AG Kathrin Sutter

Forschungsschwerpunkte

  • Typ I Interferone: Immunmodulation und antivirale Therapie
  • Interferon-alpha Subtypen
  • Modulation von Immunzellen
  • Immuntherapien
  • chronische Virusinfektionen (HIV, HBV)
  • IFN-stimulierte Gene
  • NK-Zellen 

Projekt

Während den meisten Virusinfektionen ist die erste Immunantwort charakterisiert durch die Induktion von Typ I Interferon (IFN). IFN gehört zu einer Genfamilie, welche bis zu 13 verschiedene IFN-α Subtypen und IFN-β mit einschließt. Diese Interferone weisen alle unterschiedliche biologische Aktivitäten auf wie z.B. antivirale, anti-proliferative und immunmodulatorische Eigenschaften. Nach ihrer Induktion, binden alle Interferone an den gleichen Rezeptor, was zu der Expression zahlreicher verschiedener IFN-stimulierter Gene führt, welche für antivirale Proteine kodieren, die direkt die virale Replikation inhibieren wie auch die Funktion von Immunzellen modulieren. Daher ist die Induktion von Typ I IFN ein wirkungsvolles Mittel gegen Virusinfektionen anzukämpfen. Viele Viren haben Wege gefunden der IFN-Antwort zu entgehen. Deshalb sollte die therapeutische Gabe von exogenem Typ I IFN ein großes Potential für zukünftige Immuntherapien gegen Virusinfektionen besitzen. Die Arbeitsgruppe ist hauptsächlich interessiert an den verschiedenen antiviralen und immunmodulatorischen Eigenschaften aller humanen und murinen IFN-α Subtypen in akuten und chronischen Virusinfektionen. Ein besonderer Augenmerk liegt auf der Induktion der verschiedenen Subtypen, deren Regulation und ihren erschiedenen biologischen Eigenschaften besonders die Modulation von Immunantworten. 

During most viral infections, the immediate host response is characterized by an induction of type I Interferon (IFN). IFN belongs to a multigene family that includes up to 13 different IFN-α subtypes and IFN-β, which have various biological activities, including anti-viral, anti-proliferative and immunomodulatory effects. After induction, they all bind to the same receptor, which results in the expression of numerous different IFN-stimulated genes which encode anti-viral proteins that directly inhibit viral replication as well as modulate immune function. Thus, the induction of type I IFN is a very powerful tool for the host to fight virus infections. Many viruses evade this response by various strategies. Therefore, the therapeutic application of exogenous type I IFN should be of great potential for future immunotherapies against viral infections. The research group is mainly focusing on the various antiviral and immunomodulatory activities of the different human and murine IFN-α subtypes in acute and chronic viral infections. We are interested in the induction of the subtypes, their regulation and their different biological activities especially the modulation of immune responses.

Arbeitsgruppe

group leader

Kathrin Sutter

PD Dr. rer nat. Kathrin Sutter (geb. Gibbert)
kathrin.sutter@uni-due.de
0201-723-83250

PhD Student

B. Sc. Mara Schwerdtfeger
Raum 2.051
0201-723-4050
mara.schwerdtfeger@uk-essen.de

PhD Student

M. Sc. Zehra Karaköse
Raum 2.051
0201-723-4224
zehra.karakoese@uk-essen.de

Bachelor Student

Julia Boesner
Raum 2.051
0201-723-4050

(MTA)

Sandra Francois
Raum 2.061
0201-723-83737
Sandra.francois@uk-essen.de

Publikationen

    2025

    Artikel in Zeitschriften

  • Shahhamzehei, Nasim; Abdelfatah, Sara; Omer, Ejlal A.; Riedl, Max; Meesters, Christian; Schwarzer-Sperber, Hannah S.; Sutter, Kathrin; Bringmann, Gerhard; Schwarzer, Roland; Efferth, Thomas
    Diketopiperazine/piperidine alkaloid as a potential broad-spectrum coronaviral entry inhibitor identified by supercomputer-based virtual screening from a large natural product-based library
    In: Biomedicine & Pharmacotherapy Jg. 183 (2025) 117841
  • Zhu, Dan; Du, Yanqin; Zhao, Mengxiao; Ablikim, Dilhumare; Huang, Hongming; Pan, Wen; Zeng, Xiaoqing; Xu, Chunli; Lu, Mengji; Sutter, Kathrin; Dittmer, Ulf; Zheng, Xin; Yang, Dongliang; Liu, Jia
    Functional B cell deficiency promotes intrahepatic HBV replication and impairs the development of anti-HBV T cell responses
    In: Hepatology International Jg. 19 (2025) Nr. 1, S. 93 - 105
  • Schimmer, Simone; Sridhar, Vaasudevan; Satan, Zelal; Grebe, Anton; Saad, Mohamed; Wagner, Bernd; Kahlert, Nele; Werner, Tanja; Richter, Dana; Dittmer, Ulf; Sutter, Kathrin; Littwitz-Salomon, Elisabeth
    Iron improves the antiviral activity of NK cells
    In: Frontiers in Immunology Jg. 15 (2025) 1526197
  • 2024

