ZMB Member Andrea Musacchio
ZMB Member
Andrea Musacchio
Next ZMB-Member
Prof. Dr. Andrea Musacchio
Group
Mechanistic Cell BiologyMax Planck institute of Molecular Physiology
Otto-Hahn-Staße 11
44227 Dortmund
- +49 231 133 2101
- Website
- Selected Publications
- Publication Metrics
- ZMB Research Program
Molecular and Chemical Cell Biology
Research Overview
- Spindle assembly checkpoint components and functions
- Spindle assembly checkpoint (SAC) signalling
- Mitotic checkpoint complex (MCC)
- Anaphase-promoting complex (APC/C)
- Structural organization of the kinetochore
- Analyses of localization dependencies of kinetochore proteins
- Kinetochore receptors of checkpoint components
- Kinetochore–microtubule attachment
- Homeostatic control of mitotic arrest
- Sensitivity of cancer cells to antitubulin chemotherapeutics
Selected Publications
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A validation strategy to assess the role of phase separation as a determinant of macromolecular localizationIn: Molecular Cell Vol. 84 (2024) Nr. 9, pp. 1783 - 1801.e7Online Full Text: dx.doi.org/ (Open Access)
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Structure of the human inner kinetochore CCAN complex and its significance for human centromere organizationIn: Molecular Cell Vol. 82 (2022) Nr. 11, pp. 2113 - 2131.e8Online Full Text: dx.doi.org/ (Open Access)
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BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in MitosisIn: Molecular Cell Vol. 81 (2021) Nr. 1, pp. 67 - 87.e9Online Full Text: dx.doi.org/ (Open Access)
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Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80.In: Molecular Cell Vol. 71 (2018) Nr. 6, pp. 923 - 939.e10Online Full Text: dx.doi.org/ (Open Access)
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Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme FormationIn: Molecular Cell Vol. 72 (2018) Nr. 4, pp. 766 - 777Online Full Text: dx.doi.org/ (Open Access)
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Basis of catalytic assembly of the mitotic checkpoint complexIn: Nature Vol. 542 (2017) Nr. 7642, pp. 498 - 502Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Insights from biochemical reconstitution into the architecture of human kinetochoresIn: Nature Vol. 537 (2016) Nr. 7619, pp. 249 - 253Online Full Text: dx.doi.org/
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Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human KinetochoresIn: Cell Vol. 167 (2016) Nr. 4, pp. 1028 - 1040.e15Online Full Text: dx.doi.org/ (Open Access)
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The (phospho) needle in the (MELT) haystackIn: Molecular Cell Vol. 57 (2015) Nr. 5, pp. 765 - 766Online Full Text: dx.doi.org/ (Open Access)
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Modular Assembly of RWD Domains on the Mis12 Complex Underlies Outer Kinetochore OrganizationIn: Molecular Cell Vol. 53 (2014) Nr. 4, pp. 591 - 605Online Full Text: dx.doi.org/ (Open Access)
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Travel notes from the equatorial circleIn: Cell Vol. 146 (2011) Nr. 4, pp. 499 - 501Online Full Text: dx.doi.org/
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Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complexIn: Cell Vol. 133 (2008) Nr. 3, pp. 427 - 439Online Full Text: dx.doi.org/
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The Mad2 conformational dimer : structure and implications for the spindle assembly checkpointIn: Cell Vol. 131 (2007) Nr. 4, pp. 730 - 743Online Full Text: dx.doi.org/
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Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitinIn: Cell Vol. 124 (2006) Nr. 6, pp. 1183 - 1195Online Full Text: dx.doi.org/
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Kinetochore microtubule dynamics and attachment stability are regulated by Hec1In: Cell Vol. 127 (2006) Nr. 5, pp. 969 - 982Online Full Text: dx.doi.org/
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Atomic structure of clathrin : a β propeller terminal domain joins an α zigzag linkerIn: Cell Vol. 95 (1998) Nr. 4, pp. 563 - 573Online Full Text: dx.doi.org/
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Crystal structure of a Src-homology 3 (SH3) domainIn: Nature Vol. 359 (1992) Nr. 6398, pp. 851 - 855Online Full Text: dx.doi.org/