ZMB Member Barbara Saccà
ZMB Member
Barbara Saccà
Next ZMB-Member
Prof. Dr. Barbara Saccà
Group
BionanotechnologyCenter of Medical Biotechnology (ZMB)
Faculty of Biology
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen
- +49 201 183 3395
- Website
- Selected Publications
- Publication Metrics
- ZMB Research Program
Molecular and Chemical Cell Biology
Research Overview
We use DNA nanotechnology to construct simplified models of complex biological systems, where single structural and functional parameters can be manipulated in a predictable fashion. Our scientific ambition is to gain a better understanding of three fundamental aspects of natural self-assembling systems: hierarchical order, spatial confinement, and dynamic response.
Read moreSelected Publications
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A modular DNA origami nanocompartment for engineering a cell-free, protein unfolding and degradation pathwayIn: Nature Nanotechnology Vol. 19 (2024) Nr. 10, pp. 1521 - 1531Online Full Text: dx.doi.org/ (Open Access)
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The primordial life of DNA dynamic networksIn: Nature Catalysis Vol. 3 (2020) Nr. 11, pp. 865 - 866Online Full Text: dx.doi.org/
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Sites of high local frustration in DNA origamiIn: Nature Communications Vol. 10 (2019) Nr. 1, pp. 1061Online Full Text: dx.doi.org/ (Open Access)
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Hierarchical Assembly of DNA Filaments with Designer Elastic PropertiesIn: ACS Nano Vol. 12 (2018) Nr. 1, pp. 44 - 55Online Full Text: dx.doi.org/
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Tailored protein encapsulation into a DNA host using geometrically organized supramolecular interactionsIn: Nature Communications Vol. 8 (2017) pp. 14472Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Characterizing the Effect of Multivalent Conjugates Composed of Aβ-Specific Ligands and Metal Nanoparticles on Neurotoxic Fibrillar AggregationIn: ACS Nano (2016) pp. 7582 - 7597Online Full Text: dx.doi.org/
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Determinants of amyloid fibril degradation by the PDZ protease HTRA1In: Nature Chemical Biology Vol. 11 (2015) Nr. 11, pp. 862 - 869Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Reversible reconfiguration of DNA origami nanochambers monitored by single-molecule FRETIn: Angewandte Chemie International Edition Vol. 54 (2015) Nr. 12, pp. 3592 - 3597Online Full Text: dx.doi.org/
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Site-Directed, on-surface assembly of DNA nanostructuresIn: Angewandte Chemie International Edition Vol. 54 (2015) Nr. 41, pp. 12039 - 12043Online Full Text: dx.doi.org/
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DNA Origami : The Art of Folding DNAIn: Angewandte Chemie International Edition Vol. 51 (2012) Nr. 1, pp. 58 - 66Online Full Text: dx.doi.org/
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Functionalization of DNA nanostructures with proteinsIn: Chemical Society Reviews Vol. 40 (2011) Nr. 12, pp. 5910 - 5921Online Full Text: dx.doi.org/
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Orthogonal Protein Decoration of DNA OrigamiIn: Angewandte Chemie International Edition Vol. 49 (2010) Nr. 49, pp. 9378 - 9383Online Full Text: dx.doi.org/
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Dendritic DNA Building Blocks for Amplified Detection Assays and BiomaterialsIn: Angewandte Chemie International Edition Vol. 48 (2009) Nr. 33, pp. 5996 - 6000Online Full Text: dx.doi.org/
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High-Throughput, Real-Time Monitoring of the Self-Assembly of DNA Nanostructures by FRET SpectroscopyIn: Angewandte Chemie International Edition Vol. 47 (2008) Nr. 11, pp. 2135 - 2137Online Full Text: dx.doi.org/
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Kinetics of tetramolecular quadruplexesIn: Nucleic Acids Research Vol. 33 (2005) Nr. 1, pp. 81 - 94Online Full Text: dx.doi.org/
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Length-dependent energetics of (CTG)n and (CAG)n trinucleotide repeatsIn: Nucleic Acids Research Vol. 33 (2005) Nr. 13, pp. 4065 - 4077Online Full Text: dx.doi.org/
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The effect of chemical modifications on the thermal stability of different G-quadruplex-forming oligonucleotidesIn: Nucleic Acids Research Vol. 33 (2005) Nr. 4, pp. 1182 - 1192Online Full Text: dx.doi.org/