    Artikel in Zeitschriften

  • Kühn, Daniel; Heinen, Natalie; Sutter, Kathrin; Herrmann, Simon T.; Nocke, Maximilian K.; Todt, Daniel; Burbelo, Peter D.; Steinmann, Eike; Ziehe, Dominik; Koos, Björn; Adamzik, Michael; Putensen, Christian; Zarbock, Alexander; Gravemann, Ute; Jork, Christine; Pfaender, Stephanie
    Divergent autoantibody and cytokine levels in COVID-19 sepsis patients influence survival
    In: Journal of Medical Virology Jg. 96 (2024) Nr. 10, e29935
  • Karakoese, Zehra; Ingola, Martha; Sitek, Barbara; Dittmer, Ulf; Sutter, Kathrin
    IFNα Subtypes in HIV Infection and Immunity
    In: Viruses Jg. 16 (2024) Nr. 3, 364
  • Shahhamzehei, Nasim; Abdelfatah, Sara; Schwarzer-Sperber, Hannah S.; Sutter, Kathrin; Yücer, Rümeysa; Bringmann, Gerhard; Schwarzer, Roland; Efferth, Thomas
    Identification of nitrile-containing isoquinoline-related natural product derivatives as coronavirus entry inhibitors in silico and in vitro
    In: Biomedicine & Pharmacotherapy Jg. 180 (2024) 117517
  • Steinbach, Philine; Pastille, Eva; Kaumanns, Lara; Adamczyk, Alexandra; Sutter, Kathrin; Hansen, Wiebke; Dittmer, Ulf; Buer, Jan; Westendorf, Astrid M.; Knuschke, Torben
    Influenza virus infection enhances tumour-specific CD8+ T-cell immunity, facilitating tumour control
    In: PLoS Pathogens Jg. 20 (2024) Nr. 1, e1011982
  • Albanese, Manuel; Chen, Hong-Ru; Gapp, Madeleine; Muenchhoff, Maximilian; Yang, Hsiu-Hui; Peterhoff, David; Hoffmann, Katja; Xiao, Qianhao; Ruhle, Adrian; Ambiel, Ina; Schneider, Stephanie; Mejías-Pérez, Ernesto; Stern, Marcel; Wratil, Paul R.; Hofmann, Katharina; Amann, Laura; Jocham, Linda; Fuchs, Thimo; Ulivi, Alessandro F.; Besson-Girard, Simon; Weidlich, Simon; Schneider, Jochen; Spinner, Christoph D.; Sutter, Kathrin; Dittmer, Ulf; Humpe, Andreas; Baumeister, Philipp; Wieser, Andreas; Rothenfusser, Simon; Bogner, Johannes; Roider, Julia; Knolle, Percy; Hengel, Hartmut; Wagner, Ralf; Laketa, Vibor; Fackler, Oliver T.; Keppler, Oliver T.
    Receptor transfer between immune cells by autoantibody-enhanced, CD32-driven trogocytosis is hijacked by HIV-1 to infect resting CD4 T cells
    In: Cell Reports Medicine Jg. 5 (2024) Nr. 4, 101483
  • Schreiber, Timm; Koll, Nora; Padberg, Claudia; de los Reyes, Buena; Quinting, Theresa; Malyshkina, Anna; Metzen, Eric; Sutter, Kathrin; Fandrey, Joachim; Winning, Sandra
    Reduced vacuolar ATPase protects mice from Friend virus infection : An unintended but instructive effect in Hif-2afl mice
    In: Journal of Cell Science Jg. 137 (2024) Nr. 12, jcs261893
  • Roesmann, Fabian; Sertznig, Helene; Klaassen, Katleen; Wilhelm, Alexander; Heininger, Delia; Heß, Stefanie; Elsner, Carina; Marschalek, Rolf; Santiago, Mario L.; Esser, Stefan; Sutter, Kathrin; Dittmer, Ulf; Widera, Marek
    The interferon-regulated host factor hnRNPA0 modulates HIV-1 production by interference with LTR activity, mRNA trafficking, and programmed ribosomal frameshifting
    In: Journal of Virology Jg. 98 (2024) Nr. 7, e0053424
  • 2023

    Artikel in Zeitschriften

  • Wang, Qin; Liu, Yanan; Luo, Jinzhuo; Yang, Shangqing; Wang, Lu; Lu, Yinping; Feng, Xuemei; Yang, Xuecheng; Sutter, Kathrin; Dittmer, Ulf; Lu, Mengji; Zheng, Xin; Yang, Dongliang; Liu, Jia
    A systematic comparison reveals dynamic differences in early adaptive immune responses of acute-resolving versus chronic HBV replication
    In: Journal of Medical Virology Jg. 95 (2023) Nr. 3, e28670
  • Malyshkina, Anna; Bayer, Wibke; Podschwadt, Philip; Otto, Lucas; Karakoese, Zehra; Sutter, Kathrin; Bruderek, Kirsten; Wang, Baoxiao; Lavender, Kerry J.; Santiago, Mario L.; Leipe, Pia Madeleine; Elsner, Carina; Esser, Stefan; Brandau, Sven; Gunzer, Matthias; Dittmer, Ulf
    Immunotherapy-induced cytotoxic T follicular helper cells reduce numbers of retrovirus-infected reservoir cells in B cell follicles
    In: PLoS Pathogens Jg. 19 (2023) Nr. 10, e1011725
  • Westmeier, Jaana; Brochtrup, Annika; Paniskaki, Krystallenia; Karakoese, Zehra; Werner, Tanja; Sutter, Kathrin; Dolff, Sebastian; Limmer, Andreas; Mittermüller, Daniela; Liu, Jia; Zheng, Xin; Koval, Tetiana; Kaidashev, Igor; Berger, Marc Moritz; Herbstreit, Frank; Brenner, Thorsten; Witzke, Oliver; Trilling, Mirko; Lu, Mengji; Yang, Dongliang; Babel, Nina; Westhoff, Timm; Dittmer, Ulf; Zelinskyy, Gennadiy
    Macrophage migration inhibitory factor receptor CD74 expression is associated with expansion and differentiation of effector T cells in COVID-19 patients
    In: Frontiers in Immunology Jg. 14 (2023) 1236374
  • Li, Ziwei; Xiang, Tiandan; Liang, Boyun; Liu, Jing; Deng, Hui; Yang, Xuecheng; Wang, Hua; Feng, Xuemei; Zelinskyy, Gennadiy; Trilling, Mirko; Sutter, Kathrin; Lu, Mengji; Dittmer, Ulf; Wang, Baoju; Yang, Dongliang; Zheng, Xin; Liu, Jia
    SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection
    In: Virologica Sinica Jg. 38 (2023) Nr. 4, S. 606 - 619
  • Karakoese, Zehra; Le-Trilling, Vu Thuy Khanh; Schuhenn, Jonas; Francois, Sandra; Lu, Mengji; Liu, Jia; Trilling, Mirko; Hoffmann, Daniel; Dittmer, Ulf; Sutter, Kathrin
    Targeted mutations in IFNα2 improve its antiviral activity against various viruses
    In: mBio Jg. 14 (2023) Nr. 6, e02357-23
  • Schefczyk, Stefan; Luo, Xufeng; Liang, Yaojie; Hasenberg, Mike; Walkenfort, Bernd; Trippler, Martin; Schuhenn, Jonas; Sutter, Kathrin; Lu, Mengji; Wedemeyer, Heiner; Schmidt, Hartmut H.; Broering, Ruth
    Tg1.4HBV-s-rec mice, a crossbred hepatitis B virus-transgenic model, develop mild hepatitis
    In: Scientific Reports Jg. 13 (2023) Nr. 1, 22829
  • Abstracts

