AG Kathrin Sutter

Forschungsschwerpunkte

  • Typ I Interferone: Immunmodulation und antivirale Therapie
  • Interferon-alpha Subtypen
  • Modulation von Immunzellen
  • Immuntherapien
  • chronische Virusinfektionen (HIV, HBV)
  • IFN-stimulierte Gene
  • NK-Zellen 

Projekt

Während den meisten Virusinfektionen ist die erste Immunantwort charakterisiert durch die Induktion von Typ I Interferon (IFN). IFN gehört zu einer Genfamilie, welche bis zu 13 verschiedene IFN-α Subtypen und IFN-β mit einschließt. Diese Interferone weisen alle unterschiedliche biologische Aktivitäten auf wie z.B. antivirale, anti-proliferative und immunmodulatorische Eigenschaften. Nach ihrer Induktion, binden alle Interferone an den gleichen Rezeptor, was zu der Expression zahlreicher verschiedener IFN-stimulierter Gene führt, welche für antivirale Proteine kodieren, die direkt die virale Replikation inhibieren wie auch die Funktion von Immunzellen modulieren. Daher ist die Induktion von Typ I IFN ein wirkungsvolles Mittel gegen Virusinfektionen anzukämpfen. Viele Viren haben Wege gefunden der IFN-Antwort zu entgehen. Deshalb sollte die therapeutische Gabe von exogenem Typ I IFN ein großes Potential für zukünftige Immuntherapien gegen Virusinfektionen besitzen. Die Arbeitsgruppe ist hauptsächlich interessiert an den verschiedenen antiviralen und immunmodulatorischen Eigenschaften aller humanen und murinen IFN-α Subtypen in akuten und chronischen Virusinfektionen. Ein besonderer Augenmerk liegt auf der Induktion der verschiedenen Subtypen, deren Regulation und ihren erschiedenen biologischen Eigenschaften besonders die Modulation von Immunantworten. 

During most viral infections, the immediate host response is characterized by an induction of type I Interferon (IFN). IFN belongs to a multigene family that includes up to 13 different IFN-α subtypes and IFN-β, which have various biological activities, including anti-viral, anti-proliferative and immunomodulatory effects. After induction, they all bind to the same receptor, which results in the expression of numerous different IFN-stimulated genes which encode anti-viral proteins that directly inhibit viral replication as well as modulate immune function. Thus, the induction of type I IFN is a very powerful tool for the host to fight virus infections. Many viruses evade this response by various strategies. Therefore, the therapeutic application of exogenous type I IFN should be of great potential for future immunotherapies against viral infections. The research group is mainly focusing on the various antiviral and immunomodulatory activities of the different human and murine IFN-α subtypes in acute and chronic viral infections. We are interested in the induction of the subtypes, their regulation and their different biological activities especially the modulation of immune responses.

Arbeitsgruppe

group leader

​Kathrin Sutter
​
​PD Dr. rer nat. Kathrin Sutter (geb. Gibbert)
kathrin.sutter@uni-due.de
0201-723-83250

PhD Student

B. Sc. Mara Schwerdtfeger
Raum 2.051
0201-723-4050
mara.schwerdtfeger@uk-essen.de

PhD Student

M. Sc. Zehra Karaköse
Raum 2.051
0201-723-4224
zehra.karakoese@uk-essen.de

Bachelor Student

Julia Boesner
Raum 2.051
0201-723-4050

(MTA)

