ZMB Member Manuela Wülling
ZMB Member
Manuela Wülling
Next ZMB-Member
Dr. Manuela Wülling
Center of Medical Biotechnology (ZMB)
Faculty of Biology
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen
- +49 201 183 2297
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- ZMB Research Program
Molecular and Chemical Cell Biology
The main interest of the group are the transcriptional mechanisms that govern chondrocyte development and pathology. Dysregulation of chondrocyte proliferation and differentiation lead to shortened and malformed endochondral bones and the degenerative diseases of the connecting joints. Our goal is to decipher how transcriptional cascades interact to coordinate cell cycle progression and differentiation of skeletal cells. Epigenetic modifiers link chromatin structure to the transcriptional output. Changes in epigenetic profiles have been reported to affect pathological processes like osteoarthritis. Using next generation sequencing technologies, we are currently integrating epigenetic and transcriptional profiles to understand how alterations in chromatin structure and transcription factor binding affect skeletal development and disease.
Publications
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Epigenetic mechanisms mediating cell state transitions in chondrocytesIn: Journal of Bone and Mineral Research (JBMR) Vol. 36 (2021) Nr. 5, pp. 968 - 985Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Wnt5a is a transcriptional target of Gli3 and Trps1 at the onset of chondrocyte hypertrophyIn: Developmental Biology Vol. 457 (2020) Nr. 1, pp. 104 - 118Online Full Text: dx.doi.org/ (Open Access)
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A network of trans-cortical capillaries as mainstay for blood circulation in long bonesIn: Nature Metabolism Vol. 1 (2019) Nr. 2, pp. 236 - 250Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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A newly discovered stem cell that keeps bones growingIn: Nature Vol. 567 (2019) Nr. 7747, pp. 178 - 179Online Full Text: dx.doi.org/ (Open Access)
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Atoh8 acts as a regulator of chondrocyte proliferation and differentiation in endochondral bonesIn: PLoS ONE Vol. 14 (2019) Nr. 8, pp. e0218230
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Signaling systems affecting the severity of multiple osteochondromasIn: Bone: Official Journal of the International Bone and Mineral Society (IBMS) Vol. 111 (2018) pp. 71 - 81Online Full Text: dx.doi.org/ (Open Access)
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Epigenetic regulation of chondrocyte differentiation
18th International Congress of Developmental Biology, 18-22 June, Singapore,In: Mechanisms of Development Vol. 145 (2017) Nr. Supplement: 18th International Congress of Developmental Biology 18-22 June, University Cultural Centre, National University of Singapore, pp. S141Online Full Text: dx.doi.org/ -
CCN1 (CYR61) and CCN3 (NOV) signaling drives human trophoblast cells into senescence and stimulates migration propertiesIn: Cell Adhesion & Migration Vol. 10 (2016) Nr. 1-2, pp. 163 - 178Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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CCN3 signaling is dysregulated in the pregnancy disorder preeclampsiaIn: Journal of Reproductive Immunology Vol. 115 (2016) pp. 71 - 71Online Full Text: dx.doi.org/
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Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling, swelling, and protein cleavageIn: The FASEB Journal Vol. 30 (2016) Nr. 2, pp. 727 - 737Online Full Text: dx.doi.org/
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Anoctamin-6 Controls Bone Mineralization by Activating the Calcium Transporter NCX1In: The Journal of Biological Chemistry (JBC) Vol. 290 (2015) Nr. 10, pp. 6270 - 6280Online Full Text: dx.doi.org/ (Open Access)
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CCN3 (NOV) : A key player in trophoblast differentiation promoting cell cycle exit and migration of extravillous trophoblast cells and its role in preeclampsiaIn: Placenta Vol. 35 (2014) Nr. 9, pp. A108Online Full Text: dx.doi.org/
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Inactivation of Patched1 in murine chondrocytes causes spinal fusion without inflammationIn: Arthritis & Rheumatology Vol. 66 (2014) Nr. 4, pp. 831 - 840Online Full Text: dx.doi.org/
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Inactivation of anoctamin-6/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissuesIn: Journal of Bone and Mineral Research (JBMR) Vol. 28 (2013) Nr. 2, pp. 246 - 259Online Full Text: dx.doi.org/
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The multi zinc-finger protein Trps1 acts as a regulator of histone deacetylation during mitosisIn: Cell Cycle Vol. 12 (2013) Nr. 14, pp. 2219 - 2232Online Full Text: dx.doi.org/
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Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in miceIn: PLoS ONE Vol. 7 (2012) Nr. 8, pp. e43553Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Prdm5 Regulates Collagen Gene Transcription by Association with RNA Polymerase II in Developing BoneIn: PLoS Genetics Vol. 8 (2012) Nr. 5, pp. e1002711Online Full Text: dx.doi.org/ (Open Access)
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BMP signaling balances proliferation and differentiation of muscle satellite cell descendants.In: BMC Cell Biology Vol. 12 (2011) pp. 26Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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The resorption of nanocrystalline calcium phosphates by osteoclast-like cellsIn: Acta Biomaterialia Vol. 6 (2010) Nr. 8, pp. 3223 - 3233Online Full Text: dx.doi.org/
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Transcriptional networks controlling chondrocyte proliferation and differentiation during endochondral ossification.In: Pediatric Nephrology Vol. 25 (2010) Nr. 4, pp. 625 - 631Online Full Text: dx.doi.org/
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Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3In: Developmental Biology Vol. 328 (2009) Nr. 1, pp. 40 - 53Online Full Text: dx.doi.org/
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Tricho-rhino-phalangeal syndrome with supernumerary teethIn: Journal of Dental Research: JDR Online Vol. 87 (2008) Nr. 11, pp. 1027 - 1031Online Full Text: dx.doi.org/
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Ucma - A novel secreted factor represents a highly specific marker for distal chondrocytesIn: Matrix Biology Vol. 27 (2008) Nr. 1, pp. 3 - 11Online Full Text: dx.doi.org/
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The role of growth factors in chondrogenesis and osteogenesisIn: Current Opinion in Orthopaedics Vol. 17 (2006) pp. 405 - 411Online Full Text: dx.doi.org/
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Gli3 has repressing and activating functions downstream of Ihh in regulating two distinct steps of chondrocyte differentiationIn: Development / Company of Biologists Vol. 132 (2005) Nr. 23, pp. 5249 - 5260Online Full Text: dx.doi.org/
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Model systems for human muscoskeletal diseasesIn: Drug Discovery Today: Disease Models Vol. 1 (2004) Nr. 3, pp. 359 - 364Online Full Text: dx.doi.org/