  • Karakoese, Zehra; Schwerdtfeger, Mara; Karsten, Christina; Esser, Stefan; Dittmer, Ulf; Sutter, Kathrin;
    Distinct type I interferon subtypes differentially stimulate T cell responses in HIV1-infected individuals
    DÖAK 2023 / German-Austrian AIDS Conference, Bonn, Germany, 23-25 March 2023,
    In: HIV Medicine Jg. 24 (2023) Nr. 1, S. 92
  • Kruth, Carolin; Schwarzer-Sperber, Hannah; Esser, Stefan; Dittmer, Ulf; Schwarzer, Roland; Sutter, Kathrin;
    Effects of type I interferons on HIV latency
    DÖAK 2023 / German-Austrian AIDS Conference, Bonn, Germany, 23-25 March 2023,
    In: HIV Medicine Jg. 24 (2023) Nr. S1, S. 82
  • Poster / Posterbeiträge

  • Steinbach, Philine; Sutter, Kathrin; Westendorf, Astrid; Buer, Jan; Knuschke, Torben;
    Respiratory but not systemic viral infection induces tumour growth inhibition through CD8+T-cell activation
    Joint Conference of the Société Française d'Immunologie (SFI) and the Deutsche Gesellschaft für Immunologie (DGfI) ; 26-29 September, 2023, Strasbourg, France,
    In: European Journal of Immunology Jg. 53 (2023) Nr. S2, Special issue: Abstracts: Joint Conference of the Société Française d'Immunologie (SFI) and the Deutsche Gesellschaft für Immunologie (DGfI), 26–29 September, 2023, Strasbourg, France, S. 189
  • 2022

    Artikel in Zeitschriften

  • Meister, Toni Luise; Brüggemann, Yannick; Nocke, Maximilian K.; Ulrich, Rainer G.; Schuhenn, Jonas; Sutter, Kathrin; Gömer, André; Bader, Verian; Winklhofer, Konstanze F.; Bröring, Ruth; Verhoye, Lieven; Meuleman, Philip; Vondran, Florian W. R.; Camuzet, Charline; Cocquerel, Laurence; Todt, Daniel; Steinmann, Eike
    A ribavirin-induced ORF2 single-nucleotide variant produces defective hepatitis E virus particles with immune decoy function
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Jg. 119 (2022) Nr. 34, e2202653119
  • Wenzek, Christina; Steinbach, Philine; Wirsdörfer, Florian; Sutter, Kathrin; Boehme, Julia D.; Geffers, Robert; Klopfleisch, Robert; Bruder, Dunja; Jendrossek, Verena; Buer, Jan; Westendorf, Astrid; Knuschke, Torben
    CD47 restricts antiviral function of alveolar macrophages during influenza virus infection
    In: iScience Jg. 25 (2022) Nr. 12, 105540
  • Schuhenn, Jonas; Meister, Toni Luise; Todt, Daniel; Bracht, Thilo; Schork, Karin; Billaud, Jean-Noel; Elsner, Carina; Heinen, Natalie; Karakoese, Zehra; Haid, Sibylle; Kumar, Sriram; Brunotte, Linda; Eisenacher, Martin; Di, Yunyun; Lew, Jocelyne; Falzarano, Darryl; Chen, Jieliang; Yuan, Zhenghong; Pietschmann, Thomas; Wiegmann, Bettina; Uebner, Hendrik; Taube, Christian; Le-Trilling, Vu Thuy Khanh; Trilling, Mirko; Krawczyk, Adalbert; Ludwig, Stephan; Sitek, Barbara; Steinmann, Eike; Dittmer, Ulf; Lavender, Kerry J.; Sutter, Kathrin; Pfaender, Stephanie
    Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Jg. 119 (2022) Nr. 8, e2111600119
  • Karakoese, Zehra; Schwerdtfeger, Mara; Karsten, Christina; Esser, Stefan; Dittmer, Ulf; Sutter, Kathrin
    Distinct Type I Interferon Subtypes Differentially Stimulate T Cell Responses in HIV-1-Infected Individuals
    In: Frontiers in Immunology Jg. 13 (2022) 936918
  • Rout, Saurav S.; Di, Yunyun; Dittmer, Ulf; Sutter, Kathrin; Lavender, Kerry J.
    Distinct effects of treatment with two different interferon-alpha subtypes on HIV-1-associated T-cell activation and dysfunction in humanized mice
    In: AIDS Jg. 36 (2022) Nr. 3, S. 325 - 336
  • Hussain, Timon; Domnich, Maksim; Bordbari, Sharareh; Pylaeva, Ekaterina; Siakaeva, Elena; Spyra, Ilona; Ozel, Irem; Droege, Freya; Squire, Anthony; Lienenklaus, Stefan; Sutter, Kathrin; Hasenberg, Anja; Gunzer, Matthias; Lang, Stephan; Jablonska, Jadwiga
    IFNAR1 Deficiency Impairs Immunostimulatory Properties of Neutrophils in Tumor-Draining Lymph Nodes
    In: Frontiers in Immunology Jg. 13 (2022)
  • Xie, Xiaohong; Karakoese, Zehra; Ablikim, Dilhumare; Ickler, Julia; Schuhenn, Jonas; Zeng, Xiaoqing; Feng, Xuemei; Yang, Xuecheng; Dittmer, Ulf; Yang, Dongliang; Sutter, Kathrin; Liu, Jia
    IFNα subtype-specific susceptibility of HBV in the course of chronic infection
    In: Frontiers in Immunology Jg. 13 (2022) 1017753
  • Schwerdtfeger, Mara; Dickow, Julia; Schmitz, Yasmin; Francois, Sandra; Karakoese, Zehra; Malyshkina, Anna; Knuschke, Torben; Dittmer, Ulf; Sutter, Kathrin
    Immunotherapy With Interferon α11, But Not Interferon Beta, Controls Persistent Retroviral Infection
    In: Frontiers in Immunology Jg. 12 (2022) 809774
  • Sertznig, Helene; Roesmann, Fabian; Wilhelm, Alexander; Heininger, Delia; Bleekmann, Barbara; Elsner, Carina; Santiago, Mario; Schuhenn, Jonas; Karakoese, Zehra; Benatzy, Yvonne; Snodgrass, Ryan; Esser, Stefan; Sutter, Kathrin; Dittmer, Ulf; Widera, Marek
    SRSF1 acts as an IFN-I-regulated cellular dependency factor decisively affecting HIV-1 post-integration steps
    In: Frontiers in Immunology Jg. 13 (2022) 935800
  • Schmitz, Yasmin; Schwerdtfeger, Mara; Westmeier, Jaana; Littwitz-Salomon, Elisabeth; Alt, Mira; Brochhagen, Leonie; Krawczyk, Adalbert; Sutter, Kathrin
    Superior antiviral activity of IFNβ in genital HSV-1 infection
    In: Frontiers in Cellular and Infection Microbiology Jg. 12 (2022) 949036
  • Sperber, Hannah Sabeth; Sutter, Kathrin; Müller, Karin; Müller, Peter; Schwarzer, Roland
    The Bovine Seminal Plasma Protein PDC-109 Possesses Pan-Antiviral Activity
    In: Viruses Jg. 14 (2022) Nr. 9, 2031
  • David, Paul; Westmeier, Jaana; Drabczyk-Pluta, Malgorzata; Werner, Tanja; Ickler, Julia; Francois, Sandra; Bayer, Wibke; Sutter, Kathrin; Del Rio, Maria Luisa; Rodriguez-Barbosa, Jose-Ignacio; Dittmer, Ulf; Zelinskyy, Gennadiy
    The Role of the Inhibitory Ligand HVEM and Its Receptors CD160 and BTLA in the Regulation of Anti-retroviral T Cell Responses
    In: Frontiers in Virology Jg. 2 (2022) 836291
  • 2021