Sandra Francois
Raum 2.061
0201-723-83737
Sandra.francois@uk-essen.de

Ausgewählte Publikationen

2023

  • Kruth, Carolin; Schwarzer-Sperber, Hannah; Esser, Stefan; Dittmer, Ulf; Schwarzer, Roland; Sutter, Kathrin;
    Effects of type I interferons on HIV latency
    DÖAK 2023 / German-Austrian AIDS Conference, Bonn, Germany, 23-25 March 2023,
    In: HIV Medicine Vol. 24 (2023) Nr. S1, pp. 82
    ISSN: 1464-2662; 1468-1293
  • Li, Ziwei; Xiang, Tiandan; Liang, Boyun; Liu, Jing; Deng, Hui; Yang, Xuecheng; Wang, Hua; Feng, Xuemei; Zelinskyy, Gennadiy; Trilling, Mirko; Sutter, Kathrin; Lu, Mengji; Dittmer, Ulf; Wang, Baoju; Yang, Dongliang; Zheng, Xin; Liu, Jia
    SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection
    In: Virologica Sinica (2023) in press
    ISSN: 1995-820X; 1674-0769
    Online Full Text: dx.doi.org/ (Open Access)
  • Karakoese, Zehra; Schwerdtfeger, Mara; Karsten, Christina; Esser, Stefan; Dittmer, Ulf; Sutter, Kathrin;
    Distinct type I interferon subtypes differentially stimulate T cell responses in HIV1-infected individuals
    DÖAK 2023 / German-Austrian AIDS Conference, Bonn, Germany, 23-25 March 2023,
    In: HIV Medicine Vol. 24 (2023) Nr. 1, pp. 92
    ISSN: 1464-2662; 1468-1293
  • Wang, Qin; Liu, Yanan; Luo, Jinzhuo; Yang, Shangqing; Wang, Lu; Lu, Yinping; Feng, Xuemei; Yang, Xuecheng; Sutter, Kathrin; Dittmer, Ulf; Lu, Mengji; Zheng, Xin; Yang, Dongliang; Liu, Jia
    A systematic comparison reveals dynamic differences in early adaptive immune responses of acute-resolving versus chronic HBV replication
    In: Journal of Medical Virology Vol. 95 (2023) Nr. 3,
    ISSN: 0146-6615; 1096-9071
    Online Full Text: dx.doi.org/ (Open Access)

