.doi.org/
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