    Artikel in Zeitschriften

  • Liu, Jia; Yang, Xuecheng; Wang, Hua; Li, Ziwei; Deng, Hui; Liu, Jing; Xiong, Shue; He, Junyi; Feng, Xuemei; Guo, Chunxia; Wang, Weixian; Zelinskyy, Gennadiy; Trilling, Mirko; Sutter, Kathrin; Senff, Tina; Menne, Christopher; Timm, Jörg; Zhang, Yanfang; Deng, Fei; Lu, Yinping; Wu, Jun; Lu, Mengji; Yang, Dongliang; Dittmer, Ulf; Wang, Baoju; Zheng, Xin
    Analysis of the long-term impact on cellular immunity in COVID-19-recovered individuals reveals a profound nkt cell impairment
    In: mBio Jg. 12 (2021) Nr. 2, S. e00085 - 21
  • Li, Ziwei; Xiang, Tiandan; Liang, Boyun; Deng, Hui; Wang, Hua; Feng, Xuemei; Quan, Xufeng; Wang, Xiaoyan; Li, Sumeng; Lu, Sihong; Yang, Xuecheng; Wang, Baoju; Zelinskyy, Gennadiy; Trilling, Mirko; Sutter, Kathrin; Lu, Mengji; Dittmer, Ulf; Yang, Dongliang; Zheng, Xin; Liu, Jia
    Characterization of SARS-CoV-2-Specific Humoral and Cellular Immune Responses Induced by Inactivated COVID-19 Vaccines in a Real-World Setting
    In: Frontiers in Immunology Jg. 12 (2021) 802858
  • Chen, Jieliang; Li, Yaming; Lai, Fritz; Wang, Yang; Sutter, Kathrin; Dittmer, Ulf; Ye, Jianyu; Zai, Wenjing; Liu, Min; Shen, Fang; Wu, Min; Hu, Kongying; Li, Baocun; Lu, Mengji; Zhang, Xiaonan; Zhang, Jiming; Li, Jianhua; Chen, Qingfeng; Yuan, Zhenghong
    Functional Comparison of Interferon-α Subtypes Reveals Potent Hepatitis B Virus Suppression by a Concerted Action of Interferon-α and Interferon-γ Signaling
    In: Hepatology Jg. 73 (2021) Nr. 2, S. 486 - 502
  • Xiong, Shue; Zhu, Dan; Liang, Boyun; Li, Mingyue; Pan, Wen; He, Junyi; Wang, Hua; Sutter, Kathrin; Dittmer, Ulf; Lu, Mengji; Liu, Di; Yang, Dongliang; Liu, Jia; Zheng, Xin
    Longitudinal characterization of phenotypic profile of T cells in chronic hepatitis B identifies immune markers associated with HBsAg loss
    In: eBioMedicine Jg. 69 (2021) 103464
  • Wienhöfer, Lisa; Marker, Max; Antoni, Anne-Charlotte; Sutter, Kathrin; Sander, André; Dudda, Marcel; Flohe, Stefanie
    TLR4 Transactivates CD8⁺ T Lymphocytes upon Acute Sterile Tissue Injury
    In: ImmunoHorizons Jg. 5 (2021) Nr. 5, S. 298 - 306
  • 2020