2022

  • Meister, Toni Luise; Brüggemann, Yannick; Nocke, Maximilian K.; Ulrich, Rainer G.; Schuhenn, Jonas; Sutter, Kathrin; Gömer, André; Bader, Verian; Winklhofer, Konstanze F.; Bröring, Ruth; Verhoye, Lieven; Meuleman, Philip; Vondran, Florian W. R.; Camuzet, Charline; Cocquerel, Laurence; Todt, Daniel; Steinmann, Eike
    A ribavirin-induced ORF2 single-nucleotide variant produces defective hepatitis E virus particles with immune decoy function
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 119 (2022) Nr. 34,
    ISSN: 1091-6490; 0027-8424
    Online Full Text: dx.doi.org/ (Open Access)
  • Wenzek, Christina; Steinbach, Philine; Wirsdörfer, Florian; Sutter, Kathrin; Boehme, Julia D.; Geffers, Robert; Klopfleisch, Robert; Bruder, Dunja; Jendrossek, Verena; Buer, Jan; Westendorf, Astrid; Knuschke, Torben
    CD47 restricts antiviral function of alveolar macrophages during influenza virus infection
    In: iScience Vol. 25 (2022) Nr. 12,
    ISSN: 2589-0042
    Online Full Text: dx.doi.org/
  • Karakoese, Zehra; Schwerdtfeger, Mara; Karsten, Christina; Esser, Stefan; Dittmer, Ulf; Sutter, Kathrin
    Distinct Type I Interferon Subtypes Differentially Stimulate T Cell Responses in HIV-1-Infected Individuals
    In: Frontiers in Immunology Vol. 13 (2022)
    ISSN: 1664-3224
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Xie, Xiaohong; Karakoese, Zehra; Ablikim, Dilhumare; Ickler, Julia; Schuhenn, Jonas; Zeng, Xiaoqing; Feng, Xuemei; Yang, Xuecheng; Dittmer, Ulf; Yang, Dongliang; Sutter, Kathrin; Liu, Jia
    IFNα subtype-specific susceptibility of HBV in the course of chronic infection
    In: Frontiers in Immunology Vol. 13 (2022)
    ISSN: 1664-3224
    Online Full Text: dx.doi.org/ (Open Access)
  • Sertznig, Helene; Roesmann, Fabian; Wilhelm, Alexander; Heininger, Delia; Bleekmann, Barbara; Elsner, Carina; Santiago, Mario; Schuhenn, Jonas; Karakoese, Zehra; Benatzy, Yvonne; Snodgrass, Ryan; Esser, Stefan; Sutter, Kathrin; Dittmer, Ulf; Widera, Marek
    SRSF1 acts as an IFN-I-regulated cellular dependency factor decisively affecting HIV-1 post-integration steps
    In: Frontiers in Immunology Vol. 13 (2022)
    ISSN: 1664-3224
    Online Full Text: dx.doi.org/ (Open Access)
  • Schmitz, Yasmin; Schwerdtfeger, Mara; Westmeier, Jaana; Littwitz-Salomon, Elisabeth; Alt, Mira; Brochhagen, Leonie; Krawczyk, Adalbert; Sutter, Kathrin
    Superior antiviral activity of IFNβ in genital HSV-1 infection
    In: Frontiers in Cellular and Infection Microbiology Vol. 12 (2022)
    ISSN: 2235-2988
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Hussain, Timon; Domnich, Maksim; Bordbari, Sharareh; Pylaeva, Ekaterina; Siakaeva, Elena; Spyra, Ilona; Ozel, Irem; Droege, Freya; Squire, Anthony; Lienenklaus, Stefan; Sutter, Kathrin; Hasenberg, Anja; Gunzer, Matthias; Lang, Stephan; Jablonska, Jadwiga
    IFNAR1 Deficiency Impairs Immunostimulatory Properties of Neutrophils in Tumor-Draining Lymph Nodes
    In: Frontiers in Immunology Vol. 13 (2022)
    ISSN: 1664-3224
    Online Full Text: dx.doi.org/ (Open Access)
  • David, Paul; Westmeier, Jaana; Drabczyk-Pluta, Malgorzata; Werner, Tanja; Ickler, Julia; Francois, Sandra; Bayer, Wibke; Sutter, Kathrin; Del Rio, Maria Luisa; Rodriguez-Barbosa, Jose-Ignacio; Dittmer, Ulf; Zelinskyy, Gennadiy
    The Role of the Inhibitory Ligand HVEM and Its Receptors CD160 and BTLA in the Regulation of Anti-retroviral T Cell Responses
    In: Frontiers in Virology Vol. 2 (2022)
    ISSN: 2673-818X
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Schuhenn, Jonas; Meister, Toni Luise; Todt, Daniel; Bracht, Thilo; Schork, Karin; Billaud, Jean-Noel; Elsner, Carina; Heinen, Natalie; Karakoese, Zehra; Haid, Sibylle; Kumar, Sriram; Brunotte, Linda; Eisenacher, Martin; Di, Yunyun; Lew, Jocelyne; Falzarano, Darryl; Chen, Jieliang; Yuan, Zhenghong; Pietschmann, Thomas; Wiegmann, Bettina; Uebner, Hendrik; Taube, Christian; Le-Trilling, Vu Thuy Khanh; Trilling, Mirko; Krawczyk, Adalbert; Ludwig, Stephan; Sitek, Barbara; Steinmann, Eike; Dittmer, Ulf; Lavender, Kerry J.; Sutter, Kathrin; Pfaender, Stephanie
    Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 119 (2022) Nr. 8,
    ISSN: 1091-6490; 0027-8424
    Online Full Text: dx.doi.org/ (Open Access)
  • Sperber, Hannah Sabeth; Sutter, Kathrin; Müller, Karin; Müller, Peter; Schwarzer, Roland
    The Bovine Seminal Plasma Protein PDC-109 Possesses Pan-Antiviral Activity
    In: Viruses Vol. 14 (2022) Nr. 9,
    ISSN: 1999-4915
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Rout, Saurav S.; Di, Yunyun; Dittmer, Ulf; Sutter, Kathrin; Lavender, Kerry J.
    Distinct effects of treatment with two different interferon-alpha subtypes on HIV-1-associated T-cell activation and dysfunction in humanized mice
    In: AIDS Vol. 36 (2022) Nr. 3, pp. 325 - 336
    ISSN: 0269-9370; 1473-5571
    Online Full Text: dx.doi.org/
  • Schwerdtfeger, Mara; Dickow, Julia; Schmitz, Yasmin; Francois, Sandra; Karakoese, Zehra; Malyshkina, Anna; Knuschke, Torben; Dittmer, Ulf; Sutter, Kathrin
    Immunotherapy With Interferon α11, But Not Interferon Beta, Controls Persistent Retroviral Infection
    In: Frontiers in Immunology Vol. 12 (2022)
    ISSN: 1664-3224
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)