    Artikel in Zeitschriften

  • Wang, Shichuan; Trilling, Mirko; Sutter, Kathrin; Dittmer, Ulf; Lu, Mengji; Zheng, Xin; Yang, Dongliang; Liu, Jia
    A Crowned Killer’s Résumé : Genome, Structure, Receptors, and Origin of SARS-CoV-2
    In: Virologica Sinica (2020)
  • Sutter, Kathrin
    Die Einmischer: Interferone : Wie sie die Immunantwort beeinflussen, um Viren effektiv zu bekämpfen
    In: Unikate: Berichte aus Forschung und Lehre (2020) Nr. 54: Medizin: Infektionskrankheiten - ein globales Problem, S. 18 - 27
  • Westmeier, Jaana; Paniskaki, Krystallenia; Karaköse, Zehra; Werner, Tanja; Sutter, Kathrin; Dolff, Sebastian; Overbeck, Marvin; Limmer, Andreas; Liu, Jia; Zheng, Xin; Brenner, Thorsten; Berger, Marc; Witzke, Oliver; Trilling, Mirko; Lu, Mengji; Yang, Dongliang; Babel, Nina; Westhoff, Timm; Dittmer, Ulf; Zelinskyy, Gennadiy
    Erratum for Westmeier et al., "Impaired Cytotoxic CD8⁺ T Cell Response in Elderly COVID-19 Patients"
    In: mBio Jg. 11 (2020) Nr. 5, S. 02243 - 02220
  • Ickler, Julia; Francois, Sandra; Widera, Marek; Santiago, Mario L.; Dittmer, Ulf; Sutter, Kathrin
    HIV infection does not alter interferon α/β receptor 2 expression on mucosal immune cells
    In: PLoS ONE Jg. 15 (2020) Nr. 1, S. e0218905
  • Westmeier, Jaana; Paniskaki, Krystallenia; Karaköse, Zehra; Werner, Tanja; Sutter, Kathrin; Dolff, Sebastian; Overbeck, Marvin; Limmer, Andreas; Liu, Jia; Zheng, Xin; Brenner, Thorsten; Berger, Marc; Witzke, Oliver; Trilling, Mirko; Lu, Mengji; Yang, Dongliang; Babel, Nina; Westhoff, Timm; Dittmer, Ulf; Zelinskyy, Gennadiy
    Impaired cytotoxic CD8⁺ T cell response in elderly COVID-19 patients
    In: mBio Jg. 11 (2020) Nr. 5, S. e02243 - 20
  • Liu, Jia; Zheng, Xin; Tong, Qiaoxia; Li, Wei; Wang, Baoju; Sutter, Kathrin; Trilling, Mirko; Lu, Mengji; Dittmer, Ulf; Yang, Dongliang
    Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV
    In: Journal of Medical Virology Jg. 92 (2020) Nr. 5, S. 491 - 494
  • Guo, Kejun; Shen, Guannan; Kibbie, Jon; Gonzalez, Tania; Dillon, Stephanie M.; Smith, Harry A.; Cooper, Emily H.; Lavender, Kerry; Hasenkrug, Kim J.; Sutter, Kathrin; Dittmer, Ulf; Kroehl, Miranda; Kechris, Katerina; Wilson, Cara C.; Santiago, Mario L.
    Qualitative differences between the IFNα subtypes and IFNβ influence chronic mucosal HIV-1 pathogenesis
    In: PLoS Pathogens Jg. 16 (2020) Nr. 10, S. 1008986
  • Zutz, Ariane; Schölz, Christian; Schneider, Stephanie; Pierini, Virginia; Münchhoff, Maximilian; Sutter, Kathrin; Wittmann, Georg; Dittmer, Ulf; Draenert, Rika; Bogner, Johannes R.; Fackler, Oliver T.; Keppler, Oliver T.
    SERINC5 Is an Unconventional HIV Restriction Factor That Is Upregulated during Myeloid Cell Differentiation
    In: Journal of Innate Immunity Jg. 12 (2020) Nr. 5, S. 399 - 409
  • Heilingloh, Christiane Silke; Aufderhorst, Ulrich Wilhelm; Schipper, Leonie; Dittmer, Ulf; Witzke, Oliver; Yang, Dongliang; Zheng, Xin; Sutter, Kathrin; Trilling, Mirko; Alt, Mira; Steinmann, Eike; Krawczyk, Adalbert
    Susceptibility of SARS-CoV-2 to UV irradiation
    In: American Journal of Infection Control Jg. 48 (2020) Nr. 10, S. 1273 - 1275
  • 2019

    Artikel in Zeitschriften

  • Matos, Aline da Rocha; Wunderlich, Katharina; Schloer, Sebastian; Schughart, Klaus; Geffers, Robert; Seders, Martine; Witt, Marlous de; Christersson, Anmari; Wiewrodt, Rainer; Wiebe, Karsten; Barth, Peter; Hocke, Andreas; Hippenstiel, Stefan; Hönzke, Katja; Dittmer, Ulf; Sutter, Kathrin; Rescher, Ursula; Rodionycheva, Svetlana; Matera, Nicoletta; Ludwig, Stephan; Brunotte, Linda
    Antiviral potential of human IFN-α subtypes against influenza A H3N2 infection in human lung explants reveals subtype-specific activities
    In: Emerging Microbes & Infections Jg. 8 (2019) Nr. 1, S. 1763 - 1776
  • Passos, Vânia; Zillinger, Thomas; Casartelli, Nicoletta; Wachs, Amelie S.; Xu, Shuting; Malassa, Angelina; Steppich, Katja; Schilling, Hildegard; Franz, Sergej; Todt, Daniel; Steinmann, Eike; Sutter, Kathrin; Dittmer, Ulf; Bohne, Jens; Schwartz, Olivier; Barchet, Winfried; Goffinet, Christine
    Characterization of Endogenous SERINC5 Protein as Anti-HIV-1 Factor
    In: Journal of Virology Jg. 93 (2019) Nr. 24, S. e01221 - 19
  • Malyshkina, Anna; Littwitz-Salomon, Elisabeth; Sutter, Kathrin; Ross, Jean Alexander; Paschen, Annette; Windmann, Sonja; Schimmer, Simone; Dittmer, Ulf
    Chronic retroviral infection of mice promotes tumor development, but CD137 agonist therapy restores effective tumor immune surveillance
    In: Cancer Immunology, Immunotherapy Jg. 68 (2019) Nr. 3, S. 479 - 488
  • Sutter, Kathrin; Lavender, Kerry J.; Messer, Ronald J.; Widera, Marek; Williams, Katie; Race, Brent; Hasenkrug, Kim J.; Dittmer, Ulf
    Concurrent administration of IFNα14 and cART in TKO-BLT mice enhances suppression of HIV-1 viremia but does not eliminate the latent reservoir
    In: Scientific Reports Jg. 9 (2019) S. 18089
  • Hasenkrug, Kim J.; Lavender, Kerry J.; Santiago, Mario L.; Sutter, Kathrin; Dittmer, Ulf
    Different Biological Activities of Specific Interferon Alpha Subtypes
    In: mSphere Jg. 4 (2019) Nr. 4, e00127 - 19
  • Dickow, Julia; Francois, Sandra; Kaiserling, Rouven-Luca; Malyshkina, Anna; Drexler, Ingo; Westendorf, Astrid Maria; Lang, Karl Sebastian; Santiago, Mario L.; Dittmer, Ulf; Sutter, Kathrin
    Diverse immunomodulatory effects of individual IFNα subtypes on virus-specific CD8⁺ T cell responses
    In: Frontiers in Immunology Jg. 10 (2019) 2255
  • Dittmer, Ulf; Sutter, Kathrin; Kassiotis, George; Zelinskyy, Gennadiy; Bánki, Zoltán; Stoiber, Heribert; Santiago, Mario L.; Hasenkrug, Kim J.
    Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity
    In: FEMS Microbiology Reviews Jg. 43 (2019) Nr. 5, S. 435 - 456
  • Braun, Elisabeth; Hotter, Dominik; Koepke, Lennart; Zech, Fabian; Groß, Rüdiger; Sparrer, Konstantin M.J.; Müller, Janis A.; Pfaller, Christian K.; Heusinger, Elena; Wombacher, Rebecka; Sutter, Kathrin; Dittmer, Ulf; Winkler, Michael; Simmons, Graham; Jakobsen, Martin R.; Conzelmann, Karl-Klaus; Pöhlmann, Stefan; Münch, Jan; Fackler, Oliver T.; Kirchhoff, Frank; Sauter, Daniel
    Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins
    In: Cell Reports Jg. 27 (2019) Nr. 7, S. 2092 - 2104.e10
  • Xia, Yuchen; Schlapschy, Martin; Morath, Volker; Roeder, Natalie; Vogt, Elisabeth I.; Stadler, Daniela; Cheng, Xiaoming; Dittmer, Ulf; Sutter, Kathrin; Heikenwalder, Mathias; Skerra, Arne; Protzer, Ulrike
    PASylated interferon α efficiently suppresses hepatitis B virus and induces anti-HBs seroconversion in HBV-transgenic mice
    In: Antiviral Research Jg. 161 (2019) S. 134 - 143
  • Gujer, Cornelia; Murer, Anita; Müller, Anne; Vanoaica, Danusia; Sutter, Kathrin; Jacque, Emilie; Fournier, Nathalie; Kalchschmidt, Jens; Zbinden, Andrea; Capaul, Riccarda; Dzionek, Andrzej; Mondon, Philippe; Dittmer, Ulf; Münz, Christian
    Plasmacytoid dendritic cells respond to Epstein-Barr virus infection with a distinct type I interferon subtype profile
    In: Blood Advances Jg. 3 (2019) Nr. 7, S. 1129 - 1144
  • 2018

    Artikel in Zeitschriften

  • Lavender, Kerry J.; Pace, Craig; Sutter, Kathrin; Messer, Ronald J.; Pouncey, Dakota L.; Cummins, Nathan W.; Natesampillai, Sekar; Zheng, Jim; Goldsmith, Joshua; Widera, Marek; Van Dis, Erik S.; Phillips, Katie; Race, Brent; Dittmer, Ulf; Kukolj, George; Hasenkrug, Kim J.
    An advanced BLT-humanized mouse model for extended HIV-1 cure studies
    In: AIDS Jg. 32 (2018) Nr. 1, S. 1 - 10
  • Shen, Fang; Li, Yaming; Wang, Yang; Sozzi, Vitina; Revill, Peter A.; Liu, Jiangxia; Gao, Lu; Yang, Guang; Lu, Mengji; Sutter, Kathrin; Dittmer, Ulf; Chen, Jieliang; Yuan, Zhenghong
    Hepatitis B virus sensitivity to interferon-α in hepatocytes is more associated with cellular interferon response than with viral genotype
    In: Hepatology Jg. 67 (2018) Nr. 4, S. 1237 - 1252
  • Korth, Johannes; Anastasiou, Olympia E.; Verheyen, Jens; Dickow, Julia; Sertznig, Helene; Frericks, Nicola; Bleekmann, Barbara; Kribben, Andreas; Brinkhoff, Alexandra; Wilde, Benjamin; Sutter, Kathrin; Dittmer, Ulf; Ciesek, Sandra; Witzke, Oliver; Widera, Marek
    Impact of immune suppressive agents on the BK-Polyomavirus non coding control region
    In: Antiviral Research Jg. 159 (2018) S. 68 - 76
  • Knuschke, Torben; Rotan, Olga; Bayer, Wibke; Kollenda, Sebastian; Dickow, Julia; Sutter, Kathrin; Hansen, Wiebke; Dittmer, Ulf; Lang, Karl S.; Epple, Matthias; Buer, Jan; Westendorf, Astrid
    Induction of Type I Interferons by Therapeutic Nanoparticle-Based Vaccination Is Indispensable to Reinforce Cytotoxic CD8+ T Cell Responses During Chronic Retroviral Infection
    In: Frontiers in Immunology Jg. 9 (2018) 614
  • Sutter, Kathrin; Dickow, Julia; Dittmer, Ulf
    Interferon α subtypes in HIV infection
    In: Cytokine & Growth Factor Reviews Jg. 40 (2018) S. 13 - 18
  • 2017