2021

  • Li, Ziwei; Xiang, Tiandan; Liang, Boyun; Deng, Hui; Wang, Hua; Feng, Xuemei; Quan, Xufeng; Wang, Xiaoyan; Li, Sumeng; Lu, Sihong; Yang, Xuecheng; Wang, Baoju; Zelinskyy, Gennadiy; Trilling, Mirko; Sutter, Kathrin; Lu, Mengji; Dittmer, Ulf; Yang, Dongliang; Zheng, Xin; Liu, Jia
    Characterization of SARS-CoV-2-Specific Humoral and Cellular Immune Responses Induced by Inactivated COVID-19 Vaccines in a Real-World Setting
    In: Frontiers in Immunology Vol. 12 (2021)
    ISSN: 1664-3224
    Online Full Text: dx.doi.org/ (Open Access)
  • Wienhöfer, Lisa; Marker, Max; Antoni, Anne-Charlotte; Sutter, Kathrin; Sander, André; Dudda, Marcel; Flohe, Stefanie
    TLR4 Transactivates CD8⁺ T Lymphocytes upon Acute Sterile Tissue Injury
    In: ImmunoHorizons Vol. 5 (2021) Nr. 5, pp. 298 - 306
    ISSN: 2573-7732
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Liu, Jia; Yang, Xuecheng; Wang, Hua; Li, Ziwei; Deng, Hui; Liu, Jing; Xiong, Shue; He, Junyi; Feng, Xuemei; Guo, Chunxia; Wang, Weixian; Zelinskyy, Gennadiy; Trilling, Mirko; Sutter, Kathrin; Senff, Tina; Menne, Christopher; Timm, Jörg; Zhang, Yanfang; Deng, Fei; Lu, Yinping; Wu, Jun; Lu, Mengji; Yang, Dongliang; Dittmer, Ulf; Wang, Baoju; Zheng, Xin
    Analysis of the long-term impact on cellular immunity in COVID-19-recovered individuals reveals a profound nkt cell impairment
    In: mBio Vol. 12 (2021) Nr. 2, pp. e00085 - 21
    ISSN: 2150-7511; 2161-2129
    Online Full Text: dx.doi.org/ (Open Access)
  • Xiong, Shue; Zhu, Dan; Liang, Boyun; Li, Mingyue; Pan, Wen; He, Junyi; Wang, Hua; Sutter, Kathrin; Dittmer, Ulf; Lu, Mengji; Liu, Di; Yang, Dongliang; Liu, Jia; Zheng, Xin
    Longitudinal characterization of phenotypic profile of T cells in chronic hepatitis B identifies immune markers associated with HBsAg loss
    In: EBioMedicine Vol. 69 (2021)
    ISSN: 2352-3964
    Online Full Text: dx.doi.org/ (Open Access)
  • Chen, Jieliang; Li, Yaming; Lai, Fritz; Wang, Yang; Sutter, Kathrin; Dittmer, Ulf; Ye, Jianyu; Zai, Wenjing; Liu, Min; Shen, Fang; Wu, Min; Hu, Kongying; Li, Baocun; Lu, Mengji; Zhang, Xiaonan; Zhang, Jiming; Li, Jianhua; Chen, Qingfeng; Yuan, Zhenghong
    Functional Comparison of Interferon-α Subtypes Reveals Potent Hepatitis B Virus Suppression by a Concerted Action of Interferon-α and Interferon-γ Signaling
    In: Hepatology Vol. 73 (2021) Nr. 2, pp. 486 - 502
    ISSN: 1527-3350; 0270-9139
    Online Full Text: dx.doi.org/

2020

  • Sutter, Kathrin
    Die Einmischer: Interferone : Wie sie die Immunantwort beeinflussen, um Viren effektiv zu bekämpfen
    In: Unikate: Berichte aus Forschung und Lehre (2020) Nr. 54: Medizin: Infektionskrankheiten - ein globales Problem, pp. 18 - 27
    ISSN: 0941-746X
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Guo, Kejun; Shen, Guannan; Kibbie, Jon; Gonzalez, Tania; Dillon, Stephanie M.; Smith, Harry A.; Cooper, Emily H.; Lavender, Kerry; Hasenkrug, Kim J.; Sutter, Kathrin; Dittmer, Ulf; Kroehl, Miranda; Kechris, Katerina; Wilson, Cara C.; Santiago, Mario L.
    Qualitative differences between the IFNα subtypes and IFNβ influence chronic mucosal HIV-1 pathogenesis
    In: PLoS Pathogens Vol. 16 (2020) Nr. 10, pp. 1008986
    ISSN: 1553-7374; 1553-7366
    Online Full Text: dx.doi.org/ (Open Access)
  • Heilingloh, Christiane Silke; Aufderhorst, Ulrich Wilhelm; Schipper, Leonie; Dittmer, Ulf; Witzke, Oliver; Yang, Dongliang; Zheng, Xin; Sutter, Kathrin; Trilling, Mirko; Alt, Mira; Steinmann, Eike; Krawczyk, Adalbert
    Susceptibility of SARS-CoV-2 to UV irradiation
    In: American Journal of Infection Control Vol. 48 (2020) Nr. 10, pp. 1273 - 1275
    ISSN: 1527-3296; 0196-6553
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Westmeier, Jaana; Paniskaki, Krystallenia; Karaköse, Zehra; Werner, Tanja; Sutter, Kathrin; Dolff, Sebastian; Overbeck, Marvin; Limmer, Andreas; Liu, Jia; Zheng, Xin; Brenner, Thorsten; Berger, Marc; Witzke, Oliver; Trilling, Mirko; Lu, Mengji; Yang, Dongliang; Babel, Nina; Westhoff, Timm; Dittmer, Ulf; Zelinskyy, Gennadiy
    Erratum for Westmeier et al., "Impaired Cytotoxic CD8⁺ T Cell Response in Elderly COVID-19 Patients"
    In: mBio Vol. 11 (2020) Nr. 5, pp. 02243 - 02220
    ISSN: 2150-7511; 2161-2129
    Online Full Text: dx.doi.org/ (Open Access)
  • Zutz, Ariane; Schölz, Christian; Schneider, Stephanie; Pierini, Virginia; Münchhoff, Maximilian; Sutter, Kathrin; Wittmann, Georg; Dittmer, Ulf; Draenert, Rika; Bogner, Johannes R.; Fackler, Oliver T.; Keppler, Oliver T.
    SERINC5 Is an Unconventional HIV Restriction Factor That Is Upregulated during Myeloid Cell Differentiation
    In: Journal of Innate Immunity Vol. 12 (2020) Nr. 5, pp. 399 - 409
    ISSN: 1662-8128; 1662-811X
    Online Full Text: dx.doi.org/ (Open Access)
  • Ickler, Julia; Francois, Sandra; Widera, Marek; Santiago, Mario L.; Dittmer, Ulf; Sutter, Kathrin
    HIV infection does not alter interferon α/β receptor 2 expression on mucosal immune cells
    In: PLoS ONE Vol. 15 (2020) Nr. 1, pp. e0218905
    ISSN: 1932-6203
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Liu, Jia; Zheng, Xin; Tong, Qiaoxia; Li, Wei; Wang, Baoju; Sutter, Kathrin; Trilling, Mirko; Lu, Mengji; Dittmer, Ulf; Yang, Dongliang
    Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV
    In: Journal of Medical Virology Vol. 92 (2020) Nr. 5, pp. 491 - 494
    ISSN: 0146-6615; 1096-9071
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Westmeier, Jaana; Paniskaki, Krystallenia; Karaköse, Zehra; Werner, Tanja; Sutter, Kathrin; Dolff, Sebastian; Overbeck, Marvin; Limmer, Andreas; Liu, Jia; Zheng, Xin; Brenner, Thorsten; Berger, Marc; Witzke, Oliver; Trilling, Mirko; Lu, Mengji; Yang, Dongliang; Babel, Nina; Westhoff, Timm; Dittmer, Ulf; Zelinskyy, Gennadiy
    Impaired cytotoxic CD8⁺ T cell response in elderly COVID-19 patients
    In: mBio Vol. 11 (2020) Nr. 5, pp. e02243 - 20
    ISSN: 2150-7511; 2161-2129
    Online Full Text: dx.doi.org/ (Open Access)

2019

 