    Artikel in Zeitschriften

  • Zhou, Yun; Li, Sheng; Tang, Zongsheng; Xu, Chunli; Huang, Shunmei; Wu, Jun; Dittmer, Ulf; Dickow, Julia; Sutter, Kathrin; Lu, Mengji; Yang, Dongliang; Song, Jingjiao
    Different antiviral effects of IFNα and IFNβ in an HBV mouse model
    In: Immunobiology Jg. 222 (2017) Nr. 3, S. 562 - 570
  • Song, Jingjiao; Li, Sheng; Zhou, Yun; Liu, Jia; Francois, Sandra; Lu, Mengji; Yang, Dongliang; Dittmer, Ulf; Sutter, Kathrin
    Different antiviral effects of IFNα subtypes in a mouse model of HBV infection
    In: Scientific Reports Jg. 7 (2017) Nr. 1, S. 334
  • Li, Yanpeng; Sun, Binlian; Esser, Stefan; Jessen, Heiko; Streeck, Hendrik; Widera, Marek; Yang, Rongge; Dittmer, Ulf; Sutter, Kathrin
    Expression pattern of individual IFNA subtypes in chronic HIV infection
    In: Journal of Interferon & Cytokine Research Jg. 37 (2017) Nr. 12, S. 541 - 549
  • Malyshkina, Anna; Littwitz-Salomon, Elisabeth; Sutter, Kathrin; Zelinskyy, Gennadiy; Windmann, Sonja; Schimmer, Simone; Paschen, Annette; Streeck, Hendrik; Hasenkrug, Kim J; Dittmer, Ulf
    Fas Ligand-mediated cytotoxicity of CD4+ T cells during chronic retrovirus infection
    In: Scientific Reports Jg. 7 (2017) S. 7785
  • Ziegler, Susanne M.; Beisel, Claudia; Sutter, Kathrin; Griesbeck, Morgane; Hildebrandt, Heike; Hagen, Sven H.; Dittmer, Ulf; Altfeld, Marcus
    Human pDCs display sex-specific differences in type I interferon subtypes and interferon α/β receptor expression
    In: European Journal of Immunology Jg. 47 (2017) Nr. 2, S. 251 - 256
  • Schreiber, Timm; Quinting, Theresa; Dittmer, Ulf; Fandrey, Joachim; Sutter, Kathrin
    Hypoxia-inducible factor 1α is essential for macrophage-mediated erythroblast proliferation in acute friend retrovirus infection
    In: Scientific Reports Jg. 7 (2017) art. no. 17236
  • 2016

    Artikel in Zeitschriften

  • Blömker, Dominique; Mollérus, Sina; Gibbert, Kathrin; Dittmer, Ulf; Del Rey, Adriana E.; Schedlowski, Manfred; Engler, Harald
    Inhibition of catecholamine degradation ameliorates while chemical sympathectomy aggravates the severity of acute Friend retrovirus infection in mice
    In: Brain, Behavior and Immunity Jg. 54 (2016) S. 252 - 259
  • Littwitz-Salomon, Elisabeth; Dittmer, Ulf; Sutter, Kathrin
    Insufficient natural killer cell responses against retroviruses : How to improve NK cell killing of retrovirus-infected cells
    In: Retrovirology Jg. 13 (2016) Nr. 1, 77
  • Lavender, Kerry J.; Gibbert, Kathrin; Peterson, Karin E.; Van Dis, Erik; Francois, Sandra; Woods, Tyson; Messer, Ronald J.; Gawanbacht, Ali; Müller, Janis A.; Münch, Jan; Phillips, Katie; Race, Brent; Harper, Michael S.; Guo, Kejun; Lee, Eric J.; Trilling, Mirko; Hengel, Hartmut; Piehler, Jacob; Verheyen, Jens; Wilson, Cara C.; Santiago, Mario L.; Hasenkrug, Kim J.; Dittmer, Ulf
    Interferon alpha subtype-specific suppression of HIV-1 infection in vivo
    In: Journal of Virology Jg. 90 (2016) Nr. 13, S. 6001 - 6013
  • 2015

    Artikel in Zeitschriften

  • Littwitz-Salomon, Elisabeth; Akhmetzyanova, Ilseyar; Vallet, Cecilia; Francois, Sandra; Dittmer, Ulf; Gibbert, Kathrin
    Activated regulatory T cells suppress effector NK cell responses by an IL-2-mediated mechanism during an acute retroviral infection
    In: Retrovirology Jg. 12 (2015) Nr. 1, 66
  • Harper, Michael S.; Guo, Kejun; Gibbert, Kathrin; Lee, Eric J.; Dillon, Stephanie M.; Barrett, Bradley S.; McCarter, Martin D.; Hasenkrug, Kim J.; Dittmer, Ulf; Wilson, Cara C.; Santiago, Mario L.
    Interferon-α subtypes in an ex vivo model of acute HIV-1 infection : expression, potency and effector mechanisms
    In: PLoS Pathogens Jg. 11 (2015) Nr. 11, S. e1005254
  • Wu, Weimin; Dietze, Kirsten; Gibbert, Kathrin; Lang, Karl S.; Trilling, Mirko; Yan, Huimin; Wu, Jun; Yang, Dongliang; Lu, Mengji; Roggendorf, Michael; Dittmer, Ulf; Liu, Jia
    TLR ligand induced IL-6 counter-regulates the anti-viral CD8+ T cell response during an acute retrovirus infection
    In: Scientific Reports Jg. 5 (2015) 10501
  • 2014