  • Sutter, Kathrin; Lavender, Kerry J.; Messer, Ronald J.; Widera, Marek; Williams, Katie; Race, Brent; Hasenkrug, Kim J.; Dittmer, Ulf
    Concurrent administration of IFNα14 and cART in TKO-BLT mice enhances suppression of HIV-1 viremia but does not eliminate the latent reservoir
    In: Scientific Reports Vol. 9 (2019) pp. 18089
    ISSN: 2045-2322
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Matos, Aline da Rocha; Wunderlich, Katharina; Schloer, Sebastian; Schughart, Klaus; Geffers, Robert; Seders, Martine; Witt, Marlous de; Christersson, Anmari; Wiewrodt, Rainer; Wiebe, Karsten; Barth, Peter; Hocke, Andreas; Hippenstiel, Stefan; Hönzke, Katja; Dittmer, Ulf; Sutter, Kathrin; Rescher, Ursula; Rodionycheva, Svetlana; Matera, Nicoletta; Ludwig, Stephan; Brunotte, Linda
    Antiviral potential of human IFN-α subtypes against influenza A H3N2 infection in human lung explants reveals subtype-specific activities
    In: Emerging Microbes & Infections Vol. 8 (2019) Nr. 1, pp. 1763 - 1776
    ISSN: 2222-1751
    Online Full Text: dx.doi.org/ (Open Access)
  • Dittmer, Ulf; Sutter, Kathrin; Kassiotis, George; Zelinskyy, Gennadiy; Bánki, Zoltán; Stoiber, Heribert; Santiago, Mario L.; Hasenkrug, Kim J.
    Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity
    In: FEMS Microbiology Reviews Vol. 43 (2019) Nr. 5, pp. 435 - 456
    ISSN: 1574-6976; 0168-6445
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Passos, Vânia; Zillinger, Thomas; Casartelli, Nicoletta; Wachs, Amelie S.; Xu, Shuting; Malassa, Angelina; Steppich, Katja; Schilling, Hildegard; Franz, Sergej; Todt, Daniel; Steinmann, Eike; Sutter, Kathrin; Dittmer, Ulf; Bohne, Jens; Schwartz, Olivier; Barchet, Winfried; Goffinet, Christine
    Characterization of Endogenous SERINC5 Protein as Anti-HIV-1 Factor
    In: Journal of Virology Vol. 93 (2019) Nr. 24, pp. e01221 - 19
    ISSN: 1098-5514; 0022-538X
    Online Full Text: dx.doi.org/ (Open Access)
  • Dickow, Julia; Francois, Sandra; Kaiserling, Rouven-Luca; Malyshkina, Anna; Drexler, Ingo; Westendorf, Astrid Maria; Lang, Karl Sebastian; Santiago, Mario L.; Dittmer, Ulf; Sutter, Kathrin
    Diverse immunomodulatory effects of individual IFNα subtypes on virus-specific CD8⁺ T cell responses
    In: Frontiers in Immunology Vol. 10 (2019)
    ISSN: 1664-3224
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Hasenkrug, Kim J.; Lavender, Kerry J.; Santiago, Mario L.; Sutter, Kathrin; Dittmer, Ulf
    Different Biological Activities of Specific Interferon Alpha Subtypes
    In: mSphere Vol. 4 (2019) Nr. 4,
    ISSN: 2379-5042
    Online Full Text: dx.doi.org/ (Open Access)
  • Braun, Elisabeth; Hotter, Dominik; Koepke, Lennart; Zech, Fabian; Groß, Rüdiger; Sparrer, Konstantin M.J.; Müller, Janis A.; Pfaller, Christian K.; Heusinger, Elena; Wombacher, Rebecka; Sutter, Kathrin; Dittmer, Ulf; Winkler, Michael; Simmons, Graham; Jakobsen, Martin R.; Conzelmann, Karl-Klaus; Pöhlmann, Stefan; Münch, Jan; Fackler, Oliver T.; Kirchhoff, Frank; Sauter, Daniel
    Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins
    In: Cell Reports Vol. 27 (2019) Nr. 7, pp. 2092 - 2104.e10
    ISSN: 2211-1247
    Online Full Text: dx.doi.org/ (Open Access)
  • Xia, Yuchen; Schlapschy, Martin; Morath, Volker; Roeder, Natalie; Vogt, Elisabeth I.; Stadler, Daniela; Cheng, Xiaoming; Dittmer, Ulf; Sutter, Kathrin; Heikenwalder, Mathias; Skerra, Arne; Protzer, Ulrike
    PASylated interferon α efficiently suppresses hepatitis B virus and induces anti-HBs seroconversion in HBV-transgenic mice
    In: Antiviral Research Vol. 161 (2019) pp. 134 - 143
    ISSN: 1872-9096; 0166-3542
    Online Full Text: dx.doi.org/
  • Malyshkina, Anna; Littwitz-Salomon, Elisabeth; Sutter, Kathrin; Ross, Jean Alexander; Paschen, Annette; Windmann, Sonja; Schimmer, Simone; Dittmer, Ulf
    Chronic retroviral infection of mice promotes tumor development, but CD137 agonist therapy restores effective tumor immune surveillance
    In: Cancer Immunology, Immunotherapy Vol. 68 (2019) Nr. 3, pp. 479 - 488
    ISSN: 1432-0851; 0340-7004
    Online Full Text: dx.doi.org/
  • Gujer, Cornelia; Murer, Anita; Müller, Anne; Vanoaica, Danusia; Sutter, Kathrin; Jacque, Emilie; Fournier, Nathalie; Kalchschmidt, Jens; Zbinden, Andrea; Capaul, Riccarda; Dzionek, Andrzej; Mondon, Philippe; Dittmer, Ulf; Münz, Christian
    Plasmacytoid dendritic cells respond to Epstein-Barr virus infection with a distinct type I interferon subtype profile
    In: Blood Advances Vol. 3 (2019) Nr. 7, pp. 1129 - 1144
    ISSN: 2473-9537; 2473-9529
    Online Full Text: dx.doi.org/ (Open Access)

2018

  • Shen, Fang; Li, Yaming; Wang, Yang; Sozzi, Vitina; Revill, Peter A.; Liu, Jiangxia; Gao, Lu; Yang, Guang; Lu, Mengji; Sutter, Kathrin; Dittmer, Ulf; Chen, Jieliang; Yuan, Zhenghong
    Hepatitis B virus sensitivity to interferon-α in hepatocytes is more associated with cellular interferon response than with viral genotype
    In: Hepatology Vol. 67 (2018) Nr. 4, pp. 1237 - 1252
    ISSN: 1527-3350; 0270-9139
    Online Full Text: dx.doi.org/ (Open Access)
  • Korth, Johannes; Anastasiou, Olympia E.; Verheyen, Jens; Dickow, Julia; Sertznig, Helene; Frericks, Nicola; Bleekmann, Barbara; Kribben, Andreas; Brinkhoff, Alexandra; Wilde, Benjamin; Sutter, Kathrin; Dittmer, Ulf; Ciesek, Sandra; Witzke, Oliver; Widera, Marek
    Impact of immune suppressive agents on the BK-Polyomavirus non coding control region
    In: Antiviral Research Vol. 159 (2018) pp. 68 - 76
    ISSN: 1872-9096; 0166-3542
    Online Full Text: dx.doi.org/
  • Lavender, Kerry J.; Pace, Craig; Sutter, Kathrin; Messer, Ronald J.; Pouncey, Dakota L.; Cummins, Nathan W.; Natesampillai, Sekar; Zheng, Jim; Goldsmith, Joshua; Widera, Marek; Van Dis, Erik S.; Phillips, Katie; Race, Brent; Dittmer, Ulf; Kukolj, George; Hasenkrug, Kim J.
    An advanced BLT-humanized mouse model for extended HIV-1 cure studies
    In: AIDS Vol. 32 (2018) Nr. 1, pp. 1 - 10
    ISSN: 0269-9370; 1473-5571
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Knuschke, Torben; Rotan, Olga; Bayer, Wibke; Kollenda, Sebastian; Dickow, Julia; Sutter, Kathrin; Hansen, Wiebke; Dittmer, Ulf; Lang, Karl S.; Epple, Matthias; Buer, Jan; Westendorf, Astrid
    Induction of Type I Interferons by Therapeutic Nanoparticle-Based Vaccination Is Indispensable to Reinforce Cytotoxic CD8+ T Cell Responses During Chronic Retroviral Infection
    In: Frontiers in Immunology Vol. 9 (2018)
    ISSN: 1664-3224
    Online Full Text: dx.doi.org/ (Open Access)
  • Sutter, Kathrin; Dickow, Julia; Dittmer, Ulf
    Interferon α subtypes in HIV infection
    In: Cytokine & Growth Factor Reviews Vol. 40 (2018) pp. 13 - 18
    ISSN: 1359-6101; 1359-6101
    Online Full Text: dx.doi.org/

2017

  • Zhou, Yun; Li, Sheng; Tang, Zongsheng; Xu, Chunli; Huang, Shunmei; Wu, Jun; Dittmer, Ulf; Dickow, Julia; Sutter, Kathrin; Lu, Mengji; Yang, Dongliang; Song, Jingjiao
    Different antiviral effects of IFNα and IFNβ in an HBV mouse model
    In: Immunobiology Vol. 222 (2017) Nr. 3, pp. 562 - 570
    ISSN: 1878-3279; 0171-2985
    Online Full Text: dx.doi.org/
  • Malyshkina, Anna; Littwitz-Salomon, Elisabeth; Sutter, Kathrin; Zelinskyy, Gennadiy; Windmann, Sonja; Schimmer, Simone; Paschen, Annette; Streeck, Hendrik; Hasenkrug, Kim J; Dittmer, Ulf
    Fas Ligand-mediated cytotoxicity of CD4+ T cells during chronic retrovirus infection
    In: Scientific Reports Vol. 7 (2017) pp. 7785
    ISSN: 2045-2322
    Online Full Text: dx.doi.org/ (Open Access)
  • Li, Yanpeng; Sun, Binlian; Esser, Stefan; Jessen, Heiko; Streeck, Hendrik; Widera, Marek; Yang, Rongge; Dittmer, Ulf; Sutter, Kathrin
    Expression pattern of individual IFNA subtypes in chronic HIV infection
    In: Journal of Interferon & Cytokine Research Vol. 37 (2017) Nr. 12, pp. 541 - 549
    ISSN: 1079-9907; 1557-7465
    Online Full Text: dx.doi.org/
  • M. Ziegler, Susanne; Beisel, Claudia; Sutter, Kathrin; Griesbeck, Morgane; Hildebrandt, Heike; H. Hagen, Sven; Dittmer, Ulf; Altfeld, Marcus
    Human pDCs display sex-specific differences in type I interferon subtypes and interferon α/β receptor expression
    In: European Journal of Immunology Vol. 47 (2017) Nr. 2, pp. 251 - 256
    ISSN: 1521-4141; 0014-2980
    Online Full Text: dx.doi.org/
  • Song, Jingjiao; Li, Sheng; Zhou, Yun; Liu, Jia; Francois, Sandra; Lu, Mengji; Yang, Dongliang; Dittmer, Ulf; Sutter, Kathrin
    Different antiviral effects of IFNα subtypes in a mouse model of HBV infection
    In: Scientific Reports Vol. 7 (2017) Nr. 1, pp. 334
    ISSN: 2045-2322
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Schreiber, Timm; Quinting, Theresa; Dittmer, Ulf; Fandrey, Joachim; Sutter, Kathrin
    Hypoxia-inducible factor 1α is essential for macrophage-mediated erythroblast proliferation in acute friend retrovirus infection
    In: Scientific Reports Vol. 7 (2017) art. no. 17236
    ISSN: 2045-2322
    Online Full Text: dx.doi.org/ (Open Access)