    Artikel in Zeitschriften

  • Bröring, Ruth; Real, Catherine; John, Matthias J.; Jahn-Hofmann, Kerstin; Ickenstein, Ludger M.; Kleinehr, Kathrin; Paul, Andreas; Sutter, Kathrin; Dittmer, Ulf; Gerken, Guido; Schlaak, Jörg Friedrich
    Chemical modifications on siRNAs avoid Toll-like-receptor-mediated activation of the hepatic immune system in vivo and in vitro
    In: International Immunology Jg. 26 (2014) Nr. 1, S. 35 - 46
  • 2013

    Artikel in Zeitschriften

  • Littwitz-Salomon, Elisabeth; Francois, Sandra; Dittmer, Ulf; Gibbert, Kathrin
    Distinct roles of NK cells in viral immunity during different phases of acute Friend retrovirus infection
    In: Retrovirology Jg. 10 (2013) Nr. 1, 127
  • Gibbert, K.; Schlaak, Jörg Friedrich; Yang, D.; Dittmer, Ulf; Schlaak, JF
    IFN-α subtypes : Distinct biological activities in anti-viral therapy
    In: British Journal of Pharmacology (BJP) Jg. 168 (2013) Nr. 5, S. 1048 - 1058
  • Harper, Michael S.; Barrett, Bradley S.; Smith, Diana S.; Li, Sam X.; Gibbert, Kathrin; Dittmer, Ulf; Hasenkrug, Kim J.; Santiago, Mario L.
    IFN-α treatment inhibits acute friend retrovirus replication primarily through the antiviral effector molecule Apobec3
    In: The Journal of Immunology (JI) Jg. 190 (2013) Nr. 4, S. 1583 - 1590
  • Behrendt, Rayk; Schumann, Tina; Gerbaulet, Alexander; Nguyen, Laura A.; Schubert, Nadja; Alexopoulou, Dimitra; Berka, Ursula; Lienenklaus, Stefan; Peschke, Katrin; Gibbert, Kathrin; Wittmann, Sabine; Lindemann, Dirk; Weiss, Siegfried; Dahl, Andreas; Naumann, Ronald; Dittmer, Ulf; Kim, Baek; Mueller, Werner; Gramberg, Thomas; Roers, Axel
    Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response
    In: Cell Reports Jg. 4 (2013) Nr. 4, S. 689 - 696
  • Wobben, Regina; Hüsecken, Yvonne; Lodewick, Claudia; Gibbert, Kathrin; Fandrey, Joachim; Winning, Sandra
    Role of hypoxia inducible factor-1 α for interferon synthesis in mouse dendritic cells
    In: Biological Chemistry Jg. 394 (2013) Nr. 4, S. 495 - 505
  • 2012

    Artikel in Zeitschriften

  • Gibbert, Kathrin; Joedicke, Jara J.; Meryk, Andreas; Trilling, Mirko; Francois, Sandra; Duppach, Janine; Kraft, Anke; Lang, Karl S.; Dittmer, Ulf
    Interferon-alpha Subtype 11 Activates NK Cells and Enables Control of Retroviral Infection
    In: PLoS Pathogens Jg. 8 (2012) Nr. 8, S. e1002868
  • 2011

    Artikel in Zeitschriften

  • Gibbert, Kathrin; Dittmer, Ulf
    Distinct antiviral activities of IFN-α subtypes
    In: Immunotherapy Jg. 3 (2011) Nr. 7, S. 813 - 816
  • Dietze, Kirsten; Zelinskyy, Gennadiy; Gibbert, Kathrin; Schimmer, Simone; Francois, Sandra; Myers, Lara; Sparwasser, Tim; Hasenkrug, Kim J.; Dittmer, Ulf
    Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8⁺ T cells and reduces chronic retroviral set points
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Jg. 108 (2011) Nr. 6, S. 2420 - 2425
  • Zelinskyy, Gennadiy; Myers, Lara; Dietze, Kirsten; Gibbert, Kathrin; Roggendorf, Michael; Liu, Jia; Lu, Mengji; Kraft, Anke R.; Teichgräber, Volker; Hasenkrug, Kim J.; Dittmer, Ulf
    Virus-Specific CD8+ T Cells Upregulate Programmed Death-1 Expression during Acute Friend Retrovirus Infection but Are Highly Cytotoxic and Control Virus Replication
    In: The Journal of Immunology (JI) Jg. 187 (2011) Nr. 7, S. 3730 - 3737
  • 2010

    Artikel in Zeitschriften

  • Sender, Linda Y.; Gibbert, Kathrin; Suezer, Yasemin; Radeke, Heinfried H.; Kalinke, Ulrich; Waibler, Zoe
    CD40 ligand-triggered human dendritic cells mount interleukin-23 responses that are further enhanced by danger signals
    In: Molecular Immunology Jg. 47 (2010) Nr. 6, S. 1255 - 1261
  • Gibbert, Kathrin; Dietze, Kirsten; Zelinskyy, Gennadiy; Lang, Karl S.; Barchet, Winfried; Kirschning, Carsten Jürgen; Dittmer, Ulf
    Polyinosinic-polycytidylic acid treatment of Friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced disease
    In: The Journal of Immunology (JI) Jg. 185 (2010) Nr. 10, S. 6179 - 6189

Logo Sgvivi 192px Homepage Png

 Logo Grk1949 Freigestellt

 Logo Wzi Rgb Deutsch-01 _2_

 Signet Ude Rgb