 

2016

  • Blömker, Dominique; Mollérus, Sina; Gibbert, Kathrin; Dittmer, Ulf; Del Rey, Adriana E.; Schedlowski, Manfred; Engler, Harald
    Inhibition of catecholamine degradation ameliorates while chemical sympathectomy aggravates the severity of acute Friend retrovirus infection in mice
    In: Brain, Behavior and Immunity Vol. 54 (2016) pp. 252 - 259
    ISSN: 1090-2139; 0889-1591
    Online Full Text: dx.doi.org/
  • Littwitz-Salomon, Elisabeth; Dittmer, Ulf; Sutter, Kathrin
    Insufficient natural killer cell responses against retroviruses : How to improve NK cell killing of retrovirus-infected cells
    In: Retrovirology Vol. 13 (2016) Nr. 1, ISSN: 1742-4690
    Online Full Text: dx.doi.org/ (Open Access)
  • Lavender, Kerry J.; Gibbert, Kathrin; Peterson, Karin E.; Van Dis, Erik; Francois, Sandra; Woods, Tyson; Messer, Ronald J.; Gawanbacht, Ali; Müller, Janis A.; Münch, Jan; Phillips, Katie; Race, Brent; Harper, Michael S.; Guo, Kejun; Lee, Eric J.; Trilling, Mirko; Hengel, Hartmut; Piehler, Jacob; Verheyen, Jens; Wilson, Cara C.; Santiago, Mario L.; Hasenkrug, Kim J.; Dittmer, Ulf
    Interferon alpha subtype-specific suppression of HIV-1 infection in vivo
    In: Journal of Virology Vol. 90 (2016) Nr. 13, pp. 6001 - 6013
    ISSN: 1098-5514; 0022-538X
    Online Full Text: dx.doi.org/ (Open Access)

2015

Wu, Weimin; Dietze, Kirsten; Gibbert, Kathrin; Lang, Karl S.; Trilling, Mirko; Yan, Huimin; Wu, Jun; Yang, Dongliang; Lu, Mengji; Roggendorf, Michael; Dittmer, Ulf; Liu, Jia
TLR ligand induced IL-6 counter-regulates the anti-viral CD8+ T cell response during an acute retrovirus infection
In: Scientific Reports Vol. 5 (2015) pp. 10501
ISSN: 2045-2322
Online Full Text: dx.doi.org/ Online Full Text (Open Access)

2014

Bröring, Ruth; Real, Catherine; John, Matthias J.; Jahn-Hofmann, Kerstin; Ickenstein, Ludger M.; Kleinehr, Kathrin; Paul, Andreas; Sutter, Kathrin; Dittmer, Ulf; Gerken, Guido; Schlaak, Jörg Friedrich
Chemical modifications on siRNAs avoid Toll-like-receptor-mediated activation of the hepatic immune system in vivo and in vitro
In: International Immunology Vol. 26 (2014) Nr. 1, pp. 35 - 46
ISSN: 0953-8178; 1460-2377
Online Full Text: dx.doi.org/

  • 2023

     

    2022

     

    2021

    • Wang, Shichuan; Trilling, Mirko; Sutter, Kathrin; Dittmer, Ulf; Lu, Mengji; Zheng, Xin; Yang, Dongliang; Liu, Jia
      A Crowned Killer’s Résumé : Genome, Structure, Receptors, and Origin of SARS-CoV-2
      In: Virologica Sinica (2020)
      ISSN: 1995-820X; 1674-0769
      Online Full Text: dx.doi.org/ (Open Access)

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